Gene Symbol: LOC102724971
Description: putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
Alias: IGH, IGHV4, IGHV4-04, IGHV4-4, IGHV@, IGVH, IgA, V4-4b, ighv, Ig H-chain V-region (DP-69), Ig heavy chain gene variable region V(11), anti-ZIKV immunoglobulin heavy chain variable region, circulating B cell antibody heavy chain variable region, immunoglobulin alpha heavy chain variable region, immunoglobulin heavy chain CDR3, immunoglobulin heavy chain V region, immunoglobulin heavy chain VHDJ region, immunoglobulin heavy chain variable region, immunoglobulin mu heavy chain, immunoglobulin mu heavy chain variable region, immunoglobulin variable region, rotavirus-specific intestinal-homing antibody heavy chain variable region
Species: human

Top Publications

  1. Milili M, Le Deist F, de Saint Basile G, Fischer A, Fougereau M, Schiff C. Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire. J Clin Invest. 1993;91:1616-29 pubmed
  2. Kolar G, Yokota T, Rossi M, Nath S, Capra J. Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire. Blood. 2004;104:2981-7 pubmed
    ..From the standpoint of the Ig repertoire, an immune system reconstituted from fetal or neonatal stem cells would likely be as diverse as one generated from adult bone marrow. ..
  3. Weitkamp J, Kallewaard N, Bowen A, Lafleur B, Greenberg H, Crowe J. VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7. J Immunol. 2005;174:3454-60 pubmed
    ..Interestingly, RV-specific intestinal homing IgD-/alpha4beta7+ B cells using the VH1-46 gene segment were not mutated, in contrast to systemic RV-specific IgD- B cells. ..
  4. Tian C, Luskin G, Dischert K, Higginbotham J, Shepherd B, Crowe J. Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells. Mol Immunol. 2007;44:2173-83 pubmed
    ..These data suggest distinct functional mechanisms underlying selection of this unique subset of un-class-switched memory B cells. ..
  5. Bilous N, Bomben R, Dal Bo M, Capello D, Forconi F, Laurenti L, et al. Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort. Leuk Lymphoma. 2010;51:822-38 pubmed publisher
    ..homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection ..
  6. Tian C, Luskin G, Dischert K, Higginbotham J, Shepherd B, Crowe J. Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. J Immunol. 2008;180:3279-88 pubmed
    ..Increased diversity in the VH gene repertoire of the two memory B cell groups derived from broader usage of VH gene segments, increased junctional diversity that was introduced by differential TdT activities, and somatic hypermutation. ..
  7. Charles E, Green R, Marukian S, Talal A, Lake Bakaar G, Jacobson I, et al. Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia. Blood. 2008;111:1344-56 pubmed
    ..This study was registered at www.clinicaltrials.gov as NCT00219999. ..
  8. Abramenko I, Bilous N, Chumak A, Davidova E, Kryachok I, Martina Z, et al. Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident--with focus on immunoglobulin heavy chain gene analysis. Leuk Res. 2008;32:535-45 pubmed
    Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients...
  9. Zemlin M, Hoersch G, Zemlin C, Pohl Schickinger A, Hummel M, Berek C, et al. The postnatal maturation of the immunoglobulin heavy chain IgG repertoire in human preterm neonates is slower than in term neonates. J Immunol. 2007;178:1180-8 pubmed
    During the perinatal period the development of the IgH chain CDR3 (CDR-H3) repertoire of IgM transcripts is maturity-dependent and not influenced by premature exposure to Ag...

More Information


  1. Harindranath N, Goldfarb I, Ikematsu H, Burastero S, Wilder R, Notkins A, et al. Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient. Int Immunol. 1991;3:865-75 pubmed
  2. Weitkamp J, Lafleur B, Crowe J. Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells. Hum Immunol. 2006;67:33-42 pubmed
  3. Dono M, Zupo S, Leanza N, Melioli G, Fogli M, Melagrana A, et al. Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents. J Immunol. 2000;164:5596-604 pubmed
  4. Wang X, Stollar B. Immunoglobulin VH gene expression in human aging. Clin Immunol. 1999;93:132-42 pubmed
  5. Tschumper R, Geyer S, Campbell M, Kay N, Shanafelt T, Zent C, et al. Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients. J Clin Invest. 2008;118:306-15 pubmed
    ..Irrespective of IGHV usage, UM patients whose B-CLL cells expressed the IGHD3-3 gene had a significantly shorter TTT than other UM B-CLL ..
  6. Williams J, Weitkamp J, Blum D, Lafleur B, Crowe J. The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. Mol Immunol. 2009;47:407-14 pubmed publisher
    ..These biased features of the RSV-specific repertoire likely contribute to the poor functional Ab response in very young infants. ..
  7. Fischer P, Jendreyko N, Hoffmann M, Lerch H, Uttenreuther Fischer M, Chen P, et al. Platelet-reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia. Br J Haematol. 1999;105:626-40 pubmed
    ..Selected Fab-phages representing the characteristic variable regions that occurred in the investigated patients with AITP may now be used to clone potentially regulatory anti-idiotypes from healthy donors by phage display. ..
  8. Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, et al. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. Sci Transl Med. 2016;8:369ra179 pubmed
    ..Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines. ..