LMO2

Summary

Gene Symbol: LMO2
Description: LIM domain only 2
Alias: LMO-2, RBTN2, RBTNL1, RHOM2, TTG2, rhombotin-2, LIM domain only protein 2, T-cell translocation gene 2, T-cell translocation protein 2, cysteine-rich protein TTG-2, rhombotin-like 1
Species: human
Products:     LMO2

Top Publications

  1. Yuan W, Sun W, Yang S, Du J, Zhai C, Wang Z, et al. Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. Leukemia. 2008;22:1067-71 pubmed
  2. Wadman I, Li J, Bash R, Forster A, Osada H, Rabbitts T, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 1994;13:4831-9 pubmed
    ..RBTN1 and RBTN2 encode highly related proteins that possess cysteine-rich LIM motifs...
  3. Mao S, Neale G, Goorha R. T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. Oncogene. 1997;14:1531-9 pubmed
    ..Additional functions for RBTN2 are indicated by its expression in non-hematopoietic tissues...
  4. Wadman I, Osada H, Grutz G, Agulnick A, Westphal H, Forster A, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 1997;16:3145-57 pubmed
    The LIM-only protein Lmo2, activated by chromosomal translocations in T-cell leukaemias, is normally expressed in haematopoiesis. It interacts with TAL1 and GATA-1 proteins, but the function of the interaction is unexplained...
  5. Manetopoulos C, Hansson A, Karlsson J, Jönsson J, Axelson H. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem Biophys Res Commun. 2003;307:891-9 pubmed
    The basic helix-loop-helix protein HEN1 and the LIM-only proteins LMO2 and LMO4 are expressed in neuronal cells. HEN1 was cloned by virtue of its homology to TAL1, a bHLH protein important for early hematopoiesis...
  6. Hammond S, Crable S, Anderson K. Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. Leuk Res. 2005;29:89-97 pubmed
    Ectopic expression of LMO2 occurs in approximately 45% of T-lineage acute lymphoblastic leukemias (T-ALL), sometimes in association with chromosomal translocations...
  7. Royer Pokora B, Loos U, Ludwig W. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene. 1991;6:1887-93 pubmed
    ..Therefore the proteins encoded by these two translocation-deregulated genes belong to this new class of cysteine-rich proteins with the 'LIM' motif, which are important in normal development. ..
  8. Boehm T, Foroni L, Kaneko Y, Perutz M, Rabbitts T. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991;88:4367-71 pubmed
    ..The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains. ..
  9. Boehm T, Spillantini M, Sofroniew M, Surani M, Rabbitts T. Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. Oncogene. 1991;6:695-703 pubmed

More Information

Publications133 found, 100 shown here

  1. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    ..In this case, TAL1 and LMO act as cofactors for GATA3 to activate the transcription of RALDH2. ..
  2. Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce C, et al. A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. Mol Cell Biol. 2000;20:5330-42 pubmed
    ..complex comprising the tal-1 transcription factor heterodimerized with the ubiquitous E2A protein and linked to Lmo2, Ldb1, and retinoblastoma protein (pRb). The pentamer can assemble on a consensus tal-1 binding site...
  3. Lecuyer E, Herblot S, Saint Denis M, Martin R, Begley C, Porcher C, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002;100:2430-40 pubmed
    ..This complex, containing hematopoietic-specific (SCL, Lim-only 2 (LMO2), GATA-1/GATA-2) and ubiquitous (E2A, LIM- domain binding protein 1 [Ldb-1]) factors, is tethered to DNA via a ..
  4. Crable S, Anderson K. A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene. Blood. 2003;101:4757-64 pubmed
    The transcription factor LMO2 is believed to exert its effect through the formation of protein-protein interactions with other DNA-binding factors such as GATA-1 and TAL1...
  5. Van Vlierberghe P, van Grotel M, Beverloo H, Lee C, Helgason T, Buijs Gladdines J, et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood. 2006;108:3520-9 pubmed
    ..Detailed molecular-cytogenetic analysis revealed that this deletion activates the LMO2 oncogene in 4 of 6 del(11)(p12p13)-positive T-ALL patients, in the same manner as in patients with an LMO2 ..
  6. Xu Z, Meng X, Cai Y, Liang H, Nagarajan L, Brandt S. Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins. Genes Dev. 2007;21:942-55 pubmed
    ..to an erythroid DNA-binding complex that contains the transcription factors Tal1 and GATA-1, the LIM domain protein Lmo2, and Ldb1 and binds a bipartite E-box-GATA DNA sequence motif...
  7. Zhu T, Qin G, Royer Pokora B. A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2. Sci China C Life Sci. 2001;44:561-9 pubmed publisher
    b>Lmo2 is a T cell leukemia-related proto-oncogene, which belongs to the LIM protein family. Previous work has established its key role in yolk sac erythropoiesis and adult hematopoiesis, and it is also necessary for regulating angiogenesis...
  8. Oram S, Thoms J, Pridans C, Janes M, Kinston S, Anand S, et al. A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. Oncogene. 2010;29:5796-808 pubmed publisher
    The T-cell oncogene Lim-only 2 (LMO2) critically influences both normal and malignant haematopoiesis...
  9. Dybkær K, Bøgsted M, Falgreen S, Bødker J, Kjeldsen M, Schmitz A, et al. Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis. J Clin Oncol. 2015;33:1379-88 pubmed publisher
    ..genotype, whereas the centrocyte subtype had high TP53 mutation and insertion/deletion frequencies and expressed LMO2, CD58, and stromal-1-signature and major histocompatibility complex class II-signature genes, which are known to ..
  10. Hacein Bey Abina S, Pai S, Gaspar H, Armant M, Berry C, Blanche S, et al. A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014;371:1407-17 pubmed publisher
    ..trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients...
  11. Katakura F, Katzenback B, Belosevic M. Recombinant goldfish thrombopoietin up-regulates expression of genes involved in thrombocyte development and synergizes with kit ligand A to promote progenitor cell proliferation and colony formation. Dev Comp Immunol. 2015;49:157-69 pubmed publisher
    ..levels of thrombopoietic markers cd41 and c-mpl as well as thrombo/erythropoietic transcription factors gata1 and lmo2 in sorted progenitor cells were up-regulated, while the mRNA levels of granulopoietic markers (cebpα and gcsfr) ..
  12. Xu B, Cai L, Butler J, Chen D, Lu X, Allison D, et al. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports. 2018;10:675-683 pubmed publisher
    ..HSC-specific gene-expression programs, which contain several master transcription factors (Meis1, Pbx1, Mn1, and Lmo2) required for HSC maintenance and self-renewal...
  13. Deucher A, Qi Z, Yu J, George T, Etzell J. BCL6 expression correlates with the t(1;19) translocation in B-lymphoblastic leukemia. Am J Clin Pathol. 2015;143:547-57 pubmed publisher
    ..other markers of B-cell development correlated with BCL6 expression in t(1;19) B-lymphoblastic leukemia cases, with LMO2 and HGAL proteins expressed in six (67%) of nine and eight (89%) of nine cases, respectively...
  14. Luo R, Zhao S, Tibshirani R, Myklebust J, Sanyal M, Fernandez R, et al. CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Hum Pathol. 2010;41:271-80 pubmed publisher
    ..lymphoma, staining for CD81 was most similar to other germinal center B cell-associated markers, particularly LMO2. By flow cytometry, CD81 was expressed in diffuse large B-cell lymphoma cells independent of the presence or ..
  15. Wang X, Liu Y, Dai L, Liu Q, Jia L, Wang H, et al. Foxp3 downregulation in NSCLC mediates epithelial-mesenchymal transition via NF-?B signaling. Oncol Rep. 2016;36:2282-8 pubmed publisher
    ..However, forced expression of Foxp3 could reverse this effect. Moreover, Foxp3 could interact with LMO2 and affect the expression level of TAL1, which was in accordance with the findings in T-cell acute lymphoblastic ..
  16. Beisaw A, Tsaytler P, Koch F, Schmitz S, Melissari M, Senft A, et al. BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 2018;19:118-134 pubmed publisher
    ..We show that this role of T is mediated, at least in part, through activation of a distal Lmo2 enhancer.
  17. Hoang T, Lambert J, Martin R. SCL/TAL1 in Hematopoiesis and Cellular Reprogramming. Curr Top Dev Biol. 2016;118:163-204 pubmed publisher
    ..Interestingly, fate conversion of fibroblasts to hematoendothelial cells requires not only Scl and Lmo2 but also Gata2, Runx1, and Erg, indicating a necessary collaboration between these transcription factors for ..
  18. Liau W, Ngoc P, Sanda T. Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis. Adv Exp Med Biol. 2017;962:139-147 pubmed publisher
    ..RUNX1 and other hematopoietic transcription factors TAL1/SCL, GATA2, PU.1, LMO2 and LDB1 bind at this region...
  19. Minato Y, Kuwahara Otani S, Maeda S, Yagi H. Platelet-derived growth factor receptor α gene is regulated by multiple first exons. Biochem Biophys Res Commun. 2019;510:489-494 pubmed publisher
    ..of both human and mouse PDGFRA/Pdgfra genes predicted common (such as Sry, Mzf1, and Cdx) and unique (such as Sox5, Lmo2, and GATA) transcription factors...
  20. Hewitt K, Johnson K, Gao X, Keles S, Bresnick E. The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms. Curr Top Dev Biol. 2016;118:45-76 pubmed publisher
    ..the basic helix-loop-loop transcription factor Scl/TAL1, its heterodimeric partner E2A, and the Lim domain proteins LMO2 and LDB1...
  21. Love P, Warzecha C, Li L. Ldb1 complexes: the new master regulators of erythroid gene transcription. Trends Genet. 2014;30:1-9 pubmed publisher
    ..proteins are contained within higher order complexes (Ldb1 complexes) that include the nuclear adapters Ldb1 and Lmo2. Ldb1 complexes regulate Klf1, and Ldb1 complex-binding sites frequently colocalize with Klf1 at erythroid genes ..
  22. Garcia P, Miller A, Kreitzburg K, Council L, Gamblin T, Christein J, et al. The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. Oncogene. 2016;35:833-45 pubmed publisher
    ..profiling identified CDC25B, a regulator of cell cycle progression, as one of the three RNA species (TIMP3, LMO2 and CDC25B) downregulated by JQ1 (P<0.05)...
  23. Oliveira V, Mançanares C, Oliveira L, Gonçalves N, Miglino M, Perecin F, et al. Characterization of putative haematopoietic cells from bovine yolk sac. J Tissue Eng Regen Med. 2017;11:1132-1140 pubmed publisher
    ..Quantitative PCR analysis demonstrated the presence of the haematopoietic progenitor genes GATA3 and LMO2, but not RUNX1...
  24. Dawson M, Bannister A, Göttgens B, Foster S, Bartke T, Green A, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature. 2009;461:819-22 pubmed publisher
    ..Inhibition of JAK2 activity in human leukaemic cells decreases both the expression of the haematopoietic oncogene lmo2 and the phosphorylation of H3Y41 at its promoter, while simultaneously increasing the binding of HP1alpha at the ..
  25. Kunder C, Roncador G, Advani R, Gualco G, Bacchi C, Sabile J, et al. KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas. Am J Clin Pathol. 2017;148:465-476 pubmed publisher
    ..In addition to other germinal center markers, including BCL6, CD10, HGAL, and LMO2, KLHL6 immunohistochemistry may prove a useful adjunct in the diagnosis and future classification of B-cell ..
  26. Ranocha P, Francoz E, Burlat V, Dunand C. Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion. Plant Signal Behav. 2014;9:e977734 pubmed publisher
    ..PRX56, DIR12) have been analyzed in T-DNA mutants affected in master TFs (ap2, egl3/gl3, gl2, myb5, tt8, ttg1, ttg2 and luh1/mum1)...
  27. Zhao Z, Chen L, Dawlaty M, Pan F, WEEKS O, Zhou Y, et al. Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice. Cell Rep. 2015;13:1692-704 pubmed publisher
    ..of DKO tumors reveals expression changes in many genes dysregulated in human B cell malignancies, including LMO2, BCL6, and MYC...
  28. Zhang Y, Zhang J, Shao C, Bao Z, Liu G, Bao M. Single-repeat R3 MYB transcription factors from Platanus acerifolia negatively regulate trichome formation in Arabidopsis. Planta. 2019;249:861-877 pubmed publisher
    ..In addition, expression of endogenous GL2, GL1, MYB23, TTG2 and a set of R3 MYB-encoding genes was markedly reduced...
  29. Zhang Y, Zhang J, An W, Wan Y, Ma S, Yin J, et al. Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation. Nucleic Acids Res. 2017;45:657-671 pubmed publisher
    ..promoter, forming a long-range loop to enhance ALAS2 expression by an enhancer complex including GATA1, TAL1, LMO2, LDB1 and Pol II at least, in erythroid cells...
  30. Pitt S, Hernandez R, Nehs M, Gawande A, Moore F, Ruan D, et al. Identification of Novel Oncogenic Mutations in Thyroid Cancer. J Am Coll Surg. 2016;222:1036-1043.e2 pubmed publisher
    ..an additional 13 genes known to have altered protein expression in thyroid cancer: BLM, CBL, CIITA, EP300, GSTM5, LMO2, PRAME, SBDS, SF1, TET2, TNFAIP3, XPO1, and ZRSR2...
  31. Gerby B, Tremblay C, Tremblay M, Rojas Sutterlin S, Herblot S, Hébert J, et al. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet. 2014;10:e1004768 pubmed publisher
    ..Finally, LYL1 and LMO1 or LMO2 are co-expressed in most human T-ALL samples, except the cortical T subtype...
  32. Tan S, Bertulfo F, Sanda T. Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2017;7:218 pubmed publisher
    ..We focus on the oncogenic transcription factors TAL1, LMO2, and NOTCH1 and highlight the significance of the transcriptional regulatory programs in normal ..
  33. Choi H, Rho S, Choi D, Kwon Y. LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB Rep. 2018;51:21-26 pubmed
    ..promoter activity by binding to its promoter region and the same promoter region was occupied and regulated by the LMO2/TAL1/GATA2 complex. Interestingly, LDB2 also mediated VEGF-induced DLL4 expression in endothelial cells...
  34. Abraham B, Hnisz D, Weintraub A, Kwiatkowski N, Li C, Li Z, et al. Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017;8:14385 pubmed publisher
    ..leukaemia tumour genomes, reveals that it nucleates formation of an active enhancer that drives expression of the LMO2 oncogene...
  35. Ginn S, McCormack M, Alexander I. Thymocyte self-renewal and oncogenic risk in immunodeficient mouse models: relevance for human gene therapy clinical trials targeting haematopoietic stem cell populations?. Mamm Genome. 2018;29:771-776 pubmed publisher
    ..thymic residency time, established under conditions of limited cellular competition, may have contributed to oncogenesis observed in early SCID-X1 trials when combined with insertional activation of proto-oncogenes such as LMO2.
  36. Zamani Ahmadmahmudi M, Aghasharif S, Ilbeigi K. Prognostic efficacy of the human B-cell lymphoma prognostic genes in predicting disease-free survival (DFS) in the canine counterpart. BMC Vet Res. 2017;13:17 pubmed publisher
    ..In the univariate analysis, CCND1, CCND2, PAX5, CR2, LMO2, HLA-DQA1, P53, CD38, MYC-N, MYBL1, and BIRCS5 were associated with longer disease-free survival (DFS), while CD44, ..
  37. Visvader J, Mao X, Fujiwara Y, Hahm K, Orkin S. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997;94:13707-12 pubmed
    The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions...
  38. Joshi A, Hannah R, Diamanti E, Göttgens B. Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data. Exp Hematol. 2013;41:354-66.e14 pubmed publisher
    ..gene sets allowed us to predict the reactivation of blood stem cell control mechanisms as a likely contributor to LMO2 driven leukemia...
  39. Lossos C, Bayraktar S, Weinzierl E, Younes S, Hosein P, Tibshirani R, et al. LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma. Br J Haematol. 2014;165:640-8 pubmed publisher
    ..We evaluated 69 cases of PCNSL for the expression of HGAL (also known as GCSAM), LMO2 and BCL6 - genes associated with DLBCL prognosis and pathobiology, and analysed their correlation to survival in 49 ..
  40. Miyashita K, Kitajima K, Goyama S, Kitamura T, Hara T. Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochem Biophys Res Commun. 2018;495:2310-2316 pubmed publisher
    ..The transcriptional co-factor LIM domain only 2 (LMO2) and its target gene HHEX are essential for self-renewal of T cell precursors and T-ALL etiology...
  41. Ostendorff H, Peirano R, Peters M, Schlüter A, Bossenz M, Scheffner M, et al. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002;416:99-103 pubmed
    ..Our data provide a mechanistic basis for cofactor exchange on DNA-bound transcription factors, and probably represent a general mechanism of transcriptional regulation. ..
  42. Newrzela S, Cornils K, Heinrich T, Schläger J, Yi J, Lysenko O, et al. Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes. Mol Med. 2011;17:1223-32 pubmed publisher
    ..immortalization of a single T-cell clone in vitro after gammaretroviral transduction of the T-cell protooncogene LMO2. This clone was CD4/CD8 double-negative, but expressed a single rearranged T-cell receptor...
  43. Chambers J, Rabbitts T. LMO2 at 25 years: a paradigm of chromosomal translocation proteins. Open Biol. 2015;5:150062 pubmed publisher
    b>LMO2 was first discovered through proximity to frequently occurring chromosomal translocations in T cell acute lymphoblastic leukaemia (T-ALL)...
  44. Bian S, Zheng X, Sun H, Chen J, Lu Y, Liu Y, et al. Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signaling in the zebrafish embryo. J Biol Chem. 2017;292:14165-14175 pubmed publisher
    ..of the mesodermal markers ntl, gsc, and eve1 and of the hematopoietic markers scl, lmo2, and fli1a Biochemical analyses revealed that Clock1a stimulates Nodal signaling by increasing ..
  45. Sun W, Yang S, Shen W, Li H, Gao Y, Zhu T. Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia. Eur J Haematol. 2010;85:508-19 pubmed publisher
    The lmo2 gene is a specific oncogene in T-cell leukemia, for its ectopic expression causes both increased pro-T-cell proliferation and differentiation arrest, leading to the onset of leukemia...
  46. Bianchi E, Bulgarelli J, Ruberti S, Rontauroli S, Sacchi G, Norfo R, et al. MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated downregulation of MAF. Cell Death Differ. 2015;22:1906-21 pubmed publisher
    ..demonstrated that MYB controls erythroid versus megakaryocyte lineage decision by transactivating KLF1 and LMO2 expression...
  47. Tremblay C, Brown F, Collett M, Saw J, Chiu S, Sonderegger S, et al. Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia. 2016;30:1993-2001 pubmed publisher
    ..To determine the effects of DNM2 mutations in T-ALL, we bred the Dnm2V265G mice with the Lmo2 transgenic mouse model of T-ALL...
  48. Verdanet E, Dereure O, René C, Tempier A, Benammar Hafidi A, Gallo M, et al. Diagnostic value of STMN1, LMO2, HGAL, AID expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas. Histopathology. 2017;71:648-660 pubmed publisher
    ..the differential diagnosis, we compared expression of immunohistochemical markers [LIM-only transcription factor 2 (LMO2), human germinal centre-associated lymphoma (HGAL), stathmin 1 (STMN1), activation-induced cytidine deaminase (AID),..
  49. Roesch A, Mueller A, Stempfl T, Moehle C, Landthaler M, Vogt T. RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. Int J Cancer. 2008;122:1047-57 pubmed
  50. Han J, Chang S, Cho H, Choi S, Ahn H, Lee J, et al. Direct conversion of adult skin fibroblasts to endothelial cells by defined factors. Circulation. 2014;130:1168-78 pubmed publisher
    ..Serial stepwise screening revealed 5 key factors (Foxo1, Er71, Klf2, Tal1, and Lmo2) that were required for efficient reprogramming of skin fibroblasts into Tie2-GFP(+) cells (4%)...
  51. Karnik T, Ozawa M, Lefterova M, Luna Fineman S, Alvarez E, Link M, et al. The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. Hum Pathol. 2015;46:629-33 pubmed publisher
    ..dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas...
  52. Sun K, Huang Y, Palanisamy K, Chang S, Wang I, Wu K, et al. Reciprocal regulation of ?-globin expression by exo-miRNAs: Relevance to ?-globin silencing in ?-thalassemia major. Sci Rep. 2017;7:202 pubmed publisher
    ..TM exosomes and miR-223-3p down regulated ?-globin expression through LMO2 targeting. Importantly, miR-223-3p targeting through sponge repression resulted in ?-globin activation...
  53. Natkunam Y, Zhao S, Mason D, Chen J, Taidi B, Jones M, et al. The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. Blood. 2007;109:1636-42 pubmed
    We previously developed a multivariate model based on the RNA expression of 6 genes (LMO2, BCL6, FN1, CCND2, SCYA3, and BCL2) that predicts survival in diffuse large B-cell lymphoma (DLBCL) patients...
  54. Sang M, Ma L, Sang M, Zhou X, Gao W, Geng C. LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins. Mol Biol Rep. 2014;41:1067-73 pubmed publisher
    ..We also summarized the interaction proteins of each LMO family member, which may contribute to elucidating the functions of these mysterious and important linker proteins. ..
  55. Braghini C, Costa F, Fedosyuk H, Neades R, Novikova L, Parker M, et al. Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH. Exp Biol Med (Maywood). 2016;241:697-705 pubmed publisher
    ..was examined by chromatin immunoprecipitation of transcription factor/co-factor binding, including YY1, PAX1, TAL1, LMO2, and LDB1...
  56. Peckova K, Michal M, Hadravsky L, Suster S, Damjanov I, Miesbauerova M, et al. Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. Histopathology. 2016;69:762-774 pubmed publisher
    ..for LYVE-1, factor VIII, FLI-1, vascular endothelial growth factor receptor (VEGFR)-2, VEGFR-3, claudin-5, ERG, LMO2, CD31, CD163, lysozyme, and CD4, but negative for D2-40, CD8, and factor XIIIa...
  57. Bégay Müller V, Ansieau S, Leutz A. The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene. FEBS Lett. 2002;521:36-8 pubmed
    The LIM only protein Lmo2 plays an important role in hematopoiesis and leukemogenesis. Lmo2 acts as a bridging molecule between components of hematopoietic gene regulatory protein complexes...
  58. Deane J, Mackay J, Kwan A, Sum E, Visvader J, Matthews J. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J. 2003;22:2224-33 pubmed
    b>LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development and disease processes...
  59. Goardon N, Lambert J, Rodriguez P, Nissaire P, Herblot S, Thibault P, et al. ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J. 2006;25:357-66 pubmed
    ..In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldb1, we identify the ETO2 repressor as a novel component recruited to TAL-1 complexes through interaction with ..
  60. Colomo L, Vázquez I, Papaleo N, Espinet B, Ferrer A, Franco C, et al. LMO2-negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas. Am J Surg Pathol. 2017;41:877-886 pubmed publisher
    ..b>LMO2 is a germinal center marker expressed in most lymphomas originated in these cells...
  61. Sanchez Garcia I, Axelson H, Rabbitts T. Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2. Oncogene. 1995;10:1301-6 pubmed
    The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias...
  62. Wilkinson D, Neale G, Mao S, Naeve C, Goorha R. Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. Leukemia. 1997;11:86-96 pubmed
    ..In contrast, when RBTN-2 is inappropriately expressed in T cells, RBTN-2 would interact predominantly with elf-2b; this interaction may lead to T cell proliferation. ..
  63. Cubedo E, Gentles A, Huang C, Natkunam Y, Bhatt S, Lu X, et al. Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma. Blood. 2012;119:5478-91 pubmed publisher
    b>LMO2 regulates gene expression by facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the germinal center (GC) and is expressed in GC-derived non-Hodgkin lymphomas...
  64. Patel J, Pournazari P, Haggstrom S, Kosari F, Shabani Rad M, Natkunam Y, et al. LMO2 (LIM domain only 2) is expressed in a subset of acute myeloid leukaemia and correlates with normal karyotype. Histopathology. 2014;64:226-33 pubmed publisher
    b>LMO2 is a transcription factor that plays a key role in haematopoiesis...
  65. Jevremovic D, Roden A, Ketterling R, Kurtin P, McPhail E. LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma. Am J Clin Pathol. 2016;145:180-90 pubmed publisher
    ..LIM Domain Only 2 (LMO2) gene translocations have been implicated in the pathogenesis of a small subset of T-ALLs, and LMO2 protein has ..
  66. Tzankov A, Leu N, Muenst S, Juskevicius D, Klingbiel D, Mamot C, et al. Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study. J Hematol Oncol. 2015;8:70 pubmed publisher
    ..Immunohistochemical (bcl2, bcl6, CD5, CD10, CD20, CD95, CD168, cyclin E, FOXP1, GCET, Ki-67, LMO2, MUM1p, pSTAT3) and in situ hybridization analyses (BCL2 break apart probe, C-MYC break apart probe and C-MYC/IGH ..
  67. Dhami P, Bruce A, Jim J, Dillon S, Hall A, Cooper J, et al. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS ONE. 2010;5:e9059 pubmed publisher
    ..They bind a number of haematopoietic transcription factors (GATA1, E2A LMO2, SCL, LDB1), CTCF or components of the transcriptional machinery and are associated with relevant histone ..
  68. Sun W, Shen W, Yang S, Hu F, Gao Y, Qiao Y, et al. Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes. J Biomed Sci. 2010;17:22 pubmed publisher
    The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S...
  69. de Boer J, Yeung J, Ellu J, Ramanujachar R, Bornhauser B, Solarska O, et al. The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors. Leukemia. 2011;25:321-30 pubmed publisher
    ..We identify Lmo2 and Bcl-2 as direct target genes downstream of E2A-HLF...
  70. Zhou S, Fatima S, Ma Z, Wang Y, Lu T, Janke L, et al. Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes. Mol Ther. 2016;24:1090-1099 pubmed publisher
    ..caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus...
  71. Valge Archer V, Osada H, Warren A, Forster A, Li J, Baer R, et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci U S A. 1994;91:8617-21 pubmed
    ..acute leukemias can activate genes encoding putative transcription factors such as the LIM proteins RBTN1 and RBTN2 and the DNA-binding basic helix-loop-helix transcription factor TAL1 associated with T-cell acute lymphocytic ..
  72. Younes S, Beck A, Lossos I, Levy R, Warnke R, Natkunam Y. Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. Am J Surg Pathol. 2010;34:1266-76 pubmed publisher
    ..center B-cell markers, human germinal center associated lymphoma (HGAL), and LIM-only transcription factor 2 (LMO2), in 127 FL patient biopsies (94 nodal, 33 extranodal), and correlated the findings with histologic pattern, ..
  73. Li Q, Yin M, Li Y, Fan C, Yang Q, Wu J, et al. Expression of Brassica napus TTG2, a regulator of trichome development, increases plant sensitivity to salt stress by suppressing the expression of auxin biosynthesis genes. J Exp Bot. 2015;66:5821-36 pubmed publisher
    ..b>TTG2 genes, which are homologous to the Arabidopsis AtTTG2 (WRKY44) gene. Four Bna...
  74. Yu J, Wu Y, Xia S, Zhao F, Zhou G. [Effect of prostate peripheral zones stromal cells on the proliferation of prostate cells by overexpression of LMO2 gene]. Zhonghua Yi Xue Za Zhi. 2016;96:91-4 pubmed publisher
    ..effect of prostate peripheral zones (PZs) stromal cells on the proliferation of prostate cells by overexpression of LMO2 gene. Genes expressional distinction of different prostate stromal cells was screened by gene expression arrays...
  75. Meng S, Matrone G, Lv J, Chen K, Wong W, Cooke J. LIM Domain Only 2 Regulates Endothelial Proliferation, Angiogenesis, and Tissue Regeneration. J Am Heart Assoc. 2016;5: pubmed
    LIM domain only 2 (LMO2, human gene) is a key transcription factor that regulates hematopoiesis and vascular development. However, its role in adult endothelial function has been incompletely characterized...
  76. Coma S, Allard Ratick M, Akino T, van Meeteren L, Mammoto A, Klagsbrun M. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. 2013;16:939-52 pubmed publisher
    GATA-binding protein 2 (GATA2) and LIM domain only 2 (Lmo2) form common transcription complexes during hematopoietic differentiation...
  77. Sotoca A, Prange K, Reijnders B, Mandoli A, Nguyen L, Stunnenberg H, et al. The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia. Oncogene. 2016;35:1965-76 pubmed publisher
    ..Here, we show that FUS-ERG acts in the context of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LMO2, RUNX1 and TAL1) central to proper expression of genes involved in maintaining a stem cell hematopoietic phenotype...
  78. Sincennes M, Humbert M, Grondin B, Lisi V, Veiga D, Haman A, et al. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc Natl Acad Sci U S A. 2016;113:1393-8 pubmed publisher
    ..networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL)...
  79. Efimenko E, DAVE U, Lebedeva I, Shen Y, Sanchez Quintero M, Diolaiti D, et al. PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature. Mol Cancer Ther. 2017;16:2069-2082 pubmed publisher
    ..Using an Lmo2-driven mouse model of T-ALL in which both the PI3K/AKT and NOTCH1 pathways are aberrantly upregulated, we now ..
  80. Bosch M, Akhter A, Chen B, Mansoor A, LeBrun D, Good D, et al. A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma. Haematologica. 2018;103:288-296 pubmed publisher
    ..available to create tissue microarrays and perform immunohistochemistry staining for CD10, BCL6, MUM1/IRF4, FOXP1, LMO2, BCL2, MYC, P53 and phosphoSTAT3 (pySTAT3) expression...
  81. Davenport J, Neale G, Goorha R. Identification of genes potentially involved in LMO2-induced leukemogenesis. Leukemia. 2000;14:1986-96 pubmed
    The most common translocations in childhood T cell acute lymphoblastic leukemias involve the LMO2 locus on chromosome 11p13 and cause ectopic expression of the LMO2 gene in thymocytes...
  82. Lecuyer E, Larivière S, Sincennes M, Haman A, Lahlil R, Todorova M, et al. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem. 2007;282:33649-58 pubmed
    ..The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of transcription factor complexes that are essential for hematopoiesis...
  83. Bianchi E, Zini R, Salati S, Tenedini E, Norfo R, Tagliafico E, et al. c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression. Blood. 2010;116:e99-110 pubmed publisher
    ..CD34(+) cells identified the transcription factors Kruppel-Like Factor 1 (KLF1) and LIM Domain Only 2 (LMO2) as putative targets, which can account for c-myb knockdown effects...
  84. Agostinelli C, Paterson J, Gupta R, Righi S, Sandri F, Piccaluga P, et al. Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody. Histopathology. 2012;61:33-46 pubmed publisher
    ..monoclonal antibody, raised against a fixation-resistant epitope of the transcription regulator LIM domain only 2 (LMO2)...
  85. Kim J, Kim K, Eom G, Choe N, Kee H, Son H, et al. KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia. Mol Cell Biol. 2012;32:2917-33 pubmed publisher
    ..Furthermore, KDM3B displayed histone H3K9-me1/2 demethylase activity and induced leukemogenic oncogene lmo2 expression via a synergistic interaction with CBP...
  86. Wiekmeijer A, Pike Overzet K, Brugman M, van Eggermond M, Cordes M, de Haas E, et al. Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms. Exp Hematol. 2016;44:838-849.e9 pubmed publisher
    Overexpression of LMO2 is known to be one of the causes of T-cell acute lymphoblastic leukemia (T-ALL) development; however, the mechanisms behind its oncogenic activity are incompletely understood...
  87. Mandoli A, Singh A, Prange K, Tijchon E, Oerlemans M, Dirks R, et al. The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs. Cell Rep. 2016;17:2087-2100 pubmed publisher
    ..elements characterized by low acetylation levels and binding of the hematopoietic transcription factors LYL1 and LMO2. In contrast, ERG, FLI1, TAL1, and RUNX1 bind at all AML1-ETO-occupied regulatory regions, including those of the ..
  88. Choi A, Illendula A, Pulikkan J, Roderick J, Tesell J, Yu J, et al. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. Blood. 2017;130:1722-1733 pubmed publisher
    ..To elucidate RUNX1 function(s) in leukemogenesis, we generated Tal1/Lmo2/Rosa26-CreERT2Runx1f/f mice and examined leukemia progression in the ..
  89. Osada H, Grutz G, Axelson H, Forster A, Rabbitts T. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A. 1995;92:9585-9 pubmed
    The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated...
  90. Jurata L, Pfaff S, Gill G. The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. J Biol Chem. 1998;273:3152-7 pubmed
    ..Evidence indicating that NLI facilitates long range enhancer-promoter interactions suggests that NLI-dependent LIM domain transcription factor complexes are involved in communication between transcriptional control elements. ..
  91. Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, et al. Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood. 2010;116:962-70 pubmed publisher
    b>LMO2, a critical transcription regulator of hematopoiesis, is involved in human T-cell leukemia...
  92. Durnick D, Law M, Maurer M, Natkunam Y, Levy R, Lossos I, et al. Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma. Am J Clin Pathol. 2010;134:278-81 pubmed publisher
    ..Therefore, we studied the relationship between expression of the purported germinal center marker LMO2 and the presence of IGH-BCL2 fusions, BCL6 translocations, and LMO2 translocations...