LITAF

Summary

Gene Symbol: LITAF
Description: lipopolysaccharide induced TNF factor
Alias: PIG7, SIMPLE, TP53I7, lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, lipopolysaccharide-induced TNF-alpha factor, p53-induced gene 7 protein, small integral membrane protein of lysosome/late endosome, tumor protein p53 inducible protein 7
Species: human
Products:     LITAF

Top Publications

  1. Polyak K, Xia Y, Zweier J, Kinzler K, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300-5 pubmed
  2. Tang X, Fenton M, Amar S. Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A. 2003;100:4096-101 pubmed
    ..Previously, a transcription factor, termed lipopolysaccharide-induced TNF-alpha factor (LITAF), was found to regulate TNF-alpha gene expression...
  3. Lee S, Olzmann J, Chin L, Li L. Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci. 2011;124:3319-31 pubmed publisher
    Mutations in SIMPLE cause an autosomal dominant, demyelinating form of peripheral neuropathy termed Charcot-Marie-Tooth disease type 1C (CMT1C), but the pathogenic mechanisms of these mutations remain unknown...
  4. Saifi G, Szigeti K, Wiszniewski W, Shy M, Krajewski K, Hausmanowa Petrusewicz I, et al. SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat. 2005;25:372-83 pubmed
    ..Recently, SIMPLE/LITAF was shown to be responsible for an autosomal dominant demyelinating form of CMT linked to 16p (CMT1C)...
  5. Beauvais K, Furby A, Latour P. Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE. Neuromuscul Disord. 2006;16:14-8 pubmed
    ..of Charcot-Marie-Tooth disease with dominant inheritance, five genes have been incriminated: PMP22, MPZ, LITAF/SIMPLE, EGR2 (CMT1A to D), and GJB1 (CMTX)...
  6. Latour P, Gonnaud P, Ollagnon E, Chan V, Perelman S, Stojkovic T, et al. SIMPLE mutation analysis in dominant demyelinating Charcot-Marie-Tooth disease: three novel mutations. J Peripher Nerv Syst. 2006;11:148-55 pubmed
    ..type 1C (CMT1C) is caused by mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE)...
  7. Lacerda A, Hartjes E, Brunetti C. LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS ONE. 2014;9:e103454 pubmed publisher
    ..Mutations in LITAF have been shown to be causative for CMT type 1C disease...
  8. Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999;96:4518-23 pubmed
    ..that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF). Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts...
  9. Jolliffe C, Harvey K, Haines B, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351 Pt 3:557-65 pubmed
    ..These results provide evidence that Nedd4 can potentially interact with multiple proteins, possibly simultaneously, through its WW domains. ..

More Information

Publications117 found, 100 shown here

  1. Ludes Meyers J, Kil H, Bednarek A, Drake J, Bedford M, Aldaz C. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004;23:5049-55 pubmed
    ..The binding to one of these candidates, small membrane protein of the lysosome/late endosome (SIMPLE), was further analysed, and we observed that a specific PPSY motif in the SIMPLE amino-acid sequence was required ..
  2. Bennett C, Shirk A, Huynh H, Street V, Nelis E, Van Maldergem L, et al. SIMPLE mutation in demyelinating neuropathy and distribution in sciatic nerve. Ann Neurol. 2004;55:713-20 pubmed
    ..neuropathy caused by missense mutations in the small integral membrane protein of lysosome/late endosome (SIMPLE) gene...
  3. Street V, Bennett C, Goldy J, Shirk A, Kleopa K, Tempel B, et al. Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. Neurology. 2003;60:22-6 pubmed
    ..LITAF, which is also referred to as SIMPLE, is a widely expressed gene encoding a 161-amino acid protein that may play a role in protein degradation pathways...
  4. Meggouh F, de Visser M, Arts W, De Coo R, van Schaik I, Baas F. Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease. Ann Neurol. 2005;57:589-91 pubmed
    ..22 (PMP22) duplication and a mutation in the lipopolysaccharide-induced-tumour-necrosis-factor-alpha-factor (LITAF) gene, whereas each parent only had one mutated CMT gene...
  5. Tang X, Marciano D, Leeman S, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005;102:5132-7 pubmed
    ..Previously, we identified a transcription factor, LPS-induced TNF-alpha factor (LITAF), that regulates TNF-alpha transcription...
  6. Shirk A, Anderson S, Hashemi S, Chance P, Bennett C. SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J Neurosci Res. 2005;82:43-50 pubmed
    Mutation of the SIMPLE gene (small integral membrane protein of the lysosome/late endosome) is the molecular basis of Charcot-Marie-Tooth disease type 1C (CMT1C), a demyelinating peripheral neuropathy...
  7. Stucchi A, Reed K, O Brien M, Cerda S, Andrews C, Gower A, et al. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 2006;12:581-7 pubmed
    ..Recently, a new transcription factor termed LITAF (lipopolysaccharide-induced TNF-alpha factor) was shown to mediate TNF-alpha expression in human macrophages by ..
  8. Eaton H, Desrochers G, Drory S, Metcalf J, Angers A, Brunetti C. SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments. PLoS ONE. 2011;6:e16873 pubmed publisher
    ..The C-terminus of LITAF contains a highly conserved domain termed the SIMPLE-like domain (SLD), while the N-terminus contains two PPXY motifs that mediate protein-protein interactions with WW-..
  9. Moriwaki Y, Begum N, Kobayashi M, Matsumoto M, Toyoshima K, Seya T. Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. J Biol Chem. 2001;276:23065-76 pubmed
    ..this novel protein as an unglycosylated small integral membrane protein of the lysosome/late endosome (SIMPLE) whose expression is elicited in monocytes by live and heat-killed BCG, BCG cell wall complex, lipopolysaccharide, ..
  10. Lee S, Chin L, Li L. Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol. 2012;199:799-816 pubmed publisher
    Mutations in small integral membrane protein of lysosome/late endosome (SIMPLE) cause autosomal dominant, Charcot-Marie-Tooth disease (CMT) type 1C...
  11. Zhu H, Guariglia S, Yu R, Li W, Brancho D, Peinado H, et al. Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Mol Biol Cell. 2013;24:1619-37, S1-3 pubmed publisher
    ..Mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE) account for the rare autosomal-dominant demyelination in CMT1C patients...
  12. Pletzer D, Mansour S, Wuerth K, Rahanjam N, Hancock R. New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions. MBio. 2017;8: pubmed publisher
    ..Here, we describe a simple murine cutaneous abscess model that enables chronic or progressive infections, depending on the subcutaneously ..
  13. Balic A, Bukvić Mokos Z, Marinovic B, Ledić Drvar D. Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete?. Acta Dermatovenerol Croat. 2018;26:68-70 pubmed
    ..Physicians commonly misdiagnose it as tinea pedis or plantar warts. Treatment is quite simple and straightforward, with an excellent expected outcome if treated properly...
  14. Farrell G, Haczeyni F, Chitturi S. Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. Adv Exp Med Biol. 2018;1061:19-44 pubmed publisher
    ..The origins of hepatocellular injury and lobular inflammation which distinguish NASH from simple steatosis have intrigued investigators, but it is now widely accepted that NASH results from liver lipotoxicity...
  15. Rivera D, Verde A, Obón C, Alcaraz F, Moreno C, Egea T, et al. Is there nothing new under the sun? The influence of herbals and pharmacopoeias on ethnobotanical traditions in Albacete (Spain). J Ethnopharmacol. 2017;195:96-117 pubmed publisher
    ..In Albacete 1526, we determined 101 medicines (29 simple drugs and 72 compound medicines) comprising 187 ingredients (85% botanical, 7.5% mineral, and 7...
  16. Lonsdale D. Thiamine and magnesium deficiencies: keys to disease. Med Hypotheses. 2015;84:129-34 pubmed publisher
    Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being ..
  17. Chon S. Total polyphenols and bioactivity of seeds and sprouts in several legumes. Curr Pharm Des. 2013;19:6112-24 pubmed
    ..Plant phenolics include simple phenols, phenolic acids, coumarins, flavonoids, stilbenes, hydrolyzable and condensed tannins, lignans, and ..
  18. Tang X, Zan X, Zhao L, Chen H, Chen Y, Chen W, et al. Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level. Microb Cell Fact. 2016;15:35 pubmed publisher
    ..Although a simple pathway from N depletion in the medium to lipid accumulation has been elucidated at the enzymatic level, global ..
  19. Zhang X, Choi Y, Han J, Kim E, Park J, Gurunathan S, et al. Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells. Int J Nanomedicine. 2015;10:1335-57 pubmed publisher
    ..Here, we demonstrate a green and simple method for the synthesis of AgNPs using Bacillus cereus culture supernatants...
  20. Ansari A. Clinical features and pathobiology of Ebolavirus infection. J Autoimmun. 2014;55:1-9 pubmed publisher
    ..There have also been some major advances made in the identification of therapies from the very simple (major supportive type of therapy), to the identification of a number of highly effective chemotherapeutic agents, ..
  21. Amer M, Rodríguez P, Renou S, Guglielmotti M. Use of Human Fascia Lata in Rat Calvarial Bone Defects. Acta Odontol Latinoam. 2015;28:231-5 pubmed
    ..En todos los defectos óseos recubiertos con MFL simple o doble se evidenció una adecuada osteogénesis y ausencia de respuesta inflamatoria y macrófagos...
  22. Boczar M, Sawicka E, Zybert K. Meconium ileus in newborns with cystic fibrosis - results of treatment in the group of patients operated on in the years 2000-2014. Dev Period Med. 2015;19:32-40 pubmed
    ..Intra-operatively a simple form of MI was diagnosed in 8 cases, a complicated form in 2 cases...
  23. Hsiao C, Ji A, Chang C, Cheng C, Lee L, Ho J. Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury. Stem Cell Res Ther. 2015;6:113 pubmed publisher
    ..Some of transplanted cells differentiated into p450 expressing cells within 7 days. Local injection of allogenic MSCs before surgical detorsion is a simple, clinical friendly procedure to rescue torsion-induced infertility.
  24. Ventura L, Fortes N, Santiago H, Caliari M, Gomes M, Oliveira D. Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus). Peerj. 2017;5:e2967 pubmed publisher
    ..We sought to characterize the metabolic and adipose tissue changes resulting from a diet rich in fats and simple sugars in gerbils...
  25. Aizawa K, Liu C, Veeramachaneni S, Hu K, Smith D, Wang X. Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Lung Cancer. 2013;82:390-6 pubmed
    ..The development of both preneoplastic and neoplastic lesions in ferret lungs by injecting NNK alone provides a simple and highly relevant non-rodent model for studying biomarkers/molecular targets for the prevention, detection and ..
  26. Amin K, Khor W, Rosich Medina A, Beale V. Alveolar Bone Grafting: Donor Site Review of 100 Consecutive Cases in Cleft Lip and Palate. Cleft Palate Craniofac J. 2017;54:137-141 pubmed publisher
    ..The findings suggest that donor site pain may be well controlled with simple, regular analgesia. Children tolerated this procedure well and were safely discharged the day after surgery...
  27. Fan L, Luo Y, Xu J, He L, Wang J, Du X. A dosimetry study precisely outlining the heart substructure of left breast cancer patients using intensity-modulated radiation therapy. J Appl Clin Med Phys. 2014;15:4624 pubmed publisher
    ..Using CTA to delineate the substructures of the heart is simple and straightforward...
  28. Zygmanski P, Abkai C, Han Z, Shulevich Y, Menichelli D, Hesser J. Low-cost flexible thin-film detector for medical dosimetry applications. J Appl Clin Med Phys. 2014;15:4454 pubmed publisher
    ..5 cm × 5 cm area, connected to simple readout electronics...
  29. Vendrell M, Martín N, Tejedor A, Ortiz J, Muxí Ã, Taurà P. Magnesium sulphate and (123)I-MIBG in pheochromocytoma: Two useful techniques for a complicated disease. Rev Esp Anestesiol Reanim. 2016;63:48-53 pubmed publisher
    ..Prognosis of pheochromocytoma-induced heart failure can be very poor. The use of these two well-known and relatively simple 'tools' for treatment and prognosis is a helpful option to keep in mind.
  30. Nieddu M, Burrai L, Demontis M, Varoni M, Baralla E, Trignano C, et al. Simultaneous Determination of 11 Illicit Phenethylamines in Hair by LC-MS-MS: In Vivo Application. J Anal Toxicol. 2015;39:532-7 pubmed publisher
    ..The recreational and illicit use of phenethylamines is a widespread problem. A simple procedure for the simultaneous quantitative determination in hair of 11 phenethylamines that are officially ..
  31. Palmer A, Bradley D, Nisbet A. Evaluation and implementation of triple-channel radiochromic film dosimetry in brachytherapy. J Appl Clin Med Phys. 2014;15:4854 pubmed publisher
    ..can be very significant, up to 23% dose increase at 14 Gy, at ± 9 cm lateral from the scanner axis for simple single-channel dosimetry...
  32. Xhaferllari I, Wong E, Bzdusek K, Lock M, Chen J. Automated IMRT planning with regional optimization using planning scripts. J Appl Clin Med Phys. 2013;14:4052 pubmed publisher
    ..Various class solutions have been developed for simple cases (e.g., localized prostate, whole breast) to generate IMRT plans efficiently...
  33. Booi A, Menendez J, Norton H, Anderson W, Ellis A. Validation of a Screening Tool to Identify Undernutrition in Ambulatory Patients With Liver Cirrhosis. Nutr Clin Pract. 2015;30:683-9 pubmed publisher
    ..Feedback from phase I, II, and III indicate that the undernutrition screening tool is simple, is easy to use, and measures the constructs that have the strongest link with undernutrition in liver disease...
  34. Nakamura M, Sawada A, Mukumoto N, Takahashi K, Mizowaki T, Kokubo M, et al. Effect of audio instruction on tracking errors using a four-dimensional image-guided radiotherapy system. J Appl Clin Med Phys. 2013;14:255-64 pubmed publisher
    ..abdominal skin-surface displacements obtained from ten lung cancer patients under free breathing and simple audio instruction were used as an alternative to tumor motion in the superior-inferior direction...
  35. Thomas J, Tate C. Quality control in eukaryotic membrane protein overproduction. J Mol Biol. 2014;426:4139-4154 pubmed publisher
    ..This provides a simple and rapid test to suggest whether heterologously expressed mammalian membrane proteins are indeed correctly folded,..
  36. Tungu P, Malima R, Mosha F, Lyimo I, Maxwell C, Kaur H, et al. Evaluation of ICON Maxx, a long-lasting treatment kit for mosquito nets: experimental hut trials against anopheline mosquitoes in Tanzania. Malar J. 2015;14:225 pubmed publisher
    ..raises the prospect of conventional polyester nets and other materials being made long-lastingly insecticidal through simple dipping in community or home, and thus represents a major advance over conventional pyrethroid treatments.
  37. Rezende E, Bacigalupe L. Thermoregulation in endotherms: physiological principles and ecological consequences. J Comp Physiol B. 2015;185:709-27 pubmed publisher
    ..consequences of Newton's law of cooling and show that a thermoregulatory polygon provides an intuitively simple and yet useful description of thermoregulatory responses in endothermic organisms...
  38. Manage D, Pilarski L. Miniaturized technology for DNA typing: cassette PCR. Methods Mol Biol. 2015;1310:175-91 pubmed publisher
    ..We have demonstrated such a device that is self-contained, simple, disposable, and inexpensive...
  39. Watanabe M, Murakami M, Ozawa Y, Uchida M, Yamazaki K, Fujimori A, et al. The modified Altemeier procedure for a loop colostomy prolapse. Surg Today. 2015;45:1463-6 pubmed publisher
    ..The Altemeier operation is therefore indicated for rectal prolapse. This technique involves a simple operation, which includes a circumferential incision through the full thickness of the outer and inner cylinder of ..
  40. Otani Y, Yamada T, Kato S, Shikama N, Funakoshi K, Kuroda I, et al. Source strength assay of iodine-125 seeds sealed within sterile packaging. J Appl Clin Med Phys. 2013;14:4082 pubmed publisher
    ..This method is simple, time-saving, and offers greater practical application.
  41. Jursinic P. Quality assurance measurements for high-dose-rate brachytherapy without film. J Appl Clin Med Phys. 2014;15:4586 pubmed publisher
    ..To measure the absolute position of the source, a simple tool was built that uses a Plexiglas frame, a template for applicator positioning, and a diode for radiation ..
  42. Lee K, Park C, Oh J, Lee B. Non-invasive detection of intracranial hypertension using a simplified intracranial hemo- and hydro-dynamics model. Biomed Eng Online. 2015;14:51 pubmed publisher
    ..We proposed a simplified intracranial hemo- and hydro-dynamics model that consisted of two simple resistance circuits. From this proposed model, we designed an ICP estimation algorithm to trace ICP changes...
  43. Nakazawa H, Komori M, Mori Y, Hagiwara M, Shibamoto Y, Tsugawa T, et al. Effect of skull contours on dose calculations in Gamma Knife Perfexion stereotactic radiosurgery. J Appl Clin Med Phys. 2014;15:4603 pubmed publisher
    ..This paper evaluates change of treatment time induced by different skull models. A simple simulation using a uniform skull radius of 80 mm and anthropomorphic phantom was implemented in LGP to find the ..
  44. Chan M, Kwong D, Tong A, Tam E, Ng S. Evaluation of dose prediction error and optimization convergence error in four-dimensional inverse planning of robotic stereotactic lung radiotherapy. J Appl Clin Med Phys. 2013;14:4270 pubmed publisher
    Inverse optimization of robotic stereotactic lung radiotherapy is typically performed using relatively simple dose calculation algorithm on a single instance of breathing geometry...
  45. Castagnetti S, Božič B, Svetina S. Mechanical and molecular basis for the symmetrical division of the fission yeast nuclear envelope. Phys Chem Chem Phys. 2015;17:15629-36 pubmed publisher
    ..on this analysis we conclude that the fission yeast nuclear envelope exhibits the same mechanical properties as simple lipid vesicles, but interactions with other cellular components, such as chromosomes, influence the nuclear shape ..
  46. Handsfield L, Yue N, Zhou J, Chen T, Goyal S. Determination of optimal fiducial marker across image-guided radiation therapy (IGRT) modalities: visibility and artifact analysis of gold, carbon, and polymer fiducial markers. J Appl Clin Med Phys. 2012;13:3976 pubmed publisher
    ..this study was to evaluate the visibility and artifact created by gold, carbon, and polymer fiducial markers in a simple phantom across computed tomography (CT), kilovoltage (kV), and megavoltage (MV) linear accelerator imaging and MV ..
  47. Hashimoto M, Uematsu M, Ito M, Hama Y, Inomata T, Fujii M, et al. Investigation of the feasibility of a simple method for verifying the motion of a binary multileaf collimator synchronized with the rotation of the gantry for helical tomotherapy. J Appl Clin Med Phys. 2012;13:3700 pubmed publisher
    ..First, the verification was performed using a simple binary MLC pattern with a constant leaf open time; secondly, verification using the binary MLC pattern used in a ..
  48. Sughimoto K, Okauchi K, Zannino D, Brizard C, Liang F, Sugawara M, et al. Total Cavopulmonary Connection is Superior to Atriopulmonary Connection Fontan in Preventing Thrombus Formation: Computer Simulation of Flow-Related Blood Coagulation. Pediatr Cardiol. 2015;36:1436-41 pubmed publisher
    ..of thrombus formation in the Fontan route by using a two-dimensional computer hemodynamic simulation based on a simple blood coagulation rule. Hemodynamics in the Fontan route was simulated with Navier-Stokes equations...
  49. Zhang J, Yang F, Chai L, Zhang L, Qu J, Chen T. Spectral measurement of acceptor-to-donor extinction coefficient ratio in living cells. Micron. 2015;68:98-106 pubmed publisher
    This report presents a simple method named as sp-ECR to determine the molar extinction coefficient ratio (γ(λex)) of acceptor-to-donor in living cells at excitation wavelength λex, which is closely associated with the acceptor ..
  50. Zheng D, Lu J, Jefferson A, Zhang C, Wu J, Sleeman W, et al. A protocol to extend the longitudinal coverage of on-board cone-beam CT. J Appl Clin Med Phys. 2012;13:3796 pubmed publisher
    ..Three different approaches were explored to handle the possible misalignment between the two image subsets: simple stacking, averaging the overlapped volumes, and a 3D-3D image registration with the three translational degrees of ..
  51. Johnson D, Weston S, Cosgrove V, Thwaites D. A simple model for predicting the signal for a head-mounted transmission chamber system, allowing IMRT in-vivo dosimetry without pretreatment linac time. J Appl Clin Med Phys. 2014;15:4842 pubmed publisher
    ..Having shown that the algorithm works, a new working paradigm is suggested, and the errors that can be detected are outlined. ..
  52. Deshpande S, Xing A, Holloway L, Metcalfe P, Vial P. Dose calibration of EPIDs for segmented IMRT dosimetry. J Appl Clin Med Phys. 2014;15:4895 pubmed publisher
    ..Dose response linearity was measured for open static jaw defined fields and 'simple' segmented IMRT fields for a range of equipment and system settings. Six 'simple' segmented IMRT fields were used...
  53. Hedin E, Bäck A. Influence of different dose calculation algorithms on the estimate of NTCP for lung complications. J Appl Clin Med Phys. 2013;14:127-39 pubmed publisher
    ..of this work was to determine how to change the NTCP model parameters for lung complications derived for a simple correction-based pencil beam dose calculation algorithm, in order to make them valid for three other common dose ..
  54. Mayoral A, Anderson P, Diaz I. Zeolites are no longer a challenge: atomic resolution data by aberration-corrected STEM. Micron. 2015;68:146-151 pubmed publisher
    ..Unfortunately, extracting all this valuable information is not simple as most materials in one way or another are affected by the strong and localized electron beam...
  55. Crop F, Bernard A, Reynaert N. Improving dose calculations on tomotherapy MVCT images. J Appl Clin Med Phys. 2012;13:3986 pubmed publisher
    ..Applying the proposed transformations and the model, the correct IVDT of the moment can be reconstructed, with a simple measurement in the morning, and corrected with DR changes during the day...
  56. Schreibmann E, Fox T. Prior-knowledge treatment planning for volumetric arc therapy using feature-based database mining. J Appl Clin Med Phys. 2014;15:4596 pubmed publisher
    ..from a near-optimal solution and using previous optimization constraints, the best matching test only required simple optimization steps to further decrease target inhomogeneity, ultimately reducing time spend by the therapist in ..
  57. Webber K, Davies A, Cowie M. Accuracy of a Diagnostic Algorithm to Diagnose Breakthrough Cancer Pain as Compared With Clinical Assessment. J Pain Symptom Manage. 2015;50:495-500 pubmed publisher
    ..There are no comparative data to support use. To compare the diagnostic ability of a simple algorithm against a comprehensive clinical assessment to diagnose BTCP and to assess if verbal rating descriptors ..
  58. Xu Y, Tian Y, Dai J. A simple method to prolong the service life of radioactive sources for external radiotherapy. J Appl Clin Med Phys. 2014;15:4789 pubmed publisher
    ..In this study, a simple method is proposed to prolong its service life...
  59. Gillis A, Mahillon J. An improved method for rapid generation and screening of Bacillus thuringiensis phage-resistant mutants. J Microbiol Methods. 2014;106:101-3 pubmed publisher
    A simple method to isolate, screen and select phage-resistant mutants of Bacillus thuringiensis was developed...
  60. Walker K, Goodman S. How Do Intimate Partner Violent Men Talk About Self-Control?. J Interpers Violence. 2015;: pubmed
    ..Talk about self-control however was not as simple as this suggests because of particular note is the situation where perpetrators offered varying levels of self-..
  61. Zhong W, Lu S, Chai Y. Distally Based Saphenous Neurocutaneous Perforator Flap: A Versatile Donor Site for Reconstruction of Soft Tissue Defects of the Medial Malleolar Region. J Foot Ankle Surg. 2016;55:391-6 pubmed publisher
    Repair of both simple and complex defects in the medial malleolar region continues to be a challenging task for surgeons because of the local paucity of soft tissue available for transfer...
  62. Zhou W, Xie Y. Interactive contour delineation and refinement in treatment planning of image-guided radiation therapy. J Appl Clin Med Phys. 2014;15:4499 pubmed publisher
    ..It allows users to quickly improve contours by a simple mouse click...
  63. Wu M, Ramaseshan R. An approach for measuring the spatial orientations of a computed-tomography simulation system. J Appl Clin Med Phys. 2014;15:4544 pubmed publisher
    ..We proposed a simple and efficient approach to acquire the angular deviations of spatial orientations between these components...
  64. Shimohigashi Y, Araki F, Tominaga H, Sakata J, Kawasaki K, Kanetake N, et al. Angular dependence correction of MatriXX and its application to composite dose verification. J Appl Clin Med Phys. 2012;13:3856 pubmed publisher
    ..The corrected MatriXX were validated with different fields, various simple plans, and clinical treatment plans. The dose distributions were compared with those of MC calculations and film...
  65. Moskvin V, Cheng C, Fanelli L, Zhao L, Das I. A semi-empirical model for the therapeutic range shift estimation caused by inhomogeneities in proton beam therapy. J Appl Clin Med Phys. 2012;13:3631 pubmed publisher
    The purpose of this study was to devise a simple semi-empirical model to estimate the range shift in clinical practices with high-Z inhomogeneity in proton beam...
  66. Shapovalov V. The interaction of electric field and hydrostatic pressure in an electrical double layer: A simple "first principle" model that accounts for the finite sizes of counterions. J Colloid Interface Sci. 2015;454:187-91 pubmed publisher
    A simple model describing the influence of ion size in the electrical double layer (EDL) near a highly charged plane is proposed here...
  67. Balaz P, Rokosny S, Klein D, Adamec M. Aneurysmorrhaphy is an easy technique for arteriovenous fistula salvage. J Vasc Access. 2008;9:81-4 pubmed
    ..This paper describes a simple and inexpensive technique of managing an AVF pseudoaneurysm, i.e. aneurysmorrhaphy...
  68. Inomura K, Bragg J, Follows M. A quantitative analysis of the direct and indirect costs of nitrogen fixation: a model based on Azotobacter vinelandii. ISME J. 2017;11:166-175 pubmed publisher
    ..The latter mechanisms lead to higher growth efficiencies relative to respiratory protection alone. This simple, yet mechanistic framework provides a quantitative model of nitrogen fixation, which can be applied in ecological ..
  69. Silvestri A, Cistrone P, Dawson P. Adapting the Glaser Reaction for Bioconjugation: Robust Access to Structurally Simple, Rigid Linkers. Angew Chem Int Ed Engl. 2017;56:10438-10442 pubmed publisher
    ..The generality of this method is illustrated through the conjugation of a series of polar and nonpolar labels onto a fully unprotected GLP-1R agonist through a linear 7?Å diynyl linker...
  70. Planz V, Wang J, Windbergs M. Establishment of a cell-based wound healing assay for bio-relevant testing of wound therapeutics. J Pharmacol Toxicol Methods. 2018;89:19-25 pubmed publisher
    ..b>Simple "scratch tests" based on defected skin cell monolayers exist, however these can solely be used for testing liquids,..
  71. Kortyna A, Samin A, Miller T, Nesbitt D. Sub-Doppler infrared spectroscopy of resonance-stabilized hydrocarbon intermediates: ?3/?4 CH stretch modes and CH2 internal rotor dynamics of benzyl radical. Phys Chem Chem Phys. 2017;19:29812-29821 pubmed publisher
    ..In summary, the high-resolution infrared spectra are in excellent agreement with simple physical organic chemistry pictures of a strongly resonance-stabilized benzyl radical with a nearly rigid planar ..
  72. Zhang H, Zhao X, Liu S, Yang J, Duan R, Yuan Y, et al. Determination of Sunset Yellow Based on Its Quenching Effect on the Fluorescence of Acridine Orange. Anal Sci. 2017;33:243-247 pubmed publisher
    ..008 - 9.0 ?mol L-1. Herein, this finding was utilized to develop a new strategy for simple, rapid, sensitive and selective detection of SY by combining AO based on fluorescence quenching...
  73. Opazo Navarrete M, Schutyser M, Boom R, Janssen A. Effect of pre-treatment on in vitro gastric digestion of quinoa protein (Chenopodium quinoa Willd.) obtained by wet and dry fractionation. Int J Food Sci Nutr. 2018;69:1-11 pubmed publisher
    ..QPC showed significantly higher (p?<?.05) digestibility than QPI samples. The results were interpreted with a simple double exponential model. The fraction of easily digested protein in QPC is higher than for QPI...
  74. Chen J, Penn L, Xi J. Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond. Biosens Bioelectron. 2018;99:593-602 pubmed publisher
    ..crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool...
  75. Siddiq M, Hochberg G, Thornton J. Evolution of protein specificity: insights from ancestral protein reconstruction. Curr Opin Struct Biol. 2017;47:113-122 pubmed publisher
    ..Further, the new specific interactions evolved by simple mechanisms, with just a few mutations changing classically recognized biochemical determinants of specificity, ..
  76. Luo Q, Cao F, Xiong C, Dou Q, Qu D. Hybrid cis/trans Tetra-arylethenes with Switchable Aggregation-Induced Emission (AIE) and Reversible Photochromism in the Solution, PMMA Film, Solid Powder, and Single Crystal. J Org Chem. 2017;82:10960-10967 pubmed publisher
    ..In this presentation, we devote to constructing a kind of simple structures with composite functionalities through straightforward preparation...
  77. Haußmann A. Light scattering from sessile water drops and raindrop-shaped glass beads as a validation tool for rainbow simulations. Appl Opt. 2017;56:G136-G144 pubmed publisher
    ..To check the accuracy of numerical optical models for rainbow scattering from such nonspherical drops, two simple and low-cost experiments are presented in this paper: (1) sessile, i.e...
  78. Pan A, Jurow M, Zhao Y, Qiu F, Liu Y, Yang J, et al. Templated self-assembly of one-dimensional CsPbX3 perovskite nanocrystal superlattices. Nanoscale. 2017;9:17688-17693 pubmed publisher
    ..Here we investigated a simple kinetic approach to form self-assembled one-dimensional perovskite CsPbX3 (X: halides) nanocrystal ..
  79. Diner I, Nguyen T, Seyfried N. Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain. J Vis Exp. 2017;: pubmed publisher
    ..Thus, this simple enrichment protocol is ideal for a wide range of experimental applications ranging from Western blotting and ..
  80. Delesma F, Van den Bossche M, Grönbeck H, Calaminici P, Koster A, Pettersson L. A Chemical View on X-ray Photoelectron Spectroscopy: the ESCA molecule and surface-to-bulk XPS shifts. Chemphyschem. 2017;: pubmed publisher
    In this paper we remind the reader of a simple, intuitive picture of chemical shifts in x-ray photoelectron spectroscopy (XPS) as the difference in chemical bonding between the probed atom and its neighbor to the right in the periodic ..
  81. Mesquita A, Cardenal Muñoz E, Dominguez E, Muñoz Braceras S, Núñez Corcuera B, Phillips B, et al. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy. 2017;13:24-40 pubmed publisher
    ..Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum...
  82. Cheng Y, Zhang P, Jia Y, Fang Z, Li P. Organocatalytic condensation-ring opening-annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins. Org Biomol Chem. 2017;15:7505-7508 pubmed publisher
    ..This method was featured by a broad scope of reactants, mild conditions, and simple operation.
  83. Ch ng S, Andriyana A, Tee Y, Verron E. Effects of Carbon Black and the Presence of Static Mechanical Strain on the Swelling of Elastomers in Solvent. Materials (Basel). 2015;8:884-898 pubmed publisher
    ..of carbon black content on the swelling of elastomers in solvent in the presence of static mechanical strains: simple extension and simple torsion...
  84. Aghaeepour N, Kin C, Ganio E, Jensen K, Gaudilliere D, Tingle M, et al. Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery. J Immunol. 2017;: pubmed publisher
    ..framework to distill high-dimensional datasets gathered in an interventional clinical trial into a fairly simple model that converges with known biology and provides insight into novel and clinically relevant cellular ..
  85. Foroutan T, Nazemi N, Tavana M, Kassaee M, Motamedi E, Soieshargh S, et al. Suspended graphene oxide nanoparticle for accelerated multilayer osteoblast attachment. J Biomed Mater Res A. 2018;106:293-303 pubmed publisher
    ..In this study, we proposed a simple technique for assembly of cells that facilitates the construction of osteoblast-like structures using suspended GO ..
  86. Korobko D, Fotiadi A, Zolotovskii I. Mode-locking evolution in ring fiber lasers with tunable repetition rate. Opt Express. 2017;25:21180-21190 pubmed publisher
    We have applied a simple approach to analyze behavior of the harmonically mode-locked fiber laser incorporating an adjustable Mach-Zehnder interferometer (MZI)...
  87. Auslender I, Barmashenko B, Rosenwaks S. Multi-transverse mode operation of alkali vapor lasers: modeling and comparison with experiments. Opt Express. 2017;25:19767-19779 pubmed publisher
    ..A simple optical model of multi-transverse mode operation of alkali vapor lasers is reported...
  88. Hatfield M, Reilhac C, Cowley H, Chang E, McCloskey M. Cognitive processes in spatial mapping: Evidence from a developmental spatial deficit. Cogn Neuropsychol. 2017;:1-18 pubmed publisher
    ..K.Y.) with a developmental deficit affecting spatial processing. In a simple spatial mapping task, N.K.Y...
  89. Thomas K, Marsiske M. Age trajectories of everyday cognition in African American and White older adults under prompted and unprompted conditions. Neuropsychol Rehabil. 2017;27:522-539 pubmed publisher
    ..b>Simple prompting attenuated age-related changes of African Americans and Whites on a measure of everyday cognition...
  90. Garabon J, Higgs D. The effects of stimulus parameters on auditory evoked potentials of Carassius auratus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017;203:945-951 pubmed publisher
    ..The effect of varying parameters is especially unclear in fish studies, the majority of which use simple sound types and then extrapolate to natural conditions...
  91. Johnson J, Michl J. 1,3-Diphenylisobenzofuran: a Model Chromophore for Singlet Fission. Top Curr Chem (Cham). 2017;375:80 pubmed publisher
    ..In the last section we present the operation of a simple device illustrating the use of triplets generated by singlet fission for charge separation.
  92. Feng X, Xiang P, Chen H, Shen M. LC-MS-MS with Post-Column Reagent Addition for the Determination of Zolpidem and its Metabolite Zolpidem Phenyl-4-carboxylic Acid in Oral Fluid after a Single Dose. J Anal Toxicol. 2017;:1-9 pubmed publisher
    ..Preliminary sample treatment was limited to a simple dilution of 1 mL oral fluid specimen aliquots with methanol...