LIPG

Summary

Gene Symbol: LIPG
Description: lipase, endothelial
Alias: EDL, PRO719, endothelial cell-derived lipase, endothelial lipase, lipoprotein lipase H
Species: human

Top Publications

  1. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
  2. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
  3. pmc Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
  4. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
  5. doi Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
  6. ncbi Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies
    M Gauster
    Institute of Histology, Cell Biology, and Embryology, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, Graz, Austria
    J Clin Endocrinol Metab 92:2256-63. 2007
  7. ncbi Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    Na Ping Tang
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
    J Lipid Res 49:369-75. 2008
  8. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
  9. ncbi Endothelial lipase is associated with inflammation in humans
    Marie Eve Paradis
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
    J Lipid Res 47:2808-13. 2006
  10. ncbi Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
    Masakatsu Shimizu
    Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ J 71:842-6. 2007

Research Grants

Detail Information

Publications170 found, 100 shown here

  1. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Animal models indicate that decreased expression of endothelial lipase (LIPG) is inversely associated with HDL-C levels, and genome-wide association studies have identified LIPG ..
  2. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
    ..Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease...
  3. pmc Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
    ..haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL), consistent with its role in HDL-C catabolism...
  4. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    High-density lipoprotein (HDL) protects against atherosclerosis. Endothelial lipase (EL) has been postulated to be involved in lipoprotein, and possibly HDL, metabolism, yet the evidence has been scarce and conflicting...
  5. doi Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  6. ncbi Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies
    M Gauster
    Institute of Histology, Cell Biology, and Embryology, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, Graz, Austria
    J Clin Endocrinol Metab 92:2256-63. 2007
    ..Fetal supply of maternally derived fatty acids requires lipase-mediated hydrolysis of lipoprotein-borne triglycerides and phospholipids at the placental surface...
  7. ncbi Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    Na Ping Tang
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
    J Lipid Res 49:369-75. 2008
    The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) ..
  8. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism...
  9. ncbi Endothelial lipase is associated with inflammation in humans
    Marie Eve Paradis
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
    J Lipid Res 47:2808-13. 2006
    The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men...
  10. ncbi Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
    Masakatsu Shimizu
    Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ J 71:842-6. 2007
    b>Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment...
  11. pmc Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, United States
    Atherosclerosis 206:500-4. 2009
    ..HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG).
  12. pmc Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation
    Nathalie Griffon
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:23322-30. 2009
    b>Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase...
  13. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
    ..other family members, this new lipase is synthesized by endothelial cells in vitro and thus has been termed endothelial lipase (encoded by the LIPG gene)...
  14. doi Role of endothelial lipase in atherosclerosis
    Ji Huang
    Emergency Center of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital University of Medical Sciences and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, P R China
    Transl Res 156:1-6. 2010
    b>Endothelial lipase, which is a newly identified member of the lipase family, plays an important role in high-density lipoprotein metabolism, which catalyzes the hydrolysis of high-density lipoprotein phospholipids and facilitates the ..
  15. ncbi Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
    Cyrille Maugeais
    Departments of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 108:2121-6. 2003
    ..Overexpression of endothelial lipase (EL) markedly reduces plasma levels of HDL cholesterol and apoA-I in mice, but the mechanisms of this effect ..
  16. ncbi The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, Pavillon Paul Comtois, Office 2423, Laval University, Quebec G1K 7P4, Canada
    J Lipid Res 44:1902-8. 2003
    The objective of the present study was to examine the impact of the T111I missense mutation in exon 3 of the endothelial lipase (EL) gene on HDL and its potential interaction effect with dietary fat...
  17. ncbi Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
    The LIPG gene on chromosome 18 encodes for endothelial lipase, a member of the triglyceride lipase family...
  18. pmc Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
    Endothelial cell-derived lipase (EDL) is a new member of the lipase gene family with high sequence homology with lipoprotein lipase (LPL). EDL is a phospholipase with very little triacylglycerol lipase activity...
  19. ncbi Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 47:2581-8. 2006
    ..The placental triglyceride (TG) concentration and mRNA expression of endothelial lipase (EL) and hormone-sensitive lipase (HSL) were increased in placentas from women with diabetes...
  20. ncbi Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation
    Yoko Kojma
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:54032-8. 2004
    b>Endothelial lipase (EL), a new member of the lipoprotein lipase gene family, plays a central role in high density lipoprotein metabolism...
  21. doi Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells
    Annukka M Kivelä
    The Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, Neulaniementie 2, FIN 70211 Kuopio, Finland
    Atherosclerosis 213:122-8. 2010
    b>Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis...
  22. ncbi Characterization of the lipolytic activity of endothelial lipase
    Mary G McCoy
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 43:921-9. 2002
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity...
  23. doi Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase
    Niels Nijstad
    Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 284:6093-100. 2009
    b>Endothelial lipase (EL) is a negative regulator of high density lipoprotein (HDL) cholesterol plasma levels, and scavenger receptor BI (SR-BI) is involved in remodeling of HDL...
  24. ncbi Insulin resistance and hypertension: in vivo and in vitro insulin action in skeletal muscle in spontaneously hypertensive and Wistar-Kyoto rats
    A L Swislocki
    Medical Service, Department of Veterans Affairs Northern California Health Care System, Martinez 94533, USA
    Am J Hypertens 10:1159-64. 1997
    ..increased from 377 +/- 120 to 439 +/- 175 disintegrations per minute (dpm) 3H-glucose/mg extensor digitorum longus (EDL) in WKY when insulin increased from 0 to 1000 microU/mL (P < ...
  25. pmc Acute effects of the beta 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilisation
    Y L Liu
    Department of Physiology, St George s Hospital Medical School, Tooting, London
    Br J Pharmacol 114:888-94. 1995
    ..and potentiated the response in Type II (non-working) muscles such as tibialis and extensor digitorium longus (EDL). 4...
  26. ncbi Dissociation between insulin binding and glucose utilization after intense exercise in mouse skeletal muscles
    A Bonen
    Department of Physiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Horm Metab Res 21:172-8. 1989
    ..2-deoxy-d-glucose (2-DOG) uptake and glucose incorporation into glycogen and glycolysis were compared in soleus and EDL muscles of intensively exercised (2-3 h) mice and non-exercised mice...
  27. pmc Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase
    Luis Da Silva-Azevedo
    Department of Physiology, Charite Campus Benjamin Franklin, Arnimallee 22, Berlin Dahlem, Germany
    J Physiol 587:655-68. 2009
    ..subsequent tandem mass spectrometry (LC-MS/MS) was performed using extracts of extensor digitorum longus muscle (EDL) derived from nNOS-knockout mice in comparison to C57Bl/6 control mice...
  28. ncbi Skeletal muscle myosin heavy chain expression in rats with monocrotaline-induced cardiac hypertrophy and failure. Relation to blood flow and degree of muscle atrophy
    G Vescovo
    First Division of Internal Medicine, Venice City Hospital, Italy
    Cardiovasc Res 39:233-41. 1998
    ..In congestive heart failure (CHF) the skeletal muscle of the lower limbs develops a myopathy characterised by atrophy and shift from the slow to the fast type fibres. The mechanisms responsible for these changes are not clear yet...
  29. pmc Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation
    M C Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Physiol Regul Integr Comp Physiol 298:R2-8. 2010
    ..Intact extensor digitorum longus (EDL) and soleus muscles from mice were also incubated in vitro with oxypurinol or polyethylene glycol-tagged Cu,Zn-SOD...
  30. pmc Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 139:291-304. 2011
    b>Endothelial lipase (gene: LIPG; enzyme: EL) is one of three members of the triglyceride lipase family that contributes to lipoprotein degradation within the circulation system and plays a major role in HDL metabolism in the body...
  31. ncbi Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway
    Ilia V Fuki
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:34331-8. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family, which includes lipoprotein lipase (LpL) and hepatic lipase (HL). Enzymatic activity of EL has been studied before...
  32. ncbi Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins
    Daniela Caiazza
    Lipid Research Group, The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia
    Biochemistry 43:11898-905. 2004
    b>Endothelial lipase (EL) is a newly identified member of the triglyceride lipase gene family that hydrolyzes high-density lipoprotein (HDL) phospholipids...
  33. ncbi In vitro 1H-NMR spectroscopic analysis of metabolites in fast- and slow-twitch muscles of young rats
    Yoshichika Yoshioka
    Department of Physiology II, School of Medicine, Iwate Medical University, Morioka, Japan
    Magn Reson Med Sci 1:7-13. 2002
    ..TAU), anserine (ANS) and carnosine (CAR) content of the masseter muscles (MM), long extensor muscles of digits (EDL) and soleus muscles (SOL) of young rats were determined using in vitro 1H-NMR spectroscopy to assess the ..
  34. pmc Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    b>Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models...
  35. ncbi Differences in glucose transport rates between perfused and in vitro incubated muscles
    M Kern
    Department of Biochemistry, East Carolina University, School of Medicine, Greenville, North Carolina
    Horm Metab Res 22:366-8. 1990
    ..3-O-Methylglucose transport rates in incubated soleus (SOL) and extensor digitorum longus (EDL) muscle strips were compared to transport rates obtained in SOL and EDL muscles removed from perfused hindquarters...
  36. ncbi Electrostatic and electrochemical nature of liquid-gated electric-double-layer transistors based on oxide semiconductors
    Hongtao Yuan
    Quantum Phase Electronics Center and Department of Applied Physics, The University of Tokyo, Tokyo 113 8656, Japan, Japan Science and Technology Agency CREST, Kawaguchi 332 0012, Japan, Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan, and WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan
    J Am Chem Soc 132:18402-7. 2010
    The electric-double-layer (EDL) formed at liquid/solid interfaces provides a broad and interdisciplinary attraction in terms of electrochemistry, photochemistry, catalysts, energy storage, and electronics because of the large interfacial ..
  37. ncbi Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model
    Nobukazu Takahashi
    Division of Diagnostic Imaging, Box 57, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Acad Radiol 14:1050-7. 2007
    ..We previously have reported that (99m)Tc-labeled glutamate peptide-estradiol ((99m)Tc-GAP-EDL) is a useful agent for imaging functional estrogen receptor (ER) via an ER-mediated process...
  38. pmc Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat
    Robyn M Murphy
    Department of Zoology, La Trobe University, Melbourne, Victoria, Australia
    J Physiol 587:443-60. 2009
    ..the absolute amount of CSQ isoform 1 (CSQ1, the primary isoform) present in rat extensor digitorum longus (EDL) and soleus fibres, and related this to their endogenous and maximal SR Ca2+ content...
  39. ncbi Acute effects of N-acetylcysteine on skeletal muscle microcirculation following closed soft tissue trauma in rats
    Klaus D Schaser
    Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Orthop Res 23:231-41. 2005
    ..Microcirculation of the extensor digitorum longus (EDL) muscle was analyzed using intravital microscopy and Laser-Doppler flowmetry (LDF)...
  40. ncbi Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse
    Tatiana L Radzyukevich
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 287:C1445-52. 2004
    ..After 14-day simultaneous denervation of the soleus (Sol), tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius (Gastr) muscles by sciatic nerve section, DHPR mRNA increased preferentially in the Sol and TA (..
  41. doi Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors
    Tu Nguyen-Huu
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité Propre de Recherche 9040, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Anesthesiology 110:1011-5. 2009
    ..The basis of this difference may be a higher concentration of acetylcholine released or higher number of postsynaptic nicotinic acetylcholine receptors in diaphragmatic neuromuscular junctions...
  42. ncbi Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis
    Claire Thomas
    Universite Montpellier 1, UFR Médecine EA701, F 34295, Montpellier, France
    Am J Physiol Endocrinol Metab 293:E916-22. 2007
    ..MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles...
  43. ncbi Myofascial force transmission causes interaction between adjacent muscles and connective tissue: effects of blunt dissection and compartmental fasciotomy on length force characteristics of rat extensor digitorum longus muscle
    P A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Physiol Biochem 109:97-109. 2001
    Muscles within the anterior tibial compartment (extensor digitorum longus: EDL, tibialis anterior: TA, and extensor hallucis longus muscles: EHL) and within the peroneal compartment were excited simultaneously and maximally...
  44. pmc Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism
    Gentian Lluri
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Neurobiol 66:1365-77. 2006
    ..report that TIMP-2 is expressed at the NMJ and its expression is greater in fast-twitch (extensor digitorum longus, EDL) than slow-twitch (soleus) muscle...
  45. doi Myofascial force transmission via extramuscular pathways occurs between antagonistic muscles
    Peter A Huijing
    Research Instituut Move, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Cells Tissues Organs 188:400-14. 2008
    ..force was measured simultaneously at: (1) the proximal and distal tendons of the extensor digitorum muscle (EDL) to quantify any proximo-distal force differences, as an indicator of myofascial force transmission, (2) at the ..
  46. ncbi Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation
    Blake C Beehler
    Cardiovascular and Metabolic Diseases Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08543, USA
    Exp Biol Med (Maywood) 231:335-41. 2006
    ..At the end of the study, the rats were euthanized and the soleus and extensor digitorum longus (EDL) muscles were harvested. In vehicle-treated rats, denervation caused a 33.5 +/- 2.8% and 16.2 +/- 2...
  47. pmc Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels
    A De Luca
    Dipartimento Farmacobiologico, Facolta di Farmacia, Universita di Bari, Italy
    Br J Pharmacol 125:477-82. 1998
    ..2. For this purpose G(Cl) in EDL muscle isolated from adult rat was first lowered by treatment with 5 nM 4-beta-phorbol 12,13 dibutyrate (4-beta-PDB)..
  48. ncbi Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration
    Oliver Baum
    Department of Anatomy and Physiology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Königin Luise Str 15, D 14195 Berlin Dahlem, Germany
    Am J Physiol Heart Circ Physiol 287:H2300-8. 2004
    ..of capillaries/mm2) were determined in frozen sections from extensor digitorum longus (EDL) muscles of these mice...
  49. pmc Protein diffusion in living skeletal muscle fibers: dependence on protein size, fiber type, and contraction
    S Papadopoulos
    Department of Physiology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Biophys J 79:2084-94. 2000
    ..were injected into single, intact skeletal muscle fibers taken from either soleus or extensor digitorum longus (edl) muscle of adult rats...
  50. pmc Acute molecular response of mouse hindlimb muscles to chronic stimulation
    W A Laframboise
    Dept of Pathology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Shadyside Hospital West Wing, WG02 11, 5230 Center Ave, Pittsburgh, PA 15232, USA
    Am J Physiol Cell Physiol 297:C556-70. 2009
    ..An immediate-early growth response was present in the extensor digitorum longus (EDL) muscle (FOS, JUN, activating transcription factor 3, and musculoaponeurotic fibrosarcoma oncogene) with a similar ..
  51. ncbi Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles
    F Yu
    Noll Physiological Research Center and Department of Cellular and Molecular Physiology, Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    Am J Physiol Regul Integr Comp Physiol 278:R1545-54. 2000
    ..In fast-twitch extensor digitorum longus (EDL) muscle, TR-alpha(1)-, TR-beta-, or TR-alpha(1)beta-deficient mice showed a small but statistically significant ..
  52. ncbi 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora
    Yongping Cao
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Kita gun Kagawa 761 0793, Japan
    Bone 40:132-9. 2007
    ....
  53. ncbi Vinculin and meta-vinculin in fast and slow rat skeletal muscle before and after hindlimb suspension
    Angèle Chopard
    Laboratoire de Physiologie Cellulaire et Moléculaire Des Systèmes Intégrés, CNRS, Unité Mixte de Recherche 6548, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Pflugers Arch 444:627-33. 2002
    ..the expression of these proteins in a slow-twitch (soleus) and in a fast-twitch (extensor digitorum longus, EDL) skeletal muscle under control conditions and after a reduced functional demand...
  54. ncbi Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres
    Petra Wetzel
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany, Wetzel
    Pflugers Arch 443:762-70. 2002
    Muscle carbonic anhydrase (CA) was inhibited in fibre bundles of the extensor digitorum longus (EDL) and soleus (SOL) muscles from rats. Isometric single twitches were recorded in the absence or presence of the CA inhibitors...
  55. doi Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle
    Milan Holecek
    Department of Physiology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    Amino Acids 40:575-84. 2011
    ..M. soleus (SOL, slow-twitch, red muscle) and m. extensor digitorum longus (EDL, fast-twitch, white muscle) of white rat were isolated and incubated in a medium with or without 500 μM ammonia...
  56. ncbi A comparison of the electrophysiological effects of two organophosphates, mipafox and ecothiopate, on mouse limb muscles
    G E de Blaquière
    Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, United Kingdom
    Toxicol Appl Pharmacol 150:350-60. 1998
    ..Acetylcholinesterase activity was measured in the soleus (slow-twitch) and extensor digitorum longus (EDL; fast-twitch) muscles...
  57. ncbi Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I
    A Jahangiri
    Lipid Research Group, Heart Research Institute, Camperdown, Sydney, New South Wales 2050, Australia
    J Lipid Res 46:896-903. 2005
    b>Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity...
  58. ncbi Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
    ..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
  59. ncbi Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
    ..The sedentary control animals remained in their cages. For each animal, Po was determined in the fast-twitch EDL and slow-twitch soleus muscles from one hindlimb and quantitative measurements of [Ca2+]i were made in the ..
  60. ncbi Contractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II
    Matthew D Beekley
    Zentrum Physiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Pflugers Arch 452:453-63. 2006
    ..Because of this, we compared the in vitro contractile properties of extensor digitorum longus (EDL) and soleus (SOL) fibre bundles from mice deficient in CA II (CAD) to litter mate controls (LM)...
  61. pmc Tetanus relaxation of fast skeletal muscles of the mouse made parvalbumin deficient by gene inactivation
    J M Raymackers
    Departement de Physiologie, Universite Catholique de Louvain, B 1200 Bruxelles, Belgium
    J Physiol 527:355-64. 2000
    The effects of tetanus duration on the relaxation rate of extensor digitorum longus (EDL) and flexor digitorum brevis (FDB) muscles were studied in normal (wild-type, WT) and parvalbumin-deficient (PVKO) mice, at 20 C...
  62. ncbi The relationship between skeletal muscle proteolysis and ubiquitin-proteasome proteolytic pathway in burned rats
    Jiake Chai
    Department of Burns and Plastic Surgery, Burns Institute, 304th Hospital, Beijing 100037, China
    Burns 28:527-33. 2002
    ..The proteolytic rates and mRNA expression of ubiquitin, E2-14K, and subunit RC2 in extensor digital longus (EDL) and soleus (SOL) muscle were determined by amino acid analyzer and Northern blot, respectively...
  63. ncbi Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage
    A Lionikas
    Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Genomics 16:141-52. 2003
    ..slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C57BL/6J (B6) than in DBA/2J (D2) mice...
  64. ncbi Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
    J Exp Biol 205:2337-48. 2002
    ..type IIA fibres in normal rat soleus (N-SOL) muscle and of the type IIA fibres in extensor digitorum longus (N-EDL) muscle...
  65. pmc Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice
    G J Etgen
    Pfizer Central Research, Eastern Point Road, Groton, CT 06340, USA
    Biochem J 337:51-7. 1999
    ..mannos-4-yloxy)-2-propylamine photolabelling methodology in both isolated and perfused extensor digitorum longus (EDL). Cell-surface GLUT1 was enhanced by as much as 70-fold in both isolated and perfused EDL of transgenic mice...
  66. ncbi Decreased monocarboxylate transporter 1 in rat soleus and EDL muscles exposed to clenbuterol
    T Kitaura
    Faculty of Pharmaceutical Sciences, University of Kanazawa, Kakuma, Kanazawa 920 1192, Japan
    J Appl Physiol (1985) 91:85-90. 2001
    ..LDH) and isoform pattern and shift myosin heavy chain (MHC) pattern in soleus (Sol) and extensor digitorum longus (EDL) of male rats. In the clenbuterol-administered rats (2...
  67. ncbi Post-effects of nandrolone decanoate treatment on contractile responses of rat skeletal muscles
    Wissam H Joumaa
    Laboratoire de Physiologie Generale, CNRS UMR 6018, Faculte des Sciences et des Techniques, Universite de Nantes, B P 92208, 44322 Nantes, France
    Jpn J Physiol 52:479-87. 2002
    ..on contractile responses of isolated small bundles of intact slow-(soleus) and fast-(extensor digitorum longus, edl) twitch fibers in rat...
  68. doi Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
    J G Kemp
    1 School of Biomedical and Health Sciences, Victoria University, Footscray, Victoria, Australia
    Int J Obes (Lond) 33:831-41. 2009
    ..Knowledge of the morphological and biochemical alterations occurring in skeletal muscles of obese animals is relatively limited, particularly with respect to non-limb muscles and relationship to fibre type...
  69. ncbi Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles
    Cyril Bozzo
    Department of Anatomy and Physiology, University of Padova, Italy
    FEBS J 272:5771-85. 2005
    ..chains (MLC1) and regulatory myosin light chains (MLC2) in rat slow (soleus) and fast (extensor digitorum longus EDL) muscles using 2D-gel electrophoresis and mass spectrometry...
  70. doi Treating retinoblastoma in tissue culture and in a rat model with a novel isoquinoline derivative
    Mohamed Nassr
    Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Invest Ophthalmol Vis Sci 51:3813-9. 2010
    PURPOSE. To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblastoma in vitro and in vivo. METHODS...
  71. ncbi The role of ascorbic acid and exercise in chronic ischemia of skeletal muscle in rats
    T Loizidis
    Laboratory of Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Appl Physiol 102:321-30. 2007
    ..on muscle performance, cross-sectional area, and ultrastructural morphology in extensor digitorum longus (EDL) and soleus (Sol) muscles in rats...
  72. pmc Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice
    Benjamin T Corona
    Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, GA 30302 3975, USA
    J Appl Physiol (1985) 105:1542-53. 2008
    ..RYR1Y522S/wt) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (EDL) muscles] damage and strength deficits following the performance of a single or repeated bouts of eccentric ..
  73. ncbi Myosin heavy chain expression in skeletal muscle autografts under neural or aneural conditions
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Surg Res 75:135-47. 1998
    ....
  74. pmc Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    Iulia Iatan
    Department of Biochemistry, Cardiovascular Research Laboratories, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 2:467-75. 2009
    ..HDL particles are modulated by a variety of lipases, including endothelial lipase, a phospholipase present on vascular endothelial cells...
  75. ncbi Mitochondrial superoxide production in skeletal muscle fibers of the rat and decreased fiber excitability
    Chris van der Poel
    Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Autralia
    Am J Physiol Cell Physiol 292:C1353-60. 2007
    ..responses were measured at 37 degrees C in mechanically skinned muscle fibers of rat extensor digitorum longus (EDL) muscle. In mechanically skinned fibers, the sarcolemma is removed avoiding potential sources of O(2)(...
  76. ncbi Role of load bearing in acetylcholinesterase regulation in rat skeletal muscles
    Peter Pregelj
    Institute of Pathophysiology, School of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Neurosci Res 67:114-21. 2002
    ..The levels of AChE mRNA in the slow soleus muscles are about 30% of those in the fast extensor digitorum longus (EDL) muscles...
  77. pmc Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
    J Clin Microbiol 41:4930-40. 2003
    The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into five "seropathotypes" (A through E) based on the reported ..
  78. ncbi Muscle fiber type composition and morphometric properties of denervated rat extensor digitorum longus muscle
    D Bobinac
    Department of Anatomy, Rijeka University School of Medicine, Brace Branchetta 22, 51000 Rijeka, Croatia
    Croat Med J 41:294-7. 2000
    Analysis of fiber type composition and fiber size of extensor digitorum longus (EDL) muscle in rats during 30 days of denervation.
  79. ncbi Effects of caffeine at different temperatures on contractile properties of slow-twitch and fast-twitch rat muscles
    Y Wondmikun
    Department of Physiology, University of Gondar, Ethiopia
    Physiol Res 55:641-52. 2006
    ..cold depression) in response to a decreased temperature, whereas the fast-twitch extensor digitorum longus (EDL) muscle shows enhanced twitch tension (cold potentiation)...
  80. ncbi Contraction and cation contents of skeletal soleus and EDL muscles in age-matched control and diabetic rats
    Apurva Chonkar
    Department of Biological Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE UK
    Ann N Y Acad Sci 1084:442-51. 2006
    ..investigates the effect of streptozotocin (STZ)-induced type 1 DM on contraction and cation contents in soleus and EDL muscles compared to age-matched control rats...
  81. pmc Cancer cachexia decreases specific force and accelerates fatigue in limb muscle
    B M Roberts
    1225 Center Drive, HPNP Building Room 1142, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
    Biochem Biophys Res Commun 435:488-92. 2013
    ..limb muscles during severe Colon-26 (C26) carcinoma cachexia by studying the glycolytic extensor digitorum longus (EDL) muscle and the oxidative soleus muscle, which has an activity pattern that more closely resembles the diaphragm...
  82. ncbi Structural basis of endothelial lipase tropism for HDL
    Uli C Broedl
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania, USA
    FASEB J 18:1891-3. 2004
    Lipoprotein lipase (LPL) and endothelial lipase (EL), the most closely related enzymes among the members of the triglyceride lipase gene family with regard to primary sequence, have distinct lipolytic properties (triglyceride lipase vs...
  83. pmc Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats
    Toru Taguchi
    Department of Neural Regulation, Division of Regulation of Organ Function, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    J Physiol 564:259-68. 2005
    ..of DOMS by inducing eccentric contraction (lengthening contraction, ECC) to the extensor digitorum longus muscle (EDL), and investigated the existence of mechanical hyperalgesia in the EDL by means of behavioural pain tests (Randall-..
  84. ncbi Increased cAMP as a positive inotropic factor for mammalian skeletal muscle in vitro
    S A Reading
    Department of Human Biology and Nutritional Sciences, University of Guelph, ON, Canada
    Can J Physiol Pharmacol 81:986-96. 2003
    ..concentration improves skeletal muscle force development, we stimulated mouse soleus and extensor digitorum longus (EDL) in the presence of isoproterenol (1 x 10(-5) mol...
  85. ncbi Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids
    MyNgan Duong
    Department of Medicine, University of Adelaide, North Terrace, Australia
    Biochemistry 42:13778-85. 2003
    Hepatic lipase (HL) and endothelial lipase (EL) are both members of the triglyceride lipase gene family. HL hydrolyzes phospholipids and triglycerides in triglyceride-rich lipoproteins and high-density lipoproteins (HDL)...
  86. ncbi Expression of the skeletal calsequestrin isoform in normal and regenerated skeletal muscles and in the hearts of rats with altered thyroid status
    T Soukup
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 61:575-86. 2012
    ..Muscle regeneration was achieved by intramuscular grafting of either soleus or extensor digitorum longus (EDL) from 3- to 4-week-old rats to either EDL or soleus muscle of 2-month-old rats...
  87. doi Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties
    Joan Carles Escola-Gil
    IIB Sant Pau 08025 Barcelona, Spain
    Biochim Biophys Acta 1831:691-7. 2013
    Hepatic lipase (HL) and endothelial lipase (EL) are negative regulators of plasma HDL cholesterol (HDLc) levels and presumably could affect two main HDL atheroprotective functions, macrophage-to-feces reverse cholesterol transport (RCT) ..
  88. pmc The effect of partial denervation of developing rats fast muscles on their motor unit properties
    F Tyc
    Department of Anatomy and Developmental Biology, Centre for Neuroscience, UCL, London, UK
    J Physiol 482:651-60. 1995
    1. The effects of partial denervation on motor units of the fast twitch extensor digitorum longus (EDL) muscle of the rat were studied. 2...
  89. pmc Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase
    Joanne M Wroblewski
    Department of Internal Medicine, Endocrinology Division and Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 52:2255-61. 2011
    Inflammation is associated with significant decreases in plasma HDL-cholesterol (HDL-C) and apoA-I levels. Endothelial lipase (EL) is known to be an important determinant of HDL-C in mice and in humans and is upregulated during ..
  90. ncbi The effect of a unilateral muscle transplantation on the muscle fiber type and the MyHC isoform content in unoperated hind limb slow and fast muscles of the inbred Lewis rats
    G ZACHAROVA
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 54:691-6. 2005
    ..the myosin heavy chain (MyHC) isoform expression in the rat slow soleus (SOL) and fast extensor digitorum longus (EDL) muscles, a method of heterochronous isotransplantation was developed...
  91. ncbi Mechanical power and myosin composition of soleus and extensor digitorum longus muscles of ky mice
    G Marechal
    Departement de Physiologie, Faculte de Medecine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol 268:C513-9. 1995
    ..Soleus and extensor digitorum longus (EDL) muscles from ky mice weighted < 50% of control muscles from age-matched NMRI mice...
  92. ncbi Myofascial force transmission: muscle relative position and length determine agonist and synergist muscle force
    Peter A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
    J Appl Physiol (1985) 94:1092-107. 2003
    Equal proximal and distal lengthening of rat extensor digitorum longus (EDL) were studied. Tibialis anterior, extensor hallucis longus, and EDL were active maximally. The connective tissues around these muscle bellies were left intact...
  93. ncbi Remodeling in the microcirculation of rat skeletal muscle during chronic ischemia
    M D Brown
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    Microcirculation 10:179-91. 2003
    ..To establish the time course and extent of remodeling of terminal microcirculation in ischemic rat skeletal muscle during prolonged low flow that does not lead to inflammation...
  94. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
    ....
  95. ncbi Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors
    Alfredo Morabia
    Division of Clinical Epidemiology, Geneva University Hospitals, Switzerland
    Hum Mol Genet 12:2733-43. 2003
    ..We propose a model involving these 14 genetic and non-genetic risk factors for evaluation in future independent studies...
  96. doi The effects of magnetic field on the biomechanics parameters of soleus and extensor digitorum longus muscles in rats with streptozotocin-induced diabetes
    A Pelit
    Biophysics Department, Cukurova University Medical Faculty, Adana, Turkey
    Diabetes Technol Ther 10:294-8. 2008
    The aim of this study was to determine the effects of the magnetic field (MF) on the isometric contractile characteristics of the soleus and extensor digitorum longus (EDL) muscles in rats both with and without diabetes.
  97. ncbi [The -384A >C polymorphism of endothelial lipase gene promoter region in Chinese healthy normolipidemic and endogenous hypertriglyceridemic subjects]
    Yi Huang
    West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041 People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:443-6. 2008
    To investigate the effects of the -384A>C polymorphism in the promoter region of endothelial lipase (EL) gene on serum lipid and apolipoprotein levels in healthy normolipidemic (HTG) and endogenous hypertriglyceridemic (HTG) subjects.
  98. doi Increase of the cytotoxic effect of Bothrops jararacussu venom on mouse extensor digitorum longus and soleus by potassium channel blockers and by Na(+)/K(+)-ATPase inhibition
    Marcelo A Tomaz
    Departamento de Farmacologia Basica e Clinica, ICB, CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
    Toxicon 52:551-8. 2008
    ..of Bothrops jararacussu crude venom and other cytolytic agents on mouse isolated extensor digitorum longus (EDL) and soleus (SOL) muscles, which present distinct properties: EDL is a fast-twitch, white muscle with predominantly ..
  99. pmc Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres
    R M Murphy
    Department of Zoology, La Trobe University, Melbourne 3086, Victoria, Australia
    J Physiol 586:2203-16. 2008
    ..Here, using skinned fibres from rat extensor digitorum longus (EDL) and soleus muscle, it is shown that although H(2)O(2) (> or = 100 microm) has little effect by itself, when ..
  100. pmc Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway
    Yasuki Higaki
    Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Am J Physiol Endocrinol Metab 294:E889-97. 2008
    ..Exposure of isolated rat extensor digitorum longus (EDL) muscles to Hx/XO (Hx/XO) for 20 min resulted in a dose-dependent increase in glucose uptake...
  101. doi Functional overloading of dystrophic mice enhances muscle-derived stem cell contribution to muscle contractile capacity
    Fabrisia Ambrosio
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Phys Med Rehabil 90:66-73. 2009
    ....

Research Grants67

  1. SKELETAL MUSCLE ENERGY METABOLISM
    Martin Kushmerick; Fiscal Year: 1993
    ..kinetics under homogenous in vitro conditions are different from those in isolated mouse extensor digitorum longus (EDL) and soleus (SOL) muscles by measuring the forward and reverse fluxes between PCr and gammaATP catalyzed by CK in ..
  2. High Density Lipoprotein Metabolism Influence of Extracellular Phospholipases
    Daniel Rader; Fiscal Year: 2007
    ..We cloned and characterized a new member of the lipase gene family that we termed endothelial lipase (EL)...
  3. Role of Endothelial Lipase in Atherosclerosis
    HAMID RAZZAGHI; Fiscal Year: 2007
    ..Recently, a newly discovered gene, called endothelial lipase (EL), has been shown to have several unique features that make EL a prime candidate gene for low HDL-C and ..
  4. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  5. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  6. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2010
    ..all enzymes that utilize PC as substrate will be tested with respect to secretory phospholipases and endothelial lipase. The inhibitory role of SM in the generation of pro-inflammatory oxidized PCs and oxysterols will be tested ..
  7. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006
    ..The focus of the research project is endothelial lipase (EL), a member of the triglyceride lipase family that has been shown, in mouse over expression studies, to ..
  8. The Role of Apolipoprotein A-II in the Modulation of HDL Function
    RANASINGHE SILVA; Fiscal Year: 2007
    ..HDL remodeling factors including lecithin:cholesterol acyl transferase (LCAT), hepatic lipase (HL), and endothelial lipase (EL)...
  9. Androgen targets in a simple behavioral system
    Cynthia Jordan; Fiscal Year: 2003
    ..the cells in rat muscles that express ARs, comparing the levator ani (LA) to the extensor digitorum longus (EDL), which differ in their sensitivity to androgens...
  10. E. coli O157:H7 genes induced during human infection
    INDIRA KUDVA; Fiscal Year: 2005
    ..The genes contained in reactive clones will be identified by BLAST, against the genomes of O157 EDL 933 and Sakai strains, and other DNA sequences available in the National Center for Biotechnology Information (NCBI)..
  11. SINGLE SKETETAL MUSCLE FIBER IMPAIRMENT WITH AGING
    Osvaldo Delbono; Fiscal Year: 2001
    ..with alterations in sarcoplasmic reticulum calcium release in single fast- twitch extensor digitorum longus (EDL) muscle fibers from young (8 months), middle age (18), and old (28) Fisher 344 Brown Norway F1 Hybrid rats (..
  12. EXERCISE, DENERVATION AND INSULIN RESISTANCE IN MUSCLE
    Paul Pilch; Fiscal Year: 2005
    ..the basis for the inhibition of insulin-stimulated glycogen synthesis in the denervated extensor digitorum longus (EDL) muscle and its restoration by incubation with AICAR...
  13. HDL METABOLISM:INFLUENCE OF EXTRACELLULAR PHOSPHOLIPASES
    Daniel Rader; Fiscal Year: 2003
    ..reported the isolation and characterization of a new member of the lipoprotein lipase gene family termed endothelial lipase (EL) that is made by endothelial cells and has primarily phospholipase activity...
  14. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2007
    ..This will be accomplished in two stages: (i) initially the weight of soleus, tibialis anterior (TA), EDL, gastrocnemius and biceps brachii (BB) muscles will be measured in congenic C57BL/6...
  15. Alcohol and Chronic Disease Among Vulnerable Populations
    Eric Rimm; Fiscal Year: 2007
    ..alcohol dehydrogenase-3, hepatic lipase, lipoprotein lipase, cholesteryl ester transport protein, and endothelial lipase. The well characterized large cohorts of women and men with stored blood samples provide an unparalleled ..
  16. MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
    Marcia Ontell; Fiscal Year: 2004
    ..By transplanting newborn Myf 5 null extensor digitorum longus (EDL) muscles into the bed of normal hosts (where these muscle regenerate and become innervated), we can compare these ..