Gene Symbol: Lyn
Description: LYN proto-oncogene, Src family tyrosine kinase
Alias: JTK8, p53Lyn, p56Lyn, tyrosine-protein kinase Lyn, lck/Yes-related novel protein tyrosine kinase, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Species: human
Products:     Lyn

Top Publications

  1. Lannutti B, Drachman J. Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood. 2004;103:3736-43 pubmed
    ..Similarly, proliferation is increased after introducing a dominant-negative form of Lyn into BaF3/Mpl cells...
  2. Lannutti B, Shim M, Blake N, Reems J, Drachman J. Identification and activation of Src family kinases in primary megakaryocytes. Exp Hematol. 2003;31:1268-74 pubmed
    ..Array profiles demonstrate that Fyn, Lyn, Fgr, Hck, Src, and Yes are all expressed in cultured human MKs (Fyn, Lyn>Src, Yes, Fgr, Hck)...
  3. Ikeda K, Nakayama Y, Togashi Y, Obata Y, Kuga T, Kasahara K, et al. Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. Exp Cell Res. 2008;314:3392-404 pubmed publisher
    ..b>Lyn, a member of the Src-family kinases, is known to play a role in DNA damage response and cell cycle control in the ..
  4. Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri Y, Fujimoto J. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. J Immunol. 2001;166:5567-77 pubmed
    ..of biochemically separated glycolipid-enriched membrane (GEM) fractions indicated enhanced association of CD24 and Lyn protein tyrosine kinase in GEM as well as increased Lyn kinase activity after CD24 cross-linking, suggesting that ..
  5. Choi H, Smithgall T. Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase. J Mol Biol. 2004;343:1255-68 pubmed
    ..Targeting the Nef hydrophobic pocket with a small molecule may be sufficient to disrupt Nef signaling through Hck in HIV-infected macrophages, slowing disease progression. ..
  6. Choi Y, Bocanegra M, Kwon M, Shin Y, Nam S, Yang J, et al. LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer. Cancer Res. 2010;70:2296-306 pubmed publisher
    ..The immunostaining of LYN, a top-ranked EMT signature gene and Src-family tyrosine kinase, was associated with significantly shorter overall ..
  7. Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood. 1998;91:3734-45 pubmed
    ..In the present study, we demonstrate that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/..
  8. Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, et al. Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J Cell Sci. 2009;122:965-75 pubmed publisher
    ..Recently, we showed that Lyn, an SFK member, is exocytosed to the plasma membrane via the Golgi region along the secretory pathway...
  9. Brunati A, Donella Deana A, James P, Quadroni M, Contri A, Marin O, et al. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. J Biol Chem. 1999;274:7557-64 pubmed
    ..We have now identified tyrosine 222 as the HS1 residue phosphorylated by the Src family protein kinases c-Fgr and Lyn, and we show that a truncated form of HS1 (HS1-208-401) lacking the N-terminal putative DNA binding region and the ..

More Information


  1. Yamanashi Y, Fukuda T, Nishizumi H, Inazu T, Higashi K, Kitamura D, et al. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J Exp Med. 1997;185:1387-92 pubmed
    ..Here, we show that BCR-associated tyrosine kinases Lyn and Syk synergistically phosphorylate HS1, and that Tyr-378 and Tyr-397 of HS1 are the critical residues for its ..
  2. Grishin A, Azhipa O, Semenov I, Corey S. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proc Natl Acad Sci U S A. 2001;98:10172-7 pubmed
    ..molecules are the growth arrest and DNA damage protein 34 (GADD34) and the Src-related protein tyrosine kinase Lyn. Here, we report that these two proteins physically and functionally interact to regulate DNA damage-induced ..
  3. Trible R, Emert Sedlak L, Smithgall T. HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J Biol Chem. 2006;281:27029-38 pubmed
    ..We expressed Fgr, Fyn, Hck, Lck, Lyn, and Yes as well as c-Src in yeast and found that each kinase was active and induced growth suppression...
  4. Iida M, Brand T, Campbell D, Li C, Wheeler D. Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor. Oncogene. 2013;32:759-67 pubmed publisher
    ..and protein expression indicated upregulation of the SFK members Yes (v-Yes-1 yamaguchi sarcoma viral oncogene) and Lyn (v-yes-1 Yamaguchi sarcoma viral-related oncogene homolog) in all Ctx(R) clones...
  5. Tauzin S, Ding H, Khatib K, Ahmad I, Burdevet D, van Echten Deckert G, et al. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood. 2008;111:2310-20 pubmed
    B-non-Hodgkin lymphomas (B-NHLs) use a raft-associated signalosome made of the constitutively active Lyn kinase, the tyrosine phosphorylated Cbp/PAG adaptor, and tyrosine phosphorylated STAT3 transcription factor...
  6. Trentin L, Frasson M, Donella Deana A, Frezzato F, Pagano M, Tibaldi E, et al. Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia. Blood. 2008;112:4665-74 pubmed publisher
    b>Lyn, a tyrosine kinase belonging to the Src family, plays a key role as a switch molecule that couples the B-cell receptor to downstream signaling...
  7. Schreiner S, Schiavone A, Smithgall T. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem. 2002;277:45680-7 pubmed
    ..phosphorylation and stimulation of DNA binding activity by five members of the Src kinase family (Src, Hck, Lyn, Fyn, and Fgr). We also observed stable STAT3.Src family kinase complex formation in this system...
  8. Tada J, Omine M, Suda T, Yamaguchi N. A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells. Blood. 1999;93:3723-35 pubmed
    ..with either antibody specifically increased tyrosine phosphorylation of the identical set of proteins of Lyn, Syk, pp60, pp69, and pp77 at the capping site...
  9. Kannan S, Audet A, Knittel J, Mullegama S, Gao G, Wu M. Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. Eur J Immunol. 2006;36:1739-52 pubmed
    b>Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis. However, the role of Lyn in infectious diseases is not clear...
  10. Bruyns E, Marie Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, et al. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med. 1998;188:561-75 pubmed
    ..Thus, TRIM represents a TCR-associated transmembrane adaptor protein which is likely involved in targeting of intracellular signaling proteins to the plasma membrane after triggering of the TCR. ..
  11. Gauld S, Cambier J. Src-family kinases in B-cell development and signaling. Oncogene. 2004;23:8001-6 pubmed
    ..Thus SFKs, most notably Lyn, play both activating and inhibitory roles in B-cell function...
  12. Su N, Peng L, Xia B, Zhao Y, Xu A, Wang J, et al. Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer. Mol Cancer. 2012;11:43 pubmed publisher
    ..are frequently deregulated in CRC and closely related to the MAPK signaling pathway, we investigated the impact of Lyn, an important member of SFKs, on CD24-induced ERK1/2 activation in CRC...
  13. Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem. 1991;266:24249-52 pubmed
    ..CSK phosphorylated p56lyn and p59fyn, which are known to be expressed in lymphoid tissues at a relatively high level...
  14. Wheeler S, Morariu E, Bednash J, Otte C, Seethala R, Chiosea S, et al. Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer. Clin Cancer Res. 2012;18:2850-60 pubmed publisher
    ..Immunoprecipitation with anti-c-Src, Lyn, Fyn, and Yes antibodies followed by immunoblotting for phosphorylation of the SFK activation site (Y416) showed ..
  15. Hibbs M, Dunn A. Lyn, a src-like tyrosine kinase. Int J Biochem Cell Biol. 1997;29:397-400 pubmed
    b>Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues...
  16. Marie Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer S, Schraven B. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem. 1997;272:16077-80 pubmed
    ..Consistent with this observation, pp55 selectively binds to isolated SH2 domains of Lck, Lyn, Src, and Fyn but not to the SH2 domains of ZAP70, Syk, Shc, SLP-76, Grb2, phosphatidylinositol 3-kinase, and c-abl ..
  17. Hirao A, Hamaguchi I, Suda T, Yamaguchi N. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 1997;16:2342-51 pubmed
    ..Chk and Lyn, but not Csk and c-Src, co-fractionated in the higher density lysate fractions of resting platelets, with Chk being ..
  18. Kharbanda S, Yuan Z, Rubin E, Weichselbaum R, Kufe D. Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. J Biol Chem. 1994;269:20739-43 pubmed
    ..In contrast, HL-60 cells responded to x-ray exposure with activation of p56/p53lyn. At a dose of 200 centigrays, induction of p56/p53lyn activity was detectable at 15 min...
  19. Zarn J, Zimmermann S, Pass M, Waibel R, Stahel R. Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line. Biochem Biophys Res Commun. 1996;225:384-91 pubmed
    ..We identified c-fgr in SW2 lysates and c-fgr and also lyn in K562 lysates...
  20. Zhao Y, He D, Saatian B, Watkins T, Spannhake E, Pyne N, et al. Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases. J Biol Chem. 2006;281:19501-11 pubmed
    ..Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated LPA-induced MMP activation, proHB-EGF ..
  21. Saksela K, Cheng G, Baltimore D. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J. 1995;14:484-91 pubmed
    ..Nef PxxP motifs show specific binding to biotinylated SH3 domains of Hck and Lyn, but not to those of other tested Src family kinases or less related proteins...
  22. Yamanashi Y, Okada M, Semba T, Yamori T, Umemori H, Tsunasawa S, et al. Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. Proc Natl Acad Sci U S A. 1993;90:3631-5 pubmed
    ..p75HS1 showed rapid tyrosine phosphorylation and association with a Src-like kinase, Lyn, after crosslinking of membrane-bound IgM...
  23. Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel E, Waddell M, et al. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 2007;128:269-80 pubmed
    ..A conserved tyrosine residue (Y88) in the Cdk-binding domain of p27 can be phosphorylated by the Src-family kinase Lyn and the oncogene product BCR-ABL. Y88 phosphorylation does not prevent p27 binding to cyclin A/Cdk2...
  24. Weng Z, Thomas S, Rickles R, Taylor J, Brauer A, Seidel Dugan C, et al. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol. 1994;14:4509-21 pubmed
    ..of the other Src SH3 ligands, also bound to the SH3 domains of the closely related protein tyrosine kinases Fyn and Lyn. However, Src- and Lyn-specific SH3-binding proteins were also detected, suggesting subtle differences in the ..
  25. Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, et al. The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987;7:237-43 pubmed
    ..from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained...
  26. Hayashi T, Umemori H, Mishina M, Yamamoto T. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature. 1999;397:72-6 pubmed
    ..signal transducers by means of their interaction with the Src-family non-receptor protein tyrosine kinase Lyn. In the cerebellum, Lyn is physically associated with the AMPA receptor and is rapidly activated following ..
  27. Gulle H, Samstag A, Eibl M, Wolf H. Physical and functional association of Fc alpha R with protein tyrosine kinase Lyn. Blood. 1998;91:383-91 pubmed
    In this report, we show that the Src family nonreceptor protein tyrosine kinase (PTK) Lyn associates with aggregated IgA Fc receptor (Fc alpha R) in the monocytic cell line THP-1...
  28. Houslay K, Christian F, MacLeod R, Adams D, Houslay M, Baillie G. Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochem J. 2017;474:597-609 pubmed publisher
    ..forms by an array of other signalling proteins, including the signalling scaffold ?-arrestin, the tyrosyl kinase Lyn, the SUMOylation E2 ligase UBC9, the dynein regulator Lis1 (PAFAH1B1) and the protein kinase Erk...
  29. Francini C, Fallacara A, Artusi R, Mennuni L, Calgani A, Angelucci A, et al. Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors. ChemMedChem. 2015;10:2027-41 pubmed publisher
    ..analogues of dasatinib and 4-aminoimidazole derivatives were synthesized and tested against the SFKs Src, Fyn, Lyn, and Yes...
  30. Maxwell M, Yuan Y, Anderson K, Hibbs M, Salem H, Jackson S. SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem. 2004;279:32196-204 pubmed a major role for the Src homology 2 domain-containing inositol 5-phosphatase (SHIP1) and Src family kinase, Lyn, in this process...
  31. Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed
    ..proteins (IgM, membrane-type 6 matrix metalloproteinase), and intracellular dually acylated signaling proteins (Lyn kinase, Galpha(i-2))...
  32. Proekt I, Miller C, Jeanne M, Fasano K, Moon J, Lowell C, et al. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016;126:3758-3771 pubmed publisher
    ..Here, we tested whether a defect in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, could combine with an Aire ..
  33. Vohidov F, Knudsen S, Leonard P, Ohata J, Wheadon M, Popp B, et al. Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors. Chem Sci. 2015;6:4778-4783 pubmed publisher
    ..In one example, a simple metallopeptide binds the Lyn SH3 domain with 6 nM affinity and exhibits functional activation of Lyn kinase under biologically relevant ..
  34. Whiting R, Payne C, Satiaputra J, Kucera N, Qiu T, Irtegun S, et al. Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1. Biochem J. 2012;442:611-20 pubmed publisher
    The tyrosine kinase Lyn is involved in oncogenic signalling in several leukaemias and solid tumours, and we have previously identified a pathway centred on Cbp [Csk (C-terminal Src kinase)-binding protein] that mediates both enzymatic ..
  35. He Y, Kapoor A, Cook S, Liu S, Xiang Y, Rao C, et al. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci. 2011;124:2153-64 pubmed publisher
    ..This pathway depends upon G(i)-protein-mediated activation and leading edge recruitment of Lyn, a non-receptor tyrosine kinase belonging to the Src kinase family...
  36. Kükenshöner T, Schmit N, Bouda E, Sha F, Pojer F, Koide A, et al. Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J Mol Biol. 2017;429:1364-1380 pubmed publisher
    ..pY ligand binding and showed strong selectivity for either the SrcA (Yes, Src, Fyn, Fgr) or SrcB subgroup (Lck, Lyn, Blk, Hck)...
  37. Ibarrola I, Vossebeld P, Homburg C, Thelen M, Roos D, Verhoeven A. Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa. Biochim Biophys Acta. 1997;1357:348-58 pubmed
    ..The GST-CT became phosphorylated in the presence of Lyn, Hck and Syk (immunoprecipitated from human neutrophils), but not in the presence of Fgr...
  38. Ferri C, Bianchini M, Bengio R, Larripa I. Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy. Blood Cells Mol Dis. 2014;52:121-5 pubmed publisher
    ..b>LYN is a src kinase protein that regulates survival and responsiveness of tumor cells by a BCR-ABL1 independent ..
  39. Rebholz H, Panasyuk G, Fenton T, Nemazanyy I, Valovka T, Flajolet M, et al. Receptor association and tyrosine phosphorylation of S6 kinases. FEBS J. 2006;273:2023-36 pubmed
    ..Our data indicate that S6 kinase is recruited into a complex with RTKs and src and becomes phosphorylated on tyrosine/s in response to PDGF or serum. ..
  40. Lee J, Tae S, Kim D, Han S, Kim W, Dhong E. Do IL-3/GM-CSF effect on the myofibroblastic differentiation of human adipose derived stromal cells?. Exp Cell Res. 2017;355:67-82 pubmed publisher
    ..b>Lyn peptide inhibitor was applied as an inhibitor...
  41. Augusto J, Truchetet M, Charles N, Blanco P, Richez C. IgE in lupus pathogenesis: Friends or foes?. Autoimmun Rev. 2018;17:361-365 pubmed publisher
    ..In the Lyn-/- and Fc?IIB-/-...
  42. Yamashita T, Yamaguchi T, Murakami K, Nagasawa S. Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE. J Biochem. 2001;129:861-8 pubmed the rapid phosphorylation of tyrosines on the beta and gamma chains of the receptor by the Src family kinase Lyn, which initiates the signaling cascades leading to secretion of inflammatory mediators...
  43. Gross B, Lee J, Clements J, Turner M, Tybulewicz V, Findell P, et al. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem. 1999;274:5963-71 pubmed
    ..Immunoprecipitation studies demonstrate association of SLP-76 with SLAP-130, Vav, Fyn, Lyn, and the FcR gamma-chain in CRP-stimulated platelets...
  44. Manie S, Beck A, Astier A, Law S, Canty T, Hirai H, et al. Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem. 1997;272:4230-6 pubmed
    ..In addition, the two molecules were detected in p53/56(Lyn) immunoprecipitates, and Lyn kinase was found to specifically bind the C-terminal proline-rich sequence of Cas in ..
  45. Zhan M, Chen G, Pan C, Gu Z, Zhao S, Liu W, et al. Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Hum Mol Genet. 2014;23:5505-17 pubmed publisher
    ..41 × 10(-4) and P= 0.02). Our findings suggest that the SNPs in XKR4 and near FOXE1 are involved in the regulation of TSH levels. ..
  46. Stanslowsky N, Reinhardt P, Glass H, Kalmbach N, Naujock M, Hensel N, et al. Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci. 2016;36:12027-12043 pubmed
    ..Recently, severe cell membrane disturbances based on depolymerized cortical actin and an elevated Lyn kinase activity in erythrocytes from ChAc patients were identified...
  47. Brunati A, Bordin L, Clari G, James P, Quadroni M, Baritono E, et al. Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites. Blood. 2000;96:1550-7 pubmed
    ..of the transmembrane protein band 3; in parallel, the activity of the immunoprecipitated tyrosine kinases Syk and Lyn is increased...
  48. Tasian S, Loh M, Hunger S. Philadelphia chromosome-like acute lymphoblastic leukemia. Blood. 2017;130:2064-2072 pubmed publisher
    ..Additional genomic alterations in Ph-like ALL activate other kinases, including BLNK, DGKH, FGFR1, IL2RB, LYN, NTRK3, PDGFRA, PTK2B, TYK2, and the RAS signaling pathway...
  49. Chan W, Sit S, Manser E. The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation. Biochem J. 2011;435:355-64 pubmed publisher
    ..The results of the present study can explain why ACK1 is responsive to so many external stimuli including RTKs and integrin ligation, since Src kinases are commonly recruited by multiple receptor systems. ..
  50. Kasahara K, Nakayama Y, Ikeda K, Fukushima Y, Matsuda D, Horimoto S, et al. Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. J Cell Biol. 2004;165:641-52 pubmed
    ..We show here that Lyn, a member of the Src-family kinases, is biosynthetically transported to the plasma membrane via the Golgi pool of ..
  51. Li Y, Chen W, Ren J, Yu W, Li Q, Yoshida K, et al. DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol Ther. 2003;2:187-93 pubmed
    ..The results also demonstrate the IL-7 induces binding of MUC1 to the Lyn tyrosine kinase...
  52. Xu C, Zhang C, Ji J, Wang C, Yang J, Geng B, et al. CD36 Deficiency Attenuates Immune-Mediated Hepatitis in Mice by Modulating the Proapoptotic Effects of CXCL10. Hepatology. 2017;: pubmed publisher
    ..Moreover, treatment of WT mice with genistein, a tyrosine kinase inhibitor that blocks CD36-Lyn signaling, attenuated Con A-induced liver injury and reduced the number of MNCs.
  53. Paolini R, Renard V, Vivier E, Ochiai K, Jouvin M, Malissen B, et al. Different roles for the Fc epsilon RI gamma chain as a function of the receptor context. J Exp Med. 1995;181:247-55 pubmed
  54. Guo Y, Shan Q, Gong Y, Lin J, Yang X, Zhou R. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer Biol Ther. 2012;13:1244-54 pubmed publisher
    ..Our results showed that oridonin inhibiting activations of LYN (one of SRC family kinases) and ABL and their downstream Akt/mTOR, Raf/MEK/ERK and STAT5 pathways, downregulated ..
  55. Corey S, Burkhardt A, Bolen J, Geahlen R, Tkatch L, Tweardy D. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1994;91:4683-7 pubmed
    ..We observed that G-CSF activated p53/p56lyn, a Src-related PTK, and p72syk, a non-Src-related PTK...
  56. Pao L, Famiglietti S, Cambier J. Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J Immunol. 1998;160:3305-14 pubmed
    ..These results indicate that phosphorylations of the tyrosines in CD79a and CD79b occur with very different stoichiometry, and the respective tyrosyl residues have distinct functions. ..
  57. Mlinaric Rascan I, Yamamoto T. B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM. FEBS Lett. 2001;498:26-31 pubmed
    ..We also demonstrate constitutive association of FAK with the Src-family kinase Lyn and with components of the BCR...
  58. Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, et al. Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Leukemia. 2007;21:403-10 pubmed
    ..In the present study, we showed the specific association of FLT3/ITD with Lyn, which led to the phosphorylation of Lyn in vivo...
  59. Dombrosky Ferlan P, Grishin A, Botelho R, Sampson M, Wang L, Rudert W, et al. Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup. Blood. 2003;101:2804-9 pubmed
    Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton...
  60. Dai X, Wu Y, Jia X, Chang Y, Wu H, Wang C, et al. hIgD promotes human Burkitt lymphoma Daudi cell proliferation by accelerated G1/S transition via IgD receptor activity. Immunol Res. 2016;64:978-87 pubmed publisher
    ..Moreover, hIgD treatment also upregulated the expression of tyrosine phosphorylation of 70 kDa protein (IgDR) and p-Lyn. Taken together, these results indicate that hIgD can induce Daudi cell proliferation through activating IgDR to ..
  61. Zhang Z, Shen K, Lu W, Cole P. The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem. 2003;278:4668-74 pubmed
  62. Narute P, Smithgall T. Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. PLoS ONE. 2012;7:e32561 pubmed publisher
    ..Nef proteins from the major HIV-1 subtypes A1, A2, B, C, F1, F2, G, H, J and K strongly activated Hck and Lyn as well as c-Src to a lesser extent, demonstrating for the first time that Src-family kinase activation is a highly ..
  63. Gamas P, Marchetti S, Puissant A, Grosso S, Jacquel A, Colosetti P, et al. Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells. Leukemia. 2009;23:1500-6 pubmed publisher
    Once cleaved by caspases, the Lyn tyrosine kinase (LynDeltaN) is relocalized from the plasma membrane to the cytoplasm of apoptotic cells, but the function of such a cleavage is incompletely understood...
  64. Ilic V, Milosević Jovcić N, Petrović S, Marković D, Bila J, Boskovic D, et al. Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma. Ann Hematol. 2007;86:905-12 pubmed
    ..There was a correlative trend between the extent of phosphorylation reduction and advanced stage of disease. Reduced phosphorylation was more pronounced with advanced stages of multiple myeloma. ..
  65. Uchiumi F, Semba K, Yamanashi Y, Fujisawa J, Yoshida M, Inoue K, et al. Characterization of the promoter region of the src family gene lyn and its trans activation by human T-cell leukemia virus type I-encoded p40tax. Mol Cell Biol. 1992;12:3784-95 pubmed
    The src family gene lyn is expressed preferentially in B lymphocytes but very little in normal T lymphocytes...
  66. Yokoyama K, Su Ih I, Tezuka T, Yasuda T, Mikoshiba K, Tarakhovsky A, et al. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J. 2002;21:83-92 pubmed
    ..mediated through the antigen receptor is dependent on activation of protein tyrosine kinases (PTKs) such as Lyn and Syk and subsequent phosphorylation of various signaling proteins...
  67. Yamasaki M, Arai H, Ashida N, Ishii K, Kita T. Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells. Biochem J. 2001;355:751-6 pubmed
    ..Pyk2 was tyrosine phosphorylated very quickly after stimulation with MCP-1. We found that Lyn, Shc and paxillin were also tyrosine phosphorylated by MCP-1...
  68. Somani A, Yuen K, Xu F, Zhang J, Branch D, Siminovitch K. The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells. J Biol Chem. 2001;276:1938-44 pubmed
    ..As CD19 tyrosine phosphorylation is modulated by the Lyn protein-tyrosine kinase, Lyn activity was evaluated in wild-type and motheaten B cells...
  69. Perez Villar J, Kanner S. Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes. J Immunol. 1999;163:6435-41 pubmed
    ..Thus, we describe a regulated interaction between Emt and PLC gamma 1, and based on our studies with individual Emt and PLC gamma 1 SH2/SH3 domains, we propose a mechanism for this association. ..
  70. Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 1998;17:6250-62 pubmed
    ..In addition, KL was shown to inhibit sustained activation of JNK induced by gamma-irradiation and concomitant irradiation-induced apoptosis. ..
  71. Uddin S, Grumbach I, Yi T, Colamonici O, Platanias L. Interferon alpha activates the tyrosine kinase Lyn in haemopoietic cells. Br J Haematol. 1998;101:446-9 pubmed
    We investigated whether the src-family tyrosine kinase Lyn is involved in the generation of interferon alpha (IFN alpha) signals in haemopoietic cells...
  72. Lorenz U, Ravichandran K, Pei D, Walsh C, Burakoff S, Neel B. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Mol Cell Biol. 1994;14:1824-34 pubmed
    ..One of these sites (Y-564) is phosphorylated in T cells in response to Lck activation. We conclude that SH-PTP1 undergoes Lck-dependent tyrosyl phosphorylation in T cells and likely plays a role in early T-cell signaling. ..
  73. Kim J, Sim S, Kim U, Nishibe S, Wahl M, Carpenter G, et al. Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. J Biol Chem. 1990;265:3940-3 pubmed
    ..We propose, therefore, that the phosphorylation of PLC-gamma by EGF receptor kinase alters its interaction with putative inhibitory proteins and leads to its activation. ..
  74. Stafford S, Lowell C, Sur S, Alam R. Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J Immunol. 2002;168:1978-83 pubmed
    ..Among the Src family members, Lyn, Hck, Fgr, and Lck are present in eosinophils, and, among these four kinases, only Lyn is associated with the IL-..
  75. Hunter Z, Yang G, Xu L, Liu X, Castillo J, Treon S. Genomics, Signaling, and Treatment of Waldenström Macroglobulinemia. J Clin Oncol. 2017;35:994-1001 pubmed publisher
    ..Non-chromosome 6q genes are also frequently deleted and include LYN, a regulator of B-cell receptor signaling...
  76. Holtrich U, Bräuninger A, Strebhardt K, Rübsamen Waigmann H. Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. Proc Natl Acad Sci U S A. 1991;88:10411-5 pubmed
    ..Six known PTKs (YES, FGR, LYN, HCK, PDGFB-R, and CSF1-R), as well as two additional members of this enzyme family, were detected in lung...