LOXL3

Summary

Gene Symbol: LOXL3
Description: lysyl oxidase like 3
Alias: LOXL, lysyl oxidase homolog 3, lysyl oxidase-like protein 3
Species: human
Products:     LOXL3

Top Publications

  1. Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, et al. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. Hum Genet. 2007;121:377-87 pubmed
    Four lysyl oxidase family genes (LOXL1, LOXL2, LOXL3, and LOXL4), which catalyze cross-linking of collagen and elastin, were considered to be functional candidates for intracranial aneurysms (IA) and were extensively screened for genetic ..
  2. Kasashima H, Yashiro M, Okuno T, Miki Y, Kitayama K, Masuda G, et al. Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer. Digestion. 2018;98:238-248 pubmed publisher
    ..The aim of this study was to analyze the LOX-like (LOXL)1, LOXL3, and LOXL4 expressions in gastric cancer tissue by immunohistochemical staining...
  3. Kumar P, Smith T, Raeman R, Chopyk D, Brink H, Liu Y, et al. Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells. J Biol Chem. 2018;293:12781-12792 pubmed publisher
    ..significantly increases the expression levels and activities of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) isoforms 1-3...
  4. Hajdú I, Kardos J, Major B, Fabó G, Lorincz Z, Cseh S, et al. Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett. 2018;28:3113-3118 pubmed publisher
    ..Potential inhibitors were also identified for LOX-like-protein-3 (LOXL3) and LOX-like-protein-4 (LOXL4), that are considered as emerging drug targets in the therapy of melanoma and ..
  5. Han X, Zhang X, Liu K, Zhang Q. Apelin-13 deficiency alters cortical bone geometry, organic bone matrix, and inhibits Wnt/β-catenin signaling. Gen Comp Endocrinol. 2018;267:29-35 pubmed publisher
    ..Deficiency of Apelin-13 downregulated collagen maturation associated genes (loxl3 and loxl4) and Wnt/β-catenin signaling, while loxl2 was upregulated, all of which indicated that Apelin-13 could ..
  6. Pappritz K, Savvatis K, Koschel A, Miteva K, Tschöpe C, Van Linthout S. Cardiac (myo)fibroblasts modulate the migration of monocyte subsets. Sci Rep. 2018;8:5575 pubmed publisher
    ..by lower collagen I, III, α-smooth muscle actin (α-SMA), lysyl oxidase (Lox)-1 and lysyl oxidase-like (LoxL)-2 levels in TGF-β1 + IFN-γ- versus TGF-ß1-stimulated cardiac fibroblasts...
  7. Lan W, Li X, Chen W, Liu C, Rong S, He R. [Gene expression of down-regulation of lysyl oxidases family in keratoconus corneal fibroblasts induced by combination of mechanical stretching and prostaglandin E 2]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017;34:239-245 pubmed publisher
    ..Compared to the static control group, 12% stretching alone up-regulated gene expression of LOXL-2, LOXL-4 in the healthy group, whereas it down-regulated LOXL-3, LOXL-4 in the keratoconus group...
  8. Pérez Rico C, Pascual G, Sotomayor S, Asúnsolo Ã, Cifuentes A, García Honduvilla N, et al. Elastin development-associated extracellular matrix constituents of subepithelial connective tissue in human pterygium. Invest Ophthalmol Vis Sci. 2014;55:6309-18 pubmed publisher
    ..Tissue was subjected to immunohistochemical staining with anti-lysyl oxidase (LOX), lyxyl oxidase-like 1 (LOXL-1), fibulin (FBLN)-5 and FBLN4, and fibrillin-1 (FBN1) antibodies...
  9. Huang Z, Du S, Huang L, Li J, Xiao L, Tong P. Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis. Osteoarthritis Cartilage. 2016;24:1246-53 pubmed publisher
    ..Lysyl oxidase-like 3 (LOXL3) mRNA expression in cartilage tissues and leptin concentration in joint synovial fluid (SF) was measured in ..

More Information

Publications46

  1. Dos Santos R, Pepicelli F, Batista N, de Carvalho C, Bortolini M, Castro R. Collagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse. Int Urogynecol J. 2018;29:893-898 pubmed publisher
    ..nucleotide polymorphisms (SNP) rs2236479 of the collagen 18 (COL18A1) and rs2862296 of the lysyl oxidase-like 4 (LOXL-4) genes and the association with pelvic organ prolapse (POP) in Brazilian women and determined risk factors for ..
  2. Xie Q, Xie J, Tian T, Ma Q, Zhang Q, Zhu B, et al. Hypoxia triggers angiogenesis by increasing expression of LOX genes in 3-D culture of ASCs and ECs. Exp Cell Res. 2017;352:157-163 pubmed publisher
    ..Semi-quantitative PCR was performed to quantify the mRNA expression of VEGFA, VEGFB, and the LOX genes (LOX, LOXL-1, LOXL-2, LOXL-3, and LOXL-4). Expression changes were determined by densitomery...
  3. Kraft Sheleg O, Zaffryar Eilot S, Genin O, Yaseen W, Soueid Baumgarten S, Kessler O, et al. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016;36:550-61 pubmed publisher
    ..We show that lysyl oxidase-like 3 (LoxL3) is a key regulator of integrin signaling that ensures localized control of the cascade...
  4. Nilsson M, Adamo H, Bergh A, Halin Bergström S. Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer. Sci Rep. 2016;6:19608 pubmed publisher
    Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibitory effects...
  5. Polettini J, Silva M, Kacerovsky M, Syed T, Saade G, Menon R. Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes. J Perinat Med. 2016;44:99-109 pubmed publisher
    ..02). LOX and LOXL1, 2 and 4 were localized to both amniotic and chorionic cells, whereas LOXL3 was limited to chorion...
  6. López Luppo M, Nacher V, Ramos D, Catita J, Navarro M, Carretero A, et al. Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging. Invest Ophthalmol Vis Sci. 2017;58:1116-1131 pubmed publisher
    ..This was parallel to enhanced lysyl oxidase-like (LOXL) 2 and 4 expression...
  7. Chan N, Willis A, Kornhauser N, Ward M, Lee S, Nackos E, et al. Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases. Clin Cancer Res. 2017;23:666-676 pubmed publisher
    ..7%). Lower Cp levels correlated with reduced EPCs (P = 0.002) and LOXL-2 (P < 0.001). Two-year EFS for patients with stage II-III and stage IV NED was 91% and 67%, respectively...
  8. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse. Reprod Sci. 2016;23:931-43 pubmed publisher
    ..and TIMP2) as well as genes involved in the biogenesis and maturation of collagen and elastin fibers (LOX, LOXL1-LOXL3, BMP1, and ADAMTS2) were significantly downregulated in POP-HVCs versus control-HVCs (P < .05)...
  9. Wu L, Zhu Y. The function and mechanisms of action of LOXL2 in cancer (Review). Int J Mol Med. 2015;36:1200-4 pubmed publisher
    ..Among these, at present, LOX‑like (LOXL)2 is the prototypical LOX and the most comprehensively studied member...
  10. Du J, Hincke M, Rose Martel M, Hennequet Antier C, Brionne A, Cogburn L, et al. Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics. BMC Genomics. 2015;16:792 pubmed publisher
    ..Genes encoding collagen-processing enzymes such as lysyl oxidase homologs 1, 2 and 3 (LOXL1, LOXL2 and LOXL3), prolyl 4 hydroxylase subunit α-2 and beta polypeptide (P4HA2 and P4HB) as well as peptidyl-prolyl cis-trans ..
  11. Sharma Bhandari A, Park S, Kim J, Oh J, Kim Y. Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells. Int J Mol Med. 2015;36:1664-70 pubmed publisher
    ..Thus far, five LOX family genes [LOX, lysyl oxidase-like (LOXL)1, LOXL2, LOXL3 and LOXL4] have been identified in humans, each encoding the characteristic C-terminal domains that are required ..
  12. Dudakova L, Sasaki T, Liskova P, Palos M, Jirsova K. The presence of lysyl oxidase-like enzymes in human control and keratoconic corneas. Histol Histopathol. 2016;31:63-71 pubmed publisher
    ..b>LOXL3 IHC staining was lower in the corneal stromal extracellular matrix and keratocytes of KC samples...
  13. Ritelli M, Chiarelli N, Zoppi N, Dordoni C, Quinzani S, Traversa M, et al. Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novel B3GALT6 mutations. Mol Genet Metab Rep. 2015;2:1-15 pubmed publisher
    ..enzymes involved in GAG synthesis and in ECM remodeling, such as CSGALNACT1, CHPF, LOXL3, and STEAP4, signaling transduction molecules of the TGF?/BMP pathway, i.e...
  14. Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, et al. Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016;6:33856 pubmed publisher
    Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development...
  15. Miana M, Galán M, Martínez Martínez E, Varona S, Jurado López R, Bausa Miranda B, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015;8:543-51 pubmed publisher
    ..The lysyl oxidase (LOX) family of amine oxidases, including LOX and LOX-like (LOXL) isoenzymes, controls ECM maturation, and upregulation of LOX activity is essential in fibrosis; however, its ..
  16. Insua Y, Cámara J, Vázquez E, Fernández A, Rivera F, Silva M, et al. Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study. Int J Mol Sci. 2017;18: pubmed publisher
    ..validate a gene expression panel (composed of GAPDH, VIL1, CLU, TIMP1, TLN1, LOXL3 and ZEB2) for detecting circulating tumor cells (CTCs) as prognostic and predictive tool in blood ..
  17. Zhang J, Yang R, Liu Z, Hou C, Zong W, Zhang A, et al. Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Hum Mol Genet. 2015;24:6174-85 pubmed publisher
    ..In this study, we investigated the essential role of lysyl oxidase-like 3 (LOXL3), a member of the LOX family, in embryonic development...
  18. Aumiller V, Strobel B, Romeike M, Schuler M, Stierstorfer B, Kreuz S. Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis. Sci Rep. 2017;7:149 pubmed publisher
    ..Using siRNA experiments we observed that LOXL2 and LOXL3 were crucial for fibroblast-to-myofibroblast transition (FMT)...
  19. Santamaria P, Floristán A, Fontanals Cirera B, Vázquez Naharro A, Santos V, Morales S, et al. Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Cell Death Differ. 2018;25:935-950 pubmed publisher
    Lysyl oxidase-like 3 (LOXL3) is a member of the lysyl oxidase family comprising multifunctional enzymes with depicted roles in extracellular matrix maturation, tumorigenesis, and metastasis...
  20. Li J, Gao B, Xiao X, Li S, Jia X, Sun W, et al. Exome sequencing identified null mutations in LOXL3 associated with early-onset high myopia. Mol Vis. 2016;22:161-7 pubmed
    ..L14Afs*21) and a compound heterozygous frameshift mutation (c.39dup; p.L14Afs*21 and c.594delG; p.Q199Kfs*35) in LOXL3 were separately identified in two of the 298 probands with early-onset high myopia...
  21. Philp C, Siebeke I, Clements D, Miller S, Habgood A, John A, et al. ECM Crosslinking Enhances Fibroblast Growth and Protects Against Matrix Proteolysis in Lung Fibrosis. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..Fibroblasts grown on IPF ECM had higher LOXL3 protein expression and transglutaminase activity compared with those grown on control ECM...
  22. Huang Y, Dai J, Tang R, Zhao W, Zhou Z, Wang W, et al. Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3). Matrix Biol. 2001;20:153-7 pubmed
    Using the PCR primers generated from human expressed sequence tag (EST), the cDNA of lysyl oxidase-like gene 3 (LOXL3), a new member of human lysyl oxidases gene family, was cloned from the human fetal brain mRNA...
  23. McGregor T, Gurnett C, Dobbs M, Wise C, Morcuende J, Morgan T, et al. Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype. BMC Med Genet. 2011;12:92 pubmed publisher
    ..We hypothesized that common polymorphisms in the five human lysyl oxidase genes (LOX, LOXL1, LOXL2, LOXL3, and LOXL4) may be associated with the phenotype of adolescent idiopathic scoliosis...
  24. Xie J, Wang C, Huang D, Zhang Y, Xu J, Kolesnikov S, et al. TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. J Biomech. 2013;46:890-8 pubmed publisher
    ..85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4)...
  25. Lee J, Kim Y. A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity. J Biol Chem. 2006;281:37282-90 pubmed
    The human lysyl oxidase-like 3 (LOXL3) encodes a member of the emerging family of lysyl oxidase (LOX) that functions as a copper-dependent amine oxidase...
  26. Peinado H, Del Carmen Iglesias de la Cruz M, Olmeda D, Csiszar K, Fong K, Vega S, et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 2005;24:3446-58 pubmed
    ..Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-cadherin ..
  27. Kim Y, Roh S, Park J, Kim Y, Cho D, Kim J. Differential expression of the LOX family genes in human colorectal adenocarcinomas. Oncol Rep. 2009;22:799-804 pubmed
    ..Recently, four paralogues (LOXL, LOXL2, LOXL3 and LOXL4) of LOX have been identified in humans, each containing the functional domains required for the amine ..
  28. Pacheco Costa R, Kadakia J, Atkinson E, Wallace J, Plotkin L, Reginato R. Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/?-catenin signaling. Bone. 2017;97:105-113 pubmed publisher
    ..Deletion of Cx37 increased genes involved in collagen maturation (loxl3 and loxl4) and glycosaminoglycans- (chsy1, chpf and has3) proteoglycans- associated genes (biglycan and decorin)...
  29. Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol. 2001;70:1-32 pubmed
    ..LOX) and our recent discovery of three novel members of this amine oxidase family, LOX-like (LOXL), LOXL2, and LOXL3, indicate the possibility that these varied functions are performed in both intracellular and extracellular ..
  30. Alzahrani F, Al Hazzaa S, Tayeb H, Alkuraya F. LOXL3, encoding lysyl oxidase-like 3, is mutated in a family with autosomal recessive Stickler syndrome. Hum Genet. 2015;134:451-3 pubmed publisher
    ..autosomal recessive forms of SS, we combined autozygome and exome analysis to identify a novel missense variant in LOXL3 as the likely candidate cause...
  31. Ma L, Huang C, Wang X, Xin D, Wang L, Zou Q, et al. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017;65:296-309 pubmed publisher
    ..LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites...
  32. Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
    ..and elevated expression levels of genes affecting tumor cell-extracellular matrix interaction, including loxl3, itga2b, itga3, and itga5...
  33. Mäki J, Kivirikko K. Cloning and characterization of a fourth human lysyl oxidase isoenzyme. Biochem J. 2001;355:381-7 pubmed
    ..Recombinant LOXL3, expressed in HT-1080 cells, was secreted into the culture medium but was not detected by immunofluorescence ..
  34. Molnar J, Fong K, He Q, Hayashi K, Kim Y, Fong S, et al. Structural and functional diversity of lysyl oxidase and the LOX-like proteins. Biochim Biophys Acta. 2003;1647:220-4 pubmed
    Lysyl oxidase (LOX) and four lysyl oxidase-like proteins, LOXL, LOXL2, LOXL3 and LOXL4, each contain a copper binding site, conserved lysyl and tyrosyl residues that may contribute to quinone co-factor formation, and a cytokine receptor-..
  35. Jourdan Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001;74:211-8 pubmed
    ..search of the human EST database indicated the presence of ESTs, corresponding to alternative splice variants of LOXL3, that lacked exon 5 and exon 8...
  36. Chen J, Ren J, Loo W, Hao L, Wang M. Lysyl oxidases expression and histopathological changes of the diabetic rat nephron. Mol Med Rep. 2017;: pubmed publisher
    ..tissue in the diabetic group were significantly higher compared with those of the control group, but LOXL1 and LOXL3 expression levels were not significantly different between the two groups...
  37. Sebban S, Davidson B, Reich R. Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. Virchows Arch. 2009;454:71-9 pubmed publisher
    Lysyl oxidase-like enzymes (LOXL) are expressed in various cancers. We analyzed the expression of LOXL2, LOXL3, and LOXL4 in cancers involving the serosal cavities-breast carcinoma, ovarian carcinoma, and malignant mesothelioma using ..