LRPAP1

Summary

Gene Symbol: LRPAP1
Description: LDL receptor related protein associated protein 1
Alias: A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP, alpha-2-macroglobulin receptor-associated protein, 39 kDa receptor-associated protein, low density lipoprotein receptor-related protein associated protein 1, low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Species: human
Products:     LRPAP1

Top Publications

  1. Willnow T, Rohlmann A, Horton J, Otani H, Braun J, Hammer R, et al. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J. 1996;15:2632-9 pubmed
    ..low density lipoprotein (LDL) receptor-related protein (LRP) forms a complex with a receptor-associated protein (RAP) within the secretory pathway...
  2. Kanekiyo T, Bu G. Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. J Biol Chem. 2009;284:33352-9 pubmed publisher
    ..The receptor-associated protein (RAP) is a specialized chaperone for members of the low density lipoprotein receptor family...
  3. Kanekiyo T, Zhang J, Liu Q, Liu C, Zhang L, Bu G. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci. 2011;31:1644-51 pubmed publisher
    ..Our findings demonstrate that LRP1 and HSPG function in a cooperative manner to mediate cellular A? uptake and define a major pathway through which A? gains entry to neuronal cells. ..
  4. Yang L, Liu C, Zheng H, Kanekiyo T, Atagi Y, Jia L, et al. LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. J Neuroinflammation. 2016;13:304 pubmed
    ..functions in microglia were also assessed in the presence of LRP1 antagonist, the receptor-associated protein (RAP)...
  5. Zhang M, Li Y, Wei X, Tian F, Ouyang F, Zhao S, et al. Indispensable role of lipoprotein bound-ApoE in adipogenesis and endocytosis induced by postprandial TRL. Biochem Biophys Res Commun. 2017;493:298-305 pubmed publisher
    ..Receptor associated protein (RAP), heparin or both were added to inhibit low density lipoprotein receptor family receptors, heparan sulfate ..
  6. Kurasawa J, Shestopal S, Woodle S, Ovanesov M, Lee T, Sarafanov A. Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII. Biochemistry. 2015;54:481-9 pubmed publisher
    ..cluster I, and only three ligands, including the LRP chaperone alpha-2 macroglobulin receptor-associated protein (RAP), bind cluster III...
  7. Santana J, Marzolo M. The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation. Biochem J. 2017;474:3137-3165 pubmed publisher
    ..as well as membrane trafficking through the regulation of the activity of small GTPases, including the Rho and Rap families and molecules involved in cell polarity...
  8. Kim S, Cheon S, Kim E, Lee J, Kam E, Kim J, et al. Isoflurane Postconditioning Inhibits tPA-Induced Matrix Metalloproteinases Activation After Hypoxic Injury via Low-Density Lipoprotein Receptor-Related Protein and Extracellular Signal-Regulated Kinase Pathway. Neurochem Res. 2017;42:1533-1542 pubmed publisher
    ..and NF-?B pathway in isoflurane postconditioning was assessed using LRP inhibitor (receptor-associated protein, RAP) and ERK-1/2 inhibitor (PD98059)...
  9. Mantuano E, Azmoon P, Brifault C, Banki M, Gilder A, Campana W, et al. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017;130:1364-1374 pubmed publisher
    ..the signature of signaling events elicited by proinflammatory LRP1 ligands, such as receptor-associated protein (RAP), which included sustained I?B? phosphorylation and activation of all 3 MAP kinases (ERK1/2, c-Jun kinase, and p38 ..

More Information

Publications139 found, 100 shown here

  1. Castro Núñez L, Koornneef J, Rondaij M, Bloem E, van der Zwaan C, Mertens K, et al. Cellular uptake of coagulation factor VIII: Elusive role of the membrane-binding spikes in the C1 domain. Int J Biochem Cell Biol. 2017;89:34-41 pubmed publisher
    ..FVIII endocytosis did not occur in the presence of receptor-associated-protein (RAP), but FVIII remained visible as a striated fluorescent pattern at the cell borders...
  2. Sen A, Nelson T, Alkon D. ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation. J Neurosci. 2015;35:7538-51 pubmed publisher
    ..Blocking low-density lipoprotein receptor-related protein 1 (LRP-1) receptor with receptor-associated protein (RAP) or LRP-1 siRNA abolished the ApoE effects...
  3. Laatsch A, Ragozin S, Grewal T, Beisiegel U, Joerg H. Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). Eur J Cell Biol. 2004;83:113-20 pubmed
    ..RT-PCR, Western blot and immunofluorescence analysis, and it dramatically decreases receptor-associated protein (RAP) uptake...
  4. Nakamura K, Kishida T, Ejima A, Tateyama R, Morishita S, Ono T, et al. Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes. Biometals. 2018;: pubmed publisher
    ..H-89, a specific PKA inhibitor, abrogated bLF-induced UCP1 gene expression. Moreover, receptor-associated protein (Rap), an antagonist of low-density lipoprotein receptor-related protein 1 (LRP1), significantly reduced bLF-induced ..
  5. Lin S, Racz J, Tai M, Brooks K, Rzeczycki P, Heath L, et al. A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs. Pharm Res. 2016;33:72-82 pubmed publisher
    ..endocytosis (RME) for the uptake of exogenous tPA with and without an LRP1 inhibitor, receptor associated protein (RAP), and quantitatively compared it to the liver...
  6. Brifault C, Gilder A, Laudati E, Banki M, Gonias S. Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation. J Biol Chem. 2017;292:18699-18712 pubmed publisher
    ..By contrast, the LRP1 ligand, receptor-associated protein (RAP), robustly activated microglia, and its activity was attenuated in LRP1-deficient cells...
  7. Qian J, Chopp M, Liu Z. Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA. PLoS ONE. 2016;11:e0168345 pubmed publisher
    ..The synergistic effect was inhibited by U0126, an ERK inhibitor, and receptor associated protein (RAP), a low density lipoprotein receptor related protein 1 (LRP1) ligand antagonist...
  8. Ruan X, Chen T, Wang X, Li Y. Suxiao Jiuxin Pill protects cardiomyocytes against mitochondrial injury and alters gene expression during ischemic injury. Exp Ther Med. 2017;14:3523-3532 pubmed publisher
    ..3 (Nos3), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit ? (Pik3ca), phospholipase A2 group 4A, rap guanine nucleotide exchange factor 4 and ryanodine receptor 2 were detected using reverse transcription-..
  9. Johanns M, Lemoine P, Janssens V, Grieco G, Moestrup S, Nielsen R, et al. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Sci Rep. 2017;7:4328 pubmed publisher
    ..Addition of receptor-associated protein (RAP), a natural LRP antagonist, caused accumulation of endogenous proMMP-2 and TIMP-2 in conditioned media...
  10. Lok K, Manzanero S, Arumugam T. Neuronal low-density lipoprotein receptor-related protein 1 (LRP1) enhances the anti-apoptotic effect of intravenous immunoglobulin (IVIg) in ischemic stroke. Brain Res. 2016;1644:192-202 pubmed publisher
    ..In ischemic neurons, LRP1 antagonism by receptor associated protein (RAP) enhances the activation of pro-death signaling pathways such as nuclear factor-kappa B (NF-?B), mitogen-activated ..
  11. Mantuano E, Brifault C, Lam M, Azmoon P, Gilder A, Gonias S. LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A. 2016;113:1369-74 pubmed publisher
    ..The antagonists, receptor-associated protein (RAP) and lactoferrin (LF), and LRP1-specific antibody had the entirely opposite effect, promoting inflammatory mediator ..
  12. Ruan H, Chai Z, Shen Q, Chen X, Su B, Xie C, et al. A novel peptide ligand RAP12 of LRP1 for glioma targeted drug delivery. J Control Release. 2018;279:306-315 pubmed publisher
    The receptor associated protein (RAP) is a 39?kDa chaperone protein, binding tightly to low-density lipoprotein receptor-related protein-1 (LRP1) that is overexpressed in glioma, tumor neovasculature, vasculogenic mimicry (VM), the blood-..
  13. Niego B, Broughton B, Ho H, Sobey C, Medcalf R. LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH. Fluids Barriers CNS. 2017;14:33 pubmed publisher
    ..rt-PA (10 mg/kg) or its vehicle, with or without the LDL receptor antagonist, receptor-associated protein (RAP; 2 mg/kg), were intravenously injected at reperfusion after 0.5 or 4 h of middle cerebral artery occlusion (MCAo)...
  14. Li D, Pang H, Song J, Zhao Y, Zhang B, Ma X, et al. Receptor-associated protein promotes t-PA expression, reduces PAI-1 expression and improves neurorecovery after acute ischemic stroke. J Neurol Sci. 2015;350:84-9 pubmed publisher
    Receptor-associated protein (RAP) is a receptor antagonist that inhibits ligand interactions with the receptors that belong to the low density lipoprotein receptor gene family...
  15. Fan J, Stukas S, Wong C, Chan J, May S, Devalle N, et al. An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res. 2011;52:1605-16 pubmed publisher
    ..Receptor-associated-protein (RAP)-mediated inhibition of apoE receptor function blocked appearance of the 8...
  16. Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
    ..Receptor associated protein 80 (RAP-80) ubiquitin interacting motif agarose was used in a pull-down assay to obtain K63 -polyubiquitinated ..
  17. de Andrade A, Arruda R, Torres M, Pieri N, Leite T, Celeghini E, et al. Nitric oxide in frozen-thawed equine sperm: Effects on motility, membrane integrity and sperm capacitation. Anim Reprod Sci. 2018;: pubmed publisher
    ..The l-arginine treatments reduced MOT, PROG, RAP and LIN only at time 0?min compared to the control and L-NAME...
  18. Fazavana J, Muczynski V, Proulle V, Wohner N, Christophe O, Lenting P, et al. LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex. J Thromb Haemost. 2016;14:2458-2470 pubmed publisher
    ..factor antibodies, whereas binding of FVIIa-antithrombin but not FVIIa was inhibited by the LRP1-antagonist GST-RAP. Additional experiments revealed binding of both FVIIa and FVIIa-antithrombin to murine control macrophages...
  19. Thurner L, Hartmann S, Fadle N, Kemele M, Bock T, Bewarder M, et al. LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting. Leukemia. 2018;: pubmed publisher
    ..reacted specifically with the autoantigen low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1)...
  20. Mrazek A, Porro L, Bhatia V, Falzon M, Spratt H, Zhou J, et al. Apigenin inhibits pancreatic stellate cell activity in pancreatitis. J Surg Res. 2015;196:8-16 pubmed publisher
    ..treatment (once daily, 50 μg per mouse by oral gavage) was initiated 1 wk into the recurrent acute pancreatitis (RAP) protocol. Pancreata were harvested after 4 wk of RAP...
  21. Clancy R, Markham A, Jackson T, Rasmussen S, Blumenberg M, Buyon J. Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block. Am J Physiol Heart Circ Physiol. 2017;313:H631-H640 pubmed publisher
    ..PDE)4D, chemokine (C-X-C motif) ligand (CXCL)2, and CXCL3 were upregulated, while others, including adenomedullin, RAP guanine nucleotide exchange factor 3 (RAPGEF3), tissue inhibitor of metalloproteinase (TIMP)1, TIMP3, and dual ..
  22. Yao L, Zhao H, Tang H, Liang J, Liu L, Dong H, et al. The receptor for advanced glycation end products is required for ?-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016;173:2600-13 pubmed publisher
    ..Inhibitors of RAGE, FPS-ZM1 and the RAGE antagonist peptide (RAP), were injected i.p. after each challenge...
  23. Becerra E, Morescalchi F, Gandolfo F, Danzi P, Nascimbeni G, Arcidiacono B, et al. Clinical evidence of intravitreal triamcinolone acetonide in the management of age-related macular degeneration. Curr Drug Targets. 2011;12:149-72 pubmed
    ..for the treatment of all types of CNV: classic or predominantly classic, occult or minimally classic and RAP (Retinal Angiomatous Proliferation) lesions...
  24. Hashim Y, Shepherd D, Wiltshire S, Holman R, Levy J, Clark A, et al. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Diabetologia. 2001;44:2227-30 pubmed
    ..The absence of diabetes-specific associations with alpha2M, ApoE or ApoE promoter variants suggest that these are not important in the onset of hyperglycaemia. ..
  25. Yang T, Terman J. Characterizing PKA-Mediated Phosphorylation of Plexin Using Purified Proteins. Methods Mol Biol. 2017;1493:147-159 pubmed
    ..of the plexin GTPase-activating protein (GAP) domain, which in turn inhibits endogenous GAP activity toward Ras/Rap family small GTP-binding proteins by recruiting the phospho-serine/threonine-binding protein 14-3-3ε...
  26. Segura Ibarra V, Amione Guerra J, Cruz Solbes A, Cara F, Iruegas Nunez D, Wu S, et al. Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension. Int J Pharm. 2017;524:257-267 pubmed publisher
    ..We hypothesized that rapamycin (RAP)-loaded NPs, an mTOR inhibitor, would accumulate in diseased lungs, selectively targeting vascular mTOR and ..
  27. Saito M, Iida T, Kano M, Itagaki K. Two-year results of combined intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation. Jpn J Ophthalmol. 2016;60:42-50 pubmed
    ..IVR) injections and photodynamic therapy (PDT) in patients with symptomatic retinal angiomatous proliferation (RAP) over 24 months...
  28. Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016;90:230-42 pubmed publisher
    ..the autophagy inhibitor 3-methyladenine (3-MA) also can inhibit apoptosis, while autophagy activator rapamycin (RAP) has the opposite effect, and the apoptosis inhibitor ZVAD-fmk also inhibited autophagy induced by momordin Ic...
  29. Jelonek K, Li S, Kaczmarczyk B, Marcinkowski A, Orchel A, Musiał Kulik M, et al. Multidrug PLA-PEG filomicelles for concurrent delivery of anticancer drugs-The influence of drug-drug and drug-polymer interactions on drug loading and release properties. Int J Pharm. 2016;510:365-74 pubmed publisher
    ..Three hydrophobic drugs-paclitaxel (Ptx), 17-AAG and rapamycin (Rap) were incorporated in poly(l-lactide)-poly(ethylene glycol) (PLA-PEG) filomicelles...
  30. Maaß J, Sandner D, Matthé E. [Intravitreal ranibizumab for the treatment of retinal angiomatous proliferation]. Ophthalmologe. 2017;114:534-542 pubmed publisher
    Retinal angiomatous proliferations (RAP) are a subgroup of exsudative or "wet" age-related macular degeneration (wAMD) with devastating reduction of visual acuity in later stages...
  31. Eloy J, Petrilli R, Chesca D, Saggioro F, Lee R, Marchetti J. Anti-HER2 immunoliposomes for co-delivery of paclitaxel and rapamycin for breast cancer therapy. Eur J Pharm Biopharm. 2017;115:159-167 pubmed publisher
    ..Rapamycin (RAP), an mTOR inhibitor, acts synergistically with PTX, and thus could be used in combination with it...
  32. Botta R, Lisi S, Rotondo Dottore G, Vitti P, Marino M. Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin. J Endocrinol Invest. 2017;40:991-997 pubmed publisher
    ..Because both sortilin and Tg bind to the low-density lipoprotein receptor-associated protein (RAP), we investigated whether RAP serves such a function...
  33. Tolone C, Pellino V, Piccirillo M, Letizia M, Belfiore I, Tolone S. Recurrent abdominal pain in children: underlying pathologies in the absence of "alarm" symptoms. Minerva Pediatr. 2017;69:239-244 pubmed publisher
    Recurrent abdominal pain (RAP) is a common disorder in childhood. However, it is not clear what the incidence of organic disease is, in the absence of "alarm" symptoms or signs...
  34. Guo X, An S, Yang Y, Liu Y, Hao Q, Xu T. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra. Cell Physiol Biochem. 2016;39:137-56 pubmed publisher
    b>Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways...
  35. Cheng M, Li J, Wu T, Tian W. Short-Term Effects and Safety Analysis of Retrograde Autologous Blood Priming for Cardiopulmonary Bypass in Patients with Cardiac Valve Replacement Surgery. Cell Biochem Biophys. 2015;73:441-446 pubmed publisher
    ..double-blind study evaluated the short-term effects and safety of perioperative retrograde autologous priming (RAP) for cardiopulmonary bypass (CPB) in patients with cardiac replacement surgery to determine if this approach is a ..
  36. Oono Y, Yazawa T, Kanamori H, Sasaki H, Mori S, Matsumoto T. Genome-wide analysis of rice cis-natural antisense transcription under cadmium exposure using strand-specific RNA-Seq. BMC Genomics. 2017;18:761 pubmed publisher
    ..a class of endogenous coding or non-protein-coding RNAs with sequence complementarity to the opposite strands of RAP transcripts. Many RAP transcripts possessed cis-NATs and these cis-NATs were responsive to some extent...
  37. Bu G, Rennke S, Geuze H. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). J Cell Sci. 1997;110 ( Pt 1):65-73 pubmed
    The 39 kDa receptor-associated protein (RAP) is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family...
  38. Foca C, Moses E, Quinn M, Rice G. Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma. Mol Hum Reprod. 2000;6:921-7 pubmed
    ..The role of LRP and its ligand binding inhibitor, the receptor-associated protein (RAP), in the advancement of invasive endometrial carcinoma is unknown...
  39. Wu Y, Migliorini M, Walsh J, Yu P, Strickland D, Wang Y. NMR structural studies of domain 1 of receptor-associated protein. J Biomol NMR. 2004;29:271-9 pubmed
    The 39 kDa receptor-associated protein (RAP) is an endoplasmic reticulum resident protein that binds tightly to the low-density lipoprotein receptor-related protein (LRP) as well as to other members of the low-density lipoprotein ..
  40. Santovito A, Burgarello C, Bulgarello C, Caravatti G, Ouattara M, Cervella P, et al. ACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population. Hum Biol. 2007;79:699-706 pubmed
    The ACE and the LRPAP1 gene insertion-deletion polymorphisms were determined in 133 healthy individuals sampled from Ouangolodougou, a village located in northern Ivory Coast...
  41. Köhler M, Emmelin M, Rosvall M. Parental health and psychosomatic symptoms in preschool children: A cross-sectional study in Scania, Sweden. Scand J Public Health. 2017;45:846-853 pubmed publisher
    The aim of the study was to assess the association between parental self-rated health and recurrent abdominal pain (RAP) in preschool children.
  42. Taira K, Bujo H, Hirayama S, Yamazaki H, Kanaki T, Takahashi K, et al. LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. Arterioscler Thromb Vasc Biol. 2001;21:1501-6 pubmed
    ..the human LR11, when overexpressed in hamster cells, binds and internalizes 39-kDa receptor-associated protein (RAP), an in vitro ligand for all receptors belonging to the LDLR family...
  43. Artz A, Butz S, Vestweber D. GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-?RII heterodimer. Blood. 2016;128:529-41 pubmed publisher
    ..GDF-15 and TGF-?1 interfered with integrin activation by inhibiting the activation of Ras-related protein 1 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell division control ..
  44. Lu G, Xu C, Tang K, Zhang J, Li Q, Peng L, et al. H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation. Biochem Biophys Res Commun. 2017;483:534-540 pubmed publisher
    ..In our beagle AF model, 24 h of rapid atrial pacing (RAP) increased the atrial Ang II concentration, ROS production and the protein expression of Nox4, Kv1...
  45. Dieho K, Bannink A, Geurts I, Schonewille J, Gort G, Dijkstra J. Morphological adaptation of rumen papillae during the dry period and early lactation as affected by rate of increase of concentrate allowance. J Dairy Sci. 2016;99:2339-2352 pubmed publisher
    ..9 kg of DM/d concentrate). Treatment consisted of either a rapid (1.0 kg of DM/d; RAP; n=6) or gradual (0.25 kg of DM/d; GRAD; n=6) increase of concentrate allowance (up to 10...
  46. Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, et al. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 2016;212:449-63 pubmed publisher
    ..number, (b) modulate synaptic plasticity, and (c) exert these effects via its interaction with spine-associated Rap guanosine triphosphatase-activating protein and subsequent activation of LIM-domain protein kinase 1/cofilin-..
  47. Dou Y, Chen Y, Zhang X, Xu X, Chen Y, Guo J, et al. Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis. Biomaterials. 2017;143:93-108 pubmed publisher
    ..Using an anti-atherosclerotic drug rapamycin (RAP), we found stimuli-responsive release of therapeutic molecules from Ac-bCD and Ox-bCD nanotherapies...
  48. Vercoulen Y, Kondo Y, Iwig J, Janssen A, White K, Amini M, et al. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. elife. 2017;6: pubmed publisher
    RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease...
  49. To J, Smrcka A. Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration. J Biol Chem. 2018;293:1570-1578 pubmed publisher
    ..Cell migration involves cycles of adhesion and de-adhesion, and we propose that the dynamic spatiotemporal balance between Gβγ-promoted adhesion and Gαi-GTP reversal of adhesion is important for this process. ..
  50. McGarvey T, Hussain M, Stearns M. In situ hybridization studies of alpha 2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma. Prostate. 1996;28:311-7 pubmed
    ..to examine the expression of both alpha 2-macroglobulin (alpha 2-MR) and the 39 kDa receptor-associated protein (RAP) in 8 benign (BPH) and 34 malignant human prostate tissues, including 4 metastases...
  51. Prasad G, Rao J, Fatima H, Shareef H, Shah A, Satyanarayana G. Malrotation of midgut in adults, an unsuspected and neglected condition--An analysis of 64 consensus confirmed cases. Indian J Gastroenterol. 2015;34:426-30 pubmed publisher
    ..This study evaluated malrotation in adults with recurrent abdominal pain (RAP). Sixty-four consensus-confirmed cases of intestinal malrotation were reviewed...
  52. Liu Y, Lacal J, Veltman D, Fusetti F, Van Haastert P, Firtel R, et al. A G?-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis. Dev Cell. 2016;37:458-72 pubmed publisher
    ..edge and functions as a G?-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance Ras and Rap signaling. The kinetics of GflB translocation are fine-tuned by GSK-3 phosphorylation...
  53. Flück C. MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction. Eur J Endocrinol. 2017;177:R99-R111 pubmed publisher
    ..deficiency (FGD), in which no mutations in the genes for the ACTH receptor (MC2R) or its accessory protein MRAP have been found, non-classic steroidogenic acute regulatory protein (StAR) and CYP11A1 mutations have ..
  54. Talagas A, Fontaine L, Ledesma García L, Mignolet J, Li de la Sierra Gallay I, Lazar N, et al. Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS. PLoS Pathog. 2016;12:e1005980 pubmed publisher
    ..The latter comprise the RNPP family (Rgg and original regulators Rap, NprR, PrgX and PlcR), whose members regulate important bacterial processes such as sporulation, conjugation, and ..
  55. Wan Y, Zhuo N, Li Y, Zhao W, Jiang D. Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae. Biochem Biophys Res Commun. 2017;488:46-52 pubmed publisher
    ..Furthermore, rapymycin (RAP) significantly improved osteogenic differentiation through autophagy activatoin...
  56. Peng Li -, Lei Yu -, Yang Li -, Karmakar C, Changchun Liu -. Increased beat-to-beat variation in diastolic phase percentages in patients with congestive heart failure. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:1328-1331 pubmed publisher
    ..Radial artery pressure (RAP) was monitored in synchrony with electrocardiography (ECG) for 5 min in order to extract the proposed DPV...
  57. Martins A, Farinha C, Raimundo M, Lopes M, Santos A, Melo P, et al. Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation. Ophthalmic Res. 2018;59:88-97 pubmed publisher
    ..early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes...
  58. Kochav S, Flores R, Truby L, Topkara V. Prognostic Impact of Pulmonary Artery Pulsatility Index (PAPi) in Patients With Advanced Heart Failure: Insights From the ESCAPE Trial. J Card Fail. 2018;24:453-459 pubmed publisher
    ..indices of RV function including RV stroke work index and right atrial/pulmonary capillary wedge pressure ratio (RAP/PCWP) in the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial...
  59. Mantel I, Ambresin A, Zografos L. Retinal angiomatous proliferation treated with a combination of intravitreal triamcinolone acetonide and photodynamic therapy with verteporfin. Eur J Ophthalmol. 2006;16:705-10 pubmed
    Retinal angiomatous proliferation (RAP) is a particularly aggressive form of exudative age-related macular degeneration. Response to laser photocoagulation or to photodynamic therapy (PDT) alone is often disappointing...
  60. Olsson K, Frank A, Fuge J, Welte T, Hoeper M, Bitter T. Acute hemodynamic effects of adaptive servoventilation in patients with pre-capillary and post-capillary pulmonary hypertension. Respir Res. 2015;16:137 pubmed publisher
    ..Hemodynamic variables included heart rate, blood pressure, right atrial pressure (RAP), mean pulmonary artery pressure (PAPm), pulmonary arterial wedge pressure (PAWP), cardiac output and pulmonary ..
  61. Kopperud R, Rygh C, Karlsen T, Krakstad C, Kleppe R, Hoivik E, et al. Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf). 2017;219:441-452 pubmed publisher
    ..This study probes the role of the cAMP mediators rap guanine nucleotide exchange factor 3 and 4 (Epac1 and Epac2) for in vivo control of microvascular macromolecule ..
  62. De Nardis C, Lössl P, van den Biggelaar M, Madoori P, Leloup N, Mertens K, et al. Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). J Biol Chem. 2017;292:912-924 pubmed publisher
    ..We investigated the binding properties of LRP1 using receptor-associated protein (RAP) as a model ligand due to its tight binding interaction...
  63. Ihle C, Weiß C, Blumenstock G, Stöckle U, Ochs B, Bahrs C, et al. Interview based malnutrition assessment can predict adverse events within 6 months after primary and revision arthroplasty - a prospective observational study of 351 patients. BMC Musculoskelet Disord. 2018;19:83 pubmed publisher
    ..This study aims to identify the risk for malnutrition following primary (pAP) and revision arthroplasty (rAP) (1) using non-invasive interview based assessment tools and to analyze effects on clinical outcome (2) and quality ..
  64. Stravodimos K, Katafigiotis I, Fragkiadis E, Tyritzis S, Constantinides C. Correcting and sharing our complications. Misplacement of pigtail catheter, during a Robot Assisted Pyeloplasty. Clinical findings, diagnosis, possible causes and endoscopic treatment. Arch Ital Urol Androl. 2015;87:165-6 pubmed publisher
    Robotic assisted pyeloplasty (RAP) is rapidly adopted by surgeons around the world. We present a unique complication of the technique, consisting of pigtail misplacement, which was endoscopically resolved...
  65. Zhang C, Lu J, Liu B, Cui Q, Wang Y. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016;8:272-90 pubmed
    ..Additionally, the rs11014002 SNP promotes the biogenesis of mature miR-603. miR-603 downregulates LRPAP1 mRNA and protein levels through directly binding the 3' untranslated region (3'UTR) of LRPAP1...
  66. Baek J, Lee J, Kim J, Kim N, Lee W. Geographic Atrophy and Activity of Neovascularization in Retinal Angiomatous Proliferation. Invest Ophthalmol Vis Sci. 2016;57:1500-5 pubmed publisher
    ..the association between geographic atrophy (GA) and neovascular activity in retinal angiomatous proliferation (RAP) during anti-VEGF treatment...
  67. Shi Z, Ye Y, Wu Y. Rank-based pooling for deep convolutional neural networks. Neural Netw. 2016;83:21-31 pubmed publisher
    ..This pooling mechanism can also be realized as rank-based average pooling (RAP), rank-based weighted pooling (RWP) and rank-based stochastic pooling (RSP) according to different weighting ..
  68. Grunwald J, Pistilli M, Daniel E, Ying G, Pan W, Jaffe G, et al. Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology. 2017;124:97-104 pubmed publisher
    ..worse visual acuity, larger choroidal neovascularization (CNV) area, retinal angiomatous proliferation (RAP) lesion, GA in the fellow eye, and intraretinal fluid were associated with a higher risk of incident GA...
  69. Nielsen P, Ellgaard L, Etzerodt M, Thogersen H, Poulsen F. The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein. Proc Natl Acad Sci U S A. 1997;94:7521-5 pubmed
    ..structure of the N-terminal domain (residues 18-112) of alpha2-macroglobulin receptor-associated protein (RAP) has been determined by NMR spectroscopy...
  70. Shariati B, Thompson E, Nicol G, Vasko M. Epac activation sensitizes rat sensory neurons through activation of Ras. Mol Cell Neurosci. 2016;70:54-67 pubmed publisher
    ..enhancement of AP generation or CGRP release, despite the fact that in most other cell types, Epacs act as Rap-GEFs...
  71. Sakurada Y, Yoneyama S, Sugiyama A, Tanabe N, Kikushima W, Mabuchi F, et al. Prevalence and Genetic Characteristics of Geographic Atrophy among Elderly Japanese with Age-Related Macular Degeneration. PLoS ONE. 2016;11:e0149978 pubmed publisher
    ..into typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP) or geographic atrophy (GA)...
  72. Shu C, Huang W, Zeng Z, He Y, Luo B, Liu H, et al. Connexin 43 is involved in the sympathetic atrial fibrillation in canine and canine atrial myocytes. Anatol J Cardiol. 2017;18:3-9 pubmed publisher
    ..was induced in dogs and isolated canine atrial myocytes by isoproterenol (ISO) perfusion and rapid atrium pacing (RAP)...
  73. Jaramillo Ortiz J, Montenegro V, de la Fournière S, Sarmiento N, Farber M, Wilkowsky S. Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis. Vet Sci. 2018;5: pubmed publisher
    ..The multi-antigen comprises gene fragments of three previously characterized B. bovis antigens: MSA-2c, RAP-1 and the Heat Shock protein 20 that are well-conserved among geographically distant strains...
  74. Medved L, Migliorini M, Mikhailenko I, Barrientos L, Llinas M, Strickland D. Domain organization of the 39-kDa receptor-associated protein. J Biol Chem. 1999;274:717-27 pubmed
    The 39-kDa receptor-associated protein (RAP) is an endoplasmic reticulum resident protein that binds to the low density lipoprotein receptor-related protein (LRP) as well as certain members of the low density lipoprotein receptor ..
  75. Nielsen M, Jacobsen C, Olivecrona G, Gliemann J, Petersen C. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem. 1999;274:8832-6 pubmed
    Lipoprotein lipase and the receptor-associated protein (RAP) bind to overlapping sites on the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP)...
  76. Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed
    ..of apoER2 with Reelin and compared this interaction to that of apoER2 with the receptor-associated protein (RAP), an apoER2 ligand that does not induce signaling...
  77. Reche Frutos J, Calvo Gonzalez C, Pérez Trigo S, Fernandez Perez C, Donate Lopez J, Garcia Feijoo J. Ranibizumab in retinal angiomatous proliferation (RAP): influence of RAP stage on visual outcome. Eur J Ophthalmol. 2011;21:783-8 pubmed publisher
    To evaluate the influence of retinal angiomatous proliferation (RAP) stage on visual and anatomic outcome after ranibizumab (Lucentis®).
  78. Parravano M, Pilotto E, Musicco I, Varano M, Introini U, Staurenghi G, et al. Reproducibility of fluorescein and indocyanine green angiographic assessment for RAP diagnosis: a multicenter study. Eur J Ophthalmol. 2012;22:598-606 pubmed publisher
    To explore the interobserver agreement in the diagnosis of retinal angiomatous proliferation (RAP) using fluorescein (FA) and indocyanine green angiographies (ICGA) and to detect which morphologic features of the neovascular lesion are ..
  79. Shen X, Ma L, Dong W, Wu Q, Gao Y, Luo C, et al. Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway. Neurochem Int. 2016;96:100-12 pubmed publisher
    ..3-Methyladenine (3-MA) and rapamycin (RAP) were administrated both in vivo and in vitro...
  80. Cuellar J, Valpuesta J, Wittinghofer A, Sot B. Domain topology of human Rasal. Biol Chem. 2017;: pubmed publisher
    ..GAP1IP4BP and Capri, their remaining domains are responsible for converting the RasGAP domains into dual Ras- and Rap-GAPs, via an incompletely understood mechanism...
  81. Persky A, Hogg A. Influence of Reading Material Characteristics on Study Time for Pre-Class Quizzes in a Flipped Classroom. Am J Pharm Educ. 2017;81:103 pubmed publisher
    ..reading material relates to pre-class time spent preparing for the readiness assurance process (RAP) in a team-based learning (TBL) course. Methods...
  82. Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley K. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988;7:4119-27 pubmed
    ..We propose that this LDL-receptor related protein (LRP) is a recycling lipoprotein receptor with possible growth-modulating effects. ..
  83. Obermoeller L, Warshawsky I, Wardell M, Bu G. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone. J Biol Chem. 1997;272:10761-8 pubmed
    The 39-kDa receptor-associated protein (RAP) is a molecular chaperone for the low density lipoprotein receptor-related protein (LRP), a large endocytic receptor that binds multiple ligands...
  84. Hyams K, Barrett D, Duque D, Engel C, Friedl K, Gray G, et al. The Recruit assessment Program: a program to collect comprehensive baseline health data from U.S. military personnel. Mil Med. 2002;167:44-7 pubmed
    Pilot testing has begun on the Recruit Assessment Program (RAP)...
  85. Lou X, McQuistan T, Orlando R, Farquhar M. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J Am Soc Nephrol. 2002;13:918-27 pubmed
  86. Wang L, Rhodes C, Lawrence J. Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006;281:24293-303 pubmed
  87. Singh N, Banerjee B, Bala K, Mitrabasu -, Dung Dung A, Chhillar N. APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease. Neurol Sci. 2014;35:1075-81 pubmed publisher
    ..variation in two lipid metabolizing genes, low-density lipoprotein receptor-related protein-associated protein (LRPAP1) and apolipoprotein E (APOE) gene in Parkinson's disease (PD)...
  88. Cerutti C, Ridley A. Endothelial cell-cell adhesion and signaling. Exp Cell Res. 2017;358:31-38 pubmed publisher
    ..Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under ..
  89. Mehde A, Mehdi W, Yusof F, Raus R, Abidin Z, Ghazali H, et al. Determination of alpha-2-MRAP gene polymorphisms in nephrolithiasis patients. Int J Biol Macromol. 2017;105:1324-1327 pubmed publisher
    The intron 5 insertion/deletion polymorphism of Alpha-2-macroglobulin receptor-associated protein gene (Alpha-2-MRAP) has been implicated in numerous diseases...
  90. Williams M, Sugatani T, Agapova O, Fang Y, Gaut J, Faugere M, et al. The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease. Kidney Int. 2018;93:147-158 pubmed publisher
    ..kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using the ActRIIA ligand trap RAP-011 initiated in 75-day-old Alport mice...
  91. Wang L, Feng D, Liu Y, Li S, Jiang L, Long Z, et al. Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis. Am J Transl Res. 2017;9:4261-4270 pubmed
    ..rapamycin following SCIR, autophagy in the SCIR-3-MA group decreased significantly, while that in the SCIR-Rap group increased, compared with SCIR-DMSO controls group...
  92. Wilkening R, Capodagli G, Khataokar A, Tylor K, Neiditch M, Federle M. Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond. J Biol Chem. 2017;292:20544-20557 pubmed publisher
    b>Rap/Rgg/NprR/PlcR/PrgX (RRNPP) quorum-sensing systems use extracellular peptide pheromones that are detected by cytoplasmic receptors to regulate gene expression in firmicute bacteria...