Gene Symbol: LPAR1
Description: lysophosphatidic acid receptor 1
Alias: EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1, lysophosphatidic acid receptor 1, LPA receptor 1, LPA-1, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, lysophosphatidic acid receptor Edg-2, ventricular zone gene 1
Species: human
Products:     LPAR1

Top Publications

  1. Guo R, Kasbohm E, Arora P, Sample C, Baban B, Sud N, et al. Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells. Endocrinology. 2006;147:4883-92 pubmed
    ..These results suggest the possible utility of LPA(1) as a drug target to interfere with progression of prostate cancer. ..
  2. Lin C, Chen C, Huang M, Lee S, Lin C, Chang C, et al. Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms. Cell Signal. 2008;20:1804-14 pubmed publisher
  3. van Leeuwen F, Olivo C, Grivell S, Giepmans B, Collard J, Moolenaar W. Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. J Biol Chem. 2003;278:400-6 pubmed
    ..Here we report that the prototypic LPA(1) receptor (previously named Edg2), when expressed in B103 neuroblastoma cells, mediates transient activation of RhoA and robust, prolonged ..
  4. Ferreira M, Hottenga J, Warrington N, Medland S, Willemsen G, Lawrence R, et al. Sequence variants in three loci influence monocyte counts and erythrocyte volume. Am J Hum Genet. 2009;85:745-9 pubmed publisher
    ..The first was located in an intergenic region of chromosome 9q31 near LPAR1, explaining 1.5% of the variation in monocyte counts (best SNP rs7023923, p=8.9x10(-14))...
  5. Zhao C, Fernandes M, Prestwich G, Turgeon M, Di Battista J, Clair T, et al. Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?. Mol Pharmacol. 2008;73:587-600 pubmed
    ..The above results provide novel insights into the relevance of LPA receptors in FLS biology and as potential therapeutic targets for the treatment of RA. ..
  6. Hecht J, Weiner J, Post S, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol. 1996;135:1071-83 pubmed
    ..Vzg-1 therefore provides a link between extracellular LPA and the activation of LPA-mediated signaling pathways through a single receptor and will allow new investigations into LPA signaling both in neural and nonneural systems. ..
  7. Shida D, Kitayama J, Yamaguchi H, Okaji Y, Tsuno N, Watanabe T, et al. Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. Cancer Res. 2003;63:1706-11 pubmed
    ..Northern blot analysis revealed that DLD1 highly expressed LPA1/Edg-2 but showed only low expression of LPA2/Edg-4 and no expression of LPA3/Edg-7 at the mRNA level...
  8. Bernhart E, Kollroser M, Rechberger G, Reicher H, Heinemann A, Schratl P, et al. Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics. 2010;10:141-58 pubmed publisher
    ..This might be of particular relevance in the pathophysiological context of neurodegenerative disorders where LPA concentrations can be significantly elevated in the CNS. ..
  9. Funke M, Zhao Z, Xu Y, Chun J, Tager A. The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury. Am J Respir Cell Mol Biol. 2012;46:355-64 pubmed publisher

More Information

Publications120 found, 100 shown here

  1. Horak C, Mendoza A, Vega Valle E, Albaugh M, Graff Cherry C, McDermott W, et al. Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res. 2007;67:11751-9 pubmed
    Nm23-H1 transcriptionally down-regulates expression of the lysophosphatidic acid receptor EDG2 and this down-regulation is critical for Nm23-H1-mediated motility suppression in vitro...
  2. Lee B, Kim J, Lee R, Choi S, Kim H, Hwang S, et al. Gintonin enhances performance of mice in rotarod test: Involvement of lysophosphatidic acid receptors and catecholamine release. Neurosci Lett. 2016;612:256-260 pubmed publisher
    ..This elevation in blood glucose level could be abrogated by the LPA1/3 receptor antagonist, Ki16425, or the β-adrenergic receptor antagonist, propranolol...
  3. Jang M, Choi J, Chang Y, Lee S, Nah S, Cho I. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors. Brain Behav Immun. 2019;: pubmed publisher
    ..These beneficial effects of GT were neutralized by pre-inhibiting LPARs with Ki16425 (a LPAR1/3 antagonist). Interestingly, GT reduced cell death and mutant huntingtin (HTT) aggregates in STHdh cells...
  4. Morimoto Y, Ishii S, Ishibashi J, Katoh K, Tsujiuchi T, Kagawa N, et al. Functional lysophosphatidic acid receptors expressed in Oryzias latipes. Gene. 2014;551:189-200 pubmed publisher
    ..medaka genome database, we examine the genomic structures, expression, and functions of six LPA receptor genes, Lpar1-Lpar6...
  5. Buniello A, Hardisty Hughes R, Pass J, Bober E, Smith R, Steel K. Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS ONE. 2013;8:e56274 pubmed publisher
    ..is caused by: 1) effect of a 648 kb deletion on distal Chr7, resulting in the loss of three protein coding genes (Gpr26, Cpmx2 and Chst15) with expression in the inner ear but unknown function; and 2) indirect, long range effect of ..
  6. Zhao Y, Hasse S, Zhao C, Bourgoin S. Targeting the autotaxin - Lysophosphatidic acid receptor axis in cardiovascular diseases. Biochem Pharmacol. 2019;164:74-81 pubmed publisher
    ..LPA initiates cellular signalling pathways upon binding to and activation of its G protein-coupled receptors (LPA1-6)...
  7. Wu L, Petrigliano F, Ba K, Lee S, Bogdanov J, McAllister D, et al. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Osteoarthritis Cartilage. 2015;23:308-18 pubmed publisher
    ..articular cartilage in rat and humans expressed negligible levels of ATX despite expressing the LPA receptors LPAR1 and LPAR2...
  8. Balogh A, Shimizu Y, Lee S, Norman D, Gangwar R, Bavaria M, et al. The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair. Cell Signal. 2015;27:1751-62 pubmed publisher
    ..In LPA2-reconstituted MEF cells lacking LPA1&3 the levels of γ-H2AX decreased rapidly, whereas in Vector MEF were high and remained sustained...
  9. Denton C. Systemic sclerosis: from pathogenesis to targeted therapy. Clin Exp Rheumatol. 2015;33:S3-7 pubmed
    ..cytokine signalling, including IL-6, and from other immune-inflammatory therapies including lipid mediators such as LPA1. Other approaches to modulate TGFbeta and other profibrotic pathways also have potential although safety and ..
  10. Lei L, Su J, Chen J, Chen W, Chen X, Peng C. The role of lysophosphatidic acid in the physiology and pathology of the skin. Life Sci. 2019;220:194-200 pubmed publisher
    ..After targeting to endothelial differentiation gene (Edg) family LPA receptors (LPA1, LPA2, LPA3) and non-Edg family LPA receptors (LPA4, LPA5, LPA6), LPA mediates physiological and pathological ..
  11. Dong L, Yuan Y, Opansky C, Chen Y, Aguilera Barrantes I, Wu S, et al. Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Oncotarget. 2017;8:22550-22562 pubmed publisher
    ..vascular endothelial growth factor receptor 2 (VEGFR 2) and endothelial differentiation gene 2/LPA receptor1 (Edg2/LPA1), enhanced PKD-1 phosphorylation, and reduced CD36 expression...
  12. Liang B, Li C, Zhao J. Identification of key pathways and genes in colorectal cancer using bioinformatics analysis. Med Oncol. 2016;33:111 pubmed publisher
    ..The top 10 hub genes, GNG2, AGT, SAA1, ADCY5, LPAR1, NMU, IL8, CXCL12, GNAI1, and CCR2 were identified from the PPI network, and sub-networks revealed these genes ..
  13. Vázquez Medina J, Dodia C, Weng L, Mesaros C, Blair I, Feinstein S, et al. The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J. 2016;30:2885-98 pubmed publisher
    ..Thus, Prdx6-PLA2 modulates NOX2 activation through generation of LPC for conversion to LPA; binding of LPA to LPAR1 signals rac activation.-Vázquez-Medina, J. P., Dodia, C., Weng, L., Mesaros, C., Blair, I. A., Feinstein, S. I...
  14. Somma G, Alger H, McGuire R, Kretlow J, Ruiz F, Yatsenko S, et al. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. J Assoc Res Otolaryngol. 2012;13:335-49 pubmed publisher
    ..The three known genes (Gpr26, Cpxm2, and Chst15) in the deleted region are conserved in mammals and expressed in the wild-type inner ear during ..
  15. Plastira I, Bernhart E, Goeritzer M, Reicher H, Kumble V, Kogelnik N, et al. 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype. J Neuroinflammation. 2016;13:205 pubmed publisher
    ..BV-2 cells express LPA receptor 2 (LPA2), 3, 5, and 6, whereas PMM express LPA1, 2, 4, 5, and 6...
  16. Sinderewicz E, Grycmacher K, Boruszewska D, Kowalczyk Zieba I, Staszkiewicz Chodor J, Łukaszuk K, et al. Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows. Anim Reprod Sci. 2018;192:242-250 pubmed publisher
    ..Greater expression of LPAR1-3 and AX genes were detected in the healthy follicles compared to the atretic and transitional follicles (P?<?0...
  17. Kang S, Han J, Song S, Kim W, Shin S, Kim J, et al. Lysophosphatidic acid increases the proliferation and migration of adipose‑derived stem cells via the generation of reactive oxygen species. Mol Med Rep. 2015;12:5203-10 pubmed publisher
    ..The LPA1 receptor is highly expressed in ASCs, and pharmacological inhibition of it by Ki16425 significantly attenuated the ..
  18. Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz T, Haubold K, et al. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cell Physiol Biochem. 2017;43:445-456 pubmed publisher
    ..bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA receptors (LPA1-6)...
  19. Hwang S, Lee B, Choi S, Kim H, Jung S, Kim H, et al. Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, stimulates neurotransmitter release. Neurosci Lett. 2015;584:356-61 pubmed publisher
    ..The induction of gintonin-mediated [Ca(2+)]i transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and ..
  20. Leve F, Peres Moreira R, Binato R, Abdelhay E, Morgado Díaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed publisher
    ..We found that the cell lines expressed LPAR1, -2 and -3 in a differential manner and that 10 μM LPA did not affect cell migration, invasion and anchorage-..
  21. Sinderewicz E, Grycmacher K, Boruszewska D, Kowalczyk Zięba I, Staszkiewicz J, Ślężak T, et al. Expression of factors involved in apoptosis and cell survival is correlated with enzymes synthesizing lysophosphatidic acid and its receptors in granulosa cells originating from different types of bovine ovarian follicles. Reprod Biol Endocrinol. 2017;15:72 pubmed publisher
    ..In the healthy follicle type, LPA, acting via LPAR1, might regulate MCL1 and estradiol-stimulating ERβ mRNA expression, leading to the stimulation of anti-..
  22. Park H, Kim S, Rhee J, Kim H, Han J, Nah S, et al. Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses. J Neurophysiol. 2015;113:1493-500 pubmed publisher
    ..Recent studies using LPAR1-deficient mice reported impaired performances in a number of behavioral tasks, including the hippocampus-dependent ..
  23. Oude Elferink R, Bolier R, Beuers U. Lysophosphatidic acid and signaling in sensory neurons. Biochim Biophys Acta. 2015;1851:61-5 pubmed publisher
    ..The molecule mainly acts through the activation of a set of at least 6 G-protein-coupled receptors (LPA1-6), but intracellular LPA was also shown to signal through the activation of the nuclear receptor PPARγ...
  24. Tagashira Y, Shimizu T, Miyamoto M, Nishida S, Yoshida K. Overexpression of a Gene Involved in Phytic Acid Biosynthesis Substantially Increases Phytic Acid and Total Phosphorus in Rice Seeds. Plants (Basel). 2015;4:196-208 pubmed publisher
    ..The rice (Oryza sativa L.) low phytic acid mutant lpa1-1 has been identified as a homolog of archael 2-phosphoglycerate kinase...
  25. Kim H, Lee B, Choi S, Kim H, Jung S, Hwang S, et al. Gintonin stimulates gliotransmitter release in cortical primary astrocytes. Neurosci Lett. 2015;603:19-24 pubmed publisher
    ..The induction of gintonin-mediated [Ca(2+)]i transients was attenuated/blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and ..
  26. Lee H, Goetzl E, An S. Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. Am J Physiol Cell Physiol. 2000;278:C612-8 pubmed
    ..of human umbilical vein endothelial cells and adult bovine aortic endothelial cells, which express LPA receptor Edg2, and S1P receptors Edg1 and Edg3...
  27. Araújo T, Khayat A, Quintana L, Calcagno D, Mourão R, Modesto A, et al. Piwi like RNA-mediated gene silencing 1 gene as a possible major player in gastric cancer. World J Gastroenterol. 2018;24:5338-5350 pubmed publisher
    ..current literature, 9 of these 35 genes (DOCK2, ZNF503, PDE4D, ABL1, ABL2, LPAR1, SMAD2, WASF3 and DACH1) are possibly related to the mechanisms used by PIWIL1 to promote ..
  28. Fan Q, Cai Q, Xu Y. FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer. Oncotarget. 2015;6:27688-99 pubmed publisher
    ..Gi-PI3K-AKT and G12/13-Rho-YAP signaling pathways were both involved in the LPA receptor (LPA1-3) mediated up-regulation of FOXM1 at the transcriptional level...
  29. Zhao Y, Zhang H. Update on the mechanisms of homing of adipose tissue-derived stem cells. Cytotherapy. 2016;18:816-27 pubmed publisher
    ..Some more signaling pathways involved in migration of ADSCs have been investigated, including LPA/LPA1 signaling pathway, MAPK/Erk1/2 signaling pathway, RhoA/Rock signaling pathway and PDGF-BB/PDGFR-? signaling pathway...
  30. Sakuraba Y, Piao W, Lim J, Han S, Kim Y, An G, et al. Rice ONAC106 Inhibits Leaf Senescence and Increases Salt Tolerance and Tiller Angle. Plant Cell Physiol. 2015;56:2325-39 pubmed publisher
    ..onac106-1D also exhibited a wide tiller angle phenotype throughout development, and the tiller angle-related gene LPA1 was down-regulated in onac106-1D...
  31. Bai Y, Chang R, Wang H, Xiao F, Ge R, Wang L. ENPP2 protects cardiomyocytes from erastin-induced ferroptosis. Biochem Biophys Res Commun. 2018;499:44-51 pubmed publisher
    ..ENPP2 overexpression leads to increase the LPA level in supernatant of H9c2 cells. H9c2 cells express the LPAR1, LPAR3, LPAR4 and LPAR5 receptors...
  32. Gotoh M, Nagano A, Tsukahara R, Murofushi H, Morohoshi T, Otsuka K, et al. Cyclic phosphatidic acid relieves osteoarthritis symptoms. Mol Pain. 2014;10:52 pubmed publisher
    ..in synoviocytes and on MMP-13 production in SW1353 cells was not mediated by the lysophosphatidic acid receptor, LPA1 receptor (LPA1R)...
  33. Yu Z, Li D, Huang X, Xing X, Yu R, Li Z, et al. Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through the GPCR/PKC and PKA pathways. Int J Mol Med. 2016;37:468-74 pubmed publisher
    ..LPA receptor1/3 was inhibited by Ki16425, a specific inhibitor of LPA1/3; as a result, the LPA-induced increase in CCN2 expression was abrogated...
  34. Igarashi H, Akahoshi N, Ohto Nakanishi T, Yasuda D, Ishii S. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Sci Rep. 2015;5:11410 pubmed publisher
    Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that acts through G protein-coupled receptors (LPA1-6). Although several biological roles of LPA4 are becoming apparent, its role in hematopoiesis has remained unknown...
  35. Kim H, Kim J, Lee B, Choi S, Rhim H, Kim H, et al. Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing. J Vet Sci. 2017;18:387-397 pubmed publisher
    ..Gintonin-mediated mobilization of [Ca2+]i was attenuated by LPA1/3 receptor antagonist Ki16425, phospholipase C inhibitor U73122, inositol 1,4,5-triphosphate receptor antagonist 2-..
  36. Cao P, Aoki Y, Badri L, Walker N, Manning C, Lagstein A, et al. Autocrine lysophosphatidic acid signaling activates ?-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017;127:1517-1530 pubmed publisher
    ..In an in vivo mouse orthotopic lung transplant model of BOS, antagonism of the LPA receptor (LPA1) or ATX inhibition decreased allograft fibrosis and was associated with lower active ?-catenin and dephosphorylated ..
  37. Sahay D, Leblanc R, Grunewald T, Ambatipudi S, Ribeiro J, Clézardin P, et al. The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. Oncotarget. 2015;6:20604-20 pubmed
    ..1488 human primary breast tumors that the gene encoding the transcription factor ZEB1 was the most correlated with LPAR1 encoding LPA1...
  38. Yamada T, Yano S, Ogino H, Ikuta K, Kakiuchi S, Hanibuchi M, et al. Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. Cancer Sci. 2008;99:1603-10 pubmed publisher
    ..Therefore, LPA and LPA receptors, LPA(2) as well as LPA(1), represent potential therapeutic targets for patients with MPM. ..
  39. Castilla Ortega E, Pavón F, Sánchez Marín L, Estivill Torrús G, Pedraza C, Blanco E, et al. Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption. Neuropharmacology. 2016;103:92-103 pubmed publisher
    ..the consequences of either genetic deletion or pharmacological blockade of lysophosphatidic acid receptor-1 (LPA1) in alcohol consumption...
  40. Khan M, He L. Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors. Psychopharmacology (Berl). 2017;234:1181-1207 pubmed publisher
    ..perspective of 26 orphan receptors of rhodopsin (class A) family, namely GPR3, GPR6, GPR12, GPR17, GPR26, GPR35, GPR39, GPR48, GPR49, GPR50, GPR52, GPR55, GPR61, GPR62, GPR63, GPR68, GPR75, GPR78, GPR83, GPR84, GPR85, ..
  41. Moreno Fernández R, Perez Martin M, Castilla Ortega E, Rosell Del Valle C, Garcia Fernandez M, Chun J, et al. maLPA1-null mice as an endophenotype of anxious depression. Transl Psychiatry. 2017;7:e1077 pubmed publisher
    ..Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid ..
  42. Chen X, Walther F, Laghmani E, Hoogeboom A, Hogen Esch A, Van Ark I, et al. Adult Lysophosphatidic Acid Receptor 1-Deficient Rats with Hyperoxia-Induced Neonatal Chronic Lung Disease Are Protected against Lipopolysaccharide-Induced Acute Lung Injury. Front Physiol. 2017;8:155 pubmed publisher
    ..Because neonatal lysophosphatidic acid receptor-1 (LPAR1)-deficient rats are protected against hyperoxia-induced lung injury, we hypothesize that LPAR1-deficiency may ..
  43. Sadam A, Parida S, Padol A, Verma A, Baba N, Khuman W, et al. Study of lysophosphatidic acid receptors (LPARs) in buffalo uterus demonstrated upregulation of LPAR1 and LPAR6 in early pregnancy. Theriogenology. 2017;99:90-97 pubmed publisher
    ..RT-PCR experiments detected mRNAs of all the six LPA receptors (LPAR1-LPAR6) in both nonpregnant, and early-pregnant endometrial tissues...
  44. Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, et al. LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. J Pharmacol Sci. 2018;136:93-96 pubmed publisher
    Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the alternation of pain-related genes/proteins expression and demyelination...
  45. An S, Bleu T, Zheng Y, Goetzl E. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol. 1998;54:881-8 pubmed
    ..In TAg-Jurkat T cells transiently co-transfected with apoaequorin and human Edg2 or Edg4 cDNA, LPA dose-dependently increased light emission triggered by increased Ca2+ bound to aequorin...
  46. Hama K, Bandoh K, Kakehi Y, Aoki J, Arai H. Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. FEBS Lett. 2002;523:187-92 pubmed
    Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin...
  47. Dancs P, Ruisanchez Ã, Balogh A, Panta C, Miklós Z, Nüsing R, et al. LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction. FASEB J. 2017;31:1547-1555 pubmed publisher
    ..Nüsing, R. M., Aoki, J., Chun, J., Offermanns, S., Tigyi, G., Benyó, Z. LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction. ..
  48. Ishii S, Tsujiuchi T, Fukushima N. Functional characterization of lysophosphatidic acid receptor 1 mutants identified in rat cancer tissues. Biochem Biophys Res Commun. 2017;486:767-773 pubmed publisher
    ..We recently found several missense mutations of Lpar1 in rat cancer tissues...
  49. Urs N, Kowalczyk A, Radhakrishna H. Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor. J Biol Chem. 2008;283:5249-57 pubmed
    Lysophosphatidic acid (LPA) stimulates cells by activation of five G-protein-coupled receptors, termed LPA 1-5. The LPA 1 receptor is the most widely expressed and is a major regulator of cell migration...
  50. Hurst J, Hooks S. Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways. Pharmacology. 2009;83:333-47 pubmed publisher
    ..Further, the LPA1/LPA3 receptor antagonist Ki16425 was more potent in SKOV-3 cells...
  51. Song H, Lee M, Kim M, Kim K, Lee I, Shin S, et al. Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis. Biochim Biophys Acta. 2010;1801:23-30 pubmed publisher
    ..Ki16425 and by small interfering RNA- or lentiviral small hairpin RNA-mediated silencing of endogenous LPA(1)/Edg2. Moreover, SF from RA patients contains higher concentrations of LPA and an LPA-producing enzyme autotoxin than ..
  52. Cominelli E, Confalonieri M, Carlessi M, Cortinovis G, Daminati M, Porch T, et al. Phytic acid transport in Phaseolus vulgaris: A new low phytic acid mutant in the PvMRP1 gene and study of the PvMRPs promoters in two different plant systems. Plant Sci. 2018;270:1-12 pubmed publisher
    ..Only a common bean low phytic acid (lpa1) mutant, affected in the PvMRP1 gene, coding for a putative tonoplastic phytic acid transporter, was described so ..
  53. Contos J, Ishii I, Chun J. Lysophosphatidic acid receptors. Mol Pharmacol. 2000;58:1188-96 pubmed
    ..To date, three mammalian cognate receptor genes, lp(A1)/vzg-1/Edg2, lp(A2)/Edg4, and lp(A3)/Edg7, have been identified that encode high-affinity LPA receptors...
  54. Ward Y, Lake R, Martin P, Killian K, Salerno P, Wang T, et al. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene. 2013;32:2726-38 pubmed publisher
    ..This study shows an autonomous effect of CD97 on thyroid cancer progression and supports the investigation of this GPCR as a therapeutic target for these cancers. ..
  55. Loskutov Y, Griffin C, Marinak K, Bobko A, Margaryan N, Geldenhuys W, et al. LPA signaling is regulated through the primary cilium: a novel target in glioblastoma. Oncogene. 2018;37:1457-1471 pubmed publisher
    ..We show that lysophosphatidic acid receptor 1 (LPAR1) is accumulated in primary cilia...
  56. Tabuchi S. The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme. Lipids Health Dis. 2015;14:56 pubmed publisher
    ..Six LPARs, named LPA1-6, are currently recognized...
  57. Mori S, Araki M, Ishii S, Hirane M, Fukushima K, Tomimatsu A, et al. LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs. Mol Cell Biochem. 2015;408:147-54 pubmed publisher
    ..The treatment of CDDP and DOX inhibited the expression levels of the LPA receptor-1 (Lpar1), Lpar2, and Lpar3 genes in F-2 cells...
  58. Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, et al. ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Sci Rep. 2016;6:23433 pubmed publisher
    ..Through gene targeting approaches in zebrafish and mice, we show here that loss of ATX-LPA1 signaling leads to disorganization of chondrocytes, causing severe defects in cartilage formation...
  59. Olianas M, Dedoni S, Onali P. LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells. J Pharmacol Exp Ther. 2016;359:340-353 pubmed
    ..The protective effects of mianserin were antagonized by AM966. These data indicate that LPA1 constitutes a novel molecular target of the regulatory actions of tricyclic and tetracyclic antidepressants in glial cells. ..
  60. Pan H, Liu B, Lin W, Zhang Y. Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain. Neurosci Bull. 2016;32:445-54 pubmed publisher
    ..pain, the present study was designed to investigate whether crosstalk between the LPA receptor LPA1 (also known as EDG2) and Nav1.8 in the dorsal root ganglion (DRG) contributes to the induction of bone cancer pain...
  61. D Souza K, Paramel G, Kienesberger P. Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance. Nutrients. 2018;10: pubmed publisher
    ..lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX)...
  62. Kim D, Jang M, Choi S, Kim H, Jhun H, Kim H, et al. Gintonin, a ginseng-derived exogenous lysophosphatidic acid receptor ligand, enhances blood-brain barrier permeability and brain delivery. Int J Biol Macromol. 2018;114:1325-1337 pubmed publisher
    ..Fluorescent-labeled gintonin bound to HBMECs and co-localized with the LPA1 receptor...
  63. Seo E, Kwon Y, Jang I, Kim D, Lee S, Choi E, et al. Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism. Stem Cells. 2016;34:551-64 pubmed publisher
    ..Treatment of CSCs with LPA receptor 1-specific inhibitors or silencing of LPA receptor 1 expression abrogated the LPA-stimulated CSC properties...
  64. Zhang M, Wang X, Yang H, Fogo A, Murphy B, Kaltenbach R, et al. Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model. J Am Soc Nephrol. 2017;28:3300-3311 pubmed publisher
    ..We examined whether BMS002, a novel dual LPAR1 and LPAR3 antagonist, affects development of DN in endothelial nitric oxide synthase-knockout db/db mice...
  65. Fukushima N, Kimura Y, Chun J. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci U S A. 1998;95:6151-6 pubmed
    ..To address this issue, we analyzed one receptor encoded by ventricular zone gene-1 (vzg-1) (also referred to as lpA1/edg-2) by using heterologous expression in a neuronal and nonneuronal cell line...
  66. An S, Goetzl E, Lee H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J Cell Biochem Suppl. 1998;30-31:147-57 pubmed
    ..This review summarizes our current understanding of signaling pathways critical for cellular responses to LPA and S1P and of recent progress in the molecular biological analyses of the Edg receptors. ..
  67. Kaneider N, Lindner J, Feistritzer C, Sturn D, Mosheimer B, Djanani A, et al. The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. FASEB J. 2004;18:1309-11 pubmed
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  69. Aziziyeh A, Li T, Pape C, Pampillo M, Chidiac P, Possmayer F, et al. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell Signal. 2009;21:1207-17 pubmed publisher
    ..Taken together, these results establish RalA and GRK2 as key regulators of LPA receptor signalling and demonstrate for the first time that LPA(1) activity facilitates the formation of a novel protein complex between these two proteins. ..
  70. Komuro Y, Watanabe T, Kitayama J, Yamaguchi H, Tsuno N, Nagawa H. The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas. Hepatogastroenterology. 2003;50:1770-3 pubmed
    ..A significant correlation between EDG-2 expression and the size of the adenomas suggests that EDG-2 may play an important role in the growth of these adenomas. ..
  71. Windischhofer W, Huber E, Rossmann C, Semlitsch M, Kitz K, Rauh A, et al. LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. Biochimie. 2012;94:1997-2005 pubmed publisher
    ..Silencing of LPA(1) and/or Egr-1 in MG-63 cells reversed LPA-mediated suppression of periostin. We here demonstrate a crosslink between Egr-1 and periostin in cancer cells, in particular in human osteosarcoma. ..
  72. Fink K, López Giráldez F, Kim I, Strittmatter S, Cafferty W. Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Rep. 2017;18:2687-2701 pubmed publisher
    ..We identify the lysophosphatidic acid signaling modulators LPPR1 and LPAR1 as intrinsic axon growth modulators for intact corticospinal motor neurons after adjacent injury...
  73. Zhao J, He D, Berdyshev E, Zhong M, Salgia R, Morris A, et al. Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. Biochem J. 2011;439:45-55 pubmed publisher
    ..In addition we also demonstrated association of ATX with the epithelial cell-surface LPA receptor and integrin ?4. ..
  74. Okabe K, Hayashi M, Fujii M, Honoki K, Mori T, Fukushima N, et al. Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells. Pathobiology. 2010;77:278-82 pubmed publisher
    ..of LPA receptor genes in the development of human cancer cells, we looked for the presence of mutations in LPA receptor 1-6 (LPA1-6) genes in MG63 osteosarcoma, HT1080 fibrosarcoma, A549 lung adenocarcinoma, MCF-7 breast carcinoma, ..
  75. Jethwa S, Leah E, Zhang Q, Bright N, Oxley D, Bootman M, et al. Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells. J Cell Sci. 2016;129:3948-3957 pubmed
    ..receptors of LPA; inhibition of signalling by the receptor antagonist Ki1642 suggests that these receptors are LPAR1 and LPAR3...
  76. Waśniewski T, Woclawek Potocka I, Boruszewska D, Kowalczyk Zieba I, Sinderewicz E, Grycmacher K. The significance of the altered expression of lysophosphatidic acid receptors, autotaxin and phospholipase A2 as the potential biomarkers in type 1 endometrial cancer biology. Oncol Rep. 2015;34:2760-7 pubmed publisher
    ..We investigated LPAR1, LPAR2, LPAR3, LPAR4, ATX and PLA2 expression at mRNA and protein levels using quantitative real-time PCR and ..
  77. Waters C, Saatian B, Moughal N, Zhao Y, Tigyi G, Natarajan V, et al. Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. Biochem J. 2006;398:55-62 pubmed
    We show that LPA1 (lysophosphatidic acid receptor-1) is constitutively localized in the nucleus of mammalian cells. LPA1 also traffics from cell membranes to the nucleus in response to LPA (lysophosphatidic acid)...
  78. Omotuyi O, Nagai J, Ueda H. Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation. Sci Rep. 2015;5:13343 pubmed publisher
    Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species...
  79. Ward Y, Lake R, Yin J, Heger C, Raffeld M, Goldsmith P, et al. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells. Cancer Res. 2011;71:7301-11 pubmed publisher
    ..CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enhanced LPA-dependent RHO and extracellular signal-regulated kinase activation...
  80. Waśniewski T, Woclawek Potocka I. Altered expression of lysophosphatidic acid receptors, in association with the synthesis of estrogens and androgens in type 1 endometrial cancer biology. Gynecol Endocrinol. 2017;:1-6 pubmed publisher
    To establish association between two main lysophosphatidic acid (LPA) receptors (LPAR2 and LPAR1) with the synthesis of estrogens and androgens in type-1 endometrial carcinoma (EC), we evaluated correlation of LPARs expression with ..
  81. Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, et al. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact. Cell Rep. 2017;20:2072-2086 pubmed publisher
    ..Six different G protein-coupled receptors have been identified as LPA receptors (LPA1-6). In studies using mutant mice, we found that LPA4 is involved in vascular network formation...
  82. Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, et al. Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J Biol Chem. 2011;286:43972-83 pubmed publisher
    ..with diverse biological functions, most of which are mediated by G protein-coupled receptors specific to LPA (LPA1-6)...
  83. Park S, Lee K, Kang S, Chung H, Bae Y, Okajima F, et al. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells. Cell Signal. 2013;25:2147-54 pubmed publisher
    ..Furthermore, VPC32183 and Ki16425 (antagonists of LPA1 and LPA3) inhibited LPE-induced [Ca(2+)]i increases, and knockdown of LPA1 by transfection with LPA1 siRNA ..
  84. Mototani H, Iida A, Nakajima M, Furuichi T, Miyamoto Y, Tsunoda T, et al. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Hum Mol Genet. 2008;17:1790-7 pubmed publisher
    ..Through the stepwise association study, an SNP located in the promoter region of EDG2 [endothelial differentiation, lysophosphatidic acid (LPA) GPCR, 2] (-2,820G/A; rs10980705) showed significant ..
  85. Wirtwein M, Melander O, Sjögren M, Hoffmann M, Narkiewicz K, Gruchala M, et al. Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease. Blood Press. 2017;26:174-180 pubmed publisher
    ..16-0.31, p?<?0.01). In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18. ..
  86. Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, et al. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res. 2008;103:662-70 pubmed publisher
    ..D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein-coupled receptors 1 (LPA1) and 2 (LPA2)...
  87. Zeng Y, Kakehi Y, Nouh M, Tsunemori H, Sugimoto M, Wu X. Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia. Prostate. 2009;69:283-92 pubmed publisher
    ..mRNA levels of three LPA receptors, LPA1, LPA2, LPA3, two LPA-synthesizing enzymes, autotaxin (ATX), acylglycerol kinase (AGK), and a LPA-degradation enzyme,..
  88. Liao Y, Mu G, Zhang L, Zhou W, Zhang J, Yu H. Lysophosphatidic acid stimulates activation of focal adhesion kinase and paxillin and promotes cell motility, via LPA1-3, in human pancreatic cancer. Dig Dis Sci. 2013;58:3524-33 pubmed publisher
    ..This study examined the involvement of LPA1-3 in LPA-induced activation of FAK and paxillin, and in cell motility, in pancreatic cancer PANC-1 cells...
  89. Murph M, Scaccia L, Volpicelli L, Radhakrishna H. Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. J Cell Sci. 2003;116:1969-80 pubmed
    ..range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA1/EDG-2, LPA2/EDG-4 and LPA3/EDG-7. Of these receptors, the LPA1 receptor is the most widely expressed...
  90. Zhao J, Wei J, Dong S, Bowser R, Zhang L, Jacko A, et al. Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury. EBioMedicine. 2016;10:195-203 pubmed publisher
    b>Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases...
  91. Xu K, Ma L, Li Y, Wang F, Zheng G, Sun Z, et al. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension. Hypertension. 2015;66:641-6 pubmed publisher
    ..by genotyping 28 single-nucleotide polymorphisms from genes encoding for lysophosphatidic acid receptors, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6 and their flanking sequences, in 3 Han Chinese cohorts consisting of 2630 ..
  92. Kanehira M, Fujiwara T, Nakajima S, Okitsu Y, Onishi Y, Fukuhara N, et al. An Lysophosphatidic Acid Receptors 1 and 3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells and Promotes Growth and Vascularization of Multiple Myeloma. Stem Cells. 2017;35:739-753 pubmed publisher
    ..myeloma cells stimulate MSCs to produce autotaxin, an indispensable enzyme for the biosynthesis of LPA, and LPA receptor 1 (LPA1) and 3 (LPA3) transduce opposite signals to MSCs to determine the fate of MSCs...