lipoprotein lipase

Summary

Gene Symbol: lipoprotein lipase
Description: lipoprotein lipase
Alias: HDLCQ11, LIPD, lipoprotein lipase
Species: human
Products:     lipoprotein lipase

Top Publications

  1. Jinno Y, Nakakuki M, Kawano H, Notsu T, Mizuguchi K, Imada K. Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages. Atherosclerosis. 2011;219:566-72 pubmed publisher
    ..Inhibition of lipoprotein lipase (LPL) appeared to suppress inflammation and triglyceride accumulation by Ctrl-VLDL suggesting that ..
  2. Xu E, Li W, Zhan L, Guan G, Wang X, Chen S, et al. Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese. Neuroscience. 2008;155:403-8 pubmed publisher
    b>Lipoprotein lipase (LPL), which plays an essential role in plasma lipoprotein metabolism and transportation, appears to be a risk factor for ischemic vascular diseases...
  3. Surendran R, Visser M, Heemelaar S, Wang J, Peter J, Defesche J, et al. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med. 2012;272:185-96 pubmed publisher
    ..forms of hypertriglyceridaemia (HTG) are caused by mutations in genes that lead to the loss of function of lipoprotein lipase (LPL)...
  4. Wittrup H, Andersen R, Tybjaerg Hansen A, Jensen G, Nordestgaard B. Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study. J Clin Endocrinol Metab. 2006;91:1438-45 pubmed
    Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  5. Kooner J, Chambers J, Aguilar Salinas C, Hinds D, Hyde C, Warnes G, et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet. 2008;40:149-51 pubmed publisher
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'. ..
  6. Chen Q, RAZZAGHI H, Demirci F, Kamboh M. Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease. Atherosclerosis. 2008;200:102-8 pubmed publisher
    b>Lipoprotein lipase (LPL) plays a pivotal role in lipid metabolism by hydrolyzing triglyceride (TG)-rich lipoprotein particles. Abnormalities in normal LPL function are associated with the risk of coronary artery disease (CAD)...
  7. Rahalkar A, Giffen F, Har B, Ho J, Morrison K, Hill J, et al. Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review. Can J Physiol Pharmacol. 2009;87:151-60 pubmed publisher
    b>Lipoprotein lipase (LPL) is a key enzyme involved with hydrolysis and removal of triglycerides from plasma. LPL deficiency is a rare condition with an estimated prevalence of 1 in 106...
  8. Radha V, Mohan V, Vidya R, Ashok A, Deepa R, Mathias R. Association of lipoprotein lipase Hind III and Ser 447 Ter polymorphisms with dyslipidemia in Asian Indians. Am J Cardiol. 2006;97:1337-42 pubmed
    Studies have shown an association between the lipoprotein lipase gene and dyslipidemia and atherosclerosis in some populations...
  9. Chan A, But W, Lau G, Tse W, Shek C. A novel nonsense mutation in the LPL gene in a Chinese neonate with hypertriglyceridemia. Clin Chim Acta. 2006;368:120-4 pubmed
    b>Lipoprotein lipase (LPL) deficiency is a rare autosomal recessive disorder characterized by hypertriglyceridemia. The genetic defect lies in a mutation of the LPL gene...

More Information

Publications65

  1. Johansen C, Wang J, Lanktree M, Cao H, McIntyre A, Ban M, et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010;42:684-7 pubmed publisher
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG. ..
  2. Kraja A, Vaidya D, Pankow J, Goodarzi M, Assimes T, Kullo I, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011;60:1329-39 pubmed publisher
    ..4% of systolic blood pressure. CONCLUSIONS Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants. ..
  3. Goodarzi M, Wong H, Quiñones M, Taylor K, Guo X, Castellani L, et al. The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity. J Clin Endocrinol Metab. 2005;90:4816-23 pubmed
    Haplotypes comprising six single nucleotide polymorphisms (SNPs) (intron 7 to intron 9) of the lipoprotein lipase (LPL) gene appear to influence risk for atherosclerosis and insulin resistance in Mexican-Americans...
  4. Huang X, Gong R, Lin J, Li R, Xiao L, Duan W, et al. Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth. Biosci Trends. 2011;5:198-204 pubmed
    A high-carbohydrate low-fat (HC/LF) diet and lipoprotein lipase gene (LPL) Ser447Stop and Hind III polymorphisms have separately been found to be associated with triacylglycerol (TG) and high density lipoprotein cholesterol (HDL-C)...
  5. Lee J, Tan C, Chia K, Tan C, Chew S, Ordovas J, et al. The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption. J Lipid Res. 2004;45:1132-9 pubmed
    ..Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest. ..
  6. Ranganathan G, Unal R, Pokrovskaya I, Tripathi P, Rotter J, Goodarzi M, et al. The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation. Atherosclerosis. 2012;221:143-7 pubmed publisher
    ..These studies suggest that the LPLS447X gain of function may be due to the base change in the LPL mRNA resulting in a decreased susceptibility to translational inhibition. ..
  7. Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, et al. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis. 2005;179:87-95 pubmed
    b>Lipoprotein lipase (LPL) produced by macrophages is upregulated in the atherosclerotic lesions; however, it is not fully understood whether increased macrophage-derived LPL is pro-atherogenic...
  8. Mead J, Irvine S, Ramji D. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med (Berl). 2002;80:753-69 pubmed
    b>Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation...
  9. Kathiresan S, Manning A, Demissie S, D Agostino R, Surti A, Guiducci C, et al. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet. 2007;8 Suppl 1:S17 pubmed
    ..Some results confirmed previously reported associations with candidate genes including variation in the lipoprotein lipase gene (LPL) and HDL-C and TG (rs7007797; P = 0.0005 for HDL-C and 0.002 for TG)...
  10. Abu Amero K, Wyngaard C, Al Boudari O, Kambouris M, Dzimiri N. Lack of association of lipoprotein lipase gene polymorphisms with coronary artery disease in the Saudi Arab population. Arch Pathol Lab Med. 2003;127:597-600 pubmed
    Previous studies reported an association of certain polymorphisms in the lipoprotein lipase (LPL) gene with the risk of coronary artery disease (CAD); however, these studies were small and inconsistent...
  11. Komurcu Bayrak E, Onat A, Poda M, Humphries S, Acharya J, Hergenc G, et al. The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks. Clin Chim Acta. 2007;383:110-5 pubmed
    We evaluated the relationship of the lipoprotein lipase (LPL) S447X variant with serum lipid levels and the metabolic syndrome (MS) in the Turkish Adult Risk Factor (TARF) study...
  12. Kostomarov I, Vodolagina N, Malygina N, Mitina Z. [The relation between gene of lipoprotein-lipase and carrier protein of cholesterol ethers and life duration in patients with chronic cerebral ischemia]. Klin Med (Mosk). 2008;86:22-6 pubmed
  13. Skoglund Andersson C, Ehrenborg E, Fisher R, Olivecrona G, Hamsten A, Karpe F. Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men. Atherosclerosis. 2003;167:311-7 pubmed
    ..Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE e2/e3/e4) genes were studied in relation ..
  14. Deo R, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, et al. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009;5:e1000342 pubmed publisher
    ..profiles -- HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and triglycerides (TG) -- we identified the lipoprotein lipase (LPL) locus as harboring variants that account for interethnic variation in HDL-C and TG...
  15. Smith A, Palmen J, Putt W, Talmud P, Humphries S, Drenos F. Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar. Hum Mol Genet. 2010;19:3936-47 pubmed publisher
    ..In this paper, we describe a methodology to locate and validate candidate functional SNPs using lipoprotein lipase (LPL), a gene previously associated with triglyceride levels, as an exemplar...
  16. Heintel D, Kienle D, Shehata M, Krober A, Kroemer E, Schwarzinger I, et al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. Leukemia. 2005;19:1216-23 pubmed
    We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly restricted to leukemic B cells...
  17. Rebhi L, Kchok K, Omezzine A, Kacem S, Rejeb J, Ben Hadjmbarek I, et al. Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population. Mol Biol Rep. 2012;39:9893-901 pubmed
    b>Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of triglyceride-rich lipoprotein particles (Chylomicrons and very-low-density lipoprotein)...
  18. Jensen M, Rimm E, Rader D, Schmidt E, Sørensen T, Vogel U, et al. S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies. Am Heart J. 2009;157:384-90 pubmed publisher
    b>Lipoprotein lipase (LPL) has a prominent role in the metabolism of triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) and is a potential interesting target for the development of antiatherogenic treatment...
  19. Lanktree M, Anand S, Yusuf S, Hegele R. Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample. J Lipid Res. 2009;50:1487-96 pubmed publisher
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples. ..
  20. Kim J, Cheng Y, Liu W, Li T, Yegnasubramanian S, Zheng S, et al. Genetic and epigenetic inactivation of LPL gene in human prostate cancer. Int J Cancer. 2009;124:734-8 pubmed publisher
    b>Lipoprotein lipase (LPL) is in chromosome 8p22, site of one of the most common somatic deletions in prostate tumors. Additionally, a CpG island (CGI) was identified in the LPL promoter region...
  21. Xian X, Liu T, Yu J, Wang Y, Miao Y, Zhang J, et al. Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice. J Neurosci. 2009;29:4681-5 pubmed publisher
    b>Lipoprotein lipase (LPL) is predominantly expressed in adipose and muscle where it plays a crucial role in the metabolism of triglyceride-rich plasma lipoproteins...
  22. Tang W, Apostol G, Schreiner P, Jacobs D, Boerwinkle E, Fornage M. Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Circ Cardiovasc Genet. 2010;3:179-86 pubmed publisher
    ..studies in European Americans have reported several single-nucleotide polymorphisms (SNPs) in the lipoprotein lipase gene associated with plasma levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides...
  23. Munshi A, Babu M, Kaul S, Rajeshwar K, Balakrishna N, Jyothy A. Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes. J Neurol Sci. 2012;318:51-4 pubmed publisher
    b>Lipoprotein lipase (LPL) plays an important role in lipid metabolism by hydrolyzing triglycerides in chylomicrons and very low density lipoproteins...
  24. Makoveichuk E, Sukonina V, Kroupa O, Thulin P, Ehrenborg E, Olivecrona T, et al. Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed. Biochem Biophys Res Commun. 2012;425:138-43 pubmed publisher
    b>Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue...
  25. Yang W, Huang J, Ge D, Yao C, Duan X, Gan W, et al. Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese. Hypertens Res. 2003;26:459-64 pubmed
    Essential hypertension (EH) is a common late-onset disease that exhibits complex genetic heterogeneity. Human lipoprotein lipase (LPL) is a rate-limiting enzyme that regulates the catabolism of triglycerides (TG) and chylomicrons (CM)...
  26. Gigek C, Chen E, Cendoroglo M, Ramos L, Araujo L, Payão S, et al. Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels. Clin Chem Lab Med. 2007;45:599-604 pubmed
    b>Lipoprotein lipase has an important role in lipid metabolism...
  27. Duman B, Turkoglu C, Akpinar B, Guden M, Vertii A, Dak E, et al. Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease. Arch Pathol Lab Med. 2004;128:869-74 pubmed
    b>Lipoprotein lipase (LPL) plays a central role in lipid metabolism, hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins...
  28. Descamps O, Bruniaux M, Guilmot P, Tonglet R, Heller F. Lipoprotein metabolism of pregnant women is associated with both their genetic polymorphisms and those of their newborn children. J Lipid Res. 2005;46:2405-14 pubmed
  29. Frikke Schmidt R, Sing C, Nordestgaard B, Steffensen R, Tybjaerg Hansen A. Subsets of SNPs define rare genotype classes that predict ischemic heart disease. Hum Genet. 2007;120:865-77 pubmed
    ..In this study we determined the utility of exonic and 5' SNPs in apolipoprotein E (APOE) and lipoprotein lipase (LPL) when considered singly and in combination for predicting incidence of IHD in 8,456 individuals from ..
  30. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt N, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-9 pubmed publisher
    ..The score did not improve risk discrimination but did modestly improve clinical risk reclassification for individual subjects beyond standard clinical factors. ..
  31. Paradis E, Clément S, Julien P, Ven Murthy M. Lipoprotein lipase affects the survival and differentiation of neural cells exposed to very low density lipoprotein. J Biol Chem. 2003;278:9698-705 pubmed
    b>Lipoprotein lipase (LPL) is a key enzyme involved in the metabolism of lipoproteins, providing tissues like adipose tissue or skeletal muscle with fatty acids. LPL is also expressed in the brain, fulfilling yet unknown functions...
  32. Goodarzi M, Guo X, Taylor K, Quiñones M, Saad M, Yang H, et al. Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes. 2004;53:214-20 pubmed
    The insulin resistance syndrome is increasingly recognized as a risk factor for cardiovascular disease. Lipoprotein lipase (LPL) is a candidate gene for components of the syndrome...
  33. Xie C, Wang Z, Liu X, Wang L, Yang M. Association between schizophrenia and single nucleotide polymorphisms in lipoprotein lipase gene in a Han Chinese population. Psychiatr Genet. 2011;21:307-14 pubmed publisher
    ..b>Lipoprotein lipase (LPL), as the key enzyme of triglyceride hydrolysis, is expressed in the brain regions functionally relevant ..
  34. Chen P, Jou Y, Fann C, Chen J, Wu S, Pan W. Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study. J Biomed Sci. 2005;12:651-8 pubmed
    ..However, the mechanism behind it is poorly understood. A positive linkage signal between Lipoprotein lipase (LPL) and young-onset hypertension has been identified by us as the strongest among 18 candidate genes...
  35. Hieronimus S, Benlian P, Bayer P, Bongain A, Fredenrich A. Combination of apolipoprotein E2 and lipoprotein lipase heterozygosity causes severe hypertriglyceridemia during pregnancy. Diabetes Metab. 2005;31:295-7 pubmed
    ..of marked hypertriglyceridemia (HTG) is rare and may result from combination of heterozygote mutation in the lipoprotein lipase (LPL) gene and apolipoprotein E2 isoform, as reported in this case...
  36. Hu Y, Liu W, Huang R, Zhang X. A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases. J Lipid Res. 2006;47:1908-14 pubmed
    This systematic review attempted to summarize the associations between the Asn291Ser variant in the lipoprotein lipase (LPL) gene and dyslipidemia, the risk of type 2 diabetes mellitus (T2DM), and coronary heart disease (CHD)...
  37. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies. ..
  38. Saxena R, Voight B, Lyssenko V, Burtt N, de Bakker P, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331-6 pubmed
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. ..
  39. Wang J, Cao H, Ban M, Kennedy B, Zhu S, Anand S, et al. Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650). Arterioscler Thromb Vasc Biol. 2007;27:2450-5 pubmed
    ..The findings underscore the value of candidate gene resequencing to understand the genetic contribution in complex lipoprotein and metabolic disorders. ..
  40. Chambers J, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 2008;40:716-8 pubmed publisher
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance. ..
  41. Almeida K, Strunz C, Maranhão R, Mansur A. The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. Arq Bras Cardiol. 2007;88:297-303 pubmed
    ..The S447X polymorphism of lipoprotein lipase is related to a decrease in plasma triglyceride concentrations in male patients with CAD, but this ..
  42. Sonnenburg W, Yu D, Lee E, Xiong W, GOLOLOBOV G, Key B, et al. GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4. J Lipid Res. 2009;50:2421-9 pubmed publisher
    ..Moreover, therapeutic agents that prevent LPL inhibition by ANGPTL4 or, to a lesser extent, ANGPTL3, may benefit individuals with hyperlipidemia caused by gene mutations associated with decreased LPL stability. ..
  43. Qiu G, Ho A, Yu W, Hill J. Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion. J Lipid Res. 2007;48:385-94 pubmed
    ..These results provide further insight into the specific metabolic and potential pathological roles of LPL and EL in human macrophages. ..
  44. Blain J, Aumont N, Theroux L, Dea D, Poirier J. A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology. Eur J Neurosci. 2006;24:1245-51 pubmed
    Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states...
  45. Agirbasli M, Sumerkan M, Eren F, Agirbasli D. The S447X variant of lipoprotein lipase gene is inversely associated with severity of coronary artery disease. Heart Vessels. 2011;26:457-63 pubmed publisher
    Hyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is an important enzyme in lipoprotein metabolism. S447X polymorphism of the LPL gene has been implicated in the pathogenesis of CAD...
  46. Brisson D, St Pierre J, Santure M, Hudson T, Despres J, Vohl M, et al. Genetic epistasis in the VLDL catabolic pathway is associated with deleterious variations on triglyceridemia in obese subjects. Int J Obes (Lond). 2007;31:1325-33 pubmed
    ..Only gene variants in the lipoprotein lipase, apolipoprotein (apo) CIII, hepatic lipase and apo E genes known to be frequent in the general population (..
  47. Wung S, Kulkarni M, Pullinger C, Malloy M, Kane J, Aouizerat B. The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion. Lipids Health Dis. 2006;5:19 pubmed
    b>Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins...
  48. Middelberg R, Ferreira M, Henders A, Heath A, Madden P, Montgomery G, et al. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genet. 2011;12:123 pubmed publisher
    ..Our study demonstrated the usefulness of examining multiple phenotypes jointly and highlights an anomalous effect on CRP, which is increasingly recognised as a marker of cardiovascular risk as well as of inflammation. ..
  49. Sagoo G, Tatt I, Salanti G, Butterworth A, Sarwar N, van Maarle M, et al. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol. 2008;168:1233-46 pubmed publisher
    b>Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD)...
  50. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects. ..
  51. Tan A, Sun J, Xia N, Qin X, Hu Y, Zhang S, et al. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet. 2012;21:1658-64 pubmed publisher
    ..Just one drink can increase TG level in susceptible individuals who carry the GG genotype, while individuals carrying AA/AG genotypes may actually benefit from moderate drinking. ..
  52. Pasalic D, Jurcic Z, Stipancic G, Ferencak G, Leren T, Djurovic S, et al. Missense mutation W86R in exon 3 of the lipoprotein lipase gene in a boy with chylomicronemia. Clin Chim Acta. 2004;343:179-84 pubmed
    ..LPL genotyping especially of young patients with hypertriglyceridemia is therefore necessary and justifiable. ..
  53. Choumerianou D, Maumus S, Skoumas J, Pitsavos C, Stefanadis C, Visvikis Siest S, et al. Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia. Clin Chem Lab Med. 2006;44:799-806 pubmed
    ..We investigated paraoxonase 2 (PON 2) Ser311Cys, lipoprotein lipase (LPL) Asn291Ser, plasminogen activator inhibitor-1 (PAI-1) T11053G, beta-fibrinogen (FGB) -455 G>A and ..
  54. Goodarzi M, Guo X, Taylor K, Quiñones M, Samayoa C, Yang H, et al. Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans. Genet Med. 2003;5:322-7 pubmed
    To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease...
  55. Mansouri M, Sevov M, Fahlgren E, Tobin G, Jondal M, Osorio L, et al. Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity. Leuk Res. 2010;34:301-6 pubmed publisher
    b>Lipoprotein lipase (LPL) expression has been shown to correlate with IGHV mutational status and to predict outcome in chronic lymphocytic leukemia (CLL)...
  56. Smith C, Tucker K, Lai C, Parnell L, Lee Y, Ordovas J. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity (Silver Spring). 2010;18:327-32 pubmed publisher
    Apolipoprotein A5 (APOA5) and lipoprotein lipase (LPL) proteins interact functionally to regulate lipid metabolism, and single-nucleotide polymorphisms (SNPs) for each gene have also been associated independently with obesity risk...