Gene Symbol: LRRTM4
Description: leucine rich repeat transmembrane neuronal 4
Alias: leucine-rich repeat transmembrane neuronal protein 4
Ko J, Pramanik G, Um J, Shim J, Lee D, Kim K, et al
. PTPÏƒ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015;112:1874-9 pubmed publisher
..to proteolytically cleaved GPC-4 and formed additional complex with leucine-rich repeat transmembrane protein 4 (LRRTM4) in rat brains...
Kawamura Y, Suga A, Fujimaki T, Yoshitake K, Tsunoda K, Murakami A, et al
. LRRTM4-C538Y novel gene mutation is associated with hereditary macular degeneration with novel dysfunction of ON-type bipolar cells. J Hum Genet. 2018;63:893-900 pubmed publisher
..C538Y mutation in a post-synaptic gene, LRRTM4. WES analysis revealed seven rare genetic variations in patients...
Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, et al
. Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proc Natl Acad Sci U S A. 2018;115:E5382-E5389 pubmed publisher
..long-term potentiation (LTP), an impairment that was rescued by simultaneous expression of LRRTM2, but not LRRTM4. Mutation or deletion of the intracellular tail of LRRTM2 did not affect its ability to rescue LTP, while point ..
Paatero A, Rosti K, Shkumatov A, Sèle C, Brunello C, Kysenius K, et al
. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016;55:914-26 pubmed publisher
..In addition, LRRTM3 and LRRTM4 have been found to be ligands for heparan sulfate proteoglycans, including glypican...
Liu Q, Wang X, Liu Y, Wei M, Chen L. A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus. Arch Oral Biol. 2016;68:61-5 pubmed publisher
..protein 2 (SRGAP2), vesicle-associated membrane protein 4 (VAMP4), leucine rich repeat transmembrane neuronal 4 (LRRTM4) and lysine (K)-specific demethylase5C (KDM5C)...
Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
..All LRRTMs, except LRRTM4, are located in the introns of different alpha-catenin genes, suggesting coevolution of these two gene families...
De Wit J, O Sullivan M, Savas J, Condomitti G, Caccese M, Vennekens K, et al
. Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. Neuron. 2013;79:696-711 pubmed publisher
..Here we identify the heparan sulfate (HS) proteoglycan glypican as a receptor for LRRTM4 using an unbiased proteomics-based approach. Glypican binds LRRTM4, but not LRRTM2, in an HS-dependent manner...
Li X, Cornelis M, Liang L, Song F, De Vivo I, Giovannucci E, et al
. A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. Carcinogenesis. 2016;37:1138-1143 pubmed
..001) including those mapping to the genes LRRTM4, ATF3 and DCLRE1C in women and POTEA in men...