Gene Symbol: LRRTM2
Description: leucine rich repeat transmembrane neuronal 2
Alias: leucine-rich repeat transmembrane neuronal protein 2, leucine-rich repeat neuronal 2 protein, leucine-rich repeat transmembrane neuronal 2 protein
Species: human
Products:     LRRTM2

Top Publications

  1. Yamagata M, Duan X, Sanes J. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Front Mol Neurosci. 2018;11:142 pubmed publisher is required for three synaptic organizers, neurologin1 (NLGL1), leucine-rich repeat transmembrane protein 2 (LRRtm2), and Cell Adhesion Molecule 1 (Cadm1/SynCAM) to stimulate presynaptic differentiation, assayed by clustering of ..
  2. Yamagata A, Goto Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, et al. Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction. Nat Commun. 2018;9:3964 pubmed publisher
    ..Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4)...
  3. Parvin S, Takeda R, Sugiura Y, Neyazaki M, Nogi T, Sasaki Y. Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis. Neurosci Res. 2018;: pubmed publisher
    ..We found that leucine-rich repeat transmembrane neuronal 2 (LRRTM2)-conjugated beads, which promotes synchronized presynapse formation, induced simultaneous accumulation of FMRP and ..
  4. Hayer S, Bading H. Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2. J Biol Chem. 2015;290:5523-32 pubmed publisher
    ..Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling...
  5. Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, et al. Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proc Natl Acad Sci U S A. 2018;115:E5382-E5389 pubmed publisher
    ..Here, we take advantage of the generation of a LRRTM1 and LRRTM2 double conditional knockout mouse (LRRTM1,2 cKO) to examine the role of LRRTM1,2 at mature excitatory ..
  6. Li M, Zhai G, Gu X, Sun K. ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells. Gene. 2018;672:93-105 pubmed publisher
    ..For the 'acute-exposure' settings that HMEC-1 were treated with 12.9??M cisplatin for 6, 24 and 48?h, ATF3, LRRTM2, VCAM1 and PAPPA were identified as potential key genes in endothelial damage, while for the 'chronic-exposure' ..
  7. Paatero A, Rosti K, Shkumatov A, Sèle C, Brunello C, Kysenius K, et al. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016;55:914-26 pubmed publisher
    ..We report here the crystal structure of a thermostabilized mouse LRRTM2, with a Tm 30 °C higher than that of the wild-type protein...
  8. Chamma I, Letellier M, Butler C, Tessier B, Lim K, Gauthereau I, et al. Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin. Nat Commun. 2016;7:10773 pubmed publisher
    ..synaptic adhesion molecules neurexin-1β, neuroligin-1 (Nlg1) and leucine-rich-repeat transmembrane protein 2 (LRRTM2) in a dual-colour configuration with GFP nanobody, and show that these proteins are diffusionally trapped at ..
  9. Naito Y, Tanabe Y, Lee A, Hamel E, Takahashi H. Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization. Sci Rep. 2017;7:42548 pubmed publisher NRX-interacting proteins including neuroligin1/2 (NLG1/2) and the leucine-rich repeat transmembrane protein LRRTM2. Although AβOs do not interfere with the binding of NRX1β to NLG1 or LRRTM2, time-lapse imaging revealed that Aβ..

More Information


  1. Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
    ..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
  2. Graubert T, Payton M, Shao J, Walgren R, Monahan R, Frater J, et al. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. PLoS ONE. 2009;4:e4583 pubmed publisher
    ..2 genes are not common events in MDS, and implicate haploinsufficiency of multiple genes as the relevant genetic consequence of this common deletion. ..
  3. Kask M, Pruunsild P, Timmusk T. Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms. Biochem Biophys Res Commun. 2011;411:56-61 pubmed publisher
    ..CTNNA2 contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 genes, respectively...