Gene Symbol: LTB4R2
Description: leukotriene B4 receptor 2
Alias: BLT2, BLTR2, JULF2, KPG_004, LTB4-R 2, LTB4-R2, NOP9, leukotriene B4 receptor 2, LTB4 receptor JULF2, leukotriene B4 receptor BLT2, seven transmembrane receptor BLTR2
Species: human
Products:     LTB4R2

Top Publications

  1. Yasuda D, Okuno T, Yokomizo T, Hori T, Hirota N, Hashidate T, et al. Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. FASEB J. 2009;23:1470-81 pubmed publisher
    ..Thus, these results suggest that the H8 region of hBLT2 plays an important role in transport-competent receptor folding. ..
  2. Kim G, Lee J, Cho S, Seo J, Kim J. Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2009;29:915-20 pubmed publisher
    The leukotriene B(4) (LTB(4)) receptor BLT2 is expressed in endothelium, but no clear physiological function for it has yet been identified, especially in vascular angiogenesis...
  3. Seo J, Park S, Kim J. Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2. J Biol Chem. 2012;287:13840-9 pubmed publisher
    ..In this study, we demonstrated that BLT2, a low affinity leukotriene B(4) receptor, is highly expressed in OVCAR-3 and SKOV-3 human ovarian cancer cells, ..
  4. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000;192:421-32 pubmed
    ..Shimizu. 1997. Nature. 387:620-624). Here, we report the molecular cloning of a novel GPCR for LTB(4), designated BLT2, which binds LTB(4) with a Kd value of 23 nM compared with 1...
  5. Yoo M, Song H, Woo C, Kim H, Kim J. Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. Oncogene. 2004;23:9259-68 pubmed
    ..In the present study, we observed that leukotriene B4 (LTB4) and its synthetic enzymes as well as BLT2, the low-affinity LTB4 receptor, are all elevated in Ha-Ras(V12)-transformed cells...
  6. Nilsson N, Tryselius Y, Owman C. Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14. Biochem Biophys Res Commun. 2000;274:383-8 pubmed
    ..first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb ..
  7. Kim G, Lee J, Ryu H, Wei J, Seong C, Kim J. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. J Immunol. 2010;184:3946-54 pubmed publisher
    ..We also characterized the BLT2 downstream signaling pathway and determined that BLT2-mediated IL-8 synthesis involves the upregulation of Nox1, a ..
  8. Choi J, Lee J, Kim H, Kim E, Seo J, Ko J, et al. Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. Carcinogenesis. 2010;31:543-51 pubmed publisher
    ..In the present study, we found that expression of BLT2, a low-affinity LTB4 receptor, is significantly upregulated in breast cancer cells...
  9. Bevan S, Lorenz M, Sitzer M, Markus H. Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study. Stroke. 2009;40:696-701 pubmed publisher
    ..Our study cannot exclude them as being risk factors for more advanced stages in the atherosclerotic process. ..

More Information


  1. Rocconi R, Kirby T, Seitz R, Beck R, Straughn J, Alvarez R, et al. Lipoxygenase pathway receptor expression in ovarian cancer. Reprod Sci. 2008;15:321-6 pubmed publisher
    ..tissue microarrays to stain for the proposed sites of inhibition of a LOX inhibitor (5-LOX, LTB4-BLT1, and LTB4-BLT2). 245 samples were available for interpretation...
  2. Hennig R, Osman T, Esposito I, Giese N, Rao S, Ding X, et al. BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. Br J Cancer. 2008;99:1064-73 pubmed publisher
    ..Inflammatory pathways have an important impact on tumour growth and progression. Expression of BLT2 (the second leukotriene B(4) receptor) was investigated by real-time RT-PCR and immunohistochemistry...
  3. Kato K, Yokomizo T, Izumi T, Shimizu T. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med. 2000;192:413-20 pubmed
    ..The promoter region of the BLT1 gene is localized within the open reading frame (ORF) of the BLT2 gene, which encodes a low-affinity receptor for LTB(4) (Yokomizo, T., K. Kato, K. Terawaki, T. Izumi, and T...
  4. Ryu H, Kim C, Kim J, Chung J, Kim J. UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to "BLT2-reactive oxygen species". J Invest Dermatol. 2010;130:1095-106 pubmed publisher
    ..In this study, we demonstrate that levels of BLT2, a low-affinity leukotriene B(4) receptor, and its ligands (LTB(4) and 12(S)-HETE) are greatly increased by UVB ..
  5. Lundeen K, Sun B, Karlsson L, Fourie A. Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. J Immunol. 2006;177:3439-47 pubmed
    ..mediated by two cell surface receptors, BLT1, which is predominantly expressed in peripheral blood leukocytes, and BLT2, which is expressed more ubiquitously...
  6. Choi J, Kim E, Song H, Kim C, Kim J. Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells. Free Radic Biol Med. 2008;44:624-34 pubmed
    ..In the present study, we investigated whether BLT2, a low-affinity leukotriene B(4) receptor, is involved in the generation of ROS in H-Ras(V12)-transformed ..
  7. Bevan S, Dichgans M, Wiechmann H, Gschwendtner A, Meitinger T, Markus H. Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations. Stroke. 2008;39:1109-14 pubmed publisher
    ..665; P=0.013). Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations. These risks show different magnitudes depending on ischemic stroke subtype. ..
  8. Kwon S, Ro M, Kim J. Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock. Sci Rep. 2019;9:5936 pubmed publisher
    ..acid (HETE), inflammatory lipid mediators acting on LTB4 receptors (BLT1 and BLT2), was significantly upregulated in peritoneal lavage fluid (PF) and serum from an LPS-induced endotoxic shock mouse ..
  9. Li W, Liu T, Xiong Y, Lv J, Cui X, He R. Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation. Cytokine. 2018;111:530-540 pubmed publisher
    ..Administration of BLT2 inhibitor LY255283 fails to inhibit DEP-induced lung inflammation and tumor metastasis...
  10. Guriec N, Le Jossic Corcos C, Simon B, Ianotto J, Tempescul A, Dreano Y, et al. The arachidonic acid-LTB4-BLT2 pathway enhances human B-CLL aggressiveness. Biochim Biophys Acta. 2014;1842:2096-105 pubmed publisher
    ..Since BLT2, a LTB4 membrane receptor was also more often expressed on aggressive tumor cells, and since a BLT2 inhibitor ..
  11. Park G, Kim J. LPS Up-Regulates ICAM-1 Expression in Breast Cancer Cells by Stimulating a MyD88-BLT2-ERK-Linked Cascade, Which Promotes Adhesion to Monocytes. Mol Cells. 2015;38:821-8 pubmed publisher
    ..the signaling mechanism underlying the up-regulation of ICAM-1 and found that the siRNA-mediated depletion of BLT2 markedly suppressed the LPS-induced expression of ICAM-1 in MDA-MB-231 cells and the subsequent adhesion of these ..
  12. Adel S, Kakularam K, Horn T, Reddanna P, Kuhn H, Heydeck D. Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens. Arch Biochem Biophys. 2015;565:17-24 pubmed publisher
    ..ALOX5, ALOX15, ALOX12, ALOX15B, ALOX12B, ALOXE3, COX1, COX2, LTA4H, LTC4S, ALOX5AP, CYSLTR1, CYSLTR2, BLTR1, BLTR2) from the corresponding databases...
  13. Park J, Jang J, Kim J. Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells. Biochim Biophys Acta Mol Cell Res. 2018;: pubmed publisher
    ..In this study, we found that BLT2, a cell surface GPCR for leukotriene B4 and 12‑hydroxyeicosatetraenoic acid, is highly upregulated in ..
  14. Lee A, Ro M, Kim J. Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells. J Immunol. 2016;197:2069-78 pubmed publisher
    ..In the present study, we observed that blocking leukotriene B4 receptor 2 (BLT2) completely abrogated the production of VEGF in Ag-stimulated bone marrow-derived mast cells (..
  15. Lee A, Cho K, Kim J. MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage. Exp Mol Med. 2015;47:e156 pubmed publisher
    ..We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of ..
  16. Perlikos F, Lagiou M, Papalois A, Rizou T, Kroupis C, Toumpoulis I. Lazaroid (U-74389G) ameliorates lung injury due to lipid peroxidation and nitric oxide synthase-dependent reactive oxygen species generation caused by remote systematic ischemia-reperfusion following thoracoabdominal aortic occlusion. Int J Surg. 2018;55:156-161 pubmed publisher
    ..mRNA levels of leukotrienes LB4 (LTB4R2), LC4 (LTC4S) and nitric oxide synthase (NOS) isoforms including iNOS, nNOS and eNOS were determined with real-..
  17. Nudel R, Simpson N, Baird G, O HARE A, Conti Ramsden G, Bolton P, et al. Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment. Genes Brain Behav. 2014;13:418-29 pubmed publisher
    ..The paternally-associated SNP on chromosome 14 yields a non-synonymous coding change within the NOP9 gene...
  18. Paula Silva F, Petean I, da Silva L, Faccioli L. Dual Role of 5-Lipoxygenase in Osteoclastogenesis in Bacterial-induced Apical Periodontitis. J Endod. 2016;42:447-54 pubmed publisher
    ..Root canal contamination induced the expression of messenger RNA for 5-LO and leukotriene B4 receptors BLT1 and BLT2. The administration of the 5-LO inhibitor reduced early receptor activator of nuclear factor kappa-B and receptor ..
  19. Tulah A, Parker S, Moffatt M, Wardlaw A, Connolly M, Sayers I. The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. BMC Med Genet. 2011;12:173 pubmed publisher
    ..The aim of the current study was to see if these SNPs and those spanning the receptor genes for LTB4 (LTB4R1 and LTB4R2) influence baseline lung function and COPD susceptibility/severity in smokers...
  20. Ibrahim M, Hassan A. Comparative Modeling and Evaluation of Leukotriene B4 Receptors for Selective Drug Discovery Towards the Treatment of Inflammatory Diseases. Protein J. 2018;37:518-530 pubmed publisher
    ..exerts its biological effects through stimulation of specific G protein-coupled receptors (GPCRs)-namely BLT1 and BLT2. Due to the absence of human BLT1 and BLT2 crystal structures, the current study was set to predict the 3D ..
  21. Najar M, Fayyad Kazan M, Raicevic G, Fayyad Kazan H, Meuleman N, Bron D, et al. Advanced Glycation End-Products-, C-Type Lectin- and Cysteinyl/ Leukotriene-Receptors in Distinct Mesenchymal Stromal Cell Populations: Differential Transcriptional Profiles in Response to Inflammation. Cell J. 2018;20:250-258 pubmed publisher
    ..C-type lectin receptors (CLRs, including DECTIN-1, DECTIN-2 and MINCLE), leukotriene B4 (LTB4) receptors (BLT1 and BLT2) and cysteinyl leukotrienes (CysLTs) receptors (CYSLTR1 and CYSLTR2) in distinct populations of MSCs grown under ..
  22. Okuno T, Ishitani T, Yokomizo T. Biochemical characterization of three BLT receptors in zebrafish. PLoS ONE. 2015;10:e0117888 pubmed publisher
    ..The LTB4 receptor 2 (BLT2) was originally identified as a low affinity receptor for LTB4, and, more recently, as a high affinity receptor for ..
  23. Ketelhuth D, Hermansson A, Hlawaty H, Letourneur D, Yan Z, Bäck M. The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice. Prostaglandins Other Lipid Mediat. 2015;121:105-9 pubmed publisher
    ..The low affinity BLT2 receptor for LTB4 may transduce additional pro-atherogenic signaling, but combined BLT1 and BLT2 receptor ..
  24. Zhang C, Muench D. A Nucleolar PUF RNA-binding Protein with Specificity for a Unique RNA Sequence. J Biol Chem. 2015;290:30108-18 pubmed publisher
    ..This work also reveals that APUM23, an ortholog of yeast Nop9, could provide an advanced structural backbone for Puf repeat engineering and target-specific regulation of ..
  25. Venerito M, Helmke C, Jechorek D, Wex T, Rosania R, Antweiler K, et al. Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study. BMC Gastroenterol. 2016;16:85 pubmed publisher
    Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation...
  26. Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, et al. Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. FASEB J. 2016;30:933-47 pubmed publisher
    ..Leukotriene B4 (LTB4) receptor type 2 (BLT2), mainly expressed in epithelial cells, is a GPCR for 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) and ..
  27. Zhang Y, Olson R, Brown C. Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2. J Lipid Res. 2017;58:494-503 pubmed publisher
    ..both 5-LOX-/- and BLT1-/- mice, suggesting that the low-affinity LTB4 receptor, BLT2, might be involved...
  28. Wang B, Ye K. Nop9 binds the central pseudoknot region of 18S rRNA. Nucleic Acids Res. 2017;45:3559-3567 pubmed publisher
    ..The Pumilio repeat-containing protein Nop9 briefly associates with the 90S pre-ribosome during its co-transcriptional assembly...
  29. Lee A, Ro M, Cho K, Kim J. Lipopolysaccharide/TLR4 Stimulates IL-13 Production through a MyD88-BLT2-Linked Cascade in Mast Cells, Potentially Contributing to the Allergic Response. J Immunol. 2017;199:409-417 pubmed publisher
    ..In the current study, we observed that the expression levels of leukotriene B4 receptor-2 (BLT2) and the synthesis of its ligands were highly upregulated in LPS-stimulated bone marrow-derived mast cells and that ..
  30. Luo L, Tanaka R, Kanazawa S, Lu F, Hayashi A, Yokomizo T, et al. A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications. 2017;31:13-20 pubmed publisher
    The synthetic leukotriene B4 receptor type 2 (BLT2) agonist CAY10583 (CAY) accelerates wound healing in diabetic mice by promoting keratinocyte migration. However, its effects on fibroblast activity and granulation are unknown...
  31. Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, et al. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem. 2017;292:6123-6134 pubmed publisher
    ..receptors for leukotriene B4 have been identified: the high-affinity receptor BLT1 and the low-affinity receptor BLT2. Transcriptional screening for the expression G-protein-coupled receptors in murine dorsal root ganglia showed that ..
  32. Park G, Kim J, Kim J. Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade. BMB Rep. 2016;49:232-7 pubmed
    ..7 macrophage cells. Additionally, RME inhibited IL-6 production by blocking the leukotriene B4 receptor- 2 (BLT2)-dependent-NADPH oxidase 1 (NOX1)-reactive oxygen species (ROS) cascade, leading to anti-inflammatory activity...
  33. Kim Y, Park M, Kang G, Kim H, Kim E, Byun H, et al. Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation. Prostaglandins Leukot Essent Fatty Acids. 2016;115:67-76 pubmed publisher
    ..LTB4-induced vimentin expression was suppressed by LY255283 (BLT2 antagonist). Comp A, a BLT2 agonist, further increased vimentin expression...
  34. Huang Y, Sharifpanah F, Becker S, Wartenberg M, Sauer H. Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells. Cells Tissues Organs. 2016;201:319-32 pubmed publisher
    ..Downstream of FLAP, the LTB4 receptor (BLT1) blocker U75302, the BLT2 receptor blocker LY255283 as well as the cysteinyl LT blocker BAY-u9773 inhibited vasculogenesis of ES cells...
  35. Bhatt L, Roinestad K, Van T, Springman E. Recent advances in clinical development of leukotriene B4 pathway drugs. Semin Immunol. 2017;33:65-73 pubmed publisher
    ..Two broad classes of drugs have been pursued: antagonists of the primary LTB4 receptors (BLT1 and BLT2) and inhibitors of LTA4 Hydrolase (LTA4H), the rate limiting enzyme in the production of LTB4...
  36. Tager A, Luster A. BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids. 2003;69:123-34 pubmed
    Two receptors for leukotriene B(4) (LTB(4)) have been molecularly identified: BLT1 and BLT2. Both receptors are G protein-coupled seven transmembrane domain receptors, whose genes are located in very close proximity to each other in the ..
  37. Subramanian B, Majumdar R, Parent C. The role of the LTB4-BLT1 axis in chemotactic gradient sensing and directed leukocyte migration. Semin Immunol. 2017;33:16-29 pubmed publisher
    ..We also discuss the dynamic roles of the LTB4 receptors, BLT1 and BLT2, in mediating chemotactic signaling in leukocytes and contrast them to other structurally related leukotrienes that ..
  38. Xiao M, Ai H, Li T, Rajoria P, Shahu P, Li X. Targeting of the BLT2 in chronic myeloid leukemia inhibits leukemia stem/progenitor cell function. Biochem Biophys Res Commun. 2016;472:610-6 pubmed publisher
    ..Here we show that BCR-ABL activates BLT2 in hematopoietic stem/progenitor cells to promote leukemogenesis and this involves the p53 signaling pathway...
  39. Nam Y, Min A, Kim S, Lee Y, Kim K, Song K, et al. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. Inflamm Res. 2012;61:97-102 pubmed publisher
    ..TvSP) is closely involved in interleukin (IL)-8 production in human neutrophils via LTB(4) receptors BLT1 or BLT2. T. vaginalis produced more than 714 pg/ml of LTB(4) per 1 × 10(7) trichomonads...
  40. Chiba T, Nakahara T, Hashimoto Hachiya A, Yokomizo T, Uchi H, Furue M. The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes. Exp Dermatol. 2016;25:532-6 pubmed publisher
    Leukotriene B4 (LTB4 ) receptor type 2 (BLT2) is a novel G-protein-coupled receptor, which selectively binds to 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) with stronger affinity than to LTB4 ...
  41. Kim H, Park G, Lee J, Kim J. A leukotriene B4 receptor-2 is associated with paclitaxel resistance in MCF-7/DOX breast cancer cells. Br J Cancer. 2013;109:351-9 pubmed publisher
    ..The levels of leukotriene B4 receptor-2 (BLT2) in multidrug-resistant MCF-7/DOX cells were determined using quantitative PCR and FACS analysis...
  42. Wei J, Jang J, Kim J. RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells. Biochem Biophys Res Commun. 2017;483:305-311 pubmed publisher
    ..Previously, we reported that RanBPM acts as a negative regulator of BLT2, a low-affinity leukotriene B4 receptor; thus, it interferes with BLT2-mediated cell motility...
  43. Sánchez Galán E, Gómez Hernández A, Vidal C, Martin Ventura J, Blanco Colio L, Munoz Garcia B, et al. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. Cardiovasc Res. 2009;81:216-25 pubmed publisher
    ..It acts through its two membrane receptors, BLT1 and BLT2. The aim of this study was to determine the molecular mechanism involved in the proatherogenic effect of LTB4, BLT1 ..
  44. Jang J, Wei J, Kim M, Kim J, Cho A, Kim J. Leukotriene B4 receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation. Exp Mol Med. 2017;49:e402 pubmed publisher
    ..Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays a critical role in the pathogenesis of several inflammatory diseases, ..
  45. Wei J, Kim J, Kim J. BLT2 phosphorylation at Thr355 by Akt is necessary for BLT2-mediated chemotaxis. FEBS Lett. 2011;585:3501-6 pubmed publisher
    b>BLT2, a low-affinity leukotriene B(4) (LTB(4)) receptor, is a member of the G protein-coupled receptor family and is involved in multiple cellular responses, including chemotaxis...
  46. Seo J, Cho K, Kim E, Choi M, Chung B, Kim J. Up-regulation of BLT2 is critical for the survival of bladder cancer cells. Exp Mol Med. 2011;43:129-37 pubmed publisher
    ..In this study, the role of BLT2, a receptor for leukotriene B((4)) (LTB((4))) and 12(S)-hydroxyeicosatetraenoic acid (HETE), in the survival of ..
  47. Gelfand E. Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma. Semin Immunol. 2017;33:44-51 pubmed publisher
    ..The role of BLT2 in asthma remains unclear...
  48. Iwamoto S, Koga T, Ohba M, Okuno T, Koike M, Murakami A, et al. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep. 2017;7:13267 pubmed publisher
    ..acid (12-HHT) was identified as an endogenous ligand for leukotriene B4 receptor 2 (BLT2), which is important in maintenance of epithelial homeostasis...
  49. Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, et al. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000;275:40686-94 pubmed
    ..The discovery of this new receptor should aid in further understanding the roles of LTB(4) in pathologies in these tissues and may provide a tool in identification of specific antagonists/agonists for potential therapeutic treatments. ..
  50. Park J, Park S, Kim J. Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade. Biochim Biophys Acta. 2016;1863:236-43 pubmed publisher
    ..In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and ..
  51. Pace E, Ferraro M, Di Vincenzo S, Bruno A, Giarratano A, Scafidi V, et al. Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence. Immunology. 2013;139:245-55 pubmed publisher
    ..lung fluid samples (mini-bronchoalveolar lavages) from smokers alter the expression of the LTB(4) receptor 2 (BLT2) and peroxisome proliferator-activated receptor-? (PPAR-?) in bronchial epithelial cells...
  52. Tryselius Y, Nilsson N, Kotarsky K, Olde B, Owman C. Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem Biophys Res Commun. 2000;274:377-82 pubmed
    ..Studies of intracellular calcium flow of transfected HeLa cells exposed to various leukotrienes showed that also the novel BLTR-like receptor can be activated by leukotriene B(4), and it is therefore tentatively named BLTR2.
  53. Jala V, Bodduluri S, Satpathy S, Chheda Z, Sharma R, Haribabu B. The yin and yang of leukotriene B4 mediated inflammation in cancer. Semin Immunol. 2017;33:58-64 pubmed publisher
    ..b>BLT2 mediated chemotherapy resistance, tumor promotion and metastasis are also discussed...
  54. Tulah A, Beghe B, Barton S, Holloway J, Sayers I. Leukotriene B4 receptor locus gene characterisation and association studies in asthma. BMC Med Genet. 2012;13:110 pubmed publisher
    ..The aim of this study was to characterise the genes for the two pivotal LTB4 receptors, LTB4R1 and LTB4R2 in lung tissue and determine if polymorphisms spanning these genes are associated with asthma and disease severity...
  55. Arcemisbéhère L, Sen T, Boudier L, Balestre M, Gaibelet G, Detouillon E, et al. Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimers. J Biol Chem. 2010;285:6337-47 pubmed publisher
    ..We have used the purified leukotriene B(4) receptor BLT2 as a model to investigate the capacity of receptor monomers and dimers to activate the adenylyl cyclase inhibitory ..
  56. Yokomizo T. Two distinct leukotriene B4 receptors, BLT1 and BLT2. J Biochem. 2015;157:65-71 pubmed publisher
    ..receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2. Both receptors mainly couple to pertussis toxin-sensitive Gi-like G proteins and induce cell migration...
  57. Silliman C, Kelher M, Khan S, West F, McLaughlin N, Elzi D, et al. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017;57:2690-2700 pubmed publisher
    ..HMVEC signaling via the BLT2 receptor was evaluated. Supernatants and lipids were also employed as the first event in a two-event model of ALI...
  58. Wei J, Kim J, Kim A, Jang S, Kim J. RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility. J Biol Chem. 2013;288:26753-63 pubmed publisher
    b>BLT2, a low affinity receptor for leukotriene B4 (LTB4), is a member of the G protein-coupled receptor family and is involved in many signal transduction pathways associated with various cellular phenotypes, including chemotactic motility...
  59. Kamohara M, Takasaki J, Matsumoto M, Saito T, Ohishi T, Ishii H, et al. Molecular cloning and characterization of another leukotriene B4 receptor. J Biol Chem. 2000;275:27000-4 pubmed the isolation of another gene encoding a functional G protein-coupled receptor for leukotriene B(4), named JULF2. JULF2 is a novel G protein-coupled receptor of 358 amino acids that shares 36...
  60. Pace E, Ferraro M, Mody C, Melis M, Scafidi V, Bonanno A, et al. Pleural mesothelial cells express both BLT2 and PPARalpha and mount an integrated response to pleural leukotriene B4. J Immunol. 2008;181:7292-9 pubmed
    ..Primary pleural mesothelial cells express both the proinflammatory receptor for LTB(4) BLT2, and the anti-inflammatory receptor for LTB(4), PPARalpha...
  61. Cho K, Seo J, Shin Y, Yoo M, Park C, Lee S, et al. Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor. Am J Respir Cell Mol Biol. 2010;42:294-303 pubmed publisher
    b>BLT2 is a low-affinity receptor for leukotriene B(4) (LTB(4)), a potent lipid mediator of inflammation generated from arachidonic acid via the 5-lipoxygenase pathway...
  62. Lee J, Kim G, Kim J. Androgen receptor is up-regulated by a BLT2-linked pathway to contribute to prostate cancer progression. Biochem Biophys Res Commun. 2012;420:428-33 pubmed publisher
    ..In this study, we demonstrated that AR expression was increased by a low-affinity leukotriene B(4) receptor (BLT2)-linked pathway...
  63. Kim H, Choi J, Park G, Kim J. BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells. PLoS ONE. 2012;7:e49186 pubmed publisher
    ..In this study, we report that the expression of BLT2 is markedly up-regulated in the highly aggressive human breast cancer cell lines MDA-MB-231 and MDA-MB-435 compared ..
  64. Lee J, Kim J. Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells. J Biol Chem. 2013;288:30054-63 pubmed publisher
    ..prostate cancer cells caused a time-dependent increase in the expression level of the leukotriene B4 receptor-2 (BLT2) and that BLT2 played a critical role in establishing anoikis resistance in these cells...
  65. Kim H, Choi J, Kim J. Ras promotes transforming growth factor-? (TGF-?)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells. J Biol Chem. 2014;289:22151-60 pubmed publisher
    ..In the present study we observed that BLT2, leukotriene B4 receptor-2, is markedly up-regulated by oncogenic Ras and promotes EMT in response to transforming ..
  66. Hashimoto A, Endo H, Hayashi I, Murakami Y, Kitasato H, Kono S, et al. Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis. J Rheumatol. 2003;30:1712-8 pubmed
    ..the role of leukotriene B4 (LTB4) receptors in inflammatory arthritis, we investigated the expression of BLT1 and BLT2 mRNA in synovial tissues of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods...
  67. Park G, Kim J. Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells. Oncotarget. 2015;6:5749-59 pubmed
    ..In this study, we showed that LPS upregulated the expression of leukotriene B4 receptor-2 (BLT2) and the synthesis of BLT2 ligands in MDA-MB-231 and MDA-MB-435 breast cancer cells, thereby promoting invasiveness...
  68. Saeki K, Yokomizo T. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36 pubmed publisher
    ..We identified two receptors for LTB4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2. BLT1 is expressed in various subsets of leukocytes, and analyses of BLT1-deficient mice revealed that the LTB..
  69. Qiu H, Johansson A, Sjöström M, Wan M, Schroder O, Palmblad J, et al. Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci U S A. 2006;103:6913-8 pubmed
    ..LT) B4 is a powerful chemotactic and immune modulating agent that signals via two receptors denoted BLT1 and BLT2. Here we report that BLT1 and BLT2 are expressed at low levels in an apparently silent state in human umbilical ..
  70. Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, et al. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB J. 2013;27:3306-14 pubmed publisher
    Leukotriene B4 (LTB4) has been implicated in the pathogenesis of allergic diseases. BLT2, a low-affinity LTB4 receptor, is activated by LTB4 and 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT)...