LMO1

Summary

Gene Symbol: LMO1
Description: LIM domain only 1
Alias: RBTN1, RHOM1, TTG1, rhombotin-1, LIM domain only 1 (rhombotin 1), LIM domain only protein 1, LMO-1, T-cell translocation gene 1, T-cell translocation protein 1, cysteine-rich protein TTG-1
Species: human
Products:     LMO1

Top Publications

  1. Wang K, Diskin S, Zhang H, Attiyeh E, Winter C, Hou C, et al. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature. 2011;469:216-20 pubmed publisher
    ..Here we report a significant association within LIM domain only 1 (LMO1) at 11p15.4 (rs110419, combined P = 5.2?×?10(-16), odds ratio of risk allele = 1.34 (95% confidence interval 1...
  2. Boehm T, Foroni L, Kaneko Y, Perutz M, Rabbitts T. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991;88:4367-71 pubmed
    ..The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains. ..
  3. Boehm T, Spillantini M, Sofroniew M, Surani M, Rabbitts T. Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. Oncogene. 1991;6:695-703 pubmed
  4. Beuten J, Gelfond J, Piwkham D, Pollock B, Winick N, Collier A, et al. Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1). Carcinogenesis. 2011;32:1349-53 pubmed publisher
    ..05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P = 3 × 10(-5)]...
  5. Boehm T, Greenberg J, Buluwela L, Lavenir I, Forster A, Rabbitts T. An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. EMBO J. 1990;9:857-68 pubmed
    ..This is, therefore, a new form of eukaryotic gene organization from which similar proteins can be made from distinct mRNA species. ..
  6. McGuire E, Hockett R, Pollock K, Bartholdi M, O Brien S, Korsmeyer S. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol. 1989;9:2124-32 pubmed
    ..4-kilobase transcript (termed Ttg-1 [T-cell translocation gene 1]) from an 8402 library. The predicted protein of 156 amino acids contained two internal repeats which could potentially form zinc fingers. ..
  7. Boehm T, Baer R, Lavenir I, Forster A, Waters J, Nacheva E, et al. The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. EMBO J. 1988;7:385-94 pubmed
  8. Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao X, et al. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. J Mol Biol. 1992;226:747-61 pubmed
    The rhombotin (RBTN1 or Ttg-1) gene was first identified at a chromosome translocation in a T-cell acute leukaemia and later used to isolate two related genes (RBTN2 or Ttg-2 and RBTN3)...
  9. Valge Archer V, Forster A, Rabbitts T. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Oncogene. 1998;17:3199-202 pubmed
    The ectopic expression of LMO1 or LMO2 in T cell acute leukaemias resulting from chromosomal translocations t(11;14)(p15;qll) or t(11;14)(p13;q11) respectively in a causal factor in tumorigenesis...

More Information

Publications80

  1. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    ..In this case, TAL1 and LMO act as cofactors for GATA3 to activate the transcription of RALDH2. ..
  2. Ono Y, Fukuhara N, Yoshie O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem. 1997;272:4576-81 pubmed
    ..b>RBTN1 and RBTN2, also frequently activated in T-ALL, encode proteins only with tandem cysteine-rich LIM domains...
  3. Wang X, Wu H, Gao J, Wang X, Gao T, Zhang S. FGF represses metastasis of neuroblastoma regulated by MYCN and TGF-β1 induced LMO1 via control of let-7 expression. Brain Res. 2019;1704:219-228 pubmed publisher
    MYCN and LMO1 amplification are commonly observed in neuroblastoma (NB), which was often accompanied by genetic loss of let-7 microRNA (miRNA)...
  4. Liang G, He H, Li Y, Ai Q, Yu D. MYB82 functions in regulation of trichome development in Arabidopsis. J Exp Bot. 2014;65:3215-23 pubmed publisher
    Trichome initiation and patterning are controlled by the TTG1-bHLH-MYB regulatory complex. Several MYB transcription factors have been determined to function in trichome development via incorporation into this complex...
  5. Gachet S, El Chaar T, Avran D, Genescà E, Catez F, Quentin S, et al. Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation. Cancer Discov. 2018;8:1614-1631 pubmed publisher
    ..Combined silencing of both genes, but not of either gene alone, accelerated leukemogeneis in a Tal1/Lmo1/Notch1-driven mouse model, demonstrating the tumor-suppressive nature of the two-gene region...
  6. Gerby B, Tremblay C, Tremblay M, Rojas Sutterlin S, Herblot S, Hébert J, et al. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet. 2014;10:e1004768 pubmed publisher
    ..First, thymocytes that are reprogrammed by the SCL and LMO1 oncogenic transcription factors into self-renewing pre-leukemic stem cells (pre-LSCs) remain non-malignant, as ..
  7. Gruber M, Alahakoon U, Taheri A, Nagubushana N, Zhou R, Aung B, et al. The biochemical composition and transcriptome of cotyledons from Brassica napus lines expressing the AtGL3 transcription factor and exhibiting reduced flea beetle feeding. BMC Plant Biol. 2018;18:64 pubmed publisher
    ..thaliana GL3 gene (line AtGL3+) [1] or the AtGL3 gene in combination with an RNAi construct to down-regulate TTG1 (line K-5-8) [2] were developed...
  8. Liu Y, Liu D, Khan A, Liu B, Wu M, Huang L, et al. NbGIS regulates glandular trichome initiation through GA signaling in tobacco. Plant Mol Biol. 2018;98:153-167 pubmed publisher
    ..revealed that a C2H2 zinc-finger transcription factor GIS and its sub-family genes act upstream of GL3/EGL3-GL1-TTG1 transcriptional activator complex to regulate trichome initiation in Arabidopsis...
  9. Truong H, Lee W, Jeong C, Trinh C, Lee S, Kang C, et al. Enhanced anthocyanin accumulation confers increased growth performance in plants under low nitrate and high salt stress conditions owing to active modulation of nitrate metabolism. J Plant Physiol. 2018;231:41-48 pubmed publisher
    ..We used PAP1-D/fls1ko and ttg1 plants which have a perturbed anthocyanin biosynthesis pathway to explore the role of anthocyanin in plant ..
  10. Saeki N, Saito A, Sugaya Y, Amemiya M, Sasaki H. Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma. Cancer Genomics Proteomics. 2018;15:413-420 pubmed publisher
    ..LIM domain only 1 (LMO1) gene encoding a transcriptional regulator is an NB-susceptibility gene with a tumor-promoting activity...
  11. Pesch M, Schultheiß I, Klopffleisch K, Uhrig J, Koegl M, Clemen C, et al. TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis. Plant Physiol. 2015;168:584-97 pubmed publisher
    ..Arabidopsis thaliana) is governed by GLABRA1 (GL1; R2R3MYB), GL3 (bHLH), and transparent TESTA GLABRA1 (TTG1; WD40). They are thought to form a trimeric complex that acts as a transcriptional activation complex...
  12. Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, et al. Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma. Cancer Genomics Proteomics. 2018;15:165-174 pubmed
    ..An integrative genomics study revealed that LIM domain only 1 (LMO1) encoding a transcriptional regulator to be an NB-susceptibility gene with a tumor-promoting activity, that needs ..
  13. Zhu Z, Wang H, Wang Y, Guan S, Wang F, Tang J, et al. Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation. J Exp Bot. 2015;66:3775-89 pubmed publisher
    ..In Ipomoea purpurea, the IpMYB1-IpbHLH2-IpWDR1 (IpMBW) complex was found to be orthologous to the PAP1-GL3-TTG1 (AtPGT) complex of Arabidopsis thaliana, and interacted with a 7-bp MYB-recognizing element (MRE) and a 6-bp bHLH-..
  14. Schmitz H, Jendretzki A, Wittland J, Wiechert J, Heinisch J. Identification of Dck1 and Lmo1 as upstream regulators of the small GTPase Rho5 in Saccharomyces cerevisiae. Mol Microbiol. 2015;96:306-24 pubmed publisher
    ..novel regulators of cell wall integrity signaling, we identified the homologs of mammalian DOCK1 (Dck1) and ELMO (Lmo1) as upstream components which regulate Rho5...
  15. Ranocha P, Francoz E, Burlat V, Dunand C. Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion. Plant Signal Behav. 2014;9:e977734 pubmed publisher
    ..actors (PRX56, DIR12) have been analyzed in T-DNA mutants affected in master TFs (ap2, egl3/gl3, gl2, myb5, tt8, ttg1, ttg2 and luh1/mum1)...
  16. Li F, Sun C, Li X, Yu X, Luo C, Shen Y, et al. The effect of graphene oxide on adventitious root formation and growth in apple. Plant Physiol Biochem. 2018;129:122-129 pubmed publisher
    ..Additionally, the transcript levels of ARRO1, ARF19, and TTG1, which play roles in the formation of adventitious roots, lateral roots, and root hairs, respectively, were all ..
  17. Wei S, Li X, Gruber M, Feyissa B, Amyot L, Hannoufa A. COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis. BMC Plant Biol. 2018;18:134 pubmed publisher
    ..Their production is regulated by a network that includes a TTG1/bHLH/MYB tri-protein complex in Arabidopsis...
  18. Pesch M, Dartan B, Birkenbihl R, Somssich I, Hülskamp M. Arabidopsis TTG2 regulates TRY expression through enhancement of activator complex-triggered activation. Plant Cell. 2014;26:4067-83 pubmed publisher
    ..thaliana is regulated by a regulatory feedback loop of the trichome promoting factors TRANSPARENT TESTA GLABRA1 (TTG1), GLABRA3 (GL3)/ENHANCER OF GL3 (EGL3), and GL1 and a group of homologous R3MYB proteins that act as their ..
  19. Zhou F, Gou S, Xiong J, Wu H, Wang C, Liu T. Oncogenicity of LHX2 in pancreatic ductal adenocarcinoma. Mol Biol Rep. 2014;41:8163-7 pubmed publisher
    ..levels correlated with Lhx2 expression in PDA while the Lhx2 simulated β-catenin activation was required for LMO1's oncogenic effects...
  20. Liu B, Zhu Y, Zhang T. The R3-MYB gene GhCPC negatively regulates cotton fiber elongation. PLoS ONE. 2015;10:e0116272 pubmed publisher
    ..suggested that GhCPC might negatively regulate cotton fiber initiation and early elongation by a potential CPC-MYC1-TTG1/4 complex...
  21. Schmitz H, Jendretzki A, Sterk C, Heinisch J. The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation. Int J Mol Sci. 2018;19: pubmed publisher
    ..plasma membrane to mitochondria upon glucose starvation, mediated by its dimeric GDP/GTP exchange factor (GEF) Dck1/Lmo1. A function in response to glucose availability is also suggested by synthetic genetic phenotypes of a rho5 ..
  22. Liu Y, Hou H, Jiang X, Wang P, Dai X, Chen W, et al. A WD40 Repeat Protein from Camellia sinensis Regulates Anthocyanin and Proanthocyanidin Accumulation through the Formation of MYB⁻bHLH⁻WD40 Ternary Complexes. Int J Mol Sci. 2018;19: pubmed publisher
    ..The overexpression of CsWD40 in Arabidopsis thaliana transparent testa glabra 1 (ttg1) restored normal trichome and seed coat development...
  23. Yu D, Yu F, Du C, Li X, Zhao X, Liu X. RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis. Plant Physiol Biochem. 2015;88:82-8 pubmed publisher
    ..Expression analysis results showed that the transcription levels of ZFP6, ZFP5, GIS, GL1, GL2, GL3, TTG1 and MYB23, which promote trichome initiation, were up-regulated in the rpn1a mutant, and expression of FRC4, which ..
  24. Capasso M, Diskin S, Cimmino F, Acierno G, Totaro F, Petrosino G, et al. Common genetic variants in NEFL influence gene expression and neuroblastoma risk. Cancer Res. 2014;74:6913-24 pubmed publisher
    ..study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma ..
  25. Taheri A, Gao P, Yu M, Cui D, Regan S, Parkin I, et al. A landscape of hairy and twisted: hunting for new trichome mutants in the Saskatoon Arabidopsis T-DNA population. Plant Biol (Stuttg). 2015;17:384-94 pubmed publisher
    ..Alleles of the well-known trichome genes TRY, GL2 and TTG1 were recovered with atypical phenotype variation not reported previously...
  26. Nemie Feyissa D, Heidari B, Blaise M, Lillo C. Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis. Phytochemistry. 2015;111:21-6 pubmed publisher
    ..MBW complexes) with various R2R3 MYB transcription factors and a WD40 repeat protein TRANSPARENT TESTA GLABROUS1 (TTG1)...
  27. Gerby B, Veiga D, Krosl J, Nourreddine S, Ouellette J, Haman A, et al. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. J Clin Invest. 2016;126:4569-4584 pubmed publisher
    ..complexity of primary cells in order to specifically monitor pre-LSCs, which were induced here by the SCL/TAL1 and LMO1 oncogenes...
  28. Porcher C, Chagraoui H, Kristiansen M. SCL/TAL1: a multifaceted regulator from blood development to disease. Blood. 2017;129:2051-2060 pubmed publisher
    ..SCL's activities are all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM domain only 1 or 2]:LDB1 [LIM domain-binding protein 1]) and dynamic recruitment of conserved combinatorial ..
  29. Alahakoon U, Taheri A, Nayidu N, Epp D, Yu M, Parkin I, et al. Hairy Canola (Brasssica napus) re-visited: Down-regulating TTG1 in an AtGL3-enhanced hairy leaf background improves growth, leaf trichome coverage, and metabolite gene expression diversity. BMC Plant Biol. 2016;16:12 pubmed publisher
    ..In Arabidopsis, a network of three classes of proteins consisting of TTG1 (a WD40 repeat protein), GL3 (a bHLH factor) and GL1 (a MYB transcription factor), activates trichome initiation ..
  30. Dhawan S, Shukla P, Gupta P, Lal R. A cold-tolerant evergreen interspecific hybrid of Ocimum kilimandscharicum and Ocimum basilicum: analyzing trichomes and molecular variations. Protoplasma. 2016;253:845-55 pubmed publisher
    ..Gene expression analysis was done in O. basilicum, O. kilimandscharicum and their hybrid for TTG1, GTL1, and STICHEL gene locus which regulates trichome development and its formation and transcription factors WRKY ..
  31. Liu K, Qi S, Li D, Jin C, Gao C, Duan S, et al. TRANSPARENT TESTA GLABRA 1 ubiquitously regulates plant growth and development from Arabidopsis to foxtail millet (Setaria italica). Plant Sci. 2017;254:60-69 pubmed publisher
    ..Overexpression of the SiTTG1 gene rescued many of the mutant phenotypes in Arabidopsis ttg1-13 plants...
  32. Chen Z, Liu G, Tang N, Li Z. Transcriptome Analysis Reveals Molecular Signatures of Luteoloside Accumulation in Senescing Leaves of Lonicera macranthoides. Int J Mol Sci. 2018;19: pubmed publisher
    ..Among these TFs, MYB12, MYB75, bHLH113 and TTG1 were considered to be key factors involved in the regulation of luteoloside biosynthesis...
  33. Verweij W, Spelt C, Bliek M, de Vries M, Wit N, Faraco M, et al. Functionally Similar WRKY Proteins Regulate Vacuolar Acidification in Petunia and Hair Development in Arabidopsis. Plant Cell. 2016;28:786-803 pubmed publisher
    The WD40 proteins ANTHOCYANIN11 (AN11) from petunia (Petunia hybrida) and TRANSPARENT TESTA GLABRA1 (TTG1) from Arabidopsis thaliana and associated basic helix-loop-helix (bHLH) and MYB transcription factors activate a variety of ..
  34. Zhang B, Schrader A. TRANSPARENT TESTA GLABRA 1-Dependent Regulation of Flavonoid Biosynthesis. Plants (Basel). 2017;6: pubmed publisher
    ..We present a comprehensive collection of A. thalianattg1 mutants and AtTTG1 orthologs...
  35. Gonzalez A, Brown M, Hatlestad G, Akhavan N, Smith T, Hembd A, et al. TTG2 controls the developmental regulation of seed coat tannins in Arabidopsis by regulating vacuolar transport steps in the proanthocyanidin pathway. Dev Biol. 2016;419:54-63 pubmed publisher
    ..A transcription factor complex consisting of TT2, TT8 and TTG1 controls expression of PA biosynthetic genes, just as similar TTG1-dependent complexes have been shown to control ..
  36. Chen M, Zhang B, Li C, Kulaveerasingam H, Chew F, Yu H. TRANSPARENT TESTA GLABRA1 Regulates the Accumulation of Seed Storage Reserves in Arabidopsis. Plant Physiol. 2015;169:391-402 pubmed publisher
    ..Here, we show that TRANSPARENT TESTA GLABRA1 (TTG1), which encodes a WD40 repeat transcription factor involved in many aspects of plant development, plays an ..
  37. Ioannidi E, Rigas S, Tsitsekian D, Daras G, Alatzas A, Makris A, et al. Trichome patterning control involves TTG1 interaction with SPL transcription factors. Plant Mol Biol. 2016;92:675-687 pubmed
    ..In Arabidopsis, a ternary complex formed by MYB, bHLH transcription factors and TTG1 modulates unicellular trichome morphogenesis...
  38. Li C, Zhang B, Chen B, Ji L, Yu H. Site-specific phosphorylation of TRANSPARENT TESTA GLABRA1 mediates carbon partitioning in Arabidopsis seeds. Nat Commun. 2018;9:571 pubmed publisher
    ..Here we show that phosphorylation of TRANSPARENT TESTA GLABRA1 (TTG1) is regulated by SHAGGY-like kinases 11/12 (SK11/12) and that this mediates carbon flow to fatty acid synthesis and ..
  39. Mishra A, Lal R, Chanotiya C, Dhawan S. Genetic elaborations of glandular and non-glandular trichomes in Mentha arvensis genotypes: assessing genotypic and phenotypic correlations along with gene expressions. Protoplasma. 2017;254:1045-1061 pubmed publisher
    ..expressions were analyzed for biosynthesis genes and selected transcription factors TRANSPARENT TESTA GLABRA 1 (TTG1), ENOLASE 1, GLABRA 3, GTL 1, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT B-6, WRKY transcription factor 22, putative ..
  40. Hoang T, Lambert J, Martin R. SCL/TAL1 in Hematopoiesis and Cellular Reprogramming. Curr Top Dev Biol. 2016;118:163-204 pubmed publisher
    ..transcription by recruiting a core complex on DNA that necessarily includes E2A/HEB, GATA1-3, LIM-only proteins LMO1/2, LDB1, and an extended complex comprising ETO2, RUNX1, ERG, or FLI1...
  41. Oldridge D, Wood A, Weichert Leahey N, Crimmins I, Sussman R, Winter C, et al. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature. 2015;528:418-21 pubmed publisher
    ..A previous genome-wide association study identified common polymorphisms at the LMO1 gene locus that are highly associated with neuroblastoma susceptibility and oncogenic addiction to LMO1 in the ..
  42. Li Z, Abraham B, Berezovskaya A, Farah N, Liu Y, Leon T, et al. APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia. 2017;31:2057-2064 pubmed publisher
    ..that occurs as a somatic mutation in noncoding sequences 4?kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-cell acute lymphoblastic leukaemia...
  43. Ryder P, McHale M, Fort A, Spillane C. Generation of stable nulliplex autopolyploid lines of Arabidopsis thaliana using CRISPR/Cas9 genome editing. Plant Cell Rep. 2017;36:1005-1008 pubmed publisher
    ..Using CRISPR/Cas9 genome editing to generate knockout alleles of the TTG1 gene, we demonstrate that homozygous nulliplex mutants can be directly generated in tetraploid Arabidopsis thaliana ..
  44. Al Absi B, Razif M, Noor S, Saif Ali R, Aqlan M, Salem S, et al. Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population. Genet Test Mol Biomarkers. 2017;21:592-599 pubmed publisher
    ..2; ID: 10320), DDC (7p12.2; ID: 1644), CDKN2A (9p21.3; ID: 1029), CEBPE (14q11.2; ID: 1053), and LMO1 (11p15; ID: 4004)...
  45. Liu Z, Thiele C. When LMO1 Meets MYCN, Neuroblastoma Is Metastatic. Cancer Cell. 2017;32:273-275 pubmed publisher
    b>LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al...
  46. Jurata L, Kenny D, Gill G. Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A. 1996;93:11693-8 pubmed
    ..The broad range of interactions between NLI and LIM-containing transcription factors suggests the utilization of a common mechanism to impart unique cell fate instructions. ..
  47. Zhang Y, Yang J, Wang J, Guo H, Jing N. LMO1 is a novel oncogene in lung cancer, and its overexpression is a new predictive marker for anti-EGFR therapy. Med Oncol. 2014;31:99 pubmed publisher
    ..We report that one oncogene amplified on chromosome 3q26, LMO1, a master transcriptional regulator of stemness, operates to drive strong growth phenotype in NSCLC...
  48. Arber S, Caroni P. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Genes Dev. 1996;10:289-300 pubmed
    ..On the basis of these findings, we propose that LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes. ..
  49. Karasik D, Hsu Y, Zhou Y, Cupples L, Kiel D, Demissie S. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. J Bone Miner Res. 2010;25:1555-63 pubmed publisher
    ..Most of the similarity between the quantitative bone phenotypes may be attributed to pleiotropic effects of genes. This knowledge may prove helpful in defining the best phenotypes to be used in genetic studies of osteoporosis...
  50. Sang M, Ma L, Sang M, Zhou X, Gao W, Geng C. LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins. Mol Biol Rep. 2014;41:1067-73 pubmed publisher
    ..To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified...
  51. Wadman I, Li J, Bash R, Forster A, Osada H, Rabbitts T, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 1994;13:4831-9 pubmed
    ..b>RBTN1 and RBTN2 encode highly related proteins that possess cysteine-rich LIM motifs...
  52. Chen Q, Cheng J, Tasi L, Schneider N, Buchanan G, Carroll A, et al. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 1990;9:415-24 pubmed
    ..Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes. ..
  53. McGuire E, Davis A, Korsmeyer S. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. Blood. 1991;77:599-606 pubmed
    ..The two potential zinc finger domains in Ttg-1 are highly homologous to similar regions in lin-11, mec-3, and lsl-1. This data suggests that Ttg-1 may be involved in gene regulation. ..
  54. Hungate E, Applebaum M, Skol A, Vaksman Z, Diamond M, McDaniel L, et al. Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..71, Pmeta = .19). SNP rs80059929 is within intron 16 in the KIF15 gene. Additionally, the previously reported LMO1 neuroblastoma risk locus was statistically significant only in patients with MYCN-nonamplified high-risk tumors (OR..
  55. Bao J, Talmage D, Role L, Gautier J. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. Development. 2000;127:425-35 pubmed
    ..We propose that XHEN1, in concert with XLMO-3, is a critical regulator of neurogenesis. ..
  56. Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gerard D, et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med. 2010;207:2141-56 pubmed publisher
    ..Finally, TAL1 or NKX3.1 knockdown abrogates the ability of human T-ALL cells to efficiently induce leukemia development in mice. These results suggest that tumor suppressor or oncogenic activity of NKX3.1 depends on tissue expression. ..
  57. Zhang J, Lin H, Wang J, He J, Zhang D, Qin P, et al. LMO1 polymorphisms reduce neuroblastoma risk in Chinese children: a two-center case-control study. Oncotarget. 2017;8:65620-65626 pubmed publisher
    Previous genome-wide association and validation studies suggest that LIM domain only 1 (LMO1) gene polymorphisms affect neuroblastoma susceptibility...
  58. He J, Zou Y, Wang T, Zhang R, Yang T, Zhu J, et al. Genetic Variations of GWAS-Identified Genes and Neuroblastoma Susceptibility: a Replication Study in Southern Chinese Children. Transl Oncol. 2017;10:936-941 pubmed publisher
    ..We confirmed that CASC15 rs6939340 A>G, rs4712653 T>C, rs9295536 C>A, LIN28B rs221634 A>T, and LMO1 rs110419 A>G were associated with significantly altered neuroblastoma susceptibility...
  59. Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
    A genome-wide association study identified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma...
  60. Kalender Atak Z, Imrichová H, Svetlichnyy D, Hulselmans G, Christiaens V, Reumers J, et al. Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks. Genome Med. 2017;9:80 pubmed publisher
    ..We validated μ-cisTarget by re-analyzing the TAL1 and LMO1 enhancer mutations in T-ALL, and the TERT promoter mutation in melanoma...
  61. He J, Zhong W, Zeng J, Zhu J, Zhang R, Wang F, et al. LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population. Oncotarget. 2016;7:22770-8 pubmed publisher
    ..rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility...
  62. Lu J, Chu P, Wang H, Jin Y, Han S, Han W, et al. Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1. PLoS ONE. 2015;10:e0127856 pubmed publisher
    ..05 level, 11 of which were located in LMO1. After correction for multiple comparisons, only rs204926 in LMO1 remained significantly different between cases ..
  63. Cichutek A, Brueckmann T, Seipel B, Hauser H, Schlaubitz S, Prawitt D, et al. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cytogenet Cell Genet. 2001;93:277-83 pubmed
    ..To date, only single tumor-relevant genes with linkage to this region (e.g. LMO1) have been found suggesting that this region may harbor additional potential disease associated genes...
  64. Saeki N, Kim D, Usui T, Aoyagi K, Tatsuta T, Aoki K, et al. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene. 2007;26:6488-98 pubmed
    ..GSDM has a highly apoptotic activity and its expression is regulated by a transcription factor LIM domain only 1 (LMO1) through a sequence to which Runt-related transcription factor 3 (RUNX3) binds, in a GSDM promoter region...
  65. Liu J, Yan P, Jing N, Yang J. LMO1 is a novel oncogene in colorectal cancer and its overexpression is a new predictive marker for anti-EGFR therapy. Tumour Biol. 2014;35:8161-7 pubmed publisher
    ..We report that one oncogene amplified on chromosome 3q26, LMO1, a master transcriptional regulator of stemness, operates to drive strong growth phenotype in CRC...
  66. Kapoor M, Wang J, Wetherill L, Le N, Bertelsen S, Hinrichs A, et al. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Hum Genet. 2013;132:1141-51 pubmed publisher
    ..performed a meta-analysis with these two GWAS and demonstrated evidence of association in both datasets for the LMO1 (p = 7.2 × 10(-7)) and PLCL1 genes (p = 4.1 × 10(-6)) with maxdrinks...
  67. Oram S, Thoms J, Sive J, Calero Nieto F, Kinston S, Schütte J, et al. Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia. Leukemia. 2013;27:1348-57 pubmed publisher
    b>LMO1 is a transcriptional regulator and a T-acute lymphoblastic leukaemia (T-ALL) oncogene...
  68. Diskin S, Capasso M, Schnepp R, Cole K, Attiyeh E, Hou C, et al. Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet. 2012;44:1126-30 pubmed publisher
    ..008 and 0.014, respectively). Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression...
  69. Gu H, Liu T, Cai X, Tong Y, Li Y, Wang C, et al. Upregulated LMO1 in prostate cancer acts as a novel coactivator of the androgen receptor. Int J Oncol. 2015;47:2181-7 pubmed publisher
    b>LMO1, a nuclear transcription coregulator, is implicated in the pathogenesis of T-cell acute lymphoblastic leukemia and neuroblastoma. However, the role of LMO1 in human prostate cancer (PCa) is still unknown...
  70. Lin Y, Deveney R, Barbara M, Iscove N, Nimer S, Slape C, et al. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Cancer Res. 2005;65:7151-8 pubmed
    ..However, almost 60% of transgenic mice that overexpressed both OLIG2 and LMO1 developed pre-T LBL with large thymic tumor masses...
  71. Valge Archer V, Osada H, Warren A, Forster A, Li J, Baer R, et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci U S A. 1994;91:8617-21 pubmed
    ..in T-cell acute leukemias can activate genes encoding putative transcription factors such as the LIM proteins RBTN1 and RBTN2 and the DNA-binding basic helix-loop-helix transcription factor TAL1 associated with T-cell acute ..