Gene Symbol: LRRTM3
Description: leucine rich repeat transmembrane neuronal 3
Alias: leucine-rich repeat transmembrane neuronal protein 3
Species: human
Products:     LRRTM3

Top Publications

  1. Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
    ..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
  2. Smith J, Meehan M, Crean J, McCann A. Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest. Cell Mol Life Sci. 2011;68:2493-8 pubmed publisher
    ..Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease. ..
  3. Majercak J, Ray W, Espeseth A, Simon A, Shi X, Wolffe C, et al. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:17967-72 pubmed
    ..we assessed 15,200 genes for their role in Abeta42 secretion and identified leucine-rich repeat transmembrane 3 (LRRTM3) as a neuronal gene that promotes APP processing by BACE1...
  4. Sousa I, Clark T, Holt R, Pagnamenta A, Mulder E, Minderaa R, et al. Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Mol Autism. 2010;1:7 pubmed publisher
    ..Here we present an association study analysing the roles of four promising candidate genes - LRRTM1 (2p), LRRTM3 (10q), LRRN1 (3p) and LRRN3 (7q) - in order to identify common genetic risk factors underlying ASDs...
  5. Edwards T, Pericak Vance M, Gilbert J, Haines J, Martin E, Ritchie M. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:721-35 pubmed publisher
    ..with Alpha-2-Macroglobulin (A2M), which mediates the clearance of Abeta, and Leucine-Rich Repeat Transmembrane-3 (LRRTM3), a nested gene in Alpha-3 Catenin (CTNNA3) which binds Presenilin-1...
  6. Wang J, Yu J, Jiang T, Tan M, Wang H, Tan L, et al. Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese. Exp Gerontol. 2014;52:18-22 pubmed publisher
    The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease...
  7. Reitz C, Conrad C, Roszkowski K, Rogers R, Mayeux R. Effect of genetic variation in LRRTM3 on risk of Alzheimer disease. Arch Neurol. 2012;69:894-900 pubmed
    To explore the role of leucine-rich repeat transmembrane 3 (LRRTM3) in late-onset Alzheimer disease (AD) by independent genetic epidemiologic and functional studies...
  8. Laakso T, Muggalla P, Kysenius K, Lauren J, Paatero A, Huttunen H, et al. LRRTM3 is dispensable for amyloid-? production in mice. J Alzheimers Dis. 2012;31:759-64 pubmed publisher
    Neuronal LRRTM3 (leucine-rich repeat transmembrane 3) protein has been reported to promote amyloid-? protein precursor (A?PP) processing and LRRTM3 is a candidate gene in late-onset Alzheimer's disease...
  9. Lincoln S, Allen M, Cox C, Walker L, Malphrus K, Qiu Y, et al. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). PLoS ONE. 2013;8:e64164 pubmed publisher
    Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family...

More Information


  1. Um J, Choi T, Kang H, Cho Y, Choii G, Uvarov P, et al. LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding. Cell Rep. 2016;14:808-822 pubmed publisher
    ..They have also been implicated in neuropsychiatric diseases. Here, we focus on LRRTM3, showing that two distinct LRRTM3 variants generated by alternative splicing regulate LRRTM3 interaction with PSD-..
  2. Paatero A, Rosti K, Shkumatov A, Sèle C, Brunello C, Kysenius K, et al. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016;55:914-26 pubmed publisher
    ..In addition, LRRTM3 and LRRTM4 have been found to be ligands for heparan sulfate proteoglycans, including glypican...