LIPH

Summary

Gene Symbol: LIPH
Description: lipase, member H
Alias: ARWH2, LAH2, LPDLR, PLA1B, mPA-PLA1, LPD lipase-related protein, lipase H, lipase member H, mPA-PLA1 alpha, membrane-associated phosphatidic acid-selective phospholipase A1-alpha, membrane-bound phosphatidic acid-selective phospholipase A1, phospholipase A1 member B
Species: human

Top Publications

  1. ncbi Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family
    Stephane Canaan
    Architecture et Fonction des Macromolecules Biologiques, AFMB UMR 6098, CNRS, 13402 Marseille, France
    Eur J Biochem 271:3953-61. 2004
  2. doi Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant
    Takumi Abe
    Department of Neurosurgery, Showa University School of Medicine, 5 8 Hatanodai 1, Shinagawa ku, Tokyo 142 8666, Japan
    Brain Tumor Pathol 25:59-66. 2008
  3. doi Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis
    Satoru Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:602-10. 2010
  4. ncbi A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2)
    M Jelani
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Clin Genet 74:184-8. 2008
  5. doi Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan
    S Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad, Pakistan
    Clin Exp Dermatol 36:652-4. 2011
  6. pmc LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling
    Asuka Inoue
    Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan or
    EMBO J 30:4248-60. 2011
  7. doi Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis
    Yutaka Shimomura
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Invest Dermatol 129:622-8. 2009
  8. pmc A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33-q27.3
    M Aslam
    J Med Genet 41:849-52. 2004
  9. ncbi A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis
    Ghazanfar Ali
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Hum Genet 121:319-25. 2007
  10. pmc Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations
    Kana Tanahashi
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 9:e89261. 2014

Research Grants

Scientific Experts

  • Joakim Klar
  • R C Betz
  • Masashi Akiyama
  • Y Shimomura
  • Frank Rosenau
  • Junken Aoki
  • Kan Sato
  • X Y Wen
  • D J Tobin
  • M T Reetz
  • Takumi Abe
  • Amy Halverstadt
  • Sandra M Pasternack
  • Asuka Inoue
  • Virgil Brown
  • Mathieu Diribarne
  • Naoaki Arima
  • W Ahmad
  • Ghazanfar Ali
  • Meizi Cui
  • Kana Tanahashi
  • Yasuhiro Seki
  • Madhu Sudhan Ravindran
  • Hiroyuki Arai
  • Laura Grisanti
  • Kuppuswamy Ashok Ayyappa
  • K Tanahashi
  • Kazutoshi Harada
  • M Kurban
  • Manuela Hesse
  • Atsushi Fujimoto
  • Alicia Rodriguez
  • Toshiro Seki
  • Hassnaa Mahmoudi
  • Muhammad Tariq
  • Shaan L Gellatly
  • Gérard Guérin
  • Anne Vaiman
  • Séverine Deretz
  • Stephan Bouet
  • Gérard Auvinet
  • Xavier Mata
  • Daniel Allain
  • Edmond Paul Cribiu
  • S Khan
  • S Nahum
  • Takashi Yoshimasu
  • Sayed Hajan Shah
  • Satoru Shinkuma
  • Benjamin F Wicker
  • N Wasif
  • G Ali
  • Sagi Nahum
  • Liran Horev
  • Markus M Nothen
  • Gul Naz
  • Tatsufumi Hiramatsu
  • Melanie Muller
  • Eli Sprecher
  • Lynn Petukhova
  • Hirofumi Sonoda
  • Daniel J Mindiola
  • Wasim Ahmad
  • M Jelani
  • Kyoung Sik Han
  • Susanne Wilhelm
  • Juan Andres Rivera
  • Anastasiya Kazantseva
  • Guangyu Zhao
  • M Aslam
  • Stephane Canaan
  • Mayuko Ishida
  • Ryo Taguchi
  • Xiumin Shi
  • Karen D Larbig
  • Makoto Asashima
  • Chao Niu
  • Xiaobo Ding
  • Nobuyuki Hamajima
  • Aya Shinozaki-Ushiku
  • Xiamin Cheng
  • Ankit Shukla
  • Markus R Wenk
  • Yukihiro Yoshida
  • Tatsuo Michiue
  • Hiromichi Takama
  • Akira Kurisaki
  • Yanbo Wang
  • Kazumitsu Sugiura
  • Ge Qu

Detail Information

Publications65

  1. ncbi Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family
    Stephane Canaan
    Architecture et Fonction des Macromolecules Biologiques, AFMB UMR 6098, CNRS, 13402 Marseille, France
    Eur J Biochem 271:3953-61. 2004
    ..Driven by a structural genomic approach, we have biochemically characterized the Rv1399c gene product, LipH, previously annotated as a putative lipase. Rv1399c was overexpressed in E. coli as inclusion bodies and refolded...
  2. doi Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant
    Takumi Abe
    Department of Neurosurgery, Showa University School of Medicine, 5 8 Hatanodai 1, Shinagawa ku, Tokyo 142 8666, Japan
    Brain Tumor Pathol 25:59-66. 2008
    ..Some of them showed partial hypopituitarism. The so-called lymphocytic infundibulo-panhypophysitis (LIPH) is now regarded as a lymphocytic hypophysitis variant. LINH and LIPH are essentially self-limited...
  3. doi Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis
    Satoru Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:602-10. 2010
    ..Three genes, DSG4, LIPH, and LPAR6 (P2RY5), have been reported to underlie ARH...
  4. ncbi A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2)
    M Jelani
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Clin Genet 74:184-8. 2008
    ..clinically similar autosomal recessive forms of hypotrichosis [localized autosomal recessive hypotrichosis (LAH)1], LAH2 and LAH3 have been mapped on chromosomes 18q12.1, 3q27.3, and 13q14.11-q21.32, respectively...
  5. doi Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan
    S Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad, Pakistan
    Clin Exp Dermatol 36:652-4. 2011
    ..This form of hair loss results from mutations in either LPAR6 or LIPH gene.
  6. pmc LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling
    Asuka Inoue
    Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan or
    EMBO J 30:4248-60. 2011
    ..mediated by an LPA-producing enzyme, phosphatidic acid-selective phospholipase A(1)α (PA-PLA(1)α, also known as LIPH), and a recently identified LPA receptor, P2Y5 (also known as LPA(6))...
  7. doi Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis
    Yutaka Shimomura
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Invest Dermatol 129:622-8. 2009
    ..This region contains the lipase H (LIPH) gene which has been recently shown to underlie an autosomal-recessive form of hypotrichosis...
  8. pmc A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33-q27.3
    M Aslam
    J Med Genet 41:849-52. 2004
  9. ncbi A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis
    Ghazanfar Ali
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Hum Genet 121:319-25. 2007
    ..Mutations in desmogelin 4 (DSG4) gene have been reported to underlie LAH. Recently, a deletion mutation in Lipase H (LIPH) gene, located at AH locus, has been identified in two ethnic groups of Russian population...
  10. pmc Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations
    Kana Tanahashi
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 9:e89261. 2014
    Mutations in LIPH cause of autosomal recessive woolly hair/hypotrichosis (ARWH), and the 2 missense mutations c.736T>A (p.Cys246Ser) and c.742C>A (p...
  11. ncbi [Alopecia and hypotrichosis in childhood: clinical features and diagnosis]
    R C Betz
    Institut fur Humangenetik, Biomedizinisches Zentrum BMZ, Universitat Bonn, Sigmund Freud Str 25, 53127, Bonn, Deutschland
    Hautarzt 65:520-6. 2014
    ..the genes CDSN, APCDD1 and SNRPE for the autosomal dominant form of hypotrichosis simplex, and the genes DSG4, LIPH and LPAR6 for the autosomal recessive forms of hypotrichosis as well as U2HR for hypotrichosis type Marie Unna...
  12. ncbi Lipase member H is a novel secreted protein associated with a poor prognosis for breast cancer patients
    Meizi Cui
    Cancer Center, The First Hospital of Jilin University, Changchun, 130000, China
    Tumour Biol . 2014
    The objective of this study is to identify the expression status and clinical implications of lipase member H (LIPH) in breast cancer in order to develop strategies for breast cancer management...
  13. doi Association of hepatic lipase gene polymorphisms with hypertriglyceridemia and low high-density lipoprotein-cholesterol levels among South Indian subjects without diabetes
    Kuppuswamy Ashok Ayyappa
    Madras Diabetes Research Foundation ICMR Advanced Centre for Genomics of Type 2 Diabetes and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non Communicable diseases, IDF Centre for Education, Gopalapuram, Chennai, India
    Diabetes Technol Ther 15:503-12. 2013
    ..The aim of this study was to investigate the association of four variants of the hepatic lipase (HL [or LIPC]) gene with various lipid parameters among South Indian subjects with normal glucose tolerance (NGT)...
  14. doi Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas
    Yasuhiro Seki
    Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Biochem Biophys Res Commun 443:1141-7. 2014
    ..We identified lipase member H (LIPH, also known as mPA-PLA1) as one of the significantly upregulated genes in lung adenocarcinoma...
  15. pmc Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL)
    Madhu Sudhan Ravindran
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456
    Mol Cell Proteomics 13:435-48. 2014
    ..Cellular overexpression of lipH and tesA led to decreased THL susceptibility thus providing functional validation...
  16. pmc Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis
    Laura Grisanti
    1 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    J Invest Dermatol 133:2332-9. 2013
    ..expression, we finally isolate control and Enpp2-null DP precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of ..
  17. ncbi Lymphocytic hypophysitis: disease spectrum and approach to diagnosis and therapy
    Juan Andres Rivera
    Division of Endocrinology, McGill University and McGill University Health Centre, Montreal, Quebec, H3A 1A1, Canada
    Pituitary 9:35-45. 2006
    ..combination of extensive anterior pituitary involvement and DI characterizes lymphocytic Infudibulopanhypophysitis (LIPH)...
  18. doi Two cases of autosomal recessive woolly hair with LIPH gene mutations
    Kazutoshi Harada
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, Chuo shi, Yamanashi, Japan
    Int J Dermatol 52:572-4. 2013
    Woolly hair is a hereditary disorder characterized by fine and tightly curled hair. Autosomal recessive woolly hair (ARWH) was recently determined to result from mutations in either the lipase H (LIPH) or the LPAR6 (P2RY5) gene.
  19. ncbi Neutral and zwitterionic low-coordinate titanium complexes bearing the terminal phosphinidene functionality. Structural, spectroscopic, theoretical, and catalytic studies addressing the Ti-P multiple bond
    Guangyu Zhao
    Department of Chemistry and Molecular Structure Center, Indiana University, Bloomington, IN 47405, USA
    J Am Chem Soc 128:13575-85. 2006
    ..Ar = 2,6-(CHMe2)(2C6H3, Trip = 2,4,6-(i)Pr3C6H2) was prepared by the addition of the primary phosphide LiPH[Trip] to the nucleophilic alkylidene triflato complex ((tBu)nacnac)Ti=CH(t)Bu(OTf), while alpha-H abstraction was ..
  20. pmc Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone
    Karen D Larbig
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
    J Bacteriol 184:6665-80. 2002
    ..aeruginosa chromosome. The ca. 110-kb large hypervariable region located near the lipH gene in two members of the predominant P. aeruginosa clone C, strain C and strain SG17M, was sequenced...
  21. ncbi Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features
    Toshiro Seki
    Division of General Internal Medicine, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Tokai J Exp Clin Med 37:126-32. 2012
    ..LAH), lymphocytic infundibulo-neurohypophysitis (LINH), and lymphocytic infundibulo-panhypophysitis (LIPH) according to the affected area...
  22. doi Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood
    K Tanahashi
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    J Eur Acad Dermatol Venereol 27:1182-4. 2013
    Mutations in LIPH are a cause of autosomal recessive woolly hair (ARWH). Homozygous c.736T>A (p.Cys246Ser), and compound heterozygous c.736T>A and c.742C>A (p...
  23. doi Mutations in LPAR6/P2RY5 and LIPH are associated with woolly hair and/or hypotrichosis
    M Kurban
    Department of Dermatology, Columbia University, New York, USA
    J Eur Acad Dermatol Venereol 27:545-9. 2013
    ..We have recently identified mutations in both LPAR6/P2RY5 and LIPH that are associated with autosomal recessive woolly hair (ARWH).
  24. pmc The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation
    Shaan L Gellatly
    Department of Microbiology and Immunology and Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 80:3122-31. 2012
    ..mutant cocultured on epithelial cells produced less secreted protease and lipase and, like the phoQ mutant, piv, lipH, and lasB mutants demonstrated reduced cytotoxicity toward epithelial cells...
  25. pmc A novel mutation in the Lipase H gene underlies autosomal recessive hypotrichosis and woolly hair
    Muhammad Tariq
    Human Molecular Genetics Laboratory, National Institute for Biotechnology and Genetic Engineering NIBGE, Faisalabad, Pakistan
    Sci Rep 2:730. 2012
    Mutations in the lipase member H (LIPH) gene cause autosomal recessive hypotrichosis with woolly hair. We report herein on five consanguineous families from Pakistan segregating hypotrichosis and woolly hair...
  26. pmc Surface loops of extracellular phospholipase A(1) determine both substrate specificity and preference for lysophospholipids
    Naoaki Arima
    Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, 980 8578 Japan
    J Lipid Res 53:513-21. 2012
    ..PS)-specific PLA(1) (PS-PLA(1)) and phosphatidic acid (PA)-selective PLA(1)α (PA-PLA(1)α, also known as LIPH) specifically hydrolyze PS and PA, respectively...
  27. doi Synthesis of 2-monoacylglycerols and structured triacylglycerols rich in polyunsaturated fatty acids by enzyme catalyzed reactions
    Alicia Rodriguez
    Department of Chemical Engineering, University of Almeria, 04120 Almeria, Spain
    Enzyme Microb Technol 51:148-55. 2012
    ..up by multiplying the reactant amounts 100-fold and maintaining the intensity of treatment constant (IOT=3g lipase h/g oil). In these conditions, the 2-MAG yield attained was about 67%; these 2-MAGs contained 36.6% DHA...
  28. ncbi Identification of an Alu-mediated 12.2-kb deletion of the complete LPAR6 (P2RY5) gene in a Turkish family with hypotrichosis and woolly hair
    Hassnaa Mahmoudi
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Exp Dermatol 21:469-71. 2012
    ..Disease-causing mutations in LIPH, LPAR6 and KRT74 have recently been identified...
  29. pmc LIPH expression in skin and hair follicles of normal coat and Rex rabbits
    Mathieu Diribarne
    INRA, UMR1313, Unité de Génétique Animale et Biologie Intégrative, Jouy en Josas, France
    PLoS ONE 7:e30073. 2012
    Natural mutations in the LIPH gene were shown to be responsible for hair growth defects in humans and for the rex short hair phenotype in rabbits...
  30. doi A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis
    Atsushi Fujimoto
    Laboratory of Genetic Skin Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Invest Dermatol 132:2342-9. 2012
    ..ARWH has recently been shown to be caused by mutations in either the lysophosphatidic acid receptor 6 (LPAR6) or lipase H (LIPH) gene. More recently, a mutation in the keratin K74 (KRT74) gene has been reported to underlie ADWH...
  31. doi A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp
    S Nahum
    Center for Translational Genetics, Rappaport Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Clin Exp Dermatol 36:188-94. 2011
    ..In a small number of families, the condition has been associated with mutations in three distinct genes: DSG4, LIPH and LPAR6.
  32. ncbi A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid
    Hirofumi Sonoda
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:34254-63. 2002
    ..These data show that the enzyme is a membrane-associated PA-selective PLA(1) and suggest that it has a role in LPA production...
  33. pmc A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Oryctolagus cuniculus)
    Mathieu Diribarne
    INRA, UMR1313, Unité de Génétique Animale et Biologie Intégrative, INRA, Jouy en Josas, France
    PLoS ONE 6:e19281. 2011
    ..Comparative mapping pointed out a candidate gene in this 700 kb region, namely LIPH (Lipase Member H). In humans, several mutations in this major gene cause alopecia, hair loss phenotypes...
  34. ncbi Molecular genetics of the extracellular lipase of Pseudomonas aeruginosa PAO1
    S Wohlfarth
    Ruhr Universitat Bochum, Lehrstuhl für Biologie der Mikroorganismen, Bochum, FRG
    J Gen Microbiol 138:1325-35. 1992
    ..Located 220 bp downstream of the lipA gene, is an open reading frame (ORF2, lipH) which encodes a hydrophilic protein (283 amino acids; M(r) 33587) that shows some homology to the limA gene ..
  35. doi Identification of 736T>A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair
    Takashi Yoshimasu
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 38:900-4. 2011
    Woolly hair is characterized by fine and tightly curled hair. It has recently been revealed that both LPAR6 and lipase H (LIPH) mutations cause autosomal recessive woolly hair (ARWH)/hypotrichosis...
  36. ncbi Identification of LIPH gene mutation in a consanguineous family segregating the woolly hair/hypotrichosis phenotype
    Sayed Hajan Shah
    Centre for Human Genetics and Molecular Medicine, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    J Pak Med Assoc 61:1060-4. 2011
    ..To identify the disease causing gene in a four generation consanguineous family in which eleven family members were suffering from Woolly hair/hypotrichosis phenotype...
  37. doi Sequence and expression of the chicken membrane-associated phospholipases A1 alpha (LIPH) and beta (LIPI)
    Manuela Hesse
    Department of Pediatrics, Children s Cancer Research Centre, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06097, Halle, Germany
    Mol Biol Rep 39:761-9. 2012
    ..The high homology of LIPI and the membrane-associated phospholipase A1 alpha (lipase family member H, LIPH) suggests that both genes are derived from a common ancestor by gene duplication...
  38. doi Congenital hair loss disorders: rare, but not too rare
    Yutaka Shimomura
    Laboratory of Genetic Skin Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Dermatol 39:3-10. 2012
    ..populations, most patients with congenital woolly hair/hypotrichosis possess common founder mutations in the lipase H (LIPH) gene...
  39. doi A large duplication in LIPH underlies autosomal recessive hypotrichosis simplex in four Middle Eastern families
    Sagi Nahum
    Laboratory of Molecular Dermatology, Department of Dermatology, Rambam Medical Center, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel
    Arch Dermatol Res 301:391-3. 2009
    ..microsatellite markers spanning all ARHS-associated loci and obtained data suggesting linkage to 3q27, encompassing LIPH, which had previously been shown to be associated with ARHS...
  40. doi Novel mutations in the P2RY5 gene in one Turkish and two Indian patients presenting with hypotrichosis and woolly hair
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, 53111 Bonn, Germany
    Arch Dermatol Res 301:621-4. 2009
    ..We and others have previously reported mutations in the P2RY5 gene and the LIPH gene as being causal factors of autosomal recessive hypotrichosis simplex with or without woolly hair...
  41. ncbi Phosphinidene complexes of scandium: powerful par group-transfer vehicles to organic and inorganic substrates
    Benjamin F Wicker
    Department of Chemistry and Molecular Structure Center, Indiana University, Bloomington, Indiana 47405
    J Am Chem Soc 132:3691-3. 2010
    ..When complex (PNP)Sc(CH(3))Br (1) is treated with 1 equiv of LiPH[Trip] (Trip = 2,4,6-(i)Pr(3)C(6)H(2)), the dinuclear scandium phosphinidene complex [(PNP)Sc(mu(2)-P[Trip])](2) (2) ..
  42. pmc The effect of inbreeding on the distribution of compound heterozygotes: a lesson from Lipase H mutations in autosomal recessive woolly hair/hypotrichosis
    Lynn Petukhova
    Department of Dermatology, School of Public Health, Columbia University, New York, N Y 10032, USA
    Hum Hered 68:117-30. 2009
    ..two genes that underlie autosomal recessive woolly hair (ARWH/hypotrichosis; OMIM278150), specifically P2RY5 and Lipase H (LIPH)...
  43. ncbi Mechanisms of lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Semin Cell Dev Biol 15:477-89. 2004
    ..However, apparently certain extracellular phospholipases such as secretory PLA2 (sPLA2-IIA), membrane-associated PA-selective PLA1 (mPA-PLA1), lecithin-cholesterol acyltransferase (LCAT), and lysoPLD are involved in LPA production...
  44. ncbi The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus
    G De Simone
    Centro di Studio di Biocristallografia CNR, University of Naples Federico II, Via Mezzocannone 6 8, Naples, 80134, Italy
    J Mol Biol 314:507-18. 2001
    ..The variety of structural differences suggests possible strategies for thermostabilization of lipases and esterases with potential industrial applications...
  45. doi Tissue distribution of lipase genes related to triglyceride metabolism in laying hens (Gallus gallus)
    Kan Sato
    Animal Science, Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu shi, Tokyo, 183 8509, Japan
    Comp Biochem Physiol B Biochem Mol Biol 155:62-6. 2010
    ..lipase (LPL), hepatic triglyceride lipase (HTGL), carboxyl ester lipase (CEL), endothelial lipase (EL), Lipase H, hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), plays a critical role in lipid metabolism ..
  46. ncbi Relationship between post-heparin plasma lipases, triglycerides and high density lipoproteins in normal subjects
    R L Jackson
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio
    Horm Metab Res 22:289-94. 1990
    ..These results in normal subjects provide further evidence that LpL and H-TGL are important enzymes in the metabolism of plasma lipoproteins and that changes in their activities contribute to plasma lipid and lipoprotein concentrations...
  47. ncbi Lipase H, a new member of the triglyceride lipase family synthesized by the intestine
    Weijun Jin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genomics 80:268-73. 2002
    ..4-kb cDNA encoding human lipase H (LIPH) and the mouse ortholog (Liph). The human LIPH cDNA encodes a 451-amino-acid protein with a lipase domain...
  48. ncbi Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans
    Xiao Yan Wen
    Department of Experimental Therapeutics, Toronto General Research Institute, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Hum Mol Genet 12:1131-43. 2003
    ..Using bioinformatics, we identified another novel lipase designated LPDLR (for 'LPDL related lipase'), which had 44% protein sequence identity with LPDL...
  49. ncbi Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta
    Tatsufumi Hiramatsu
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:49438-47. 2003
    ..The present study raises the possibility that production of LPA by mPA-PLA1alpha and -beta occurs on detergent-resistant membrane domains of the cells where they compete with lipid phosphate phosphatase for PA...
  50. ncbi Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH
    Anastasiya Kazantseva
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Science 314:982-5. 2006
    ..The LIPH gene is expressed in hair follicles and encodes a phospholipase called lipase H (alternatively known as membrane-associated phosphatidic acid-selective phospholipase A1alpha), an enzyme that ..
  51. ncbi Characterization and purification of acidocin 1B, a bacteriocin produced by Lactobacillus acidophilus GP1B
    Kyoung Sik Han
    Riddet Centre, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    J Microbiol Biotechnol 17:774-83. 2007
    ..65 Da by mass spectrometry. Plasmid curing results indicated that a plasmid, designated as pLA1B, seemed to be responsible for both acidocin 1B production and host immunity, and that the pLA1B could be ..
  52. ncbi Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase
    G A Martin
    Merrell Dow Research Institute, Cincinnati, Ohio 45215
    J Biol Chem 263:10907-14. 1988
    ..The carboxyl terminus of H-TGL contains a highly basic sequence which is not reported to be present in rat H-TGL or other members of the lipase gene family...
  53. doi In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn D 53111, Germany
    J Invest Dermatol 129:2772-6. 2009
    ..Mutations in LIPH, which encodes lipase member H, have recently been shown to cause an autosomal-recessive form of HS...
  54. pmc Founder mutations in the lipase h gene in families with autosomal recessive woolly hair/hypotrichosis
    Yutaka Shimomura
    Department of Dermatology, Columbia University, New York, New York, USA
    J Invest Dermatol 129:1927-34. 2009
    ..ARWH can be caused by mutations in the P2RY5 or lipase H (LIPH) gene...
  55. ncbi Mutations in lipase H cause autosomal recessive hypotrichosis simplex with woolly hair
    Liran Horev
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Am Acad Dermatol 61:813-8. 2009
    Mutations in lipase H (LIPH) are a rare cause of autosomal recessive hypotrichosis (HT) simplex.
  56. ncbi Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2)
    Gul Naz
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    J Dermatol Sci 54:12-6. 2009
    ..However, affected male individuals have normal beard hair. Mutations in lipase H (LIPH) gene, located on chromosome 3q26.33, have been shown to be responsible for LAH2 type of hypotrichosis.
  57. doi Woolly antics between the sheaths
    Desmond J Tobin
    Center for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, West Yorkshire, UK
    J Invest Dermatol 129:540-2. 2009
    ..In this issue, Shimomura et al. present some intriguing insights into the potential role for lipase H in the control of hair form and texture.
  58. ncbi Two pathways for lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aobayama, Aoba ku, Sendai, 980 8578, Japan
    Biochim Biophys Acta 1781:513-8. 2008
    ..One PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a ..
  59. ncbi Overexpression, immobilization and biotechnological application of Pseudomonas lipases
    M T Reetz
    Max Planck Institut fur Kohlenforschung, Mulheim, Ruhr, Germany
    Chem Phys Lipids 93:3-14. 1998
    ..Controllable expression of the gene lipH encoding a lipase-specific foldase proves to be important for overexpression in the homologous host Escherichia ..
  60. ncbi Functional cell-surface display of a lipase-specific chaperone
    Susanne Wilhelm
    Institute of Molecular Enzyme Technology, Heinrich Heine University Dusseldorf, Research Centre Julich, 52426 Julich, Germany
    Chembiochem 8:55-60. 2007
    ..The model Lif protein, LipH from P. aeruginosa, was displayed at the surface of E. coli cells...
  61. doi Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa
    Frank Rosenau
    Institute for Molecular Enzyme Technology, Research Centre Juelich, Heinrich Heine University Duesseldorf, Juelich, Germany
    FEMS Microbiol Lett 309:25-34. 2010
    ..LipA is encoded within the lipA/lipH operon, together with its cognate foldase LipH, which was also found to be required for the functional expression ..

Research Grants4

  1. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2004
    The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  2. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2005
    The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  3. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  4. RADIOIMMUNOASSAY OF HUMAN POSTHEPARIN PLASMA LIPASES
    Virgil Brown; Fiscal Year: 1980
    ..Primary cultures of monkey liver cells will be attempted to provide a system for study of H-TGL synthesis and secretion using the radioimmunoassay developed above...