Gene Symbol: LPAR2
Description: lysophosphatidic acid receptor 2
Alias: EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2, G protein-coupled receptor, LPA receptor 2, LPA receptor EDG4, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, lysophosphatidic acid receptor EDG4, lysophosphatidic acid receptor Edg-4
Species: human
Products:     LPAR2

Top Publications

  1. An S, Bleu T, Hallmark O, Goetzl E. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem. 1998;273:7906-10 pubmed
    ..A human cDNA encoding a G protein-coupled receptor, designated Edg4, was identified by searching the GenBankTM for homologs of the human Edg2 LPA receptor...
  2. Goetzl E, Dolezalova H, Kong Y, Hu Y, Jaffe R, Kalli K, et al. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res. 1999;59:5370-5 pubmed
    ..Thus the Edg-4 R may represent a distinctive marker of OCC that transduces growth-promoting signals from the high local concentrations of LPA characteristic of aggressive ovarian cancer. ..
  3. Fujita T, Miyamoto S, Onoyama I, Sonoda K, Mekada E, Nakano H. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. Cancer Lett. 2003;192:161-9 pubmed
    ..617, P<0.0001; gamma=0.431, P<0.001) in patients with cancer. These results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis. ..
  4. Oh Y, Jo N, Choi J, Kim H, Seo S, Kang K, et al. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol. 2004;24:5069-79 pubmed
    ..Overall, the results suggest that a ternary complex composed of LPA(2), NHERF2, and PLC-beta3 may play a key role in the LPA(2)-mediated PLC-beta signaling pathway. ..
  5. Yun C, Sun H, Wang D, Rusovici R, Castleberry A, Hall R, et al. LPA2 receptor mediates mitogenic signals in human colon cancer cells. Am J Physiol Cell Physiol. 2005;289:C2-11 pubmed
    ..LPA mediates its effects predominantly through the G protein-coupled receptors LPA1, LPA2, and LPA3...
  6. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629-83 pubmed
    ..One has to conclude that the physiological regulation of the OT system will remain puzzling as long as the molecular mechanisms of genomic and nongenomic actions of steroids have not been clarified...
  7. Suzuki N, Yoshioka N, Uekawa A, Matsumura N, Tozawa A, Koike J, et al. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Int J Gynecol Cancer. 2010;20:212-9 pubmed publisher
    ..Clear cell adenocarcinoma shows little response to standard therapy. The results of this study suggested that the transcription factor POU6F1 could be a new molecular target for treatment of this cancer. ..
  8. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Knockdown of TRIB3 decreases colon neoplasia in mice, migration of CRC cells, and their growth as xenograft tumors in mice. Strategies to block TRIB3 activity might be developed for treatment of CRC. ..
  9. Ubuka T, Tsutsui K. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Gen Comp Endocrinol. 2014;209:148-61 pubmed publisher

More Information

Publications153 found, 100 shown here

  1. Xu K, Ma L, Li Y, Wang F, Zheng G, Sun Z, et al. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension. Hypertension. 2015;66:641-6 pubmed publisher
    ..by genotyping 28 single-nucleotide polymorphisms from genes encoding for lysophosphatidic acid receptors, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6 and their flanking sequences, in 3 Han Chinese cohorts consisting of 2630 patients ..
  2. Scherer S, Cain M, Kanai S, Kaltenbronn K, Blumer K. Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit G?13. J Biol Chem. 2017;292:9906-9918 pubmed publisher
    ..This mechanism expands the diversity of functions whereby R7-RGS complexes regulate critical aspects of nervous system development and function. ..
  3. Rayner B, Ramesar R. The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment. Int J Mol Sci. 2015;16:5741-9 pubmed publisher
    ..It may also underlie the difference in hypertension between different geographically derived population groups, and form a basis for pharmacogenomic approaches to treatment of hypertension. ..
  4. Prud homme G, Glinka Y, Wang Q. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmun Rev. 2015;14:1048-56 pubmed publisher
    ..However, the immune effects of GABAergic drugs in patients are not well documented. GABAergic immunobiology is a recent area of research, which shows potential for the development of new therapies for autoimmune diseases. ..
  5. Connor E, Evock Clover C, Walker M, Elsasser T, Kahl S. COMPARATIVE GUT PHYSIOLOGY SYMPOSIUM: Comparative physiology of glucagon-like peptide-2: Implications and applications for production and health of ruminants. J Anim Sci. 2015;93:492-501 pubmed publisher
    ..g., through specific feed additives), which are more likely to achieve consumer acceptance, are needed. Opportunities to address these challenges are discussed. ..
  6. Waśniewski T, Woclawek Potocka I. Altered expression of lysophosphatidic acid receptors, in association with the synthesis of estrogens and androgens in type 1 endometrial cancer biology. Gynecol Endocrinol. 2017;:1-6 pubmed publisher
    To establish association between two main lysophosphatidic acid (LPA) receptors (LPAR2 and LPAR1) with the synthesis of estrogens and androgens in type-1 endometrial carcinoma (EC), we evaluated correlation of LPARs expression with ..
  7. Polhemus D, Gao J, Scarborough A, Trivedi R, McDonough K, Goodchild T, et al. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Circ Res. 2016;119:470-80 pubmed publisher
    ..These findings provide new insights into the remote cardioprotective effects of RF-RDN acting directly on cardiac myocytes to attenuate cell death and protect against ischemic injury. ..
  8. Khan T, Ahmad R, Azad I, Raza S, Joshi S, Khan A. Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone. Comput Biol Chem. 2018;75:178-195 pubmed publisher
  9. Yang B, Wang L, Wan X, Li Y, Yu X, Qin Y, et al. Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis. BMC Womens Health. 2017;17:118 pubmed publisher
    ..b>LPA2-5 staining were localized to the nuclei of stromal and glandular cells...
  10. Ambrożewicz E, Wojcik P, Wroński A, Łuczaj W, Jastrząb A, Zarkovic N, et al. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients. Cells. 2018;7: pubmed publisher
    ..In addition, increased expression of CB1 receptors leads to increased oxidative stress, lipid modifications, and inflammation, which, in turn, may promote the progression of psoriasis into the advanced, arthritic form of the disease. ..
  11. Seemann S, Lupp A. Administration of AMD3100 in endotoxemia is associated with pro-inflammatory, pro-oxidative, and pro-apoptotic effects in vivo. J Biomed Sci. 2016;23:68 pubmed
  12. Nah S. Gintonin: a novel ginseng-derived ligand that targets G protein- coupled lysophosphatidic acid receptors. Curr Drug Targets. 2012;13:1659-64 pubmed
  13. Ptaszynska M, Pendrak M, Stracke M, Roberts D. Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration. Mol Cancer Res. 2010;8:309-21 pubmed publisher
    ..Knockdown of ATX expression significantly decreased mRNA levels for the receptors LPA1, LPA2, S1P1, S1P2, S1P3, and VEGFR2 and abolished cell migration to lysophosphatidylcholine, LPA, recombinant ATX, and ..
  14. Raffetto J, Qiao X, Beauregard K, Khalil R. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010;51:972-81 pubmed publisher
    ..The decreased venous contraction and enhanced E2/ER-mediated venous relaxation would lead to more distensible veins in female rats. ..
  15. Chow E, Quach H, Zhang Y, Wang J, Evans D, Li A, et al. Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. J Pharmacol Exp Ther. 2017;360:174-191 pubmed
  16. Li M, Chen W, Wang L, Sun J, Zhou L, Shi Y, et al. RLA8-A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis. J Pharmacol Exp Ther. 2019;369:67-77 pubmed publisher
  17. Yue Z, Yu M, Zhang X, Wang J, Ru S. The anti-androgenic effect of chronic exposure to semicarbazide on male Japanese flounder (Paralichthys olivaceus) and its potential mechanisms. Comp Biochem Physiol C Toxicol Pharmacol. 2018;210:30-34 pubmed publisher
  18. Hanafi N, Mohamed A, Sheikh Abdul Kadir S, Othman M. Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart. Biomolecules. 2018;8: pubmed publisher
    ..This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart. ..
  19. Fatima A, Waters S, O Boyle P, Seoighe C, Morris D. Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. BMC Genomics. 2014;15:28 pubmed publisher
    ..This study highlights the potential role of miRNAs in transcription regulation of hepatic gene expression during SNEB in dairy cattle. ..
  20. Kächele M, Hennige A, Machann J, Hieronimus A, Lamprinou A, Machicao F, et al. Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers. PLoS ONE. 2015;10:e0144494 pubmed publisher
    ..Even though the molecular pathways connecting PI3Kγ and HDL metabolism remain to be further elucidated, this finding could add a novel aspect to the pathophysiological role of PI3Kγ in atherogenesis. ..
  21. Mittal S, Khole S, Jagadish N, Ghosh D, Gadgil V, Sinkar V, et al. Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling. Biochim Biophys Acta. 2016;1860:2377-2390 pubmed publisher
    ..We speculate that andrographolide can be used as a therapeutic drug to combat oxidative stress implicated in pathogenesis of various diseases such as diabetes, osteoporosis, neurodegenerative diseases etc. ..
  22. Pierce M, Mehrotra S, Mustoe A, French J, Murray T. A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors. Mol Pharmacol. 2019;95:376-385 pubmed publisher
    ..Evaluation of the influence of apamin, charybdotoxin, paxilline, and TRAM-34 demonstrated involvement of both intermediate and large conductance Ca2+-activated K+ channels. ..
  23. Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth J. Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin. MBio. 2014;5:e02190 pubmed publisher
    ..In particular, modulation of G protein-coupled receptor activity in osteoclast progenitors by small molecules might be of specific interest. ..
  24. Parker B, Wertz S, Pollard C, Desimine V, Maning J, McCrink K, et al. Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease. Int J Mol Sci. 2018;19: pubmed publisher
    ..Novel findings revealing non-conventional roles of GPCR signaling molecules, specifically of GPCR-kinase (GRK)-5, in cardiac MR regulation are also highlighted. ..
  25. Howick K, Wallace Fitzsimons S, Kandil D, Chruscicka B, Caliş M, Murphy E, et al. A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. Int J Mol Sci. 2018;19: pubmed publisher
    ..Further mechanistic studies are required in order to confirm efficacy as a ghrelinergic bioactive in susceptible population groups. ..
  26. Zhu F, Ji X, Zhong X, Hu H, Liang L, Chen J, et al. [Effects of mild hypothermia on β-adrenergic signaling pathway in a cardiac arrest swine model]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:134-139 pubmed publisher
    ..45±0.05 vs. 0.80±0.08, P < 0.05). Mild hypothermia can reduce the degree of cardiac function injury after CPR, and its mechanism may be related to the reduction of impaired myocardial β-AR signaling after CPR. ..
  27. Mata K, Li W, Reslan O, Siddiqui W, Opsasnick L, Khalil R. Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol. 2015;309:H1679-96 pubmed publisher
    ..GPER may contribute to aortic relaxation while enhanced ER? expression could mediate other genomic vascular effects during pregnancy. ..
  28. Charron M, Vuguin P. Lack of glucagon receptor signaling and its implications beyond glucose homeostasis. J Endocrinol. 2015;224:R123-30 pubmed publisher
    ..These findings suggest that glucagon signaling plays an important role in multiple organs. Thus, treatment options designed to block Gcgr activation in diabetics may have implications beyond glucose homeostasis. ..
  29. De Buck M, Berghmans N, Pörtner N, Vanbrabant L, Cockx M, Struyf S, et al. Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. J Leukoc Biol. 2015;98:1049-60 pubmed publisher
    ..g., lipopolysaccharide) inflammatory mediators induce primary chemoattractants such as serum amyloid A that synergize in an autocrine (monocyte) or a paracrine (neutrophil) fashion with secondary chemokines induced in stromal cells. ..
  30. Liu H, Pathak P, Boehme S, Chiang J. Cholesterol 7?-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. J Lipid Res. 2016;57:1831-1844 pubmed
    ..Maintaining bile acid and cholesterol homeostasis is important for protecting against liver injury and nonalcoholic fatty liver disease. ..
  31. Castillo Chabeco B, Figueroa G, Parira T, Napuri J, Agudelo M. Ethanol-induced modulation of GPR55 expression in human monocyte-derived dendritic cells is accompanied by H4K12 acetylation. Alcohol. 2018;71:25-31 pubmed publisher
  32. Fiorucci S, Zampella A, Cirino G, Bucci M, Distrutti E. Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators. Am J Physiol Heart Circ Physiol. 2017;312:H21-H32 pubmed publisher
    ..The identification of GPBAR1 as a vasodilatory receptor is of relevance in the treatment of complex disorders including metabolic syndrome-associated diseases, liver steatohepatitis, and portal hypertension. ..
  33. Schrage R, Kostenis E. Functional selectivity and dualsteric/bitopic GPCR targeting. Curr Opin Pharmacol. 2017;32:85-90 pubmed publisher
    ..Therefore, the dualsteric/bitopic design principle is most promising to facilitate generation of structurally diverse biased agonists at G protein-coupled receptors. ..
  34. Emery A, Xu W, Eiden M, Eiden L. Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells. J Biol Chem. 2017;292:12220-12231 pubmed publisher
  35. He Y, Lv B, Huan Y, Liu B, Li Y, Jia L, et al. Zhenbao pill protects against acute spinal cord injury via miR-146a-5p regulating the expression of GPR17. Biosci Rep. 2018;38: pubmed publisher
    ..Zhenbao pill could inhibit neuronal apoptosis by regulating miR-146a-5p/GPR17 expression, and then promoting the recovery of spinal cord function. ..
  36. Berecki G, Motin L, Adams D. Voltage-Gated R-Type Calcium Channel Inhibition via Human μ-, δ-, and κ-opioid Receptors Is Voltage-Independently Mediated by Gβγ Protein Subunits. Mol Pharmacol. 2016;89:187-96 pubmed publisher
    ..3 channels as potential targets for opioid analgesics. Their novel modulation is dependent on pre-existing OR activity and mediated by membrane-delimited Gβγ subunits in a voltage-independent manner. ..
  37. Pi M, Kapoor K, Ye R, Nishimoto S, Smith J, Baudry J, et al. Evidence for Osteocalcin Binding and Activation of GPRC6A in ?-Cells. Endocrinology. 2016;157:1866-80 pubmed publisher
    ..These data establish the structural basis for Ocn direct activation of GPRC6A and confirm a role for GPRC6A in regulating ?-cell proliferation and insulin secretion. ..
  38. Wanka L, Babilon S, Burkert K, Mörl K, Gurevich V, Beck Sickinger A. C-terminal motif of human neuropeptide Y4 receptor determines internalization and arrestin recruitment. Cell Signal. 2017;29:233-239 pubmed publisher
    ..Thus, we identified the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis. ..
  39. Merlini L, Khalili B, Dudin O, Michon L, Vincenzetti V, Martin S. Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating. J Cell Biol. 2018;217:1467-1483 pubmed publisher
    ..We propose that negative feedback control of Ras activity restrains the MAPK signal and couples fusion with cell-cell engagement. ..
  40. Perry H, Huang L, Ye H, Liu C, Sung S, Lynch K, et al. Endothelial Sphingosine 1‑Phosphate Receptor‑1 Mediates Protection and Recovery from Acute Kidney Injury. J Am Soc Nephrol. 2016;27:3383-3393 pubmed
    ..Endothelial S1P1 may be a therapeutic target for the prevention of early injury as well as prevention of progressive kidney fibrosis after AKI. ..
  41. Janero D, Thakur G. Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target. Expert Opin Drug Discov. 2016;11:1223-1237 pubmed
    ..The resulting data should expand the repertoire of novel agents capable of exerting therapeutic benefit by modulating CB1R-dependent signaling. ..
  42. Guinzberg R, Díaz Cruz A, Acosta Trujillo C, Vilchis Landeros M, Vázquez Meza H, Lozano Flores C, et al. Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity. FEBS J. 2017;284:258-276 pubmed publisher
    ..Thus, each signalosome is devoted to ensure the transmission of a unique and unequivocal message through the cell. ..
  43. Zhai P, Ma L, Liu X. [Research progress in signal bias of G protein-coupled receptor and its mechanism]. Sheng Li Xue Bao. 2016;68:790-798 pubmed
    ..These studies will provide new insights into new drug discovery. ..
  44. Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, et al. GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss. J Med Genet. 2017;54:426-430 pubmed publisher
    ..This study presented a novel X-linked SHL combined with unique and unrecognised clinical features, and a missense variation of GPRASP2 was first identified to be implicated in X-linked SHL. ..
  45. Krause A, Zisowsky J, Strasser D, Gehin M, Sidharta P, Groenen P, et al. Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection. Clin Pharmacokinet. 2016;55:813-821 pubmed publisher
    ..Ninety percent of maximum blockade of CRTH2 internalization at trough is suggested as a quantitative PD target in clinical studies. ..
  46. Murata K, Ishida J, Ishimaru T, Mizukami H, Hamada J, Saito C, et al. Lactation Is a Risk Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression. J Biol Chem. 2016;291:11241-51 pubmed publisher
  47. Iacovazzo D, Caswell R, Bunce B, Jose S, Yuan B, Hernández Ramírez L, et al. Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study. Acta Neuropathol Commun. 2016;4:56 pubmed publisher
    ..3 region. The pathological features of XLAG-associated pituitary adenomas are typical and, together with the clinical phenotype, should prompt genetic testing. ..
  48. Li T, Hu J, Gao F, Du X, Chen Y, Wu Q. Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy. Sci Rep. 2017;7:45807 pubmed publisher
    ..Our data suggest that activation of the GPR91-ERK1/2-C/EBP β (c-Fos, HIF-1α) signaling pathway plays a tonic role in regulating VEGF transcription in rat retinal ganglion cells. ..
  49. Tena Campos M, Ramon E, Borroto Escuela D, Fuxe K, Garriga P. The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity. Biochim Biophys Acta. 2015;1852:2585-92 pubmed publisher
    ..These findings provide a rationale for the antidepressive effect widely described for zinc because pro-depressive heterocomplexes are predominant at low zinc concentration levels. ..
  50. Feng X, Duan H, Li S. Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. Int J Mol Med. 2017;40:922-930 pubmed publisher
    ..The results indicate that PTF exerts a protective role against PA-induced impairment of GSIS involving GPR40 signaling in INS-1 cells. ..
  51. Godbole A, Lyga S, Lohse M, Calebiro D. Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription. Nat Commun. 2017;8:443 pubmed publisher
    ..Here the authors use fluorescence microscopy approaches to directly visualize and investigate functional consequences of GPCR-mediated signaling at the Golgi/trans-Golgi network. ..
  52. Kulkarni N, Meitei H, Sonar S, Sharma P, Mujeeb V, Srivastava S, et al. CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation. J Autoimmun. 2018;88:121-130 pubmed publisher
    ..Furthermore, CCR6 signaling induced phosphorylation of Akt, mTOR, and STAT3 molecules in T cells. In conclusion, we have identified a new role of CCR6 signaling in the differentiation of iTregs during inflammation and gut autoimmunity. ..
  53. Tang Y, Wu Y, Herlihy S, Brito Aleman F, Ting J, Janetopoulos C, et al. An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH. MBio. 2018;9: pubmed publisher
    ..In this study, we found that a eukaryotic microbe uses G protein-coupled receptors to mediate both cell density sensing and chemorepulsion. ..
  54. Fresia C, Vigliarolo T, Guida L, Booz V, Bruzzone S, Sturla L, et al. G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2. Sci Rep. 2016;6:26658 pubmed publisher
    ..Nuclear enrichment of native LANCL2 is also induced by ABA treatment. Therefore human LANCL2 is a non-transmembrane G protein-coupled receptor susceptible to hormone-induced nuclear translocation. ..
  55. Nogués L, Reglero C, Rivas V, Salcedo A, Lafarga V, Neves M, et al. G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis. EBioMedicine. 2016;13:132-145 pubmed publisher
    ..Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 and Pin1. ..
  56. Kangussu L, Almeida Santos A, Moreira F, Fontes M, Santos R, Aguiar D, et al. Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1-7): Role of the Mas receptor. Behav Brain Res. 2017;331:193-198 pubmed publisher
    ..Therefore, facilitation of the Ang-(1-7)/Mas receptor signaling may be further investigated as an additional strategy for the treatment of anxiety-related disorders. ..
  57. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, et al. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2018;142:470-484.e12 pubmed publisher
    ..17,18-EpETE inhibits neutrophil mobility through GPR40 activation, which is a potential therapeutic target to control allergic inflammatory diseases. ..
  58. Park J, Lee S, Kim H, Seo M, Chung K. Structural mechanism of GPCR-arrestin interaction: recent breakthroughs. Arch Pharm Res. 2016;39:293-301 pubmed publisher
    ..This review will discuss the recent breakthroughs in the conformational understanding of GPCR-arrestin interaction. ..
  59. Tae H, Petrashevskaya N, Kim I, Park J, Lee J, Won M, et al. G protein, phosphorylated-GATA4 and VEGF expression in the hearts of transgenic mice overexpressing β1- and β2-adrenergic receptors. Mol Med Rep. 2017;15:4049-4054 pubmed publisher
  60. Yue Z, Yu M, Zhao H, Wang J, Zhang X, Tian H, et al. The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms. Mar Pollut Bull. 2018;129:806-812 pubmed publisher
    ..Our results demonstrated for the first time that environmentally relevant concentrations of SMC exerted anti-estrogenicity in female flounders, providing theoretical support for ecological risk assessments of SMC in marine environments. ..
  61. Marino K, Filizola M. Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations. Methods Mol Biol. 2018;1705:351-364 pubmed publisher
    ..Here, we discuss possible ways to study the dynamics involved in the binding of small molecules to GPCRs, using long timescale MD simulations or metadynamics-based approaches. ..
  62. Maruyama K, McGuire J, Kagota S. Progression of Time-Dependent Changes to the Mechanisms of Vasodilation by Protease-Activated Receptor 2 in Metabolic Syndrome. Biol Pharm Bull. 2017;40:2039-2044 pubmed publisher
    ..Furthermore, we discuss the implications of these age-related changes in PAR2 for the cardiovascular system in metabolic syndrome...
  63. Ren H, Cook J, Kon N, Accili D. Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin. Diabetes. 2015;64:3670-9 pubmed publisher
    ..In summary, AgRP neuron-specific Gpr17 knockouts phenocopy FOXO1 knockouts in the same cell type, thus supporting our original hypothesis and providing further impetus to develop Gpr17 antagonists for the treatment of obesity. ..
  64. Rezq S, Abdel Rahman A. Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats. J Pharmacol Exp Ther. 2016;356:456-65 pubmed publisher
    ..Further, GPR109A knockdown (siRNA) abrogated the biochemical effects of NA in PC12 cells. These novel findings yield new insight into the role of RVLM GPR109A in central BP control. ..
  65. Altara R, Manca M, Brandão R, Zeidan A, Booz G, Zouein F. Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases. Clin Sci (Lond). 2016;130:463-78 pubmed publisher
    ..In this review, we provide evidence to support our contention that CXCR3 and its ligands actively participate in the development and progression of CVDs, and may additionally have utility as diagnostic and prognostic biomarkers. ..
  66. Bayin N, Frenster J, Kane J, Rubenstein J, Modrek A, Baitalmal R, et al. GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016;5:e263 pubmed publisher
    ..We propose that GPR133 represents a novel molecular target in GBM and possibly other malignancies where hypoxia is fundamental to pathogenesis. ..
  67. Lecat Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier J, et al. FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chem Biol. 2017;24:360-370 pubmed publisher
    ..Our study brings important new information on the activation mechanism of the GABAB receptor and should facilitate the screening and identification of new chemicals targeting this receptor. ..
  68. Liu H, Zhang Y, Hao X, Kong F, Li X, Yu J, et al. GPRC5A overexpression predicted advanced biological behaviors and poor prognosis in patients with gastric cancer. Tumour Biol. 2016;37:503-10 pubmed publisher
    ..Our results suggested that elevated levels of GPRC5A played significant roles in GC progression. GPRC5A could serve as a prognostic biomarker of GC. ..
  69. Zhang M, Davis J, Li C, Gao J, Huang W, Lambert N, et al. GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. Mol Cell Biol. 2016;36:1152-63 pubmed publisher
    ..These data reveal a novel function of GGA3 in export trafficking of a GPCR that is mediated via a specific interaction with the receptor. ..
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