LLGL2

Summary

Gene Symbol: LLGL2
Description: LLGL2, scribble cell polarity complex component
Alias: HGL, Hugl-2, LGL2, lethal(2) giant larvae protein homolog 2, human giant larvae homolog, lethal giant larvae homolog 2, scribble cell polarity complex component
Species: human
Products:     LLGL2

Top Publications

  1. Zimmermann T, Kashyap A, Hartmann U, Otto G, Galle P, Strand S, et al. Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene. Biochem Biophys Res Commun. 2008;366:1067-73 pubmed
    The human lgl gene, Hugl-2 (llgl2, Lgl2), codes for a cytoskeletal protein involved in regulating cell polarity. Here, we report the identification and functional characterization of the promoter region ( approximately 1...
  2. Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 2008;68:537-44 pubmed publisher
    ..Thereby, ZEB1 suppresses the expression of cell polarity factors, in particular of Lgl2, which we found reduced in colorectal and breast cancers...
  3. Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, et al. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol. 2003;13:734-43 pubmed
    ..These results indicate that PAR-6/aPKC selectively interacts with either mLgl or PAR-3 under the control of aPKC activity to regulate epithelial cell polarity. ..
  4. Kujawski S, Sonawane M, Knust E. penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina. Biol Open. 2019;8: pubmed publisher
    ..Here, we analyzed the role of Lgl2, a basolateral polarity factor, in the zebrafish retina...
  5. Sonawane M, Carpio Y, Geisler R, Schwarz H, Maischein H, Nuesslein Volhard C. Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis. Development. 2005;132:3255-65 pubmed
    ..using a forward genetic approach in zebrafish as we show that the function of penner (pen)/lethal giant larvae 2 (lgl2) is necessary for hemidesmosome formation and maintenance of the tissue integrity in the developing basal epidermis...
  6. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, et al. LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature. 2019;: pubmed publisher
    Drosophila Lgl and its mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of apical-basal polarity in epithelial cells1,2...
  7. Tay H, Schulze S, Compagnon J, Foley F, Heisenberg C, Yost H, et al. Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle. Development. 2013;140:1550-9 pubmed publisher
    ..In the zebrafish embryo, lethal giant larvae 2 (lgl2) is expressed prominently in ciliated organs...
  8. Zhang X, Chang H, Taylor E, Liu R, Leung P. BMP6 Downregulates GDNF Expression Through SMAD1/5 and ERK1/2 Signaling Pathways in Human Granulosa-Lutein Cells. Endocrinology. 2018;159:2926-2938 pubmed publisher
    ..We used an established immortalized human granulosa cell line (SVOG cells) and primary human granulosa-lutein (hGL) cells as in vitro cell models...
  9. Christensen I, Mogensen E, Damkier H, Praetorius J. Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain. Am J Physiol Cell Physiol. 2018;314:C519-C533 pubmed publisher
    ..Lethal(2) giant larvae homolog 2 (Lgl2) labeling was preferentially observed in the luminal membrane domain...

More Information

Publications46

  1. Alsaleem M, Toss M, Joseph C, Aleskandarany M, Kurozumi S, Alshankyty I, et al. The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts. Mod Pathol. 2019;: pubmed publisher
    ..CDH1 mRNA expression showed elevated expression of E-cadherin transcription suppressors TWIST2, ZEB2, NFKB1, LLGL2, CTNNB1 (p < 0.01)...
  2. Reischauer S, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet. 2009;5:e1000720 pubmed publisher
    ..Here, we show that the pen/lgl2 mutant phenotype shares two key cellular and molecular features of mammalian malignancy: cell autonomous epidermal ..
  3. Zhang X, Chang H, Zhu H, Liu R, Leung P. BMP6 increases TGF-β1 production by up-regulating furin expression in human granulosa-lutein cells. Cell Signal. 2019;55:109-118 pubmed publisher
    ..Primary and immortalized (SVOG) human granulosa-lutein (hGL) cells were used as study models...
  4. Bai L, Chang H, Zhu Y, Leung P. Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells. Cell Signal. 2019;53:201-211 pubmed publisher
    ..to investigate the effect of BMP2 on the regulation of LOX expression and activity in human granulosa-lutein cells (hGL) and the underlying mechanisms...
  5. Xu Y, Wu W, Fan Y, Jiang S, Jia X, Su W. MiR-142-3p Inhibits TGF-β3-Induced Blood-Testis Barrier Impairment by Targeting Lethal Giant Larvae Homolog 2. Cell Physiol Biochem. 2018;46:253-268 pubmed publisher
    ..A luciferase reporter assay was used to testify the potential target of miR-142-3p, lethal giant larvae 2 (Lgl2)...
  6. Ager A, Zarowsky C. Balancing the personal, local, institutional, and global: multiple case study and multidimensional scaling analysis of African experiences in addressing complexity and political economy in health research capacity strengthening. Health Res Policy Syst. 2015;13:5 pubmed publisher
    ..The Health Research Capacity Strengthening (HRCS) Global Learning (HGL) program of work documented experiences of HRCS across sub-Saharan Africa...
  7. Matern S, Peskan Berghoefer T, Gromes R, Kiesel R, Rausch T. Imposed glutathione-mediated redox switch modulates the tobacco wound-induced protein kinase and salicylic acid-induced protein kinase activation state and impacts on defence against Pseudomonas syringae. J Exp Bot. 2015;66:1935-50 pubmed publisher
    ..Wild-type (WT) Nicotiana tabacum L. and transgenic high-glutathione lines (HGL) were transformed with the cytosol-targeted sensor GRX1-roGFP2 to monitor the cytosolic redox state...
  8. Yamashita K, Ide M, Furukawa K, Suzuki A, Hirano H, Ohno S. Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex. Mol Biol Cell. 2015;26:2426-38 pubmed publisher
    ..Here we show that depletion of Lgl1 and Lgl2 in MDCK epithelial cells results in overproliferation and overproduction of Lgl2 causes G1 arrest...
  9. Borah R, Mamidi N, Panda S, Gorai S, Pathak S, Manna D. Elucidating the interaction of γ-hydroxymethyl-γ-butyrolactone substituents with model membranes and protein kinase C-C1 domains. Mol Biosyst. 2015;11:1389-99 pubmed publisher
    ..In this report γ-hydroxymethyl-γ-butyrolactone (HGL) substituents were investigated in an effort to develop small molecule-based PKC regulators with higher specificity ..
  10. Mirza N, Klein C, Palmer M, McCarter R, He J, Ebbeling C, et al. Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth. Int J Pediatr Obes. 2011;6:e523-31 pubmed publisher
    ..To examine the effects of LGL and high-GL (HGL) meals on appetitive responses and ad libitum energy intake of obese Hispanic youth...
  11. Yadav R, Verma K, Chandra M, Mukherjee M, Datta S. Biophysical studies on calcium and carbohydrate binding to carbohydrate recognition domain of Gal/GalNAc lectin from Entamoeba histolytica: insights into host cell adhesion. J Biochem. 2016;160:177-86 pubmed publisher
    ..In this study, carbohydrate recognition domain of Hgl (EhCRD) was purified and biophysical studies were conducted to understand the thermodynamic basis of its binding to ..
  12. Li C, Wang S, Xing Z, Lin A, Liang K, Song J, et al. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol. 2017;19:106-119 pubmed publisher
    ..p-HER3 Tyr1307 recruits the LLGL2-MAYA-NSUN6 RNA-protein complex to methylate Hippo/MST1 at Lys59...
  13. Hu Q, Xie F, Hong X, Liu K. [Establishment of esophageal squamous carcinoma cell lines stably over-expressing LLGL2]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:342-346 pubmed
    Objective To prepare a lentiviral vector expressing LLGL2 and establish KYSE450 and TE-1 cell lines for the stable expression of LLGL2...
  14. Westcot S, Hatzold J, Urban M, Richetti S, Skuster K, Harm R, et al. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS ONE. 2015;10:e0130688 pubmed publisher
    ..Moreover, knockdown of the epithelial polarity regulator and tumor suppressor lgl2 ameliorated the nrg2a mutant phenotype...
  15. Saito Y, DESAI R, Muthuswamy S. Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. Biochim Biophys Acta Rev Cancer. 2018;1869:103-116 pubmed publisher
    ..of published cancer dataset shows that many polarity genes, including PARD6B, SCRIB, PRKCI, DLG1, DLG2, DLG5 and LLGL2, are frequently amplified in multiple cancers raising the possibility that mammalian epithelia may have evolved to ..
  16. Sassene P, Fanø M, Mu H, Rades T, Aquistapace S, Schmitt B, et al. Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates. Food Funct. 2016;7:3989-3998 pubmed
    The aim of this study was to find a lipase suitable as a surrogate for Human Gastric Lipase (HGL), since the development of predictive gastrointestinal lipolysis models are hampered by the lack of a lipase with similar digestive ..
  17. Kato K, Yahata K, Gopal Dhoubhadel B, Fujii Y, Tachibana H. Novel hemagglutinating, hemolytic and cytotoxic activities of the intermediate subunit of Entamoeba histolytica lectin. Sci Rep. 2015;5:13901 pubmed publisher
    ..The lectin consists of heavy (Hgl), light (Lgl), and intermediate (Igl) subunits...
  18. Chang H, Fang L, Cheng J, Taylor E, Sun Y, Leung P. Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells. Fertil Steril. 2016;105:520-8 pubmed publisher
    ..role of growth differentiation factor 8 (GDF8) in the regulation of steroidogenesis in human granulosa-lutein (hGL) cells. Experimental study. Academic medical center. In vitro fertilization patients who provided hGL cells...
  19. Barbáchano A, Fernández Barral A, Pereira F, Segura M, Ordóñez Morán P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed publisher
    ..Moreover, SPRY2 represses LLGL2/HUGL2, PATJ1/INADL and ST14, main regulators of the polarized epithelial phenotype, and ESRP1, an epithelial-to-..
  20. Zhang Q, Bu S, Sun J, Xu M, Yao X, He K, et al. Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage. Stem Cell Res Ther. 2017;8:270 pubmed publisher
    ..further investigated whether hAECs could affect chemotherapy-induced apoptosis in primary human granulosa-lutein (hGL) cells and the tube formation of human umbilical vein endothelial cells (hUVECs) via a co-culture system in vitro...
  21. Vardakou M, Sainsbury F, Rigby N, Mulholland F, Lomonossoff G. Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system. Protein Expr Purif. 2012;81:69-74 pubmed publisher
    Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system. Expression levels of up to 0.5mg recombinant hGL per gram of infiltrated leaf tissue were obtained...
  22. Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, et al. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 2009;207:144-9 pubmed publisher
    ..Three SNPs (rs1671021 of LLGL2, rs9615362 of CELSR1, and rs753307 of RUVBL2) were significantly (P<0.05) associated with ischemic stroke...
  23. Patil D, Bennett A, Mahajan D, Bronner M. Distinguishing Barrett gastric foveolar dysplasia from reactive cardiac mucosa in gastroesophageal reflux disease. Hum Pathol. 2013;44:1146-53 pubmed publisher
    ..These were compared with inflamed cardia from 80 patients with GERD. Immunohistochemistry was performed for Lgl2, MUC2, MUC5AC, and MUC6...
  24. Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, et al. Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem. 2005;280:6761-5 pubmed
    ..Par-6 complex. We showed here that Lgl2, a mammalian homolog of l(2)gl, directly bound to LGN, a mammalian homolog of Partner of inscuteable in HEK293 ..
  25. Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, et al. Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol. 2009;22:977-84 pubmed publisher
    ..Two homologs, lgl1 and lgl2, are present in mammals and lgl2 mRNA is highly expressed in the stomach...
  26. Lisovsky M, Dresser K, Woda B, Mino Kenudson M. Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. Hum Pathol. 2010;41:902-9 pubmed publisher
    ..Loss or abnormal lethal giant larvae 2 expression is seen in pancreatic intraepithelial neoplasia-3 and adenocarcinoma and might be useful in separating them from lower-grade pancreatic intraepithelial neoplasias. ..
  27. Lisovsky M, Ogawa F, Dresser K, Woda B, Lauwers G. Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta. Virchows Arch. 2010;457:635-42 pubmed publisher
    ..In this study, we evaluated whether Lgl2 can serve as a marker of gastric foveolar-type dysplasia...
  28. Russ A, Louderbough J, Zarnescu D, Schroeder J. Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. PLoS ONE. 2012;7:e47734 pubmed publisher
    ..Overall, these data demonstrate an essential role for both Hugl1 and Hugl2 in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. ..
  29. Lim D, Lee J. Relationship Between Dual Time Point FDG PET/CT and Clinical Prognostic Indexes in Patients with High Grade Lymphoma: a Pilot Study. Nucl Med Mol Imaging. 2017;51:323-330 pubmed publisher
    ..We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL).
  30. Bragg C, Desbrow B, Hall S, Irwin C. Effect of meal glycemic load and caffeine consumption on prolonged monotonous driving performance. Physiol Behav. 2017;181:110-116 pubmed publisher
    ..consuming: (1) a low glycemic load meal+placebo capsules (LGL), (2) a high glycemic load meal+placebo capsules (HGL) and (3) a high glycemic load meal+caffeine capsules (3mgkg-1 body weight) (CAF)...
  31. Passaretti D, Candela V, Sessa P, Gumina S. Epidemiology of proximal humeral fractures: a detailed survey of 711 patients in a metropolitan area. J Shoulder Elbow Surg. 2017;26:2117-2124 pubmed publisher
    ..A significant correlation between trauma mechanisms from 1 to 5 and fracture patterns H-G-L-S, HL-G-S, HGL-S, and HLS-G was observed...
  32. Sams L, Amara S, Chakroun A, Coudre S, Paume J, Giallo J, et al. Constitutive expression of human gastric lipase in Pichia pastoris and site-directed mutagenesis of key lid-stabilizing residues. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1025-1034 pubmed publisher
    The cDNA encoding human gastric lipase (HGL) was integrated into the genome of Pichia pastoris using the pGAPZ? A transfer vector. The HGL signal peptide was replaced by the yeast ?-factor to achieve an efficient secretion...
  33. Imamura N, Horikoshi Y, Matsuzaki T, Toriumi K, Kitatani K, Ogura G, et al. Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression. Tokai J Exp Clin Med. 2013;38:146-58 pubmed
    ..On double-immunohistochemical analysis, aPKC ?/? and Lgl2, a protein that interacts with aPKC ?/?, were co-localized within LACs...
  34. Bai L, Chang H, Cheng J, Chu G, Leung P, Yang G. ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells. Endocrinology. 2017;158:3501-3511 pubmed publisher
    ..expression (the major component of cumulus expansion) and the underlying mechanisms in human granulosa-lutein (hGL) cells. Both primary and immortalized hGL cells were used as research models...
  35. Kashyap A, Zimmerman T, Ergul N, Bosserhoff A, Hartman U, Alla V, et al. The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis. Oncogene. 2013;32:1396-407 pubmed publisher
    ..In our studies we identified the human lethal giant larvae homologue 2, Hugl-2, (Llgl2/Lgl2) polarity gene as downregulated by Snail...
  36. Bai L, Chang H, Cheng J, Chu G, Leung P, Yang G. Lithium chloride inhibits StAR and progesterone production through GSK-3β and ERK1/2 signaling pathways in human granulosa-lutein cells. Mol Cell Endocrinol. 2018;461:89-99 pubmed publisher
    ..In this study, both primary and immortalized human granulosa-lutein (hGL) cells were used to investigate the effects of LiCl on progesterone production and its related enzyme expression as ..
  37. Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, et al. Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. Cell Res. 2014;24:451-63 pubmed publisher
    ..The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex ..