Gene Symbol: LSM10
Description: LSM10, U7 small nuclear RNA associated
Alias: MST074, MSTP074, U7 snRNA-associated Sm-like protein LSm10, U7 snRNP-specific Sm-like protein LSM10
Species: human
Products:     LSM10

Top Publications

  1. Matera A, Raimer A, Schmidt C, Kelly J, Droby G, Baillat D, et al. Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster. G3 (Bethesda). 2019;9:491-503 pubmed publisher
    ..native promoter, we previously found that Gemin2, Gemin3, Gemin5, and all nine classical Sm proteins, including Lsm10 and Lsm11, co-purify with SMN. Here, we show that CG2941 is also highly enriched in the pulldown...
  2. Pillai R, Will C, Luhrmann R, Schumperli D, Muller B. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. EMBO J. 2001;20:5470-9 pubmed
    ..Like U7 snRNA, this protein, named Lsm10, is enriched in Cajal bodies of the cell nucleus...
  3. Dominski Z, Erkmann J, Yang X, Sanchez R, Marzluff W. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002;16:58-71 pubmed
    ..Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery. ..
  4. Pillai R, Grimmler M, Meister G, Will C, Luhrmann R, Fischer U, et al. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev. 2003;17:2321-33 pubmed
    ..similar but biochemically unique Sm core in which two of these proteins, Sm D1 and D2, are replaced by Lsm10 and by another as yet unknown component...
  5. Azzouz T, Pillai R, D├Ąpp C, Chari A, Meister G, Kambach C, et al. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. J Biol Chem. 2005;280:34435-40 pubmed
    ..Here, we provide evidence that Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln ..
  6. Wagner E, Marzluff W. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006;26:6702-12 pubmed
    ..U7 snRNP contains three novel proteins, Lsm10 and Lsm11, which are part of the core U7 Sm complex, and ZFP100, a Zn finger protein that helps stabilize binding ..
  7. Fu D, Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell. 2007;28:773-85 pubmed
  8. Ghule P, Dominski Z, Lian J, Stein J, Van Wijnen A, Stein G. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. J Cell Physiol. 2009;220:129-35 pubmed publisher
    ..Histone mRNA maturation is mediated by Lsm10 containing U7snRNP complexes...
  9. Skrajna A, Yang X, Bucholc K, Zhang J, Hall T, Dadlez M, et al. U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein. RNA. 2017;23:938-951 pubmed publisher
    ..protein (SLBP) and U7 snRNP that consists of U7 snRNA and a unique Sm ring containing two U7-specific proteins: Lsm10 and Lsm11...

More Information


  1. Dominski Z, Zheng L, Sanchez R, Marzluff W. Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA. Mol Cell Biol. 1999;19:3561-70 pubmed
    ..One role of SLBP is to stabilize the interaction of the histone pre-mRNA with U7 snRNP. ..