Gene Symbol: lumican
Description: lumican
Alias: LDC, SLRR2D, lumican, KSPG lumican, keratan sulfate proteoglycan lumican, lumican proteoglycan
Species: human
Products:     lumican

Top Publications

  1. Dunlevy J, Rada J. Interaction of lumican with aggrecan in the aging human sclera. Invest Ophthalmol Vis Sci. 2004;45:3849-56 pubmed
    b>Lumican is a keratan sulfate proteoglycan originally identified in cornea, but present in a variety of connective tissues where it presumably regulates collagen fibril formation and organization...
  2. Naito Z, Ishiwata T, Kurban G, Teduka K, Kawamoto Y, Kawahara K, et al. Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests. Int J Oncol. 2002;20:943-8 pubmed
    b>Lumican is a member of a small leucine-rich proteoglycan (SLRP) family and is reported to be overexpressed during the wound healing process of the cornea, and ischemic and reperfused heart...
  3. Ishiwata T, Cho K, Kawahara K, Yamamoto T, Fujiwara Y, Uchida E, et al. Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer. Oncol Rep. 2007;18:537-43 pubmed
    b>Lumican is a member of a small leucine-rich proteoglycan family and its overexpression has been reported in carcinoid tumor, breast, colorectal, neuroendocrine cell, uterine cervical and pancreatic cancers...
  4. Seomun Y, Joo C. Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signaling. Biochem Biophys Res Commun. 2008;372:221-5 pubmed publisher
    b>Lumican is a major proteoglycans of the human cornea. Lumican knock-out mice have been shown to lose corneal transparency and to display delayed wound healing...
  5. Chen Z, Wang I, Shih Y, Lin L. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. Ophthalmology. 2009;116:1920-7 pubmed publisher
    To investigate the association of genetic polymorphisms in the dermatan sulfate proteoglycan 3 (DSPG3), lumican (LUM), and decorin (DCN) genes (component genes of the sclera) with high myopia susceptibility in Taiwanese people.
  6. Nikitovic D, Chalkiadaki G, Berdiaki A, Aggelidakis J, Katonis P, Karamanos N, et al. Lumican regulates osteosarcoma cell adhesion by modulating TGF?2 activity. Int J Biochem Cell Biol. 2011;43:928-35 pubmed publisher
    ..Human osteosarcoma cell lines were recently shown to express and secrete the small leucine rich proteoglycan (SLRP) lumican, with the ability to regulate the growth and motility of these cells...
  7. Svensson L, Närlid I, Oldberg A. Fibromodulin and lumican bind to the same region on collagen type I fibrils. FEBS Lett. 2000;470:178-82 pubmed
    Fibromodulin and lumican are closely related members of the extracellular matrix leucine-rich repeat glycoprotein/proteoglycan family...
  8. Wang I, Chiang T, Shih Y, Hsiao C, Lu S, Hou Y, et al. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. Mol Vis. 2006;12:852-7 pubmed
    To study the relationships between single nucleotide polymorphisms (SNPs) of lumican, decorin, and DSPG3 genes and high myopia. One hundred and twenty adult patients with high myopia (< -10...
  9. Wang P, Li S, Xiao X, Jia X, Jiao X, Guo X, et al. High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. Invest Ophthalmol Vis Sci. 2009;50:1546-51 pubmed publisher
    Four single-nucleotide polymorphisms (SNPs) in the TGIF, lumican, TGFB1, and HGF genes have been declared to be associated with high myopia in Chinese living in southeast China, but none of them has been confirmed by additional studies...

More Information

Publications111 found, 100 shown here

  1. Brezillon S, Radwanska A, Zeltz C, Malkowski A, Ploton D, Bobichon H, et al. Lumican core protein inhibits melanoma cell migration via alterations of focal adhesion complexes. Cancer Lett. 2009;283:92-100 pubmed publisher
    b>Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity...
  2. Lin H, Kung Y, Lin Y, Sheu J, Chen B, Lan Y, et al. Association of the lumican gene functional 3'-UTR polymorphism with high myopia. Invest Ophthalmol Vis Sci. 2010;51:96-102 pubmed publisher
    The lumican gene (LUM) encodes a major extracellular component of the fibrous mammalian sclera. Alteration in the expression levels of extracellular matrix components may influence scleral shape, which in turn could affect visual acuity...
  3. Lin H, Wan L, Tsai Y, Chen W, Tsai S, Tsai F. The association between lumican gene polymorphisms and high myopia. Eye (Lond). 2010;24:1093-101 pubmed publisher
    b>Lumican (LUM) is one of the major extracellular matrix components of the sclera...
  4. Dai L, Li Y, Du C, Gong L, Han C, Li X, et al. Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese. Ophthalmic Genet. 2012;33:171-8 pubmed publisher
    To investigate whether the PAX6, Lumican, and MYOC genes are related to high myopia in Han Chinese since the association between these genes and high myopia is unclear in this patient population...
  5. Radwanska A, Litwin M, Nowak D, Baczynska D, Wegrowski Y, Maquart F, et al. Overexpression of lumican affects the migration of human colon cancer cells through up-regulation of gelsolin and filamentous actin reorganization. Exp Cell Res. 2012;318:2312-23 pubmed publisher
    ..b>Lumican, a small extracellular matrix leucine-rich proteoglycan, has been shown to inhibit human melanoma cell migration ..
  6. Park S, Mok J, Joo C. Absence of an association between lumican promoter variants and high myopia in the Korean population. Ophthalmic Genet. 2013;34:43-7 pubmed publisher
    To determine the association of single nucleotide polymorphisms (SNPs) in the promoter region of the lumican (LUM) gene with high myopic Korean patients...
  7. Coulson Thomas V, Coulson Thomas Y, Gesteira T, Andrade de Paula C, Carneiro C, Ortiz V, et al. Lumican expression, localization and antitumor activity in prostate cancer. Exp Cell Res. 2013;319:967-81 pubmed publisher
    ..b>Lumican, a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM), regulates collagen fibrillogenesis...
  8. Feng Y, Zhang Y, Zha Y, Huang J, Cai J. Association of Lumican gene polymorphism with high myopia: a meta-analysis. Optom Vis Sci. 2013;90:1321-6 pubmed publisher
    ..studies have evaluated the association between the single-nucleotide polymorphism (SNP) (rs3759223, C?T) in Lumican gene and high myopia risk in the Chinese population. However, the results have been inconsistent...
  9. Wolff G, Taranko A, Meln I, Weinmann J, Sijmonsma T, Lerch S, et al. Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis. Mol Metab. 2019;19:97-106 pubmed publisher
    ..An emerging role for the small leucine-rich proteoglycan Lumican in metabolically driven nonalcoholic fatty liver disease sparks an interest in further understanding its role in ..
  10. Tanaka H, Ohtsu A, Shiratsuki S, Kawahara Miki R, Iwata H, Kuwayama T, et al. Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. Mol Reprod Dev. 2016;83:815-826 pubmed publisher
    ..Mol. Reprod. Dev. 83: 815-826, 2016 © 2016 Wiley Periodicals, Inc. ..
  11. Heppner J, Zaucke F, Clarke L. Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I. Mol Genet Metab. 2015;114:146-55 pubmed publisher
    ..These findings have important therapeutic implications. ..
  12. Horbowicz M, Sempruch C, Kosson R, Koczkodaj D, Walas D. Effect of fluazifop-p-butyl treatment on pigments and polyamines level within tissues of non-target maize plants. Pestic Biochem Physiol. 2013;107:78-85 pubmed publisher
    ..activity of such key enzymes of polyamine biosynthesis as: ornithine decarboxylase (ODC) and lysine decarboxylase (LDC), increased in leaves treated with herbicide at the lowest concentration and decreased under the highest...
  13. Chan L, Chaili S, Filler S, Miller L, Solis N, Wang H, et al. Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus. Infect Immun. 2017;85: pubmed publisher
    ..of neutrophils (polymorphonuclear leukocytes [PMN]), macrophages (MΦ), Langerin+ dendritic cells (LDC), and natural killer (NK) cells...
  14. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Kolli T, Foster B, et al. Microproteome of dentoalveolar tissues. Bone. 2017;101:219-229 pubmed publisher
    ..collagen alpha-1(I) chain (COL1A1), collagen alpha-1(XII) chain (COL12A1), biglycan (BGN), asporin (ASPN), lumican (LUM), and fibromodulin (FMOD), served to validate the approach...
  15. Ribeiro L, Franz Montan M, Breitkreitz M, Alcântara A, Castro S, Guilherme V, et al. Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry. Eur J Pharm Sci. 2016;93:192-202 pubmed publisher
    ..The NLC6 formulation exhibited the best sustained release profile, with 59% LDC and 66% PLC released after 20h...
  16. Lambertos A, Ramos Molina B, Cerezo D, López Contreras A, Peñafiel R. The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Biochim Biophys Acta Gen Subj. 2018;1862:365-376 pubmed publisher
    ..In this study, we describe for the first time a mammalian enzyme with leucine decarboxylase activity, therefore proposing that the gene Gm853 and its protein product should be named as leucine decarboxylase (Ldc, LDC).
  17. Mühlbacher A, Sadler A, Dippel F, Juhnke C. Treatment Preferences in Germany Differ Among Apheresis Patients with Severe Hypercholesterolemia. Pharmacoeconomics. 2018;36:477-493 pubmed publisher
    ..Regarding patient preference, clinical efficacy seems to dominate. Hence, 'reduction of LDC-C in blood' was ranked highest above patient-relevant modes of administration and adverse effects...
  18. Huang S, Sun C, Hou Y, Tang Y, Zhu Z, Zhang Z, et al. A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Sci Rep. 2018;8:7630 pubmed publisher
    ..Further studies are needed to elucidate the mechanism of these potential genes and pathways in NAFLD. ..
  19. Zhang X, Wang Z, Jan S, Yang Q, Wang M. Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026. Sci Rep. 2017;7:2766 pubmed publisher
    ..Gene ontology and Kyoto Encyclopedia of Genes and Genomes assignments allowed annotation of lysine decarboxylase (LDC) and copper amine oxidase (CAO) for their conversion of L-lysine to 5-aminopentanal during HupA biosynthesis...
  20. Hu S, Parker J, Wright J. Towards unraveling the human tooth transcriptome: the dentome. PLoS ONE. 2015;10:e0124801 pubmed publisher
    ..This knowledge could prove useful in future studies of odontogenic related pathologies. ..
  21. Jeanne A, Untereiner V, Perreau C, Proult I, Gobinet C, Boulagnon Rombi C, et al. Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. Sci Rep. 2017;7:7700 pubmed publisher
    b>Lumican is a small leucine-rich proteoglycan (SLRP) being known as a key regulator of collagen fibrillogenesis. However, little attention has been given so far in studying its influence on tumor-associated matrix architecture...
  22. van der Velden M, Rijpma S, Russel F, Sauerwein R, Koenderink J. PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs. Malar J. 2015;14:76 pubmed publisher
    ..The findings show for the first time that next to PfMDR2, the PfMDR5 transport protein could play a role in emerging drug resistance. ..
  23. Chupani L, Zusková E, Niksirat H, Panáček A, Lünsmann V, Haange S, et al. Effects of chronic dietary exposure of zinc oxide nanoparticles on the serum protein profile of juvenile common carp (Cyprinus carpio L.). Sci Total Environ. 2017;579:1504-1511 pubmed publisher
    ..In summary, despite no apparent accumulation, ZnO NPs exposure to common carp probably disturbs the fish homeostasis by affecting proteins of the haematological and the immune systems. ..
  24. Bunel A, Jorssen E, Merckx E, Leroy J, Bols P, Sirard M. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. Theriogenology. 2015;83:228-37 pubmed publisher
    ..O-acyltransferase 9 (AGPAT9) (lipid metabolism), Chloride intracellular channel 3 (CLIC3), Keratin 8 (KRT8), and Lumican (LUM) (molecular transport) was observed in CC-2-8-cells (P < 0.05)...
  25. Lee H, Lee S, Lim J, Park C. Effects of food price inflation on infant and child mortality in developing countries. Eur J Health Econ. 2016;17:535-51 pubmed publisher
    ..Hence, there should be increased efforts by both LDC governments and the international community to alleviate the detrimental link between food price inflation and ..
  26. Wang D, Zhao L, Jiang J, Liu J, Wang D, Yu X, et al. Cloning, expression, and functional analysis of lysine decarboxylase in mulberry (Morus alba L.). Protein Expr Purif. 2018;151:30-37 pubmed publisher
    ..Our results provided a foundation for further studies of the enzymatic properties of LDC and established a basis for the analysis of key enzymes involved in the biosynthetic pathway of mulberry DNJ ..
  27. Li J, Yousefi K, Ding W, Singh J, Shehadeh L. Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure. Cardiovasc Res. 2017;113:633-643 pubmed publisher
  28. Chintamaneni P, Krishnamurthy P, Rao P, Pindiprolu S. Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease. Med Hypotheses. 2017;101:17-22 pubmed publisher
    ..In the current hypothesis, we propose surface modified nano-lipid drug conjugates (LDC-NPs) of PAMs of M1 receptors to improve their bioavailability in brain...
  29. Brobeil A, Dietel E, Gattenlöhner S, Wimmer M. Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51). Cell Tissue Res. 2017;368:411-423 pubmed publisher
    ..The interference of PTPIP51 in such multiprotein complexes and their PTPIP51-modulated cross-talk makes PTPIP51 an ideal target for novel drugs such as the small molecule LDC-3. Graphical Abstract á…Ÿ.
  30. Shimomura O, Oda T, Tateno H, Ozawa Y, Kimura S, Sakashita S, et al. A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC). Mol Cancer Ther. 2018;17:183-195 pubmed publisher
    ..The selected lectin was fused with a bacterial exotoxin for the construction of a lectin-drug conjugate (LDC), and its safety and antitumor effects were evaluated...
  31. Li Y, Aoki T, Mori Y, Ahmad M, Miyamori H, Takino T, et al. Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar. Cancer Res. 2004;64:7058-64 pubmed
    The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP)...
  32. Song Y, Zhang F, Zhao Y, Sun M, Tao J, Liang Y, et al. Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model. PLoS ONE. 2016;11:e0163165 pubmed publisher
    b>Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. In this study, a mutant lumican (L199P) transgenic mouse model was established to investigate the axial length changes and ultrastructural features of the sclera...
  33. Kaznowska E, Depciuch J, Szmuc K, Cebulski J. Use of FTIR spectroscopy and PCA-LDC analysis to identify cancerous lesions within the human colon. J Pharm Biomed Anal. 2017;134:259-268 pubmed publisher
    ..The obtained FTIR spectra along with the Principal Component Analysis-Linear Discriminant Analysis (PCA-LDC) as well as bandwidth analysis of the primary amide region revealed some differences between the spectra of healthy ..
  34. Naseem M, Bencúrová E, Dandekar T. The Cytokinin-Activating LOG-Family Proteins Are Not Lysine Decarboxylases. Trends Biochem Sci. 2018;43:232-236 pubmed publisher
    ..However, so far PGGxGTxxE motif-containing LDCs do not show any LDC activity...
  35. Efimova S, Chulkov E, Ostroumova O. Lipid-mediated mode of action of local anesthetics on lipid pores induced by polyenes, peptides and lipopeptides. Colloids Surf B Biointerfaces. 2018;166:1-8 pubmed publisher
    The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition ..
  36. Shen N, Dong B, Cao C, Chen Z, Liu J, Luo H, et al. Lowered phase transition temperature and excellent solar heat shielding properties of well-crystallized VO2 by W doping. Phys Chem Chem Phys. 2016;18:28010-28017 pubmed
    ..9% and Tsol = 44.8% for 2.0% W doping). ..
  37. Yamaguchi H, Ishida Y, Hosomichi J, Suzuki J, Usumi Fujita R, Shimizu Y, et al. A new approach to transfect NF-?B decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method. Int J Oral Sci. 2017;9:80-86 pubmed publisher
    ..These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue. ..
  38. McKinzie C, Goralski J, Noah T, Retsch Bogart G, Prieur M. Worsening anxiety and depression after initiation of lumacaftor/ivacaftor combination therapy in adolescent females with cystic fibrosis. J Cyst Fibros. 2017;16:525-527 pubmed publisher
    ..In these five patients, two experienced suicidal ideation and three made suicide attempts that resulted in psychiatric hospitalizations. ..
  39. Armstrong D, McGowen M, Weckle A, Pantham P, Caravas J, Agnew D, et al. The core transcriptome of mammalian placentas and the divergence of expression with placental shape. Placenta. 2017;57:71-78 pubmed publisher
    ..115 genes are important for the core functions of the placenta in all eutherian species analyzed. The molecular functions and pathways enriched in the core placenta align with the evolutionarily conserved functionality of the placenta. ..
  40. Nascimento M, Franco M, Yokaichyia F, de Paula E, Lombello C, de Araujo D. Hyaluronic acid in Pluronic F-127/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release. Int J Biol Macromol. 2018;111:1245-1254 pubmed publisher
    ..hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries...
  41. Melrose J, Fuller E, Roughley P, Smith M, Kerr B, Hughes C, et al. Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Res Ther. 2008;10:R79 pubmed publisher
    ..There were no fragments of decorin, biglycan, lumican, or keratocan that were unique to any tissue...
  42. Manoharan G, Enkvist E, Uri A. Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases. Biophys Chem. 2016;211:39-48 pubmed publisher
  43. O Halloran S, Lacy K, Woods J, Grimes C, Campbell K, Nowson C. The provision of ultra-processed foods and their contribution to sodium availability in Australian long day care centres. Public Health Nutr. 2018;21:134-141 pubmed publisher
    To categorize and assess all foods, beverages and ingredients provided over one week at Australian long day care (LDC) centres according to four levels of food processing and to assess the contribution of Na from each level of processing...
  44. Wang C, Zhao L, Liang Z, Dong B, Wan L, Wang S. New intelligent multifunctional SiO2/VO2 composite films with enhanced infrared light regulation performance, solar modulation capability, and superhydrophobicity. Sci Technol Adv Mater. 2017;18:563-573 pubmed publisher
    ..Our technique offers a simple and low-cost solution to the development of stable and visible light transparent superhydrophobic surfaces for industrial applications...
  45. Zhou K, Ge M. [Effect of lumican gene over-expression on proliferation of lung adenocarcinoma cell A549 and its mechanism]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:492-5, 497 pubmed
    To investigate the effect of the lumican gene on the proliferation of lung adenocarcinoma cell A549 and the possible mechanism...
  46. Li M, Zhai L, Zeng S, Peng Q, Wang J, Deng Y, et al. Lack of association between LUM rs3759223 polymorphism and high myopia. Optom Vis Sci. 2014;91:707-12 pubmed publisher
    Previous evidence has indicated that the lumican (LUM) gene is a candidate susceptibility gene of high myopia; however, the association between LUM promoter regions rs3759223 polymorphism and high myopia remains controversial and ..
  47. Mathes S, Mester J, Bloch W, Wahl P. Impact of high-intensity and high-volume exercise on short-term perturbations in the circulating fraction of different cell types. J Sports Med Phys Fitness. 2017;57:130-137 pubmed publisher
    ..Therefore, the purpose of the study was to examine the acute effects on circulating leukocyte differential count (LDC) by comparing the two HIT interventions with a single HVT intervention...
  48. Liu J, Zhao M, Zhuo Y, Chai Y, Yuan R. Highly Efficient Intramolecular Electrochemiluminescence Energy Transfer for Ultrasensitive Bioanalysis of Aflatoxin M1. Chemistry. 2017;23:1853-1859 pubmed publisher
    ..This sensing platform also provides a significant boost for the trace detection of other biomolecules in clinical analysis. ..
  49. Ho T, Serie D, Parasramka M, Cheville J, Bot B, Tan W, et al. Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes. Ann Oncol. 2017;28:604-610 pubmed publisher
    ..Our study implicates up regulation of ECM genes as a critical molecular event leading to visceral, bone and soft tissue metastases in ccRCC. ..
  50. Rada J, Cornuet P, Hassell J. Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins. Exp Eye Res. 1993;56:635-48 pubmed with chondroitin/dermatan sulfate side-chains (decorin) and one with keratan sulfate side-chains (lumican)...
  51. Couch F, Wang X, McWilliams R, Bamlet W, de Andrade M, Petersen G. Association of breast cancer susceptibility variants with risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:3044-8 pubmed publisher
    ..045) and LUM rs2268578 (P = 0.02). Association studies in a large pancreatic case-control study indicate that SNPs associated with breast cancer may also be associated with pancreatic cancer susceptibility and survival. ..
  52. Dunn A, Rader B, Stabb E, Mandel M. Regulation of Bioluminescence in Photobacterium leiognathi Strain KNH6. J Bacteriol. 2015;197:3676-85 pubmed publisher
    ..These experiments lay the groundwork for further study of the regulation and role of bioluminescence in P. leiognathi. ..
  53. Offman E, Phipps C, Edginton A. Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide. In Silico Pharmacol. 2016;4:3 pubmed publisher
    ..of interindividual variability in the lymphatic circulation and a unique lymphatic drainage compartment (LDC)...
  54. He D, Lu H, Li M, Chen C. Intense blue circularly polarized luminescence from helical aromatic esters. Chem Commun (Camb). 2017;53:6093-6096 pubmed publisher
    ..The molecules not only show blue fluorescence with high quantum yields in solution and films, but also exhibit intense CPL with large glum. ..
  55. Dawre S, Pathak S, Sharma S, Devarajan P. Enhanced antimalalarial activity of a prolonged release in situ gel of arteether-lumefantrine in a murine model. Eur J Pharm Biopharm. 2018;123:95-107 pubmed publisher
    ..The high efficacy with significantly reduced dose and a single administration with single shot therapy suggest ART-LUM P-LLCPr as a promising new patient friendly alternative for antimalarial therapy. ..
  56. Alessandretti R, Borba M, Benetti P, Corazza P, Ribeiro R, Della Bona A. Reliability and mode of failure of bonded monolithic and multilayer ceramics. Dent Mater. 2017;33:191-197 pubmed publisher
    ..max ZirCAD/IPS e.max Crystall./Connect/IPS e.max CAD); YLD- bilayer structure (IPS e.max ZirCAD/IPS e.max Ceram); LDC- monolithic structure (IPS e.max CAD); and YZW- monolithic structure (Zenostar Zr Translucent)...
  57. Yang M, You W, Wu S, Fan Z, Xu B, Zhu M, et al. Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. BMC Genomics. 2017;18:245 pubmed publisher
    ..carinatus predicted putative genes involved in lycopodium alkaloid biosynthesis, such as lysine decarboxylase like (LDC-like) protein and some CYP450s...
  58. Soni K, Mujtaba A, Kohli K. Lipid drug conjugate nanoparticle as a potential nanocarrier for the oral delivery of pemetrexed diacid: Formulation design, characterization, ex vivo, and in vivo assessment. Int J Biol Macromol. 2017;103:139-151 pubmed publisher
    The present work was to develop lipid drug conjugated (LDC) nanoparticles for the potential oral delivery of pemetrexed diacid (PTX) and evaluation of its in vitro, ex vivo and in vivo potentials...
  59. Xu M, Qu Y, Li Z, Li F, Xiao C, Lu L. A 6 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis B. Front Biosci (Landmark Ed). 2016;21:479-86 pubmed
    ..So CRS is a better predictor than clinical factors in differentiating high-risk versus low-risk for cirrhosis and application of CRS in clinical practice could help to reduce the rate of liver biopsy in patients with CHB. ..
  60. Pellegata N, Dieguez Lucena J, Joensuu T, Lau S, Montgomery K, Krahe R, et al. Mutations in KERA, encoding keratocan, cause cornea plana. Nat Genet. 2000;25:91-5 pubmed
    ..Our data establish that mutations in KERA cause CNA2. CNA1 patients had no mutations in these proteoglycan genes. ..
  61. Grover J, Liu C, Kao W, Roughley P. Analysis of the human lumican gene promoter. J Biol Chem. 2000;275:40967-73 pubmed
    The human lumican gene was shown to possess one major transcription start site, resulting in exon 1 of the gene giving rise to the first 74 base pairs (bp) of the 5'-untranslated region. About 1...
  62. Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, et al. Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker. Am J Dermatopathol. 2014;36:655-60 pubmed publisher
    b>Lumican, a member of the small leucine-rich proteoglycan family, regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues...
  63. Yamamoto T, Kudo M, Peng W, Naito Z. Analysis of protein expression regulated by lumican in PANC?1 cells using shotgun proteomics. Oncol Rep. 2013;30:1609-21 pubmed publisher
    b>Lumican, a member of the class II small leucine-rich proteoglycan family, regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues...
  64. Deng Z, Shi K, Song Y, Fang Y, Wu J, Li G, et al. Association between a lumican promoter polymorphism and high myopia in the Chinese population: a meta-analysis of case-control studies. Ophthalmologica. 2014;232:110-7 pubmed publisher
    To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations...
  65. Mehta A, Ramachandra C, Singh P, Chitre A, Lua C, Mura M, et al. Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model. Eur Heart J. 2017;: pubmed publisher
    ..We hypothesize that LUM might rescue also hERG trafficking defects in LQT2 and exert anti-arrhythmic effects...
  66. Grover J, Chen X, Korenberg J, Roughley P. The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. J Biol Chem. 1995;270:21942-9 pubmed
    A human lumican cDNA sequence was derived by polymerase chain reaction techniques from RNA obtained from intestine, placenta, and articular cartilage...
  67. Ishiwata T, Fujii T, Ishiwata S, Ikegawa S, Naito Z. Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells. Pathol Int. 2004;54:77-81 pubmed
    b>Lumican is a member of the small-leucine-rich proteoglycan (SLRP) family and is overexpressed during wound healing of the cornea, in ischemic and reperfused heart, and in several cancer tissues...
  68. Anderson T, Nair S, Qin H, Singlam S, Brockman A, Paiphun L, et al. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?. Antimicrob Agents Chemother. 2005;49:2180-8 pubmed
    ..However, the consistent association observed between a 3-bp indel in G7 and AS response merits further investigation...
  69. Kelemen L, Couch F, Ahmed S, Dunning A, Pharoah P, Easton D, et al. Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies. Breast Cancer Res. 2008;10:R98 pubmed publisher
    ..framework of biologic tissue in the breast, consisting of various proteins such as the proteoglycans, decorin and lumican. Altered expression of decorin and lumican is associated with breast tumors...
  70. Charlton M, Viker K, Krishnan A, Sanderson S, Veldt B, Kaalsbeek A, et al. Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. Hepatology. 2009;49:1375-84 pubmed publisher
    ..b>Lumican, a 40-kDa keratin sulfate proteoglycan that regulates collagen fibril assembly and activates transforming growth ..
  71. Kiga N, Tojyo I, Matsumoto T, Hiraishi Y, Shinohara Y, Fujita S. Expression of lumican in the articular disc of the human temporomandibular joint. Eur J Histochem. 2010;54:e34 pubmed
    b>Lumican belongs to the small leucine-rich repeat proteoglycan (SLRP) gene family and has been reported to exist in the cornea, intervertebral disc and tendon...
  72. de Wit M, Belt E, Delis van Diemen P, Carvalho B, Coupé V, Stockmann H, et al. Lumican and versican are associated with good outcome in stage II and III colon cancer. Ann Surg Oncol. 2013;20 Suppl 3:S348-59 pubmed publisher
    ..The glycoproteins versican and lumican are overexpressed in colon carcinomas and are associated with the formation of tumor stroma...
  73. Yamanaka O, Yuan Y, Coulson Thomas V, Gesteira T, Call M, Zhang Y, et al. Lumican binds ALK5 to promote epithelium wound healing. PLoS ONE. 2013;8:e82730 pubmed publisher
    b>Lumican (Lum), a small leucine-rich proteoglycan (SLRP) family member, has multiple matricellular functions both as an extracellular matrix component and as a matrikine regulating cell proliferation, gene expression and wound healing...
  74. Yasuda M, Yamaguchi S, Miyachi Y, Ishikawa O, Takahashi K. Palmoplantar collagen bundle size correlated with a characteristic spatial expression of decorin and lumican. Exp Dermatol. 2016;25:318-20 pubmed publisher
  75. Castillo E, Zheng H, Van Cabanlong C, Dong F, Luo Y, Yang Y, et al. Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells. Eur J Immunol. 2016;46:2852-2861 pubmed publisher
    ..In vitro, we found Lumican (Lum), an extracellular matrix (ECM) protein, is selectively expressed by TH17 cells among tested murine TH ..
  76. Sharma A, Muresanu D, Lafuente J, Sjöquist P, Patnaik R, Ryan Tian Z, et al. Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51. Mol Neurobiol. 2018;55:276-285 pubmed publisher
  77. Vaquerizo Hdez D, Muñoz P, R Moreno M, F Barrero D. A Low Power Consumption Algorithm for Efficient Energy Consumption in ZigBee Motes. Sensors (Basel). 2017;17: pubmed publisher
    ..approaches can be taken to make efficient use of energy in WSNs, for instance low-duty-cycling sensor networks (LDC-WSN)...
  78. Wang N, Peh Y, Magdassi S, Long Y. Surface engineering on continuous VO2 thin films to improve thermochromic properties: Top-down acid etching and bottom-up self-patterning. J Colloid Interface Sci. 2018;512:529-535 pubmed publisher
    ..The proposed surface engineering methods represent a facile and cost-effective approach for enhancing thermochromic properties that could promote the application of VO2 thin films in smart windows. ..
  79. Pendergast J, Wendroth R, Stenner R, Keil C, Yamazaki S. mPeriod2 Brdm1 and other single Period mutant mice have normal food anticipatory activity. Sci Rep. 2017;7:15510 pubmed publisher
    ..In addition, we found that two different lines of Per2 mutant mice (ldc and Brdm1) anticipated restricted food availability...
  80. Yang T, Nagy I, Mancinotti D, Otterbach S, Bundgaard Andersen T, Motawia M, et al. Transcript profiling of a bitter variety of narrow-leafed lupin to discover alkaloid biosynthetic genes. J Exp Bot. 2017;: pubmed publisher
    ..However, only the first enzyme in the pathway, lysine decarboxylase (LDC), is known. Here, we report the transcriptome of a high-QA variety of narrow-leafed lupin (L...
  81. Furuta K, Sato S, Yamauchi T, Ozawa T, Harada M, Kakumu S. Intrahepatic gene expression profiles in chronic hepatitis B and autoimmune liver disease. J Gastroenterol. 2008;43:866-74 pubmed publisher
    ..Analysis of gene expression in liver may be useful for understanding features of distinct liver diseases and for guiding disease progression, particularly in chronic hepatitis B. ..
  82. Matsuda Y, Yamamoto T, Kudo M, Kawahara K, Kawamoto M, Nakajima Y, et al. Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma. Int J Oncol. 2008;33:1177-85 pubmed
    b>Lumican is a member of a small leucine-rich proteoglycan family and is highly expressed in several types of cancer cells and/or stromal tissue...
  83. Aldave A, Rosenwasser G, Yellore V, Papp J, Sobel E, Pham M, et al. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. Invest Ophthalmol Vis Sci. 2010;51:4006-12 pubmed publisher
    ..Linkage and haplotype analyses identified 12q21.33 as a locus for PACD. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region. ..
  84. Dimasi D, Burdon K, Hewitt A, Savarirayan R, Healey P, Mitchell P, et al. Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness. Mol Vis. 2010;16:562-9 pubmed
    ..These included; aquaporin 1 (AQ1), aquaporin 5 (AQ5), decorin (DCN), fibrillin-1 (FBN1), keratocan (KERA), lumican (LUM), osteoglycin (OGN), and paired box 6 (PAX6)...
  85. Chang P, Chen Y, Lai M, Chang H, Huang C, Liu H, et al. Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in a Taiwan Chinese Han population. J Rheumatol. 2011;38:2376-81 pubmed publisher
    b>Lumican (LUM) is predominantly localized in areas of pathological fibrosis...
  86. Bubenek S, Nastase A, Niculescu A, Baila S, Herlea V, Lazar V, et al. Assessment of gene expression profiles in peripheral occlusive arterial disease. Can J Cardiol. 2012;28:712-20 pubmed publisher
    ..42, P = 0.008). Our analysis shows that NNMT, ITLN1, LUM, CFD, and TSPAN8 in combination with other known markers, such as CRP, could be evaluated as a panel of biomarkers of POAD. ..
  87. He M, Wang W, Ragoonundun D, Huang W. Meta-analysis of the association between lumican gene polymorphisms and susceptibility to high Myopia. PLoS ONE. 2014;9:e98748 pubmed publisher
    Many studies have evaluated the association between lumican (LUM) gene polymorphisms and high myopia. However, the results remain controversial...
  88. Pilling D, Vakil V, Cox N, Gomer R. TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation. Proc Natl Acad Sci U S A. 2015;112:11929-34 pubmed publisher
    ..the fibrocyte-secreted inflammatory signal tumor necrosis factor-α secrete the small leucine-rich proteoglycan lumican, and that lumican, but not the related proteoglycan decorin, promotes human fibrocyte differentiation...
  89. de Wit M, Carvalho B, Delis van Diemen P, van Alphen C, Belien J, Meijer G, et al. Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression. PLoS ONE. 2017;12:e0174768 pubmed publisher
    ..The glycoproteins versican and lumican are overexpressed at the mRNA level in colon carcinomas compared to adenomas, and are associated with the ..
  90. Martínez Muñoz A, Bello M, Romero Castro A, Rodríguez Fonseca R, Rodrigues J, Sánchez Espinosa V, et al. Binding free energy calculations using MMPB/GBSA approaches for PAMAM-G4-drug complexes at neutral, basic and acid pH conditions. J Mol Graph Model. 2017;76:330-341 pubmed publisher
    ..a chemotherapy agent and immune system suppressant, which have the highest affinities for G4-PAMAM, and Lidocaine (LDC) - used to numb tissue in a specific area and for ventricular tachycardia treatment, Metoprolol (MET) - a β1
  91. Libinaki R, Gavin P. Changes in Bioavailability of Omega-3 (DHA) through Alpha-Tocopheryl Phosphate Mixture (TPM) after Oral Administration in Rats. Nutrients. 2017;9: pubmed publisher
    ..for baseline endogenous DHA, the mean plasma DHA at 4 h produced by the LD-HTPM was nearly double (90%) the LDC control (p = 0.057)...
  92. Wang G, Ji Q, Qi B, Yu G, Liu L, Zhong J. The association of lumican polymorphisms and high myopia in a Southern Chinese population. Int J Ophthalmol. 2017;10:1516-1520 pubmed publisher
    To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population.