Gene Symbol: LMO3
Description: LIM domain only 3
Alias: RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only protein 3, LIM domain only 3 (rhombotin-like 2), neuronal-specific transcription factor DAT1, rhombotin-3
Species: human
Products:     LMO3

Top Publications

  1. Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, et al. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res. 2005;65:4587-97 pubmed
    LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination and differentiation during embryonic development...
  2. Kwon Y, Lee S, Koh J, Kim S, Lee H, Kang M, et al. Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. J Thorac Oncol. 2012;7:20-33 pubmed publisher
    ..DNA methylation pattern and the gene expression profile, we identified the six genes (CCDC37, CYTL1, CDO1, SLIT2, LMO3, and SERPINB5) that are regulated by DNA methylation, and we suggest their value as target molecules for further ..
  3. Barrand S, Crowley T, Wood Bradley R, De Jong K, Armitage J. Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats. PLoS ONE. 2017;12:e0189492 pubmed publisher
  4. Gatt J, Burton K, Williams L, Schofield P. Specific and common genes implicated across major mental disorders: a review of meta-analysis studies. J Psychiatr Res. 2015;60:1-13 pubmed publisher
    ..This review highlights the progress that is being made in identifying shared and unique genetic mechanisms that contribute to the risk of developing several major psychiatric disorders, and identifies further steps for progress. ..
  5. Sarty K, Cowie A, Martyniuk C. The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2017;194:37-47 pubmed publisher
    ..This is an important consideration when incorporating transcriptomics into embryo testing as expression levels can change with removal of the chorion prior to exposure. ..
  6. Kamradt J, Nigg J, Friderici K, Nikolas M. Neuropsychological performance measures as intermediate phenotypes for attention-deficit/hyperactivity disorder: A multiple mediation analysis. Dev Psychopathol. 2017;29:259-272 pubmed publisher
  7. Geissler J, Romanos M, Gerlach M, Berg D, Schulte C. No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs. Atten Defic Hyperact Disord. 2017;9:121-127 pubmed publisher
    ..No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD. ..
  8. Sherif M, Radhakrishnan R, D Souza D, Ranganathan M. Human Laboratory Studies on Cannabinoids and Psychosis. Biol Psychiatry. 2016;79:526-38 pubmed publisher
  9. Ho T, Serie D, Parasramka M, Cheville J, Bot B, Tan W, et al. Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes. Ann Oncol. 2017;28:604-610 pubmed publisher
    ..involved in the formation of the extracellular matrix (ECM): DCN, SLIT2, LUM, LAMA2, ADAMTS12, CEACAM6 and LMO3. In primary ccRCC, CEACAM6 and LUM were significantly associated with metastasis-free and overall survival (Pâ€..

More Information

Publications136 found, 100 shown here

  1. Yu C, Du J, Chiou H, Feng C, Chung M, Yang W, et al. Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..05). Similar results were obtained when females were excluded. Our findings highlighted the adverse correlation between SSB consumption and ADHD and indicated a dose-response effect even after covariates were adjusted. ..
  2. Richards J, Arias Vasquez A, van Rooij D, van der Meer D, Franke B, Hoekstra P, et al. Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition. World J Biol Psychiatry. 2017;18:308-321 pubmed publisher
    ..Positive and negative social environments were related to inhibitory control. This extends previous research emphasizing adverse environments. ..
  3. Bifsha P, Balsalobre A, Drouin J. Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons. Mol Neurobiol. 2017;54:4921-4935 pubmed publisher
    ..We focused on Lmo3 for its preferential expression in SNc neurons and demonstrated that it functions as a transcriptional co-activator ..
  4. Srivastav S, Walitza S, Grunblatt E. Emerging role of miRNA in attention deficit hyperactivity disorder: a systematic review. Atten Defic Hyperact Disord. 2018;10:49-63 pubmed publisher
    ..Therefore, deciphering the role of miRNAs in ADHD seems a promising step in understanding its aetiology. ..
  5. Wang Y, Wegener G, Hou J, Wang F, Xiao X. Expanding anaerobic alkane metabolism in the domain of Archaea. Nat Microbiol. 2019;: pubmed publisher
    ..Archaeoglobi WYZ-LMO1 and WYZ-LMO3 and Korarchaeota WYZ-LMO9 encode both the (reverse) methanogenesis and the dissimilatory sulfate reduction pathway, ..
  6. Ambele M, Dessels C, Durandt C, Pepper M. Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation. Stem Cell Res. 2016;16:725-34 pubmed publisher
    ..Down-regulated genes were enriched for immune response processes. KLF15, LMO3, FOXO1 and ZBTB16 transcription factors were up-regulated throughout the differentiation process...
  7. Hopkins E, Wallace M, Conley Y, Marazita M. Symptoms of attention-deficit hyperactivity disorder, nonsyndromic orofacial cleft children, and dopamine polymorphisms: a pilot study. Biol Res Nurs. 2015;17:257-62 pubmed publisher
    ..04). Results indicate that further investigation among a larger sample of children with OFC is warranted, particularly for relationships with inattentive ADHD. ..
  8. Tung I, Morgan J, Norona A, Lee S. Prenatal programming of postnatal plasticity for externalizing behavior: Testing an integrated developmental model of genetic and temperamental sensitivity to the environment. Dev Psychobiol. 2017;59:984-996 pubmed publisher
    ..We discuss theoretical and empirical implications for models of environmental sensitivity. ..
  9. van der Voet M, Harich B, Franke B, Schenck A. ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila. Mol Psychiatry. 2016;21:565-73 pubmed publisher
    ..It represents an equally useful outcome measure for testing chemical compounds to define novel treatment options. ..
  10. Satterfield B, Wisor J, Schmidt M, Van Dongen H. Time-on-Task Effect during Sleep Deprivation in Healthy Young Adults Is Modulated by Dopamine Transporter Genotype. Sleep. 2017;: pubmed publisher
    ..We probed these mechanisms by investigating genotype-phenotype relationships on psychomotor vigilance test (PVT) performance for three a-priori selected genes previously linked to the TOT effect and/or TSD: DAT1, COMT, and TNF?...
  11. Vasudevan S, Thomas S, Sivakumar K, Komalam R, Sreerekha K, Rajasekharan K, et al. Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance. Carcinogenesis. 2015;36:883-93 pubmed publisher
    ..However, resistance against small molecules is transient, specific and is contributed by target specific changes and variations in apoptotic factors. ..
  12. Jackson D, Beaver K. Sibling differences in low birth weight, dopaminergic polymorphisms, and ADHD symptomatology: evidence of GxE. Psychiatry Res. 2015;226:467-73 pubmed publisher
    ..Limitations and directions for future research are discussed. ..
  13. Das Bhowmik A, Sarkar K, Ghosh P, Das M, Bhaduri N, Sarkar K, et al. Significance of Dopaminergic Gene Variants in the Male Biasness of ADHD. J Atten Disord. 2017;21:200-208 pubmed publisher
    ..008). Interaction between DBH gene variants and low enzymatic activity was also noticed, especially in male probands. Data obtained may partly answer the male biasness of ADHD. ..
  14. Lee D, Brooks Gunn J, McLanahan S, Notterman D, GARFINKEL I. The Great Recession, genetic sensitivity, and maternal harsh parenting. Proc Natl Acad Sci U S A. 2013;110:13780-4 pubmed publisher
    ..We found no evidence of a moderating effect for two other, less well-studied SNPs from the DRD4 and DAT1 genes. ..
  15. Chhangur R, Weeland J, Overbeek G, Matthys W, Orobio de Castro B, Van der Giessen D, et al. Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children. Child Dev. 2017;88:796-811 pubmed publisher
    ..These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity). ..
  16. Galitzky J, Bouloumie A. Human visceral-fat-specific glucocorticoid tuning of adipogenesis. Cell Metab. 2013;18:3-5 pubmed publisher
    ..In this issue of Cell Metabolism, Lindroos et al. identify LIM domain only 3 as a molecular partner for glucocorticoids required for adipocyte differentiation specifically in human visceral fat. ..
  17. Tong J, Cummins T, Johnson B, McKinley L, Pickering H, Fanning P, et al. An association between a dopamine transporter gene (SLC6A3) haplotype and ADHD symptom measures in nonclinical adults. Am J Med Genet B Neuropsychiatr Genet. 2015;168B:89-96 pubmed publisher
    ..Our results provide further support for the influence of variation in the 10/6 DAT1 haplotype and individual differences in ADHD symptoms in adults. ..
  18. Tokko T, Eensoo D, Vaht M, Lesch K, Reif A, Harro J. Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity. Acta Neuropsychiatr. 2019;31:84-92 pubmed publisher
    ..Established biological markers of alcohol use and impulsivity can be reliably associated with everyday traffic behaviour and help in contributing to the understanding of the need for more personalized prevention activities. ..
  19. Cui C, Tian X, Lin Y, Su M, Chen Q, Wang S, et al. In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice. Cell Immunol. 2019;335:22-29 pubmed publisher
    ..We show here that in vivo administration of recombinant BTNL2-IgG2a Fc (rBTNL2-Ig) fusion protein ameliorates GVHD in mice...
  20. Li J, Lee S. Interaction of dopamine transporter gene and observed parenting behaviors on attention-deficit/hyperactivity disorder: a structural equation modeling approach. J Clin Child Adolesc Psychol. 2013;42:174-86 pubmed publisher
    ..Clinical implications for interactions between parenting behavior and child genotype are discussed. ..
  21. Hayden E, Hanna B, Sheikh H, Laptook R, Kim J, Singh S, et al. Child dopamine active transporter 1 genotype and parenting: evidence for evocative gene-environment correlations. Dev Psychopathol. 2013;25:163-73 pubmed publisher
    ..The findings implicate a specific polymorphism in eliciting negative parenting, suggesting that evocative associations play a role in elevating children's risk for emotional trajectories toward psychopathology risk. ..
  22. Onnink A, Franke B, van Hulzen K, Zwiers M, Mostert J, Schene A, et al. Enlarged striatal volume in adults with ADHD carrying the 9-6 haplotype of the dopamine transporter gene DAT1. J Neural Transm (Vienna). 2016;123:905-15 pubmed publisher
    ..This study emphasizes the need of a lifespan approach in genetic studies of ADHD. ..
  23. Mata R, Hau R, Papassotiropoulos A, Hertwig R. DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART). PLoS ONE. 2012;7:e39135 pubmed publisher
    ..Overall, our results support the notion that a behavioral genetic approach can be helpful in uncovering the basis of individual differences in risk taking. ..
  24. Kibitov А, Krupitsky Е, Blokhina Е, Verbitskaya Е, Brodyansky V, Alekseeva N, et al. [A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine]. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116:36-48 pubmed publisher
  25. Watts S, McNulty T. Genes, Parenting, Self-Control, and Criminal Behavior. Int J Offender Ther Comp Criminol. 2016;60:469-91 pubmed publisher
    ..Thus, MAOA and DAT1 may be implicated in offending because they increase the negative effects of parenting on self-control. Implications for theory are discussed. ..
  26. Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, et al. TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Oncogene. 2017;36:3740-3748 pubmed publisher
    ..a role as a lineage-survival oncogene through transcriptional activation of crucial target genes including ROR1 and LMO3. In the present study, we employed a global proteomic search for proteins that interact with TTF-1 in order to ..
  27. Fagundo A, Fernández Aranda F, de la Torre R, Verdejo García A, Granero R, Penelo E, et al. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. J Psychopharmacol. 2014;28:1170-7 pubmed publisher
    ..Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG. ..
  28. Park J, Sung J, Kim D, Kong I, Hughes T, Kim N. Genetic association of human Corticotropin-Releasing Hormone Receptor 1 (CRHR1) with Internet gaming addiction in Korean male adolescents. BMC Psychiatry. 2018;18:396 pubmed publisher
    ..These findings provide a justification and foundation for further investigation of genetic factors related to IGA. ..
  29. Preuss U, Koller G, Samochowiec A, Zill P, Samochowiec J, Kucharska Mazur J, et al. Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression. Alcohol Alcohol. 2015;50:690-9 pubmed publisher
    ..With findings from genome-wide association studies linking aggression-related traits to second messenger systems, further studies are needed to determine the genetic underpinnings of non-alcohol and alcohol-related aggression. ..
  30. Chmielowiec J, Chmielowiec K, Suchanecka A, Trybek G, Mroczek B, Małecka I, et al. Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..These associations open new possibilities for addiction research. ..
  31. Jeong S, Choi K, Lee K, Kim E, Kim Y, Joo E. Association between the dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder-related traits in healthy adults. Psychiatr Genet. 2015;25:119-26 pubmed publisher
  32. Ding K, Yang J, Reynolds G, Chen B, Shao J, Liu R, et al. DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD. World J Biol Psychiatry. 2017;18:291-299 pubmed publisher
    ..Our findings provide initial evidence for the involvement of the epigenetic alterations of DAT1 in modulating the response to MPH treatment in ADHD, primarily on oppositional and hyperactive-impulsive symptoms. ..
  33. Cao Y, Lin X, Chen L, Ji L, Zhang W. The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene-Gene-Environment Study. J Youth Adolesc. 2018;47:2468-2480 pubmed publisher
    ..More importantly, this study underscores complex polygenic underpinnings of depression and lends support for the gene-gene-environment interactions implicated in the etiology of depressive symptoms. ..
  34. Hiemstra M, Engels R, Barker E, van Schayck O, Otten R. Smoking-specific parenting and smoking onset in adolescence: the role of genes from the dopaminergic system (DRD2, DRD4, DAT1 genotypes). PLoS ONE. 2013;8:e61673 pubmed publisher
    ..In conclusion, the findings indicated that the effects of smoking-specific parenting on smoking are similar for adolescent carriers and non-carriers of the dopaminergic system genes. ..
  35. Arnold C, Gispert S, Bonig H, von Wegner F, Somasundaram S, Kell C. Dopaminergic Modulation of Cognitive Preparation for Overt Reading: Evidence from the Study of Genetic Polymorphisms. Cereb Cortex. 2016;26:1539-1557 pubmed publisher
    ..Our results suggest that dopamine modulates corticobasal interactions on both the cortical and subcortical level but differently depending on the specific cognitive subprocesses involved. ..
  36. Maksimov M, Vaht M, Murd C, Harro J, Bachmann T. Brain dopaminergic system related genetic variability interacts with target/mask timing in metacontrast masking. Neuropsychologia. 2015;71:112-8 pubmed publisher
    ..Implications of this result for the development of psychophysical testing based methods of screening for vulnerability/resilience in relation to the pathology of the dopaminergic systems related attentional dysfunction are considered. ..
  37. Weeland J, Overbeek G, de Castro B, Matthys W. Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. Clin Child Fam Psychol Rev. 2015;18:413-42 pubmed publisher
    ..Possible research strategies to test these mechanisms, and implications for interventions, are discussed. ..
  38. Fine A, Mahler A, Simmons C, Chen C, Moyzis R, Cauffman E. Relations between three dopaminergic system genes, school attachment, and adolescent delinquency. Dev Psychol. 2016;52:1893-1903 pubmed
    ..PsycINFO Database Record ..
  39. Huang C, Lu R, Yen C, Yeh Y, Chou H, Kuo S, et al. Dopamine transporter gene may be associated with bipolar disorder and its personality traits. Eur Arch Psychiatry Clin Neurosci. 2015;265:281-90 pubmed publisher
    ..The DAT1 promoter may be associated with vulnerabilities in BPD. The BPD patients had a higher rate of harm avoidance personality traits than the controls, and DAT1 variants may influence personality traits in patients with BPD. ..
  40. Newman D, Cummins T, Tong J, Johnson B, Pickering H, Fanning P, et al. Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection. J Neurosci. 2014;34:15743-50 pubmed publisher
  41. Yokum S, Marti C, Smolen A, Stice E. Relation of the multilocus genetic composite reflecting high dopamine signaling capacity to future increases in BMI. Appetite. 2015;87:38-45 pubmed publisher
  42. Cheng Y, Hou T, Ping J, Chen T, Yin B. LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling. J Exp Clin Cancer Res. 2018;37:228 pubmed publisher
    In this research, we aimed to investigate the biological functions of LIM domain only 3 (LMO3) in hepatocellular carcinoma (HCC) and uncover the underlying molecular mechanism in it...
  43. Uzun M, Sağlar E, Kucukyildirim S, Erdem B, Unlu H, Mergen H. Association of VNTR polymorphisms in DRD4, 5-HTT and DAT1 genes with obesity. Arch Physiol Biochem. 2015;121:75-9 pubmed publisher
    ..As a conclusion, there was no association between 5-HTT, DAT1 and DRD4 genes VNTR polymorphisms and obesity. ..
  44. Joensen B, Meyer M, Aagaard L. Specific Genes Associated with Adverse Events of Methylphenidate Use in the Pediatric Population: A Systematic Literature Review. J Res Pharm Pract. 2017;6:65-72 pubmed publisher
    ..In the future, more pharmacogenomic studies in ADHD are needed, preferably using randomized, controlled study designs and of longer duration (more than 6 months). ..
  45. Savarese A, Zou M, Kharazia V, Maiya R, Lasek A. Increased behavioral responses to ethanol in Lmo3 knockout mice. Genes Brain Behav. 2014;13:777-83 pubmed publisher
    LIM-domain-only 3 (LMO3) is a transcriptional regulator involved in central nervous system development and neuroblastoma. Our previous studies implicated a potential role for LMO3 in regulating ethanol sensitivity and consumption...
  46. Tzeng N, Lu R, Yeh H, Yeh Y, Huang C, Yen C, et al. The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence. Drug Alcohol Depend. 2015;149:100-7 pubmed publisher
    ..However, the DAT1 gene may not contribute to AD susceptibility and specific personality traits observed in AD among Han Chinese men. ..
  47. Akay A, Kaya G, Kose S, Yazicioglu C, Erkuran H, Güney S, et al. Genetic imaging study with [Tc-99m] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:294-300 pubmed publisher
    ..However,our findings did not support an association between homozygosity for a 10-repeat allele in the DAT1 gene and DAT density, assessedusing[Tc-99m] TRODAT-1SPECT. ..
  48. Habak C, Noreau A, Nagano Saito A, Mejía Constaín B, Degroot C, Strafella A, et al. Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease. Brain. 2014;137:3025-35 pubmed publisher
    ..This effect is stronger for conditions that engage the striatum. Longitudinal studies are warranted to assess this polymorphism's effect on the clinical evolution of patients with Parkinson's disease, especially with cognitive decline. ..
  49. Chung T, Ferrell R, Clark D. Indirect association of DAT1 genotype with executive function through white matter volume in orbitofrontal cortex. Psychiatry Res. 2015;232:76-83 pubmed publisher
    ..Genetic effects on regional WM volume that are linked to behavioral outcomes could ultimately inform the development of tailored interventions that address an individual׳s unique risk factors. ..
  50. Rehan W, Antfolk J, Johansson A, Aminoff M, Sandnabba N, Westberg L, et al. Gene-Environment Correlation Between the Dopamine Transporter Gene (DAT1) Polymorphism and Childhood Experiences of Abuse. J Interpers Violence. 2016;: pubmed
    ..In sum, the results suggested that some genetic components might predispose children to experience childhood abuse and neglect. Possible reasons for this association were discussed. ..
  51. Ornoy A, Finkel Pekarsky V, Peles E, Adelson M, Schreiber S, Ebstein P. ADHD risk alleles associated with opiate addiction: study of addicted parents and their children. Pediatr Res. 2016;80:228-36 pubmed publisher
    ..Serotonergic and dopaminergic risk alleles seem to be mainly related to opiate dependence with no effect on the occurrence of ADHD. People carrying those polymorphisms are susceptible to opioid addiction and not necessarily to ADHD. ..
  52. Sukhodol skaia E, Vasil ev V, Shibalev D, Shcherbakova O, Kulikov A, LazebnyÄ­ O, et al. [The 3'-UTR polymorphism of dopamine transporter gene in hadza and datoga males]. Mol Biol (Mosk). 2014;48:295-9 pubmed
    ..We suggest that variations of the repeats num ber and type in the 3'-UTR of allelic variants may affect the dopamine transporter gene function. ..
  53. D Souza S, Thompson J, Slykerman R, Marlow G, Wall C, Murphy R, et al. Environmental and genetic determinants of childhood depression: The roles of DAT1 and the antenatal environment. J Affect Disord. 2016;197:151-8 pubmed publisher
    ..These findings suggest that adverse intrauterine environments leading to low birth weight also seem to exacerbate the effects of certain DAT1 variants on depression. ..
  54. Brewer A, Nielsen D, Spellicy C, Hamon S, Gingrich J, Thompson Lake D, et al. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenet Genomics. 2015;25:296-304 pubmed publisher
    ..01). The data presented here show for the first time support for the hypothesis that genetic differences in DAT1 contribute to the variation in subjective responses to cocaine among participants with cocaine use disorders. ..
  55. Hong S, Zalesky A, Park S, Yang Y, Park M, Kim B, et al. COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2015;36:367-77 pubmed publisher
    ..The present findings suggest that different layers of dopamine-related genes and interindividual variability in the genetic polymorphisms should be taken into account when investigating the human connectome. ..
  56. Schneider K, Schote A, Meyer J, Frings C. Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention. Cogn Affect Behav Neurosci. 2015;15:104-16 pubmed publisher
    ..The same result was noted for carriers of the DAT1 10-repeat allele. From these findings, we suggest that normal variations of the dopaminergic system impact more strongly on top-down than on bottom-up attention. ..
  57. Hasler R, Salzmann A, Bolzan T, Zimmermann J, Baud P, Giannakopoulos P, et al. DAT1 and DRD4 genes involved in key dimensions of adult ADHD. Neurol Sci. 2015;36:861-9 pubmed publisher
    ..Altogether, our results show the putative involvement of DAT1 and DRD4 genes in the aetiology of ADHD with a main role in modulation of key dimensions of the disorder. ..
  58. Hadi F, Dato S, Carpi F, Prontera P, Crucianelli F, Renda F, et al. A genetic-demographic approach reveals a gender-specific association of SLC6A3/DAT1 40 bp-VNTR with life-expectancy. Biogerontology. 2015;16:365-73 pubmed publisher
    ..Moreover, it is conceivable that DAT1 S*/S* carriers, who are prone to assume "risk" type behaviors, may be dropped out of the "healthy" population by a sort of "demographic selection". ..
  59. Jasiewicz A, Rubiś B, Samochowiec J, Małecka I, Suchanecka A, Jabłoński M, et al. DAT1 methylation changes in alcohol-dependent individuals vs. controls. J Psychiatr Res. 2015;64:130-3 pubmed publisher
    ..0296). Further subsequent studies are necessary to determine whether the methylation change of one (out of 23) CpG site results in DAT expression changes. ..
  60. Apuschkin M, Stilling S, Rahbek Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, et al. A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. Eur J Neurosci. 2015;42:2438-54 pubmed publisher
    ..The current investigation demonstrates that eGFP expression in this mouse line is selective for DAergic neurons, suggesting that the Dat1-eGFP mouse strain constitutes a promising tool for delineating new aspects of DA biology. ..
  61. Xu Y, Chen X, Luo M, Tang Y, Zhang G, Wu D, et al. Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children. J Psychiatr Res. 2015;64:40-50 pubmed publisher
    ..9338. This is, to our knowledge, the first study to clearly demonstrate the associations between epigenetic markers and ADHD, shedding light on the preliminary diagnosis and etiological studies of this widespread disorder. ..
  62. Polanczyk G, Bigarella M, Hutz M, Rohde L. Pharmacogenetic approach for a better drug treatment in children. Curr Pharm Des. 2010;16:2462-73 pubmed
    ..The lessons we have learned from the progress of the pharmacogenetics of ADHD can be relevant for developing pharmacogenetic studies in other child and adolescent psychiatric disorders. ..
  63. Kordi Tamandani D, Sahranavard R, Torkamanzehi A. DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia. Mol Biol Rep. 2012;39:10889-93 pubmed publisher
    ..However, further populations with large sample sizes need to be studied to verify the exact role of BDNF in mental disorders such as schizophrenia. ..
  64. Kaplan N, Vituri A, Korczyn A, Cohen O, Inzelberg R, Yahalom G, et al. Sequence variants in SLC6A3, DRD2, and BDNF genes and time to levodopa-induced dyskinesias in Parkinson's disease. J Mol Neurosci. 2014;53:183-8 pubmed publisher
    ..96 (95 % CI, 2.3-10.9; p?=?4.1?×?10(-5)). This finding should be validated in larger, ethnically diverse PD populations, and the biological mechanism should be explored. ..
  65. Stolf A, Szobot C, Halpern R, Akutagava Martins G, Müller D, Guimarães L, et al. Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3). Neuropsychobiology. 2014;70:44-51 pubmed publisher
    ..The results suggest an influence of the DAT1 gene, namely the 3' VNTR 10.10 genotype. However, more analyses will confirm and clarify its contribution as a possible risk factor for crack cocaine dependence. ..
  66. Kim W, Lee S, Roh Y, Kim S, Choi Y, Mun M, et al. Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA Cell Biol. 2017;36:227-236 pubmed publisher
    ..02; p?<?0.05). These results revealed the genetic association between SLC6A3 and hypertension, and the specific VNTR alleles of SLC6A3 may be a risk factor for hypertension. ..
  67. Silveira P, Pokhvisneva I, Gaudreau H, Atkinson L, Fleming A, Sokolowski M, et al. Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children. Appetite. 2018;120:596-601 pubmed publisher
    ..This may have important implications for obesity prevention in this population. ..
  68. Qiu Y, Jiang N, Zhou Y, Yu K, Gong H, Liao G. LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3? signaling. Int J Mol Med. 2018;41:2755-2763 pubmed publisher
    The present study assessed the biological functions of LIM domain only 3 (LMO3) in gastric cancer (GC) investigated and the underlying molecular mechanisms...
  69. Lu M, Kjellin H, Fotouhi O, Lee L, Nilsson I, Haglund F, et al. Molecular profiles of oxyphilic and chief cell parathyroid adenoma. Mol Cell Endocrinol. 2018;470:84-95 pubmed publisher
    ..of novel dysregulated proteins of interest such as nuclear receptor subfamily 2 group C member 2 (TR4), LIM domain only protein 3 (LMO3) and calcium-binding protein B (S100B)...
  70. Yun I, Lee J, Kim S. Dopaminergic Polymorphisms, Academic Achievement, and Violent Delinquency. Int J Offender Ther Comp Criminol. 2015;59:1409-28 pubmed publisher
    ..The results demonstrated that academic performance fully mediated the linkage between these genes and violent delinquency. ..
  71. Inci Kenar A, Ünal G, Guler H, Albuz B, Kiroglu Y, Erdal M, et al. Relationship between the DAT1 gene and the effects of methylphenidate administration in adult attention deficit hyperactivity disorder: a magnetic resonance spectroscopy study. Eur Rev Med Pharmacol Sci. 2016;20:1373-8 pubmed
    ..Our results thus suggest that the 10R allele as the DAT1 gene VNTR polymorphism might be associated with MPH-related changes in brain metabolites in adults with ADHD. ..
  72. Samek D, Bailey J, Hill K, Wilson S, Lee S, Keyes M, et al. A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies. Behav Genet. 2016;46:608-626 pubmed publisher
    ..After correcting for multiple testing, only one significant main effect was found in the test sample, but it was not replicated. Implications for subsequent gene-environment interplay analyses are discussed. ..
  73. Weerts E, Wand G, Maher B, Xu X, STEPHENS M, Yang X, et al. Independent and Interactive Effects of OPRM1 and DAT1 Polymorphisms on Alcohol Consumption and Subjective Responses in Social Drinkers. Alcohol Clin Exp Res. 2017;41:1093-1104 pubmed publisher
    ..These findings highlight the biological importance of interactions between these 2 genes and interactions between brain opioid and dopamine systems. ..
  74. Savarese A, Lasek A. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Psychoneuroendocrinology. 2018;92:13-20 pubmed publisher
    The LIM domain only protein LMO3 is a transcriptional regulator that has been shown to regulate several behavioral responses to alcohol...
  75. Šerý O, Paclt I, Drtílková I, Theiner P, Kopečková M, Zvolský P, et al. A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism. Behav Brain Funct. 2015;11:21 pubmed publisher
    ..Furthermore, we detected rare genotypes 8/10, 7/10 and 10/11 present in ADHD boys only and identified miRNAs that should be looked at as potential novel targets in the research on ADHD. ..
  76. Isogai E, Okumura K, Saito M, Yoshizawa Y, Itoh K, Tando S, et al. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Exp Anim. 2015;64:407-14 pubmed publisher
    We previously reported that LMO3 and HEN2 act as oncogenes in neuroblastoma development through up-regulating MASH1 transcription by interfering with HES1. To confirm these results in vivo, we generated transgenic mice of these genes...
  77. De Laet S, Colpin H, Van Leeuwen K, Van den Noortgate W, Claes S, Janssens A, et al. Teacher-student relationships and adolescent behavioral engagement and rule-breaking behavior: The moderating role of dopaminergic genes. J Sch Psychol. 2016;56:13-25 pubmed publisher
    ..Implications for understanding the role of teacher-student relationships in adolescence and suggestions for future research are outlined. ..
  78. Notzon S, Vennewald N, Gajewska A, Klahn A, Diemer J, Winter B, et al. Is prepulse modification altered by continuous theta burst stimulation? DAT1 genotype and motor threshold interact on prepulse modification following brain stimulation. Eur Arch Psychiatry Clin Neurosci. 2017;267:767-779 pubmed publisher
    ..The effects in homozygous carriers of the DAT1 10-repeat allele confirm the relevance of dopamine for PPM. Conducting an exploratory study we decided against the use of a correction for multiple testing. ..
  79. Zenchak J, Palmateer B, Dorka N, Brown T, Wagner L, Medendorp W, et al. Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model. J Neurosci Res. 2018;: pubmed publisher
    ..We generated a neuronal precursor cell line expressing luminopsin 3 (LMO3), a luciferase-channelrhodopsin fusion protein, which responds to the luciferase substrate coelenterazine (CTZ) ..
  80. van Rooij D, Hoekstra P, Bralten J, Hakobjan M, Oosterlaan J, Franke B, et al. Influence of DAT1 and COMT variants on neural activation during response inhibition in adolescents with attention-deficit/hyperactivity disorder and healthy controls. Psychol Med. 2015;45:3159-70 pubmed publisher
    ..The limited associations between gene polymorphisms and task performance further indicate the added value of neural measures in linking genetic factors and behavioural measures. ..
  81. Pagerols M, Richarte V, Sánchez Mora C, Garcia Martinez I, Corrales M, Corominas M, et al. Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. Pharmacogenomics J. 2017;17:98-104 pubmed publisher
    ..4e-03; OR=0.28) and DRD2 (P=0.047; OR=3.76). This study suggests that the dopaminergic system together with prenatal smoking exposure may moderate MPH treatment effects. ..
  82. Fernández Jaén A, Albert J, Fernández Mayoralas D, López Martín S, Fernández Perrone A, Jiménez De la Peña M, et al. Cingulate Cortical Thickness and Dopamine Transporter (DAT1) Genotype in Children and Adolescents With ADHD. J Atten Disord. 2016;: pubmed
    ..These findings suggest that thickness of cingulate cortex is influenced by the presence of the 10-repeat allele in ADHD. ..
  83. Akutagava Martins G, Salatino Oliveira A, Kieling C, Genro J, Polanczyk G, Anselmi L, et al. COMT and DAT1 genes are associated with hyperactivity and inattention traits in the 1993 Pelotas Birth Cohort: evidence of sex-specific combined effect. J Psychiatry Neurosci. 2016;41:405-412 pubmed
    ..It also confirms previous evidence for sexual dimorphism on COMT and DAT1 gene expression. ..
  84. Auerbach J, Zilberman Hayun Y, Atzaba Poria N, Berger A. The Contribution of Maternal ADHD Symptomatology, Maternal DAT1, and Home Atmosphere to Child ADHD Symptomatology at 7 Years of Age. J Abnorm Child Psychol. 2017;45:415-427 pubmed publisher
    ..Boys with higher levels of inattentive symptoms came from homes with higher levels of negative atmosphere and had mothers with the homozygous 10/10 genotype. The maternal heterozygous 9/10 genotype did not predict child symptoms. ..
  85. Fernández Jaén A, López Martín S, Albert J, Fernández Mayoralas D, Fernández Perrone A, de La Peña M, et al. Cortical thickness differences in the prefrontal cortex in children and adolescents with ADHD in relation to dopamine transporter (DAT1) genotype. Psychiatry Res. 2015;233:409-17 pubmed publisher
    ..Present findings suggest that cortical thickness of right lateral prefrontal cortex (BA 46) is influenced by the presence of the DAT1 10 repeat allele in children and adolescents with ADHD. ..
  86. Lundwall R, Dannemiller J. Genetic contributions to attentional response time slopes across repeated trials. BMC Neurosci. 2015;16:66 pubmed publisher
    ..Those with no risk alleles (5R/5R) had the most improvement in RT as the task progressed. ..
  87. Thibodeau E, Cicchetti D, Rogosch F. Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Dev Psychopathol. 2015;27:1621-36 pubmed publisher
  88. Ercan E, Suren S, Bacanlı A, Yazici K, Callı C, Ozyurt O, et al. Decreasing ADHD phenotypic heterogeneity: searching for neurobiological underpinnings of the restrictive inattentive phenotype. Eur Child Adolesc Psychiatry. 2016;25:273-82 pubmed publisher
    ..ADHD-RI may represent a different phenotype than other types of ADHD. In addition, our results suggest that reducing the phenotypic heterogeneity may aid in the search for the neurobiological underpinnings of ADHD. ..
  89. Richards J, Arias Vasquez A, von Rhein D, van der Meer D, Franke B, Hoekstra P, et al. Adolescent behavioral and neural reward sensitivity: a test of the differential susceptibility theory. Transl Psychiatry. 2016;6:e771 pubmed publisher
    ..Our results partially confirm the differential susceptibility theory and indicate the importance of positive social environments in reward sensitivity and general task performance for persons with specific genotypes. ..
  90. van der Meer D, Hartman C, van Rooij D, Franke B, Heslenfeld D, Oosterlaan J, et al. Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition. J Psychiatry Neurosci. 2017;42:113-121 pubmed
  91. Roussotte F, Gutman B, Hibar D, Madsen S, Narr K, Thompson P. Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion. Alzheimers Dement. 2015;11:1153-62 pubmed publisher
    ..The same allele was also associated with poorer cognitive performance and faster ventricular expansion, independently of diagnosis. These results may be due to reduced dopaminergic transmission in carriers of the DAT1 mutation. ..
  92. Barker D, Nugent N, Delgado J, Knopik V, Brown L, Lally M, et al. A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. AIDS Care. 2017;29:1186-1191 pubmed publisher
    ..g., depressive symptoms, avoidant coping, trauma history). Caution is required when using a single gene variant as a marker of complex behaviors and these findings need to be replicated using larger samples and additional variants. ..