LOXL1

Summary

Gene Symbol: LOXL1
Description: lysyl oxidase like 1
Alias: LOL, LOXL, lysyl oxidase homolog 1, lysyl oxidase-like protein 1
Species: human
Products:     LOXL1

Top Publications

  1. Jung S, Kim M, Seo J, Kim H, Kim Y. Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies. Protein Expr Purif. 2003;31:240-6 pubmed
    ..cloning has revealed the existence of a LOX family consisting of LOX and four lysyl oxidase-like proteins (LOXLs; LOXL, LOXL2, LOXL3, and LOXL4)...
  2. Fan B, Pasquale L, Rhee D, Li T, Haines J, Wiggs J. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Invest Ophthalmol Vis Sci. 2011;52:2372-8 pubmed publisher
    b>LOXL1 is a major genetic risk factor for exfoliation syndrome (ES) and exfoliation glaucoma (EG)...
  3. Lee K, Ho S, Thalamuthu A, Venkatraman A, Venkataraman D, Pek D, et al. Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese. Mol Vis. 2009;15:1120-6 pubmed
    Single nucleotide polymorphisms (SNPs) within the lysyl oxidase like-1 gene (LOXL1; rs1048661 and rs3825942) were found to confer risk to pseudoexfoliation glaucoma (XFG) through the pseudoexfoliation syndrome (XFS) in Nordic, Caucasian, ..
  4. Hewitt A, Sharma S, Burdon K, Wang J, Baird P, Dimasi D, et al. Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people. Hum Mol Genet. 2008;17:710-6 pubmed
    ..We investigated the role of lysyl oxidase-like 1(LOXL1) sequence variation in a Caucasian Australian population-based cohort of 2508 individuals, 86 (3...
  5. Mossbock G, Renner W, Faschinger C, Schmut O, Wedrich A, Weger M. Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population. Mol Vis. 2008;14:857-61 pubmed
    ..two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated ..
  6. Schlötzer Schrehardt U, Hammer C, Krysta A, Hofmann Rummelt C, Pasutto F, Sasaki T, et al. LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma. Ophthalmology. 2012;119:1832-43 pubmed publisher
    To test the hypothesis that a primary disturbance in lysyl oxidase-like 1 (LOXL1) and elastin metabolism in the lamina cribrosa of eyes with pseudoexfoliation syndrome constitutes an independent risk factor for glaucoma development and ..
  7. Kim Y, Boyd C, Csiszar K. A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase. J Biol Chem. 1995;270:7176-82 pubmed
    ..It appears therefore that the genes encoding lysyl oxidase and a lysyl oxidase-like protein share a common evolutionary origin and may also be functionally related. ..
  8. Wolf C, Gramer E, Muller Myhsok B, Pasutto F, Gramer G, Wissinger B, et al. Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma. J Glaucoma. 2010;19:136-41 pubmed publisher
    To evaluate the association between lysyl-oxidase-like 1 (LOXL1) gene polymorphisms and exfoliation glaucoma, pigmentary glaucoma and normal tension glaucoma in a case-control cohort of German patients.
  9. Williams S, Whigham B, Liu Y, Carmichael T, Qin X, Schmidt S, et al. Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population. Mol Vis. 2010;16:705-12 pubmed
    To investigate whether variants in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) in an ancestral population from South Africa.

More Information

Publications68

  1. Tanito M, Minami M, Akahori M, Kaidzu S, Takai Y, Ohira A, et al. LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. Mol Vis. 2008;14:1898-905 pubmed
    To evaluate the association of lysyl oxidase like 1 (LOXL1) gene variants in Japanese patients with open-angle glaucoma.
  2. Rao K, Ritch R, Dorairaj S, Kaur I, Liebmann J, Thomas R, et al. Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma. Mol Vis. 2008;14:1254-62 pubmed
    Single nucleotide polymorphisms (SNPs) in the LOXL1 gene have been implicated in exfoliation syndrome (XFS) and exfoliation glaucoma (XFG)...
  3. Rautenbach R, Bardien S, Harvey J, Ziskind A. An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome. Arch Ophthalmol. 2011;129:206-10 pubmed publisher
    To investigate the association between 2 lysyl oxidase-like 1 (LOXL1) polymorphisms, rs1048661 (R141L) and rs3825942 (G153D), and exfoliation syndrome (XFS) in black South African individuals.
  4. Chakrabarti S, Rao K, Kaur I, Parikh R, Mandal A, Chandrasekhar G, et al. The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. Invest Ophthalmol Vis Sci. 2008;49:2343-7 pubmed publisher
    ..Recently, single nucleotide polymorphisms (SNPs) in the LOXL1 gene have been implicated in exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) but not in the primary ..
  5. Park D, Won H, Cho H, Kee C. Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population. Mol Vis. 2013;19:448-53 pubmed
    The purpose of this study was to evaluate association profiles of lysyl oxidase-like 1 (LOXL1) gene polymorphisms with pseudoexfoliation syndrome (XFS) in a Korean population...
  6. Damji K. Progress in understanding pseudoexfoliation syndrome and pseudoexfoliation-associated glaucoma. Can J Ophthalmol. 2007;42:657-8 pubmed
  7. Kenyon K, Modi W, Contente S, Friedman R. A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. J Biol Chem. 1993;268:18435-7 pubmed
    ..M. (1993) Genomics 16, 395-400). This lysyl oxidase-like gene, which appears to be no larger than 22.1 kilobases, codes for a single polyadenylated RNA species of 2.48 kilobases and has been mapped to chromosome 15q24-q25. ..
  8. Guadarrama Vallejo D, Miranda Duarte A, Zenteno J. The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction. Mol Vis. 2013;19:1937-44 pubmed
    Two coding single nucleotide polymorphisms (SNPs) in lysyl oxidase-like 1 (LOXL1) are major genetic risk factors for pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) in diverse populations...
  9. Liu Y, Schmidt S, Qin X, Gibson J, Hutchins K, Santiago Turla C, et al. Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations. Invest Ophthalmol Vis Sci. 2008;49:3465-8 pubmed publisher
    ..XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1)...
  10. Kagan H, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88:660-72 pubmed
    ..Recent studies have demonstrated that LO appears to function within the cell in a manner, which strongly modifies cellular activity. Newly discovered LO-like proteins also likely play unique roles in biology. ..
  11. Schlötzer Schrehardt U, Pasutto F, Sommer P, Hornstra I, Kruse F, Naumann G, et al. Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients. Am J Pathol. 2008;173:1724-35 pubmed publisher
    ..Two single nucleotide polymorphisms in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661 and rs3825942) have been recently identified as strong genetic risk factors for both PEX syndrome ..
  12. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer J, et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004;36:178-82 pubmed
    ..Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged ..
  13. Ferrell G, Lu M, Stoddard P, Sammel M, Romero R, Strauss J, et al. A single nucleotide polymorphism in the promoter of the LOXL1 gene and its relationship to pelvic organ prolapse and preterm premature rupture of membranes. Reprod Sci. 2009;16:438-46 pubmed publisher
    ..We identified a new single nucleotide polymorphism (NT_010194(LOXL1):g.45008784A>C) in the promoter of the LOXL1 gene, which is essential for elastin synthesis...
  14. Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S. Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome. Mol Vis. 2008;14:1303-8 pubmed
    To assess whether lysyl oxidase-like 1 (LOXL1) polymorphisms are associated with primary open-angle glaucoma (POAG) and exfoliation syndrome (XFS).
  15. Malukiewicz G, Lesiewska Junk H, Linkowska K, Mielnik M, Grzybowski T, Sulima N. Analysis of LOXL1 single nucleotide polymorphisms in Polish population with pseudoexfoliation syndrome. Acta Ophthalmol. 2011;89:e64-6 pubmed publisher
    To assess the possible association of lysyl oxidase-like 1 (LOXL1) gene variants with pseudoexfoliation syndrome (PEX) in Polish population.
  16. Kuhlenbaumer G, Friedrichs F, Kis B, Berlit P, Maintz D, Nassenstein I, et al. Association between single nucleotide polymorphisms in the lysyl oxidase-like 1 gene and spontaneous cervical artery dissection. Cerebrovasc Dis. 2007;24:343-8 pubmed
    ..with sCAD has been mapped to chromosome 15q24 to a candidate region containing the lysyl oxidase-like 1 gene (LOXL1)...
  17. Chen L, Jia L, Wang N, Tang G, Zhang C, Fan S, et al. Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population. Mol Vis. 2009;15:2349-57 pubmed
    To evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in a Chinese population.
  18. Pasutto F, Krumbiegel M, Mardin C, Paoli D, Lämmer R, Weber B, et al. Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 2008;49:1459-63 pubmed publisher
    Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with both pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from Iceland and Sweden...
  19. Ramprasad V, George R, Soumittra N, Sharmila F, Vijaya L, Kumaramanickavel G. Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India. Mol Vis. 2008;14:318-22 pubmed
    ..pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) has been significantly associated with LOXL1 exon 1 polymorphisms - allele G of rs1048661 (R141L) and allele G of rs3825942 (G135D)...
  20. Zenkel M, Krysta A, Pasutto F, Juenemann A, Kruse F, Schlötzer Schrehardt U. Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci. 2011;52:8488-95 pubmed publisher
    ..Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodulating factors are necessary for the manifestation of the disease...
  21. Jaimes M, Rivera Parra D, Miranda Duarte A, Valdés G, Zenteno J. Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population. Ophthalmic Genet. 2012;33:12-7 pubmed publisher
    ..A significant association exists between XFG and several SNPs in the lysyl oxidase-like 1 (LOXL1) gene...
  22. Kim S, Kim Y. Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity. Mol Vis. 2012;18:265-70 pubmed
    Lysyl oxidase-like 1 (LOXL1) is a copper-dependant amine oxidase that plays an essential role in elastogenesis...
  23. Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol. 2001;70:1-32 pubmed
    ..of lysyl oxidase (LOX) and our recent discovery of three novel members of this amine oxidase family, LOX-like (LOXL), LOXL2, and LOXL3, indicate the possibility that these varied functions are performed in both intracellular and ..
  24. Chiras D, Tzika K, Kokotas H, Oliveira S, Grigoriadou M, Kastania A, et al. Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population. Mol Vis. 2013;19:1006-16 pubmed
    ..In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate ..
  25. Chen H, Chen L, Zhang M, Gong W, Tam P, Lam D, et al. Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma. Mol Vis. 2010;16:167-77 pubmed
    To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma.
  26. Zanon Moreno V, Zanon Moreno L, Ortega Azorín C, Asensio Marquez E, Garcia Medina J, Sanz P, et al. Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk. Clin Exp Ophthalmol. 2015;43:26-30 pubmed publisher
    To investigate the possible association of the rs2165241 polymorphism (C > T) in LOXL1 gene with the risk of primary open-angle glaucoma in a Mediterranean population...
  27. Khan T, Li G, Navarro I, Kastury R, Zeil C, Semchyshyn T, et al. LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma. Mol Vis. 2010;16:2236-41 pubmed
    To study lysyl oxidase-like 1 (LOXL1) expression in freshly collected lens capsules from pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and normal cataract control individuals...
  28. Kasım B, Irkec M, Alikasifoglu M, Orhan M, Mocan M, Aktas D. Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population. Mol Vis. 2013;19:114-20 pubmed
    To investigate the association of lysyl oxidase like 1 (LOXL1) variants with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), and primary open angle glaucoma (POAG) in a Turkish population.
  29. Mayinu -, Chen X. Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population. Mol Vis. 2011;17:1734-44 pubmed
    ..In this study, we evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with XFS in the Uygur population...
  30. Micheal S, Khan M, Akhtar F, Ali M, Ahmed A, den Hollander A, et al. Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma. Mol Vis. 2012;18:1040-4 pubmed
    Single nucleotide polymorphisms (SNPs) rs1048661 (p.R141L) and rs3825942 (p.G153D) in the lysyl oxidase-like 1 (LOXL1) gene have been previously reported to be associated with pseudoexfoliation glaucoma (PEXG) in various Asian and ..
  31. Liu Y, Whigham B, Wheeler J, Williams S, Rautenbach R, Ziskind A, et al. The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma. Mol Vis. 2012;18:2976-81 pubmed
    To investigate whether DNA copy number variants (CNVs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) in black South Africans.
  32. Mori K, Imai K, Matsuda A, Ikeda Y, Naruse S, Hitora Takeshita H, et al. LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population. Mol Vis. 2008;14:1037-40 pubmed
    ..studies using a native Japanese population to examine the reproducibility of results of lysyl oxidase-like 1 (LOXL1) genetic association studies for exfoliation glaucoma (XFG) beyond the differences of ethnicity...
  33. Ritch R. Exfoliation syndrome: beyond glaucoma. Arch Ophthalmol. 2008;126:859-61 pubmed publisher
  34. Ozaki M, Lee K, Vithana E, Yong V, Thalamuthu A, Mizoguchi T, et al. Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese. Invest Ophthalmol Vis Sci. 2008;49:3976-80 pubmed publisher
    The single nucleotide polymorphisms (SNPs) rs1048661, rs3825942, and rs2165241 within the LOXL1 gene were recently found to confer risk of pseudoexfoliation glaucoma (XFG) through pseudoexfoliation syndrome (XFS) in Caucasians...
  35. Fan B, Pasquale L, Grosskreutz C, Rhee D, Chen T, DeAngelis M, et al. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008;9:5 pubmed publisher
    ..Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with pseudoexfoliation in Nordic populations are significantly associated with ..
  36. Traboulsi E, Sarfarazi M. The use of microarray technology in deciphering the cause of genetic eye diseases: LOXL1 and exfoliation syndrome. Am J Ophthalmol. 2008;145:391-3 pubmed publisher
  37. Wiggs J. Association Between LOXL1 and pseudoexfoliation. Arch Ophthalmol. 2008;126:420-1 pubmed publisher
  38. Lemmelä S, Forsman E, Onkamo P, Nurmi H, Laivuori H, Kivela T, et al. Association of LOXL1 gene with Finnish exfoliation syndrome patients. J Hum Genet. 2009;54:289-97 pubmed publisher
    In this study, three single-nucleotide polymorphisms (SNPs) on the lysyl oxidase-like 1 (LOXL1) gene associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) were investigated in the Finnish population...
  39. Thomassin L, Werneck C, Broekelmann T, Gleyzal C, Hornstra I, Mecham R, et al. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem. 2005;280:42848-55 pubmed
    These studies were undertaken to determine how lysyl oxidase (LOX) and lysyl oxidase like-1 (LOXL) enzymes are targeted to their substrates in the extracellular matrix...
  40. Giardina E, Oddone F, Lepre T, Centofanti M, Peconi C, Tanga L, et al. Common sequence variants in the LOXL1 gene in pigment dispersion syndrome and pigmentary glaucoma. BMC Ophthalmol. 2014;14:52 pubmed publisher
    Single nucleotide polymorphisms (SNPs) within the LOXL1 gene are associated with pseudoesfoliation syndrome and pseudoesfoliation glaucoma...
  41. Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, et al. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. Hum Genet. 2007;121:377-87 pubmed
    Four lysyl oxidase family genes (LOXL1, LOXL2, LOXL3, and LOXL4), which catalyze cross-linking of collagen and elastin, were considered to be functional candidates for intracranial aneurysms (IA) and were extensively screened for genetic ..
  42. Metaxaki I, Constantoulakis P, Papadimitropoulos M, Filiou E, Georgopoulos G, Chamchougia A, et al. Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Mol Vis. 2013;19:1446-52 pubmed
    Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from various parts of the world...
  43. Thorleifsson G, Magnusson K, Sulem P, Walters G, Gudbjartsson D, Stefansson H, et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science. 2007;317:1397-400 pubmed
    ..Two nonsynonymous SNPs in exon 1 of the gene LOXL1 explain the association, and the data suggest that they confer risk of XFG mainly through exfoliation syndrome (..
  44. Fingert J, Alward W, Kwon Y, Wang K, Streb L, Sheffield V, et al. LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States. Am J Ophthalmol. 2007;144:974-975 pubmed
  45. Hayashi H, Gotoh N, Ueda Y, Nakanishi H, Yoshimura N. Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population. Am J Ophthalmol. 2008;145:582-585 pubmed publisher
    To investigate the contribution of two single-nucleotide polymorphisms (SNPs) of the lysyl oxidase-like 1 (LOXL1) gene, recently shown to be associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Nordic ..
  46. Sagong M, Gu B, Cha S. Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans. Mol Vis. 2011;17:2808-17 pubmed
    To evaluate the association of the lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) in the Korean population with exfoliation syndrome (XFS) and to investigate the association between the SNPs and phenotypes of XFS.
  47. Abramsson A, Landgren S, Zetterberg M, Seibt Palmér M, Minthon L, Gustafson D, et al. No association of LOXL1 gene polymorphisms with Alzheimer's disease. Neuromolecular Med. 2011;13:160-6 pubmed publisher
    ..The present study aimed at investigating the association of lysyl oxidase-like 1 (LOXL1) polymorphisms with AD diagnosis and cerebrospinal fluid biomarkers (CSF) for the disease...
  48. Abu Amero K, Osman E, Azad M, Allingham R, Hauser M, Al Obeidan S. Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population. Ophthalmic Genet. 2012;33:130-3 pubmed publisher
    To investigate whether major single nucleotide polymorphisms (SNPs) in the LOXL1 gene associated with pseudoexfoliation glaucoma are associated with primary open angle glaucoma (POAG) in the Saudi Arabian population...
  49. Fuse N, Mengkegale M, Miyazawa A, Abe T, Nakazawa T, Wakusawa R, et al. Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration. Am J Ophthalmol. 2011;151:550-6.e1 pubmed publisher
    To determine whether polymorphisms in the ARMS2 (LOC387715) gene and the lysyl oxidase-like 1 (LOXL1) gene are associated with age-related macular degeneration (AMD) in Japanese patients. Clinically relevant laboratory investigation...
  50. Abu Amero K, Osman E, Dewedar A, Schmidt S, Allingham R, Al Obeidan S. Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma. Mol Vis. 2010;16:2805-10 pubmed
    To investigate whether single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with pseudoexfoliation glaucoma (PEG) in the Saudi Arabian population...
  51. Hollo G, Gal A, Kóthy P, Molnár J. LOXL1 gene sequence variants and vascular disease in exfoliation syndrome and exfoliative glaucoma. J Glaucoma. 2011;20:143-7 pubmed publisher
    To investigate whether the single nucleotide polymorphisms (SNPs) of the LOXL1 gene associated with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) are different in XFS/XFG patients with and without cardiovascular disease (CVD);..
  52. Gong W, Chiang S, Chen L, Tam P, Jia L, Leung D, et al. Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese. Mol Vis. 2008;14:2381-9 pubmed
    The lysyl oxidase-like protein 1 (LOXL1) gene is strongly associated with exfoliation glaucoma, which is very rare in the Chinese population...
  53. Challa P. Genetics of pseudoexfoliation syndrome. Curr Opin Ophthalmol. 2009;20:88-91 pubmed publisher
    ..The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the study of this disorder...
  54. Jonasson F. From epidemiology to lysyl oxidase like one (LOXL1) polymorphisms discovery: phenotyping and genotyping exfoliation syndrome and exfoliation glaucoma in Iceland. Acta Ophthalmol. 2009;87:478-87 pubmed publisher
    ..single nucleotide polymorphisms (SNPs)] on a relatively small number of patients did discover that lysyl oxidase like 1 (LOXL1) on chromosome 15q24 is a major gene for XFS/XFG. These results have now largely been replicated world-wide.
  55. Challa P, Schmidt S, Liu Y, Qin X, Vann R, Gonzalez P, et al. Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma. Mol Vis. 2008;14:146-9 pubmed
    To identify if recently described LOXL1 (lysyl oxidase-like 1) polymorphisms are associated with pseudoexfoliation glaucoma (XFG) in a United States (U.S.) Caucasian patient population...
  56. Aragon Martin J, Ritch R, Liebmann J, O Brien C, Blaaow K, Mercieca F, et al. Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Mol Vis. 2008;14:533-41 pubmed
    To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients.
  57. Yang X, Zabriskie N, Hau V, Chen H, Tong Z, Gibbs D, et al. Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort. Cell Cycle. 2008;7:521-4 pubmed
    ..We investigated LOXL1 gene variants previously identified to confer susceptibility to XFG in a Utah Caucasian cohort...
  58. Pascual G, Mendieta C, Mecham R, Sommer P, Bellon J, Bujan J. Down-regulation of lysyl oxydase-like in aging and venous insufficiency. Histol Histopathol. 2008;23:179-86 pubmed publisher
    ..study was to examine the in vivo expression of the elastin precursor, tropoelastin (TE), and lysyl oxidase-like 1 (LOXL1), a cross-linking enzyme responsible for elastin polymer deposition...
  59. Fuse N, Miyazawa A, Nakazawa T, Mengkegale M, Otomo T, Nishida K. Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese. Mol Vis. 2008;14:1338-43 pubmed
    To investigate the lysyl oxidase-like 1 (LOXL1) gene for single nucleotide polymorphism (SNP) variations in Japanese patients with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) and to examine the phenotypes of the patients ..