Gene Symbol: LR11
Description: sortilin related receptor 1
Alias: C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250, sortilin-related receptor, LDLR relative with 11 ligand-binding repeats, low-density lipoprotein receptor relative with 11 ligand-binding repeats, mosaic protein LR11, sortilin-related receptor, L(DLR class) A repeats containing, sorting protein-related receptor containing LDLR class A repeats
Species: human
Products:     LR11

Top Publications

  1. Minster R, DeKosky S, Kamboh M. No association of SORL1 SNPs with Alzheimer's disease. Neurosci Lett. 2008;440:190-2 pubmed publisher
    ..Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort. ..
  2. Jacobsen L, Madsen P, Moestrup S, Lund A, Tommerup N, Nykjaer A, et al. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem. 1996;271:31379-83 pubmed
    ..The receptor, designated sorLA-1, has a short cytoplasmic tail containing a tyrosine-based internalization signal and a large external part ..
  3. Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, et al. SORL1 is genetically associated with Alzheimer disease in a Japanese population. Neurosci Lett. 2009;461:177-80 pubmed publisher
    ..This risk was evident in non-carriers of the apolipoprotein E-epsilon 4 allele, but not in its carriers. Our results support the evidence that genetic variants of SORL1 affect susceptibility to late-onset AD. ..
  4. Kolsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel S, et al. Association of SORL1 gene variants with Alzheimer's disease. Brain Res. 2009;1264:1-6 pubmed publisher
    ..Thus, our data support a role of SORL1 polymorphisms in AD. ..
  5. Herskowitz J, Offe K, Deshpande A, Kahn R, Levey A, Lah J. GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-? production. Mol Biol Cell. 2012;23:2645-57 pubmed publisher
    ..Cell biological and genetic evidence has implicated the low-density lipoprotein and sorting receptor LR11/SorLA in AD through mechanisms related to APP and A? production...
  6. Rogaeva E, Meng Y, Lee J, Gu Y, Kawarai T, Zou F, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet. 2007;39:168-77 pubmed
    ..which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1...
  7. Smith E, Chen W, Kahonen M, Kettunen J, Lehtimaki T, Peltonen L, et al. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. PLoS Genet. 2010;6:e1001094 pubmed publisher
  8. Miyashita A, Koike A, Jun G, Wang L, Takahashi S, Matsubara E, et al. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS ONE. 2013;8:e58618 pubmed publisher
    ..Our study highlights the importance of examining associations in multiple ethnic populations. ..
  9. Ikeuchi T, Hirayama S, Miida T, Fukamachi I, Tokutake T, Ebinuma H, et al. Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease. Dement Geriatr Cogn Disord. 2010;30:28-32 pubmed publisher
    Recent genetic and pathological studies have suggested that a lipoprotein receptor, LR11, is intricately implicated in the pathogenesis of Alzheimer disease (AD)...

More Information


  1. Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, et al. Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 2012;31:187-200 pubmed publisher
    ..mathematical modelling to establish a kinetic model of amyloidogenic processing, and to evaluate the influence by SORLA/SORL1, an inhibitor of APP processing and important genetic risk factor...
  2. Liu F, Ikram M, Janssens A, Schuur M, de Koning I, Isaacs A, et al. A study of the SORL1 gene in Alzheimer's disease and cognitive function. J Alzheimers Dis. 2009;18:51-64 pubmed publisher
    ..In conclusion, our data do not support the hypothesis that genetic variants in SORL1 are related to the risk of AD. ..
  3. Cellini E, Tedde A, Bagnoli S, Pradella S, Piacentini S, Sorbi S, et al. Implication of sex and SORL1 variants in italian patients with Alzheimer disease. Arch Neurol. 2009;66:1260-6 pubmed publisher
    ..Further studies to detect pathogenic variants and further elucidate the effect of SORL1 on the development of AD are necessary. ..
  4. Fjorback A, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, et al. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012;32:1467-80 pubmed publisher
    b>sorLA is a sorting receptor for amyloid precursor protein (APP) genetically linked to Alzheimer's disease (AD)...
  5. Andersen O, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005;102:13461-6 pubmed
    b>sorLA (Sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons...
  6. Willnow T, Andersen O. Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. J Cell Sci. 2013;126:2751-60 pubmed publisher
    ..Here, we describe the functional elucidation of a new sorting receptor SORLA that emerges as a central regulator of trafficking and processing of APP...
  7. T Cuenco K, Lunetta K, Baldwin C, McKee A, Guo J, Cupples L, et al. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008;65:1640-8 pubmed publisher
  8. Tan E, Lee J, Chen C, Teo Y, Zhao Y, Lee W. SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese. Neurobiol Aging. 2009;30:1048-51 pubmed
    ..However, our study suggests that certain SORL1 haplotypes at SNPs 19-24 modulated risk of AD in our Chinese population. ..
  9. Nilsson S, Christensen S, Raarup M, Ryan R, Nielsen M, Olivecrona G. Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem. 2008;283:25920-7 pubmed publisher
    ..density lipoprotein receptor (LDL-R) gene family, known as the classical lipoprotein receptors, including LRP1 and SorLA/LR11. In addition to LDL-A binding repeats, the mosaic receptor SorLA/LR11 also possesses a Vps10p domain...
  10. Motoi Y, Aizawa T, Haga S, Nakamura S, Namba Y, Ikeda K. Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain. Brain Res. 1999;833:209-15 pubmed
    ..was recently discovered as a new member of the low density lipoprotein receptor (LDLR) family, designated as LR11. The predominant expression of LR11 transcripts in brain tissue and the presence of elements found in neural ..
  11. Bralten J, Arias Vasquez A, Makkinje R, Veltman J, Brunner H, Fernandez G, et al. Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults. Am J Psychiatry. 2011;168:1083-9 pubmed publisher
    ..The results support the hypothesis that the SORL1 gene contributes to an increased risk for Alzheimer's disease through effects on hippocampal volume. ..
  12. Nishii K, Nakaseko C, Jiang M, Shimizu N, Takeuchi M, Schneider W, et al. The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells. J Biol Chem. 2013;288:11877-86 pubmed publisher
    ..Here, we show that the soluble form (sLR11) of LR11 (also called SorLA or SORL1) modulates the uPAR-mediated attachment of HSPCs under hypoxic conditions...
  13. Kauwe J, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, et al. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. J Alzheimers Dis. 2010;21:833-42 pubmed publisher
    ..This association is consistent with previous reports that this non-synonymous coding substitution results in increased A? levels in vitro and provides support for an A?-related mechanism for modulating risk for Alzheimer's disease. ..
  14. Lee J, Chulikavit M, Pang D, Zigman W, Silverman W, Schupf N. Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome. Neurosci Lett. 2007;425:105-9 pubmed
    ..Thus, further studies are needed to identify functional variants that influence risk for AD in this uniquely vulnerable population. ..
  15. Alexopoulos P, Guo L, Kratzer M, Westerteicher C, Kurz A, Perneczky R. Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers. Dement Geriatr Cogn Disord. 2011;32:164-70 pubmed publisher
    ..Recently, genetic variants of the neuronal sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) have emerged as risk factors for the development of Alzheimer's disease (AD)...
  16. Jacobsen L, Madsen P, Nielsen M, Geraerts W, Gliemann J, Smit A, et al. The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett. 2002;511:155-8 pubmed
    We report that the Vps10p domain receptor sorLA binds the adaptor proteins GGA1 and -2, which take part in Golgi-endosome sorting...
  17. Li Y, Rowland C, Catanese J, Morris J, Lovestone S, O Donovan M, et al. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiol Dis. 2008;29:293-6 pubmed
    ..035); however, this result does not remain significant when accounting for multiple comparisons. Further validation in other sample sets will be required to assess the true effects of SORL1 variants in LOAD. ..
  18. Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, Andersen O, et al. SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem. 2007;282:32956-64 pubmed
    b>SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease...
  19. Grear K, Ling I, Simpson J, Furman J, Simmons C, Peterson S, et al. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener. 2009;4:46 pubmed publisher
    ..Overall, these results contribute to our understanding of SORL1 expression in the human brain. ..
  20. Lee J, Barral S, Reitz C. The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. Curr Neurol Neurosci Rep. 2008;8:384-91 pubmed
    ..However, putative variants have not yet been identified. Further research is necessary to determine its utility as a diagnostic marker of AD or as a target for new therapeutic approaches. ..
  21. Jacobsen L, Madsen P, Jacobsen C, Nielsen M, Gliemann J, Petersen C. Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem. 2001;276:22788-96 pubmed
    We previously isolated and sequenced the approximately 250-kDa type 1 receptor sorLA/LR11, a mosaic protein with elements characterizing the Vps10p domain receptor family as well as the low density lipoprotein receptor family...
  22. Herskowitz J, Seyfried N, Gearing M, Kahn R, Peng J, Levey A, et al. Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. J Biol Chem. 2011;286:6117-27 pubmed publisher
    LR11, also known as SorLA, is a mosaic low-density lipoprotein receptor that exerts multiple influences on Alzheimer disease susceptibility...
  23. Bettens K, Brouwers N, Engelborghs S, De Deyn P, Van Broeckhoven C, Sleegers K. SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. Hum Mutat. 2008;29:769-70 pubmed publisher
    ..Our findings confirm that genetic variants in SORL1 may be important risk factors for late-onset AD. ..
  24. Sager K, Wuu J, Leurgans S, Rees H, Gearing M, Mufson E, et al. Neuronal LR11/sorLA expression is reduced in mild cognitive impairment. Ann Neurol. 2007;62:640-7 pubmed
    LR11 (aka sorLA) is a multifunctional neuronal receptor that binds apolipoprotein E and interacts with amyloid precursor protein to regulate amyloidogenesis...
  25. Furuya T, da Silva P, Payão S, Rasmussen L, de Labio R, Bertolucci P, et al. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. Neurochem Int. 2012;61:973-5 pubmed publisher
    ..The impact of these studied genes on AD pathogenesis remains to be better clarified. ..
  26. Cramer J, Gustafsen C, Behrens M, Oliveira C, Pedersen J, Madsen P, et al. GGA autoinhibition revisited. Traffic. 2010;11:259-73 pubmed publisher
    ..or no influence and (iv) phosphorylation of GGA1 does not affect its conformation or binding to Sortilin and SorLA. Taken together, our findings seem to refute the functional significance of GGA autoinhibition in particular and ..
  27. Spoelgen R, von Arnim C, Thomas A, Peltan I, Koker M, Deng A, et al. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci. 2006;26:418-28 pubmed
    b>sorLA is a recently identified neuronal receptor for amyloid precursor protein (APP) that is known to interact with APP and affect its intracellular transport and processing...
  28. Meng Y, Lee J, Cheng R, St George Hyslop P, Mayeux R, Farrer L. Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport. 2007;18:1761-4 pubmed
    ..These results provide an independent replication of the association between AD and SORL1. ..
  29. Lee J, Cheng R, Honig L, Vonsattel J, Clark L, Mayeux R. Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. Neurology. 2008;70:887-9 pubmed
  30. Lee J, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, et al. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol. 2007;64:501-6 pubmed
    ..Broad regions of the SORL1 gene will therefore need to be scrutinized for functional pathogenic variants. ..
  31. Kolsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J, et al. Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett. 2008;440:68-71 pubmed publisher
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology. ..
  32. Scherzer C, Offe K, Gearing M, Rees H, Fang G, Heilman C, et al. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol. 2004;61:1200-5 pubmed
    ..We hypothesized that 1 of the genes, termed low-density lipoprotein receptor relative with 11 binding repeats (LR11) (reduced 1.8- and 2...
  33. Pottier C, Hannequin D, Coutant S, Rovelet Lecrux A, Wallon D, Rousseau S, et al. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. Mol Psychiatry. 2012;17:875-9 pubmed publisher
    ..SORL1 encodes the Sortilin-related receptor LR11/SorLA, a protein involved in the control of amyloid beta peptide production...
  34. Andersen O, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 2006;45:2618-28 pubmed
    b>SorLA/LR11 is a sorting receptor that regulates the intracellular transport and processing of the amyloid precursor protein (APP) in neurons...
  35. Klinger S, Glerup S, Raarup M, Mari M, Nyegaard M, Koster G, et al. SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. J Cell Sci. 2011;124:1095-105 pubmed publisher
    ..Here, we characterize the role of SorLA (officially known as SorLA-1 or sortilin-related receptor) in the intracellular trafficking of LPL...
  36. Reitz C, Cheng R, Rogaeva E, Lee J, Tokuhiro S, Zou F, et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol. 2011;68:99-106 pubmed publisher
    ..This comprehensive meta-analysis provides confirmatory evidence that multiple SORL1 variants in distinct linkage disequilibrium blocks are associated with AD. ..
  37. McCarthy J, Saith S, Linnertz C, Burke J, Hulette C, Welsh Bohmer K, et al. The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression. Neurobiol Aging. 2012;33:1485.e1-8 pubmed publisher
    ..Our results suggest that genetic regulation of SORL1 expression plays a role in disease risk and may be responsible for the reported LOAD associations. Further studies to detect the actual pathogenic variant/s are necessary. ..
  38. Olgiati P, Politis A, Albani D, Rodilossi S, Polito L, Ateri E, et al. Association of SORL1 alleles with late-onset Alzheimer's disease. findings from the GIGAS_LOAD study and mega-analysis. Curr Alzheimer Res. 2012;9:491-9 pubmed
    The pathophysiology of Alzheimer's disease (AD) is influenced by sorting-protein related receptor (sorLa) that is less expressed in AD patients...
  39. Xia J, Qi X, Wu Y, Zhu B, Xu L, Zhang L, et al. Genome-wide association study identifies loci and candidate genes for meat quality traits in Simmental beef cattle. Mamm Genome. 2016;27:246-55 pubmed publisher
    ..Our results offer valuable insights to further explore the potential mechanism of meat quality traits in Simmental beef cattle. ..
  40. Larsen J, Petersen C. SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017;37: pubmed publisher
    ..Here, we report that the endocytic receptor SorLA targets IL-6 and IL-6R...
  41. Ciarlo E, Massone S, Penna I, Nizzari M, Gigoni A, Dieci G, et al. An intronic ncRNA-dependent regulation of SORL1 expression affecting A? formation is upregulated in post-mortem Alzheimer's disease brain samples. Dis Model Mech. 2013;6:424-33 pubmed publisher
    ..Altogether, these findings document a novel ncRNA-dependent regulatory pathway that might have relevant implications in neurodegeneration. ..
  42. Nilsson S, Lookene A, Beckstead J, Gliemann J, Ryan R, Olivecrona G. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry. 2007;46:3896-904 pubmed
    ..lipoprotein receptor family, the low density lipoprotein receptor-related protein and the mosaic type-1 receptor, SorLA. Experiments using surface plasmon resonance showed specific binding of both free and lipid-bound apolipoprotein A-..
  43. Yin R, Li J, Tan L, Wang H, Tan M, Yu W, et al. Impact of SORL1 genetic variations on MRI markers in non-demented elders. Oncotarget. 2016;7:31689-98 pubmed publisher
    The sorting protein-related receptor 1 (SORL1 or LR11) gene has been verified to play an important role in the pathologic process of ?-amyloid (A?) formation and trafficking in Alzheimer's Disease (AD) by plenty of cytological and ..
  44. Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. Dement Geriatr Cogn Disord. 2008;26:161-4 pubmed publisher
    ..We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. ..
  45. Lee J, Freeman J. Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Metallomics. 2016;8:589-96 pubmed publisher
  46. Watanabe K, Suzuki H, Jiang M, Haniu H, Numano F, Hoshina S, et al. Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease. Atherosclerosis. 2016;246:94-7 pubmed publisher
    ..Intimal smooth muscle cells (SMCs) have an important role in vascular lesions in KD. It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions and LR11 is markedly expressed in intimal SMCs in atherosclerotic ..
  47. Verheijen J, Van den Bossche T, van der Zee J, Engelborghs S, Sanchez Valle R, Lladó A, et al. A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease. Acta Neuropathol. 2016;132:213-24 pubmed publisher
    ..Premature stop codons due to frameshift and nonsense variants, have so far exclusively been found in patients, and their predicted mode of action corresponds with evidence from in vitro functional studies of SORL1 in AD. ..
  48. Eggert S, Gonzalez A, Thomas C, Schilling S, Schwarz S, Tischer C, et al. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci. 2018;75:301-322 pubmed publisher
    ..via live cell imaging and biochemical analyses that APP dimerization affects its interaction with LRP1 and SorLA, suggesting that APP dimerization modulates its interplay with sorting molecules and in turn its localization and ..
  49. Nohara A, Kobayashi J, Kawashiri M, Tada H, Inazu A, Jiang M, et al. Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia. Clin Biochem. 2014;47:1326-8 pubmed publisher
    The LDL receptor relative with 11 ligand-binding repeats (LR11) is closely related to atherosclerotic disease or diabetes...
  50. Kim J, Castellano J, Jiang H, Basak J, Parsadanian M, Pham V, et al. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009;64:632-44 pubmed publisher
    ..Plaque-associated neuroinflammatory responses were attenuated in LDLR transgenic mice. These findings suggest that increasing LDLR levels may represent a novel AD treatment strategy. ..
  51. Mayeux R, Hyslop P. Alzheimer's disease: advances in trafficking. Lancet Neurol. 2008;7:2-3 pubmed
  52. Taira K, Bujo H, Hirayama S, Yamazaki H, Kanaki T, Takahashi K, et al. LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. Arterioscler Thromb Vasc Biol. 2001;21:1501-6 pubmed
    ..We have discovered that the expression of a 250-kDa mosaic LDLR-related protein, which we termed LR11 for the presence of 11 LDLR ligand-binding repeats, is markedly induced in smooth muscle cells in the hyperplastic ..
  53. Louwersheimer E, Ramirez A, Cruchaga C, Becker T, Kornhuber J, Peters O, et al. Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease. Neurobiol Aging. 2015;36:1605.e13-20 pubmed publisher
    ..In conclusion, we found that SORL1 SNP rs2070045-G allele was related to CSF-tau and hippocampal atrophy, 2 endophenotype markers of AD, suggesting that SORL1 may be implicated in the downstream pathology in AD. ..
  54. Larsen J, Kristensen A, Pallesen L, Bauer J, Vægter C, Nielsen M, et al. Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover. Mol Cell Biol. 2016;36:1272-86 pubmed publisher that CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRα and sorLA, is a key player in CLC and CNTFRα signaling and turnover...
  55. Shen J, Qin W, Xu Q, Xu L, Xu J, Zhang P, et al. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain Struct Funct. 2017;222:2877-2889 pubmed publisher
    ..The SORL1- and APOE-dependent hippocampal connectivity changes may at least partly account for their association with AD. ..
  56. Huang C, Liu M, Kao H, Chou K, Yang A, Wang Y, et al. Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan. Sci Rep. 2016;6:23362 pubmed publisher
    ..These findings provide evidence that SORL1 rs3824968 modulates regional GM volume and is associated with brain trajectory during the adult lifespan. ..
  57. Lintzel J, Franke I, Riedel I, Schaller H, Hampe W. Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA. Biol Chem. 2002;383:1727-33 pubmed
    The single transmembrane receptor sorLA/LR11 contains binding domains typical for the low-density lipoprotein receptors and a VPS10 domain which, in the related receptor sortilin, binds the neuropeptide neurotensin...
  58. Wang Z, Lei H, Zheng M, Li Y, Cui Y, Hao F. Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1. Mol Neurobiol. 2016;53:6501-6510 pubmed publisher
  59. Olgiati P, Politis A, Albani D, Rodilossi S, Polito L, Zisaki A, et al. Effects of SORL1 gene on Alzheimer's disease. Focus on gender, neuropsychiatric symptoms and pro-inflammatory cytokines. Curr Alzheimer Res. 2013;10:154-64 pubmed
    It was suggested that the gene encoding for sorLa, (SORL1) may affect Alzheimer's disease (LOAD) through a female-specific mechanism...
  60. Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, et al. SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease. J Alzheimers Dis. 2013;35:387-94 pubmed publisher
    ..Case-control haplotype analysis demonstrated that some haplotypes are associated with LOAD in both LD regions. Our replication study strongly supports the preceding evidence that SORL1 is likely one of the genes associated with LOAD. ..
  61. Jin C, Liu X, Zhang F, Wu Y, Yuan J, Zhu J, et al. An updated meta-analysis of the association between SORL1 variants and the risk for sporadic Alzheimer's disease. J Alzheimers Dis. 2013;37:429-37 pubmed publisher
    ..nucleotide polymorphisms (SNPs) of the sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) are associated with late-onset AD in Caucasian populations...
  62. Bajari T, Winnicki W, Gensberger E, Scharrer S, Regele H, Aumayr K, et al. Known players, new interplay in atherogenesis: Chronic shear stress and carbamylated-LDL induce and modulate expression of atherogenic LR11 in human coronary artery endothelium. Thromb Haemost. 2014;111:323-32 pubmed publisher
    ..We demonstrated the expression of pro-atherogenic LDL receptor relative (LR11) for the first time in human coronary artery endothelial cells (HCAEC) in vitro and in vivo...
  63. Yu Y, Mingjiao W, Yang X, Sui M, Zhang T, Liang J, et al. Association between DNA methylation of SORL1 5'-flanking region and mild cognitive impairment in type 2 diabetes mellitus. Ann Endocrinol (Paris). 2016;77:625-632 pubmed publisher
    ..05). These results suggested that the DNA methylation of the SORL1 5'-flanking region may significantly influence the manifestation of mild cognitive impairment in T2DM, and might be associated with its neurocognitive presentation. ..
  64. Takahashi M, Bujo H, Jiang M, Noike H, Saito Y, Shirai K. Enhanced circulating soluble LR11 in patients with coronary organic stenosis. Atherosclerosis. 2010;210:581-4 pubmed publisher
    b>LR11, an LDL receptor family member, is expressed in intimal smooth muscle cells...
  65. Jin C, Zhang L, Xian Y, Liu X, Wu Y, Zhang F, et al. The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer's disease in the Han Chinese population. Neurosci Lett. 2014;563:80-4 pubmed publisher
    ..These findings suggest that the SORL1 SNP rs985421 may alter the risk for sporadic AD and aMCI in the Han Chinese population. ..
  66. Pallesen L, Vaegter C. Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins. Mol Neurobiol. 2012;45:379-87 pubmed publisher
    Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane receptors differentially expressed in neuronal tissues of the central and peripheral nervous system...
  67. Gao X, Liu M, Sun L, Qin B, Yu H, Yang Z, et al. SORL1 genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese. Int J Neurosci. 2014;124:296-301 pubmed publisher
    ..377], while the TTC haplotype at SNPs 19-23-24 was associated with a decreased risk (OR 0.708). These results indicated that the SNPs in the 3' region of SORL1 are associated with aMCI in northern Han Chinese. ..
  68. Shiba T, Bujo H, Takahashi M, Sato Y, Jiang M, Hori Y, et al. Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2013;251:2689-95 pubmed publisher
    To evaluate the vitreous fluid levels of soluble LR11 (sLR11), a novel circulating marker for proliferative diabetic retinopathy (PDR), in patients with PDR and non-PDR (NPDR) in comparison to those in patients with non-diabetic ocular ..
  69. Schmidt V, Subkhangulova A, Willnow T. Sorting receptor SORLA: cellular mechanisms and implications for disease. Cell Mol Life Sci. 2017;74:1475-1483 pubmed publisher
    Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell...