lysyl hydroxylase

Summary

Gene Symbol: lysyl hydroxylase
Description: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Alias: EDS6, LH1, LLH, PLOD, lysine hydroxylase, lysyl hydroxlase 1, procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1, procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Species: human

Top Publications

  1. ncbi Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1
    K Passoja
    Biocenter and Department of Medical Biochemistry, University of Oulu, Finland
    FEBS Lett 434:145-8. 1998
  2. ncbi Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI
    H N Yeowell
    Division of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    Matrix Biol 19:37-46. 2000
  3. ncbi Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
    Kati Rautavuoma
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 277:23084-91. 2002
  4. ncbi A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito
    H V Toriello
    Cytogenetics Laboratory, Butterworth Hospital, Grand Rapids, Michigan 49503, USA
    Nat Genet 13:361-5. 1996
  5. ncbi Ehlers-Danlos syndrome type VIB with characteristic facies, decreased curvatures of the spinal column, and joint contractures in two unrelated girls
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 138:282-7. 2005
  6. ncbi Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts
    Mitsuru Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:1695-705. 2003
  7. ncbi An Ehlers-Danlos syndrome type VIA patient with cystic malformations of the meninges
    Heather N Yeowell
    Div of Dermatology, Duke Univ Medical Centre, Durham, NC, USA
    Eur J Dermatol 15:353-8. 2005
  8. ncbi Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    J Brinckmann
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Matrix Biol 24:459-68. 2005
  9. doi A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 152:1333-46. 2010
  10. ncbi Differential diagnosis of muscular hypotonia in infants: the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI)
    Uluc Yis
    Division of Child Neurology, Dokuz Eylul University School of Medicine, Department of Pediatrics, 35340 Izmir, Turkey
    Neuromuscul Disord 18:210-4. 2008

Research Grants

  1. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
  2. TWO CANDIDATE GENES LINKED TO LOW BONE DENSITY
    LORETTA SPOTILA; Fiscal Year: 2001
  3. Collagen remodeling and tumor progression
    Valerie Marie Weaver; Fiscal Year: 2010
  4. REGULATION OF COLLAGEN MATRIX MINERALIZATION
    Mitsuo Yamauchi; Fiscal Year: 2007
  5. Structural Studies of Photosynthetic Membrane Proteins
    MATTHEW CRADDOCK; Fiscal Year: 2007
  6. Phase 3A of a 3-phase 1.3-GHz LTS/HTS NMR magnet
    YUKIKAZU IWASA; Fiscal Year: 2009
  7. Phase 3A of a 3-phase 1.3-GHz LTS/HTS NMR magnet
    YUKIKAZU NA IWASA; Fiscal Year: 2010
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2001
  9. MEMBRANE PROTEINS--STRUCTURE, DYNAMICS AND STABILITY
    CRAIG SCHENCK; Fiscal Year: 2002
  10. CLIENTS WHO SEEK ON-LINE DRUG TREATMENT
    MAMIE WONG; Fiscal Year: 2003

Detail Information

Publications155 found, 100 shown here

  1. ncbi Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1
    K Passoja
    Biocenter and Department of Medical Biochemistry, University of Oulu, Finland
    FEBS Lett 434:145-8. 1998
    b>Lysyl hydroxylase catalyzes the formation of hydroxylysine in collagens by a reaction that involves oxidative decarboxylation of 2-oxoglutarate...
  2. ncbi Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI
    H N Yeowell
    Division of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    Matrix Biol 19:37-46. 2000
    This study describes the relative contribution of the 10 cysteine residues in lysyl hydroxylase 1 (LH1) to enzyme activity...
  3. ncbi Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
    Kati Rautavuoma
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 277:23084-91. 2002
    b>Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens; three human isoenzymes have been cloned so far...
  4. ncbi A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito
    H V Toriello
    Cytogenetics Laboratory, Butterworth Hospital, Grand Rapids, Michigan 49503, USA
    Nat Genet 13:361-5. 1996
    ..types I and III have been demonstrated in EDS types VII and IV, respectively, while mutations in the lysyl hydroxylase and ATP7A genes, with roles in collagen cross-linking, are responsible for EDS types VI and IX...
  5. ncbi Ehlers-Danlos syndrome type VIB with characteristic facies, decreased curvatures of the spinal column, and joint contractures in two unrelated girls
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 138:282-7. 2005
    ..b>Lysyl hydroxylase deficiency was ruled out in Patient 1. Parental consanguinity was present in Patient 2...
  6. ncbi Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts
    Mitsuru Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:1695-705. 2003
    ..We found that altered gravitational load affected the post-translational modification of collagen, particularly the collagen maturation pathway, through altered expression of enzymes involved in cross-link formation...
  7. ncbi An Ehlers-Danlos syndrome type VIA patient with cystic malformations of the meninges
    Heather N Yeowell
    Div of Dermatology, Duke Univ Medical Centre, Durham, NC, USA
    Eur J Dermatol 15:353-8. 2005
    ..9 kb in the lysyl hydroxylase 1 (LH1) gene that is the cause of severely decreased levels of LH activity in her skin fibroblasts...
  8. ncbi Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    J Brinckmann
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Matrix Biol 24:459-68. 2005
    ..In the present study, we analyzed the cross-link pattern and the gene expression of lysyl hydroxylase 2 (LH2) in the skin of SSc...
  9. doi A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 152:1333-46. 2010
    ..and skeletal features, overlapping with the kyphoscoliosis type Ehlers-Danlos syndrome (EDS) but without lysyl hydroxylase deficiency [Kosho et al. (2005) Am J Med Genet Part A 138A:282-287]...
  10. ncbi Differential diagnosis of muscular hypotonia in infants: the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI)
    Uluc Yis
    Division of Child Neurology, Dokuz Eylul University School of Medicine, Department of Pediatrics, 35340 Izmir, Turkey
    Neuromuscul Disord 18:210-4. 2008
    ..Biochemically, it is characterized by a deficiency of collagen lysyl hydroxylase (EC 1.14.11.4) due to mutations in PLOD1...
  11. ncbi Interstitial collagen synthesis and processing in human amnion: a property of the mesenchymal cells
    M L Casey
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas, Southwestern Medical Center, Dallas 75235, USA
    Biol Reprod 55:1253-60. 1996
    ..2(I), and alpha 1(III) subunit mRNAs and the specific activities of the enzymes prolyl 4-hydroxylase and lysyl hydroxylase were greatest in human amnion tissue early in gestation, decreasing rather abruptly after 12-14 wk gestation ..
  12. ncbi The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine
    David Eyre
    Orthopaedic Research Laboratories, University of Washington, Box 356500, Seattle, WA 98195 6500, USA
    Mol Genet Metab 76:211-6. 2002
    ..VIA) (OMIM 225400) is an autosomal recessive connective tissue disorder that results from mutations in the lysyl hydroxylase 1 gene (PLOD1) causing underhydroxylation of lysine residues in tissue collagens, particularly of skin...
  13. ncbi Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one family
    H N Yeowell
    Duke University Medical Center, Durham, NC 27710, USA
    Hum Mutat 16:90. 2000
    Screening of full length cDNAs for lysyl hydroxylase 1 (LH1; also PLOD) amplified from dermal fibroblasts from six unrelated patients with the autosomal recessive disorder Ehlers-Danlos syndrome type VI (EDS VI) has shown them to be both ..
  14. ncbi Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation
    L C Walker
    Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet A 131:155-62. 2004
    ..diagnosis of Ehlers-Danlos syndrome type VI (EDS VI; kyphoscoliosis type), have significantly decreased lysyl hydroxylase (LH) activity due to mutations in the LH1 gene (classified as EDS VIA: OMIM no. 225400)...
  15. pmc Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome--an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13
    Cecilia Giunta
    Division of Metabolism and Molecular Pediatrics, University Children s Hospital, CH 8032 Zurich, Switzerland
    Am J Hum Genet 82:1290-305. 2008
    ..2 in controls. Lysyl and prolyl residues of collagens were underhydroxylated despite normal lysyl hydroxylase and prolyl 4-hydroxylase activities; underhydroxylation was a generalized process as shown by mass ..
  16. ncbi Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences
    Kati Takaluoma
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014, Oulu, Finland
    Matrix Biol 26:396-403. 2007
    b>Lysyl hydroxylase (LH), with three isoenzymes in vertebrates, catalyzes the formation of hydroxylysine by acting on -X-Lys-Gly- triplets in the collagenous domains of proteins of the collagen superfamily and also in -X-Lys-Ala- or -X-Lys-..
  17. ncbi Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon
    A Samimi
    Pulmonary Critical Care Medicine, University of California, Davis, California 95616, USA
    Toxicol Appl Pharmacol 176:181-6. 2001
    Direct inhibition of lysyl hydroxylase by malathion and malaoxon was observed in an in vitro enzyme assay with recombinant lysyl hydroxylase expressed via a baculoviral system...
  18. ncbi Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase
    R Myllyla
    Collagen Research Unit, University of Oulu, Finland
    J Biol Chem 266:2805-10. 1991
    b>Lysyl hydroxylase (EC 1.14.11.4), an alpha 2 dimer, catalyzes the formation of hydroxylysine in collagens by the hydroxylation of lysine residues in X-Lys-Gly sequences...
  19. pmc Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice
    Kati Rautavuoma
    Collagen Research Unit and Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
    Proc Natl Acad Sci U S A 101:14120-5. 2004
    ..We generated mice with targeted inactivation of the gene for one of the three lysyl hydroxylase isoenzymes, LH3. The null embryos developed seemingly normally until embryonic day 8...
  20. ncbi Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling
    Antti M Salo
    Department of Biochemistry and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Cell Physiol 207:644-53. 2006
    b>Lysyl hydroxylase 3 (LH3), the multifunctional enzyme associated with collagen biosynthesis that possesses lysyl hydroxylase and collagen glycosyltransferase activities, has been characterized in the extracellular space in this study...
  21. ncbi Coenzyme A stimulates collagen production in cultured fibroblasts; possible mechanisms in enzymatic and gene expression
    K Mio
    Life Science Research Center, Lion Corporation, Odawara, Kanagawa, Japan
    Arch Dermatol Res 293:522-31. 2001
    ..hand, coenzyme A did not stimulate the activity nor the gene expression of two other processing enzymes: lysyl hydroxylase, which provides the sites for glycosylation and crosslinking between collagen peptides, and lysyl oxidase, a ..
  22. ncbi Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines
    Laura Sipilä
    Biocenter Oulu, Department of Biochemistry, University of Oulu, FI 90014 Oulu, Finland
    J Biol Chem 282:33381-8. 2007
    ..The formation of glycosylated hydroxylysines is catalyzed by multifunctional lysyl hydroxylase 3 (LH3) in vivo, and we have used LH3-manipulated mice and cells as models to study the function of these ..
  23. ncbi Procollagen synthesis is increased in hypothyroid rat ovary by a parallel and compensatory pathway
    Samir Kumar Saha
    Molecular Endocrinology Laboratory, Indian Institute of Chemical Biology, Kolkata, India
    Cell Physiol Biochem 19:313-22. 2007
    ..Down regulation of lysyl hydroxylase in hypothyroid condition results less collagen formation...
  24. ncbi Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes
    Janice A Vranka
    Research Department, Shriners Hospital for Children, Portland, Oregon 97239, USA
    J Biol Chem 279:23615-21. 2004
    ..3-hydroxylases, which share the conserved residues present in the active site of prolyl 4-hydroxylase and lysyl hydroxylase. P3H1 is the chick homologue of mammalian leprecan or growth suppressor 1...
  25. ncbi Morphological and molecular analysis of idiopathic gingival fibromatosis: a case report
    Nicoletta Gagliano
    Department of Human Morphology LITA Segrate, University of Milan, Milan, Italy
    J Clin Periodontol 32:1116-21. 2005
    ..As this overgrowth involves collagen accumulation in the gingival connective tissue, we measured the collagen turnover to clarify the pathogenic mechanisms potentially involved...
  26. ncbi The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration
    Valerie A Schneider
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Neuron 50:683-95. 2006
    ..cloning of diwanka and show that it encodes LH3, a myotomally expressed multifunctional enzyme with lysyl hydroxylase and glycosyltransferase domains...
  27. ncbi Vitamin C and bone markers: investigations in a Gambian population
    Karen Munday
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Proc Nutr Soc 62:429-36. 2003
    ..Vitamin C acts as a cofactor for the enzyme lysyl hydroxylase, which is required for the hydroxylation of lysine residues in procollagen chains...
  28. ncbi Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization
    Suchaya Pornprasertsuk
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7455, USA
    J Bone Miner Res 20:81-7. 2005
    ....
  29. pmc Cloning and characterization of a third human lysyl hydroxylase isoform
    K Passoja
    Collagen Research Unit, Biocenter and Department of Medical Biochemistry, University of Oulu, FIN 90220 Oulu, Finland
    Proc Natl Acad Sci U S A 95:10482-6. 1998
    b>Lysyl hydroxylase (EC 1.14.11.4), a homodimer, catalyzes the formation of hydroxylysine in collagens. Recently, an isoenzyme termed lysyl hydroxylase 2 has been cloned from human sources [M. Valtavaara, H. Papponen, A.-M. Pirttilä, K...
  30. ncbi Lack of collagen type specificity for lysyl hydroxylase isoforms
    C Wang
    Department of Biochemistry, University of Oulu, Finland
    DNA Cell Biol 19:71-7. 2000
    b>Lysyl hydroxylase is the enzyme catalyzing the formation of hydroxylysyl residues in collagens. Large differences in the extent of hydroxylysyl residues are found among collagen types...
  31. ncbi The let-268 locus of Caenorhabditis elegans encodes a procollagen lysyl hydroxylase that is essential for type IV collagen secretion
    K R Norman
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    Dev Biol 227:690-705. 2000
    ..We have identified several mutations in a procollagen processing enzyme, lysyl hydroxylase (let-268)...
  32. doi The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
    Chunguang Wang
    Department of Biochemistry, Biocenter Oulu, University of Oulu, Oulu, Finland
    J Cell Mol Med 13:508-21. 2009
    b>Lysyl hydroxylase (LH) isoform 3 is a post-translational enzyme possessing LH, collagen galactosyltransferase (GT) and glucosyltransferase (GGT) activities...
  33. ncbi Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ
    I Ishida
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Japan
    Graefes Arch Clin Exp Ophthalmol 239:770-7. 2001
    ..Minoxidil is an inhibitor of lysyl hydroxylase, an enzyme involved in procollagen hydroxylation...
  34. doi A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts
    N Gagliano
    Department of Human Morphology, Extracellular Matrix Laboratory EML, University of Milan, Milan, Italy
    Transplant Proc 40:1419-24. 2008
    ..Collagen type I and III (COL-I, COL-III), lysyl hydroxylase 2b (LH2b), MMP-1 and -2, tissue inhibitor of MMP-1 and transforming growth factor-beta1 (TGF-beta1) mRNA ..
  35. ncbi Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells
    Suchaya Pornprasertsuk
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7455, USA
    J Bone Miner Res 19:1349-55. 2004
    ..The data indicate that LH2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues...
  36. ncbi Development of a convenient peptide-based assay for lysyl hydroxylase
    Mare Cudic
    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431 0991, USA
    Biopolymers 90:330-8. 2008
    ..b>Lysyl hydroxylase (LH) catalyzes the hydroxylation of the C-5 position of a Lys residue, resulting in the production of Hyl...
  37. ncbi Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts
    Linda C Walker
    Division of Dermatology, Duke University Medical Center, Durham, Box 3135, NC 27710, USA
    Matrix Biol 23:515-23. 2005
    ..b>Lysyl hydroxylase 2 (LH2) exists as two alternatively-spliced forms; the long transcript (the major ubiquitously-expressed ..
  38. ncbi Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes
    Heli Ruotsalainen
    Department of Biochemistry, Biocenter Oulu, University of Oulu, FI 90014 Oulu, Finland
    J Cell Sci 119:625-35. 2006
    b>Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase (LH), hydroxylysyl galactosyltransferase (GT) and galactosylhydroxylysyl glucosyltransferase (GGT) activities in vitro...
  39. ncbi Tissue specificity of a new splice form of the human lysyl hydroxylase 2 gene
    H N Yeowell
    Division of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    Matrix Biol 18:179-87. 1999
    In this study we present the first report of alternative RNA splicing in a gene for lysyl hydroxylase (LH) in a normal population. This splicing event, which we have observed in the LH2 gene, appears to be tissue specific...
  40. pmc Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2
    Marjo Hyry
    Oulu Center for Cell Matrix Research, Biocenter Oulu, and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 284:30917-24. 2009
    ..Three point mutations in lysyl hydroxylase (LH) 2, the enzyme responsible for the hydroxylation of collagen telopeptides, have been identified in Bruck ..
  41. ncbi Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2
    Russia Ha-Vinh
    Division of Molecular Pediatrics, University of Lausanne, Lausanne, Switzerland
    Am J Med Genet A 131:115-20. 2004
    ..One BS locus has been mapped at 17p12, but more recently, two mutations in the lysyl hydroxylase 2 gene (PLOD2, 3q23-q24) have been identified in BS, showing genetic heterogeneity...
  42. pmc Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
    Maija Risteli
    Department of Biochemistry, P O Box 3000, University of Oulu, FI 90014 Oulu, Finland
    J Biol Chem 284:28204-11. 2009
    b>Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase, collagen galactosyltransferase, and glucosyltransferase (GGT) activities...
  43. ncbi Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3)
    K Rautavuoma
    Collagen Research Unit, Biocenter and Department of Medical Biochemistry, University of Oulu, Kajaanintie 52 A, FIN 90220, Oulu, Finland
    Matrix Biol 19:73-9. 2000
    b>Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens and related proteins by the hydroxylation of lysine residues in peptide linkages. Three isoenzymes of LH have so far been characterized...
  44. ncbi Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice
    K Reiser
    Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
    Am J Physiol 271:R696-703. 1996
    ..Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed...
  45. ncbi Evidence that impaired intracellular collagen synthesis reduces proliferation in cultured rat hepatocytes
    H Ikeda
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 200:1701-7. 1994
    ..The addition of P-1894B or minoxidil, which inhibits specifically prolyl hydroxylase or lysyl hydroxylase, respectively, also produced similar results...
  46. doi Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria
    Bone 46:703-9. 2010
    ..increased the ratio of pyr/divalent cross-links of collagen, and down-regulated mRNA expression of lysyl hydroxylase (Plod2) and lysyl oxidase (Lox), genes which play an important role in the formation of a stable matrix...
  47. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003
    ..5. We further demonstrate that the procollagen lysyl hydroxylase (PLOD1) promoter is regulated by Nkx2.5. Mechanistically, PITX2C and Nkx2...
  48. ncbi Penicillin G does not alter collagen type I metabolism of dermal fibroblasts in culture
    U Anderegg
    Department of Dermatology, Leipzig University, and Saxon Academy of Science, Leipzig, Germany
    Dermatology 200:111-4. 2000
    ..Penicillin G (PenG) has successfully been used for therapy of dermal fibrosis in patients suffering from systemic sclerosis (SSc). However, there is little knowledge on the mechanism of the antifibrotic action of PenG...
  49. ncbi cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase
    S Jia
    Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    J Biol Chem 267:14322-7. 1992
    ..amino acid sequences of two other alpha-ketoglutarate-dependent dioxygenases, prolyl-4-hydroxylase and lysyl hydroxylase, with that of Asp beta-hydroxylase showed no significant homologies...
  50. ncbi Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
    Monica Mantri
    Department of Chemistry and Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
    J Mol Biol 401:211-22. 2010
    ..Together with mutational studies, the structural data suggest how JMJD6 binds its lysyl residues such that it can catalyse C-5 hydroxylation rather than Nepsilon-demethylation, as for analogous enzymes...
  51. pmc Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2
    Valerie A Schneider
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia, PA 19104 6058, USA
    Matrix Biol 26:12-9. 2007
    Collagen biosynthesis in both invertebrates and vertebrates is critically dependent upon the activity of lysyl hydroxylase (LH) enzymes...
  52. ncbi Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle
    M Valtavaara
    Biocenter and Department of Biochemistry, University of Oulu, FIN 90570 Oulu, Finland
    J Biol Chem 272:6831-4. 1997
    We report the isolation and characterization of cDNA clones for a novel isoform of lysyl hydroxylase (lysyl hydroxylase 2), a posttranslational enzyme of collagen biosynthesis...
  53. pmc The PuhB protein of Rhodobacter capsulatus functions in photosynthetic reaction center assembly with a secondary effect on light-harvesting complex 1
    Muktak Aklujkar
    Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Blvd, Vancouver, British Columbia V6T 1Z3, Canada
    J Bacteriol 187:1334-43. 2005
    ..as Rhodobacter capsulatus consists of a reaction center (RC) intimately associated with light-harvesting complex 1 (LH1) and the PufX polypeptide...
  54. doi Variation in supramolecular organisation of the photosynthetic membrane of Rhodobacter sphaeroides induced by alteration of PufX
    Kinga Sznee
    Division of Physics and Astronomy, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands
    Photosynth Res 119:243-56. 2014
    In purple bacteria of the genus Rhodobacter (Rba.), an LH1 antenna complex surrounds the photochemical reaction centre (RC) with a PufX protein preventing the LH1 complex from completely encircling the RC. In membranes of Rba...
  55. ncbi Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis
    Anne Marie Zuurmond
    TNO Quality of Life, Biomedical Research, Department of Tissue Repair, P O Box 2215, 2301 CE Leiden, The Netherlands
    Matrix Biol 24:261-70. 2005
    ..Based on its inhibitory effect on lysyl hydroxylase activity minoxidil has been postulated to possess anti-fibrotic properties by limiting the hydroxylysine ..
  56. pmc Phenotypic variability of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA): clinical, molecular and biochemical delineation
    Marianne Rohrbach
    Division of Metabolism, University Children s Hospital and Children s Research Centre, Zurich, Switzerland
    Orphanet J Rare Dis 6:46. 2011
    ..OMIM 225400) is a rare inheritable connective tissue disorder characterized by a deficiency of collagen lysyl hydroxylase 1 (LH1; EC 1.14.11.4) due to mutations in PLOD1...
  57. doi Excitation energy trapping and dissipation by Ni-substituted bacteriochlorophyll a in reconstituted LH1 complexes from Rhodospirillum rubrum
    Petar H Lambrev
    Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt 62, 6726 Szeged, Hungary
    J Phys Chem B 117:11260-71. 2013
    ..the central Mg(2+) ion was used as an ultrafast excitation energy dissipation center in reconstituted bacterial LH1 complexes...
  58. doi Carotenoid charge transfer states and their role in energy transfer processes in LH1-RC complexes from aerobic anoxygenic phototrophs
    Václav Slouf
    Faculty of Science, University of South Bohemia, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    J Phys Chem B 117:10987-99. 2013
    ..In the present work, transient absorption measurements were performed on LH1-RC complexes isolated from two aerobic anoxygenic phototrophs (AAPs), Roseobacter sp...
  59. doi Does the Reconstitution of RC-LH1 Complexes from Rhodopseudomonas acidophila Strain 10050 into a Phospholipid Bilayer Yield the Optimum Environment for Optical Spectroscopy?
    Paul S Böhm
    Experimental Physics IV and Bayreuth Institute for Macromolecular Research BIMF, University of Bayreuth, 95440 Bayreuth, Germany
    J Phys Chem B 117:15004-13. 2013
    We have investigated reaction-center light-harvesting 1 (RC-LH1) complexes from Rhodopseudomonas (Rps...
  60. ncbi Characterization of collagenous peptides bound to lysyl hydroxylase isoforms
    Maija Risteli
    Department of Biochemistry, Biocenter Oulu, University of Oulu, P O Box 3000, FIN 90014, University of Oulu, Finland
    J Biol Chem 279:37535-43. 2004
    b>Lysyl hydroxylase (LH, EC 1.14.11.4) is the enzyme catalyzing the formation of hydroxylysyl residues in collagens and other proteins with collagenous domains...
  61. doi Structure, function and interactions of the PufX protein
    Kate Holden-Dye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
    Biochim Biophys Acta 1777:613-30. 2008
    The PufX protein is an important component of the reaction centre-light-harvesting 1 (RC-LH1) complex of Rhodobacter species of purple photosynthetic bacteria...
  62. doi Influence of hydrophobic micelle structure on crystallization of the photosynthetic RC-LH1-PufX complex from Rhodobacter blasticus
    Laurie Anne Barret
    Institut des Biomolécules Max Mousseron IBMM UMR 5247 CNRS Universités Montpellier 1 et 2, Chimie Bioorganique et Systèmes Amphiphiles, Universite d Avignon et des Pays de Vaucluse, 33 rue Louis Pasteur, F 84000 Avignon, France
    J Phys Chem B 117:8770-81. 2013
    ..percentages of polyethylene glycol 3350, in order to correlate surfactant intermicellar interactions and RC-LH1-PufX phase diagram...
  63. ncbi Functional consequences of the organization of the photosynthetic apparatus in Rhodobacter sphaeroides. I. Quinone domains and excitation transfer in chromatophores and reaction center.antenna complexes
    Frédéric Comayras
    Unité Mixte de Recherche 6191 CNRS Commissariat à l Energie Atomique Aix Marseille II, Département d Ecophysiologie Végétale et de Microbiologie, Commissariat à l Energie Atomique Cadarache, 13108 Saint Paul lez Durance Cedex, France
    J Biol Chem 280:11203-13. 2005
    ..Isolated complexes of the reaction center (RC) with its core antenna ring (light-harvesting complex 1 (LH1)) were studied in their dimeric (native) form or as monomers with respect to excitation transfer and distribution ..
  64. pmc Structure of the dimeric RC-LH1-PufX complex from Rhodobaca bogoriensis investigated by electron microscopy
    Dmitry A Semchonok
    Electron Microscopy Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, Groningen, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 367:3412-9. 2012
    ..microscopy and single-particle averaging were performed on isolated reaction centre (RC)-antenna complexes (RC-LH1-PufX complexes) of Rhodobaca bogoriensis strain LBB1, with the aim of establishing the LH1 antenna conformation, ..
  65. pmc The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin
    Heli Ruotsalainen
    Department of Biochemistry, University of Oulu, Oulu, Finland
    PLoS ONE 7:e50045. 2012
    b>Lysyl hydroxylase 3 (LH3) has lysyl hydroxylase, galactosyltransferase, and glucosyltransferase activities, which are sequentially required for the formation of glucosylgalactosyl hydroxylysines in collagens...
  66. doi Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease
    Mei Sian Chong
    Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore
    J Alzheimers Dis 34:399-405. 2013
    ....
  67. doi Increasing the open-circuit voltage of photoprotein-based photoelectrochemical cells by manipulation of the vacuum potential of the electrolytes
    Swee Ching Tan
    Nanoscience Centre, University of Cambridge, 11 JJ Thomson Avenue, Cambridge CB3 0FF, UK
    ACS Nano 6:9103-9. 2012
    ..work explored the basis of the open-circuit voltage (V(OC)) produced by such cells with reaction center/antenna (RC-LH1) proteins as the photovoltaic component...
  68. doi Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome
    Noriko Miyake
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Mutat 31:966-74. 2010
    ..A new type of EDS, similar to kyphoscoliosis type but without lysyl hydroxylase deficiency, has been investigated...
  69. doi Metal cations modulate the bacteriochlorophyll-protein interaction in the light-harvesting 1 core complex from Thermochromatium tepidum
    Yukihiro Kimura
    Organization of Advanced Science and Technology, Kobe University, Nada, Kobe, Japan
    Biochim Biophys Acta 1817:1022-9. 2012
    The light-harvesting 1 reaction center (LH1-RC) complex from Thermochromatium (Tch...
  70. doi Coupling of different isolated photosynthetic light harvesting complexes and CdSe/ZnS nanocrystals via Förster resonance energy transfer
    F J Schmitt
    Institute of Chemistry, Biophysical Chemistry, Berlin Institute of Technology, Berlin, Germany
    Biochim Biophys Acta 1817:1461-70. 2012
    ..complexes from the light-harvesting antennae of photosynthetic organisms (light-harvesting complexes 1 and 2 (LH1 and LH2, respectively) from purple bacteria, phycobiliproteins (PBPs) from cyanobacteria and the rod-shaped PBP ..
  71. ncbi Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders
    H N Yeowell
    Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710
    Arch Biochem Biophys 308:299-305. 1994
    ..increases the mRNAs for both the alpha and the beta subunits of prolyl hydroxylase (PH) and the mRNAs for lysyl hydroxylase, also increased LO mRNA by fourfold over a 72-h time course...
  72. ncbi The solution structure of the PufX polypeptide from Rhodobacter sphaeroides
    Richard B Tunnicliffe
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    FEBS Lett 580:6967-71. 2006
    PufX organizes the photosynthetic reaction centre-light harvesting complex 1 (RC-LH1) core complex of Rhodobacter sphaeroides and facilitates quinol/quinone exchange between the RC and cytochrome bc(1) complexes...
  73. doi Carotenoids are essential for normal levels of dimerisation of the RC-LH1-PufX core complex of Rhodobacter sphaeroides: characterisation of R-26 as a crtB (phytoene synthase) mutant
    Irene W Ng
    Department of Molecular Biology and Biochemistry, University of Sheffield S10 2TN, UK
    Biochim Biophys Acta 1807:1056-63. 2011
    ..to examine the effects of carotenoids on the oligomeric state of the reaction centre-light-harvesting 1 -PufX (RC-LH1-PufX) core complex of Rhodobacter sphaeroides two carotenoid-less mutants, TC70 and R-26, were studied...
  74. doi Hypoglicemic effect of Leandra lacunosa in normal and alloxan-induced diabetic rats
    W R Cunha
    Núcleo de Pesquisas em Ciências Exatas e Tecnológicas da Universidade de Franca, Franca, Avenida Dr Armando Salles de Oliveira, 201 14404 600 Franca SP, Brazil
    Fitoterapia 79:356-60. 2008
    ..lacunosa aerial parts (LLH) in normal and alloxan-induced diabetic rats...
  75. doi Light-harvesting antenna system from the phototrophic bacterium Roseiflexus castenholzii
    Aaron M Collins
    Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
    Biochemistry 49:7524-31. 2010
    ..that 3C-acetyl groups of BChl a are all involved in molecular interactions probably similar to those found in LH1 complexes from purple photosynthetic bacteria...
  76. doi Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts
    Wupeng Liao
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Proteomics 8:2640-50. 2008
    ..levels of myxovirus resistance protein A, interferon-stimulated gene 15, plasminogen activator inhibitor-2, lysyl hydroxylase 2 (isoform a), and prolyl 4-hydroxylase (alpha subunit) in human lung fibroblasts...
  77. doi Immobilization of porphyrin derivatives with a defined distance and orientation onto a gold electrode using synthetic light-harvesting α-helix hydrophobic polypeptides
    Tsuyoshi Ochiai
    Graduate School of Engineering, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
    Langmuir 26:14419-22. 2010
    ..This method is clearly successful in allowing assembly of porphyrins together with LH1 type functional complexes with a defined distance and orientation on the electrode...
  78. doi Three-dimensional reconstruction of a membrane-bending complex: the RC-LH1-PufX core dimer of Rhodobacter sphaeroides
    Pu Qian
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Biol Chem 283:14002-11. 2008
    A three-dimensional model of the dimeric reaction center-light harvesting I-PufX (RC-LH1-PufX) complex from Rhodobacter sphaeroides, calculated from electron microscope single particle analysis of negatively stained complexes, shows that ..
  79. pmc Direct visualization of exciton reequilibration in the LH1 and LH2 complexes of Rhodobacter sphaeroides by multipulse spectroscopy
    Thomas A Cohen Stuart
    Faculty of Sciences, Free University of Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Biophys J 100:2226-33. 2011
    The dynamics of the excited states of the light-harvesting complexes LH1 and LH2 of Rhodobacter sphaeroides are governed, mainly, by the excitonic nature of these ring-systems...
  80. pmc Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod
    Stephanie Bunt
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
    Gene Expr Patterns 11:72-8. 2011
    The lysyl hydroxylase (LH) family of enzymes has important roles in the biosynthesis of collagen. In this paper we present the first description of Drosophila LH3 (dPlod), the only lysyl hydroxylase encoded in the fly genome...
  81. ncbi Substrate specificity of platypus venom L-to-D-peptide isomerase
    Paramjit S Bansal
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 283:8969-75. 2008
    ..None of the hexapeptides based on LLH, the first three residues of OvCNP, were substrates...
  82. doi Lysyl hydroxylase 3 is secreted from cells by two pathways
    Chunguang Wang
    Department of Biochemistry, Faculty of Science, University of Oulu, Oulu, Finland
    J Cell Physiol 227:668-75. 2012
    b>Lysyl hydroxylase 3 (LH3) is a post-translational modification enzyme with lysyl hydroxylase (LH), collagen galactosyltransferase (GT), and glucosyltransferase (GGT) activities...
  83. doi Actinotrichia collagens and their role in fin formation
    I Duran
    Department of Cell Biology, Genetics and Physiology, Faculty of Science, University of Malaga, Malaga, Spain
    Dev Biol 354:160-72. 2011
    ..Both col1a1a and col2a1b were found in actinotrichia forming cells. Significantly, they also expressed the lysyl hydroxylase 1 (lh1) gene, which encodes an enzyme involved in the post-translational processing of collagens...
  84. doi Dark excited States of carotenoid regulated by bacteriochlorophyll in photosynthetic light harvesting
    Ryosuke Nakamura
    Department of Physics, Graduate School of Science, Tohoku University, Aoba ku, Sendai, Japan
    J Phys Chem B 115:3233-9. 2011
    ..We performed femtosecond TA spectroscopy combined with pre-excitation of BChl in the reconstituted LH1 complex from Rhodospirillum rubrum S1...
  85. doi Collagen cross-linking by adipose-derived mesenchymal stromal cells and scar-derived mesenchymal cells: Are mesenchymal stromal cells involved in scar formation?
    Antoon J van den Bogaerdt
    Association of Dutch Burn Centres, Beverwijk, The Netherlands
    Wound Repair Regen 17:548-58. 2009
    ..The enzyme lysyl hydroxylase-2b (LH-2b) plays a crucial role in this type of cross-linking...
  86. pmc Fox-2 protein regulates the alternative splicing of scleroderma-associated lysyl hydroxylase 2 messenger RNA
    Puneet Seth
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 62:1167-75. 2010
    ..b>Lysyl hydroxylase 2 (LH2), an important alternatively spliced enzyme in collagen biosynthesis, acts as a collagen telopeptide ..
  87. doi Energy migration as related to the mutual position and orientation of donor and acceptor molecules in LH1 and LH2 antenna complexes of purple bacteria
    A Y Borisov
    A N Belozersky Institute of Physico Chemical Biology, M V Lomonosov Moscow State University, Vorob ev Hills, Moscow, 119992, Russia
    Photosynth Res 97:215-22. 2008
    ..The corrected magnitudes of interaction energies of neighboring bacteriochlorophyll molecules in LH2 and LH1 light-absorbing complexes are calculated for the class of photosynthetic purple bacteria...
  88. doi Light harvesting, energy transfer and electron cycling of a native photosynthetic membrane adsorbed onto a gold surface
    Gerhard J Magis
    Biophysics, Leiden University, P O Box 9502, 2300RA Leiden, The Netherlands
    Biochim Biophys Acta 1798:637-45. 2010
    ..The component at the interface of light harvesting and electron cycling, the LH1 complex, displays exceptional stability, likely contributing to the robustness of the membranes...
  89. doi Exploring electron spin-spin interactions of paramagnetic iron and radical cations of bacteriochlorophyll from oxidized LH1 in the presence of electron transfer in the frozen state
    Petersen L Hasjim
    Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA
    J Phys Chem B 114:14194-9. 2010
    Cation free radicals of bacteriochlorophyll (BChl(+)) are formed in the light harvesting complex 1 (LH1) of photosynthetic bacteria upon oxidation by potassium ferricyanide...
  90. doi Digenic inheritance of mutations in FOXC1 and PITX2 : correlating transcription factor function and Axenfeld-Rieger disease severity
    Daniel Kelberman
    Ulverscroft Vision Research Group, UCL Institute of Child Health, London, United Kingdom
    Hum Mutat 32:1144-52. 2011
    ..This suggests an under-reported mechanism for phenotypic variability whereby single mutations cause mild AR phenotypes, whereas digenic inheritance increases phenotypic severity...
  91. doi ENDOR study of charge migration in photosynthetic arrays of Rhodobacter sphaeroides
    Petersen L Hasjim
    Department of Chemistry, University of Chicago, Chicago, IL 60637, USA
    Chemphyschem 11:1258-64. 2010
    ..in the dark, cation radicals of bacteriochlorophyll (BChl) can be formed in the light harvesting complex 1 (LH1) of Rhodobacter sphaeroides...
  92. pmc Enhanced transforming growth factor-beta signaling and fibrogenesis in ovine fetal skeletal muscle of obese dams at late gestation
    Yan Huang
    Center for the Study of Fetal Programming, Department of Animal Science, University ofWyoming, Laramie, WY 82071, USA
    Am J Physiol Endocrinol Metab 298:E1254-60. 2010
    ..In addition, enzymes involved in collagen synthesis, including lysyl oxidase, lysyl hydroxylase 2b, and prolyl 4-hydroxylase-alpha1, were increased by 350.2 +/- 90.0 (P < 0.05), 236.5 +/- 25...
  93. doi Selective chemical shift assignment of bacteriochlorophyll a in uniformly [13C-15N]-labeled light-harvesting 1 complexes by solid-state NMR in ultrahigh magnetic field
    Anjali Pandit
    Leiden Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Phys Chem B 114:6207-15. 2010
    ..the electronic ground state characteristics of the bacteriochlorophyll a (BChl a) cofactors in light-harvesting 1 (LH1) complexes of Rhodopseudomonas acidophila (strain 10050)...
  94. pmc Mechanistic and structural studies of the N-hydroxylating flavoprotein monooxygenases
    Jose Olucha
    Molecular Biosciences, University of Kansas, Lawrence, KS, United States
    Bioorg Chem 39:171-7. 2011
    ..the ornithine hydroxylases from Pseudomonas aeruginosa (PvdA) and Aspergillus fumigatus (SidA) and the lysine hydroxylase from Escherichia coli (IucD)...
  95. pmc The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis
    Annie Simard
    The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
    Dev Dyn 238:2459-70. 2009
    ..5 to transactivate the procollagen lysyl hydroxylase (Plod-1) promoter in transient transfection assays...
  96. doi Quinone pathways in entire photosynthetic chromatophores of Rhodospirillum photometricum
    Lu Ning Liu
    Institut Curie, Equipe INSERM AVENIR, UMR168 CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Mol Biol 393:27-35. 2009
    In photosynthetic organisms, membrane pigment-protein complexes [light-harvesting complex 1 (LH1) and light-harvesting complex 2 (LH2)] harvest solar energy and convert sunlight into an electrical and redox potential gradient (reaction ..
  97. pmc SANS investigation of the photosynthetic machinery of Chloroflexus aurantiacus
    Kuo Hsiang Tang
    Department of Biology, Washington University in St Louis, Missouri, USA
    Biophys J 99:2398-407. 2010
    ..aurantiacus is roughly comparable to the LH1 antenna complex of the purple bacteria...
  98. ncbi First-principle calculations on CO oxidation catalyzed by a gold nanoparticle
    Hsin Tsung Chen
    National Center for High Performance Computing, No 28, Nan Ke 3rd Road, Hsin Shi, Tainan 74147, Taiwan
    J Comput Chem 31:258-65. 2010
    ..72 eV; the potential energies of the two transition states (TS(LH1) and TS(LH2)) are smaller than the reactants, indicating that no net activation energy is required for this process...
  99. doi Atomic force microscopy studies of native photosynthetic membranes
    James N Sturgis
    Laboratoire d Ingenierie des Systemes Macromoleculaires, UPR 9027, Aix Marseille Universite, 31 Chemin Joseph Aiguier, 13402 Marseilles, France
    Biochemistry 48:3679-98. 2009
    ..ICM of Blastochloris viridis, consiting of hexagonally packed monomeric reaction center light-harvesting 1 (RC-LH1) core complexes...
  100. doi The effects of protein crowding in bacterial photosynthetic membranes on the flow of quinone redox species between the photochemical reaction center and the ubiquinol-cytochrome c2 oxidoreductase
    Kamil Woronowicz
    Department of Molecular Biology and Biochemistry, Rutgers University, Busch Campus, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Metallomics 3:765-74. 2011
    ..This supports the proposal that in this type of ICM, a network of RC-LH1 core complexes observed in AFM provides a pathway for long-range quinone diffusion that is unaffected by ..
  101. doi Specific Ca2+-binding motif in the LH1 complex from photosynthetic bacterium Thermochromatium tepidum as revealed by optical spectroscopy and structural modeling
    Fei Ma
    Department of Chemistry, Renmin University of China, Beijing, China
    FEBS J 276:1739-49. 2009
    Native and Ca(2+)-depleted light-harvesting-reaction center core complexes (LH1-RC) from the photosynthetic bacterium Thermochromatium (Tch.) tepidum exhibit maximal LH1-Q(y) absorption at 915 and 889 nm, respectively...

Research Grants68

  1. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..for the cross-linking process and the level of hydroxylation varies among tissues, Lysyl oxidase and lysyl hydroxylase are two enzymes involved in the early steps of the cross-linking process...
  2. TWO CANDIDATE GENES LINKED TO LOW BONE DENSITY
    LORETTA SPOTILA; Fiscal Year: 2001
    ..Two candidate genes located within this interval are PLOD, the gene for lysyl hydroxylase, and TNFR2, the gene for tumor necrosis factor-alpha receptor 2...
  3. Collagen remodeling and tumor progression
    Valerie Marie Weaver; Fiscal Year: 2010
    ..The lysyl oxidase and lysyl hydroxylase family of enzymes are also expressed in the stroma where they cross-link collagen fibrils to enhance the ..
  4. REGULATION OF COLLAGEN MATRIX MINERALIZATION
    Mitsuo Yamauchi; Fiscal Year: 2007
    ..To establish osteoblastic cell clones that synthesize low levels of lysyl hydroxylase-2 to switch the cross-linking pathway from mineralized to non-mineralized tissue phenotype, 1b...
  5. Structural Studies of Photosynthetic Membrane Proteins
    MATTHEW CRADDOCK; Fiscal Year: 2007
    ..understanding of this efficiency is a detailed structural knowledge of the major components of the antenna system, LH1, LH2, and the Reaction Center (RC), which are all membrane proteins...
  6. Phase 3A of a 3-phase 1.3-GHz LTS/HTS NMR magnet
    YUKIKAZU IWASA; Fiscal Year: 2009
    ..3 GHz LTS/HTS NMR magnet (LH1.3G)...
  7. Phase 3A of a 3-phase 1.3-GHz LTS/HTS NMR magnet
    YUKIKAZU NA IWASA; Fiscal Year: 2010
    ..3 GHz LTS/HTS NMR magnet (LH1.3G)...
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2001
    ..The SRO for the deletion has been narrowed to between markers PLOD and D1S80, which is estimated to correspond to less than 5 Mb, and a translocation with a breakpoint mapping within ..
  9. MEMBRANE PROTEINS--STRUCTURE, DYNAMICS AND STABILITY
    CRAIG SCHENCK; Fiscal Year: 2002
    ..b>LH1 protein, a 200 kD hetero-oligomeric membrane protein from photoheterotrophic eubacteria, undergoes multiple ..
  10. CLIENTS WHO SEEK ON-LINE DRUG TREATMENT
    MAMIE WONG; Fiscal Year: 2003
    ..Without this "cultural competence," investigators may plod forth with increasingly complex studies that yield equally complex findings, with unknown generalizability to ..
  11. CHARACTERIZATION OF LYSYL HYDROXYLASE ISOFORMS IN SKIN
    Heather Yeowell; Fiscal Year: 2007
    ..The identity of the telopeptide lysyl hydroxylase therefore becomes important to establish...
  12. CHARACTERIZATION OF LYSYL HYDROXYLASE ISOFORMS IN SKIN
    Heather Yeowell; Fiscal Year: 2004
    ..as deficient in LH; this enzyme deficiency results from different mutations in the originally identified LH gene (LH1)...
  13. COLLAGEN CROSS-LINKING IN SKELETAL AGING AND DISEASE
    David Eyre; Fiscal Year: 2009
    ..abstract_text> ..