Gene Symbol: LRRTM1
Description: leucine rich repeat transmembrane neuronal 1
Alias: leucine-rich repeat transmembrane neuronal protein 1, leucine-rich repeat transmembrane neuronal 1 protein
Species: human
Products:     LRRTM1

Top Publications

  1. Francks C, Maegawa S, Lauren J, Abrahams B, Velayos Baeza A, Medland S, et al. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry. 2007;12:1129-39, 1057 pubmed
    ..We found significant association of a haplotype upstream of the gene LRRTM1 (Leucine-rich repeat transmembrane neuronal 1) with a quantitative measure of human handedness in a set of ..
  2. Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
    ..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
  3. Monavarfeshani A, Stanton G, Van Name J, Su K, Mills W, Swilling K, et al. LRRTM1 underlies synaptic convergence in visual thalamus. elife. 2018;7: pubmed publisher
    ..we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence...
  4. Sajan S, Rubenstein J, Warchol M, Lovett M. Identification of direct downstream targets of Dlx5 during early inner ear development. Hum Mol Genet. 2011;20:1262-73 pubmed publisher
    ..using a Dlx5 antibody confirmed direct binding of Dlx5 to promoters of seven of these (Atbf1, Bmper, Large, Lrrtm1, Msx1, Ebf1 and Lhx1) in a cell line over-expressing Dlx5...
  5. Yamagata A, Goto Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, et al. Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction. Nat Commun. 2018;9:3964 pubmed publisher
    ..Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4)...
  6. Arning L, Ocklenburg S, Schulz S, Ness V, Gerding W, Hengstler J, et al. PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness. PLoS ONE. 2013;8:e67251 pubmed publisher assumed to be influenced by a number of genetic and environmental factors, we performed an association study of LRRTM1 rs6733871 and a number of polymorphisms in PCSK6 and different aspects of handedness assessed with the Edinburgh ..
  7. Hayer S, Bading H. Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2. J Biol Chem. 2015;290:5523-32 pubmed publisher
    ..Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling...
  8. Schroeder A, Vanderlinden J, Vints K, Ribeiro L, Vennekens K, Gounko N, et al. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Neuron. 2018;99:329-344.e7 pubmed publisher
    ..At Schaffer collateral (SC) inputs, FLRT2, LRRTM1, and Slitrk1 are postsynaptically localized and differentially regulate synaptic structure and function...
  9. Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, et al. Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proc Natl Acad Sci U S A. 2018;115:E5382-E5389 pubmed publisher
    ..Here, we take advantage of the generation of a LRRTM1 and LRRTM2 double conditional knockout mouse (LRRTM1,2 cKO) to examine the role of LRRTM1,2 at ..

More Information


  1. Leach E, Prefontaine G, Hurd P, Crespi B. The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population. J Hum Genet. 2014;59:332-6 pubmed publisher
    ..Single-nucleotide polymorphisms (SNPs) of the imprinted gene LRRTM1 have previously been associated with schizophrenia risk and with handedness in individuals with dyslexia...
  2. Oczkowicz M, Szmatoła T, Piórkowska K, Ropka Molik K. Variant calling from RNA-seq data of the brain transcriptome of pigs and its application for allele-specific expression and imprinting analysis. Gene. 2018;641:367-375 pubmed publisher
    ..Finally, we have used these SNPs for the verification of the imprinted status of the INPP5f variant 2, LRRTM1 and HM13 genes in pigs by Sanger sequencing...
  3. McManus C, Nicholls M, Vallortigara G. Editorial commentary: is LRRTM1 the gene for handedness?. Laterality. 2009;14:1-2 pubmed publisher
  4. Kask M, Pruunsild P, Timmusk T. Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms. Biochem Biophys Res Commun. 2011;411:56-61 pubmed publisher
    ..Recently, a haplotype upstream of one of the human LRRTM genes, LRRTM1 that resides in CTNNA2, was shown to be associated with handedness and schizophrenia...
  5. Brucato N, DeLisi L, Fisher S, Francks C. Hypomethylation of the paternally inherited LRRTM1 promoter linked to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2014;165B:555-63 pubmed publisher
    ..The gene LRRTM1 (chromosome 2p12) has previously been linked and associated with schizophrenia in a parent-of-origin manner in a ..
  6. Sousa I, Clark T, Holt R, Pagnamenta A, Mulder E, Minderaa R, et al. Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Mol Autism. 2010;1:7 pubmed publisher
    ..Here we present an association study analysing the roles of four promising candidate genes - LRRTM1 (2p), LRRTM3 (10q), LRRN1 (3p) and LRRN3 (7q) - in order to identify common genetic risk factors underlying ASDs...
  7. Um J, Choi T, Kang H, Cho Y, Choii G, Uvarov P, et al. LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding. Cell Rep. 2016;14:808-822 pubmed publisher
    The four members of the LRRTM family (LRRTM1-4) are postsynaptic adhesion molecules essential for excitatory synapse development. They have also been implicated in neuropsychiatric diseases...
  8. Paatero A, Rosti K, Shkumatov A, Sèle C, Brunello C, Kysenius K, et al. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016;55:914-26 pubmed publisher
    ..We also determined affinities of the thermostabilized LRRTM2 and wild-type LRRTM1 and LRRTM2 for neurexin-β1 with and without Ca(2+)...
  9. Beste C, Arning L, Gerding W, Epplen J, Mertins A, Röder M, et al. Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1. Mol Neurobiol. 2018;55:2268-2274 pubmed publisher
    ..To this end, we examined potential effects of the imprinted gene leucine-rich repeat transmembrane neuronal 1 (LRRTM1) on attentional biasing processes in a forced attention dichotic listening task in 983 healthy adult participants ..
  10. Crow T, Close J, Dagnall A, Priddle T. Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007). Laterality. 2009;14:3-10 pubmed publisher the cerebral torque, which we take to be the anatomical basis of language, we are unconvinced by the data for LRRTM1 presented by Francks et al...
  11. Silipigni R, Cattaneo E, Baccarin M, Fumagalli M, Bedeschi M. Rare interstitial deletion of chromosome 2p11.2p12. Report of a new patient with developmental delay and unusual clinical features. Eur J Med Genet. 2016;59:39-42 pubmed publisher
    ..The common deleted region involves several genes (CTNNA2, LRRTM1, REEP1), highly expressed in the nervous system...
  12. Francks C. Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity. Laterality. 2009;14:11-6 pubmed publisher
    ..a recent study in which the first putative genetic effect on human handedness was identified (the imprinted locus LRRTM1 on human chromosome 2). In this issue of Laterality, Tim Crow and colleagues present a critique of that study...
  13. Voikar V, Kulesskaya N, Laakso T, Lauren J, Strittmatter S, Airaksinen M. LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour. Behav Brain Res. 2013;238:69-78 pubmed publisher
    ..b>LRRTM1-knockout mice have subtle morphological deficits in excitatory hippocampal synapses and were suggested to have ..
  14. Ludwig K, Mattheisen M, Mühleisen T, Roeske D, Schmal C, Breuer R, et al. Supporting evidence for LRRTM1 imprinting effects in schizophrenia. Mol Psychiatry. 2009;14:743-5 pubmed publisher