Gene Symbol: LMAN1
Description: lectin, mannose binding 1
Alias: ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein, endoplasmic reticulum-golgi intermediate compartment protein 53, intracellular mannose-specific lectin MR60
Species: human
Products:     LMAN1

Top Publications

  1. Villarreal J, Crosdale D, Ollier W, Hajeer A, Thomson W, Ordi J, et al. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. Rheumatology (Oxford). 2001;40:1009-12 pubmed
    ..Differences between controls and patients were not significant when considering the FcgammaRIIa polymorphisms; similar results were observed for renal affectation. ..
  2. Fu Y, Zhang B, Mu T. LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors. Biochem Biophys Res Commun. 2019;511:356-362 pubmed publisher
    The endoplasmic reticulum-Golgi intermediate compartment protein-53 (ERGIC-53, aka LMAN1), which cycles between the endoplasmic reticulum (ER) and Golgi, is a known cargo receptor for a number of soluble proteins...
  3. Hantan D, Yamamoto Y, Sakisaka T. VAP-B binds to Rab3GAP1 at the ER: its implication in nuclear envelope formation through the ER-Golgi intermediate compartment. Kobe J Med Sci. 2014;60:E48-56 pubmed
    ..These results suggest that the binding of VAP-B to Rab3GAP1 is implicated in the regulation of nuclear envelope formation through ERGIC. ..
  4. Giannone C, Fagioli C, Valetti C, Sitia R, Anelli T. Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway. Sci Rep. 2017;7:41815 pubmed publisher
    ..These results suggest that the two C-terminal Ig-μ glycans shape the polymerization-dependent aggregation by engaging lectins and acting as spacers in the alignment of individual IgM subunits in native polymers. ..
  5. Gregory L, Thielens N, Matsushita M, Sorensen R, Arlaud G, Fontecilla Camps J, et al. The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J Biol Chem. 2004;279:29391-7 pubmed
    ..These mutations map a common binding site for these proteins located at the distal end of each CUB1 module and stabilized by the Ca(2+) ion. ..
  6. Nie C, Wang H, Wang R, Ginsburg D, Chen X. Dimeric sorting code for concentrative cargo selection by the COPII coat. Proc Natl Acad Sci U S A. 2018;115:E3155-E3162 pubmed publisher
    ..the COPII coat undergoes a dynamic cycle of engagement-disengagement with the transmembrane cargo receptor LMAN1/ERGIC53. LMAN1 undergoes a process of concentrative sorting by the COPII coat, via a dimeric sorting code generated by ..
  7. Sun Y, Shestakova A, Hunt L, Sehgal S, Lupashin V, Storrie B. Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. Mol Biol Cell. 2007;18:4129-42 pubmed
    ..ZW10 depletion resulted in a central, disconnected cluster of Golgi elements and inhibition of ERGIC53 and Golgi enzyme recycling to ER...
  8. Zheng C, Page R, Das V, Nix J, Wigren E, Misra S, et al. Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII). J Biol Chem. 2013;288:20499-509 pubmed publisher
    b>LMAN1 (ERGIC-53) is a key mammalian cargo receptor responsible for the export of a subset of glycoproteins from the endoplasmic reticulum...
  9. Fukamachi M, Kasamatsu A, Endo Sakamoto Y, Fushimi K, Kasama H, Iyoda M, et al. Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer. Exp Cell Res. 2018;368:119-125 pubmed publisher
    Multiple coagulation factor deficiency protein 2 (MCFD2), a binding partner of lectin mannose binding 1 (LMAN1), causes combined deficiencies of coagulation factors V and VIII...

More Information


  1. Galgano D, Onnis A, Pappalardo E, Galvagni F, Acuto O, Baldari C. The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci. 2017;130:1110-1121 pubmed publisher
    ..complex subunit-3 (ARPC3), COP9 signalosome subunit-1 (CSN1, also known as GPS1) and ERGIC-53 (also known as LMAN1). A direct interaction between IFT20 and both IFT54 and GMAP-210 was confirmed in pulldown assays...
  2. Dai Y, Wang Y, Zhao L, Qin Z, Yuan J, Qin Q, et al. A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii). Fish Shellfish Immunol. 2016;55:48-55 pubmed publisher
    ..Our results suggest that PcL-lectin may be required for the multiplication of WSSV, and will pave a new way for the developing of strategies against WSSV infection. ..
  3. Raote I, Ortega Bellido M, Pirozzi M, Zhang C, Melville D, Parashuraman S, et al. TANGO1 assembles into rings around COPII coats at ER exit sites. J Cell Biol. 2017;216:901-909 pubmed publisher
    ..TANGO1 remains at the neck of the newly forming transport carrier, which grows in size by addition of ERGIC-53-containing membranes to generate a transport intermediate for the export of bulky collagens. ..
  4. Mitrovic S, Ben Tekaya H, Koegler E, Gruenberg J, Hauri H. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mol Biol Cell. 2008;19:1976-90 pubmed publisher
    ..These findings imply that cargo receptors are essential for maintaining the architecture of ERGIC and Golgi by controlling COP I recruitment. ..
  5. Sun Y, Cheng L, Gu Y, Xin A, Wu B, Zhou S, et al. A Human Lectin Microarray for Sperm Surface Glycosylation Analysis. Mol Cell Proteomics. 2016;15:2839-51 pubmed publisher
    ..and strong bindings were observed for several lectins, including galectin-1, 7, 8, GalNAc-T6, and ERGIC-53 (LMAN1). These bindings were validated by flow cytometry and fluorescence immunostaining...
  6. Otahal A, Fuchs R, Al Allaf F, Blaas D. Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. J Virol. 2015;89:11723-6 pubmed publisher
    ..Intracellular VSVG granules colocalized with LDLR, ER-Golgi intermediate compartment protein 53 (ERGIC53), LAMP2, and vimentin but not with GM130 or calnexin, suggesting that VSVG interacts with LDLR within the ERGIC, ..
  7. Russo R, Esposito M, Iolascon A. Inherited hematological disorders due to defects in coat protein (COP)II complex. Am J Hematol. 2013;88:135-40 pubmed publisher
  8. Peng M, Li S, He Q, Zhao J, Li L, Ma H. Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity. BMC Genomics. 2018;19:29 pubmed publisher
    ..that fatty acid degradation (upregulated ACAA2, CPT1A, and ACOX1), protein folding (upregulated PDIs, CALR3, LMAN1, and UBQLN1) and gluconeogenesis (upregulated ACSS1, AKR1A1, ALDH3A2, ALDH7A1, and FBP2) were enhanced from ..
  9. Teillet F, Dublet B, Andrieu J, Gaboriaud C, Arlaud G, Thielens N. The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J Immunol. 2005;174:2870-7 pubmed
    ..These results provide the first precise analysis of the major human MBL oligomers. The oligomerization state of MBL has a direct effect on its carbohydrate-binding properties, but no influence on the interaction with the MASPs. ..
  10. Mataki H, Seki N, Mizuno K, Nohata N, Kamikawaji K, Kumamoto T, et al. Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. Oncotarget. 2016;7:72084-72098 pubmed publisher
    ..We identified seven putative target genes (MTDH, EPN3, TPD52, CYP27B1, LMAN1, STAT1 and TXNDC12) that were coordinately regulated by miR-145-5p and miR-145-3p in lung SCC...
  11. Zhang B, Cunningham M, Nichols W, Bernat J, Seligsohn U, Pipe S, et al. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet. 2003;34:220-5 pubmed
    Mutations in LMAN1 (also called ERGIC-53) result in combined deficiency of factor V and factor VIII (F5F8D), an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins...
  12. Harris R, Yang A, Stein R, Lucy K, Brusten L, Herath A, et al. Cluster analysis of an extensive human breast cancer cell line protein expression map database. Proteomics. 2002;2:212-23 pubmed
    ..Mass spectrometry was used to identify the proteins. The possible role of these proteins in cancer is discussed. ..
  13. Saifuddin M, Hart M, Gewurz H, Zhang Y, Spear G. Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. J Gen Virol. 2000;81:949-55 pubmed
    ..This study shows that PI of HIV bind to MBL and suggests that MBL can selectively interact with HIV in vivo via carbohydrate structures on gp120/gp41. ..
  14. Gabolde M, Hubert D, Guilloud Bataille M, Lenaerts C, Feingold J, Besmond C. The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis. J Med Genet. 2001;38:310-1 pubmed
  15. Zheng C, Liu H, Zhou J, Zhang B. EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII. Blood. 2010;115:1081-7 pubmed publisher
    Combined deficiency of factor V and factor VIII (F5F8D) is a bleeding disorder caused by mutations in either LMAN1 or MCFD2...
  16. Segal A, Zivelin A, Rosenberg N, Ginsburg D, Shpilberg O, Seligsohn U. A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia. Blood Coagul Fibrinolysis. 2004;15:99-102 pubmed
    ..of factor V and factor VIII is a rare autosomal recessive bleeding disorder that is caused by mutations in the LMAN1 or MCFD2 genes...
  17. Rector A, Lemey P, Laffut W, Keyaerts E, Struyf F, Wollants E, et al. Mannan-binding lectin (MBL) gene polymorphisms in ulcerative colitis and Crohn's disease. Genes Immun. 2001;2:323-8 pubmed
    ..This could be explained by the differential T-helper response in both diseases. ..
  18. Roeckel N, Woerner S, Kloor M, Yuan Y, Patsos G, Gromes R, et al. High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability. Cancer Res. 2009;69:292-9 pubmed publisher
    ..Among 28 candidate genes, LMAN1/ERGIC53, a mannose-specific lectin mediating endoplasmatic reticulum (ER)-to-Golgi transit of glycosylated proteins, ..
  19. Selander B, Martensson U, Weintraub A, Holmström E, Matsushita M, Thiel S, et al. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest. 2006;116:1425-34 pubmed
    ..MBL-dependent C2 bypass activation could be particularly important in various inherited and acquired complement deficiency states. ..
  20. Fiedler K, Simons K. A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins. Cell. 1994;77:625-6 pubmed
  21. Nyfeler B, Zhang B, Ginsburg D, Kaufman R, Hauri H. Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. Traffic. 2006;7:1473-81 pubmed
    ..The results indicate that ERGIC-53 can bind cargo glycoproteins in an MCFD2-independent fashion and suggest that MCFD2 is a recruitment factor for blood coagulation factors V and VIII. ..
  22. Lievens P, De Servi B, Garofalo S, Lunstrum G, Horton W, Liboi E. Transient dimerization and interaction with ERGIC-53 occur in the fibroblast growth factor receptor 3 early secretory pathway. Int J Biochem Cell Biol. 2008;40:2649-59 pubmed publisher
    ..Furthermore, the TDII/ERGIC-53 complex formation may function as a checkpoint for FGFR3 sorting downstream the endoplasmic reticulum. These findings have implications for understanding the pathogenesis of FGFR3-related disorders. ..
  23. Abe F, Van Prooyen N, Ladasky J, Edidin M. Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum. J Immunol. 2009;182:4776-83 pubmed publisher
    ..Thus, in HeLa cells, Bap31 is involved in the exit of peptide-loaded MHC class I from the ER, and its function is regulated by its interaction with its homologue, Bap29. ..
  24. Torun D, Yilmaz E, Atay A, Kurekci E, Akar N. Two new mutations at ERGIC-53 gene in a Turkish family. Clin Appl Thromb Hemost. 2011;17:248-50 pubmed publisher
    ..Combined factor V and factor VIII deficiency is caused by mutations in ERGIC-53 (LMAN1) gene...
  25. Tanimoto K, Suzuki K, Jokitalo E, Sakai N, Sakaguchi T, Tamura D, et al. Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip domain family proteins. Cell Struct Funct. 2011;36:171-85 pubmed
    ..The knockdown of YIPF3 or YIPF4 in HeLa cells induced fragmentation of the Golgi apparatus, suggesting their involvement in the maintenance of the Golgi structure. ..
  26. Duellman T, Burnett J, Shin A, Yang J. LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Biochem Biophys Res Commun. 2015;464:685-91 pubmed publisher
    ..Through a complementation assay, we determined that LMAN1, a well-studied lectin-carrier protein, interacts with a secretion-competent N-glycosylated MMP-9 in the ER while ..
  27. Klaus J, Eisenhauer P, Russo J, Mason A, Do D, King B, et al. The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. Cell Host Microbe. 2013;14:522-34 pubmed publisher
    ..Thus, we have identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families. ..
  28. Haurum J, Thiel S, Jones I, Fischer P, Laursen S, Jensenius J. Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins. AIDS. 1993;7:1307-13 pubmed
    ..Activation of the classical complement pathway by retrovirus envelope proteins can be initiated by the binding of MBP to carbohydrate side chains of envelope glycoproteins. ..
  29. Garcia Laorden M, Rua Figueroa I, Perez Aciego P, Rodríguez Pérez J, Citores M, Alamo F, et al. Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain. J Rheumatol. 2003;30:740-6 pubmed
    ..021, p = 0.038, respectively). MBL deficiency is not a risk factor for SLE in women from the Canary Islands, but it is associated with lower prevalence of autoantibodies and with later age at disease onset and at SLE diagnosis. ..
  30. Hart M, Saifuddin M, Spear G. Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. J Gen Virol. 2003;84:353-60 pubmed
    ..This study shows that specific alterations of the N-linked carbohydrates on HIV gp120/gp41 can enhance MBL-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL. ..
  31. Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A. Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization. Mamm Genome. 1996;7:791-2 pubmed
  32. Cheong J, Cho S, Lim S, Shin D, Yoon S, Lee J, et al. Lack of association between hepatitis B virus infection and polymorphism of mannose-binding lectin gene in Korean population. J Korean Med Sci. 2005;20:65-9 pubmed
    ..166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection. ..
  33. Mohanty D, Ghosh K, Shetty S, Spreafico M, Garagiola I, Peyvandi F. Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII. Am J Hematol. 2005;79:262-6 pubmed
    Combined deficiency of factors V (FV) and factor VIII (FVIII) (F5F8D) is an autosomal recessive bleeding disorder caused by simultaneous moderate-to-mild decrease of both clotting proteins...
  34. Ben Tekaya H, Miura K, Pepperkok R, Hauri H. Live imaging of bidirectional traffic from the ERGIC. J Cell Sci. 2005;118:357-67 pubmed
    ..These results suggest that the ERGIC is stationary and not simply a collection of mobile carriers that mediate protein traffic from endoplasmic reticulum to Golgi. ..
  35. Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan M, et al. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood. 2008;111:5592-600 pubmed publisher
    Combined deficiency of factor V and factor VIII (F5F8D) is caused by mutations in one of 2 genes, either LMAN1 or MCFD2...
  36. Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. Semin Thromb Hemost. 2013;39:613-20 pubmed publisher
    ..Genetic studies identified LMAN1 and MCFD2 as causative genes for this disorder, revealing a previously unknown intracellular transport pathway ..
  37. Nyfeler B, Nufer O, Matsui T, Mori K, Hauri H. The cargo receptor ERGIC-53 is a target of the unfolded protein response. Biochem Biophys Res Commun. 2003;304:599-604 pubmed
    ..Thapsigargin-induced upregulation of ERGIC-53 could be fully accounted for by the ATF6 pathway of UPR. The results suggest that in mammalian cells the UPR also affects traffic from and beyond the ER. ..
  38. Cunningham M, Pipe S, Zhang B, Hauri H, Ginsburg D, Kaufman R. LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. J Thromb Haemost. 2003;1:2360-7 pubmed
    ..coagulation factors (F)V and VIII is a rare autosomal recessive bleeding disorder caused by null expression of LMAN1 (previously termed ERGIC-53) in a majority of affected individuals...
  39. Jüliger S, Kremsner P, Alpers M, Reeder J, Kun J. Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea. Mutat Res. 2002;505:87-91 pubmed
    ..One site was in the untranslated region of the MBL gene at position +1 (G-->A, termed R/S), and the second was located upstream of the gene at position -4 (G-->A, termed T/U). ..
  40. Best L, Davidson M, North K, Maccluer J, Zhang Y, Lee E, et al. Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart Study. Circulation. 2004;109:471-5 pubmed
    ..A high prevalence of variant MBL alleles and CAD in this population suggests that potentially important public health benefits may accrue from future interventions based on these genotypes. ..
  41. Palaniyar N, Nadesalingam J, Clark H, Shih M, Dodds A, Reid K. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem. 2004;279:32728-36 pubmed
    ..Collectins may therefore play an important role in decreasing the inflammation caused by DNA in lungs and other tissues. ..
  42. Fraldi A, Zito E, Annunziata F, Lombardi A, Cozzolino M, Monti M, et al. Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum Mol Genet. 2008;17:2610-21 pubmed publisher
    ..When over-expressed, each of three interactors favors intracellular accumulation. Our results reveal a multistep control of SUMF1 trafficking, with sequential interactions dynamically determining ER localization, activity and secretion. ..
  43. Nichols W, Seligsohn U, Zivelin A, Terry V, Hertel C, Wheatley M, et al. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell. 1998;93:61-70 pubmed
    ..These findings suggest that ERGIC-53 may function as a molecular chaperone for the transport from ER to Golgi of a specific subset of secreted proteins, including coagulation factors V and VIII. ..
  44. Mattioli L, Anelli T, Fagioli C, Tacchetti C, Sitia R, Valetti C. ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies. J Cell Sci. 2006;119:2532-41 pubmed
    ..Our findings identify a novel ERGIC-53 substrate, and indicate that interactions with light chains or ERGIC-53 seed muDeltaCH1 condensation in different stations of the early secretory pathway. ..
  45. Zhang B, Kaufman R, Ginsburg D. LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway. J Biol Chem. 2005;280:25881-6 pubmed
    Mutations in LMAN1 (ERGIC-53) and MCFD2 are the causes of a human genetic disorder, combined deficiency of coagulation factor V and factor VIII. LMAN1 is a type 1 transmembrane protein with homology to mannose-binding lectins...
  46. Arar C, Carpentier V, Le Caer J, Monsigny M, Legrand A, Roche A. ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells. J Biol Chem. 1995;270:3551-3 pubmed
    A mannose-specific membrane lectin (MR60) isolated from human myelomonocytic HL60 cells by affinity chromatography is expressed in intracellular organelles of immature monocytes (Pimpaneau, V., Midoux, P., Monsigny, M., and Roche, A. C...
  47. Nishio M, Kamiya Y, Mizushima T, Wakatsuki S, Sasakawa H, Yamamoto K, et al. Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency. Proc Natl Acad Sci U S A. 2010;107:4034-9 pubmed publisher
    Combined deficiency of coagulation factors V and VIII (F5F8D), an autosomal recessive disorder characterized by coordinate reduction in the plasma levels of factor V (FV) and factor VIII (FVIII), is genetically linked to mutations in the ..
  48. Nichols W, Terry V, Wheatley M, Yang A, Zivelin A, Ciavarella N, et al. ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. Blood. 1999;93:2261-6 pubmed
    ..Taken together, these results suggest that a significant subset of combined factors V and VIII deficiency is due to mutation in one or more additional genes. ..
  49. Pasqualini E, Caillol N, Panicot L, Mas E, Lloubes R, Lombardo D. Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase. J Biol Chem. 1998;273:28208-18 pubmed
    ..Consequently, the retention of the oncofetal variant of BSDL observed in human pancreatic tumoral cells might not result from inherent properties of the protein. ..
  50. Kronborg G, Weis N, Madsen H, Pedersen S, Wejse C, Nielsen H, et al. Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis. 2002;185:1517-20 pubmed
    ..Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities. ..
  51. Negi V, Devaraju P, Misra D, Jain V, Usdadiya J, Antony P, et al. Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus. Clin Rheumatol. 2017;36:837-843 pubmed publisher
    ..However, the association of codon 54 (rs1800450) with medium vessel vasculitis suggests that it may be a genetic modifier of clinical phenotype in SLE. ..
  52. Tang Y, Ma D, Ming S, Zhang L, Zhou J, Shan G, et al. Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production by human monocytes. Microbiol Immunol. 2015;59:231-7 pubmed publisher
    ..These observations indicate that MBL can down-regulate CpG DNA-induced TLR9 activation, emphasizing the importance of understanding the interaction of MBL with TLR agonist in host immune defense. ..
  53. Neerman Arbez M, Antonarakis S, Blouin J, Zeinali S, Akhtari M, Afshar Y, et al. The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103. Am J Hum Genet. 1997;61:143-50 pubmed
    Combined factor V-factor VIII deficiency (F5F8D) is a rare, autosomal recessive coagulation disorder in which the levels of both coagulation factor V and coagulation factor VIII are diminished...
  54. Hart M, Saifuddin M, Uemura K, Bremer E, Hooker B, Kawasaki T, et al. High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1. AIDS Res Hum Retroviruses. 2002;18:1311-7 pubmed
    ..These studies provide evidence that MBL binds to HIV via high mannose carbohydrates on gp120 and shows that the interaction of MBL with virus is regulated by sialylation. ..
  55. Senaldi G, Davies E, Mahalingam M, Lu J, Pozniak A, Peakman M, et al. Circulating levels of mannose binding protein in human immunodeficiency virus infection. J Infect. 1995;31:145-8 pubmed
    ..The possibility that MBP plays a defensive role in HIV infection cannot be excluded, but, it it is, it does not appear to act by recruiting complement for vital elimination. ..
  56. Wakana Y, Koyama S, Nakajima K, Hatsuzawa K, Nagahama M, Tani K, et al. Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi. Biochem Biophys Res Commun. 2005;334:1198-205 pubmed
    ..These results suggest that RTN3 plays a role in membrane trafficking in the early secretory pathway. ..
  57. Garred P, J Strøm J, Quist L, Taaning E, Madsen H. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis. 2003;188:1394-403 pubmed
    ..These data show that MBL insufficiency plays an important role in the susceptibility of critically ill patients to the development and progression of sepsis and confers a substantial risk of fatal outcome. ..
  58. Iinuma T, Aoki T, Arasaki K, Hirose H, Yamamoto A, Samata R, et al. Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. J Cell Sci. 2009;122:1680-90 pubmed publisher
    ..These results suggest that syntaxin 18 has an important role in ER subdomain organization by mediating the fusion of retrograde membrane carriers with the ER membrane...
  59. Matthijsen R, de Winther M, Kuipers D, van der Made I, Weber C, Herias M, et al. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2009;119:2188-95 pubmed publisher
    ..These results are the first to show that MBL is abundantly present and locally produced during early atherogenesis. Local MBL expression, by myeloid cells, is shown to critically control development of atherosclerotic lesions. ..
  60. Madan T, Kaur S, Saxena S, Singh M, Kishore U, Thiel S, et al. Role of collectins in innate immunity against aspergillosis. Med Mycol. 2005;43 Suppl 1:S155-63 pubmed
    ..Our results show that collectins play an important role in Aspergillus mediated allergies and infections. ..
  61. Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C, et al. Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 2007;26:4177-88 pubmed
    ..Our findings suggest that ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control. ..
  62. Renna M, Caporaso M, Bonatti S, Kaufman R, Remondelli P. Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress. J Biol Chem. 2007;282:22499-512 pubmed
    ..A molecular model for the transcriptional regulation of the ERGIC-53 gene is proposed. ..
  63. Kamiya Y, Kamiya D, Yamamoto K, Nyfeler B, Hauri H, Kato K. Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36. J Biol Chem. 2008;283:1857-61 pubmed
    ..Moreover, structure-based mutagenesis revealed that the sugar-binding properties of these L-type lectins can be switched by single amino acid substitutions. ..
  64. Schindler R, Itin C, Zerial M, Lottspeich F, Hauri H. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. Eur J Cell Biol. 1993;61:1-9 pubmed
    ..The presence of an ER retention motif in a protein of the ER-Golgi intermediate compartment has important implications for the retention mechanism mediated by this signal. ..
  65. Neve E, Lahtinen U, Pettersson R. Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds. J Mol Biol. 2005;354:556-68 pubmed
    ..Based on these results, we present a model for the formation of the two hexameric forms. ..
  66. Morais V, Brito C, Pijak D, Crystal A, Fortna R, Li T, et al. N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53. Biochim Biophys Acta. 2006;1762:802-10 pubmed
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    ..01). Wild-type allele A homozygosity is protective against, while carriage of the variant allele B is a risk factor for, Fallopian tube occlusion in women who are seropositive or seronegative for C. trachomatis. ..
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    ..This study shows that MBL prevents DC-SIGN-mediated trans infection of T cells in vitro and suggests that in infected persons, MBL may inhibit DC-SIGN-mediated uptake and spread of HIV. ..
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    ..This review summarizes, principally from a structural point of view, the current state of knowledge about these high-mannose binding proteins and their mode of sugar binding. ..
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    ..These results support the view that ERGIC-53 alone, or in association with MCFD2, plays important functions during cellular response to stress conditions. ..
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    ..Mutations in LMAN1 and MCFD2 can cause combined deficiency of factors V and VIII (F5F8D). We present the crystal structure of the LMAN1/MCFD2 complex and relate it to patient mutations...
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    ..These results establish that TMEM115 is an integral membrane protein of the Golgi stack regulating Golgi-to-ER retrograde transport and is likely to be part of the machinery of the COG complex. ..