LIPC

Summary

Gene Symbol: LIPC
Description: lipase, hepatic
Alias: HDLCQ12, HTGL, LIPH, hepatic lipase, hepatic triacylglycerol lipase, lipase member C
Species: human

Top Publications

  1. doi Tissue distribution of lipase genes related to triglyceride metabolism in laying hens (Gallus gallus)
    Kan Sato
    Animal Science, Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu shi, Tokyo, 183 8509, Japan
    Comp Biochem Physiol B Biochem Mol Biol 155:62-6. 2010
  2. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
  3. ncbi Hepatic lipase: a marker for cardiovascular disease risk and response to therapy
    Alberto Zambon
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Curr Opin Lipidol 14:179-89. 2003
  4. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
  5. doi Quantitative assessment of the effect of hepatic lipase gene polymorphism on the risk of coronary heart disease
    Hairong Wang
    Department of Cardiology, Shanghai Pudong New Area Gongli Hospital, PR China
    Arch Med Res 41:383-90. 2010
  6. ncbi The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese
    Yu Lin Ko
    The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, No 199 Tung Hwa North Road, Taipei, Taiwan, ROC
    Atherosclerosis 172:135-42. 2004
  7. pmc Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 52:4663-70. 2011
  8. ncbi Hepatic lipase: a pro- or anti-atherogenic protein?
    Hans Jansen
    Department of Biochemistry, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Lipid Res 43:1352-62. 2002
  9. doi The environmental and genetic evidence for the association of hyperlipidemia and hypertension
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, Republic of China
    J Hypertens 27:251-8. 2009
  10. pmc The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype
    John D Brunzell
    University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Box 356426, 1959 NE Pacific Avenue, Seattle, Washington 98195, USA
    Biochim Biophys Acta 1821:365-72. 2012

Detail Information

Publications168 found, 100 shown here

  1. doi Tissue distribution of lipase genes related to triglyceride metabolism in laying hens (Gallus gallus)
    Kan Sato
    Animal Science, Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu shi, Tokyo, 183 8509, Japan
    Comp Biochem Physiol B Biochem Mol Biol 155:62-6. 2010
    The triglyceride lipase gene family, including lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL), carboxyl ester lipase (CEL), endothelial lipase (EL), Lipase H, hormone sensitive lipase (HSL) and adipose triglyceride lipase (..
  2. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258)...
  3. ncbi Hepatic lipase: a marker for cardiovascular disease risk and response to therapy
    Alberto Zambon
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Curr Opin Lipidol 14:179-89. 2003
    b>Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties...
  4. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..In addition, our data revealed strong association signals with alleles at two loci (LIPC, P = 1.3 x 10(-7); CETP, P = 7...
  5. doi Quantitative assessment of the effect of hepatic lipase gene polymorphism on the risk of coronary heart disease
    Hairong Wang
    Department of Cardiology, Shanghai Pudong New Area Gongli Hospital, PR China
    Arch Med Res 41:383-90. 2010
    The human hepatic lipase (LIPC) is a glycoprotein member of the lipase superfamily that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its enzyme function as a key factor in lipoprotein ..
  6. ncbi The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese
    Yu Lin Ko
    The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, No 199 Tung Hwa North Road, Taipei, Taiwan, ROC
    Atherosclerosis 172:135-42. 2004
    b>Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and plays a key role in reverse cholesterol transport...
  7. pmc Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 52:4663-70. 2011
    ..There is little information about which genes influence drusen accumulation. Discovery of genetic variants associated with drusen may lead to prevention and treatments of AMD in its early stages...
  8. ncbi Hepatic lipase: a pro- or anti-atherogenic protein?
    Hans Jansen
    Department of Biochemistry, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Lipid Res 43:1352-62. 2002
    b>Hepatic lipase (HL) plays a role in the metabolism of pro- and anti-atherogenic lipoproteins affecting their plasma level and composition. However, there is controversy regarding whether HL accelerates or retards atherosclerosis...
  9. doi The environmental and genetic evidence for the association of hyperlipidemia and hypertension
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, Republic of China
    J Hypertens 27:251-8. 2009
    ..The present study was undertaken to compare the differences in several environmental and genetic factors between hyperlipidemia and hypertension in the Guangxi Hei Yi Zhuang population...
  10. pmc The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype
    John D Brunzell
    University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Box 356426, 1959 NE Pacific Avenue, Seattle, Washington 98195, USA
    Biochim Biophys Acta 1821:365-72. 2012
    Increased or decreased hepatic lipase (HL) activity has been associated with coronary artery disease (CAD)...
  11. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  12. pmc Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study
    Mohammad Ali Kashani Farid
    Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, I R Iran
    Lipids Health Dis 9:96. 2010
    ..Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.
  13. doi Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis
    Selma M Soyal
    Department of Laboratory Medicine, Paracelsus Medical University, Mullner Hauptstr 48, 5020 Salzburg, Austria
    Atherosclerosis 216:374-80. 2011
    HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other...
  14. pmc Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ophthalmology 117:1989-95. 2010
    A genetic variant in the high-density lipoprotein (HDL) cholesterol pathway, hepatic lipase (LIPC), was discovered to be associated with advanced age-related macular degeneration (AMD) in a genome-wide association study...
  15. doi Hepatic lipase promoter C-480T polymorphism is associated with serum lipids levels, but not subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study
    Y M Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, University of Tampere, FI 33521 Tampere, Finland
    Clin Genet 76:46-53. 2009
    The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease...
  16. ncbi High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants
    Bernadette A C van Acker
    Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands
    Atherosclerosis 200:161-7. 2008
    Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties...
  17. ncbi The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study
    Boryana Todorova
    Department of Medicine, University of Kuopio, 70210 Kuopio
    J Clin Endocrinol Metab 89:2019-23. 2004
    ..We investigated whether the G-250A polymorphism of the hepatic lipase gene (LIPC) predicts the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish ..
  18. ncbi Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:2680-7. 2007
    Polymorphisms in the hepatic lipase (LIPC -514C > T) and cholesteryl ester transfer protein (CETP I405V) genes affect high-density lipoprotein cholesterol (HDL-c) levels, but their relationship with cardiovascular disease and their ..
  19. doi Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients
    Pedro Valdivielso
    Hospital Virgen de la Victoria, Departamento de Medicina y Dermatologia, Universidad de Malaga, 29010 Malaga, Spain
    J Diabetes Complications 22:273-7. 2008
    This study aimed to investigate the association between a polymorphism in the hepatic lipase (LIPC) gene promoter and the presence of peripheral arterial disease (PAD) in persons with type 2 diabetes.
  20. doi No association of lipase C polymorphisms with Alzheimer's disease
    S M Laws
    Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU Munchen, Munich, Germany
    Neurobiol Aging 31:2192-3. 2010
    b>Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism...
  21. pmc Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Li Meng
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:28. 2010
    The association between -250G>A polymorphism in the promoter region of the hepatic lipase gene (LIPC) and plasma high-density lipoprotein cholesterol (HDL-C) concentration is contradictory in diverse ethnics...
  22. pmc Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study
    Alanna M Chamberlain
    Division of Epidemiology and Community Health, University of Minnesota, School of Public Health, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, United States
    Atherosclerosis 200:322-8. 2008
    ..and LDL-c levels, as well as the associations between the cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC C-514T), and lipoprotein lipase (LPL Ser447Stop) genes and HDL-c levels are significantly modified by ..
  23. pmc Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease
    Haiyan Zhu
    Department of Physiology and Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
    Neurobiol Aging 29:793-4. 2008
    Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD)...
  24. ncbi CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
    Mutsuko Takata
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 111:325-31. 2006
    CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-..
  25. ncbi Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study
    Rolf V Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Am Coll Cardiol 41:1972-82. 2003
    We investigated associations between single nucleotide polymorphisms (SNPs) in the hepatic lipase promoter, levels of high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  26. ncbi Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Circulation 106:2315-21. 2002
    ..b>Hepatic lipase (HL) is a key determinant of HDL metabolism...
  27. ncbi Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency
    R A Hegele
    Department of Medicine, University of Toronto, Ontario, Canada
    Biochem Biophys Res Commun 179:78-84. 1991
    In a kindred with three hyperlipidemic subjects who had premature atherosclerosis and complete deficiency of hepatic lipase activity, we had previously identified a novel structural hepatic lipase gene variant...
  28. ncbi The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
    S Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Lipidol 9:211-9. 1998
    ..role in the hydrolysis of lipoprotein triglycerides and phospholipids, recent studies have implicated hepatic lipase in other aspects of cellular lipid and/or lipoprotein metabolism and atherosclerosis...
  29. ncbi Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase
    Kun Qian
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Atherosclerosis 195:66-74. 2007
    Increased expression of catalytically inactive hepatic lipase (ciHL) lowers remnants and low-density lipoproteins (LDL) and may reduce atherosclerosis in mice lacking both LDLreceptors (LDLR) and murine (m) HL...
  30. pmc LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion
    Mary F Feitosa
    Division of Statistical Genomics, Center for Genome Sciences, Washington University School of Medicine, St Louis, MO, 63108 2212, USA
    Atherosclerosis 204:171-7. 2009
    ..b>Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage region and ..
  31. ncbi The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis
    Aaron Isaacs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3858-63. 2004
    Investigations of the -514 C-->T single nucleotide polymorphism (SNP) in the hepatic lipase (HL) gene promoter region (LIPC) have yielded contradictory results regarding its association with changes in plasma lipids...
  32. doi The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
    b>Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein.
  33. ncbi The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    J Zacharova
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Intern Med 257:185-93. 2005
    ..b>Hepatic lipase gene encoding a lipolytic enzyme participating in remodelling of plasma lipoproteins and formation of serum ..
  34. ncbi Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    We investigated the associations between the hepatic lipase gene (LIPC) -514C>T polymorphism and lipases, lipoproteins, and insulin sensitivity (Si) responses to exercise training...
  35. ncbi Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects
    Marilu Fiegenbaum
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Chim Acta 362:182-8. 2005
    ..Polymorphisms in apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC), proteins with major roles in lipid metabolism and homeostasis have been shown associated with lipid-..
  36. ncbi Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter
    Laura E Rufibach
    Department of Medical Genetics, University of Washington, Seattle, USA
    J Lipid Res 47:1463-77. 2006
    b>Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease...
  37. ncbi The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study
    Virpi Lindi
    University of Kuopio, Department of Clinical Nutrition, P O Box 1627, FIN 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 18:88-95. 2008
    b>Hepatic lipase (HL) catalyzes the hydrolysis of triglycerides and phospholipids from lipoproteins, and promotes the hepatic uptake of lipoproteins...
  38. ncbi Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression
    Gert Jan Botma
    COEUR Cardiovascular Research School, Department of Biochemistry, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Atherosclerosis 179:61-7. 2005
    b>Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism...
  39. ncbi The -250G/A polymorphism in the hepatic lipase gene promoter influences the postprandial lipemic response in healthy men
    Y Jimenez-Gomez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda Menendez Pidal, S N, 14004 Cordoba, Spain
    Nutr Metab Cardiovasc Dis 18:173-81. 2008
    The -250G/A promoter polymorphism of the hepatic lipase gene has been associated with changes in the activity of the enzyme...
  40. doi Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults
    Kevin C M Wood
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON
    Appl Physiol Nutr Metab 33:761-8. 2008
    The purpose of this study was to assess the individual and interactive effects between hepatic lipase (LIPC; C-514T, G-250A) and apolipoprotein E (APOE) (E2, E3, E4) gene polymorphisms on levels of plasma lipoprotein cholesterol and ..
  41. pmc Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD
    Marco G Baroni
    Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Italy
    BMC Med Genet 4:8. 2003
    ..genetic variables were: apolipoprotein E (Apo E), Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and the hepatic lipase (LIPC) genes...
  42. ncbi Isolation and characterization of the human hepatic lipase gene
    D Ameis
    Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073
    J Biol Chem 265:6552-5. 1990
    ..and cosmid genomic clones were isolated spanning an area of approximately 60 kilobases that contains the human hepatic lipase (HL) gene. It is composed of 9 exons spanning approximately 35 kilobases of DNA...
  43. ncbi Promoter polymorphisms of hepatic lipase gene influence HDL(2) but not HDL(3) in African American men: CARDIA study
    S H Juo
    Columbia Genome Center, Columbia University, New York, NY 10032, USA
    J Lipid Res 42:258-64. 2001
    b>Hepatic lipase encoded by the hepatic lipase gene (LIPC) is involved in the metabolism of several lipoproteins...
  44. ncbi Identification of mouse and human macrophages as a site of synthesis of hepatic lipase
    Herminia Gonzalez-Navarro
    Molecular Disease Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 43:671-5. 2002
    b>Hepatic lipase (HL) is synthesized by the liver and is also present in steroidogenic tissues...
  45. ncbi The -250G-->A polymorphism in the human hepatic lipase gene promoter affects blood lipids in Chinese
    Shuiping Zhao
    Department of Cardiology, The Second Xiangya Hospital, Central South University, 86 Renmin Middle Road, Changsha, Hunan 410011, PR China
    Clin Chim Acta 365:149-52. 2006
    Human hepatic lipase (HL) is a glycoprotein that catalyzes the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins...
  46. doi Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2
    D van Deursen
    Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
    Diabetologia 51:2078-87. 2008
    Elevated hepatic lipase (HL, also known as LIPC) expression is a key factor in the development of the atherogenic lipid profile in type 2 diabetes and insulin resistance...
  47. ncbi Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population
    F M de Andrade
    Departamento de Genetica, Instituto de Biociencias, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Clin Genet 65:390-5. 2004
    b>Hepatic lipase (HL) is a glycoprotein that plays a major role in remodeling high-density lipoprotein (HDL)...
  48. ncbi Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia
    Stefano Bertolini
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Atherosclerosis 174:57-65. 2004
    ..These findings show that several common genetic variants influence the lipid phenotype and the CAD risk in FH heterozygotes...
  49. ncbi Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations
    Jinzhen Wu
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, 530021, Nanning, Guangxi, People s Republic of China
    Lipids 43:733-40. 2008
    ..This study was designed to compare the difference in the hepatic lipase gene (LIPC) -514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and ..
  50. ncbi Effect of gene polymorphisms on lipoprotein levels in patients with dyslipidemia of metabolic syndrome
    A Stancakova
    Department of Internal Medicine IV, Faculty of Medicine, Safarik University, Kosice, Slovak Republic
    Physiol Res 55:483-90. 2006
    ..ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A polymorphism and apolipoprotein C-III (APOC3) SstI gene polymorphism on lipid levels in ..
  51. ncbi Hepatic lipase polymorphism and increased risk of peripheral arterial disease
    P Eller
    Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
    J Intern Med 258:344-8. 2005
    b>Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties...
  52. ncbi Structure of the human hepatic triglyceride lipase gene
    S J Cai
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Biochemistry 28:8966-71. 1989
    ..By primer extension, hepatic lipase mRNA initiates at an adenine 77 bases upstream of the translation initiation site...
  53. doi [Association of the hepatic lipase gene -250G/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease]
    Ming Wei
    Department of Clinical Laboratory, Zhengzhou University, Zhengzhouì Henan, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:219-22. 2009
    To investigate the association of hepatic lipase -250G/A gene promoter polymorphism with type 2 diabetes mellitus combining with coronary heart disease.
  54. ncbi Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease
    L Masana
    Servei de Medicina Interna de Reus C, St Llorenc s n 43201, Reus, Spain
    Clin Sci (Lond) 100:183-90. 2001
    Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary ..
  55. ncbi Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity
    Yasymichi Arai
    Department of Geriatric Medicine, Keio University School of Medicine, 35, Shinanomachi, Shinjyuku ku, P O Box 160 8582, Tokyo, Japan
    J Mol Med (Berl) 81:102-9. 2003
    ..investigated the associations between polymorphisms of CETP (mutations in intron 14 and exon 15, and Taq1B), hepatic lipase (C-514T), lipoprotein lipase ( PvuII and HindIII), and ATP-binding cassette transporter 1 (R219K) loci and ..
  56. ncbi Lipoprotein lipase (C/G)447 polymorphism and blood pressure in the Stanislas Cohort
    C Sass
    Unité INSERM U 525, Centre de Medecine Preventive, Vandoeuvre les Nancy, France
    J Hypertens 18:1775-81. 2000
    ..We investigated whether the LPL (C/G)447 polymorphism was associated with blood pressure (BP) levels and longitudinal changes...
  57. ncbi Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 85:55-61. 2007
    ..USF1 specifically regulates the expression of the hormone-sensitive lipase gene (HSL) in adipocytes and the hepatic lipase gene (LIPC) in the liver, which was found to be involved in liver fat accumulation...
  58. ncbi Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
    ..This is most likely due to reduced activity of the HDL-catabolic enzyme hepatic lipase (Lipc) and increased expression of HDL-cholesterol esterifying enzyme lecithin:cholesterol acyl transferase (..
  59. ncbi [Identification of Regulatory Sequence of lip Genes of Phanerochaete chrysosporium under Lignin-degradation.]
    Ming Feng Jiang
    College of Life Science, Sichuan University, Chengdu 610064, China, Email
    Yi Chuan 27:435-41. 2005
    Eleven subcloned DNA fragments from the 5'- upstream region of lipA, lipC and lipF of Phanerochaete chrysosporium were assayed by using the gel mobility shift assay(GMSA). The total proteins extracted from P...
  60. ncbi Stimulatory release of hepatic lipase activity from rat hepatocytes by ruthenium red
    T Morita
    2nd Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Higashimura, Japan
    Biol Pharm Bull 23:549-54. 2000
    Ruthenium Red (RuR; ruthenium oxychloride ammoniated) stimulated the release of hepatic lipase (HTGL) activity from primary cultured rat hepatocytes into medium in a time- and dose-dependent manner...
  61. ncbi Restored speech comprehension linked to activity in left inferior prefrontal and right temporal cortices in postlingual deafness
    Malene Vejby Mortensen
    PET Center, Aarhus University Hospital, 44 Norrebrogade, Aarhus 8000, Denmark
    Neuroimage 31:842-52. 2006
    The left inferior prefrontal cortex (LIPC) is involved in speech comprehension by people who hear normally...
  62. ncbi Characterization of sodium dodecylsulfate polyacrylamide gel electrophoresis-separated M. agalactiae membrane antigens by mass spectrometry
    Franco Carta
    Porto Conte Ricerche, S P Porto Conte Capo Caccia, 07041 Alghero SS, Italy
    Eur J Mass Spectrom (Chichester, Eng) 10:413-9. 2004
    ..Only micro sequence data obtained by MS/MS allowed us to identify LipC, described as one of the most important Mycoplasma agalactiae antigens...
  63. doi A prospective randomized multicenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation
    Stefan Schneeberger
    Department of General and Transplant Surgery, Medical University Innsbruck, Innsbruck, Austria
    Transpl Int 22:217-24. 2009
    ..3% (HTK) vs. 100% (UW) (P = 0.397). With a mean cold ischemia time of 10 h in this study, HTK and UW solutions appear to be equally suitable for perfusion and organ preservation in clinical pancreas transplantation...
  64. ncbi Low-dose colestipol plus fenofibrate: effects on plasma lipoproteins, lecithin:cholesterol acyltransferase, and postheparin lipases in familial hypercholesterolemia
    P Weisweiler
    Metabolic Research Munich, FRG
    Metabolism 38:271-4. 1989
    Effects on plasma lipoproteins, lecithin:cholesterol acyltransferase (LCAT), and postheparin lipase (LPL and HTGL) activities were studied in 18 patients with familial hypercholesterolemia during 8-week treatment periods with colestipol (..
  65. ncbi Acute pancreatitis after embolization of liver tumors: frequency and associated risk factors
    R Lopez-Benitez
    Department of Diagnostic Radiology, University of Heidelberg, Heidelberg, Germany
    Pancreatology 7:53-62. 2007
    ..7%), but it has a significant morbidity and mortality potential if associated with other complications. It usually develops early within 24 h after the LE procedure...
  66. pmc Solution behavior and activity of a halophilic esterase under high salt concentration
    Lang Rao
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 4:e6980. 2009
    ..Although the salt reliance and physiology of these extremophiles have been widely investigated, the molecular working mechanisms of their enzymes under salty conditions have been little explored...
  67. ncbi Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions
    Brian T Gold
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:6523-32. 2006
    ..temporal gyrus (MTG), bilateral anterior cingulate, anterior left inferior prefrontal cortex (aLIPC), and posterior LIPC (pLIPC). These priming effects were explored in more detail in two subsequent studies...
  68. pmc Relaxin prevents the development of severe acute pancreatitis
    Laura Iris Cosen-Binker
    RHC LICB Medical Research Institute Buenos Aires, Argentina
    World J Gastroenterol 12:1558-68. 2006
    ..Relaxin is an insulin-like hormone that has been attributed vasorelaxant properties via the nitric oxide pathway while behaving as a glucocorticoid receptor agonist...
  69. ncbi Differentiation of three biotypes of Malassezia species on human normal skin. correspondence with M. globosa, M. sympodialis and M. restricta
    C Aspiroz
    Departamento de Microbiologia y Parasitologia, Hospital Clinico Universitario, Zaragoza, Spain
    Mycopathologia 145:69-74. 1999
    ..ovale (oval yeast cells with a broad budding base, located mainly on the scalp). Pleomorphic biotype 2/M. sympodialis, most frequently found in the back, does not clearly fit into any of the Pityrosporum species...
  70. ncbi Influence of nitric oxide-donating nonsteroidal anti-inflammatory drugs on the evolution of acute pancreatitis
    Laura Iris Cosen-Binker
    Programa de Estudios Pancreáticos, Hospital de Clinicas, Departamento de Bioquimica Clinica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Shock 25:190-203. 2006
    ..AP severity was significantly ameliorated by NO-NSAIDs being the administration time essential to achieve optimal pancreatic protection that may result to be useful in the prevention of postendoscopic severe AP...
  71. ncbi Hydrogen storage based on physisorption
    L G Scanlon
    Air Force Research Laboratory, Electrochemistry and Thermal Sciences Branch, Wright Patterson AFB, Ohio 45433, USA
    J Phys Chem B 113:4708-17. 2009
    ..dilithium phthalocyanine (Li(2)Pc, C(32)H(16)Li(2)N(8)), tetrabutylammonium lithium phthalocyanine (TBA-LiPc, C(48)H(52)LiN(9)), and tetramethylammonium lithium phthalocyanine (TMA-LiPc, C(36)H(28)LiN(9))...
  72. ncbi Effects of prefrontal lesions on lexical processing and repetition priming: an ERP study
    D Swick
    Department of Neurology and Center for Neuroscience, University of California in Davis and Veterans Affairs Medical Center VANCHCS, 150 Muir Rd, Martinez, CA 94553, USA
    Brain Res Cogn Brain Res 7:143-57. 1998
    ..Functional neuroimaging experiments have reported blood flow changes in left inferior prefrontal cortex (LIPC) during tasks that involve word retrieval and semantic processing...
  73. ncbi Lipoprotein abnormalities in diabetic nephropathy
    T Hirano
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Kidney Int Suppl 71:S22-4. 1999
    ..This study included: middle-aged to older type 2 diabetic patients with normoalbuminuria, microalbuminuria, and overt albuminuria; nondiabetic patients with primary renal disease; and normal control subjects...
  74. doi Differential behaviour of Pseudomonas sp. 42A2 LipC, a lipase showing greater versatility than its counterpart LipA
    Cristina Bofill
    Department of Microbiology, Faculty of Biology, University of Barcelona, Av Diagonal 645, Barcelona, Spain
    Biochimie 92:307-16. 2010
    ..1 and I.2 allowed isolation of two secreted lipase genes, lipA and lipC, highly homologous to those of Pseudomonas aeruginosa PAO1...
  75. ncbi Frequency and characteristics of pancreatitis in patients with inflammatory bowel disease
    Marc Barthet
    Department of Gastroenterology and Hepatology, Hopital Nord, Chemin des Bourrely, Marseille, France
    Pancreatology 6:464-71. 2006
    ..The aim of this study was to describe the radiological and biological features of IBD-associated pancreatitis and assess its frequency by comparing data from IBD patients with or without a history of pancreatitis...
  76. ncbi A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2)
    M Jelani
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Clin Genet 74:184-8. 2008
    ..1, 3q27.3, and 13q14.11-q21.32, respectively. For these three loci, two genes DSG4 for LAH1 and LIPH for LAH2 have been identified. To date, only five mutations in DSG4 and two in LIPH genes have been reported...
  77. ncbi Variability in postheparin hepatic lipase activity is associated with plasma adiponectin levels in African Americans
    Jacob J Clarenbach
    Center for Human Nutrition, Donald W Reynolds Cardiovascular Clinical Research Center of the University of Texas Southwestern Medical Center and Metabolic Unit, Veterans Affairs Medical Center, Dallas, TX, USA
    J Investig Med 55:187-94. 2007
    ..The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase (HTGL) activity. Factors that regulate HTGL in African Americans are not well delineated.
  78. ncbi Tributyrin specifically induces a lipase with a preference for the sn-2 position of triglyceride in Geotrichum sp. FO401B
    Y Ota
    Department of Applied Biochemistry, Faculty of Applied Biological Science, Hiroshima University, Higashi Hiroshima, Japan
    Biosci Biotechnol Biochem 64:2497-9. 2000
    ..Lipase C hydrolysed natural fats except sardine oil preferentially at the sn-2 position, but it showed little stereoselectivity for triolein...
  79. ncbi fMRI evidence of word frequency and strength effects during episodic memory encoding
    Greig I de Zubicaray
    Centre for Magnetic Resonance, The University of Queensland, QLD 4072, Australia
    Brain Res Cogn Brain Res 22:439-50. 2005
    ..Mem. Lang. 49 (2003) 231-248]. The increased BOLD responses observed in the left inferior prefrontal cortex (LIPC) for the WF effect provide support for an AE account...
  80. doi Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis
    Satoru Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:602-10. 2010
    ..Three genes, DSG4, LIPH, and LPAR6 (P2RY5), have been reported to underlie ARH...
  81. pmc The effect of inbreeding on the distribution of compound heterozygotes: a lesson from Lipase H mutations in autosomal recessive woolly hair/hypotrichosis
    Lynn Petukhova
    Department of Dermatology, School of Public Health, Columbia University, New York, N Y 10032, USA
    Hum Hered 68:117-30. 2009
    ..that underlie autosomal recessive woolly hair (ARWH/hypotrichosis; OMIM278150), specifically P2RY5 and Lipase H (LIPH)...
  82. doi In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn D 53111, Germany
    J Invest Dermatol 129:2772-6. 2009
    ..Hair loss usually begins in early childhood, and is diffuse and progressive. Mutations in LIPH, which encodes lipase member H, have recently been shown to cause an autosomal-recessive form of HS...
  83. ncbi Phosphinidene complexes of scandium: powerful par group-transfer vehicles to organic and inorganic substrates
    Benjamin F Wicker
    Department of Chemistry and Molecular Structure Center, Indiana University, Bloomington, Indiana 47405
    J Am Chem Soc 132:3691-3. 2010
    ..When complex (PNP)Sc(CH(3))Br (1) is treated with 1 equiv of LiPH[Trip] (Trip = 2,4,6-(i)Pr(3)C(6)H(2)), the dinuclear scandium phosphinidene complex [(PNP)Sc(mu(2)-P[Trip])](2) (2) ..
  84. pmc Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
    ..and the APOA5-A4-C3-A1 cluster; SNPs associated with HDL cholesterol and apolipoprotein AI were in CETP, LPL, LIPC, APOA5-A4-C3-A1, and ABCA1; and SNPs associated with triglycerides in GCKR, BAZ1B, MLXIPL, LPL, and APOA5-A4-C3-A1...
  85. ncbi Relationship of lipoprotein lipase and hepatic triacylglycerol lipase activity to serum adiponectin levels in Japanese hyperlipidemic men
    J Kobayashi
    Department of Lifestyle related Disease, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Japan
    Horm Metab Res 37:505-9. 2005
    The aim of this study was to determine how lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (HTGL) activity relate to serum adiponectin levels.
  86. ncbi A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis
    Ghazanfar Ali
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Hum Genet 121:319-25. 2007
    ..Recently, a deletion mutation in Lipase H (LIPH) gene, located at AH locus, has been identified in two ethnic groups of Russian population...
  87. doi Extracellular enzymes affect biofilm formation of mucoid Pseudomonas aeruginosa
    Petra Tielen
    University of Duisburg Essen, Faculty of Chemistry, Biofilm Centre, Department of Aquatic Microbiology, Geibelstrasse 41, D 47057 Duisburg, Germany
    Microbiology 156:2239-52. 2010
    ..Overexpression of the extracellular lipases LipA and LipC, the esterase EstA and the proteolytic elastase LasB from plasmids revealed that some of these hydrolases affected ..
  88. ncbi Granule cell neurogenesis after status epilepticus in the immature rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1752, USA
    Epilepsia 41:S53-6. 2000
    ..We investigated seizure-induced granule cell neurogenesis in developing rat pups to study the association between hilar injury, granule cell neurogenesis, and epilepsy...
  89. pmc The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial
    Amy J Tucker
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Nutr Metab (Lond) 7:37. 2010
    ..Epidemiological studies associate consumption of whole grain foods, including breads, with reduced cardiovascular disease (CVD) risk; however, few studies have compared wheat whole grains with wheat refined grains...
  90. ncbi GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation
    Tao Bai
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland VA Medical Center, Portland, OR 97239, USA
    Carcinogenesis 29:473-9. 2008
    ..GRB-7 over-expression therefore plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification...
  91. ncbi Hyperamylasemia of uncertain significance associated with oral double-balloon enteroscopy
    Marcela Kopacova
    2nd Department of Medicine, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Hradec Kralove, Czech Republic
    Gastrointest Endosc 66:1133-8. 2007
    ..Double-balloon enterocopy (DBE) is still under evaluation, including its yield and safety aspects...
  92. ncbi The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects
    E Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Malmo University Hospital, Lund University, Sweden
    Int J Obes (Lond) 30:1442-8. 2006
    ..The aim of the present study was to investigate the role of the HSL gene promoter variant C-60G, a polymorphism which previously has been associated with reduced promoter activity in vitro, in obesity and type 2 diabetes...
  93. ncbi Mutations in lipase H cause autosomal recessive hypotrichosis simplex with woolly hair
    Liran Horev
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Am Acad Dermatol 61:813-8. 2009
    Mutations in lipase H (LIPH) are a rare cause of autosomal recessive hypotrichosis (HT) simplex.
  94. doi A large duplication in LIPH underlies autosomal recessive hypotrichosis simplex in four Middle Eastern families
    Sagi Nahum
    Laboratory of Molecular Dermatology, Department of Dermatology, Rambam Medical Center, Rambam Health Care Campus, POB 9602, 31096, Haifa, Israel
    Arch Dermatol Res 301:391-3. 2009
    ..microsatellite markers spanning all ARHS-associated loci and obtained data suggesting linkage to 3q27, encompassing LIPH, which had previously been shown to be associated with ARHS...
  95. doi Novel mutations in the P2RY5 gene in one Turkish and two Indian patients presenting with hypotrichosis and woolly hair
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, 53111 Bonn, Germany
    Arch Dermatol Res 301:621-4. 2009
    ..We and others have previously reported mutations in the P2RY5 gene and the LIPH gene as being causal factors of autosomal recessive hypotrichosis simplex with or without woolly hair...
  96. ncbi A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms
    L A Felton
    University of New Mexico Health Sciences Center, College of Pharmacy, Albuquerque, New Mexico 87131, USA
    Pharm Dev Technol 11:141-7. 2006
    ..Lithium phthalocyanine crystals (LiPC) were placed inside the dosage forms...
  97. ncbi Genes, diet and serum lipid concentrations: lessons from ethnically diverse populations and their relevance to coronary heart disease in Asia
    E Shyong Tai
    Department of Endocrinology, Singapore General Hospital, National University of Singapore, Singapore
    Curr Opin Lipidol 15:5-12. 2004
    ..Although all ethnic groups have been affected, some appear to be at particularly high risk. The basis of these ethnic differences remains poorly understood...
  98. ncbi Epileptogenesis during development: injury, circuit recruitment, and plasticity
    Raman Sankar
    Department of Pediatrics, 22 474 MDCC, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Epilepsia 43:47-53. 2002
    ..To use animal models of variable seizure induction in rats at different developmental stages to determine contributing factors for spontaneous seizures resulting from status epilepticus (SE) early in life...
  99. pmc Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA
    M E Kimple
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    EMBO J 20:4414-22. 2001
    ....
  100. ncbi Inhibitory effect of nicotinamide on enzymatic activity of selected fungal strains causing skin infection
    Anna Ciebiada-Adamiec
    Department of Clinical Microbiology, Polish Mother s Hospital Research Institute, Łódź, Poland
    Mycoses 53:204-7. 2010
    ..rubrum strains. Thus, nicotinamide exhibited biological activity towards C. albicans, T. rubrum and Trichophyton mentagrophytes, which resulted in a decrease in the activity of enzymes produced by the fungi...
  101. ncbi Assignment of the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) genes to rat chromosome 8
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Biol (Praha) 43:97-9. 1997
    Genes for the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) were assigned to chromosome 8 of the rat by the PCR analysis of somatic cell hybrids...

Research Grants81

  1. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2000
    Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  2. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2001
    Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  3. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 1999
    Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  4. HEPATIC AND LIPOPROTEIN LIPASE INDUCED REMNANT CLEARANCE
    David Chappell; Fiscal Year: 2000
    Two lipases, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL), play central roles in catabolism of chylomicrons and very low-density lipoproteins (VLDL)...
  5. MECHANISMS OF LIPASE ACTIVATION IN ALZHEIMER'S DISEASE
    LLOYD HORROCKS; Fiscal Year: 1991
    ..If increased activities are observed, then experiments will be devised to explain the activation on the basis of receptor stimulation...
  6. STRUCTURE AND FUNCTION OF HEPARIN RELEASABLE LIPASES
    Virgil Brown; Fiscal Year: 1980
    ..This enzyme, and a lipase of hepatic origin, hepatic triglyceride lipase (HTGL), whose function in lipoprotein metabolism is unclear, are released into the plasma following intravenous infusion ..
  7. GENETICS & REGULATION OF HEPATIC LIPASE
    Samir Deeb; Fiscal Year: 1999
    The long-term goals of this proposal are to define mechanisms of regulation of hepatic lipase (HL) levels and to determine how genetic variation at the HL gene locus modulates these levels under a variety of physiological and pathological ..
  8. GENETICS & REGULATION OF HEPATIC LIPASE
    Samir Deeb; Fiscal Year: 2001
    The long-term goals of this proposal are to define mechanisms of regulation of hepatic lipase (HL) levels and to determine how genetic variation at the HL gene locus modulates these levels under a variety of physiological and pathological ..
  9. GENETICS & REGULATION OF HEPATIC LIPASE
    Samir Deeb; Fiscal Year: 2000
    The long-term goals of this proposal are to define mechanisms of regulation of hepatic lipase (HL) levels and to determine how genetic variation at the HL gene locus modulates these levels under a variety of physiological and pathological ..
  10. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013
    ..Specifically, we will determine whether HDL genes (CETP, LPL, LIPC, ABCA1 and LIPG) interact with lifestyle intervention in predicting change in HDL at year 1 and 4 of the Look AHEAD ..
  11. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2009
    ..A key determinant of HDL metabolism is hepatic lipase (HL), an enzyme that catalyses the hydrolysis of triglycerides and phospholipids in lipoproteins...
  12. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2006
    ..A key determinant of HDL metabolism is hepatic lipase (HL), an enzyme that catalyses the hydrolysis of triglycerides and phospholipids in lipoproteins...
  13. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2007
    ..A key determinant of HDL metabolism is hepatic lipase (HL), an enzyme that catalyses the hydrolysis of triglycerides and phospholipids in lipoproteins...
  14. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
    ..A key determinant of HDL metabolism is hepatic lipase (HL), an enzyme that catalyses the hydrolysis of triglycerides and phospholipids in lipoproteins...
  15. White matter hypoxia in a novel model of MMP-mediated inflammation in SHR/SP
    GARY ALLEN ROSENBERG; Fiscal Year: 2013
    ..hypertensive rats by using electron paramagnetic resonance (EPR) to measure ptO2 with lithium phthalocyanine (LiPc) microcrystals implanted stereotactically into the corpus callosum, and to correlate the impact of hypoxia on the ..
  16. Development of a Peptidomic Rapid Point-of-Care TB Diagnostic
    R Sam Niedbala; Fiscal Year: 2010
    ..tuberculosis (PTRP, PE-PGRS51 and LipC) that are highly immunogenic in TB subjects, but not in individuals with latent TB infection (LTBI)...
  17. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
    ..current Adip5 confidence interval, there are several credible candidate genes (Bbs4, Cpy19a1, Crabp1, Cplx3, Il18, Lipc, Nedd4), as well as dozens of genes and noncoding RNA of unknown function...
  18. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
    ..current Adip5 confidence interval, there are several credible candidate genes (Bbs4, Cpy19a1, Crabp1, Cplx3, Il18, Lipc, Nedd4), as well as dozens of genes and noncoding RNA of unknown function...
  19. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
    ..current Adip5 confidence interval, there are several credible candidate genes (Bbs4, Cpy19a1, Crabp1, Cplx3, Il18, Lipc, Nedd4), as well as dozens of genes and noncoding RNA of unknown function...
  20. Seizure-induced Neuronal Loss and Epileptogenesis in the Immature Brain
    JEFFREY JOHN EKSTRAND; Fiscal Year: 2013
    ..This project utilizes the lithium pilocarpine (LiPC) animal model of epilepsy, a well established model of chemoconvulsant status epilepticus (SE), to reexamine ..
  21. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2013
    ..current Adip5 confidence interval, there are several credible candidate genes (Bbs4, Cpy19a1, Crabp1, Cplx3, Il18, Lipc, Nedd4), as well as dozens of genes and noncoding RNA of unknown function...
  22. Advancing Genetics Through the AMDgene Consortium
    Margaret A Pericak-Vance; Fiscal Year: 2013
    ..association studies have identified and/or confirmed several additional loci of more modest individual effect (CFI, LIPC, TIMP3), with many more loci providing suggestive associations...
  23. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..We propose to use electron paramagnetic resonance (EPR) oximetry with high sensitive LiPc microcrystals as probe and specially designed EPR instrumentation, to directly measure oxygen consumption in normal,..
  24. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2007
    ..We propose to use electron paramagnetic resonance (EPR) oximetry with high sensitive LiPc microcrystals as probe and specially designed EPR instrumentation, to directly measure oxygen consumption in normal,..
  25. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2006
    ..We propose to use electron paramagnetic resonance (EPR) oximetry with high sensitive LiPc microcrystals as probe and specially designed EPR instrumentation, to directly measure oxygen consumption in normal,..
  26. SPIN TRAPPING OF FREE RADICALS W/ IN VIVO EPR DETECTION COMPARE DMPO & DEPMPO
    Ke Liu; Fiscal Year: 1999
    ..b>LiPc crystals were placed directly into the middle of the left myocardium...
  27. SPIN TRAPPING OF FREE RADICALS W/ IN VIVO EPR DETECTION COMPARE DMPO & DEPMPO
    Ke Liu; Fiscal Year: 2000
    ..b>LiPc crystals were placed directly into the middle of the left myocardium...
  28. EFFECTS OF DIETARY CHOLESTEROL ON LIPOPROTEIN METABOLISM
    RAMPRATAP KUSHWAHA; Fiscal Year: 1990
    ..lipoproteins will be correlated with each other and with activities of post-heparin plasma hepatic triglyceride (HTGL) and lipoprotein lipases (LPL) and mRNA for apo-AI and HTGL in liver and LPL in adipose tissues...
  29. MICROPUNCTURE STUDY OF KIDNEY FUNCTION
    William Arendshorst; Fiscal Year: 2000
    ....
  30. MICROPUNCTURE STUDY OF KIDNEY FUNCTION
    William Arendshorst; Fiscal Year: 2001
    ....
  31. MICROPUNCTURE STUDY OF KIDNEY FUNCTION
    William Arendshorst; Fiscal Year: 1999
    ....
  32. DEPMPO AS SPIN TRAPPING AGENT
    Ke Liu; Fiscal Year: 2000
    ..RIF-1 were also assessed for pO2 using EPR oximetry. A 1.2GHz spectrometer and LiPc crystal as the oxygen sensitive material were used...
  33. DEPMPO AS SPIN TRAPPING AGENT
    Ke Liu; Fiscal Year: 1999
    ..RIF-1 were also assessed for pO2 using EPR oximetry. A 1.2GHz spectrometer and LiPc crystal as the oxygen sensitive material were used...
  34. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    Jean MacCluer; Fiscal Year: 2005
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  35. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    Jean MacCluer; Fiscal Year: 2005
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  36. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    John Blangero; Fiscal Year: 2007
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  37. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    Jean MacCluer; Fiscal Year: 2002
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  38. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    Jean MacCluer; Fiscal Year: 2004
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  39. Mapping adiposity genes in mice
    DANIELLE REED; Fiscal Year: 2009
    ..current Adip5 confidence interval, there are several credible candidate genes (Bbs4, Cpy19a1, Crabp1, Cplx3, Il18, Lipc, Nedd4), as well as dozens of genes and noncoding RNA of unknown function...
  40. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    Jean MacCluer; Fiscal Year: 2003
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  41. GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS
    John Blangero; Fiscal Year: 2006
    ..for linkage signals for leptin and HDL2a in chromosomal regions with strong positional candidates genes (POMC and LIPC, respectively)...
  42. HETEROGENEITY OF BRAIN OXYGENATION
    Jeffrey Dunn; Fiscal Year: 2000
    For some unknown reasons LiPc crystals are not very stable under certain conditions...
  43. HETEROGENEITY OF BRAIN OXYGENATION
    Jeffrey Dunn; Fiscal Year: 1999
    For some unknown reasons LiPc crystals are not very stable under certain conditions...
  44. WORKING MEMORY AND PHONOLOGICAL REPRESENTATION
    ANTHONY WAGNER; Fiscal Year: 2001
    ..The first specific aim is to test whether brain regions subserving the phonological loop-left inferior prefrontal (LIPC) and left perisylvian (LPSC) cortices-differentially support the generation of novel phonological representations...
  45. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  46. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2004
    The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  47. Genetics, Lipids, and Responses to Exercise Training
    Amy Halverstadt; Fiscal Year: 2005
    The proposed study will assess and characterize new genetic variants in LIPH and APOL1 that may relate to plasma lipoprotein lipid levels and their changes with exercise training...
  48. WORKING MEMORY AND PHONOLOGICAL REPRESENTATION
    ANTHONY WAGNER; Fiscal Year: 2000
    ..The first specific aim is to test whether brain regions subserving the phonological loop-left inferior prefrontal (LIPC) and left perisylvian (LPSC) cortices-differentially support the generation of novel phonological representations...
  49. WORKING MEMORY AND PHONOLOGICAL REPRESENTATION
    ANTHONY WAGNER; Fiscal Year: 2002
    ..The first specific aim is to test whether brain regions subserving the phonological loop-left inferior prefrontal (LIPC) and left perisylvian (LPSC) cortices-differentially support the generation of novel phonological representations...
  50. TRANSFER OF TECHNOLOGY FOR DEVELOPMENT & APPLICATIONS OF IN VIVO EPR
    Ke Liu; Fiscal Year: 2000
    ..We are assessing regional brain pO2 using LiPc implanted at specific sites in anesthetized rats. The animal is then subjected to a graded hypoxia protocol...
  51. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2005
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  52. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2004
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  53. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  54. TRANSFER OF TECHNOLOGY FOR DEVELOPMENT & APPLICATIONS OF IN VIVO EPR
    Ke Liu; Fiscal Year: 1999
    ..We are assessing regional brain pO2 using LiPc implanted at specific sites in anesthetized rats. The animal is then subjected to a graded hypoxia protocol...
  55. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2006
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  56. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2000
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  57. OXYGEN CONCENTRATION ON REACTIVE SPECIES GENERATED DURING PHOTODYNAMIC THERAPY
    Ke Liu; Fiscal Year: 2000
    ..For example, with LiPc crystals of about 0.5mm in size, sites separated by 3mm or more could be readily followed.
  58. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2003
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  59. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2002
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  60. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2004
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  61. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2001
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  62. OXYGEN CONCENTRATION ON REACTIVE SPECIES GENERATED DURING PHOTODYNAMIC THERAPY
    Ke Liu; Fiscal Year: 1999
    ..For example, with LiPc crystals of about 0.5mm in size, sites separated by 3mm or more could be readily followed.
  63. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2004
    ..The mechanisms underlying the changes in LDL size will also be studied by measuring hepatic lipase activity, cholesteryl ester transfer protein (CETP) activity, triglyceride (TG) levels, body fat distribution ..
  64. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005
    The enzyme hepatic lipase (HL) is central to cholesterol homeostasis. HL participates in the regulation of plasma cholesterol levels, a major risk factor for atherosclerosis...
  65. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2003
    The enzyme hepatic lipase (HL) is central to cholesterol homeostasis. HL participates in the regulation of plasma cholesterol levels, a major risk factor for atherosclerosis...
  66. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2001
    The enzyme hepatic lipase (HL) is central to cholesterol homeostasis. HL participates in the regulation of plasma cholesterol levels, a major risk factor for atherosclerosis...
  67. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2002
    The enzyme hepatic lipase (HL) is central to cholesterol homeostasis. HL participates in the regulation of plasma cholesterol levels, a major risk factor for atherosclerosis...
  68. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2004
    The enzyme hepatic lipase (HL) is central to cholesterol homeostasis. HL participates in the regulation of plasma cholesterol levels, a major risk factor for atherosclerosis...
  69. Genetics of atherosclerosis in renal disease
    Muredach P Reilly; Fiscal Year: 2010
    ....
  70. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2003
    ..abstract_text> ..
  71. Mentored Patient-Oriented Research Career Development Aw
    Muredach Reilly; Fiscal Year: 2002
    ..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
  72. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2008
    ..This strengthens evaluation of risk, and application to current dietary goals. The large number of SNPs proposed for final analysis will add to the resolution and power to identify the genes that underlie CHD. ..
  73. Genetics of atherosclerosis in renal disease
    Muredach Reilly; Fiscal Year: 2009
    ....
  74. Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the Community
    Sekar Kathiresan; Fiscal Year: 2008
    ..In addition, the candidate will be well positioned to transition from conducting pathway-based investigation to genome-wide association studies for cardiovascular phenotypes. [unreadable] [unreadable]..