Gene Symbol: LMNB2
Description: lamin B2
Alias: EPM9, LAMB2, LMN2, lamin-B2, lamin B3
Species: human
Products:     LMNB2

Top Publications

  1. Méndez López I, Blanco Luquin I, Sánchez Ruiz de Gordoa J, Urdánoz Casado A, Roldán M, Acha B, et al. Hippocampal LMNA Gene Expression is Increased in Late-Stage Alzheimer's Disease. Int J Mol Sci. 2019;20: pubmed publisher
    ..i>LMNA, LMNB1, and LMNB2 genes showed moderate mRNA levels in the human hippocampus with highest expression for the LMNA gene...
  2. Sharief S, Hefni N, Alzahrani W, Nazer I, Bayazeed M, Alhasan K, et al. Genetics of congenital and infantile nephrotic syndrome. World J Pediatr. 2019;15:198-203 pubmed publisher
    ..An underlying causative homozygous mutation was detected in 18 children (90%): NPHS1 (9), NPHS2(2), LAMB2(3), PLCE1(1), WT1(1), and ITSN1 novel mutation (2)...
  3. Li G, Cao Q, Shen Q, Sun L, Zhai Y, Liu H, et al. Gene mutation analysis in 12 Chinese children with congenital nephrotic syndrome. BMC Nephrol. 2018;19:382 pubmed publisher
    ..A mutational analysis was performed in six children by Sanger sequencing in eight genes (NPHS1, NPHS2, PLCE1, WT1, LAMB2, LMXIB, COQ6 and COQ2) before 2014, and whole-exome sequencing was used from 2014 to 2016 in another six children...
  4. Li X, Zhang S, Chiu A, Lo L, To J, Cui H, et al. Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. G3 (Bethesda). 2019;9:297-303 pubmed publisher
    ..i>Agrn), dystrophin, muscular dystrophy (Dmd), laminin, beta 2 (Lamb2) and dystroglycan 1 (Dag1) were also downregulated...
  5. Arima M, Tsukamoto S, Akiyama R, Nishiyama K, Kohno R, Tachibana T, et al. Ocular findings in a case of Pierson syndrome with a novel mutation in laminin ß2 gene. J AAPOS. 2018;22:401-403.e1 pubmed publisher
    Pierson syndrome, an autosomal recessive disorder caused by a mutation in laminin ß2 (LAMB2) gene, is characterized by congenital nephrotic syndrome and various ocular abnormalities...
  6. Deng W, Yan M, Yu T, Ge H, Lin H, Li J, et al. Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer. Cell Physiol Biochem. 2015;35:1677-88 pubmed publisher
    ..and GSN) and the down-regulated levels of expression four of the 50 proteins with down-regulated expression (LMNB2, UHRF1, G3BP1, and HNRNPU) were verified using western blotting...
  7. Eichinger A, Ponsel S, Bergmann C, Günthner R, Hoefele J, Amann K, et al. Cyclosporine A responsive congenital nephrotic syndrome with single heterozygous variants in NPHS1, NPHS2, and PLCE1. Pediatr Nephrol. 2018;33:1269-1272 pubmed publisher
    ..due to changes in five different genes: the nephrin (NPHS1), podocin (NPHS2), Wilms tumor 1 (WT1), laminin ß2 (LAMB2), and phospholipase C epsilon 1 (PLCE1, NPHS3) gene...
  8. Zhuang H, Tan M, Liu J, Hu Z, Liu D, Gao J, et al. Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. Mol Cancer. 2014;13:243 pubmed publisher
    ..downregulated the expression of MAPK and the FOCAL adhesion signaling pathway-associated molecules MKNK2 and LAMB2, and HE4 protein supplementation reversed this effect...
  9. Funk S, Lin M, Miner J. Alport syndrome and Pierson syndrome: Diseases of the glomerular basement membrane. Matrix Biol. 2018;71-72:250-261 pubmed publisher
    ..Mutations in LAMB2 that impact the synthesis or function of laminin α5β2γ1 (LM-521) cause Pierson syndrome (congenital nephrotic ..

More Information


  1. Lee J, Jung H, Fong L, Young S. Do lamin B1 and lamin B2 have redundant functions?. Nucleus. 2014;5:287-92 pubmed publisher
    ..knock-in mice" (knock-in mice that produce lamin B1 from the Lmnb2 locus and knock-in mice that produce lamin B2 from the Lmnb1 locus)...
  2. Park S, Kim Y, CHEN Y. Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology. Pediatr Nephrol. 2018;: pubmed publisher
    ..Mutations in nephrin (NPHS1), podocin (NPHS2), laminin β2 (LAMB2), and α-actinin-4 (ACTN4) have been shown to induce ER stress in HEK293 cells and podocytes in hereditary ..
  3. Misono S, Seki N, Mizuno K, Yamada Y, Uchida A, Arai T, et al. Dual strands of the miR-145 duplex (miR-145-5p and miR-145-3p) regulate oncogenes in lung adenocarcinoma pathogenesis. J Hum Genet. 2018;63:1015-1028 pubmed publisher
    ..In LUAD cells, we identified four possible target genes (LMNB2, NLN, SIX4, and DDC) that might be regulated by both strands of miR-145...
  4. Nanayakkara S, Senevirathna S, Parahitiyawa N, Abeysekera T, Chandrajith R, Ratnatunga N, et al. Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka. Environ Health Prev Med. 2015;20:354-9 pubmed publisher
    ..74. Four rare variants were identified in gene encoding Laminin beta2 (LAMB2) which is known to cause congenital nephrotic syndrome...
  5. Chiang K, Yang H, Pan W. A Two-Stage Whole-Genome Gene Expression Association Study of Young-Onset Hypertension in Han Chinese Population of Taiwan. Sci Rep. 2018;8:1800 pubmed publisher
    ..05). Among these genes, ZRANB1, FAM110A, PREP, ANKRD9 and LAMB2 were also differentially expressed in an existing database of hypertensive mouse model (GSE19817)...
  6. Akinci B, Onay H, Demir T, Savas Erdeve Å, Gen R, Simsir I, et al. Clinical presentations, metabolic abnormalities and end-organ complications in patients with familial partial lipodystrophy. Metabolism. 2017;72:109-119 pubmed publisher
    ..H477L pathogenic variant in one family. A non-pathogenic exon 5 p.R215Q variant of the LMNB2 gene was detected in another family. Five other families harbored no mutation in any of the genes sequenced...
  7. Suvanto M, Patrakka J, Jahnukainen T, Sjöström P, Nuutinen M, Arikoski P, et al. Novel NPHS2 variant in patients with familial steroid-resistant nephrotic syndrome with early onset, slow progression and dominant inheritance pattern. Clin Exp Nephrol. 2017;21:677-684 pubmed publisher
    ..We analyzed SRNS-related genes NPHS1, NPHS2, NEPH1, ACTN4, TRPC6, INF2, WT1, CD2AP, LAMB2, and PLCE1 for disease-causing variants using direct sequencing of exons and intron/exon boundaries in all members ..
  8. Engel A. Genetic basis and phenotypic features of congenital myasthenic syndromes. Handb Clin Neurol. 2018;148:565-589 pubmed publisher
    ..Other less frequently identified disease genes include LAMB2, AGRN, LRP4, MUSK, GFPT1, DPAGT1, ALG2, and ALG 14 as well as SCN4A, PREPL, PLEC1, DNM2, and MTM1...
  9. Lin M, Miller J, Kikkawa Y, Suleiman H, Tryggvason K, Hodges B, et al. Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome. J Am Soc Nephrol. 2018;29:1426-1436 pubmed publisher
    b>Background Laminin ?5?2?1 (LM-521) is a major component of the GBM. Mutations in LAMB2 that prevent LM-521 synthesis and/or secretion cause Pierson syndrome, a rare congenital nephrotic syndrome with ..
  10. Falix F, Bennebroek C, van der Zwaag B, Lapid Gortzak R, Florquin S, Oosterveld M. A novel mutation of laminin ?2 (LAMB2) in two siblings with renal failure. Eur J Pediatr. 2017;176:515-519 pubmed publisher
    This report describes a novel mutation of LAMB2, the gene associated with Pierson syndrome (microcoria-congenital nephrosis syndrome), in two female siblings. The c.970T>C p...
  11. Zhang H, Cui J, Wang F, Xiao H, Ding J, Yao Y. LAMB2 mutation with different phenotypes in China?. Clin Nephrol. 2017;87 (2017):33-38 pubmed
    Mutations of the LAMB2 gene mainly cause Pierson syndrome (OMIM) #609049), characterized by congenital nephrotic syndrome (CNS) and complex ocular involvements with microcoria as the most prominent clinical feature...
  12. McKee K, Aleksandrova M, Yurchenco P. Chimeric protein identification of dystrophic, Pierson and other laminin polymerization residues. Matrix Biol. 2018;67:32-46 pubmed publisher
    ..Several mutations in the LN domains cause LAMA2-deficient muscular dystrophy and LAMB2-deficient Pierson syndrome. These mutations may affect polymerization...
  13. Cosker K, Fenstermacher S, Pazyra Murphy M, Elliott H, Segal R. The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability. Nat Neurosci. 2016;19:690-6 pubmed publisher
    ..Notably, SFPQ is required for coassembly of LaminB2 (Lmnb2) and Bclw (Bcl2l2) mRNAs in RNA granules and for axonal trafficking of these mRNAs...
  14. Wang Y, Dang X, He Q, Zhen Y, He X, Yi Z, et al. Mutation spectrum of genes associated with steroid-resistant nephrotic syndrome in Chinese children. Gene. 2017;625:15-20 pubmed publisher
    ..Eight novel variants were identified, including two in NPHS1, two in PLCE1, one in NPHS2, LAMB2, COL4A3, and COL4A4, respectively. 55...
  15. Wagner J, Chavakis E, Rogg E, Muhly Reinholz M, Glaser S, Günther S, et al. Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:1170-1177 pubmed publisher
    ..genes encoding extracellular matrix proteins, specifically the laminin β1 (Lamb1) and laminin β2 (Lamb2) chains...
  16. Wu Z, Li S, Liu J, Shi Y, Wang J, Chen D, et al. RNAi-mediated silencing of AQP1 expression inhibited the proliferation, invasion and tumorigenesis of osteosarcoma cells. Cancer Biol Ther. 2015;16:1332-40 pubmed publisher
    ..real time PCR and western blot analysis revealed that expression of TGF-β1/TGF-β2, RhoA and laminin β 2 (LAMB2) was remarkably impaired by AQP1 silencing...
  17. Kino J, Tsukaguchi H, Kimata T, Nguyen H, Nakano Y, Miyake N, et al. Nephron development and extrarenal features in a child with congenital nephrotic syndrome caused by null LAMB2 mutations. BMC Nephrol. 2017;18:220 pubmed publisher
    ..Whole-exome sequencing revealed that the affected child was compound heterozygous for novel truncating LAMB2 mutations: a 4-bp insertion (p.Gly1693Alafs*8) and a splicing donor-site substitution (c...
  18. Funk S, Bayer R, Malone A, McKee K, Yurchenco P, Miner J. Pathogenicity of a Human Laminin β2 Mutation Revealed in Models of Alport Syndrome. J Am Soc Nephrol. 2018;29:949-960 pubmed publisher
    ..is a congenital nephrotic syndrome with eye and neurologic defects caused by mutations in laminin β2 (LAMB2), a major component of the glomerular basement membrane (GBM)...
  19. Büscher A, Celebi N, Hoyer P, Klein H, Weber S, Hoefele J. Mutations in INF2 may be associated with renal histology other than focal segmental glomerulosclerosis. Pediatr Nephrol. 2018;33:433-437 pubmed publisher
    ..We performed mutational analysis of ACTN4, CD2AP, COQ6, INF2, LAMB2, NPHS1, NPHS2, PLCE1, TRPC6, and WT1 in the index patient by next-generation sequencing...
  20. Wang J, Mao J. The etiology of congenital nephrotic syndrome: current status and challenges. World J Pediatr. 2016;12:149-58 pubmed publisher
    ..have been identified for their involvements in the pathogenesis of CNS, including NPHS1, NPHS2, WT1, PLCE1, and LAMB2. We searched databases such as PubMed, Elsevier and Wanfang with the following key words: congenital nephrotic ..
  21. Qiu L, Zhou J. Simultaneous mutations of LAMB2 and NPHP1genes in a Chinese girl with isolated congenital nephrotic syndrome: a case report. BMC Pediatr. 2016;16:44 pubmed publisher
    b>LAMB2 mutations cause Pierson syndrome (OMIM 609049), an autosomal recessive genetic disease typically characterized by congenital nephrotic syndrome (CNS) and early onset renal failure, as well as bilateral microcoria...
  22. CHEN Y, Miner J. Glomerular basement membrane and related glomerular disease. Transl Res. 2012;160:291-7 pubmed publisher
    ..Mutations in genes encoding LAMB2, COL4A3, COL4A4, and COL4A5 cause glomerular disease in humans as well as in mice...
  23. Ma Y, Fei L, Zhang M, Zhang W, Liu X, Wang C, et al. Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis. Oncotarget. 2017;8:104813-104830 pubmed publisher
    We investigated the role of lamin B2 in non-small cell lung cancer (NSCLC). We detected higher lamin B2 expression in 20 NSCLC tumor tissues obtained from The Cancer Genome Atlas than in adjacent normal lung tissues...
  24. Zemrani B, Cachat F, Bonny O, Giannoni E, Durig J, Fellmann F, et al. A novel LAMB2 gene mutation associated with a severe phenotype in a neonate with Pierson syndrome. Eur J Med Res. 2016;21:19 pubmed publisher
    Pierson syndrome (PS) is a rare autosomal recessive disorder, caused by mutations in the laminin ?2 (LAMB2) gene. It is characterized by congenital nephrotic syndrome, microcoria, and neurodevelopmental deficits...
  25. CHEN Y, Liapis H. Focal segmental glomerulosclerosis: molecular genetics and targeted therapies. BMC Nephrol. 2015;16:101 pubmed publisher
    ..FSGS) is a primary podocytopathy caused by podocyte-specific gene mutations including NPHS1, NPHS2, WT-1, LAMB2, CD2AP, TRPC6, ACTN4 and INF2...
  26. Elkhatib R, Longepied G, Paci M, Achard V, Grillo J, Levy N, et al. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015;21:225-36 pubmed publisher
    ..is composed of the ubiquitous lamin B1 and the spermatid-specific lamin B3, an N-terminally truncated isoform of lamin B2. However, nothing is known about the NL in human spermatids...
  27. Kapinos L, Schumacher J, Mücke N, Machaidze G, Burkhard P, Aebi U, et al. Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 "half-minilamin" dimers. J Mol Biol. 2010;396:719-31 pubmed publisher
    ..6-1.8 S) indicating the formation of coiled-coil dimers. The smaller carboxy-terminal fragments were, except for lamin B2, largely insoluble under these conditions...
  28. Schirmer E, Gerace L. The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. J Biol Chem. 2004;279:42811-7 pubmed
    ..We find that homotypic and heterotypic binding interactions of lamin B2 are substantially less resistant to chemical dissociation in vitro than those between the other lamin subtypes, ..
  29. Paixão S, Colaluca I, Cubells M, Peverali F, Destro A, Giadrossi S, et al. Modular structure of the human lamin B2 replicator. Mol Cell Biol. 2004;24:2958-67 pubmed
    ..we report a thorough characterization of the DNA sequence requirements of the origin associated with the human lamin B2 gene. A 1...
  30. Abdouh M, Hanna R, El Hajjar J, Flamier A, Bernier G. The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells. J Biol Chem. 2016;291:182-97 pubmed publisher
    ..These observations suggest a dynamic and developmentally regulated model of PRC1 occupancy at constitutive heterochromatin, and where BMI1 function in somatic cells is to stabilize the repetitive genome. ..
  31. Muller W, Wenger R, Reuter P, Renneisen K, Schroder H. Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells. Biochim Biophys Acta. 1989;1008:208-12 pubmed
    ..This could be prevented by coincubation with Zn2+ or Cu2+ (but not Mg2+), which stabilize the mRNA containing nuclear matrix structure. ..
  32. de Noronha C, Sherman M, Lin H, Cavrois M, Moir R, Goldman R, et al. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 2001;294:1105-8 pubmed
    ..Intermittently, these herniations ruptured, resulting in the mixing of nuclear and cytoplasmic components. These Vpr-induced NE changes probably contribute to the observed cell-cycle arrest. ..
  33. Lehner C, Furstenberger G, Eppenberger H, Nigg E. Biogenesis of the nuclear lamina: in vivo synthesis and processing of nuclear protein precursors. Proc Natl Acad Sci U S A. 1986;83:2096-9 pubmed
    ..t 1/2 approximately equal to 3 min) accompanying the mature-size protein was also detected in the case of lamin B2 biosynthesis, but no precursor was found for lamin B1...
  34. Biamonti G, Giacca M, Perini G, Contreas G, Zentilin L, Weighardt F, et al. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. Mol Cell Biol. 1992;12:3499-506 pubmed
    ..cDNAs permitted identification of two genes, one of which encoded a B-type human lamin (analogous to mouse lamin B2). L30E DNA was mapped by in situ hybridization at the G-negative subtelomeric band p13.3 of chromosome 19...
  35. Ranade D, Koul S, Thompson J, Prasad K, Sengupta K. Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus. Chromosoma. 2017;126:223-244 pubmed publisher
    ..Here, we show using whole-genome expression profiling that Lamin A/C or Lamin B2 depletion in an otherwise diploid colorectal cancer cell line (DLD1) deregulates transcript levels from specific ..
  36. Abdurashidova G, Radulescu S, Sandoval O, Zahariev S, Danailov M, Demidovich A, et al. Functional interactions of DNA topoisomerases with a human replication origin. EMBO J. 2007;26:998-1009 pubmed
    The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner...
  37. Maraldi N, Capanni C, Cenni V, Fini M, Lattanzi G. Laminopathies and lamin-associated signaling pathways. J Cell Biochem. 2011;112:979-92 pubmed publisher
    ..Lamin-binding proteins implicated in laminopathies include lamin B2, nuclear envelope proteins such as emerin, MAN1, LBR, and nesprins, the nuclear matrix protein matrin 3, the ..
  38. Kusic J, Kojic S, Divac A, Stefanovic D. Noncanonical DNA elements in the lamin B2 origin of DNA replication. J Biol Chem. 2005;280:9848-54 pubmed
    ..Here we report that the lamin B2 origin of DNA replication adopts an alternative form characterized by unpaired regions CTTTTTTTTTTCC/..
  39. Beaufils C, Farlay D, Machuca Gayet I, Fassier A, Zenker M, Freychet C, et al. Skeletal impairment in Pierson syndrome: Is there a role for laminin?2 in bone physiology?. Bone. 2018;106:187-193 pubmed publisher
    Pierson syndrome is caused by a mutation of LAMB2, encoding for laminin ?2. Clinical phenotype is variable but usually associates congenital nephrotic syndrome (CNS) and ocular abnormalities...
  40. Adam S, Butin Israeli V, Cleland M, Shimi T, Goldman R. Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors. Nucleus. 2013;4:142-50 pubmed publisher
    Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and carboxymethylation...
  41. Muller W, Okamoto T, Reuter P, Ugarkovic D, Schroder H. Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix. J Biol Chem. 1990;265:3803-8 pubmed
    ..Present studies indicate that Tat may function as a linker by binding of nascent HIV RNAs to the nuclear matrix. ..
  42. Jang S, Kim C, Kim J, Choi K. Transcriptional regulatory network of SOX4 during myoblast differentiation. Biochem Biophys Res Commun. 2015;462:365-70 pubmed publisher
    ..b>Lamin B2, barrier to autointegration factor 1, and apolipoprotein C-III were identified as novel interacting partners of ..
  43. Furukawa K, Kondo T. Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin. Eur J Biochem. 1998;251:729-33 pubmed
    ..We found that amino acids in the region of residues 78-258 of the lamin B1 rod domain directly bound with LAP2. The data suggest that LAP2 may modulate the assembly of nuclear lamins. ..
  44. Vodicka M, Koepp D, Silver P, Emerman M. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev. 1998;12:175-85 pubmed
    ..Our data suggest Vpr functionally resembles importin-beta in nuclear import of the HIV-1 pre-integration complex and this function is essential for the role of Vpr in macrophage infection, but not G2 arrest. ..
  45. Worman H, Courvalin J. The inner nuclear membrane. J Membr Biol. 2000;177:1-11 pubmed
  46. Gruenbaum Y, Wilson K, Harel A, Goldberg M, Cohen M. Review: nuclear lamins--structural proteins with fundamental functions. J Struct Biol. 2000;129:313-23 pubmed
    ..In this review, we discuss the roles of the nuclear lamina in DNA replication and apoptosis and analyze how mutations in nuclear lamina proteins might cause genetic diseases. ..
  47. Gao J, Li Y, Fu X, Luo X. A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene. J Pediatr Endocrinol Metab. 2012;25:375-7 pubmed
    ..The etiology of APL is unknown. It may be caused by mutations in the lamin B 2 (LMNB2) gene on 19p13.3. We present a Chinese patient who hadAPL for 12 years, which initially affected her face...
  48. Kill I, Hutchison C. S-phase phosphorylation of lamin B2. FEBS Lett. 1995;377:26-30 pubmed
    b>Lamin B2 modification in synchronously dividing populations of human diploid fibroblasts was determined by 2-dimensional gel electrophoresis and [32P]orthophosphate labelling...
  49. Schumacher J, Reichenzeller M, Kempf T, Schnolzer M, Herrmann H. Identification of a novel, highly variable amino-terminal amino acid sequence element in the nuclear intermediate filament protein lamin B(2) from higher vertebrates. FEBS Lett. 2006;580:6211-6 pubmed
  50. Hegele R, Cao H, Liu D, Costain G, Charlton Menys V, Rodger N, et al. Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy. Am J Hum Genet. 2006;79:383-9 pubmed
    ..Because it also encodes a nuclear lamina protein (lamin B2) and its genomic structure was recently reannotated, we sequenced LMNB2 as a candidate gene in nine white ..
  51. de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali F, Riva S, et al. Selection of homeotic proteins for binding to a human DNA replication origin. J Mol Biol. 2000;299:667-80 pubmed
    ..complex assembles in vivo on a 74 bp sequence within the human DNA replication origin associated to the Lamin B2 gene...
  52. Kasahara K, Chida K, Tsunenaga M, Kohno Y, Ikuta T, Kuroki T. Identification of lamin B2 as a substrate of protein kinase C in BALB/MK-2 mouse keratinocytes. J Biol Chem. 1991;266:20018-23 pubmed
    ..The lamin B fraction consists of lamin B1 and lamin B2. Evidence that p70 is lamin B2 was obtained by peptide mapping and amino acid sequencing...
  53. Damiano J, Afawi Z, Bahlo M, Mauermann M, Misk A, Arsov T, et al. Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia. Hum Mol Genet. 2015;24:4483-90 pubmed publisher
    ..The p.His157Tyr mutation is located in an evolutionarily highly conserved region of the alpha-helical rod of the lamin B2 protein...
  54. Venables R, McLean S, Luny D, Moteleb E, Morley S, Quinlan R, et al. Expression of individual lamins in basal cell carcinomas of the skin. Br J Cancer. 2001;84:512-9 pubmed
    ..Lamin B1 was expressed in all epithelial cells but was not expressed in dermal fibroblasts. Finally, lamin B2 was expressed in all epithelial cells but was not expressed in dermal fibroblasts...
  55. Abdurashidova G, Danailov M, Ochem A, Triolo G, Djeliova V, Radulescu S, et al. Localization of proteins bound to a replication origin of human DNA along the cell cycle. EMBO J. 2003;22:4294-303 pubmed
    The proteins bound in vivo at the human lamin B2 DNA replication origin and their precise sites of binding were investigated along the cell cycle utilizing two novel procedures based on immunoprecipitation following UV irradiation with a ..
  56. Biamonti G, Perini G, Weighardt F, Riva S, Giacca M, Norio P, et al. A human DNA replication origin: localization and transcriptional characterization. Chromosoma. 1992;102:S24-31 pubmed
    ..region containing at least two closely spaced genes with the same polarity of transcription, one encoding lamin B2 and the other an unidentified protein...
  57. Sibani S, Price G, Zannis Hadjopoulos M. Ku80 binds to human replication origins prior to the assembly of the ORC complex. Biochemistry. 2005;44:7885-96 pubmed
    ..ChIP) experiments, using cells synchronized to late G1, showed that the association of Ku80 with the lamin B2, beta-globin, and c-myc origins in vivo was decreased by 1.5-, 2.3-, and 2.5-fold, respectively, in Ku80+/- cells...
  58. Tsai M, Wang S, Heidinger J, Shumaker D, Adam S, Goldman R, et al. A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science. 2006;311:1887-93 pubmed
    ..We propose that lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubule assembly and organization in mitosis. ..
  59. Guler S, Cimen S, Acott P, Whelan K, Molinari M. Kidney transplantation in a child with Pierson syndrome. Pediatr Transplant. 2017;21: pubmed publisher
    ..Consequently, patients become renal replacement therapy dependent. Mutation of the LAMB2 gene is associated with Pierson syndrome, which is an autosomal recessive disorder characterized by congenital ..
  60. Bender H, Werner C, Greuel H, Timp P. [Vulvar neoplasms and preoperative lymphography]. Fortschr Med. 1977;95:2645-52 pubmed
  61. Broers J, Machiels B, Kuijpers H, Smedts F, van den Kieboom R, Raymond Y, et al. A- and B-type lamins are differentially expressed in normal human tissues. Histochem Cell Biol. 1997;107:505-17 pubmed
    ..The lamin B2 antibodies appeared to decorate the nuclear lamina in all tissues examined, except hepatocytes, in which very ..
  62. Hunter D, Manglapus M, Bachay G, Claudepierre T, Dolan M, Gesuelli K, et al. CNS synapses are stabilized trans-synaptically by laminins and laminin-interacting proteins. J Comp Neurol. 2017;: pubmed publisher
    ..Mice with a targeted deletion of the laminin ?2 gene (Lamb2) exhibit retinal disruptions: photoreceptor synapses in the OPL are disorganized and the retinal physiological ..
  63. Stefanovic D, Stanojcic S, Vindigni A, Ochem A, Falaschi A. In vitro protein-DNA interactions at the human lamin B2 replication origin. J Biol Chem. 2003;278:42737-43 pubmed
    ..We approached this problem by utilizing the human lamin B2 origin, wherein the precise start sites of replication initiation have been identified and known to be bound in ..
  64. Kaspi E, Frankel D, Guinde J, Perrin S, Laroumagne S, Robaglia Schlupp A, et al. Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status. PLoS ONE. 2017;12:e0183136 pubmed publisher
    ..Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2. The alternative splicing of LMNA produces two major A-type lamins, lamin A and lamin C...
  65. Biswas S, Bachay G, Chu J, Hunter D, Brunken W. Laminin-Dependent Interaction between Astrocytes and Microglia: A Role in Retinal Angiogenesis. Am J Pathol. 2017;187:2112-2127 pubmed publisher
    ..The reverse effects were seen in the Lamb2-/- retina...
  66. Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015;527:105-9 pubmed publisher
    ..Our study suggests that this new function of autophagy acts as a guarding mechanism protecting cells from tumorigenesis. ..