LRSAM1

Summary

Gene Symbol: LRSAM1
Description: leucine rich repeat and sterile alpha motif containing 1
Alias: CMT2P, RIFLE, TAL, E3 ubiquitin-protein ligase LRSAM1, Tsg101-associated ligase
Species: human

Top Publications

  1. pmc Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding
    Ido Amit
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 18:1737-52. 2004
  2. ncbi The lion of the union: the pelvic wound of Joshua Lawrence Chamberlain
    W J Harmon
    Wilford Hall Medical Center, Lackland Air Force Base, University of Texas Health Science Center at San Antonio, 78250, USA
    J Urol 163:713-6. 2000
  3. ncbi Regulation of potassium channel Kir 1.1 (ROMK) abundance in the thick ascending limb of Henle's loop
    C A Ecelbarger
    Division of Endocrinology, Georgetown University, Washington, DC, USA
    J Am Soc Nephrol 12:10-8. 2001
  4. ncbi Predictive value of RIFLE classification on prognosis of critically ill patients with acute kidney injury treated with continuous renal replacement therapy
    Wen xiong Li
    Department of Surgical Intensive Care Unit, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Chin Med J (Engl) 122:1020-5. 2009
  5. pmc Medium-term follow-up of Achilles tendon lengthening in the treatment of ankle equinus in cerebral palsy
    Frederick R Dietz
    Department of Orthopaedics Surgery, University of Iowa Hospitals and Clinics Iowa City, IA 52242, USA
    Iowa Orthop J 26:27-32. 2006
  6. ncbi Immunomorphometric studies of proteinuria in individual deep and superficial nephrons of rats
    J R Hoyer
    Department of Pediatrics at the Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Lab Invest 80:1691-700. 2000
  7. doi RIFLE-based data collection/management system applied to a prospective cohort multicenter Italian study on the epidemiology of acute kidney injury in the intensive care unit
    Francesco Garzotto
    Departments of Intensive Care and Anesthesiology, St Bortolo Hospital, Viale Rodolfi 37, Vicenza, Italy
    Blood Purif 31:159-71. 2011
  8. doi Balance ability and athletic performance
    Con Hrysomallis
    Institute of Sport, Exercise and Active Living, School of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia
    Sports Med 41:221-32. 2011
  9. ncbi [Magnetic resonance imaging and pathological evaluation of vacuum sealing drainage efficacy of early treated limb gunshot]
    Ronggang Li
    The Second Affiliated Hospital of Lanzhou University, Lanzhou Gansu, 730030, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:335-9. 2010
  10. doi Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: unusual clinical associations and novel claudin16 mutation in an Egyptian family
    Mohammad Al-Haggar
    Genetics Unit, Mansoura University Children s Hospital, Mansoura, Egypt
    Clin Exp Nephrol 13:288-94. 2009

Research Grants

Detail Information

Publications153 found, 100 shown here

  1. pmc Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding
    Ido Amit
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 18:1737-52. 2004
    ..We report a novel protein, Tal (Tsg101-associated ligase), whose RING finger is necessary for multiple monoubiquitylation of Tsg101...
  2. ncbi The lion of the union: the pelvic wound of Joshua Lawrence Chamberlain
    W J Harmon
    Wilford Hall Medical Center, Lackland Air Force Base, University of Texas Health Science Center at San Antonio, 78250, USA
    J Urol 163:713-6. 2000
    ..In particular the most devastating injury was a rifle shot through the pelvis rupturing the bladder and urethra...
  3. ncbi Regulation of potassium channel Kir 1.1 (ROMK) abundance in the thick ascending limb of Henle's loop
    C A Ecelbarger
    Division of Endocrinology, Georgetown University, Washington, DC, USA
    J Am Soc Nephrol 12:10-8. 2001
    The renal outer medullary potassium channel (ROMK) of the thick ascending limb (TAL) is a critical component of the counter-current multiplication mechanism...
  4. ncbi Predictive value of RIFLE classification on prognosis of critically ill patients with acute kidney injury treated with continuous renal replacement therapy
    Wen xiong Li
    Department of Surgical Intensive Care Unit, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Chin Med J (Engl) 122:1020-5. 2009
    ..The recently proposed risk, injury, failure, loss, end-stage kidney disease (RIFLE) criteria for diagnosis and classification of AKI may provide a method for clinicians to decide the "optimal ..
  5. pmc Medium-term follow-up of Achilles tendon lengthening in the treatment of ankle equinus in cerebral palsy
    Frederick R Dietz
    Department of Orthopaedics Surgery, University of Iowa Hospitals and Clinics Iowa City, IA 52242, USA
    Iowa Orthop J 26:27-32. 2006
    ..It was hypothesized that the use of Achilles tendon lengthening (TAL) as a treatment for spastic ankle equinus during gait results in a high rate of over-weakening of the triceps surae ..
  6. ncbi Immunomorphometric studies of proteinuria in individual deep and superficial nephrons of rats
    J R Hoyer
    Department of Pediatrics at the Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Lab Invest 80:1691-700. 2000
    ..the uniformly abundant renal synthesis of Tamm-Horsfall protein (THP) in the thick ascending limb of Henle's loop (TAL)...
  7. doi RIFLE-based data collection/management system applied to a prospective cohort multicenter Italian study on the epidemiology of acute kidney injury in the intensive care unit
    Francesco Garzotto
    Departments of Intensive Care and Anesthesiology, St Bortolo Hospital, Viale Rodolfi 37, Vicenza, Italy
    Blood Purif 31:159-71. 2011
    ..The RIFLE and AKIN initiatives have provided a unifying definition for AKI, making possible large retrospective studies in ..
  8. doi Balance ability and athletic performance
    Con Hrysomallis
    Institute of Sport, Exercise and Active Living, School of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia
    Sports Med 41:221-32. 2011
    ..Surprisingly, no studies were found that compared the balance ability of rifle shooters with other athletes...
  9. ncbi [Magnetic resonance imaging and pathological evaluation of vacuum sealing drainage efficacy of early treated limb gunshot]
    Ronggang Li
    The Second Affiliated Hospital of Lanzhou University, Lanzhou Gansu, 730030, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:335-9. 2010
    ..To evaluate the effectiveness of vacuum sealing drainage (VSD) treating the penetrating wound in porcine extremity by MRI and pathological methods so as to provide theoretical basis for future clinical use...
  10. doi Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: unusual clinical associations and novel claudin16 mutation in an Egyptian family
    Mohammad Al-Haggar
    Genetics Unit, Mansoura University Children s Hospital, Mansoura, Egypt
    Clin Exp Nephrol 13:288-94. 2009
    ..is impaired tubular resorption of magnesium and calcium in the thick ascending limb of the loop of Henle (TAL) due to a genetic defect in paracellin-1 (a tight junction protein expressed in TAL)...
  11. pmc Renal dysfunction after off-pump coronary artery bypass surgery- risk factors and preventive strategies
    Gaurab Maitra
    Consultant, Department of Anesthesiology, Perioperative Medicine and Pain, Apollo Gleneagles Hospitals, Kolkata
    Indian J Anaesth 53:401-7. 2009
    ..injury, the Acute Dialysis Quality Initiative formulated the Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) classification...
  12. doi Balanced nitrogen economy as a flexible strategy on yield stabilizing and quality of aquatic food crops in wetland ecosystem
    A M Puste
    Department of Agronomy, Faculty of Agriculture, Bidhan Chandra Krishi Viswavidyalaya Agricultural University Mohanpur, 741 252, Nadia, West Bengal, India
    Sci China C Life Sci 48:980-7. 2005
    ..aquatic food crops (starch and protein-rich, most popular and remunerative) in the farmers' field of low-lying 'Tal' situation of New Alluvial Zone of Indian subtropics...
  13. ncbi Surgical treatment for rabbits' femoral arteries subjected to gunshot wounds combining with seawater immersion
    Peng Liu
    Department of Orthopaedics, Research Institute of Field Surgery and Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 8:311-6. 2005
    ..To investigate the surgical treatment methods and evaluate the outcome of gunshot wounds combining with seawater immersion in rabbits' femoral arteries...
  14. doi Impact of prealbumin levels on mortality in patients with acute kidney injury: an observational cohort study
    Jose Ramon Perez Valdivieso
    Department of Anesthesia and Critical Care, Clinica Universitaria, University of Navarra, Pamplona, Spain
    J Ren Nutr 18:262-8. 2008
    ..We evaluated the prognostic value of prealbumin (transthyretin) levels in patients with acute kidney injury (AKI)...
  15. ncbi Protection efficiency of hearing protectors against military noise from handheld weapons and vehicles
    R Pääkkönen
    Tampere Regional Institute of Occupational Health, P O Box 486, FIN 33101 Tampere, Finland
    Noise Health 7:11-20. 2005
    ..Commercial and military versions of earmuff noise attenuation were measured against rifle noise...
  16. ncbi Wound ballistics: Minié ball vs. full metal jacketed bullets--a comparison of Civil War and Spanish-American War firearms
    Paul Joseph Dougherty
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Mil Med 174:403-7. 2009
    ..This study compares the wounding characteristics of a reproduction rifle from the American Civil War to one of the Spanish-American War using the wound profile method.
  17. pmc Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis
    K Banki
    Department of Pathology, State University of New York College of Medicine, Syracuse 13210
    J Exp Med 180:1649-63. 1994
    ..was cloned and found to constitute an integral part of the coding sequence of the human transaldolase gene (TAL-H)...
  18. ncbi Balanced nitrogen economy as a flexible strategy on yield stabilizing and quality of aquatic food crops in wetland ecosystem
    A M Puste
    Department of Agronomy, Faculty of Agriculture, Bidhan Chandra Krishi Viswavidyalaya Agricultural University Mohanpur 741 252, Nadia, West Bengal, India
    Sci China C Life Sci 48:980-7. 2005
    ..aquatic food crops (starch and protein-rich, most popular and remunerative) in the farmers' field of low-lying 'Tal' situation of New Alluvial Zone of Indian subtropics...
  19. ncbi Na,K-ATPase activity in renal tubule cells from Milan hypertensive rats
    M L Melzi
    Department of Pediatrics, , Karolinska Institute, Stockholm, Sweden
    Am J Hypertens 2:563-6. 1989
    ..Na,K-ATPase activity in proximal convoluted tubules (PCT) cells and medullary thick ascending limb of Henle cells (TAL) from MHS and from the Milan normotensive rats (MNS)...
  20. ncbi Cloning and kidney cell-specific activity of the promoter of the murine renal Na-K-C1 cotransporter gene
    P Igarashi
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520
    J Biol Chem 271:9666-74. 1996
    ..proximal 5'-flanking region was ligated to a luciferase reporter gene and transfected into thick ascending limb (TAL) cells, a stable cell line derived from microdissected loops of Henle of the Tg(SV40E)Bri7 mouse...
  21. pmc Prognosis and serum creatinine levels in acute renal failure at the time of nephrology consultation: an observational cohort study
    Jose Ramon Perez-Valdivieso
    Department of Anesthesia and Critical Care, Clinica Universitaria, University of Navarra, Pamplona, Spain
    BMC Nephrol 8:14. 2007
    ..renal failure (ARF), before specialized treatment begins, and in-hospital mortality, recovery of renal function, and overall mortality at 6 months, on an equal degree of ARF severity, using the RIFLE criteria, and comorbid illnesses.
  22. doi Implications for wildlife and humans of dietary exposure to lead from fragments of lead rifle bullets in deer shot in the UK
    Jeff Knott
    Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire SG19 2DL, UK
    Sci Total Environ 409:95-9. 2010
    ..Recent evidence has shown that the problem extends to terrestrial ecosystems and to fragmented rifle bullets eaten by scavengers as well as shotgun pellets...
  23. ncbi Bicarbonate transport along the loop of Henle: molecular mechanisms and regulation
    Giovambattista Capasso
    Chair of Nephrology, Research Center for Cardiovascular Diseases, School of Medicine, Second University of Naples, Italy
    J Nephrol 15:S88-96. 2002
    ..vivo microperfusion, perfusion in vitro of the S3 segment of the proximal tubule and of the thick ascending limb (TAL) of Henle's loop, as well as quantitative PCR performed on isolated TAL, has permitted the definition of key ..
  24. ncbi Preoperative estimated glomerular filtration rate and RIFLE-classified postoperative acute kidney injury predict length of stay post-coronary bypass surgery in an Australian setting
    E M Moore
    Intensive Care Unit, St Vincent s Hospital, Melbourne, Victoria, Australia
    Anaesth Intensive Care 38:113-21. 2010
    ..Postoperative acute kidney injury was categorised using serum creatinine RIFLE criteria (no acute kidney injury, risk, injury and failure)...
  25. pmc Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study
    I Steinvall
    The Burn Unit, Department of Hand and Plastic Surgery, Linkoping University Hospital, Garnisonsvägen, Linkoping, 58185, Sweden
    Crit Care 12:R124. 2008
    ....
  26. ncbi Initiation of murine embryonic erythropoiesis: a spatial analysis
    L Silver
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, NY 14642, USA
    Blood 89:1154-64. 1997
    ..0). VYS erythropoiesis is decreased or abrogated by targeted disruption of the hematopoietic transcription factors tal-1, rbtn2, GATA-1, and GATA-2...
  27. doi The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass
    Ana Manrique
    Department of Cardiovascular Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Anesth Analg 109:45-52. 2009
    ....
  28. ncbi Efficacy of the thin agar layer method for the recovery of stressed Cronobacter spp. (Enterobacter sakazakii)
    Tareq M Osaili
    Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P O Box 3030, Irbid, 22110, Jordan
    J Food Prot 73:1913-8. 2010
    ..This study evaluated the efficacy of the thin agar layer (TAL) method for the recovery of Cronobacter cells that had been exposed to various stress conditions. Five strains of C...
  29. pmc Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa
    Andras Perl
    Department of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, USA
    Proc Natl Acad Sci U S A 103:14813-8. 2006
    ..Here, we report that male mice lacking transaldolase (TAL)(-/-) are sterile because of defective forward motility...
  30. ncbi cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP
    Pablo A Ortiz
    Hypertension and Vascular Research Division, Dept of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 290:F608-16. 2006
    NaCl absorption by the thick ascending limb of Henle's loop (TAL) is mediated by the apical Na-K-2Cl cotransporter NKCC2. cAMP increases NaCl absorption in the TAL by stimulating NKCC2...
  31. ncbi ROMK is required for expression of the 70-pS K channel in the thick ascending limb
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8026, USA
    Am J Physiol Renal Physiol 286:F490-5. 2004
    Apical potassium recycling is crucial for salt transport by the thick ascending limb (TAL). Loss-of-function mutations in the K channel, ROMK (Kir1...
  32. ncbi Characterization of serum lysosomal enzymatic activities. II. Effect of lumpy skin disease in Egyptian cows
    M A Abdalla
    Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Zagazig University, Egypt
    Dtsch Tierarztl Wochenschr 99:347-9. 1992
    ..lysosomal enzymes (LYE) in eight lumpy skin diseases (LSD) cows and same number of healthy ones were reported in Tal-El Baker village and Tal Alkabir centre, Ismailia province, Egypt...
  33. ncbi Transforming genes in duck hepatic carcinoma--mht(raf) and Ha-ras
    H Tan
    Department of Biochemistry and Molecular Biology, Shanghai Cancer Institute
    Sci Sin B 31:1325-32. 1988
    ..was performed with DNAs from 2 duck primary hepatic carcinomas (DHC 40K, 9K) and 1 tumor-adjacent liver tissue (TAL, 9N). Transfectants were found from 40K, 9K and 9N DNAs...
  34. doi Pentose phosphate pathway flux analysis for glycopeptide antibiotic vancomycin production during glucose-limited cultivation of Amycolatopsis orientalis
    Hulya Ayar-Kayali
    Faculty of Science, Department of Chemistry, Biochemistry Division, University of Dokuz Eylul, Buca, Izmir, Turkey
    Prep Biochem Biotechnol 41:94-105. 2011
    ..such as glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH), and transaldolase (TAL) activities as well as ATP- and ADP-level variations of Amycolatopsis orientalis were investigated with respect to ..
  35. ncbi Management of maxillofacial problems in self-inflicted rifle wounds
    Fuat Yuksel
    Gulhane Military Medical Academy, Haydarpasa Hospital, Department of Plastic and Reconstructive Surgery, Istanbul, Turkey
    Ann Plast Surg 53:111-7. 2004
    ..The initial anatomic reconstruction of the existing bone skeleton and the maximal use of regional tissue for cutaneous reconstruction provide an esthetic appearance that can never be duplicated by secondary reconstruction...
  36. doi Transaldolase: from biochemistry to human disease
    Anne K Samland
    The Institute of Microbiology, Universitat Stuttgart, Allmandring 31, Stuttgart, Germany
    Int J Biochem Cell Biol 41:1482-94. 2009
    The role of the enzyme transaldolase (TAL) in central metabolism, its biochemical properties, structure, and role in human disease is reviewed...
  37. ncbi Ultrastructural localization of antigens recognized by the monoclonal antibodies MB1, MB2, MT1, UCHL1, and TAL 1B5
    M G Butler
    Department of Histopathology, St Bartholomew s Hospital, London, United Kingdom
    Ultrastruct Pathol 12:301-5. 1988
    ..These distributions are different from that of immunoreactivity with TAL 1B5 (anti-HLA DR), which is present both on the cell membrane and in the cytoplasm...
  38. doi Acute kidney injury in tropical acute febrile illness in a tertiary care centre--RIFLE criteria validation
    Gopal Basu
    Department of Nephrology, Christian Medical College, Vellore, India
    Nephrol Dial Transplant 26:524-31. 2011
    Acute febrile illnesses are a common cause of tropical acute kidney injury (AKI). The incidence and severity of AKI in tropical febrile illnesses and validity of RIFLE classification are unclear.
  39. ncbi Comparison of recovery of airborne microorganisms in a dairy cattle facility using selective agar and thin agar layer resuscitation media
    Beth Ann Crozier-Dodson
    Kansas State University, Department of Animal Sciences and Industry, Manhattan 66506 1600, USA
    J Food Prot 65:1488-92. 2002
    Thin agar layer (TAL) medium was developed at Kansas State University to improve the resuscitation of injured cells and has been shown to result in higher recovery than is obtained with selective media alone for cold-, heat-, salt-, and ..
  40. ncbi Relationship between lymphocyte apoptosis and endotoxin translocation after thermal injury in rats
    Pei Yuan Xia
    Department of Pharmacy and Clinical Pharmacology, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 8:546-50. 2002
    ..To investigate the relationship between lymphocyte apoptosis in peripheral blood, spleen and mesenteric lymph nodes(MLN) and endotoxin translocation after thermal injury in rats...
  41. ncbi Acute kidney injury in the intensive care unit according to RIFLE
    Marlies Ostermann
    Department of Intensive Care, Guy s and St Thomas Hospital, London, UK
    Crit Care Med 35:1837-43; quiz 1852. 2007
    To apply the RIFLE criteria "risk," "injury," and "failure" for severity of acute kidney injury to patients admitted to the intensive care unit and to evaluate the significance of other prognostic factors.
  42. ncbi Energy cost of rifle carriage in biathlon skiing
    K W Rundell
    Sport Science and Technology Division, United States Olympic Committee, Lake Placid, NY, USA
    Med Sci Sports Exerc 30:570-6. 1998
    Since biathlon racing involves cross-country skiing while carrying a minimum weight 3.5-kg rifle, energy cost for rifle carriage could be significant to race outcome...
  43. doi Mutagenesis of 18 type III effectors reveals virulence function of XopZ(PXO99) in Xanthomonas oryzae pv. oryzae
    Congfeng Song
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Mol Plant Microbe Interact 23:893-902. 2010
    ..oryzae pv. oryzae belong to a family of transcription activator-like (TAL) effectors...
  44. pmc A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts
    L Vitelli
    Department of Hematology Oncology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Mol Cell Biol 20:5330-42. 2000
    ..erythroblasts, generated in vitro by normal adult progenitors, contain a pentamer protein complex comprising the tal-1 transcription factor heterodimerized with the ubiquitous E2A protein and linked to Lmo2, Ldb1, and retinoblastoma ..
  45. doi Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase
    Amy C Schroeder
    The Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Phytochemistry 69:1496-506. 2008
    Tyrosine ammonia lyase (TAL) catalyzes the conversion of L-tyrosine to p-coumaric acid using a 3,5-dihydro-5-methylidene-4H-imidazole-4-one (MIO) prosthetic group...
  46. doi Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 35:871-81. 2009
    ..To describe the incidence and outcomes associated with early acute kidney injury (AKI) in septic shock and explore the association between duration from hypotension onset to effective antimicrobial therapy and AKI...
  47. pmc Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008
    ..Injury Network (AKIN) criteria versus Risk, Injury, Failure, Loss of Kidney Function, End-stage Kidney Disease (RIFLE) criteria is currently unknown...
  48. ncbi RIFLE criteria for acute kidney injury in valvular surgery
    Luca Salvatore De Santo
    Chair of Cardiac Surgery, University of Foggia, Foggia, Italy
    J Heart Valve Dis 19:139-47; discussion 148. 2010
    The RIFLE classification, which defines three grades of increasing severity of acute kidney injury--risk (RIFLE R), injury (RIFLE I) and failure (RIFLE F), and two outcome classes (L, loss) and E (end-stage kidney disease)--represents a ..
  49. pmc Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients
    Patrick Lecomte
    Department of Anaesthesiology and Critical Care Medicine, Onze Lieve Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    Crit Care 12:R154. 2008
    ..and postoperative tight control of blood glucose levels on renal function after cardiac surgery based on the Risk, Injury, Failure, Loss, and End-stage kidney failure (RIFLE) criteria, and on the need for acute postoperative dialysis.
  50. ncbi Lineage-restricted regulation of the murine SCL/TAL-1 promoter
    E O Bockamp
    University of Cambridge, Department of Haematology, MRC Centre, UK
    Blood 86:1502-14. 1995
    The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment...
  51. ncbi Anti-inflammatory effect of triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on rat model of chronic bronchitis
    Jin fang Ge
    School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China
    Am J Chin Med 37:309-21. 2009
    ..Lindl. (TAL) on chronic bronchitis (CB) in rats...
  52. ncbi Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL
    K Mutig
    Department of Anatomy, Charite Universitatsmedizin, Berlin, Germany
    Am J Physiol Renal Physiol 293:F1166-77. 2007
    ..Pronounced V(2)R signal in thick ascending limb (TAL) was corroborated functionally; phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter type 2 (NKCC2) was established ..
  53. ncbi Detection of glucagon receptor mRNA in the rat proximal tubule: potential role for glucagon in the control of renal glucose transport
    J Marks
    Department of Physiology and Centre for Nephrology, Institute of Urology and Nephrology, Royal Free and University College Medical School, Middlesex Hospital, London, UK
    Clin Sci (Lond) 104:253-8. 2003
    ..renal tubular solute and fluid transport, although it is only thought to act directly on the thick ascending limb (TAL) and collecting duct (CD)...
  54. doi Effects of abomasal infusion of linseed oil on responses to glucose and insulin in holstein cows
    J A A Pires
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 91:1378-90. 2008
    ..design, fed to meet maintenance requirements, and infused abomasally with either linseed oil (LIN) or tallow (TAL) at a rate of 0.54 g/kg of body weight per d for 5.5 d...
  55. ncbi Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Biol Chem 277:37881-7. 2002
    ..1; Kcnj1) gene is believed to encode the apical small conductance K(+) channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD)...
  56. ncbi Contribution of acute kidney injury toward morbidity and mortality in burns: a contemporary analysis
    Steven G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT 06516, USA
    Am J Kidney Dis 49:517-23. 2007
    ..It is not known whether milder forms of AKI have prognostic importance in burns...
  57. doi Phase 1 study of human plasma-derived plasmin (TAL-05-00018) in hemodialysis graft occlusion
    Richard Shlansky-Goldberg
    University of Pennsylvania, Philadelphia, PA, USA
    Thromb Res 122:S16-9. 2008
    ..Percutaneous intervention involves thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of the stenotic lesions...
  58. ncbi Effect of luminal atrial natriuretic peptide on chloride reabsorption in mouse cortical thick ascending limb: inhibition by endothelin
    C Bailly
    Department of Cellular Biology, CEA Saclay, Gif sur Yvette, France
    J Am Soc Nephrol 11:1791-7. 2000
    ..undertaken to investigate a possible effect of the peptide on chloride reabsorption (JCl) in thick ascending limb (TAL)...
  59. ncbi [Na-K-Cl cotransporters and "salt-sensitive" arterial hypertension]
    R P Garay
    INSERM U400,
    Arch Mal Coeur Vaiss 92:1033-8. 1999
    ..of DS rats seems to be hyperactivity of cotransporter Na-K-Cl BSC1 at the thick ascending limb of Henle's loop (TAL)...
  60. doi Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs
    Agustin Gonzalez-Vicente
    Dept of Physiology and Biophysics, Case Western Reserve Univ School of Medicine, 10900 Euclid Ave, MS 4970, Robbins E 526, Cleveland, OH 44106 4970
    Am J Physiol Renal Physiol 305:F1306-14. 2013
    Thick ascending limbs (TAL) reabsorb 30% of the filtered NaCl load. Na enters the cells via apical Na-K-2Cl cotransporters and Na/H exchangers and exits via basolateral Na pumps...
  61. pmc TAL Effectors Specificity Stems from Negative Discrimination
    Basile I M Wicky
    Laboratory for Biomolecular Modeling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    PLoS ONE 8:e80261. 2013
    Transcription Activator-Like (TAL) effectors are DNA-binding proteins secreted by phytopathogenic bacteria that interfere with native cellular functions by binding to plant DNA promoters...
  62. ncbi Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases
    Vesna Simunovic
    Pharmaceutical Biotechnology, Saarland University, Im Stadtwald, 66123 Saarbrucken, Germany
    Chembiochem 7:1206-20. 2006
    ..ORFs in conjunction with genetic studies suggests the involvement of four type I polyketide synthases (PKSs; TaI, TaL, TaO, and TaP), one major hybrid PKS/NRPS (Ta-1), and a number of monofunctional enzymes similar to the ones ..
  63. doi Impact of cystatin C and RIFLE on renal function assessment after cardiac surgery
    Marcia Cristina da Silva Magro
    1University of Brasilia, Brasilia, DF, Brazil
    Biol Res Nurs 15:451-8. 2013
    ..The aim of the present study was to characterize the discriminatory power of cystatin C and the RIFLE and Acute Kidney Injury Network (AKIN) criteria for the assessment of renal dysfunction after cardiac surgery...
  64. doi Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles
    A M Stelzleni
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA
    J Anim Sci 91:4510-20. 2013
    ..1% of ration DM (TAL), 2) a 50:50 ratio of supplemental fat from a combination of tallow at 2.1% and FFECS at 12...
  65. ncbi Acute kidney injury in the paediatric intensive care unit: identification by modified RIFLE criteria
    W F Hui
    Department of Paediatrics, Queen Elizabeth Hospital, Jordan, Hong Kong
    Hong Kong Med J 19:13-9. 2013
    To evaluate the prevalence and outcome of acute kidney injury in paediatric intensive care units using the modified RIFLE score (pRIFLE).
  66. doi Outcome predictors of allogeneic hematopoietic stem cell transplant
    Wen Chi Yang
    Chang Gung University College of Medicine, Taoyuan, Taiwan
    Am J Med Sci 345:33-8. 2013
    ..analyzed the outcomes of patients receiving allogeneic HSCT and identified the association between prognosis and RIFLE (risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function and end-stage renal ..
  67. doi Classification and staging of acute kidney injury: beyond the RIFLE and AKIN criteria
    Zaccaria Ricci
    Department of Pediatric Cardiac Surgery, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Nat Rev Nephrol 7:201-8. 2011
    ..endorsed by the Acute Dialysis Quality Initiative led to the publication of a consensus definition for AKI--the RIFLE criteria (Risk, Injury, Failure, Loss of function, and End-stage renal disease)--which was designed to standardize ..
  68. doi Recurrent posterior shoulder instability after rifle shooting
    Jae Ho Cho
    Ajou University School of Medicine, Suwon, Korea
    Orthopedics 35:e1677-9. 2012
    b>Rifle shooting produces a sudden counterforce against the body thorough the anterior shoulder, which may produce a traumatic injury in soldiers. Posterior instability of the shoulder can occur in soldiers who practice rifle shooting...
  69. pmc Acute Renal Failure in Patients with Severe Falciparum Malaria: Using the WHO 2006 and RIFLE Criteria
    Vipa Thanachartwet
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithee Road, Ratchathevee, Bangkok 10400, Thailand
    Int J Nephrol 2013:841518. 2013
    There are limited data on the application of the RIFLE criteria among patients with severe malaria...
  70. doi Designer TAL effectors induce disease susceptibility and resistance to Xanthomonas oryzae pv. oryzae in rice
    Ting Li
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Mol Plant 6:781-9. 2013
    b>TAL (transcription activator-like) effectors from Xanthomonas bacteria activate the cognate host genes, leading to disease susceptibility or resistance dependent on the genetic context of host target genes...
  71. doi Are lead-free hunting rifle bullets as effective at killing wildlife as conventional lead bullets? A comparison based on wound size and morphology
    Anna Trinogga
    Leibniz Institute for Zoo and Wildlife Research, P O 601103, D 10252 Berlin, Germany
    Sci Total Environ 443:226-32. 2013
    Fragmentation of the lead core of conventional wildlife hunting rifle bullets causes contamination of the target with lead...
  72. doi Potential for reducing the numbers of SiPM readout surfaces of laser-processed X'tal cube PET detectors
    Yoshiyuki Hirano
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Phys Med Biol 58:1361-74. 2013
    We are developing a three-dimensional (3D) position-sensitive detector with isotropic spatial resolution, the X'tal cube...
  73. pmc The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization
    Stephen R Stockdale
    Department of Microbiology, University College Cork, Cork, Ireland
    J Biol Chem 288:5581-90. 2013
    Lactococcal phages Tuc2009 and TP901-1 possess a conserved tail fiber called a tail-associated lysin (referred to as Tal(2009) for Tuc2009, and Tal(901-1) for TP901-1), suspended from their tail tips that projects a peptidoglycan ..
  74. pmc Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors
    Guillermo B Silva
    School of Chemistry Science, Catholic Univ of Córdoba, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Cordoba, Argentina
    Am J Physiol Renal Physiol 304:F376-81. 2013
    The energy required for active Na chloride reabsorption in the thick ascending limb (TAL) depends on oxygen consumption and oxidative phosphorylation (OXP)...
  75. pmc Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens
    T E Adams
    Immunology 50:613-24. 1983
    Two monoclonal antibodies, TAL-1B5 and TAL-3C3, specific for human Ia alpha-chain subunits have been produced by fusing P3/NSI/1-Ag4-1 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with purified alpha-chains...
  76. doi The Acute Kidney Injury Network (AKIN) criteria applied in burns
    Kevin K Chung
    Clinical Division, United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Burn Care Res 33:483-90. 2012
    ..classification system is a modification of the previously described risk, injury, failure, loss, and end-stage (RIFLE) criteria. Among other modifications, the AKIN staging requires an absolute serum creatinine change of 0...
  77. doi An investigation into the behaviour of air rifle pellets in ballistic gel and their interaction with bone
    G Wightman
    School of Contemporary Sciences, University of Abertay Dundee, Bell Street, Dundee DD5 3JS, Scotland, United Kingdom
    Forensic Sci Int 200:41-9. 2010
    ..The present study was therefore carried out to improve understanding of the terminal ballistic behaviour of air rifle pellets. Pellets were fired into ballistic gel under a variety of conditions...
  78. pmc Novel insights regarding the operational characteristics and teleological purpose of the renal Na+-K+-Cl2 cotransporter (NKCC2s) splice variants
    Geneviève M Brunet
    Department of Medicine, Faculty of Medicine, Nephrology Group, L Hôtel Dieu de Research Center, Laval University, Quebec, Canada G1R 2J6
    J Gen Physiol 126:325-37. 2005
    ..polytopic protein that forms homooligomeric complexes in the apical membrane of the thick ascending loop of Henle (TAL)...
  79. pmc Study of transaldolase deficiency in urine samples by capillary LC-MS/MS
    Gyorgy Vas
    SUNY Upstate Medical University, Department of Medicine, NY 13210, USA
    J Mass Spectrom 41:463-9. 2006
    Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway (PPP). TAL deficiency is a newly recognized cause of liver cirrhosis...
  80. doi Addition of transcription activator-like effector binding sites to a pathogen strain-specific rice bacterial blight resistance gene makes it effective against additional strains and against bacterial leaf streak
    Aaron W Hummel
    Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA 50011, USA
    New Phytol 195:883-93. 2012
    Xanthomonas transcription activator-like (TAL) effectors promote disease in plants by binding to and activating host susceptibility genes...
  81. ncbi Relationships between postural balance, rifle stability and shooting accuracy among novice rifle shooters
    K Mononen
    Research Institute for Olympic Sports, Jyvaskyla, Finland
    Scand J Med Sci Sports 17:180-5. 2007
    ..e., postural balance and gun barrel stability, among novice rifle shooters in intra- and inter-individual levels...
  82. doi Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins
    Carsten A Wagner
    Institute of Physiology, Center for Integrative Human Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 294:F1373-80. 2008
    ..by loss-of-function mutations in proteins mediating or regulating salt transport in the thick ascending limb (TAL) of Henle's loop...
  83. pmc Incidence and predictors of nephrotoxicity associated with intravenous colistin in overweight and obese patients
    Timothy P Gauthier
    Department of Pharmacy Practice, Nova Southeastern University College of Pharmacy, Fort Lauderdale, Florida, USA
    Antimicrob Agents Chemother 56:2392-6. 2012
    ..Severity of acute kidney injury was defined by RIFLE (risk, injury, failure, loss, and end-stage kidney disease) criteria...
  84. doi Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
    Ning Sun
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Biosyst 8:1255-63. 2012
    b>TAL effector nucleases (TALENs) represent a new class of artificial nucleases capable of cleaving long, specific target DNA sequences in vivo and are powerful tools for genome editing with potential therapeutic applications...
  85. pmc Thoracic artificial lung impedance studies using computational fluid dynamics and in vitro models
    Rebecca E Schewe
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Ann Biomed Eng 40:628-36. 2012
    ..This study sought to reduce TAL impedance using computational fluid dynamics (CFD)...
  86. pmc Structural basis for sequence-specific recognition of DNA by TAL effectors
    Dong Deng
    State Key Laboratory of Bio membrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    Science 335:720-3. 2012
    b>TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a central domain of tandem repeats...
  87. ncbi Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells
    Chiz Tzung Chang
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, and Kidney Research Institue, Chang Gung Memorial Hospital, Taipei, Taiwan
    Nephrol Dial Transplant 22:1033-40. 2007
    ..The major site of Mg2+ transport is the thick ascending limb (TAL), where 70% of the ultrafiltrable Mg2+ is reabsorbed paracellularly...
  88. doi The characterization of transaldolase gene tal from Pichia stipitis and its heterologous expression in Fusarium oxysporum
    Jin Xia Fan
    Department of Life Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
    Mol Biol Rep 38:1831-40. 2011
    The 972 bp length of transaldolase gene tal was cloned from Pichia stipitis CICC1960, encoding a 323 amino acid protein with a calculated molecular mass of 35.36 kDa and isoelectric point of 5.20...
  89. ncbi Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
    K Langlands
    Section of Hematology Oncology, Children s Hospital of Pittsburgh, The, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 272:19785-93. 1997
    ..the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the hematopoietic factors (Scl/Tal-1, Tal-2, and Lyl-1) were tested in a quantitative yeast 2-hybrid assay...
  90. ncbi The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5
    K Banki
    Department of Medicine, State University of New York Health Science Center, College of Medicine, Syracuse 13210, USA
    Genomics 45:233-8. 1997
    Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates...
  91. ncbi Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney
    S Nielsen
    Department of Cell Biology, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol 275:F885-93. 1998
    ..BSC-1, is believed to mediate the apical component of transcellular NaCl absorption in the thick ascending limb (TAL) of Henle's loop...
  92. ncbi Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop
    G H Kim
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    Am J Physiol 276:F96-F103. 1999
    To investigate whether the enhancement of thick ascending limb (TAL) NaCl transport in response to long-term increases in circulating vasopressin concentration is associated with increased expression levels of the apical Na-K-2Cl ..
  93. doi Evaluation of sepsis/systemic inflammatory response syndrome, acute kidney injury, and RIFLE criteria in two tertiary hospital intensive care units in Turkey
    Itir Yegenaga
    Department of Internal Medicine, Kocaeli University Medical School, Kocaeli, Turkey itiryegenaga hotmail com
    Nephron Clin Pract 115:c276-82. 2010
    ..Patients were classified as those without AKI (n = 60; 43.20%) and those with AKI (n = 79; 56.80%) based on the RIFLE (Risk, Injury, Failure, Loss, End-stage renal disease) criteria...
  94. doi Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor
    Jose I Pueyo
    School of Life Sciences, University of Sussex, Falmer, Brighton, UK
    Dev Biol 355:183-93. 2011
    ..Here we show that the non-canonical tarsal-less (tal) gene (also known as pri), which encodes for four small related peptides, is expressed in the N-activated region ..
  95. pmc A biomechanical rationale for C1-ring osteosynthesis as treatment for displaced Jefferson burst fractures with incompetency of the transverse atlantal ligament
    Heiko Koller
    Department for Traumatology and Sport Injuries, Paracelsus Medical University Salzburg, Mullner Hauptstrasse 48, 5020 Salzburg, Austria
    Eur Spine J 19:1288-98. 2010
    ..data serving evidence that C1-RO is safe in displaced JBF with proven rupture of the transverse atlantal ligament (TAL)...
  96. pmc Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner
    Kerim Mutig
    Department of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biol Chem 286:30200-10. 2011
    Active transport of NaCl across thick ascending limb (TAL) epithelium is accomplished by Na(+),K(+),2Cl(-) cotransporter (NKCC2)...
  97. ncbi Acute kidney injury in AIDS: frequency, RIFLE classification and outcome
    G B Silva Júnior
    Divisão de Nefrologia, Hospital Universitario Walter Cantidio, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Braz J Med Biol Res 43:1102-8. 2010
    ..present study was to evaluate the characteristics of acute kidney injury (AKI) in AIDS patients and the value of RIFLE classification for predicting outcome...
  98. ncbi Distinct mechanisms direct SCL/tal-1 expression in erythroid cells and CD34 positive primitive myeloid cells
    E O Bockamp
    University of Cambridge, Department of Haematology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 272:8781-90. 1997
    The SCL/tal-1 gene (hereafter designated SCL) encodes a basic helix-loop-helix transcription factor which is pivotal for the normal development of all hematopoietic lineages and which is expressed in committed erythroid, mast, and ..
  99. ncbi Prospective multicenter study on epidemiology of acute kidney injury in the ICU: a critical care nephrology Italian collaborative effort (NEFROINT)
    P Piccinni
    Department of Intensive Care and Anesthesiology, S Bortolo Hospital, Vicenza, Italy
    Minerva Anestesiol 77:1072-83. 2011
    ..The RIFLE consensus definition has provided a unifying definition for AKI leading to large retrospective studies in ..
  100. doi [Importance of the molecular diagnosis in the screening of alpha-thalassemia]
    Domenico Dell'Edera
    Laboratorio di Genetica Medica, Presidio Ospedaliero Madonna delle Grazie, Matera
    Recenti Prog Med 102:302-6. 2011
    ..This paper highlights that in the presence of a alfa2-Tal (-α/αα), called the silent, the biochemical diagnosis turns out to be insufficient...
  101. ncbi T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein
    A N Goldfarb
    University of Minnesota Hospital Department of Laboratory Medicine and Pathology, Minneapolis
    Blood 80:2858-66. 1992
    SCL/tal is a putative oncogene originally identified through its involvement in the translocation t(1;14)(p32;q11) present in the leukemic cell line DU.528...

Research Grants70

  1. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2000
    ..The elements critical to TGF adaptation are a) changes in loop of Henle - thick ascending limb (TAL) reabsorptive capacity, b) macula densa signal transmission and c) adaptations of the glomerular hemodynamic ..
  2. APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
    William Wechter; Fiscal Year: 2001
    ..Based on the very high potency of LLU-alpha inhibiting the 70 pS K+ channel of TAL cells of the loop of Henle, it is now known where this receptor resides...
  3. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2010
    ..The preliminary results indicate that deficiency of transaldolase (TAL, encoded by the TALDO1 genomic locus), an enzyme of the pentose phosphate pathway (PPP), is an important cause of ..
  4. 3D MRI-Based Modeling for Computer-Aided Right Ventricle Remodeling Surgery
    Dalin Tang; Fiscal Year: 2010
    ..The MRI's to be used for this study are clinically indicated studies as part of the care of these patients and are currently obtained under an approved protocol where Dr. Tal Geva is the principal investigator.
  5. Nanostructured Zirconia Ceramics for Joint Prosthetics
    ANTHONY SUTORIK; Fiscal Year: 2004
    ..S. supplier of toughened zirconia hip joints in the U.S. but no longer produces them. Tal Materials has learned to produce large quantities of very high quality nanosized 3YSZ powders using controlled ..
  6. MOLECULAR BIOLOGY OF TRANSALDOLASE
    Andras Perl; Fiscal Year: 2004
    DESCRIPTION (Copied from Applicant Abstract): Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) which generates two essential metabolites: ribose 5-phosphate for nucleotide synthesis and NADPH for biosynthetic ..
  7. Multiscale Model of Neural Control of Breathing
    ILYA A contact RYBAK; Fiscal Year: 2010
    ..Smith, NINDS, NIH, intramural), mathematics, system analysis and bioengineering (Alona Ben-Tal, Massey University, NZ), and computational neuroscience and neural control (Ilya A. Rybak, Drexel University)...
  8. Prevention of Kidney Stone Crystal Retention
    JACK KLEINMAN; Fiscal Year: 2007
    ..Polyanions and small to intermediate MW polymers containing other functional groups that may interfere with crys- tal attachment will be tested for their ability to inhibit calcium oxalate crystal deposition in rats treated with ..
  9. Prevention of Kidney Stone Crystal Retention
    Jack G Kleinman; Fiscal Year: 2010
    ..Polyanions and small to intermediate MW polymers containing other functional groups that may interfere with crys- tal attachment will be tested for their ability to inhibit calcium oxalate crystal deposition in rats treated with ..
  10. Development of a Total Artificial Lung
    Robert H Bartlett; Fiscal Year: 2010
    ..An implantable, total artificial lung (TAL) that could function for 3-6 months would allow more patients to undergo successful lung transplantation, just as ..
  11. Development of a Total Artificial Lung
    Robert H Bartlett; Fiscal Year: 2010
    ..An implantable, total artificial lung (TAL) that could function for 3-6 months would allow more patients to undergo successful lung transplantation, just as ..
  12. Development of a Total Artificial Lung
    Robert Bartlett; Fiscal Year: 2009
    ..An implantable, total artificial lung (TAL) that could function for 3-6 months would allow more patients to undergo successful lung transplantation, just as ..
  13. Development of a Total Artificial Lung
    Robert Bartlett; Fiscal Year: 2009
    ..An implantable, total artificial lung (TAL) that could function for 3-6 months would allow more patients to undergo successful lung transplantation, just as ..
  14. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2007
    ..Because the brains of children with L1 mutations resemble those of children with tal alcohol syndrome, it is possible that inhibition of L1-mediated cell adhesion contributes to the eratogenic effects ..
  15. INTRAOPERATIVE MEASUREMENT IN CEREBRAL PALSY SURGERY
    Richard Lieber; Fiscal Year: 2003
    ..prospective clinical study which compares two methods for equinus deformity correction: tendoachilles lengthening (TAL) and gastrocnemius-soleus recession (GSR, "Strayer" procedure)...
  16. Regulation of HIV transcription by Tat and P-TEPb
    TSAFI PE ERY; Fiscal Year: 2004
    ..P-TEFb (cyclin T1/CDK9) is a cellular transcription elongation factor that cooperates with the viral protein Tal to attain processive transcription of the HIV genome...
  17. Transcriptional Control of Hematopoietic Stem Cells
    EMERY BRESNICK; Fiscal Year: 2005
    ..HoxB4, Bmi 1, beta-catenin, TAL-1 and GATA-2 transcription factors control HSC self-renewal and/or function...
  18. BIOCHEMICAL AND BIOPHYSICAL NATURE OF CLAUDIN-16 AND CLAUDIN-19 CHANNELS
    Jianghui Hou; Fiscal Year: 2010
    ..We have found that the two claudins co-localize in the thick ascending limb (TAL), interact and form a cation-selective protein complex...
  19. MOLECULAR BIOLOGY OF TRANSALDOLASE
    Andras Perl; Fiscal Year: 1999
    ..We have cloned the human transaldolase (TAL-H) cDNA, the genomic locus, produced a functional recombinant protein, and generated specific antibodies...
  20. Molecular Mechanisms of Tissue Stem Cell Plasticity
    Stuart Orkin; Fiscal Year: 2004
    ..Aim 3 will assess whether expression of a hematopoietic (SCL/tal-1) or myogenic (MyoD) regulatory gene alters in vivo HSC or muscle stem cell plasticity...