LOC101929667

Summary

Gene Symbol: LOC101929667

Description: uncharacterized LOC101929667

Species: human

Kim J, Hong K, Go M, Kim S, Tabara Y, Kita Y, et al. A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval. Am J Hum Genet. 2012;91:180-4 pubmed publisher

..500 has been reported in Asians (HapMap HCB [Han Chinese in Beijing, China] and JPT [Japanese in Tokyo, Japan] samples). This might explain why this locus has not been identified in Europeans in previous studies. ..
Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher

..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
Sano M, Kamitsuji S, Kamatani N, Hong K, Han B, Kim Y, et al. Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. Hum Mol Genet. 2014;23:6668-76 pubmed publisher

..Our findings support a functional role of sodium-calcium exchanger in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models. ..