LIPG

Summary

Gene Symbol: LIPG
Description: lipase, endothelial
Alias: EDL, PRO719, endothelial cell-derived lipase, endothelial lipase, lipoprotein lipase H
Species: human

Top Publications

  1. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
  2. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
  3. ncbi Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
    Cyrille Maugeais
    Departments of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 108:2121-6. 2003
  4. ncbi Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
  5. ncbi Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
  6. ncbi Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
  7. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
  8. ncbi The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, Pavillon Paul Comtois, Office 2423, Laval University, Quebec G1K 7P4, Canada
    J Lipid Res 44:1902-8. 2003
  9. ncbi Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    Na Ping Tang
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
    J Lipid Res 49:369-75. 2008
  10. ncbi Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002

Research Grants

  1. SKELETAL MUSCLE ENERGY METABOLISM
    Martin Kushmerick; Fiscal Year: 1993
  2. High Density Lipoprotein Metabolism Influence of Extracellular Phospholipases
    Daniel Rader; Fiscal Year: 2007
  3. Role of Endothelial Lipase in Atherosclerosis
    HAMID RAZZAGHI; Fiscal Year: 2007
  4. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
  5. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
  6. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2010
  7. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006
  8. The Role of Apolipoprotein A-II in the Modulation of HDL Function
    RANASINGHE SILVA; Fiscal Year: 2007
  9. Androgen targets in a simple behavioral system
    Cynthia Jordan; Fiscal Year: 2003
  10. E. coli O157:H7 genes induced during human infection
    INDIRA KUDVA; Fiscal Year: 2005

Detail Information

Publications158 found, 100 shown here

  1. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
    ..Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease...
  2. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
    ..other family members, this new lipase is synthesized by endothelial cells in vitro and thus has been termed endothelial lipase (encoded by the LIPG gene)...
  3. ncbi Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase
    Cyrille Maugeais
    Departments of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 108:2121-6. 2003
    ..Overexpression of endothelial lipase (EL) markedly reduces plasma levels of HDL cholesterol and apoA-I in mice, but the mechanisms of this effect ..
  4. ncbi Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Animal models indicate that decreased expression of endothelial lipase (LIPG) is inversely associated with HDL-C levels, and genome-wide association studies have identified LIPG ..
  5. ncbi Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    High-density lipoprotein (HDL) protects against atherosclerosis. Endothelial lipase (EL) has been postulated to be involved in lipoprotein, and possibly HDL, metabolism, yet the evidence has been scarce and conflicting...
  6. ncbi Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
    The LIPG gene on chromosome 18 encodes for endothelial lipase, a member of the triglyceride lipase family...
  7. ncbi Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
    Kimiko Yamakawa-Kobayashi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Tsukuba, Japan
    Hum Genet 113:311-5. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism...
  8. ncbi The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, Pavillon Paul Comtois, Office 2423, Laval University, Quebec G1K 7P4, Canada
    J Lipid Res 44:1902-8. 2003
    The objective of the present study was to examine the impact of the T111I missense mutation in exon 3 of the endothelial lipase (EL) gene on HDL and its potential interaction effect with dietary fat...
  9. ncbi Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    Na Ping Tang
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
    J Lipid Res 49:369-75. 2008
    The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) ..
  10. ncbi Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
    Endothelial cell-derived lipase (EDL) is a new member of the lipase gene family with high sequence homology with lipoprotein lipase (LPL). EDL is a phospholipase with very little triacylglycerol lipase activity...
  11. ncbi Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
    Masakatsu Shimizu
    Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ J 71:842-6. 2007
    b>Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment...
  12. ncbi Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation
    Yoko Kojma
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:54032-8. 2004
    b>Endothelial lipase (EL), a new member of the lipoprotein lipase gene family, plays a central role in high density lipoprotein metabolism...
  13. ncbi Characterization of the lipolytic activity of endothelial lipase
    Mary G McCoy
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 43:921-9. 2002
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity...
  14. ncbi Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111 1524, United States
    Atherosclerosis 206:500-4. 2009
    ..HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG).
  15. ncbi Insulin resistance and hypertension: in vivo and in vitro insulin action in skeletal muscle in spontaneously hypertensive and Wistar-Kyoto rats
    A L Swislocki
    Medical Service, Department of Veterans Affairs Northern California Health Care System, Martinez 94533, USA
    Am J Hypertens 10:1159-64. 1997
    ..increased from 377 +/- 120 to 439 +/- 175 disintegrations per minute (dpm) 3H-glucose/mg extensor digitorum longus (EDL) in WKY when insulin increased from 0 to 1000 microU/mL (P < ...
  16. ncbi Acute effects of the beta 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilisation
    Y L Liu
    Department of Physiology, St George s Hospital Medical School, Tooting, London
    Br J Pharmacol 114:888-94. 1995
    ..and potentiated the response in Type II (non-working) muscles such as tibialis and extensor digitorium longus (EDL). 4...
  17. ncbi Dissociation between insulin binding and glucose utilization after intense exercise in mouse skeletal muscles
    A Bonen
    Department of Physiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Horm Metab Res 21:172-8. 1989
    ..2-deoxy-d-glucose (2-DOG) uptake and glucose incorporation into glycogen and glycolysis were compared in soleus and EDL muscles of intensively exercised (2-3 h) mice and non-exercised mice...
  18. ncbi Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase
    Luis Da Silva-Azevedo
    Department of Physiology, Charite Campus Benjamin Franklin, Arnimallee 22, Berlin Dahlem, Germany
    J Physiol 587:655-68. 2009
    ..subsequent tandem mass spectrometry (LC-MS/MS) was performed using extracts of extensor digitorum longus muscle (EDL) derived from nNOS-knockout mice in comparison to C57Bl/6 control mice...
  19. ncbi Skeletal muscle myosin heavy chain expression in rats with monocrotaline-induced cardiac hypertrophy and failure. Relation to blood flow and degree of muscle atrophy
    G Vescovo
    First Division of Internal Medicine, Venice City Hospital, Italy
    Cardiovasc Res 39:233-41. 1998
    ..In congestive heart failure (CHF) the skeletal muscle of the lower limbs develops a myopathy characterised by atrophy and shift from the slow to the fast type fibres. The mechanisms responsible for these changes are not clear yet...
  20. ncbi Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation
    M C Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Physiol Regul Integr Comp Physiol 298:R2-8. 2010
    ..Intact extensor digitorum longus (EDL) and soleus muscles from mice were also incubated in vitro with oxypurinol or polyethylene glycol-tagged Cu,Zn-SOD...
  21. ncbi Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 139:291-304. 2011
    b>Endothelial lipase (gene: LIPG; enzyme: EL) is one of three members of the triglyceride lipase family that contributes to lipoprotein degradation within the circulation system and plays a major role in HDL metabolism in the body...
  22. ncbi Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway
    Ilia V Fuki
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:34331-8. 2003
    b>Endothelial lipase (EL) is a new member of the triglyceride lipase gene family, which includes lipoprotein lipase (LpL) and hepatic lipase (HL). Enzymatic activity of EL has been studied before...
  23. ncbi Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins
    Daniela Caiazza
    Lipid Research Group, The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia
    Biochemistry 43:11898-905. 2004
    b>Endothelial lipase (EL) is a newly identified member of the triglyceride lipase gene family that hydrolyzes high-density lipoprotein (HDL) phospholipids...
  24. ncbi In vitro 1H-NMR spectroscopic analysis of metabolites in fast- and slow-twitch muscles of young rats
    Yoshichika Yoshioka
    Department of Physiology II, School of Medicine, Iwate Medical University, Morioka, Japan
    Magn Reson Med Sci 1:7-13. 2002
    ..TAU), anserine (ANS) and carnosine (CAR) content of the masseter muscles (MM), long extensor muscles of digits (EDL) and soleus muscles (SOL) of young rats were determined using in vitro 1H-NMR spectroscopy to assess the ..
  25. ncbi Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    b>Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models...
  26. ncbi Differences in glucose transport rates between perfused and in vitro incubated muscles
    M Kern
    Department of Biochemistry, East Carolina University, School of Medicine, Greenville, North Carolina
    Horm Metab Res 22:366-8. 1990
    ..3-O-Methylglucose transport rates in incubated soleus (SOL) and extensor digitorum longus (EDL) muscle strips were compared to transport rates obtained in SOL and EDL muscles removed from perfused hindquarters...
  27. ncbi Electrostatic and electrochemical nature of liquid-gated electric-double-layer transistors based on oxide semiconductors
    Hongtao Yuan
    Quantum Phase Electronics Center and Department of Applied Physics, The University of Tokyo, Tokyo 113 8656, Japan, Japan Science and Technology Agency CREST, Kawaguchi 332 0012, Japan, Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan, and WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980 8577, Japan
    J Am Chem Soc 132:18402-7. 2010
    The electric-double-layer (EDL) formed at liquid/solid interfaces provides a broad and interdisciplinary attraction in terms of electrochemistry, photochemistry, catalysts, energy storage, and electronics because of the large interfacial ..
  28. ncbi Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model
    Nobukazu Takahashi
    Division of Diagnostic Imaging, Box 57, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Acad Radiol 14:1050-7. 2007
    ..We previously have reported that (99m)Tc-labeled glutamate peptide-estradiol ((99m)Tc-GAP-EDL) is a useful agent for imaging functional estrogen receptor (ER) via an ER-mediated process...
  29. ncbi Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat
    Robyn M Murphy
    Department of Zoology, La Trobe University, Melbourne, Victoria, Australia
    J Physiol 587:443-60. 2009
    ..the absolute amount of CSQ isoform 1 (CSQ1, the primary isoform) present in rat extensor digitorum longus (EDL) and soleus fibres, and related this to their endogenous and maximal SR Ca2+ content...
  30. ncbi Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse
    Tatiana L Radzyukevich
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 287:C1445-52. 2004
    ..After 14-day simultaneous denervation of the soleus (Sol), tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius (Gastr) muscles by sciatic nerve section, DHPR mRNA increased preferentially in the Sol and TA (..
  31. ncbi Acute effects of N-acetylcysteine on skeletal muscle microcirculation following closed soft tissue trauma in rats
    Klaus D Schaser
    Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Orthop Res 23:231-41. 2005
    ..Microcirculation of the extensor digitorum longus (EDL) muscle was analyzed using intravital microscopy and Laser-Doppler flowmetry (LDF)...
  32. ncbi Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors
    Tu Nguyen-Huu
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité Propre de Recherche 9040, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Anesthesiology 110:1011-5. 2009
    ..The basis of this difference may be a higher concentration of acetylcholine released or higher number of postsynaptic nicotinic acetylcholine receptors in diaphragmatic neuromuscular junctions...
  33. ncbi Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis
    Claire Thomas
    Universite Montpellier 1, UFR Médecine EA701, F 34295, Montpellier, France
    Am J Physiol Endocrinol Metab 293:E916-22. 2007
    ..MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles...
  34. ncbi Myofascial force transmission causes interaction between adjacent muscles and connective tissue: effects of blunt dissection and compartmental fasciotomy on length force characteristics of rat extensor digitorum longus muscle
    P A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Physiol Biochem 109:97-109. 2001
    Muscles within the anterior tibial compartment (extensor digitorum longus: EDL, tibialis anterior: TA, and extensor hallucis longus muscles: EHL) and within the peroneal compartment were excited simultaneously and maximally...
  35. ncbi Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism
    Gentian Lluri
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Neurobiol 66:1365-77. 2006
    ..report that TIMP-2 is expressed at the NMJ and its expression is greater in fast-twitch (extensor digitorum longus, EDL) than slow-twitch (soleus) muscle...
  36. ncbi Myofascial force transmission via extramuscular pathways occurs between antagonistic muscles
    Peter A Huijing
    Research Instituut Move, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    Cells Tissues Organs 188:400-14. 2008
    ..force was measured simultaneously at: (1) the proximal and distal tendons of the extensor digitorum muscle (EDL) to quantify any proximo-distal force differences, as an indicator of myofascial force transmission, (2) at the ..
  37. ncbi Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation
    Blake C Beehler
    Cardiovascular and Metabolic Diseases Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08543, USA
    Exp Biol Med (Maywood) 231:335-41. 2006
    ..At the end of the study, the rats were euthanized and the soleus and extensor digitorum longus (EDL) muscles were harvested. In vehicle-treated rats, denervation caused a 33.5 +/- 2.8% and 16.2 +/- 2...
  38. ncbi Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels
    A De Luca
    Dipartimento Farmacobiologico, Facolta di Farmacia, Universita di Bari, Italy
    Br J Pharmacol 125:477-82. 1998
    ..2. For this purpose G(Cl) in EDL muscle isolated from adult rat was first lowered by treatment with 5 nM 4-beta-phorbol 12,13 dibutyrate (4-beta-PDB)..
  39. ncbi Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration
    Oliver Baum
    Department of Anatomy and Physiology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Königin Luise Str 15, D 14195 Berlin Dahlem, Germany
    Am J Physiol Heart Circ Physiol 287:H2300-8. 2004
    ..of capillaries/mm2) were determined in frozen sections from extensor digitorum longus (EDL) muscles of these mice...
  40. ncbi Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles
    F Yu
    Noll Physiological Research Center and Department of Cellular and Molecular Physiology, Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    Am J Physiol Regul Integr Comp Physiol 278:R1545-54. 2000
    ..In fast-twitch extensor digitorum longus (EDL) muscle, TR-alpha(1)-, TR-beta-, or TR-alpha(1)beta-deficient mice showed a small but statistically significant ..
  41. ncbi Protein diffusion in living skeletal muscle fibers: dependence on protein size, fiber type, and contraction
    S Papadopoulos
    Department of Physiology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Biophys J 79:2084-94. 2000
    ..were injected into single, intact skeletal muscle fibers taken from either soleus or extensor digitorum longus (edl) muscle of adult rats...
  42. ncbi Acute molecular response of mouse hindlimb muscles to chronic stimulation
    W A Laframboise
    Dept of Pathology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Shadyside Hospital West Wing, WG02 11, 5230 Center Ave, Pittsburgh, PA 15232, USA
    Am J Physiol Cell Physiol 297:C556-70. 2009
    ..An immediate-early growth response was present in the extensor digitorum longus (EDL) muscle (FOS, JUN, activating transcription factor 3, and musculoaponeurotic fibrosarcoma oncogene) with a similar ..
  43. ncbi 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora
    Yongping Cao
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Kita gun Kagawa 761 0793, Japan
    Bone 40:132-9. 2007
    ....
  44. ncbi Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres
    Petra Wetzel
    Zentrum Physiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany, Wetzel
    Pflugers Arch 443:762-70. 2002
    Muscle carbonic anhydrase (CA) was inhibited in fibre bundles of the extensor digitorum longus (EDL) and soleus (SOL) muscles from rats. Isometric single twitches were recorded in the absence or presence of the CA inhibitors...
  45. ncbi Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle
    Milan Holecek
    Department of Physiology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    Amino Acids 40:575-84. 2011
    ..M. soleus (SOL, slow-twitch, red muscle) and m. extensor digitorum longus (EDL, fast-twitch, white muscle) of white rat were isolated and incubated in a medium with or without 500 μM ammonia...
  46. ncbi Vinculin and meta-vinculin in fast and slow rat skeletal muscle before and after hindlimb suspension
    Angèle Chopard
    Laboratoire de Physiologie Cellulaire et Moléculaire Des Systèmes Intégrés, CNRS, Unité Mixte de Recherche 6548, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Pflugers Arch 444:627-33. 2002
    ..the expression of these proteins in a slow-twitch (soleus) and in a fast-twitch (extensor digitorum longus, EDL) skeletal muscle under control conditions and after a reduced functional demand...
  47. ncbi A comparison of the electrophysiological effects of two organophosphates, mipafox and ecothiopate, on mouse limb muscles
    G E de Blaquière
    Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, United Kingdom
    Toxicol Appl Pharmacol 150:350-60. 1998
    ..Acetylcholinesterase activity was measured in the soleus (slow-twitch) and extensor digitorum longus (EDL; fast-twitch) muscles...
  48. ncbi Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I
    A Jahangiri
    Lipid Research Group, Heart Research Institute, Camperdown, Sydney, New South Wales 2050, Australia
    J Lipid Res 46:896-903. 2005
    b>Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity...
  49. ncbi Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
    ..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
  50. ncbi Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage
    A Lionikas
    Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Physiol Genomics 16:141-52. 2003
    ..slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C57BL/6J (B6) than in DBA/2J (D2) mice...
  51. ncbi Contractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II
    Matthew D Beekley
    Zentrum Physiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Pflugers Arch 452:453-63. 2006
    ..Because of this, we compared the in vitro contractile properties of extensor digitorum longus (EDL) and soleus (SOL) fibre bundles from mice deficient in CA II (CAD) to litter mate controls (LM)...
  52. ncbi Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
    ..The sedentary control animals remained in their cages. For each animal, Po was determined in the fast-twitch EDL and slow-twitch soleus muscles from one hindlimb and quantitative measurements of [Ca2+]i were made in the ..
  53. ncbi Tetanus relaxation of fast skeletal muscles of the mouse made parvalbumin deficient by gene inactivation
    J M Raymackers
    Departement de Physiologie, Universite Catholique de Louvain, B 1200 Bruxelles, Belgium
    J Physiol 527:355-64. 2000
    The effects of tetanus duration on the relaxation rate of extensor digitorum longus (EDL) and flexor digitorum brevis (FDB) muscles were studied in normal (wild-type, WT) and parvalbumin-deficient (PVKO) mice, at 20 C...
  54. ncbi The relationship between skeletal muscle proteolysis and ubiquitin-proteasome proteolytic pathway in burned rats
    Jiake Chai
    Department of Burns and Plastic Surgery, Burns Institute, 304th Hospital, Beijing 100037, China
    Burns 28:527-33. 2002
    ..The proteolytic rates and mRNA expression of ubiquitin, E2-14K, and subunit RC2 in extensor digital longus (EDL) and soleus (SOL) muscle were determined by amino acid analyzer and Northern blot, respectively...
  55. ncbi Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice
    G J Etgen
    Pfizer Central Research, Eastern Point Road, Groton, CT 06340, USA
    Biochem J 337:51-7. 1999
    ..mannos-4-yloxy)-2-propylamine photolabelling methodology in both isolated and perfused extensor digitorum longus (EDL). Cell-surface GLUT1 was enhanced by as much as 70-fold in both isolated and perfused EDL of transgenic mice...
  56. ncbi Treating retinoblastoma in tissue culture and in a rat model with a novel isoquinoline derivative
    Mohamed Nassr
    Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Invest Ophthalmol Vis Sci 51:3813-9. 2010
    PURPOSE. To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblastoma in vitro and in vivo. METHODS...
  57. ncbi Decreased monocarboxylate transporter 1 in rat soleus and EDL muscles exposed to clenbuterol
    T Kitaura
    Faculty of Pharmaceutical Sciences, University of Kanazawa, Kakuma, Kanazawa 920 1192, Japan
    J Appl Physiol 91:85-90. 2001
    ..LDH) and isoform pattern and shift myosin heavy chain (MHC) pattern in soleus (Sol) and extensor digitorum longus (EDL) of male rats. In the clenbuterol-administered rats (2...
  58. ncbi Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration
    Martin Fluck
    M E Müller Institute for Biomechanics, University of Bern, Bühlestrasse 26, 3000 Bern 9, Switzerland
    J Exp Biol 205:2337-48. 2002
    ..type IIA fibres in normal rat soleus (N-SOL) muscle and of the type IIA fibres in extensor digitorum longus (N-EDL) muscle...
  59. ncbi Post-effects of nandrolone decanoate treatment on contractile responses of rat skeletal muscles
    Wissam H Joumaa
    Laboratoire de Physiologie Generale, CNRS UMR 6018, Faculte des Sciences et des Techniques, Universite de Nantes, B P 92208, 44322 Nantes, France
    Jpn J Physiol 52:479-87. 2002
    ..on contractile responses of isolated small bundles of intact slow-(soleus) and fast-(extensor digitorum longus, edl) twitch fibers in rat...
  60. ncbi The role of ascorbic acid and exercise in chronic ischemia of skeletal muscle in rats
    T Loizidis
    Laboratory of Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Appl Physiol 102:321-30. 2007
    ..on muscle performance, cross-sectional area, and ultrastructural morphology in extensor digitorum longus (EDL) and soleus (Sol) muscles in rats...
  61. ncbi Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles
    Cyril Bozzo
    Department of Anatomy and Physiology, University of Padova, Italy
    FEBS J 272:5771-85. 2005
    ..chains (MLC1) and regulatory myosin light chains (MLC2) in rat slow (soleus) and fast (extensor digitorum longus EDL) muscles using 2D-gel electrophoresis and mass spectrometry...
  62. ncbi Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
    J G Kemp
    1 School of Biomedical and Health Sciences, Victoria University, Footscray, Victoria, Australia
    Int J Obes (Lond) 33:831-41. 2009
    ..Knowledge of the morphological and biochemical alterations occurring in skeletal muscles of obese animals is relatively limited, particularly with respect to non-limb muscles and relationship to fibre type...
  63. ncbi Mitochondrial superoxide production in skeletal muscle fibers of the rat and decreased fiber excitability
    Chris van der Poel
    Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Autralia
    Am J Physiol Cell Physiol 292:C1353-60. 2007
    ..responses were measured at 37 degrees C in mechanically skinned muscle fibers of rat extensor digitorum longus (EDL) muscle. In mechanically skinned fibers, the sarcolemma is removed avoiding potential sources of O(2)(...
  64. ncbi Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice
    Benjamin T Corona
    Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, GA 30302 3975, USA
    J Appl Physiol 105:1542-53. 2008
    ..RYR1Y522S/wt) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (EDL) muscles] damage and strength deficits following the performance of a single or repeated bouts of eccentric ..
  65. ncbi Myosin heavy chain expression in skeletal muscle autografts under neural or aneural conditions
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Surg Res 75:135-47. 1998
    ....
  66. ncbi Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
    J Clin Microbiol 41:4930-40. 2003
    The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into five "seropathotypes" (A through E) based on the reported ..
  67. ncbi Role of load bearing in acetylcholinesterase regulation in rat skeletal muscles
    Peter Pregelj
    Institute of Pathophysiology, School of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Neurosci Res 67:114-21. 2002
    ..The levels of AChE mRNA in the slow soleus muscles are about 30% of those in the fast extensor digitorum longus (EDL) muscles...
  68. ncbi Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    Iulia Iatan
    Department of Biochemistry, Cardiovascular Research Laboratories, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 2:467-75. 2009
    ..HDL particles are modulated by a variety of lipases, including endothelial lipase, a phospholipase present on vascular endothelial cells...
  69. ncbi Muscle fiber type composition and morphometric properties of denervated rat extensor digitorum longus muscle
    D Bobinac
    Department of Anatomy, Rijeka University School of Medicine, Brace Branchetta 22, 51000 Rijeka, Croatia
    Croat Med J 41:294-7. 2000
    Analysis of fiber type composition and fiber size of extensor digitorum longus (EDL) muscle in rats during 30 days of denervation.
  70. ncbi Expression of the skeletal calsequestrin isoform in normal and regenerated skeletal muscles and in the hearts of rats with altered thyroid status
    T Soukup
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 61:575-86. 2012
    ..Muscle regeneration was achieved by intramuscular grafting of either soleus or extensor digitorum longus (EDL) from 3- to 4-week-old rats to either EDL or soleus muscle of 2-month-old rats...
  71. ncbi The effect of a unilateral muscle transplantation on the muscle fiber type and the MyHC isoform content in unoperated hind limb slow and fast muscles of the inbred Lewis rats
    G ZACHAROVA
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Physiol Res 54:691-6. 2005
    ..the myosin heavy chain (MyHC) isoform expression in the rat slow soleus (SOL) and fast extensor digitorum longus (EDL) muscles, a method of heterochronous isotransplantation was developed...
  72. ncbi The effect of partial denervation of developing rats fast muscles on their motor unit properties
    F Tyc
    Department of Anatomy and Developmental Biology, Centre for Neuroscience, UCL, London, UK
    J Physiol 482:651-60. 1995
    1. The effects of partial denervation on motor units of the fast twitch extensor digitorum longus (EDL) muscle of the rat were studied. 2...
  73. ncbi Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase
    Joanne M Wroblewski
    Department of Internal Medicine, Endocrinology Division and Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 52:2255-61. 2011
    Inflammation is associated with significant decreases in plasma HDL-cholesterol (HDL-C) and apoA-I levels. Endothelial lipase (EL) is known to be an important determinant of HDL-C in mice and in humans and is upregulated during ..
  74. ncbi Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties
    Joan Carles Escola-Gil
    IIB Sant Pau 08025 Barcelona, Spain
    Biochim Biophys Acta 1831:691-7. 2013
    Hepatic lipase (HL) and endothelial lipase (EL) are negative regulators of plasma HDL cholesterol (HDLc) levels and presumably could affect two main HDL atheroprotective functions, macrophage-to-feces reverse cholesterol transport (RCT) ..
  75. ncbi Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres
    R M Murphy
    Department of Zoology, La Trobe University, Melbourne 3086, Victoria, Australia
    J Physiol 586:2203-16. 2008
    ..Here, using skinned fibres from rat extensor digitorum longus (EDL) and soleus muscle, it is shown that although H(2)O(2) (> or = 100 microm) has little effect by itself, when added ..
  76. ncbi Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway
    Yasuki Higaki
    Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Am J Physiol Endocrinol Metab 294:E889-97. 2008
    ..Exposure of isolated rat extensor digitorum longus (EDL) muscles to Hx/XO (Hx/XO) for 20 min resulted in a dose-dependent increase in glucose uptake...
  77. ncbi A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
    Robert J Brown
    Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Lipid Res 50:1910-6. 2009
    Human endothelial lipase (EL) is a member of a family of lipases and phospholipases that are involved in the metabolism of plasma lipoproteins. EL displays a preference to hydrolyze lipids in HDL...
  78. ncbi Endothelial lipase is increased in vivo by inflammation in humans
    Karen O Badellino
    School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 117:678-85. 2008
    b>Endothelial lipase (EL) is a plasma lipase that we previously reported to be significantly correlated with all features of the metabolic syndrome in humans, including directly with measures of adiposity and inversely with high-density ..
  79. ncbi Modification of motoneuron size after partial denervation in neonatal rats
    F Tyc
    Laboratoire Plasticité et Physio Pathologie de la Motricité, UMR 6196, CNRS, Marseille Cedex, France
    Arch Ital Biol 145:337-44. 2007
    Our previous studies have shown that partial denervation of extensor digitorum longus muscle (EDL) in the rat at 3 days of age causes an increase in the activity of the intact motoneurons...
  80. ncbi [Significance of the ratio of circulating endothelial cell expressing endothelial lipase and supersensitivity C-reactive protein in prognosis of patients with coronary artery disease]
    Yu qiang Fang
    Research Institute of Angiocardiopathy, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19:644-6. 2007
    To evaluate the significance of the ratio of circulating endothelial cell expressing endothelial lipase (EL(+)/CECs) and supersensitivity C-reactive protein (hsCRP) in prognosis of patients with coronary artery disease (CAD).
  81. ncbi Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia
    Hanayo Tanaka
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Atheroscler Thromb 16:327-38. 2009
    ..b>Endothelial lipase (EL) is a determinant of plasma HDL levels...
  82. ncbi Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection
    Naiara Schaffazick
    Programa de Farmacologia Celular e Molecular, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Av Carlos Chagas Filho, 373, CCS ICB Bl J, sala J 17, Rio de Janeiro, RJ 21941 902, Brazil
    Toxicon 55:52-60. 2010
    ..the effect of local injection of Bothrops jararacussu venom in mouse fast-twitch extensor digitorum longus (EDL) muscle, without or with heparin, on functional/molecular alterations of two central proteins involved in ..
  83. ncbi Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy
    Mireia Arnedo
    Institute of Microbiology, University of Lausanne, Switzerland
    Pharmacogenet Genomics 17:755-64. 2007
    ..Single nucleotide polymorphisms in multiple genes involved in lipid transport and metabolism are presumed to modulate the risk of dyslipidemia in response to antiretroviral therapy...
  84. ncbi Effects of dexamethasone on the expression of beta(1)-, beta (2)- and beta (3)-adrenoceptor mRNAs in skeletal and left ventricle muscles in rats
    Fuuun Kawano
    Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, 2 579 15 Mikajima, Tokorozawa, Saitama, 359 1192, Japan
    J Physiol Sci 59:383-90. 2009
    ..of the beta(1)-, beta(2)-, and beta(3)-AR mRNAs and GR mRNA in fast-twitch fiber-rich extensor digitorum longus (EDL), slow-twitch fiber-rich soleus (SOL), and left ventricle (LV) muscles by real-time quantitative RT-PCR...
  85. ncbi Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime
    Ekaterina Gongadze
    Institute of General Electrical Engineering, University of Rostock, Albert Einstein Straße 2, 18051, Rostock, Germany
    Cell Mol Biol Lett 16:576-94. 2011
    ..body fluid (electrolyte solution) leads to ion redistribution and thus to formation of an electrical double layer (EDL)...
  86. ncbi Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:e207-15. 2010
    The aim of this study was to investigate endothelial lipase (EL, LIPG) and lipoprotein lipase (LPL) mRNA and protein expression in normal human testis and testicular germ cell tumours (GCT)...
  87. ncbi Sex, fiber-type, and age dependent in vitro proliferation of mouse muscle satellite cells
    Raquel Manzano
    LAGENBIO I3A, Aragońs Institute of Health Sciences IACS, Universidad de Zaragoza, Zaragoza, Spain
    J Cell Biochem 112:2825-36. 2011
    ..origin on in vitro properties of satellite cells derived from postnatal muscles, fast extensor digitorum longus (EDL) and slow soleus (SOL) muscles were extracted from male and female mice of 1 week to 3 months of age...
  88. ncbi The importance of ion size and electrode curvature on electrical double layers in ionic liquids
    Guang Feng
    Department of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634 0921, USA
    Phys Chem Chem Phys 13:1152-61. 2011
    ..The sizes of the counter-ion and co-ion affect the ion distribution and orientational structure of EDLs. The EDL capacitances near both planar and cylindrical electrodes were found to follow the order: [BMIM][Cl] (near the ..
  89. ncbi In isolated skeletal muscle, excitation may increase extracellular K+ 10-fold; how can contractility be maintained?
    Torben Clausen
    Department of Physiology and Biophysics, University of Aarhus, Ole Worms Alle 4, DK 8000 Arhus C, Denmark
    Exp Physiol 96:356-68. 2011
    ..can be quantified using flame photometry and compared with contractile performance in extensor digitorum longus (EDL) and soleus muscles...
  90. ncbi T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle
    Janine Hallerdei
    Molecular and Cell Physiology, Vegetative Physiologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 5:e15137. 2010
    We have studied lactic acid transport in the fast mouse extensor digitorum longus muscles (EDL) by intracellular and cell surface pH microelectrodes...
  91. ncbi Functional overloading of dystrophic mice enhances muscle-derived stem cell contribution to muscle contractile capacity
    Fabrisia Ambrosio
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Phys Med Rehabil 90:66-73. 2009
    ....
  92. ncbi Dynamics of muscle fibre growth during postnatal mouse development
    Robert B White
    King s College London, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London SE1 1UL, UK
    BMC Dev Biol 10:21. 2010
    ..Where myofibre hypertrophy during growth requires the addition of new myonuclei, these are supplied by muscle satellite cells, the resident stem cells of skeletal muscle...
  93. ncbi Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
    ....
  94. ncbi The effects of magnetic field on the biomechanics parameters of soleus and extensor digitorum longus muscles in rats with streptozotocin-induced diabetes
    A Pelit
    Biophysics Department, Cukurova University Medical Faculty, Adana, Turkey
    Diabetes Technol Ther 10:294-8. 2008
    The aim of this study was to determine the effects of the magnetic field (MF) on the isometric contractile characteristics of the soleus and extensor digitorum longus (EDL) muscles in rats both with and without diabetes.
  95. ncbi [The -384A >C polymorphism of endothelial lipase gene promoter region in Chinese healthy normolipidemic and endogenous hypertriglyceridemic subjects]
    Yi Huang
    West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041 People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:443-6. 2008
    To investigate the effects of the -384A>C polymorphism in the promoter region of endothelial lipase (EL) gene on serum lipid and apolipoprotein levels in healthy normolipidemic (HTG) and endogenous hypertriglyceridemic (HTG) subjects.
  96. ncbi Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
    Troy L Merry
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 298:E577-85. 2010
    ..Isolated extensor digitorum longus (EDL) and soleus muscles from mice that expressed a muscle-specific kinase dead AMPKalpha2 isoform (AMPK-KD) and wild-..
  97. ncbi Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure
    Raquel Santilone Bertaglia
    Department of Morphology, Institute of Biosciences, UNESP, Sao Paulo State University, 18618 000 Botucatu, SP, Brazil
    J Mol Histol 42:205-15. 2011
    ..and gene expression in Soleus (SOL--oxidative and slow twitching muscle) and in Extensor Digitorum Longus (EDL--glycolytic and fast twitching muscle) during HF...
  98. ncbi Increase of the cytotoxic effect of Bothrops jararacussu venom on mouse extensor digitorum longus and soleus by potassium channel blockers and by Na(+)/K(+)-ATPase inhibition
    Marcelo A Tomaz
    Departamento de Farmacologia Basica e Clinica, ICB, CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
    Toxicon 52:551-8. 2008
    ..of Bothrops jararacussu crude venom and other cytolytic agents on mouse isolated extensor digitorum longus (EDL) and soleus (SOL) muscles, which present distinct properties: EDL is a fast-twitch, white muscle with predominantly ..
  99. ncbi Functional regeneration in the hindlimb skeletal muscle of the mdx mouse
    J E Anderson
    Department of Anatomy, University of British Columbia, Vancouver, Canada
    J Muscle Res Cell Motil 9:499-515. 1988
    ..properties, histochemical staining and myosin light chain and parvalbumin contents of extensor digitorum longus (EDL) and soleus (Sol) muscles of mdx and age-matched control mice were studied at 3-4 and 32 weeks...
  100. ncbi Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors
    Catarina Johansson
    Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Physiol 547:789-96. 2003
    ..of specific muscle enzymes was studied in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles in mice deficient in all known subtypes of thyroid hormone receptors (i.e...
  101. ncbi Remodeling in the microcirculation of rat skeletal muscle during chronic ischemia
    M D Brown
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    Microcirculation 10:179-91. 2003
    ..To establish the time course and extent of remodeling of terminal microcirculation in ischemic rat skeletal muscle during prolonged low flow that does not lead to inflammation...

Research Grants65

  1. SKELETAL MUSCLE ENERGY METABOLISM
    Martin Kushmerick; Fiscal Year: 1993
    ..kinetics under homogenous in vitro conditions are different from those in isolated mouse extensor digitorum longus (EDL) and soleus (SOL) muscles by measuring the forward and reverse fluxes between PCr and gammaATP catalyzed by CK in ..
  2. High Density Lipoprotein Metabolism Influence of Extracellular Phospholipases
    Daniel Rader; Fiscal Year: 2007
    ..We cloned and characterized a new member of the lipase gene family that we termed endothelial lipase (EL)...
  3. Role of Endothelial Lipase in Atherosclerosis
    HAMID RAZZAGHI; Fiscal Year: 2007
    ..Recently, a newly discovered gene, called endothelial lipase (EL), has been shown to have several unique features that make EL a prime candidate gene for low HDL-C and ..
  4. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  5. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-C levels...
  6. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2010
    ..all enzymes that utilize PC as substrate will be tested with respect to secretory phospholipases and endothelial lipase. The inhibitory role of SM in the generation of pro-inflammatory oxidized PCs and oxysterols will be tested ..
  7. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006
    ..The focus of the research project is endothelial lipase (EL), a member of the triglyceride lipase family that has been shown, in mouse over expression studies, to ..
  8. The Role of Apolipoprotein A-II in the Modulation of HDL Function
    RANASINGHE SILVA; Fiscal Year: 2007
    ..HDL remodeling factors including lecithin:cholesterol acyl transferase (LCAT), hepatic lipase (HL), and endothelial lipase (EL)...
  9. Androgen targets in a simple behavioral system
    Cynthia Jordan; Fiscal Year: 2003
    ..the cells in rat muscles that express ARs, comparing the levator ani (LA) to the extensor digitorum longus (EDL), which differ in their sensitivity to androgens...
  10. E. coli O157:H7 genes induced during human infection
    INDIRA KUDVA; Fiscal Year: 2005
    ..The genes contained in reactive clones will be identified by BLAST, against the genomes of O157 EDL 933 and Sakai strains, and other DNA sequences available in the National Center for Biotechnology Information (NCBI)..
  11. SINGLE SKETETAL MUSCLE FIBER IMPAIRMENT WITH AGING
    Osvaldo Delbono; Fiscal Year: 2001
    ..with alterations in sarcoplasmic reticulum calcium release in single fast- twitch extensor digitorum longus (EDL) muscle fibers from young (8 months), middle age (18), and old (28) Fisher 344 Brown Norway F1 Hybrid rats (..
  12. EXERCISE, DENERVATION AND INSULIN RESISTANCE IN MUSCLE
    Paul Pilch; Fiscal Year: 2005
    ..the basis for the inhibition of insulin-stimulated glycogen synthesis in the denervated extensor digitorum longus (EDL) muscle and its restoration by incubation with AICAR...
  13. HDL METABOLISM:INFLUENCE OF EXTRACELLULAR PHOSPHOLIPASES
    Daniel Rader; Fiscal Year: 2003
    ..reported the isolation and characterization of a new member of the lipoprotein lipase gene family termed endothelial lipase (EL) that is made by endothelial cells and has primarily phospholipase activity...
  14. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2007
    ..This will be accomplished in two stages: (i) initially the weight of soleus, tibialis anterior (TA), EDL, gastrocnemius and biceps brachii (BB) muscles will be measured in congenic C57BL/6...
  15. Alcohol and Chronic Disease Among Vulnerable Populations
    Eric Rimm; Fiscal Year: 2007
    ..alcohol dehydrogenase-3, hepatic lipase, lipoprotein lipase, cholesteryl ester transport protein, and endothelial lipase. The well characterized large cohorts of women and men with stored blood samples provide an unparalleled ..
  16. MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
    Marcia Ontell; Fiscal Year: 2004
    ..By transplanting newborn Myf 5 null extensor digitorum longus (EDL) muscles into the bed of normal hosts (where these muscle regenerate and become innervated), we can compare these ..