LIN28A

Summary

Gene Symbol: LIN28A
Description: lin-28 homolog A
Alias: CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, protein lin-28 homolog A, RNA-binding protein LIN-28, zinc finger CCHC domain-containing protein 1, zinc finger, CCHC domain containing 1
Species: human
Products:     LIN28A

Top Publications

  1. Yang X, Lin X, Zhong X, Kaur S, Li N, Liang S, et al. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010;70:9463-72 pubmed publisher
    ..Using cDNA microarray analysis, we identified that the expression of the Caenorhabditis elegans lin-28 homologue (LIN28) was positively correlated with the percentage of ALDH1+ tumor cells; this was further validated in an independent ..
  2. Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, et al. Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 2012;22:524-35 pubmed publisher
    ..repressed in acute leukemia, by blocking miR-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis...
  3. Thornton J, Chang H, Piskounova E, Gregory R. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012;18:1875-85 pubmed publisher
    The pluripotency factor Lin28 recruits a 3' terminal uridylyl transferase (TUTase) to selectively block let-7 microRNA biogenesis in undifferentiated cells...
  4. Dangi Garimella S, Yun J, Eves E, Newman M, Erkeland S, Hammond S, et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009;28:347-58 pubmed publisher
    ..The mechanism involves inhibition of MAPK, leading to decreased transcription of LIN28 by Myc. Suppression of LIN28 enables enhanced let-7 processing in breast cancer cells...
  5. Pan L, Gong Z, Zhong Z, Dong Z, Liu Q, Le Y, et al. Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells. Mol Cell Biochem. 2011;355:257-63 pubmed publisher
    ..The results presented here demonstrate that induction of Lin-28 could mediate repression of let-7 family members, promote cell cycle progression and suppress cell proliferation. ..
  6. Gillis A, Stoop H, Biermann K, van Gurp R, Swartzman E, Cribbes S, et al. Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl. 2011;34:e160-74 pubmed publisher
    OCT3/4, NANOG, SOX2 and, most recently, LIN28 have been identified as key regulators of pluripotency in mammalian embryonic and induced stem cells, and are proven to be crucial for generation of the mouse germ-cell lineage...
  7. Cai W, Wei T, Luo Q, Wu Q, Liu Q, Yang M, et al. The Wnt-?-catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion. J Cell Sci. 2013;126:2877-89 pubmed publisher
    ..Furthermore, we identified Lin28, a negative let-7 biogenesis regulator, as a novel direct downstream target of the Wnt-?-catenin pathway...
  8. Moss E, Tang L. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev Biol. 2003;258:432-42 pubmed
    ..elegans lin-4 and let-7 microRNAs, suggesting that microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals. ..
  9. Viswanathan S, Powers J, Einhorn W, Hoshida Y, Ng T, Toffanin S, et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009;41:843-8 pubmed publisher
    ..However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The RNA-binding proteins LIN28 and LIN28B block let-7 precursors from being processed to mature miRNAs, suggesting that their overexpression ..

More Information

Publications86

  1. Jin J, Jing W, Lei X, Feng C, Peng S, Boris Lawrie K, et al. Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes. Nucleic Acids Res. 2011;39:3724-34 pubmed publisher
    The stem cell protein Lin28 functions to inhibit the biogenesis of a group of miRNAs but also stimulates the expression of a subset of mRNAs at the post-transcriptional level, the underlying mechanism of which is not yet understood...
  2. Qiu C, Ma Y, Wang J, Peng S, Huang Y. Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Res. 2010;38:1240-8 pubmed publisher
    b>Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs...
  3. West J, Viswanathan S, Yabuuchi A, Cunniff K, Takeuchi A, Park I, et al. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature. 2009;460:909-13 pubmed publisher
    ..RNAs to screen candidate genes for effects on the development of Stella(+) cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing, is essential for proper PGC development...
  4. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  5. Wu L, Belasco J. Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. Mol Cell Biol. 2005;25:9198-208 pubmed
    ..The decrease in the mRNA concentration is achieved by a posttranscriptional mechanism that is independent of the inhibitory effect on translation. ..
  6. Feng C, Neumeister V, Ma W, Xu J, Lu L, Bordeaux J, et al. Lin28 regulates HER2 and promotes malignancy through multiple mechanisms. Cell Cycle. 2012;11:2486-94 pubmed publisher
    The RNA binding protein Lin28 and its paralog Lin28B are associated with advanced human malignancies. Blocking the biogenesis of let-7 miRNA, a tumor suppressor, by Lin28/Lin28B has been thought to underlie their roles in cancer...
  7. Richards M, Tan S, Tan J, Chan W, Bongso A. The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells. 2004;22:51-64 pubmed
    ..Of particular interest was the downregulation of DNMT3B and LIN28 mRNAs during ES cell differentiation...
  8. Lightfoot H, Bugaut A, Armisen J, Lehrbach N, Miska E, Balasubramanian S. A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing. Biochemistry. 2011;50:7514-21 pubmed publisher
    Several recent studies have provided evidence that LIN28, a cytoplasmic RNA-binding protein, inhibits the biogenesis of members of the let-7 microRNA family at the Dicer step in both mammals and Caenorhabditis elegans...
  9. Wilbert M, Huelga S, Kapeli K, Stark T, Liang T, Chen S, et al. LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Mol Cell. 2012;48:195-206 pubmed publisher
    b>LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis...
  10. Piskounova E, Viswanathan S, Janas M, LaPierre R, Daley G, Sliz P, et al. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008;283:21310-4 pubmed publisher
    The developmentally regulated RNA-binding protein Lin28 blocks processing of let-7 family microRNAs (miRNAs) in embryonic cells. The molecular basis for this selective miRNA processing block is unknown...
  11. Lv K, Liu L, Wang L, Yu J, Liu X, Cheng Y, et al. Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells. PLoS ONE. 2012;7:e40008 pubmed publisher
    Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to tumor relapse after chemotherapy; however, the relationship between Lin28 and chemoresistance remained unknown...
  12. Piskounova E, Polytarchou C, Thornton J, LaPierre R, Pothoulakis C, Hagan J, et al. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011;147:1066-79 pubmed publisher
    b>Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block processing by Dicer in the cell cytoplasm...
  13. Balzer E, Moss E. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules. RNA Biol. 2007;4:16-25 pubmed
    b>Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA-binding motifs: a cold shock domain and a pair of retroviral-type CCHC zinc fingers. In the nematode C. elegans, it is a regulator of developmental timing...
  14. Peng S, Chen L, Lei X, Yang L, Lin H, Carmichael G, et al. Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells. 2011;29:496-504 pubmed publisher
    b>Lin28 inhibits the expression of let-7 microRNAs but also exhibits let-7-independent functions. Using immunoprecipitation and deep sequencing, we show here that Lin28 preferentially associates with a small subset of cellular mRNAs...
  15. Zhong X, Li N, Liang S, Huang Q, Coukos G, Zhang L. Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem. 2010;285:41961-71 pubmed publisher
    b>LIN28 (a homologue of the Caenorhabditis elegans lin-28 gene) is an evolutionarily conserved RNA-binding protein and a master regulator controlling the pluripotency of embryonic stem cells...
  16. Darr H, Benvenisty N. Genetic analysis of the role of the reprogramming gene LIN-28 in human embryonic stem cells. Stem Cells. 2009;27:352-62 pubmed publisher
    ..Thus, LIN-28 does not seem to be involved in the self-renewal of HESCs, but rather seems to be involved in their decision to switch from self-renewal to differentiation. ..
  17. Hafner M, Max K, Bandaru P, Morozov P, Gerstberger S, Brown M, et al. Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition. RNA. 2013;19:613-26 pubmed publisher
    Human LIN28A and LIN28B are RNA-binding proteins (RBPs) conserved in animals with important roles during development and stem cell reprogramming...
  18. Xu C, Shen J, Xie S, Jiang Z, Huang L, Wang L. Positive expression of Lin28 is correlated with poor survival in gastric carcinoma. Med Oncol. 2013;30:382 pubmed publisher
    The purpose of this study was to investigate the expression of Lin28 in gastric carcinoma and to assess its clinical significance...
  19. Heo I, Joo C, Cho J, Ha M, Han J, Kim V. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008;32:276-84 pubmed publisher
    ..Here, we report the RNA-binding proteins, Lin28a and Lin28b, as posttranscriptional repressors of let-7 miRNA biogenesis...
  20. Cao D, Liu A, Wang F, Allan R, Mei K, Peng Y, et al. RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011;24:288-96 pubmed publisher
    b>LIN28 has been shown to have an important role in primordial germ cell development and malignant transformation of germ cells in mouse...
  21. Loughlin F, Gebert L, Towbin H, Brunschweiger A, Hall J, Allain F. Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28. Nat Struct Mol Biol. 2011;19:84-9 pubmed publisher
    b>Lin28 inhibits the biogenesis of let-7 miRNAs through a direct interaction with the terminal loop of pre-let-7. This interaction requires the zinc-knuckle domains of Lin28...
  22. Hamano R, Miyata H, Yamasaki M, Sugimura K, Tanaka K, Kurokawa Y, et al. High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer. Br J Cancer. 2012;106:1415-23 pubmed publisher
    b>Lin28 is a negative regulator of the tumour suppressor microRNA, let-7, suggesting its role in tumourigenesis. However, the clinical significance of Lin28 expression in oesophageal cancer has not been elucidated...
  23. Li X, Zhang J, Gao L, McClellan S, Finan M, Butler T, et al. MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ. 2012;19:378-86 pubmed publisher
    ..the existence of a reciprocal regulatory loop between the family of let-7 miRNAs and an RNA-binding protein, Lin28, both of which have been documented for their important roles during cell differentiation...
  24. Heo I, Joo C, Kim Y, Ha M, Yoon M, Cho J, et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell. 2009;138:696-708 pubmed publisher
    As key regulators in cellular functions, microRNAs (miRNAs) themselves need to be tightly controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by inducing uridylation of let-7 precursor (pre-let-7)...
  25. Iliopoulos D, Hirsch H, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell. 2009;139:693-706 pubmed publisher
    ..Src activation triggers an inflammatory response mediated by NF-kappaB that directly activates Lin28 transcription and rapidly reduces let-7 microRNA levels...
  26. Peng S, Maihle N, Huang Y. Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene. 2010;29:2153-9 pubmed publisher
    b>Lin28 and Oct4 are highly expressed in human embryonic stem (ES) cells and, along with two other stem cell marker proteins (Nanog and Sox2), together can convert human somatic cells to pluripotency...
  27. Närvä E, Rahkonen N, Emani M, Lund R, Pursiheimo J, Nästi J, et al. RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Stem Cells. 2012;30:452-60 pubmed publisher
    ..We show that L1TD1 colocalizes and interacts with LIN28 via RNA and directly with RNA helicase A (RHA)...
  28. Sakurai M, Miki Y, Masuda M, Hata S, Shibahara Y, Hirakawa H, et al. LIN28: a regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. J Steroid Biochem Mol Biol. 2012;131:101-6 pubmed publisher
    A tumor-suppressor gene, let-7 microRNA (miRNA) family, is often inactivated in various human malignancies. LIN28 is a RNA-binding protein that has been well characterized for regulation of let-7 maturation in undifferentiated embryonic ..
  29. Faria A, Sbiera S, Ribeiro T, Soares I, Mariani B, Freire D, et al. Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer. Clin Endocrinol (Oxf). 2015;82:481-8 pubmed publisher
    ..b>LIN28A and LIN28B gene expression was analysed in 59 ACTs (31 adenomas and 28 carcinomas) and copy number variation in 39 ..
  30. Bai Y, Feng M, Liu S, Wei H, Li L, Zhang X, et al. Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. Int J Mol Med. 2016;38:423-32 pubmed publisher
    ..Our findings indicated that the mSSCs (l) expressed high levels of the transcription factors, Lin28 and Prmt5, and the epigenetic factors, Tet3, Parp1, Max, Tert and Trf1, in comparison with the mESCs, with the ..
  31. Liu X, Chen M, Li L, Gong L, Zhou H, Gao D. Extracellular Signal-regulated Kinases (ERKs) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation. J Biol Chem. 2017;292:3970-3976 pubmed publisher
    b>Lin28a, originally discovered in the nematode Caenorhabditis elegans and highly conserved across species, is a well characterized regulator of let-7 microRNA (miRNA) and is implicated in cell proliferation and pluripotency ..
  32. Megges M, Oreffo R, Adjaye J. Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells. Stem Cell Res. 2016;16:128-32 pubmed publisher
    ..were reprogrammed to induced pluripotent stem cells using episomal plasmid-based expression of OCT4, SOX2, NANOG, LIN28, SV40LT, KLF4 and c-MYC and supplemented with the following pathway inhibitors - TGF? receptor inhibitor (A-83-01),..
  33. Ortiz Cabrera N, Riveiro Alvarez R, Lopez Martinez M, Pérez Segura P, Aragón Gómez I, Trujillo Tiebas M, et al. Clinical Exome Sequencing Reveals MKRN3 Pathogenic Variants in Familial and Nonfamilial Idiopathic Central Precocious Puberty. Horm Res Paediatr. 2017;87:88-94 pubmed publisher
    ..75 years of age. We did not find any pathogenic variants in KISS1, KISS1R, LIN28, GNRH, GNRHR, TACR3, and TAC3...
  34. Blassl C, Kuhlmann J, Webers A, Wimberger P, Fehm T, Neubauer H. Gene expression profiling of single circulating tumor cells in ovarian cancer - Establishment of a multi-marker gene panel. Mol Oncol. 2016;10:1030-42 pubmed publisher
    ..N-cadherin, Vimentin, Snai1/2, CD117, CD146, CD49f) and stem cell (CD44, ALDH1A1, Nanog, SOX2, Notch1/4, Oct4, Lin28) associated transcripts...
  35. Matz P, Adjaye J. Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells. Stem Cell Res. 2015;15:581-3 pubmed publisher
    ..the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro...
  36. Park Y, Nemeño J, Choi N, Lee J, Ko K, Choi S, et al. Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts. Biol Chem. 2016;397:249-55 pubmed publisher
    ..in the maintenance of embryonic stem cells and is one of the reprogramming factors along with Oct4, Sox2, and Lin28. Nanog expression has been detected in different types of tumors, and its expression is a poor prognosis for ..
  37. Tangprasittipap A, Jittorntrum B, Wongkummool W, Kitiyanant N, Tubsuwan A. Generation of induced pluripotent stem cells from peripheral blood CD34+ hematopoietic progenitors of a 31year old healthy woman. Stem Cell Res. 2017;20:91-93 pubmed publisher
    ..Episomal vectors carrying reprogramming factors OCT4, SOX2, KLF4, L-MYC, LIN28, and shRNA of TP53 and EBNA-1 were delivered using electroporation...
  38. Xiong K, Zhou Y, Hyttel P, Bolund L, Freude K, Luo Y. Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM). Stem Cell Res. 2016;17:665-669 pubmed publisher
    ..Expression of pluripotency genes (OCT4, SOX2, LIN28A, NANOG, GDF3, SSEA4, and TRA-1-60), differentiation potential to all three germ layers, and normal karyotypes are ..
  39. Park J, Park B, Kang Y, Byun S, Hwang S, Kim D, et al. Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells. Cell Biochem Funct. 2017;35:497-509 pubmed publisher
    ..The Lin28a gene encodes an RNA-binding protein that plays a role in regulating stem cell activity, including self-renewal and ..
  40. Deisch J, Raisanen J, Rakheja D. Immunohistochemical expression of embryonic stem cell markers in malignant rhabdoid tumors. Pediatr Dev Pathol. 2011;14:353-9 pubmed publisher
    ..cells, we hypothesized that the human malignant rhabdoid tumors may express pluripotency genes such as SALL4 , LIN28 , OCT3 and OCT4 (OCT3/4) , NANOG , and TCL1 ...
  41. You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, et al. Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene. 2014;33:449-60 pubmed publisher
    ..Here, we were interested in knowing whether the oncogene Lin28A and its homolog Lin28B are involved in the hepatocarcinogenesis mediated by HBx...
  42. Wang L, Yuan C, Lv K, Xie S, Fu P, Liu X, et al. Lin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling. PLoS ONE. 2013;8:e67373 pubmed publisher
    Resistance to radiation therapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to breast tumorigenesis; however, the relationship between Lin28 and radioresistance remains unknown...
  43. Tu H, Schwitalla S, Qian Z, LaPier G, Yermalovich A, Ku Y, et al. LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015;29:1074-86 pubmed publisher
    Colorectal cancer (CRC) remains a major contributor to cancer-related mortality. LIN28A and LIN28B are highly related RNA-binding protein paralogs that regulate biogenesis of let-7 microRNAs and influence development, metabolism, tissue ..
  44. Qiu J, Huang P, You J, Zou R, Wang L, Hong J, et al. LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy. Chin J Cancer. 2012;31:223-32 pubmed publisher
    Stem cell marker LIN28, related closely with SOX2 and OCT4, has been studied as a biomarker for the maintainance of pluripotent cells in several malignancies...
  45. Parisi S, Passaro F, Russo L, Musto A, Navarra A, Romano S, et al. Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events. FASEB J. 2017;31:1046-1058 pubmed publisher
    b>Lin28 RNA-binding proteins play important roles in pluripotent stem cells, but the regulation of their expression and the mechanisms underlying their functions are still not definitively understood...
  46. Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, et al. Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development. 2017;144:63-73 pubmed publisher
    ..Furthermore, we found that the heterochronic gene Lin28a could act as a regulator of the metabolic changes observed during CB...
  47. Chandrasekaran S, Zhang J, Sun Z, Zhang L, Ross C, Huang Y, et al. Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. Cell Rep. 2017;21:2965-2977 pubmed publisher
    ..The model also predicts that the pluripotency factor Lin28 regulates this one-carbon metabolic pathway, which we validate using metabolomics data from Lin28-deficient cells...
  48. Schröter F, Sleegers K, Cuyvers E, Bohndorf M, Wruck W, Van Broeckhoven C, et al. Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Stem Cell Res. 2016;16:113-5 pubmed publisher
    ..integration-free induced pluripotent stem (iPS) cells employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC...
  49. Yang C, Chang K, Dang J, Rana T. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity. Sci Rep. 2016;6:26899 pubmed publisher
    ..Our data reveal novel roles for Pcgf6 in directly regulating Oct4, Nanog, Sox2, and Lin28 expression to maintain ESC identity.
  50. Wang L, Wang Y, Zhang D, Fang X, Sun P, Xue H. Let-7a mimic attenuates CCL18 induced breast cancer cell metastasis through Lin 28 pathway. Biomed Pharmacother. 2016;78:301-307 pubmed publisher
    ..Furthermore, the cell cycle was dramatically blocked at the G2/M phase. The luciferase reporter identified Lin28 as the direct binding target of let-7a in both breast cancer cell lines...
  51. Sharma N, Nanta R, Sharma J, Gunewardena S, Singh K, Shankar S, et al. PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth. Oncotarget. 2015;6:32039-60 pubmed publisher
    ..NVP-LDE-225 co-operated with NVP-BEZ-235 to inhibit Lin28/Let7a/Kras axis in pancreatic CSCs...
  52. Kim B, Ha M, Loeff L, Chang H, Simanshu D, Li S, et al. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. EMBO J. 2015;34:1801-15 pubmed publisher
    ..which human TUT7 (also known as ZCCHC6) recognizes and uridylates precursor miRNAs (pre-miRNAs) in the absence of Lin28. We find that the overhang of a pre-miRNA is the key structural element that is recognized by TUT7 and its ..
  53. Tummala R, Nadiminty N, Lou W, Evans C, Gao A. Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation. Prostate. 2016;76:445-55 pubmed publisher
    ..Sensitivity of LNCaP cells overexpressing Lin28 (LN-Lin28) to enzalutamide, abiraterone, or bicalutamide was compared to that of control LN-neo cells using cell ..
  54. Kusakabe K, Kohno S, Inoue A, Seno T, Yonezawa S, Moritani K, et al. Combined morphological, immunohistochemical and genetic analyses of medulloepithelioma in the posterior cranial fossa. Neuropathology. 2017;: pubmed publisher
    ..Partial resection of the tumor was performed and histological findings revealed multilayered rosettes with LIN28A staining, but genetic analysis showed no amplification of the C19MC microRNA cluster at 19q14.32...
  55. Ross S, Fraser S, Bagnall R, Semsarian C. Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. Stem Cell Res. 2017;20:76-79 pubmed publisher
    ..state following transfection with non-integrative episomal vectors carrying reprogramming factors OCT4, SOX2, LIN28, KLF4 and L-MYC...
  56. Mullany L, Herrick J, Wolff R, Slattery M. Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival. Genes Chromosomes Cancer. 2017;56:285-295 pubmed publisher
    ..SNP, rs2059691 (PRKRA), was associated with increased mRNA expression and worse survival, and one SNP, rs6598964 (LIN28A), decreased risk of developing colon cancer [OR = 0.77 95% CI (0.61, 0...
  57. Tan S, Altschuler G, Zhao T, Ang H, Yang H, Lim B, et al. Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation. Nucleic Acids Res. 2014;42:7997-8007 pubmed publisher
    b>LIN28 function is fundamental to the activity and behavior of human embryonic stem cells (hESCs) and induced pluripotent stem cells...
  58. Qin R, Zhou J, Chen C, Xu T, Yan Y, Ma Y, et al. LIN28 is involved in glioma carcinogenesis and predicts outcomes of glioblastoma multiforme patients. PLoS ONE. 2014;9:e86446 pubmed publisher
    b>LIN28, an evolutionarily conversed RNA binding protein which can bind to the terminal loops of let-7 family microRNA precursors and block their processing to maturation, is highly expressed in several subsets of tumors that carry poor ..
  59. Zhang J, Zhang L, Fan R, Guo N, Xiong C, Wang L, et al. The polymorphism in the let-7 targeted region of the Lin28 gene is associated with increased risk of type 2 diabetes mellitus. Mol Cell Endocrinol. 2013;375:53-7 pubmed publisher
    ..We performed a case-control study to investigate two polymorphisms in the let-7/Lin28 pathway based on 588 T2DM patients and 588 age and sex matched controls...
  60. Tang J, Li J, Cheng J, Hu B, Sun T, Li X, et al. Requirement for CCNB1 in mouse spermatogenesis. Cell Death Dis. 2017;8:e3142 pubmed publisher
    ..Moreover, CCNB1 ablation in spermatogonia may promote their differentiation by downregulating Lin28a and upregulating let-7 miRNA...
  61. Fu Z, Chen C, Zhou Q, Wang Y, Zhao Y, Zhao X, et al. LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9. Cancer Lett. 2017;410:68-81 pubmed publisher
    ..assays showed that HOTTIP alterations affected stemness, including sphericity, tumorigenesis, and stem factors (LIN28, NANOG, OCT4, and SOX2) and markers (ALDH1, CD44, and CD133)...
  62. Fernandes S, Talwadekar M, Agarwal R, Nair V, Kale V, Limaye L. Generation and characterization of human iPSC line from CD34+ cells isolated from umbilical cord blood belonging to Indian origin. Stem Cell Res. 2017;18:60-63 pubmed publisher
    ..The cells were nucleofected by episomal vectors expressing Oct4, Sox2, L-Myc, Klf4, Lin28 and p53DD (negative mutation in p53)...
  63. Zhang Y, Zhu J, Dai Y, Wang L, Liu R. Development of one control and one tumor-specific induced pluripotent stem cell line from laryngeal carcinoma patient. Stem Cell Res. 2017;25:283-285 pubmed publisher
    ..This in vitro cellular model can be used to study the oncogenesis and pathogenesis of laryngeal carcinoma. ..
  64. Yang J, Bennett B, Luo S, Inoue K, Grimm S, Schroth G, et al. LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells. Mol Cell Biol. 2015;35:3225-43 pubmed publisher
    b>LIN28 is an evolutionarily conserved RNA-binding protein with critical functions in developmental timing and cancer. However, the molecular mechanisms underlying LIN28's oncogenic properties are yet to be described...
  65. Lozier A, Rich M, Grawe A, Peck A, Zhao P, Chang A, et al. Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma. Oncotarget. 2015;6:196-206 pubmed
    b>LIN28 has emerged as an oncogenic driver in a number of cancers, including neuroblastoma (NB)...
  66. Wan Y, Sun G, Wang Z, Guo J, Shi L. miR-125b promotes cell proliferation by directly targeting Lin28 in glioblastoma stem cells with low expression levels of miR-125b. Neuroreport. 2014;25:289-96 pubmed publisher
    ..Further research into the underlying mechanism demonstrated that miR-125b acts by targeting Lin28 to regulate cell growth. Lin28 is highly expressed in human embryonic stem cells and glioblastomas...
  67. Gunsalus K, Wagoner M, Meyer K, Potter W, Schoenike B, Kim S, et al. Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors. Cancer Res. 2012;72:3207-16 pubmed publisher
    ..In this study, we show that loss of REST results in upregulation of LIN28A, a known promoter of tumor development, in breast cancer cell lines and human breast tumors...
  68. Chen A, Yu K, Fan L, Li J, Yang C, Huang A, et al. Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility. PLoS Genet. 2011;7:e1002259 pubmed publisher
    Previous studies have shown that let-7 can repress the post-transcriptional translation of LIN28, and LIN28 in turn could block the maturation of let-7, forming a double-negative feedback loop...
  69. Wang T, He Y, Zhu Y, Chen M, Weng M, Yang C, et al. Comparison of the expression and function of Lin28A and Lin28B in colon cancer. Oncotarget. 2016;7:79605-79616 pubmed publisher
    b>Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions. Recent studies demonstrated that both of them act as oncogenes and promote cancer progression...
  70. Sharma C, Mohanty D. Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28. Biochemistry. 2017;56:723-735 pubmed publisher
    b>LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells...
  71. Fang T, Lv H, Wu F, Wang C, Li T, Lv G, et al. Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation. Cancer Lett. 2017;384:50-59 pubmed publisher
    ..Mechanistically, overexpression of MSI2 resulted in the upregulation of Lin28A. Stemness and chemotherapeutic drug resistance induced by MSI2 overexpression were dramatically reduced by Lin28A ..
  72. Chen C, Chiu C, Lee K, Hsu C, Chen H, Huang T, et al. JAK2V617F influences epigenomic changes in myeloproliferative neoplasms. Biochem Biophys Res Commun. 2017;494:470-476 pubmed publisher
    ..HOXC9, and SRF) were clustered independently from the control locus (L1TD1) and other mutation genes (HMGA2 and Lin28A) in the analyzed MPN samples. Therefore, JAK2V617F influences target binding in both pSTAT3 and EZH2...
  73. Tummala R, Nadiminty N, Lou W, Zhu Y, Gandour Edwards R, Chen H, et al. Lin28 promotes growth of prostate cancer cells and activates the androgen receptor. Am J Pathol. 2013;183:288-95 pubmed publisher
    ..Having previously demonstrated the importance of the Lin28/let-7/Myc axis in CaP, we tested the hypothesis that Lin28 is overexpressed in CaP and that it activates AR and ..
  74. Yao K, Qiu S, Tian L, Snider W, Flannery J, Schaffer D, et al. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Rep. 2016;17:165-178 pubmed publisher
    ..Downstream of Wnt, β-catenin binds to the Lin28 promoter and activates transcription...
  75. Wang L, Nam Y, Lee A, Yu C, Roth K, Chen C, et al. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Rep. 2017;18:2664-2675 pubmed publisher
    b>LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis...
  76. Jakobiec F, Kool M, Stagner A, Pfister S, Eagle R, Proia A, et al. Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC. Am J Ophthalmol. 2015;159:1065-1074.e1 pubmed publisher
    ..with (2) immunohistochemical staining of paraffin sections using a polyclonal antibody against the protein LIN28A, and (3) fluorescence in situ hybridization (FISH) testing for the amplification of the genetic locus 19q13...
  77. Murray M, Saini H, Siegler C, Hanning J, Barker E, van Dongen S, et al. LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res. 2013;73:4872-84 pubmed publisher
    ..Microarray results from pediatric and adult samples (n = 45) showed that LIN28, the negative regulator of let-7 biogenesis, was abundant in malignant GCTs, regardless of patient age, tumor site,..