LMO3

Summary

Gene Symbol: LMO3
Description: LIM domain only 3 (rhombotin-like 2)
Alias: RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only protein 3, neuronal-specific transcription factor DAT1, rhombotin-3
Species: human

Top Publications

  1. ncbi LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma
    Mineyoshi Aoyama
    Division of Biochemistry, Chiba Cancer Center Research Institute, Japan
    Cancer Res 65:4587-97. 2005
  2. pmc Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
    Hideo Watanabe
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:197-210. 2013
  3. doi Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorph
    David K Miller
    LifeStream Solutions, Inc, Prescott, AZ, USA
    Postgrad Med 122:188-213. 2010
  4. pmc Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 35:161-77. 2009
  5. ncbi High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD
    Emma M van der Meulen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Child Psychol Psychiatry 46:1074-80. 2005
  6. ncbi Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)
    Yu Feng
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 139:1-6. 2005
  7. doi Dopaminergic haplotype as a predictor of spatial inattention in children with attention-deficit/hyperactivity disorder
    Mark A Bellgrove
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072
    Arch Gen Psychiatry 66:1135-42. 2009
  8. doi Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008
  9. doi Molecular genetics of attention
    Mark A Bellgrove
    School of Psychology, University of Queensland, 4072 Queensland, Australia
    Ann N Y Acad Sci 1129:200-12. 2008
  10. pmc Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome
    T Sekizaki
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Bacteriol 183:500-11. 2001

Detail Information

Publications140 found, 100 shown here

  1. ncbi LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma
    Mineyoshi Aoyama
    Division of Biochemistry, Chiba Cancer Center Research Institute, Japan
    Cancer Res 65:4587-97. 2005
    LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination and differentiation during embryonic development...
  2. pmc Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
    Hideo Watanabe
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:197-210. 2013
    ..Integration of these expression and cistromic analyses identified LMO3, itself encoding a transcription regulator, as a candidate direct transcriptional target of NKX2-1...
  3. doi Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorph
    David K Miller
    LifeStream Solutions, Inc, Prescott, AZ, USA
    Postgrad Med 122:188-213. 2010
    ....
  4. pmc Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 35:161-77. 2009
    ..Pharmacogenetics uses genetic variation to predict individual differences in response to medications and holds much promise to improve treatment of addictive disorders...
  5. ncbi High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD
    Emma M van der Meulen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Child Psychol Psychiatry 46:1074-80. 2005
    ..This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles...
  6. ncbi Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)
    Yu Feng
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 139:1-6. 2005
    ..Our results therefore refute the possibility of the reported DraI variation or alleles of the VNTR as the functional variants contributing to the disorder...
  7. doi Dopaminergic haplotype as a predictor of spatial inattention in children with attention-deficit/hyperactivity disorder
    Mark A Bellgrove
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072
    Arch Gen Psychiatry 66:1135-42. 2009
    ..A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics...
  8. doi Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008
    ..015). This interaction might reflect the regulatory effect of COMT dominated prefrontal dopamine transmission on subcortical dopamine systems, which are the actual site of methylphenidate action...
  9. doi Molecular genetics of attention
    Mark A Bellgrove
    School of Psychology, University of Queensland, 4072 Queensland, Australia
    Ann N Y Acad Sci 1129:200-12. 2008
    ....
  10. pmc Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome
    T Sekizaki
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Bacteriol 183:500-11. 2001
    ..These results suggest that the SsuDAT1I system could have been integrated into the S. suis chromosome by an illegitimate recombination mechanism...
  11. ncbi Dopamine transporter gene associated with diminished subjective response to amphetamine
    David C Lott
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:602-9. 2005
    ..The current findings have important implications for understanding the genetic determinants of variability in stimulant response and risk of abuse...
  12. ncbi Pharmacogenetics of methylphenidate response in preschoolers with ADHD
    James McGough
    UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 45:1314-22. 2006
    ..The authors explored genetic moderators of symptom reduction and side effects in methylphenidate-treated preschool-age children diagnosed with attention-deficit/hyperactivity disorder (ADHD)...
  13. ncbi [Distribution of DRD4 and DAT1 alleles from dopaminergic system in a mixed Chilean population]
    Gonzalo Vieyra
    Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70061, Santiago 7, Chile
    Rev Med Chil 131:135-43. 2003
    ..7 (61%) than for DRD4.4 (29%). The ten repetition allele for DAT1 transporter has a high frequency among Europeans (72%) and Amerindians (100%). The allele DAT1*9 is the second most frequent allele...
  14. pmc Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients
    Zsofia Nemoda
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Behav Brain Funct 6:4. 2010
    ..However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD...
  15. doi [Combination of DRD4 and DAT1 genotypes is an important risk factor for attention deficit disorder with hyperactivity families living in Santiago, Chile]
    Hugo Henríquez B
    Centro de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Rev Med Chil 136:719-24. 2008
    ..Attention deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness...
  16. doi Case-control and within-family tests for an association between conduct disorder and DAT1
    R Jay Schulz-Heik
    Institute for Behavioral Genetics, Department of Psychology, University of Colorado, Boulder 80309, USA
    Psychiatr Genet 18:17-24. 2008
    ..Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children...
  17. doi Abnormal adenosine and dopamine receptor expression in lymphocytes of Lesch-Nyhan patients
    M G Garcia
    Divisions of Clinical Biochemistry and Internal Medicine, La Paz University Hospital, Madrid, Spain
    Brain Behav Immun 23:1125-31. 2009
    ....
  18. ncbi Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  19. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  20. doi The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation
    Pekka Santtila
    Center of Excellence in Behavior Genetics, Department of Psychology, Abo Akademi University, Turku, Finland
    J Sex Med 7:1538-46. 2010
    ..Previous research has suggested brain dopamine (DA) neurotransmission to be involved in the control of ejaculation. Furthermore, previous studies indicate a partly hereditary background to premature ejaculation...
  21. pmc Dopamine transporter gene variation modulates activation of striatum in youth with ADHD
    Anne Claude Bedard
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroimage 53:935-42. 2010
    ..These findings provide preliminary evidence that neural activity related to inhibitory control may differ as a function of DAT1 3'UTR genotype in youth with ADHD...
  22. ncbi Dopamine transporter, gender, and number of sexual partners among young adults
    Guang Guo
    Department of Sociology, University of North Carolina, Chapel Hill, NC 27599 3210, USA
    Eur J Hum Genet 15:279-87. 2007
    ..Discussion is provided why this finding is absent among females...
  23. doi Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder
    Edmund J S Sonuga-Barke
    Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, Southampton, UK
    J Child Psychol Psychiatry 50:1052-63. 2009
    ....
  24. ncbi Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3)
    Dustin Y Yoon
    Department of Neurology, Johns Hopkins University School of Medicine, Harriet Lane Children s Health Building, Wolfe Street, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:605-10. 2007
    ..Since abnormalities of the dopamine transporter have been hypothesized in the pathophysiology of TS, it is possible that this could be a functional allele associated with clinical expression...
  25. ncbi The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence
    Yann Le Strat
    INSERM U675, IFR02, Faculté de Médecine Xavier Bichat Université, Henri Huchard, Paris, France
    Alcohol Clin Exp Res 32:27-35. 2008
    ..We investigated whether polymorphisms within the DAT1 gene are associated with WS taking into account some of the confounding factors such as the severity of alcohol dependence...
  26. doi Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, NY 11794 8790, USA
    J Child Psychol Psychiatry 49:1331-8. 2008
    ....
  27. ncbi [Association analysis between polymorphism of dopamine transporter variable number tandem repeat and breast cancer with abnormal Hilit]
    Xiao Mei Peng
    College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China
    Zhonghua Yi Xue Za Zhi 90:515-8. 2010
    ..To explore the association between polymorphism of dopamine 1 transporter variable number tandem repeat (DAT1 VNTR) and breast cancer with abnormal Hilit in Chinese Han population from Xinjiang...
  28. pmc Eating disorders with binge-eating behaviour are associated with the s allele of the 3'-UTR VNTR polymorphism of the dopamine transporter gene
    Manabu Shinohara
    Department of Neuropsychiatry, Graduate School of Medicine and Engineering, The University of Yamanashi, Nakakoma, Japan
    J Psychiatry Neurosci 29:134-7. 2004
    ....
  29. pmc Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
    E E Forbes
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:60-70. 2009
    ..They further suggest that altered VS reactivity may represent a key neurobiological pathway through which these polymorphisms contribute to variability in behavioral impulsivity and related risk for substance use disorders...
  30. ncbi Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer
    Daniele Campa
    International Agency for Research on Cancer, Lyon, France
    Lung Cancer 56:17-23. 2007
    ..The bioavailability of dopamine is regulated by dopamine receptors D2 (DRD2), D4 (DRD4) and dopamine transporter 1 (DAT1/SLC6A3) genes...
  31. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ....
  32. ncbi Construction and characterization of Streptococcus suis-Escherichia coli shuttle cloning vectors
    D Takamatsu
    Laboratory of Molecular Bacteriology, National Institute of Animal Health, 3 1 1 Kannondai, Tsukuba, Ibaraki, 305 0856, Japan
    Plasmid 45:101-13. 2001
    ..suis but not in E. coli. These results showed that pSET vectors are useful tools for cloning and analyzing S. suis genes in S. suis strains directly...
  33. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
    ..Multi-gene profiles in specific individuals may be of assistance in choosing the appropriate treatment...
  34. ncbi Family-based association study of DAT1 and DRD4 polymorphism in Korean children with ADHD
    Young Shin Kim
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    Neurosci Lett 390:176-81. 2005
    ..Future studies are necessary to test the hypothesis generated in this study that the 5-repeat allele of DRD4 is protective for hyperactive-impulsivity symptom severity compared to the 4-repeat allele...
  35. ncbi Potent agonists of growth hormone-releasing hormone. II
    M Zarandi
    Veterans Affairs Medical Center, New Orleans, LA 70146
    Pept Res 5:190-3. 1992
    ....
  36. ncbi Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene
    Satoshi Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902
    J Biochem 137:205-16. 2005
    ..We also show that SNP of Hesr1, C386A, causes a lack of activity. These results suggest that Hesr1 and its polymorphism(s) might be involved in dopamine-related polygenic disorders and behavioral traits...
  37. ncbi Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3' UTR polymorphism of the dopamine transporter gene
    Zsanett Tarnok
    Vadaskert Child and Adolescent Psychiatric Clinic, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:900-5. 2007
    ..002). In summary, allele frequencies did not differ between cases and controls, but DAT1 genotype accounted for variations of tic severity within the TS group...
  38. doi Neither single-marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese
    Y W Yeh
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Genes Brain Behav 9:638-47. 2010
    ..This study suggests that the DAT1 gene may not contribute to the risk of HD and specific personality traits in HD among the Han Chinese population...
  39. pmc The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors
    Guang Guo
    Department of Sociology, The University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9352. 2010
    ..These comparisons indicate that the protective effect of DAT1*9R/9R cannot be explained away by these background characteristics. Our work demonstrates how legal/social contexts can enhance or reduce a genetic effect on risky behaviors...
  40. pmc Bacillus subtilis gene coding for constitutive O6-methylguanine-DNA alkyltransferase
    F Morohoshi
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Nucleic Acids Res 17:6531-43. 1989
    ..The dat-1 mutation was shown to be caused by a structural rearrangement affecting the coding region, and the 0.8 kb transcripts of this gene were detected in dat+ cells but not in dat mutant cells...
  41. pmc Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice
    E Tse
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 24:2063-73. 2004
    ..We have carried out gene targeting of the other members of the LIM-only family, viz., genes Lmo1, Lmo3 and Lmo4, to investigate their role in mouse development...
  42. pmc Association of attention-deficit disorder and the dopamine transporter gene
    E H Cook
    Department of Psychiatry, University of Chicago, IL, USA
    Am J Hum Genet 56:993-8. 1995
    ..Biochemical analysis of such mutations may lead to development of more effective therapeutic interventions...
  43. ncbi Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
    ..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
  44. ncbi Identification of novel genes regulated in the developing human ventral mesencephalon
    Jesper Roland Jørgensen
    NsGene A S, Baltorpvej 154, DK 2750 Ballerup, Denmark
    Exp Neurol 198:427-37. 2006
    ..The data presented here may help to device cell replacement and regenerative therapies for Parkinson's disease (PD)...
  45. ncbi [Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]
    M Wohl
    CHU Robert Debré AP HP, Paris VII, 75019 Paris
    Encephale 31:437-47. 2005
    ..In addition, the development of pharmacogenetics could help to identify predictors of clinical response for a specific type of treatment, which would be clearly helpful in clinical practice...
  46. ncbi Sequence analysis of a small cryptic plasmid isolated from Streptococcus suis serotype 2
    D Takamatsu
    National Institute of Animal Health, 3 1 1 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Curr Microbiol 40:61-6. 2000
    ..Moreover, a 5-amino acid conserved sequence was found in C terminal of Rep and putative Rep proteins of several pMV158 family plasmids. These observations suggest that this plasmid replicates by use of the rolling circle mechanism...
  47. ncbi DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  48. ncbi Dopamine transporter genotype and methylphenidate dose response in children with ADHD
    Mark A Stein
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:1374-82. 2005
    ..Further research is needed to determine the mechanisms related to poor response in patients with the 9/9-repeat genotype, and to determine if this group responds differentially to alternative treatments...
  49. pmc Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 31:210-21. 2010
    ..Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans...
  50. pmc Dopamine transporter genotype predicts implicit sequence learning
    Jessica R Simon
    Department of Psychology, Georgetown University, Washington, DC 20057, United States
    Behav Brain Res 216:452-7. 2011
    ....
  51. pmc 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system
    Suparna Sengupta
    Department of Biophysical Chemistry, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India
    Br J Pharmacol 145:1076-83. 2005
    ..It would also be an interesting probe for the structure-function studies of tubulin-microtubule system...
  52. ncbi Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes
    M Salkovic-Petrisic
    Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Medical School, University of Zagreb, Zagreb, Croatia
    J Neural Transm 110:15-29. 2003
    ..Observed changes may suggest altered response to antidepressants in streptozotocin-icv treated rats, used as an animal model of sporadic Alzheimer's disease...
  53. ncbi Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
  54. ncbi Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study
    KAREN MULLER SMITH
    Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 119:77-85. 2003
    ..These results indicate that the DBH TaqI A allele, or another polymorphism in linkage disequilibrium with this allele, may confer increased susceptibility towards ADHD...
  55. ncbi Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors
    K Buck
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, and Department of Veterans Affairs Research Service, Portland, Oregon 97201, USA
    Am J Med Genet 96:696-705. 2000
    ..These data suggest that the genes influencing locomotor activity, dopamine mimetic sensitivity, and tolerance do not overlap completely...
  56. doi A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions
    Giuseppe De Palma
    Department of Experimental and Applied Medicine, University of Brescia, Italy
    Mov Disord 25:912-9. 2010
    ..Owing to the retrospective design of the study, these results require confirmation...
  57. ncbi Developmental expression of serum response factor in the rat central nervous system
    Janet L Stringer
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res Dev Brain Res 138:81-6. 2002
    ..that of myotonic dystrophy protein kinase, a potential upstream regulator, and of the LIM-only genes Lmo1, Lmo2 and Lmo3, whose products belong to a family of proteins known to be strong positive regulators of SRF's transcriptional ..
  58. pmc Smoking-specific parenting and smoking onset in adolescence: the role of genes from the dopaminergic system (DRD2, DRD4, DAT1 genotypes)
    Marieke Hiemstra
    Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    PLoS ONE 8:e61673. 2013
    ..In conclusion, the findings indicated that the effects of smoking-specific parenting on smoking are similar for adolescent carriers and non-carriers of the dopaminergic system genes...
  59. doi Dopaminergic and noradrenergic gene polymorphisms and response to methylphenidate in korean children with attention-deficit/hyperactivity disorder: is there an interaction?
    Soon Beom Hong
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Child Adolesc Psychopharmacol 22:343-52. 2012
    ....
  60. ncbi Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder
    Claudia Szobot
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 132:53-8. 2005
    ..05). Our findings suggest that a higher recruitment in middle temporal gyrus, an area associated to working memory and selective attention, should exist to compensate a putative effect of the interaction between these dopaminergic genes...
  61. ncbi [Genetic bases of attention deficit hyperactivity disorder]
    C Sánchez-Mora
    Hospital Universitari Vall d Hebron, Barcelona, Espana
    Rev Neurol 55:609-18. 2012
    ....
  62. doi Atrazine biodegradation by Arthrobacter strain DAT1: effect of glucose supplementation and change of the soil microbial community
    Shuguang Xie
    College of Environmental Sciences and Engineering, The Key Laboratory of Water and Sediment Sciences Ministry of Education, Peking University, Beijing, 100871, China
    Environ Sci Pollut Res Int 20:4078-84. 2013
    ..Further study will be necessary in order to elucidate the impact of exogenous carbon on autochthonous and inoculated degraders. This study could add some new insights on atrazine bioremediation...
  63. doi Dopamine transporter genotype predicts attentional asymmetry in healthy adults
    Daniel P Newman
    Monash University, School of Psychology and Psychiatry, Victoria, Australia
    Neuropsychologia 50:2823-9. 2012
    ..These data add to a growing body of evidence showing that spatial attentional asymmetry is a stable quantitative trait, with individual differences in this trait significantly predicted by common DNA variation in the DAT1 gene...
  64. doi Association between the DAT1 gene and spatial working memory in attention deficit hyperactivity disorder
    Chi Yung Shang
    Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    Int J Neuropsychopharmacol 17:9-21. 2014
    ....
  65. ncbi Molecular genetic aspects of attention-deficit/hyperactivity disorder
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Neurosci Biobehav Rev 28:625-41. 2004
    ..The molecular results mentioned above are presented and discussed in detail, thus providing both clinicians and geneticists with an overview of the current research status of this important child and adolescent psychiatric disorder...
  66. doi Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology
    Lea Thaler
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:120-8. 2012
    ..We discuss the implications of our observations...
  67. doi Dopamine transporter gene moderates response to behavioral parent training in children with ADHD: a pilot study
    Barbara J van den Hoofdakker
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Dev Psychol 48:567-74. 2012
    ....
  68. pmc Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors
    Kenneth Blum
    Department of Psychiatry, School of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL 32601, USA
    Int J Environ Res Public Health 8:4425-59. 2011
    ..Utilization of a nonspecific "reward" phenotype may be a paradigm shift in future association and linkage studies involving dopaminergic polymorphisms and other neurotransmitter gene candidates...
  69. doi Association of intron 1 variants of the dopamine transporter gene with schizophrenia
    Chunming Zheng
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing 100005, China
    Neurosci Lett 513:137-40. 2012
    ..The present results suggest that the DAT1 gene may be mainly involved in the development of the positive symptoms in the Chinese population...
  70. ncbi Aberrant responses in social interaction of dopamine transporter knockout mice
    Ramona M Rodriguiz
    Department of Psychiatry, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 148:185-98. 2004
    ..These data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses...
  71. pmc Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging
    Esther Aarts
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:1943-51. 2010
    ..These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control...
  72. ncbi Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder
    Tatiana Roman
    Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
    Am J Pharmacogenomics 4:83-92. 2004
    ....
  73. ncbi Functional effects of the DAT1 polymorphism on EEG measures in ADHD
    Sandra K Loo
    Department of Psychiatry and Biobehavioral Sciences, UCLA NPI, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 42:986-93. 2003
    ..This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD)...
  74. ncbi Potent trypsin-resistant hGH-RH analogues
    Jan Izdebski
    Peptide Laboratory, Department of Chemistry, Warsaw University, Pasteura 1, 02 093 Warsaw, Poland
    J Pept Sci 10:524-9. 2004
    ..These peptides are candidates for clinical application in the therapy of GH deficiency...
  75. pmc Molecular genetics of attention-deficit/hyperactivity disorder: an overview
    Tobias Banaschewski
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Eur Child Adolesc Psychiatry 19:237-57. 2010
    ....
  76. ncbi Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity
    G L Hinks
    Medical Research Council Cambridge Centre for Brain Repair, Forvie Site, Cambridge CB2 2PY, United Kingdom
    J Neurosci 17:5549-59. 1997
    ..Lmo1, Lmo2, and Lmo3 are LIM-only genes originally identified as putative oncogenes that have been implicated in the control of cell ..
  77. doi Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context
    Manuel Garcia-Garcia
    Institute for Brain, Cognition and Behavior IR3C, University of Barcelona, Barcelona, Spain
    Neuropsychologia 48:1483-8. 2010
    ..The present results might help to understand the functional implications of dopamine in some neuropsychiatric disorders...
  78. ncbi Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  79. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
    ..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD...
  80. ncbi Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
    S Durston
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 10:678-85. 2005
    ....
  81. doi Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations
    L V K S Bhaskar
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Neurol Sci 30:487-93. 2009
    ..Heterozygosity indices were low and varied from 0.114 to 0.406. The results demonstrate the variability of the DAT1 40-bp VNTR polymorphism in Indian populations and revealed a high similarity with East Asian populations...
  82. ncbi Association analysis of the dopamine transporter (DAT1)-67A/T polymorphism in bipolar disorder
    M R Keikhaee
    Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Evin, Tehran, Iran
    Am J Med Genet B Neuropsychiatr Genet 135:47-9. 2005
    ..6 and P < or = 0.7, respectively). Replication studies of independent samples and family-based association studies are necessary to further evaluate the significance of our findings...
  83. ncbi Genetic influences on quantity of alcohol consumed by adolescents and young adults
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C 268 35, Denver, CO 80262, USA
    Drug Alcohol Depend 78:187-93. 2005
    ..To examine genetic and environmental influences on drinking in a nationally representative study of genetically informative adolescents followed into young adulthood...
  84. pmc Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
    ....
  85. doi Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity
    Claudia M Szobot
    ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre HCPA, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brasil
    Synapse 65:154-9. 2011
    ..The goal of this study was to evaluate whether ADHD risk alleles at DRD4 and DAT1 genes could predict the change in striatal DAT occupancy after treatment with MPH in adolescents with ADHD/SUDs...
  86. ncbi The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children
    D C Rowe
    University of Arizona, Tucson 85721, USA
    Behav Genet 28:215-25. 1998
    ..Although the residuals were associated less strongly with DAT1 than were the original scores, three disorders continued to show association both between and within families: generalized anxiety, Tourette's, and social phobia...
  87. ncbi Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
    Biol Psychiatry 49:333-9. 2001
    ..This association was later replicated in additional studies...
  88. ncbi Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization
    J Shi
    Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, People s Republic of China
    Brain Res 910:29-37. 2001
    ..Our results have provided a foundation for better understanding of the molecular basis of glial cell functions in dopaminergic transmission and an approach to find possible medication for the related disorders...
  89. ncbi Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002
    ..These data provide direct evidence that the VNTR, or another polymorphism in linkage disequilibrium with the VNTR, is involved in regulating expression of this gene...
  90. doi fMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD
    Wouter Braet
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Neuropsychologia 49:1641-50. 2011
    ..Finally, the ADHD group displayed decreased activation in parietal and (pre)frontal regions during response inhibition, and in frontal and medial brain regions on error trials...
  91. pmc Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing
    Stefanie C Biehl
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e28396. 2011
    ..They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes...
  92. doi Increased DNA methylation of neuropsychiatric genes occurs in borderline personality disorder
    Gerhard Dammann
    Psychiatric Hospital, Muensterlingen, Switzerland
    Epigenetics 6:1454-62. 2011
    ..7%) occurred in blood samples of BPD patients (p < 0.0001). Our data suggest that aberrant epigenetic regulation of neuropsychiatric genes may contribute to the pathogenesis of BPD...
  93. doi When control fails: influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task
    Stefanie Schulz
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Neuropharmacology 62:1028-33. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  94. doi Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability
    Aneek Das Bhowmik
    Manovikas Biomedical Research and Diagnostic Centre, Kolkata 700107, India
    Prog Neuropsychopharmacol Biol Psychiatry 35:1714-22. 2011
    ..Therefore, an alteration in dopaminergic neurotransmission could be predicted that may lead to impairments in cognition and behavioral problems...
  95. doi Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies
    Oussama Kebir
    INSERM, U894, University Paris Descartes, Paris, France
    Eur Arch Psychiatry Clin Neurosci 261:583-94. 2011
    ..The other genes were investigated in fewer studies, and the reported findings need to be replicated. The principal methodological issues that could represent confounding factors and may explain conflicting results are discussed...
  96. doi Dopaminergic system genes in childhood aggression: possible role for DRD2
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    World J Biol Psychiatry 13:65-74. 2012
    ..OBJECTIVE. We examined selected members of the dopaminergic system genes for association with child aggression...
  97. ncbi Dopamine transporter genotype influences the physiological response to medication in ADHD
    Donald L Gilbert
    Division of Neurology Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Brain 129:2038-46. 2006
    ..In conclusion, MPH and ATX have similar effects on SICI in children with ADHD. A genetic variation in DAT1, previously linked to ADHD risk and MPH behavioural responses, influences the neurophysiological effects of both MPH and ATX...
  98. ncbi The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample
    C K Chen
    Department of Psychiatry, Chang Gung Memorial Hospital, Taiwan
    Mol Psychiatry 8:393-6. 2003
    ..3% in the un-transmitted parental alleles and 94.5% in the ADHD probands. These data support the role of DAT1 in ADHD susceptibility among Asian populations...
  99. pmc Dopaminergic Control of Attentional Flexibility: Inhibition of Return is Associated with the Dopamine Transporter Gene (DAT1)
    Lorenza S Colzato
    Institute for Psychological Research and Leiden Institute for Brain and Cognition, Leiden University Leiden, Netherlands
    Front Hum Neurosci 4:53. 2010
    ..Our findings support the idea that striatal DA levels promote IOR, presumably by biasing the interplay between prefrontal and striatal networks towards greater cognitive flexibility...
  100. pmc Infantile parkinsonism-dystonia: a dopamine "transportopathy"
    Craig Blackstone
    Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 119:1455-8. 2009
    ..This is the first report of a genetic alteration in DAT function underlying a parkinsonian disorder...
  101. ncbi Attention-deficit/hyperactivity disorder pharmacogenomics
    James J McGough
    Neuropsychiatric Institute and David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 57:1367-73. 2005
    ..Future studies should emphasize large, prospective trials, assess multiple medications in individual subjects, and consider a full range of pharmacodynamic and pharmacokinetic outcomes...

Research Grants79

  1. Imaging the Neural Correlates of Genetic Risk for ADHD
    Clinton Kilts; Fiscal Year: 2005
    ..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
  2. Function of LIM-domain Transcriptional Regulators in Inner Ear Development
    Lin Gan; Fiscal Year: 2009
    ..sensory organ and that the negative regulation of Isl1 function by the LIM-domain-only transcriptional regulators LMO3 and LMO4 restricts the competence to the presumptive OC (OC) region...
  3. Function of LIM-domain Transcriptional Regulators in Inner Ear Development
    Lin Gan; Fiscal Year: 2010
    ..sensory organ and that the negative regulation of Isl1 function by the LIM-domain-only transcriptional regulators LMO3 and LMO4 restricts the competence to the presumptive OC (OC) region...
  4. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael C Stevens; Fiscal Year: 2010
    ....
  5. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael Stevens; Fiscal Year: 2009
    ....
  6. INVESTIGATION OF ANG II/AT1 RECEPTORS WITH PET
    Zsolt Szabo; Fiscal Year: 2005
    ..The proposed studies will not only help elucidate the involvement of AT1 receptors in RVH but will potentially facilitate efforts to differentiate patients with renovascular hypertension who may benefit from revascularization. ..
  7. NKX2-1, A Candidate Lineage Survival Oncogene in Lung Adenocarcinoma
    Matthew L Meyerson; Fiscal Year: 2010
    ..3 amplicon that is required for lung adenocarcinoma cell survival. Specific Aim 3. Assess whether the LMO3 transcription factor gene is required for the survival of lung adenocarcinoma cells with and without NKX2-1 ..
  8. Methylphenidate Use to Improve Outcomes in Geriatric Depression
    Helen Lavretsky; Fiscal Year: 2010
    ..Evaluating selected dopamine-related genes in late-life depression with respect to mood and cognitive symptoms, and treatment response may lead to the development of the targeted individualized treatments in geriatric depression. ..
  9. ANG II/AT1 RECEPTORS WITH PET
    Zsolt Szabo; Fiscal Year: 1999
    ....
  10. NEUROBIOLOGY OF COCAINE INDUCED SENSITIZATION
    Marc Laruelle; Fiscal Year: 1999
    ....
  11. Gene x Environment Interactions in Attention Deficit Hyperactivity Disorder
    Holly Barnard; Fiscal Year: 2007
    ....
  12. Genetic Polymorphism of a Schizophrenia Endophenotype
    Ikwunga Wonodi; Fiscal Year: 2007
    ..Deciphering the genetic mechanisms of prefrontal dopamine dysfunction in schizophrenia would advance our understanding of the pathophysiology of schizophrenia and may help identify novel treatments. ..
  13. Integrating brain imaging and genetic analysis of ADHD
    CHANDAN VAIDYA; Fiscal Year: 2007
    ..Examination of such genotype-phenotype relationships will elucidate potential etiological factors and neuropathophysiology of ADHD that will be useful in diagnosis, early intervention, and treatment planning. ..
  14. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2007
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. ..
  15. GENETICS OF ADHD
    Josephine Elia; Fiscal Year: 2007
    ..Dr. Douglas Levinson will provide mentoring in statistical methods and data analyses and Dr. Judith Rapoport will provide mentoring in defining novel phenotypic definitions for ADHD. ..
  16. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006
    ..Genomic haplotypes", meaning haplo-specific genotypes at more than one locus, will be defined and tested for possible interactive roles among the genes. ..
  17. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2005
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  18. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  19. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  20. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  21. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2009
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  22. Genetics of EEG Patterns in ADHD
    Sandra Loo; Fiscal Year: 2007
    ..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
  23. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  24. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  25. Molecular Genetics of Inattention in Australia
    RICHARD TODD; Fiscal Year: 2007
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  26. Integrating contextual, proximal, and individual risks for child conduct problems
    S Alexandra Burt; Fiscal Year: 2010
    ..Such findings should ultimately inform individually-tailored interventions aimed at the amelioration of child CP. ..
  27. Gene-environment Interactions in Childhood Conduct Problems
    S Alexandra Burt; Fiscal Year: 2010
    ..Such findings should ultimately provide information for more effective individually-tailored interventions aimed at the amelioration of child CP. ..
  28. Gene-environment Interactions in Childhood Conduct Problems
    S Burt; Fiscal Year: 2009
    ..Such findings should ultimately provide information for more effective individually-tailored interventions aimed at the amelioration of child CP. ..
  29. Endophenotypes for Molecular Genetic Studies of ADHD
    Ian Gizer; Fiscal Year: 2006
    ..abstract_text> ..