Gene Symbol: LRP12
Description: LDL receptor related protein 12
Alias: ST7, low-density lipoprotein receptor-related protein 12, suppressor of tumorigenicity 7 protein
Species: human
Products:     LRP12

Top Publications

  1. Battle M, Maher V, McCormick J. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. Biochemistry. 2003;42:7270-82 pubmed
    ..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12.
  2. Dacal E, Saugar J, de Lucio A, Hernández de Mingo M, Robinson E, Köster P, et al. Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola. Parasit Vectors. 2018;11:67 pubmed publisher
    ..7%), ST2 (30.7%), ST3 (36.0%), ST5 (1.3%) and ST7 (1.3%), respectively...
  3. Ma H, Jin S, Ju W, Fu Y, Tu Y, Wang L, et al. Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2017;36:109 pubmed publisher
    ..These results suggest that stathmin acts as an oncogene and is transcriptionally regulated by mutant p53, but not by wild-type p53. Stathmin could be a potential anti-tumor therapeutic target in OSCC. ..
  4. Mohseni Ahooyi T, Shekarabi M, Torkzaban B, Langford T, Burdo T, Gordon J, et al. Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing. Sci Rep. 2018;8:16300 pubmed publisher
    ..1 (SOAT1/ACAT1), sortilin-related receptor L1 (SORL1) and low-density lipoprotein receptor-related protein 12 (LRP12)...
  5. Akil A, Zhang Q, Mumaw C, Raiker N, Yu J, Velez de Mendizabal N, et al. Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2015;21:1739-45 pubmed publisher
    ..These biomarkers may provide opportunities for preemptive intervention to minimize SOS incidence and/or severity. ..
  6. Zanzani S, Gazzonis A, Epis S, Manfredi M. Study of the gastrointestinal parasitic fauna of captive non-human primates (Macaca fascicularis). Parasitol Res. 2016;115:307-12 pubmed publisher
    ..63% of macaques by PCR. These cynomolgus monkeys were infected with many subtypes (ST1, ST2, ST3, ST5, and ST7), where the predominant Blastocystis sp. subtypes were ST2 (77.5%), followed by ST1 (63.5%)...
  7. Sauvala M, Laaksonen S, Laukkanen Ninios R, Jalava K, Stephan R, Fredriksson Ahomaa M. Microbial contamination of moose (Alces alces) and white-tailed deer (Odocoileus virginianus) carcasses harvested by hunters. Food Microbiol. 2019;78:82-88 pubmed publisher
    ..L. monocytogenes isolates of different sequence types (ST7, 18, 29, 37, 249, 412, 451 and 611) belonged to serotypes 1/2a (seven isolates) and 4b (three isolates)...
  8. Chang L, Frame D, Braun T, Gatza E, Hanauer D, Zhao S, et al. Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes. Biol Blood Marrow Transplant. 2014;20:1407-17 pubmed publisher
    ..This study suggests the need for a prospective approach of collecting clinical features combined with correlative laboratory analyses to better characterize ES. ..
  9. Dermota U, Mueller Premru M, Å vent Kučina N, Petrovič Å, Ribič H, Rupnik M, et al. Survey of community-associated-methicillin-Resistant Staphylococcus aureus in Slovenia: identification of community-associated and livestock-associated clones. Int J Med Microbiol. 2015;305:505-10 pubmed publisher
    ..The most prevalent sequence types were ST5 (26.4%), ST45 (25.2%), ST22 (10.6%), ST398 (9.9%), ST8 (5.9%), ST7 (4.6%), ST1 (3.9%), ST152/377 (3.3%), ST228 (2.6%) and ST2883 (1.3%)...

More Information

Publications102 found, 100 shown here

  1. Luciani M, Troncone L, Monte F. Current and future circulating biomarkers for cardiac amyloidosis. Acta Pharmacol Sin. 2018;39:1133-1141 pubmed publisher
    ..Nevertheless, we envision a future class of biomarkers targeted at upstream events capable of detecting folding defects, which will ultimately expand the therapeutic window. ..
  2. Savage A, Muletz Wolz C, Campbell Grant E, Fleischer R, Mulder K. Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations. Immunogenetics. 2019;71:335-346 pubmed publisher
    ..Specifically, MHC heterozygotes and supertype ST1/ST7 had significantly lower Ranavirus infection intensity compared to homozygotes and other supertypes...
  3. Yoshikawa H, Tokoro M, Nagamoto T, Arayama S, Asih P, Rozi I, et al. Molecular survey of Blastocystis sp. from humans and associated animals in an Indonesian community with poor hygiene. Parasitol Int. 2016;65:780-784 pubmed publisher
    ..STs 1-3 were found in resident children, while ST5, ST7, and ST4 were found in domestic pigs and chickens, and in wild rodents, respectively...
  4. Savic Radojevic A, Pljesa Ercegovac M, Matic M, Simic D, Radovanovic S, Simic T. Novel Biomarkers of Heart Failure. Adv Clin Chem. 2017;79:93-152 pubmed publisher
    ..Hence, the future of biomarker application in HF lies in the multimarker panel strategy, which would include specific combination of biomarkers that reflect different pathophysiological processes underlying HF. ..
  5. Brito Santos F, Barbosa G, Trilles L, Nishikawa M, Wanke B, Meyer W, et al. Environmental isolation of Cryptococcus gattii VGII from indoor dust from typical wooden houses in the deep Amazonas of the Rio Negro basin. PLoS ONE. 2015;10:e0115866 pubmed publisher
    ..MLST studies identified eight subtypes, VGIIb (ST7), VGIIa (ST20), (ST5) and 5 new subtypes unique to the region. For the first time in the state of Amazonas, C...
  6. Yan S, Tang Z, Chen K, Liu Y, Yu G, Chen Q, et al. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. J Exp Clin Cancer Res. 2018;37:214 pubmed publisher
    ..Overall, our study illuminates the role of MIR31HG as a miRNA sponge in HCC, and sheds new light on lncRNA-directed diagnostics and therapeutics in HCC. ..
  7. Villalobos G, Orozco Mosqueda G, Lopez Perez M, Lopez Escamilla E, Córdoba Aguilar A, Rangel Gamboa L, et al. Suitability of internal transcribed spacers (ITS) as markers for the population genetic structure of Blastocystis spp. Parasit Vectors. 2014;7:461 pubmed publisher
    ..Regarding the Blastocystis STs found, 51% were ST1, 23% ST2, 19% ST3 and 2% ST7. For ITS, a haplotype network tree and Bayesian inference revealed the presence of two novel variants of ST1, ..
  8. Fabrin S, Soares N, Regalo S, Verri E. The Effects of Acupuncture on Peripheral Facial Palsy Sequelae after 20 Years via Electromyography. J Acupunct Meridian Stud. 2015;8:245-8 pubmed publisher
    ..once per week for 20 weeks: using manual stimulation at acupoints Yintang, LR3, GB21, CV17, ST2, ST3, ST6, ST7, GB2, and SI19; and Tou-Kuang-Min and ST4 using electrical stimulation with a 4-Hz pulsed current...
  9. Oliveira Arbex A, David E, Guimarães S. Blastocystis genetic diversity among children of low-income daycare center in Southeastern Brazil. Infect Genet Evol. 2018;57:59-63 pubmed publisher
    ..Four subtypes were identified and the most common were ST1 (54.4%) and ST3 (33.3%), followed by ST2 (7.0%) and ST7 (5.3%). The intra-subtype analysis revealed a total of 10 different alleles previously reported...
  10. Poulsen C, Efunshile A, Nelson J, Stensvold C. Epidemiological Aspects of Blastocystis Colonization in Children in Ilero, Nigeria. Am J Trop Med Hyg. 2016;95:175-9 pubmed publisher
    ..were positive for ST1, while 42 and 33 children were colonized with ST2 and ST3, respectively; a single case of ST7 was observed...
  11. Liao F, Gu W, Yang Z, Mo Z, Fan L, Guo Y, et al. Molecular characteristics of Staphylococcus aureus isolates from food surveillance in southwest China. BMC Microbiol. 2018;18:91 pubmed publisher
    ..aureus. Among them, ST6-t701 (13.15%), ST7-t091 (12.75%), ST59-t437 (9.96%) and ST5-t002 (7.57%) were the prevalent genotypes...
  12. Chen W, Li L, Yang J. Emerging Roles of IL-33/ST2 Axis in Renal Diseases. Int J Mol Sci. 2017;18: pubmed publisher
    ..In this review, we discuss the pathological and tissue reparative roles of the IL-33/ST2 pathway in different types of renal diseases. ..
  13. Qiao Y, Ning X, Chen Q, Zhao R, Song W, Zheng Y, et al. Clinical and molecular characteristics of invasive community-acquired Staphylococcus aureus infections in Chinese children. BMC Infect Dis. 2014;14:582 pubmed publisher
    ..3%), ST25 (13/92, 14.1%), ST7 (13/92, 14.1%), ST2155 (12/92, 13%), and ST188 (9/92, 9.8%) for MSSA...
  14. Huang K, Song Y, Zhang Q, Zhang A, Jin M. Characterisation of a novel integrative and conjugative element ICESsD9 carrying erm(B) and tet(O) resistance determinants in Streptococcus suis, and the distribution of ICESsD9-like elements in clinical isolates. J Glob Antimicrob Resist. 2016;7:13-18 pubmed publisher
    ..Twelve isolates mainly belonging to sequence types ST1, ST7 and ST28 were confirmed to harbour ICESsD9-like elements...
  15. Gatza E, Braun T, Levine J, Ferrara J, Zhao S, Wang T, et al. Etanercept plus topical corticosteroids as initial therapy for grade one acute graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2014;20:1426-34 pubmed publisher
    ..This trial is registered with, number NCT00726375. ..
  16. Tsai S, Lin C, Shih T, Tseng R, Yu M, Lin Y, et al. The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma. Mol Carcinog. 2017;56:2035-2047 pubmed publisher
    ..Our findings suggest that the miR-200b-ZEB1 circuit is a master regulator of diverse stemness of HCC, which differentiates HCCs into those containing CD13+ /CD24+ CSCs from those containing EpCAM+ CSCs. ..
  17. Li S, Yang F, Wang M, Cao W, Yang Z. miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer. Int J Mol Med. 2017;40:1047-1056 pubmed publisher
    ..In short, miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level in HeLa and SiHa cells, and serves important roles in the malignancy of CC. ..
  18. Björnsdóttir E, Martins E, Erlendsdóttir H, Haraldsson G, Melo Cristino J, Kristinsson K, et al. Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975-2014. Clin Microbiol Infect. 2016;22:379.e9-379.e16 pubmed publisher
    ..Nine cases of invasive GBS disease were caused by ST7, of possible zoonotic origin. All isolates were susceptible to penicillin...
  19. Ghosh S, Loffredo C, Mitra P, Trnovec T, Palkovičová Murínová Ľ, Sovcikova E, et al. PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations. Environ Sci Pollut Res Int. 2018;25:16493-16507 pubmed publisher
    ..TP53, MYC, BCL2, and LRP12 differential gene expressions suggested strong relationships between potential future tumor promotion and PCB ..
  20. Yowang A, Tsaousis A, Chumphonsuk T, Thongsin N, Kullawong N, Popluechai S, et al. High diversity of Blastocystis subtypes isolated from asymptomatic adults living in Chiang Rai, Thailand. Infect Genet Evol. 2018;65:270-275 pubmed publisher
    ..that colonise humans were detected with subtype (ST) three being the most common (68%), followed by ST1 (17%) and ST7 (7%)...
  21. Ma D, Chang L, Zhao S, Zhao J, Xiong Y, Cao F, et al. KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression. Sci Rep. 2017;7:15683 pubmed publisher
    ..Our results demonstrate that KLF5 and TNFRSF11a promote cervical cancer cell proliferation, migration and invasiveness. ..
  22. Ciccone M, Cortese F, Gesualdo M, Riccardi R, Di Nunzio D, Moncelli M, et al. A novel cardiac bio-marker: ST2: a review. Molecules. 2013;18:15314-28 pubmed publisher
    ..The aim of this review is to explore the possible role of ST2 derived-protein as an early marker of cardiovascular diseases, above all in heart failure and ischemic heart diseases. ..
  23. Mohamed R, El Bali M, Mohamed A, Abdel Fatah M, El Malky M, Mowafy N, et al. Subtyping of Blastocystis sp. isolated from symptomatic and asymptomatic individuals in Makkah, Saudi Arabia. Parasit Vectors. 2017;10:174 pubmed publisher
    ..Subtype (ST3) was the most prevalent (80.5%), followed by ST1 (14.5%) and ST2 (5%). ST4, ST5, ST6 and ST7 were not detected in this study. ST3 infections were significantly predominant (P?<?0...
  24. Huang L, Chen Y, Lin Y, Tam P, Cheng Y, Shi Y, et al. Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population. Sci China Life Sci. 2019;62:153-164 pubmed publisher
    ..2, ETV1/DGKB), rs548030386 (7q31.2, ST7 near CAV1/CAV2), rs7047871 (9p24.2, GLIS3), and rs2472494 (9q31.1, ABCA1/SLC44A1)...
  25. Quah C, Mehta R, Shivji F, Hassan S, Chandrasenan J, Moran C, et al. The effect of surgical experience on the amount of radiation exposure from fluoroscopy during dynamic hip screw fixation. Ann R Coll Surg Engl. 2017;99:198-202 pubmed publisher
    ..When analysed separately by trainee group, the most junior registrars (ST3-ST4) and the most senior registrars (ST7-ST8) were found to use significantly higher radiation levels than consultants (p=0.037 and p<0.001 respectively)...
  26. Ghosh S, Mitra P, Loffredo C, Trnovec T, Murinova L, Sovcikova E, et al. Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: indicator of disease and disorder development in humans. Environ Res. 2015;138:202-16 pubmed publisher
    ..ARNT, CYP2D6, LEPR, LRP12, RRAD, TP53, with a small population validation sample (n=71)...
  27. Shome R, Krithiga N, Shankaranarayana P, Jegadesan S, Udayakumar S V, Shome B, et al. Genotyping of Indian antigenic, vaccine, and field Brucella spp. using multilocus sequence typing. J Infect Dev Ctries. 2016;10:237-44 pubmed publisher
    ..Similarly, B. melitensis 16M reference strain and one B. melitensis field isolate were grouped into ST7. Another B. melitensis field isolate belonged to ST8 (draft genome sequence from India), and only B...
  28. Liang Y, Li Q, Chen K, Ni W, Zhan Z, Ye F, et al. Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncol Rep. 2017;38:2229-2236 pubmed publisher
    ..Therefore, our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of HCC via inducing apoptosis. ..
  29. Mehraj V, Ponte R, Routy J. The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. EBioMedicine. 2016;9:37-44 pubmed publisher
    ..Except for seminal studies, only articles published between 2010 and 2016 were included. ..
  30. Huang H, Zheng J, Shen N, Wang G, Zhou G, Fang Y, et al. Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. Sci Rep. 2018;8:10050 pubmed publisher
    ..Genes such as PSMG3, LRP12 MIA-RAB4B, ETHE1, SFXN1, DAZAP1, RABEP2, and C9orf16 were significantly regulated in synovitis of OA...
  31. Ben Abda I, Maatoug N, Ben Romdhane R, Bouhelmi N, Zallegua N, Aoun K, et al. Prevalence and Subtype Identification of Blastocystis sp. in Healthy Individuals in the Tunis Area, Tunisia. Am J Trop Med Hyg. 2017;96:202-204 pubmed publisher
    ..Among all the positive samples, 61 Blastocystis isolates were subtyped using partial small subunit ribosomal RNA gene analysis. ST3 was the most abundant (51%) followed by ST1 (30%), ST2 (16%), and ST4 and ST7 (both 1.6%).
  32. Alsonosi A, Holý O, Forsythe S. Characterization of the pathogenicity of clinical Cronobacter malonaticus strains based on the tissue culture investigations. Antonie Van Leeuwenhoek. 2019;112:435-450 pubmed publisher
    ..malonaticus (including 1827 and 2018) were able to persist well in macrophages. However, ST7 strains 1827 and 2018 proved to be the most invasive strains among all used strains...
  33. Coskun A, Malatyali E, Ertabaklar H, Yasar M, Karaoglu A, Ertug S. Blastocystis in ulcerative colitis patients: Genetic diversity and analysis of laboratory findings. Asian Pac J Trop Med. 2016;9:916-919 pubmed publisher
    ..7%), followed by ST1, ST2 and ST7. Laboratory findings between Blastocystis infected and non-infected UC patients were not significantly different...
  34. Wain L, Vaez A, Jansen R, Joehanes R, van der Most P, Erzurumluoglu A, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;: pubmed publisher
    ..We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals ..
  35. Yason J, Tan K. Membrane Surface Features of Blastocystis Subtypes. Genes (Basel). 2018;9: pubmed publisher
    ..Apart from the surface coat, a plasma membrane-associated surface antigen has been described for Blastocystis ST7 and is associated with programmed cell death features of the parasite.
  36. D Alfonso R, Santoro M, Essi D, Monsia A, Kaboré Y, Glé C, et al. Blastocystis in Côte d'Ivoire: molecular identification and epidemiological data. Eur J Clin Microbiol Infect Dis. 2017;36:2243-2250 pubmed publisher
    ..Blastocystis STs 1-3 and ST7 were identified in eight humans and four chickens, respectively...
  37. Sanpool O, Laymanivong S, Thanchomnang T, Rodpai R, Sadaow L, Phosuk I, et al. Subtype identification of human Blastocystis spp. isolated from Lao People's Democratic Republic. Acta Trop. 2017;168:37-40 pubmed publisher
    ..and phylogenetic analysis confirmed the distribution of four Blastocystis STs: ST1 (64%), ST2 (8%), ST3 (24%) and ST7 (4%)...
  38. Yotsumoto F, Fukagawa S, Miyata K, Nam S, Katsuda T, Miyahara D, et al. HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of EGFRT790M. Anticancer Res. 2017;37:3825-3831 pubmed
    ..These results suggest that HB-EGF is a rational target for the treatment of lung cancer with EGFR mutation. ..
  39. McCarthy C, Januzzi J. Soluble ST2 in Heart Failure. Heart Fail Clin. 2018;14:41-48 pubmed publisher
    ..Measurement of soluble ST2 has utility for assessing heart failure severity and prognosis. In this review, we examine the role of soluble ST2 in both acute and chronic heart failure. ..
  40. Liu L, Feng Y, Long H, McNally A, Zong Z. Sequence Type 273 Carbapenem-Resistant Klebsiella pneumoniae Carrying blaNDM-1 and blaIMP-4. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..It has two carbapenemase genes, blaNDM-1 (carried by an ST7 IncN self-transmissible plasmid) and blaIMP-4 (located on a self-transmissible IncHI5 plasmid)...
  41. Dogan N, Aydin M, Tüzemen N, Dinleyici E, Oguz I, Dogruman Al F. Subtype distribution of Blastocystis spp. isolated from children in Eskisehir, Turkey. Parasitol Int. 2017;66:948-951 pubmed publisher
    ..9%) as; ST1+ST3 (n=3), ST1+ST2 (n=1) and ST2+ST3 (n=1). None of the samples had ST5, ST6 or ST7. No statistically significant difference was found between the symptomatic and asymptomatic groups in terms of the ..
  42. Alazami A, Patel N, Shamseldin H, Anazi S, Al Dosari M, Alzahrani F, et al. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Cell Rep. 2015;10:148-61 pubmed publisher
    ..with disease, of which 33 are here described (SPDL1, TUBA3E, INO80, NID1, TSEN15, DMBX1, CLHC1, C12orf4, WDR93, ST7, MATN4, SEC24D, PCDHB4, PTPN23, TAF6, TBCK, FAM177A1, KIAA1109, MTSS1L, XIRP1, KCTD3, CHAF1B, ARV1, ISCA2, PTRH2, ..
  43. Hou X, Xiao M, Wang H, Yu S, Zhang G, Zhao Y, et al. Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%)...
  44. Meijers W, van der Velde A, de Boer R. Biomarkers in heart failure with preserved ejection fraction. Neth Heart J. 2016;24:252-8 pubmed publisher
    ..Further, we will discuss several emerging biomarkers such as galectin-3 and suppression of tumorigenicity 2, and recently discovered ones such as growth differentiation factor-15 and syndecan-1. ..
  45. Weber R, Layer F, Fuchs S, Bender J, Fiedler S, Werner G, et al. Complete Genome Sequences of Two Methicillin-Sensitive Staphylococcus aureus Isolates Representing a Population Subset Highly Prevalent in Human Colonization. Genome Announc. 2016;4: pubmed publisher
    ..Belonging to sequence type 582 (ST582) and ST7, both isolates are representatives of clonal lineages often associated with asymptomatic colonization of humans.
  46. Thiebaut R, Hue S, Le Marec F, Lelievre J, Dupon M, Foucat E, et al. Serum suppression of tumorigenicity 2 level is an independent predictor of all-cause mortality in HIV-infected patients. AIDS. 2017;31:2355-2365 pubmed publisher
    ..To evaluate the predictive value of soluble suppression of tumorigenicity 2 (sST2), a decoy receptor of IL-33 involved in several inflammatory and immune diseases, for death in HIV infection...
  47. Wang C, Yang N, Liu M, Hsu K, Kuo L. Estimating systemic fibrosis by combining galectin-3 and ST2 provides powerful risk stratification value for patients after acute decompensated heart failure. Cardiol J. 2016;23:563-572 pubmed publisher
    ..Combination of biomarkers involving heterogeneous fibrosis pathways may identify patients with high systemic fibrosis, providing powerful risk stratification value. ..
  48. Pfetsch V, Sanin V, Jaensch A, Dallmeier D, Mons U, Brenner H, et al. Increased Plasma Concentrations of Soluble ST2 Independently Predict Mortality but not Cardiovascular Events in Stable Coronary Heart Disease Patients: 13-Year Follow-up of the KAROLA Study. Cardiovasc Drugs Ther. 2017;31:167-177 pubmed publisher
    ..13)) and short-term FU (HR 3.06 (95% CI 1.29-7.24)). Elevated levels of sST2 concentration in stable CHD patients may independently predict short- and long-term risk for fatal CVD events and total mortality but not non-fatal CVD events. ..
  49. Tseng C, Huibers M, van Kuik J, de Weger R, Vink A, de Jonge N. The Interleukin-33/ST2 Pathway Is Expressed in the Failing Human Heart and Associated with Pro-fibrotic Remodeling of the Myocardium. J Cardiovasc Transl Res. 2018;11:15-21 pubmed publisher
    ..Therefore, other pathophysiological processes such as inflammation might also substantially affect sST2 plasma levels. ..
  50. Wan T, Hung W, Tsai J, Lin Y, Lee H, Hsueh P, et al. Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus. Antimicrob Agents Chemother. 2016;60:6108-14 pubmed publisher
    ..aureus (MRSA). The remaining 8 ermB-carrying isolates, belonging to ST7 (n = 4), ST5 (n = 3), and ST59 (n = 1), were sasK intact and did not carry MES-like structures...
  51. Aimo A, Vergaro G, Passino C, Ripoli A, Ky B, Miller W, et al. Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure: A Meta-Analysis. JACC Heart Fail. 2017;5:280-286 pubmed publisher
    ..sST2 is a predictor of both all-cause and CV death in CHF outpatients. The present meta-analysis supports the use of sST2 for risk stratification in patients with stable CHF. ..
  52. Yang H, Hur M, Kim H, Magrini L, Marino R, Di Somma S. Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis. Ann Lab Med. 2016;36:590-4 pubmed publisher
    ..2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis. ..
  53. Yucel O, Gul I, Zararsiz A, Demirpence O, Yucel H, Cinar Z, et al. Association of soluble ST2 with functional capacity in outpatients with heart failure. Herz. 2018;43:455-460 pubmed publisher
    ..810, 95% CI: 0.728- 0.875). Higher sST2 levels were strongly associated with poor NYHA functional class, independent of cardiac risk factors, in outpatients with HFrEF. ..
  54. Nomura S, Ishii K, Fujita S, Nakaya A, Satake A, Ito T. Associations between acute GVHD-related biomarkers and endothelial cell activation after allogeneic hematopoietic stem cell transplantation. Transpl Immunol. 2017;43-44:27-32 pubmed publisher
    ..Our findings suggest that endothelial cell activation might be linked to aGVHD, and that rTM might act to prevent aGVHD, at least in part, through its effect on endothelial cells. ..
  55. Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, et al. IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. PLoS Med. 2017;14:e1002365 pubmed publisher
    ..This IL33-ILC2-IL5-neutrophil axis defines a novel regulatory role for ILC2 in acute lung injury that could be targeted in trauma patients prone to early lung dysfunction. ..
  56. Matta B, Reichenbach D, Zhang X, Mathews L, Koehn B, Dwyer G, et al. Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39 pubmed publisher
  57. Marino R, Magrini L, Orsini F, Russo V, Cardelli P, Salerno G, et al. Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting Short-Term Mortality for Patients Presenting to the Emergency Department With Chest Pain. Ann Lab Med. 2017;37:137-146 pubmed publisher
    ..In STEMI patients, an sST2 value >35 ng/mL at ED arrival showed the highest predictive power for short-term mortality. ..
  58. Arslan Okuyucu K, Jeve Y, Doshani A. Work-related musculoskeletal injuries amongst obstetrics and gynaecology trainees in East Midland region of the UK. Arch Gynecol Obstet. 2017;296:489-494 pubmed publisher
    ..The response rate for the survey was 76% (59/78). The majority (22%) were senior specialist trainee, seventh year (ST7) and between 30 and 34 age groups...
  59. Moliner P, Lupón J, Barallat J, de Antonio M, Domingo M, Nunez J, et al. Bio-profiling and bio-prognostication of chronic heart failure with mid-range ejection fraction. Int J Cardiol. 2018;257:188-192 pubmed publisher
    ..Biomarkers commonly used for HFrEF risk prediction are more valuable for HFmrEF risk stratification. ..
  60. Hur M, Kim H, Kim H, Yang H, Magrini L, Marino R, et al. Soluble ST2 has a prognostic role in patients with suspected sepsis. Ann Lab Med. 2015;35:570-7 pubmed publisher
    ..0028). sST2 seems to be related to both cardiac dysfunction/failure and severity in sepsis. Measurement of sST2 and PCT in combination would be useful for risk stratification and prognosis prediction in patients with suspected sepsis. ..
  61. Forsell J, Granlund M, Samuelsson L, Koskiniemi S, Edebro H, Evengard B. High occurrence of Blastocystis sp. subtypes 1-3 and Giardia intestinalis assemblage B among patients in Zanzibar, Tanzania. Parasit Vectors. 2016;9:370 pubmed publisher
    ..The Blastocystis subtype distribution was ST1 34.0 %, ST2 26.4 %, ST3 25.5 %, ST7 0.9 %, and 13.2 % were positive only by qPCR (non-typable). The Giardia genetic assemblages identified were A 6...
  62. Martínez Meléndez A, Morfin Otero R, Villarreal Treviño L, Camacho Ortiz A, González González G, Llaca Díaz J, et al. Molecular epidemiology of coagulase-negative bloodstream isolates: detection of Staphylococcus epidermidis ST2, ST7 and linezolid-resistant ST23. Braz J Infect Dis. 2016;20:419-28 pubmed publisher
    ..All linezolid-resistant S. epidermidis isolates belonged to ST23; isolate with SCCmec type IV belonged to ST7, and isolate with SCCmec type III belonged to ST2. This is the first report of ST7 in Mexico...
  63. Boulogne M, Sadoune M, Launay J, Baudet M, Cohen Solal A, Logeart D. Inflammation versus mechanical stretch biomarkers over time in acutely decompensated heart failure with reduced ejection fraction. Int J Cardiol. 2017;226:53-59 pubmed publisher
    ..33 [95CI 1.13-4.80] and 2.42 [1.27-4.60]). AHF is associated with systemic inflammation. This inflammatory response continued up to one month after discharge despite normalisation of mechanical stress-related markers. ..
  64. Bonyadi Rad E, Musumeci G, Pichler K, Heidary M, Szychlinska M, Castrogiovanni P, et al. Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes. Sci Rep. 2017;7:17947 pubmed publisher
    ..Runx3 was, furthermore, identified as a novel Runx2 target in chondrocytes. This study suggests that Runx2 mediates ST2 and Runx3 induction to cooperatively regulate hypertrophic differentiation of ATDC5 chondrocytes. ..
  65. Liu H, Lv J, Qi X, Ding Y, Li D, Hu L, et al. The carriage of the serine-aspartate repeat protein-encoding sdr genes among Staphylococcus aureus lineages. Braz J Infect Dis. 2015;19:498-502 pubmed publisher
    ..05). All ST1, ST5, ST7, and ST25 isolates were positive for sdrD. While all ST121 and ST398 isolates were negative for sdrD...
  66. Wang Y, Li F, Wang D, Zhang P, Tao Y, Wang L, et al. [Study of molecular characteristics of methicillin-resistant Staphylococcus aureus in Maanshan area]. Zhonghua Liu Xing Bing Xue Za Zhi. 2015;36:285-9 pubmed
    ..1%, 16/34), ST5 (17.6%, 6/34). Three MSSA strains belonged to ST188, ST1281 and ST7, respectively. Seventeen strains from the patients were divided into 6 STs, ranging in sequence ST239 (35...
  67. Yu J, Storer B, Kushekhar K, Abu Zaid M, Zhang Q, Gafken P, et al. Biomarker Panel for Chronic Graft-Versus-Host Disease. J Clin Oncol. 2016;34:2583-90 pubmed publisher
    ..67 and 0.79 without and with known clinical risk factors, respectively. We conclude that the biomarker panel measured at diagnosis or day +100 after HCT may allow patient stratification according to risk of cGVHD. ..
  68. Meijers W, van der Velde A, Muller Kobold A, Dijck Brouwer J, Wu A, Jaffe A, et al. Variability of biomarkers in patients with chronic heart failure and healthy controls. Eur J Heart Fail. 2017;19:357-365 pubmed publisher
    ..NT-proBNP and GDF-15 have substantial variation, with lower variation for ST2, hsTnT, and galectin-3. These data are instrumental in proper interpretation of biomarker levels in HF patients. ..
  69. Zhang Z, Shen B, Cao X, Liu Z, Chen X, Nie Y, et al. Increased Soluble Suppression of Tumorigenicity 2 Level Predicts All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Prospective Cohort Study. Blood Purif. 2017;43:37-45 pubmed publisher
    ..Elevated sST2 is an independent predictor of all-cause and cardiovascular mortality in MHD patients. A combined use of sST2 and NT-proBNP or hs-cTnT helps identify individuals of higher risk. ..
  70. Johnpulle R, Paczesny S, Jung D, Daguindau E, Jagasia M, Savani B, et al. Metabolic Complications Precede Alloreactivity and Are Characterized by Changes in Suppression of Tumorigenicity 2 Signaling. Biol Blood Marrow Transplant. 2017;23:529-532 pubmed publisher
    ..sST2 was elevated in PTDM, indicating a relationship between glucose homeostasis and the IL-33/ST2 axis after transplantation. Correction of metabolic complications may decrease sST2 and improve NRM. ..
  71. Li T, Lu H, Wang X, Gao Q, Dai Y, Shang J, et al. Molecular Characteristics of Staphylococcus aureus Causing Bovine Mastitis between 2014 and 2015. Front Cell Infect Microbiol. 2017;7:127 pubmed publisher
    ..were determined by multi-locus sequence typing, while the dominant ST was ST97, followed by ST520, ST188, ST398, ST7, and ST9. Within 14 methicillin-resistant S. aureus (MRSA) isolates and 198 methicillin-susceptible S...
  72. Yason J, Ajjampur S, Tan K. Blastocystis Isolate B Exhibits Multiple Modes of Resistance against Antimicrobial Peptide LL-37. Infect Immun. 2016;84:2220-2232 pubmed publisher
    ..LL-37 causes membrane disruption and causes Blastocystis to change shape. Blastocystis subtype 7 (ST7), however, showed relative resistance to LL-37...
  73. Wang Y, Lo W, Lai R, Tse C, Lee R, Luk W, et al. IncN ST7 epidemic plasmid carrying blaIMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China. J Antimicrob Chemother. 2017;72:99-103 pubmed
    ..The blaIMP-4-carrying plasmids belonged to the IncN ST7 lineage (?50 kb). Twelve of the 16 plasmids were epidemiologically linked to seven different regions in China...
  74. Zotelli V, Grillo C, Gil M, Wada R, Sato J, da Luz Rosário de Sousa M. Acupuncture Effect on Pain, Mouth Opening Limitation and on the Energy Meridians in Patients with Temporomandibular Dysfunction: A Randomized Controlled Trial. J Acupunct Meridian Stud. 2017;10:351-359 pubmed publisher
    ..The acupoints used were: ST6, ST7, SI18, GV20, GB20, BL10, and LI4, during treatment performed for four weekly sessions...
  75. Gul I, Yucel O, Zararsiz A, Demirpence O, Yucel H, Zorlu A, et al. Prognostic role of soluble suppression of tumorigenicity-2 on cardiovascular mortality in outpatients with heart failure. Anatol J Cardiol. 2017;18:200-205 pubmed publisher
    ..sST2 measurement could help risk stratification in outpatients with HF. Moreover, this is the first study describing the impact of sST2 protein in Turkish patients with HF. ..
  76. García de Acilu M, Marin Corral J, Vázquez A, Ruano L, Magret M, Ferrer R, et al. Hypoxemic Patients With Bilateral Infiltrates Treated With High-Flow Nasal Cannula Present a Similar Pattern of Biomarkers of Inflammation and Injury to Acute Respiratory Distress Syndrome Patients. Crit Care Med. 2017;45:1845-1853 pubmed publisher
    ..The results suggest that these high-flow nasal cannula patients should be considered as acute respiratory distress syndrome patients. ..
  77. Gerber Y, Weston S, Enriquez Sarano M, Jaffe A, Manemann S, Jiang R, et al. Contemporary Risk Stratification After Myocardial Infarction in the Community: Performance of Scores and Incremental Value of Soluble Suppression of Tumorigenicity-2. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Incorporating comorbidities and soluble suppression of tumorigenicity-2 substantially improves risk prediction, thereby delineating opportunities to improve clinical care. ..
  78. Aldubyan M, Almami I, Benslimane F, Alsonosi A, Forsythe S. Comparative Outer Membrane Protein Analysis of High and Low-Invasive Strains of Cronobacter malonaticus. Front Microbiol. 2017;8:2268 pubmed publisher
    ..However, recently C. malonaticus, in particular sequence type 7 (ST7), has been noted as being prevalent in adult infections and therefore warranting further investigation...
  79. Schneider S, Gulacsi A, Hatten M. Lrp12/Mig13a reveals changing patterns of preplate neuronal polarity during corticogenesis that are absent in reeler mutant mice. Cereb Cortex. 2011;21:134-44 pubmed publisher
    ..b>Lrp12/Mig13a, a mammalian gene related to the Caenorhabditis elegans neuroblast migration gene mig-13, is expressed in a ..
  80. Seinige D, von Altrock A, Kehrenberg C. Genetic diversity and antibiotic susceptibility of Staphylococcus aureus isolates from wild boars. Comp Immunol Microbiol Infect Dis. 2017;54:7-12 pubmed publisher
    ..The S. aureus belonged to multilocus sequence types ST1, ST7, ST30, ST133, ST425, ST804, ST890 and to the new ST3237, ST3238, ST3255 and ST3369...
  81. Wang R, Li L, Huang Y, Huang T, Tang J, Xie T, et al. Pathogenicity of Human ST23 Streptococcus agalactiae to Fish and Genomic Comparison of Pathogenic and Non-pathogenic Isolates. Front Microbiol. 2017;8:1933 pubmed publisher
    ..rate caused by only three human isolates had statistically significant difference compared with fish-derived ST7 strain (P < 0...
  82. Debette S, Visvikis Siest S, Chen M, Ndiaye N, Song C, DESTEFANO A, et al. Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res. 2011;109:554-63 pubmed publisher
    ..Genetic variants explaining up to half the heritability of serum VEGF levels were identified. These new insights provide important clues to the pathways regulating circulating VEGF levels. ..
  83. Zhu Z, Chai Y, Jiang Y, Li W, Hu H, Li W, et al. Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Dev Cell. 2016;39:224-238 pubmed publisher
    ..The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions with ABL-1 or SEM-5/..
  84. Ogrodzki P, Forsythe S. DNA-Sequence Based Typing of the Cronobacter Genus Using MLST, CRISPR-cas Array and Capsular Profiling. Front Microbiol. 2017;8:1875 pubmed publisher
    ..sakazakii clonal complexes (CC) 1 and 4, sequence types (ST) 8 and 12 and C. malonaticus ST7. The capsular profile K2:CA2, previously proposed as being strongly associated with C. sakazakii and C...
  85. Jirak P, Fejzic D, Paar V, Wernly B, Pistulli R, Rohm I, et al. Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure. Acta Pharmacol Sin. 2018;39:1189-1196 pubmed publisher
    ..Further studies are necessary to validate the clinical applicability of these novel cardiovascular biomarkers. ..
  86. Garnis C, Coe B, Zhang L, Rosin M, Lam W. Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas. Oncogene. 2004;23:2582-6 pubmed
    ..analysis comparing 15 microdissected OSCC with 16 normal epithelium samples revealed overexpression specific to LRP12 but not the neighboring genes, dihydropyrimidinase and FOG2, suggesting that LRP12 may function as an oncogene in ..
  87. Grote A, Robens B, Blümcke I, Becker A, Schoch S, Gembé E. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Neurobiol Dis. 2016;86:170-6 pubmed publisher
    ..Lipoproteins and particularly low-density lipoprotein receptor-related protein 12 (LRP12) are involved in brain development. Here, we have examined a potential role of LRP12 in the pathogenesis of FCDs...
  88. Robens B, Gembé E, Fassunke J, Becker A, Schoch S, Grote A. Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas. Life Sci. 2016;155:70-5 pubmed publisher
    ..The pathogenesis of GGs is largely unknown. Low-density lipoprotein receptor-related protein 12 (LRP12) is critical for brain development and involved in tumorigenesis of non-cerebral neoplasms...
  89. Qing J, Wei D, Maher V, McCormick J. Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines. Oncogene. 1999;18:335-42 pubmed
    ..1 cells, we identified a novel gene, ST7, showing sixfold lower expression in 6A/SB1 cells compared with parental MSU-1.1 cells...
  90. Wiggs J, Yaspan B, Hauser M, Kang J, Allingham R, Olson L, et al. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012;8:e1002654 pubmed publisher
    ..009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma...
  91. Ragusa R, Cabiati M, Guzzardi M, D Amico A, Giannessi D, Del Ry S, et al. Effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver: study in the experimental model of Zucker rats. Exp Mol Pathol. 2017;102:354-359 pubmed publisher
    ..The strong relationships with NP systems and inflammatory mediators could suggest an involvement for IL-33/ST2 in molecular pathways leading to cardiac dysfunction and inflammation associated with obesity. ..
  92. Zhang Z, Liu X, Wang H, Qu Z, Crew R, Zhang N, et al. Increased soluble ST2 and IL?4 serum levels are associated with disease severity in patients with membranous nephropathy. Mol Med Rep. 2017;: pubmed publisher
    ..Following treatment, serum sST2 levels were considerably reduced, whereas serum IL?4 and IL?10 levels were significantly increased. These data suggest that sST2 and IL?4, but not IL?33, contribute to the pathogenesis of MN...