LIPC

Summary

Gene Symbol: LIPC
Description: lipase C, hepatic type
Alias: HDLCQ12, HTGL, LIPH, hepatic triacylglycerol lipase, Triacylglycerol lipase, hepatic lipase, lipase member C, lipase, hepatic
Species: human
Products:     LIPC

Top Publications

  1. Feitosa M, Myers R, Pankow J, Province M, Borecki I. LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion. Atherosclerosis. 2009;204:171-7 pubmed publisher
    ..b>Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage region and ..
  2. Takata M, Inazu A, Katsuda S, Miwa K, Kawashiri M, Nohara A, et al. CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia. Clin Sci (Lond). 2006;111:325-31 pubmed
    CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-..
  3. Qian K, Agrawal N, DICHEK H. Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase. Atherosclerosis. 2007;195:66-74 pubmed
    Increased expression of catalytically inactive hepatic lipase (ciHL) lowers remnants and low-density lipoproteins (LDL) and may reduce atherosclerosis in mice lacking both LDLreceptors (LDLR) and murine (m) HL...
  4. Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, Tapsell L, et al. The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study. Nutr Metab Cardiovasc Dis. 2008;18:88-95 pubmed
    b>Hepatic lipase (HL) catalyzes the hydrolysis of triglycerides and phospholipids from lipoproteins, and promotes the hepatic uptake of lipoproteins...
  5. van Acker B, Botma G, Zwinderman A, Kuivenhoven J, Dallinga Thie G, Sijbrands E, et al. High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. Atherosclerosis. 2008;200:161-7 pubmed publisher
    Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties...
  6. Botma G, van Deursen D, Vieira D, van Hoek M, Jansen H, Verhoeven A. Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression. Atherosclerosis. 2005;179:61-7 pubmed
    b>Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism...
  7. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt N, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-9 pubmed publisher
    ..The score did not improve risk discrimination but did modestly improve clinical risk reclassification for individual subjects beyond standard clinical factors. ..
  8. Wu J, Yin R, Lin W, Pan S, Yang D. Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations. Lipids. 2008;43:733-40 pubmed publisher
    ..This study was designed to compare the difference in the hepatic lipase gene (LIPC) -514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and ..
  9. Ruixing Y, Jinzhen W, Weixiong L, Yuming C, Dezhai Y, Shangling P. The environmental and genetic evidence for the association of hyperlipidemia and hypertension. J Hypertens. 2009;27:251-8 pubmed publisher
    ..2, apolipoprotein (apo) A-I, apoB, apoE, cholesteryl ester transfer protein, G-protein beta-3 subunit, hepatic lipase, lipoprotein lipase, microsomal triglyceride transfer protein, regulator of G-protein signaling 2, and sterol ..

More Information

Publications68

  1. Yu Y, Reynolds R, Fagerness J, Rosner B, Daly M, Seddon J. Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:4663-70 pubmed publisher
    ..There is little information about which genes influence drusen accumulation. Discovery of genetic variants associated with drusen may lead to prevention and treatments of AMD in its early stages...
  2. Seddon J, Reynolds R, Rosner B. Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Mol Vis. 2010;16:2412-24 pubmed
    A novel locus in the hepatic lipase (LIPC) gene was found to be significantly related to advanced age-related macular degeneration (AMD) in our genome-wide association study...
  3. Reynolds R, Rosner B, Seddon J. Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Ophthalmology. 2010;117:1989-95 pubmed publisher
    A genetic variant in the high-density lipoprotein (HDL) cholesterol pathway, hepatic lipase (LIPC), was discovered to be associated with advanced age-related macular degeneration (AMD) in a genome-wide association study...
  4. Grarup N, Andreasen C, Andersen M, Albrechtsen A, Sandbaek A, Lauritzen T, et al. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. J Clin Endocrinol Metab. 2008;93:2294-9 pubmed publisher
    b>Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein...
  5. Hegele R, Little J, Connelly P. Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency. Biochem Biophys Res Commun. 1991;179:78-84 pubmed
    In a kindred with three hyperlipidemic subjects who had premature atherosclerosis and complete deficiency of hepatic lipase activity, we had previously identified a novel structural hepatic lipase gene variant...
  6. Zhu H, Taylor J, Bennett D, Younkin S, Estus S. Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease. Neurobiol Aging. 2008;29:793-4 pubmed
    Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD)...
  7. Cai S, Wong D, Chen S, Chan L. Structure of the human hepatic triglyceride lipase gene. Biochemistry. 1989;28:8966-71 pubmed
    ..By primer extension, hepatic lipase mRNA initiates at an adenine 77 bases upstream of the translation initiation site...
  8. Brunzell J, Zambon A, Deeb S. The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype. Biochim Biophys Acta. 2012;1821:365-72 pubmed publisher
    Increased or decreased hepatic lipase (HL) activity has been associated with coronary artery disease (CAD)...
  9. Jimenez Gomez Y, Perez Jimenez F, Marin C, Gomez P, Moreno R, Delgado J, et al. The -250G/A polymorphism in the hepatic lipase gene promoter influences the postprandial lipemic response in healthy men. Nutr Metab Cardiovasc Dis. 2008;18:173-81 pubmed
    The -250G/A promoter polymorphism of the hepatic lipase gene has been associated with changes in the activity of the enzyme...
  10. Soyal S, Sandhofer A, Hahne P, Oberkofler H, Felder T, Iglseder B, et al. Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis. Atherosclerosis. 2011;216:374-80 pubmed publisher
    HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other...
  11. Kashani Farid M, Azizi F, Hedayati M, Daneshpour M, Shamshiri A, Siassi F. Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. Lipids Health Dis. 2010;9:96 pubmed publisher
    ..Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C...
  12. Wood K, Fullerton M, El Sohemy A, Bakovic M. Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults. Appl Physiol Nutr Metab. 2008;33:761-8 pubmed publisher
    The purpose of this study was to assess the individual and interactive effects between hepatic lipase (LIPC; C-514T, G-250A) and apolipoprotein E (APOE) (E2, E3, E4) gene polymorphisms on levels of plasma lipoprotein cholesterol and ..
  13. Ko Y, Hsu L, Hsu K, Ko Y, Lee Y. The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese. Atherosclerosis. 2004;172:135-42 pubmed
    b>Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and plays a key role in reverse cholesterol transport...
  14. Jansen H, Verhoeven A, Sijbrands E. Hepatic lipase: a pro- or anti-atherogenic protein?. J Lipid Res. 2002;43:1352-62 pubmed
    b>Hepatic lipase (HL) plays a role in the metabolism of pro- and anti-atherogenic lipoproteins affecting their plasma level and composition. However, there is controversy regarding whether HL accelerates or retards atherosclerosis...
  15. Neale B, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400 pubmed publisher
    ..Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258)...
  16. Zambon A, Deeb S, Pauletto P, Crepaldi G, Brunzell J. Hepatic lipase: a marker for cardiovascular disease risk and response to therapy. Curr Opin Lipidol. 2003;14:179-89 pubmed
    b>Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties...
  17. Valdivielso P, Ariza M, de la Vega Román C, González Alegre T, Rioja J, Ulzurrun E, et al. Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients. J Diabetes Complications. 2008;22:273-7 pubmed publisher
    This study aimed to investigate the association between a polymorphism in the hepatic lipase (LIPC) gene promoter and the presence of peripheral arterial disease (PAD) in persons with type 2 diabetes...
  18. Chamberlain A, Folsom A, Schreiner P, Boerwinkle E, Ballantyne C. Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis. 2008;200:322-8 pubmed publisher
    ..and LDL-c levels, as well as the associations between the cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC C-514T), and lipoprotein lipase (LPL Ser447Stop) genes and HDL-c levels are significantly modified by ..
  19. Ameis D, Stahnke G, Kobayashi J, McLean J, Lee G, Buscher M, et al. Isolation and characterization of the human hepatic lipase gene. J Biol Chem. 1990;265:6552-5 pubmed
    ..and cosmid genomic clones were isolated spanning an area of approximately 60 kilobases that contains the human hepatic lipase (HL) gene. It is composed of 9 exons spanning approximately 35 kilobases of DNA...
  20. Isaacs A, Aulchenko Y, Hofman A, Sijbrands E, Sayed Tabatabaei F, Klungel O, et al. Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 2007;92:2680-7 pubmed
    Polymorphisms in the hepatic lipase (LIPC -514C > T) and cholesteryl ester transfer protein (CETP I405V) genes affect high-density lipoprotein cholesterol (HDL-c) levels, but their relationship with cardiovascular disease and their ..
  21. Wei M, Lu Y, Li P. [Association of the hepatic lipase gene -250G/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:219-22 pubmed publisher
    To investigate the association of hepatic lipase -250G/A gene promoter polymorphism with type 2 diabetes mellitus combining with coronary heart disease...
  22. Fan Y, Raitakari O, Kahonen M, Hutri Kähönen N, Juonala M, Marniemi J, et al. Hepatic lipase promoter C-480T polymorphism is associated with serum lipids levels, but not subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study. Clin Genet. 2009;76:46-53 pubmed publisher
    The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease...
  23. Bertolini S, Pisciotta L, Di Scala L, Langheim S, Bellocchio A, Masturzo P, et al. Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia. Atherosclerosis. 2004;174:57-65 pubmed
    ..These findings show that several common genetic variants influence the lipid phenotype and the CAD risk in FH heterozygotes. ..
  24. Ruel I, Couture P, Gagne C, Deshaies Y, Simard J, Hegele R, et al. Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians. J Lipid Res. 2003;44:1508-14 pubmed
    Individuals with hepatic lipase (HL) deficiency are often characterized by elevated levels of triglycerides (TGs) and cholesterol...
  25. Andersen R, Wittrup H, Tybjaerg Hansen A, Steffensen R, Schnohr P, Nordestgaard B. Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol. 2003;41:1972-82 pubmed
    We investigated associations between single nucleotide polymorphisms (SNPs) in the hepatic lipase promoter, levels of high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  26. Baroni M, Berni A, Romeo S, Arca M, Tesorio T, Sorropago G, et al. Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established . BMC Med Genet. 2003;4:8 pubmed
    ..genetic variables were: apolipoprotein E (Apo E), Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and the hepatic lipase (LIPC) genes...
  27. Zacharova J, Todorova B, Chiasson J, Laakso M. The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. J Intern Med. 2005;257:185-93 pubmed
    ..b>Hepatic lipase gene encoding a lipolytic enzyme participating in remodelling of plasma lipoproteins and formation of serum ..
  28. Juo S, Han Z, Smith J, Colangelo L, Liu K. Promoter polymorphisms of hepatic lipase gene influence HDL(2) but not HDL(3) in African American men: CARDIA study. J Lipid Res. 2001;42:258-64 pubmed
    b>Hepatic lipase encoded by the hepatic lipase gene (LIPC) is involved in the metabolism of several lipoproteins...
  29. Masana L, Febrer G, Cavanna J, Baroni M, Marz W, Hoffmann M, et al. Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. Clin Sci (Lond). 2001;100:183-90 pubmed
    Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary ..
  30. Fiegenbaum M, da Silveira F, Van der Sand C, Van der Sand L, Ferreira M, Pires R, et al. Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects. Clin Chim Acta. 2005;362:182-8 pubmed
    ..Polymorphisms in apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC), proteins with major roles in lipid metabolism and homeostasis have been shown associated with lipid-..
  31. Eller P, Schgoer W, Mueller T, Tancevski I, Wehinger A, Ulmer H, et al. Hepatic lipase polymorphism and increased risk of peripheral arterial disease. J Intern Med. 2005;258:344-8 pubmed
    b>Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties...
  32. Santamarina Fojo S, Haudenschild C, Amar M. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol. 1998;9:211-9 pubmed
    ..role in the hydrolysis of lipoprotein triglycerides and phospholipids, recent studies have implicated hepatic lipase in other aspects of cellular lipid and/or lipoprotein metabolism and atherosclerosis...
  33. Gonzalez Navarro H, Nong Z, Freeman L, Bensadoun A, Peterson K, Santamarina Fojo S. Identification of mouse and human macrophages as a site of synthesis of hepatic lipase. J Lipid Res. 2002;43:671-5 pubmed
    b>Hepatic lipase (HL) is synthesized by the liver and is also present in steroidogenic tissues...
  34. Stancakova A, Baldaufová L, Javorsky M, Kozarova M, Salagovic J, Tkac I. Effect of gene polymorphisms on lipoprotein levels in patients with dyslipidemia of metabolic syndrome. Physiol Res. 2006;55:483-90 pubmed
    ..ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A polymorphism and apolipoprotein C-III (APOC3) SstI gene polymorphism on lipid levels in ..
  35. Wang H, Jiang M, Qiu J. Quantitative assessment of the effect of hepatic lipase gene polymorphism on the risk of coronary heart disease. Arch Med Res. 2010;41:383-90 pubmed publisher
    The human hepatic lipase (LIPC) is a glycoprotein member of the lipase superfamily that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its enzyme function as a key factor in lipoprotein ..
  36. Ordovas J, Corella D, Demissie S, Cupples L, Couture P, Coltell O, et al. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation. 2002;106:2315-21 pubmed
    ..b>Hepatic lipase (HL) is a key determinant of HDL metabolism...
  37. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..In addition, our data revealed strong association signals with alleles at two loci (LIPC, P = 1.3 x 10(-7); CETP, P = 7...
  38. Meng L, Ruixing Y, Yiyang L, Xingjiang L, Kela L, Wanying L, et al. Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010;9:28 pubmed publisher
    The association between -250G>A polymorphism in the promoter region of the hepatic lipase gene (LIPC) and plasma high-density lipoprotein cholesterol (HDL-C) concentration is contradictory in diverse ethnics...
  39. Chasman D, Pare G, Mora S, Hopewell J, Peloso G, Clarke R, et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 2009;5:e1000730 pubmed publisher
    ..addition, genetic determinants of total IDL and total VLDL concentration were found at many loci, most strongly at LIPC (15q22.1) and APOC-APOE complex (19q13.32), respectively...
  40. Yu Y, Bhangale T, Fagerness J, Ripke S, Thorleifsson G, Tan P, et al. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011;20:3699-709 pubmed publisher
    ..rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), LIPC (rs10468017), TIMP3 (rs9621532) and CETP (rs3764261) were confirmed with genome-wide significant signals in this ..
  41. Laws S, Eckart K, Friedrich P, Eisele T, Kurz A, Forstl H, et al. No association of lipase C polymorphisms with Alzheimer's disease. Neurobiol Aging. 2010;31:2192-3 pubmed publisher
    b>Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism...
  42. de Andrade F, Silveira F, Arsand M, Antunes A, Torres M, Zago A, et al. Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population. Clin Genet. 2004;65:390-5 pubmed
    b>Hepatic lipase (HL) is a glycoprotein that plays a major role in remodeling high-density lipoprotein (HDL)...
  43. Todorova B, Kubaszek A, Pihlajamaki J, Lindström J, Eriksson J, Valle T, et al. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab. 2004;89:2019-23 pubmed
    ..We investigated whether the G-250A polymorphism of the hepatic lipase gene (LIPC) predicts the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish ..
  44. Isaacs A, Sayed Tabatabaei F, Njajou O, Witteman J, van Duijn C. The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J Clin Endocrinol Metab. 2004;89:3858-63 pubmed
    Investigations of the -514 C-->T single nucleotide polymorphism (SNP) in the hepatic lipase (HL) gene promoter region (LIPC) have yielded contradictory results regarding its association with changes in plasma lipids...
  45. Rufibach L, Duncan S, Battle M, Deeb S. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. J Lipid Res. 2006;47:1463-77 pubmed
    b>Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease...
  46. Zhao S, Xie X, Nie S. The -250G-->A polymorphism in the human hepatic lipase gene promoter affects blood lipids in Chinese. Clin Chim Acta. 2006;365:149-52 pubmed
    Human hepatic lipase (HL) is a glycoprotein that catalyzes the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins...
  47. Teran Garcia M, Santoro N, Rankinen T, Bergeron J, Rice T, Leon A, et al. Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study. Diabetes. 2005;54:2251-5 pubmed
    We investigated the associations between the hepatic lipase gene (LIPC) -514C>T polymorphism and lipases, lipoproteins, and insulin sensitivity (Si) responses to exercise training...
  48. Kimura H, Miyazaki R, Imura T, Masunaga S, Suzuki S, Gejyo F, et al. Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels. Kidney Int. 2003;64:1829-37 pubmed
    ..b>Hepatic lipase (HL), together with cholesteryl ester transfer protein (CETP), may not only promote reverse cholesterol ..
  49. Tetik Vardarlı A, Harman E, Bozok Cetintaş V, Kayikcioglu M, Vardarli E, Zengi A, et al. Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia. Anatol J Cardiol. 2017;17:313-321 pubmed publisher
    ..The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662),..
  50. Harding C, Kinsella R, Palmer L, Skaar E, Feldman M. Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence. PLoS Pathog. 2016;12:e1005391 pubmed publisher
    ..analyses, we show that Acinetobacter employs its T2SS to export multiple substrates, including the lipases LipA and LipH as well as the protease CpaA...
  51. Verdier C, Ruidavets J, Bongard V, Taraszkiewicz D, Martinez L, Elbaz M, et al. Association of hepatic lipase -514T allele with coronary artery disease and ankle-brachial index, dependence on the lipoprotein phenotype: the GENES study. PLoS ONE. 2013;8:e67805 pubmed publisher
    Relationship between hepatic lipase (LIPC) polymorphism and coronary artery disease (CAD) has often led to contradictory results...
  52. Kraja A, Vaidya D, Pankow J, Goodarzi M, Assimes T, Kullo I, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011;60:1329-39 pubmed publisher
    ..Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were further tested for their association with individual ..
  53. Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C. Sex differences in environmental and genetic factors for hypertension. Am J Med. 2008;121:811-9 pubmed publisher
    ..enzyme, adrenergic receptor beta(3), aldehyde dehydrogenase 2, calpastatin, connexin 37, hepatic lipase, lipoprotein lipase, peroxisome proliferator-activated receptor gamma, thyrotropin-releasing hormone receptor, ..
  54. Souverein O, Jukema J, Boekholdt S, Zwinderman A, Tanck M. Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. Eur J Hum Genet. 2005;13:445-51 pubmed
    ..in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). The gene variants APOA1 G(-75)A (P=0.04) and LPL Asn291Ser (P=0...
  55. Vincent S, Planells R, Defoort C, Bernard M, Gerber M, Prudhomme J, et al. Genetic polymorphisms and lipoprotein responses to diets. Proc Nutr Soc. 2002;61:427-34 pubmed
    ..MTP), fatty acid-binding protein (FABP), cholesteryl ester transfer protein (CETP), lipoprotein lipase and hepatic lipase, have been identified and linked to variable responses to diets...
  56. Buonuomo P, Rabacchi C, Macchiaiolo M, Trenti C, Fasano T, Tarugi P, et al. Incidental finding of severe hypertriglyceridemia in children. Role of multiple rare variants in genes affecting plasma triglyceride. J Clin Lipidol. 2017;11:1329-1337.e3 pubmed publisher
    ..a less severe HyperTG was found to be heterozygous for a frameshift variant in LIPC resulting in a truncated Hepatic Lipase. In addition, 1 of the patients with LPL deficiency and the patient with APOA-V deficiency were also ..
  57. López Ríos L, Novoa F, Chirino R, Varillas F, Boronat Cortés M, Wägner A. Interaction between cholesteryl ester transfer protein and hepatic lipase encoding genes and the risk of type 2 diabetes: results from the Telde study. PLoS ONE. 2011;6:e27208 pubmed publisher
    ..The Taq1B polymorphism in CETP (B1 and B2 alleles) (rs708272) and the G-250A polymorphism in LIPC (rs2070895) are associated with changes in enzyme activity and lipid concentrations...
  58. Tanahashi K, Sugiura K, Takeichi T, Takama H, Shinkuma S, Shimizu H, et al. Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood. J Eur Acad Dermatol Venereol. 2013;27:1182-4 pubmed publisher
    Mutations in LIPH are a cause of autosomal recessive woolly hair (ARWH). Homozygous c.736T>A (p.Cys246Ser), and compound heterozygous c.736T>A and c.742C>A (p...
  59. Hokanson J, Cheng S, Snell Bergeon J, Fijal B, Grow M, Hung C, et al. A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes. Diabetes. 2002;51:1208-13 pubmed
    ..The hepatic lipase gene promoter polymorphism (LIPC-480C>T) is a common variant affecting lipid metabolism...