Gene Symbol: LILRB1
Description: leukocyte immunoglobulin like receptor B1
Alias: CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin-like receptor subfamily B member 1, CD85 antigen-like family member J, Ig-like transcript 2, leucocyte Ig-like receptor B1, leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1, monocyte/macrophage immunoglobulin-like receptor 7, myeloid inhibitory receptor 7
Species: human
Products:     LILRB1

Top Publications

  1. Young N, Waller E, Patel R, Roghanian A, Austyn J, Trowsdale J. The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells. Blood. 2008;111:3090-6 pubmed
    ..We demonstrate that the inhibitory receptor LILRB1 (ILT2, LIR1, CD85j) is selectively up-regulated during DC differentiation from monocyte precursors in culture...
  2. Tenca C, Merlo A, Merck E, Bates E, Saverino D, Simone R, et al. CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells. J Immunol. 2005;174:6757-63 pubmed
    ..DCs) derived from freshly isolated human monocytes were used to evaluate the effect of the inhibiting receptor CD85j (leukocyte Ig-like receptor-1/ILT2) on activation induced by cross-linking of the human osteoclast-associated ..
  3. Navarro F, Llano M, Bellon T, Colonna M, Geraghty D, Lopez Botet M. The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol. 1999;29:277-83 pubmed
    ..In the present study we re-evaluated the relative role played by CD94/NKG2 and ILT2(LIR1) molecules in recognition of HLA-G1 by NK clones. We employed as targets ...
  4. Samaridis J, Colonna M. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur J Immunol. 1997;27:660-5 pubmed
    ..The two cDNA, called immunoglobulin-like transcripts 1 and 2 (ILT1 and ILT2), are expressed in myeloid and lymphoid cells and are homologous to bovine Fc gamma2R, human killer cell inhibitory ..
  5. Bellón T, Kitzig F, Sayos J, Lopez Botet M. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol. 2002;168:3351-9 pubmed
    The inhibitory receptor Ig-like transcript (ILT)2 (leukocyte Ig-like receptor or CD85j) is a type I transmembrane protein expressed by different leukocyte lineages...
  6. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, et al. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997;7:273-82 pubmed
    ..Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function. ..
  7. Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. 1997;186:1809-18 pubmed
    ..In addition, myelomonocytic cells express receptors homologous to ILT2, which are characterized by extensive polymorphism and might recognize distinct HLA class I molecules...
  8. Saverino D, Merlo A, Bruno S, Pistoia V, Grossi C, Ciccone E. Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells. J Immunol. 2002;168:207-15 pubmed
    ..Cross-linking of CD85/LIR-1/ILT2 or CD152 molecules on cultured T cells using specific mAb and goat anti-mouse antiserum inhibits Ag-specific T cell ..
  9. Huang J, Burke P, Cung T, Pereyra F, Toth I, Walker B, et al. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol. 2010;84:9463-71 pubmed publisher
    ..of immunomodulatory leukocyte-immunoglobulin-like receptors (LILR) and a strong and selective upregulation of LILRB1 and LILRB3...

More Information


  1. Fanger N, Cosman D, Peterson L, Braddy S, Maliszewski C, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998;28:3423-34 pubmed
    ..These findings suggest that LIR-1 and LIR-2 function as unique MHC class I receptors involved in the inhibition or down-modulation of monocyte activation signals, particularly those mediated through the receptors for IgG, IgE and IgA. ..
  2. Monsiváis Urenda A, Niño Moreno P, Abud Mendoza C, Baranda L, Layseca Espinosa E, Lopez Botet M, et al. Analysis of expression and function of the inhibitory receptor ILT2 (CD85j/LILRB1/LIR-1) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE). J Autoimmun. 2007;29:97-105 pubmed
    The aim of this work was to study the expression and function of the inhibitory receptor ILT2/CD85j in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)...
  3. Saverino D, Ghiotto F, Merlo A, Bruno S, Battini L, Occhino M, et al. Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells. J Immunol. 2004;172:5629-37 pubmed
    ..We show that interaction between the viral protein UL18 on infected cells and the invariant receptor CD85j/LIR-1/ILT2 expressed on CTL is relevant for the control of infection...
  4. Willcox B, Thomas L, Bjorkman P. Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. Nat Immunol. 2003;4:913-9 pubmed
    ..The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members. ..
  5. Morel E, Bellón T. HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J Immunol. 2008;181:2368-81 pubmed
    ..Specifically, no data are available referring to the role of the iNKR ILT2/CD85j in the regulation of IFN-gamma secretion by NK cells...
  6. Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long E. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. Curr Biol. 1997;7:615-8 pubmed
  7. Lepin E, Bastin J, Allan D, Roncador G, Braud V, Mason D, et al. Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. Eur J Immunol. 2000;30:3552-61 pubmed
    ..HLA-F tetramer binding could be conferred on non-binding cells by transfection with the inhibitory receptors ILT2 and ILT4. Surface plasmon resonance studies demonstrated a direct molecular interaction of HLA-F with ILT2 and ILT4...
  8. Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud V, et al. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A. 2003;100:8856-61 pubmed
    ..expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) is expressed on a wider range of immune cells including subsets of natural killer and T cells...
  9. Anfossi N, Doisne J, Peyrat M, Ugolini S, Bonnaud O, Bossy D, et al. Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells. J Immunol. 2004;173:7223-9 pubmed
    ..T cells that express the Ig-like MHC class I-specific inhibitory receptors: killer cell Ig-like receptor (KIR) and CD85j. The cell surface expression of Ig-like inhibitory MHC class I receptors was found to correlate with an advanced ..
  10. Willcox B, Thomas L, Chapman T, Heikema A, West A, Bjorkman P. Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. BMC Struct Biol. 2002;2:6 pubmed
    Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (microM) affinities...
  11. Chapman T, Heikeman A, Bjorkman P. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity. 1999;11:603-13 pubmed
    ..LIR-1 recognition of class I molecules resembles the CD4-class II MHC interaction more than the KIR-class I interaction, implying a functional distinction between LIR-1 and KIRs. ..
  12. McIntire R, Sifers T, Platt J, Ganacias K, Langat D, Hunt J. Novel HLA-G-binding leukocyte immunoglobulin-like receptor (LILR) expression patterns in human placentas and umbilical cords. Placenta. 2008;29:631-8 pubmed publisher
    ..b>LILRB1 is expressed by most leukocytes and LILRB2 is expressed primarily by monocytes, macrophages and dendritic cells...
  13. Young N, Canavez F, Uhrberg M, Shum B, Parham P. Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. Immunogenetics. 2001;53:270-8 pubmed
    ..Investigation of gene expression identified novel cDNA sequences related to the ILT2/LIR1, ILT4/LIR2, ILT3/LIR5, and ILT7 loci, while phylogenetic analysis revealed two distinct lineages of ILT/LIR ..
  14. Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, et al. Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Proc Natl Acad Sci U S A. 2006;103:16412-7 pubmed
    ..Notably, LILRB1 cannot recognize the beta(2)m-free form of HLA-G or HLA-B27, but LILRB2 can recognize the beta(2)m-free form of ..
  15. Borges L, Hsu M, Fanger N, Kubin M, Cosman D. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J Immunol. 1997;159:5192-6 pubmed
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation. ..
  16. Favier B, Lemaoult J, Lesport E, Carosella E. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. FASEB J. 2010;24:689-99 pubmed publisher the surface of tumoral cells confers a protection against NK-cell cytolysis through its interaction with the ILT2 inhibitory receptor...
  17. Jones D, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, et al. HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding. J Immunol. 2011;186:2990-7 pubmed publisher
    ..We comprehensively assessed LILR binding to >90 HLA class I alleles. The inhibitory receptors LILRB1 and LILRB2 varied in their level of binding to different HLA alleles, correlating in some cases with specific ..
  18. Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, et al. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet. 2005;14:2469-80 pubmed
    Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1/LIR1/ILT2) is an inhibitory receptor broadly expressed on leukocytes and recognizes HLA-class I and human cytomegalovirus UL18...
  19. Davidson C, Li N, Burshtyn D. LILRB1 polymorphism and surface phenotypes of natural killer cells. Hum Immunol. 2010;71:942-9 pubmed publisher
    ..receptor (LIR)-1 is an inhibitory receptor that binds a broad range of class I HLA molecules and is encoded by the LILRB1 gene within the leukocyte receptor complex...
  20. Godal R, Bachanova V, Gleason M, McCullar V, Yun G, Cooley S, et al. Natural killer cell killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts by killer cell immunoglobulin-like receptor-negative natural killer cells after NKG2A and LIR-1 blockade. Biol Blood Marrow Transplant. 2010;16:612-21 pubmed publisher
    ..Thus strategies to interrupt NKG2A and LIR-1 in combination with anti-KIR blockade hold promise for exploiting NK cell therapy in acute leukemias. ..
  21. Shiroishi M, Kuroki K, Ose T, Rasubala L, Shiratori I, Arase H, et al. Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. J Biol Chem. 2006;281:10439-47 pubmed
    ..Here we performed binding studies showing that the HLA-G dimer exhibited higher overall affinity to LILRB1/2 than the monomer by significant avidity effects...
  22. Scott Algara D, Arnold V, Didier C, Kattan T, Pirozzi G, Barré Sinoussi F, et al. The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells. PLoS ONE. 2008;3:e1975 pubmed publisher
    ..In particular, expression of the CD85j receptor on NK cells was strongly down-regulated upon coculture with HIV-1-infected MDDC...
  23. Chapman T, Heikema A, West A, Bjorkman P. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity. 2000;13:727-36 pubmed
    ..The LIR-1 binding site comprises a portion of D1 distant from the interdomain hinge region that constitutes the KIR binding site, consistent with differences in LIR-1 and KIR recognition properties and functions. ..
  24. Li C, Houser B, Nicotra M, Strominger J. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci U S A. 2009;106:5767-72 pubmed publisher
    ..leukocyte antigen (HLA)-G (an MHC class Ib protein that is expressed on extravillous trophoblasts), LILRB1 on CD14(+) macrophages and KIR2DL4 on CD56(+) NK cells...
  25. Ahmed F, Ahmed N, Gouda M, Vos P, Bonnerup C. RT-qPCR for Fecal Mature MicroRNA Quantification and Validation. Methods Mol Biol. 2018;1765:203-215 pubmed publisher
  26. Hu Y, Zhang X, Cui M, Su Z, Wang M, Liao Q, et al. Verification of candidate microRNA markers for parathyroid carcinoma. Endocrine. 2018;60:246-254 pubmed publisher
    ..miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd. The combined analysis of miR-139 and miR-30b may be used as a potential diagnostic strategy for distinguishing PCa from PAd. ..
  27. Martinez Rodriguez J, Sáez Borderías A, Munteis E, Romo N, Roquer J, Lopez Botet M. Natural killer receptors distribution in multiple sclerosis: Relation to clinical course and interferon-beta therapy. Clin Immunol. 2010;137:41-50 pubmed publisher
    ..Here, we show that the proportions of CD8+ T cells displaying LILRB1, an inhibitory NKR expressed at late stages of T cell differentiation, were directly related with age and MS ..
  28. Chen Y, Gao F, Chu F, Peng H, Zong L, Liu Y, et al. Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J Mol Biol. 2009;386:841-53 pubmed
    ..b>LILRB1 (ILT2), LILRB2 (ILT4) and LILRA1 (LIR6) can recognize MHC (major histocompatibility complex) class I or class I-..
  29. Luo H, Liang H, Chen Y, Chen S, Xu Y, Xu L, et al. miR-7-5p overexpression suppresses cell proliferation and promotes apoptosis through inhibiting the ability of DNA damage repair of PARP-1 and BRCA1 in TK6 cells exposed to hydroquinone. Chem Biol Interact. 2018;283:84-90 pubmed publisher
    ..The increase of miR-7-5p expression further intensified downregulation of PARP-1 and BRCA1 in TK6-miR-7-5p cells, resulting in an increase of apoptosis and proliferation inhibited. ..
  30. Li D, Wang L, Yu L, Freundt E, Jin B, Screaton G, et al. Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction. J Immunol. 2009;182:1033-40 pubmed
    ..The interaction between ILT4 and CD1d may provide new insights into the regulation of NKT-mediated immunity. ..
  31. Smith K, Starmer J, Miller S, Sethupathy P, Magnuson T. Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells. Stem Cell Reports. 2017;9:108-121 pubmed publisher
    ..This suggests that Cyrano functions to restrain the action of mir-7. Altogether, we provide a view into the multifaceted function of Cyrano in ESC maintenance. ..
  32. Cui Y, Bradbury R, Flamini V, Wu B, Jordan N, Jiang W. MicroRNA-7 suppresses the homing and migration potential of human endothelial cells to highly metastatic human breast cancer cells. Br J Cancer. 2017;117:89-101 pubmed publisher
  33. Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
  34. Kabaria S, Choi D, Chaudhuri A, Jain M, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56 pubmed publisher
    ..These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway. ..
  35. Tedla N, Lee C, Borges L, Geczy C, Arm J. Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells. J Leukoc Biol. 2008;83:334-43 pubmed
    ..Progenitor mast cells expressed cell surface inhibitory LILRB1, -B2, -B3, and -B4 and activating LILRA1...
  36. de Almeida B, Garcia N, Maffazioli G, Gonzalez Dos Anjos L, Chada Baracat E, Candido Carvalho K. Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. Int J Mol Sci. 2017;19: pubmed publisher
    ..This led to alterations in their mRNA-target. ..
  37. Melsted W, Matzen S, Andersen M, Hviid T. The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G. Cell Immunol. 2018;324:14-23 pubmed publisher
    ..the expression of HLA-G+CD4+ and CD8+ T cells, and decreases the expression of ILT2+ on CD4+ T cells in resting PBMCs after six days of co-culture...
  38. Rothe K, Raulien N, Kohler G, Pierer M, Quandt D, Wagner U. Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4+ T cells from SKG mice. Eur J Immunol. 2017;47:1457-1467 pubmed publisher
    ..More importantly, a major population of PIR-B+ T cells in SKG mice appears to play an inhibitory role by way of their IFN-? production, since high frequencies of those cells ameliorate the disease. ..
  39. Dulberger C, McMurtrey C, Hölzemer A, Neu K, Liu V, Steinbach A, et al. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors. Immunity. 2017;46:1018-1029.e7 pubmed publisher
    ..The complex structure of peptide-loaded ?2m-HLA-F bound to the inhibitory LIR1 revealed similarities to high-affinity recognition of the viral MHC-I mimic UL18 and a docking strategy that relies ..
  40. Shen Z, Qin X, Yan M, Li R, Chen G, Zhang J, et al. Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment. Oncotarget. 2017;8:1290-1303 pubmed publisher
    ..Thus, these results reveal that the inactivation of the RASSF2-PAR-4 axis controlled by miR-7 may be a novel strategy for gene therapy in HNCs. ..
  41. Chen K, Stanton R, Banat J, Wills M. Leukocyte Immunoglobulin-Like Receptor 1-Expressing Human Natural Killer Cell Subsets Differentially Recognize Isolates of Human Cytomegalovirus through the Viral Major Histocompatibility Complex Class I Homolog UL18. J Virol. 2016;90:3123-37 pubmed publisher
    ..NK cells were used, cells expressing or lacking the inhibitory receptor leukocyte immunoglobulin-like receptor 1 (LIR1) were differentially able to control dissemination...
  42. Liu X, Li G, Su Z, Jiang Z, Chen L, Wang J, et al. Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells. Oncol Rep. 2013;29:1387-94 pubmed publisher
    ..These investigations provide a basis for developing high-efficiency micromolecular drug delivery. ..
  43. Moysey R, Li Y, Paston S, Baston E, Sami M, Cameron B, et al. High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation. Protein Cell. 2010;1:1118-27 pubmed publisher
    ..phage display on a soluble fragment of the human immunoglobulin super-family receptor ILT2 (synonyms: LIR1, MIR7, CD85j), we have selected a range of mutants with binding affinities enhanced by up to 168,000-fold towards the conserved ..
  44. Zhang F, Zheng J, Kang X, Deng M, Lu Z, Kim J, et al. Inhibitory leukocyte immunoglobulin-like receptors in cancer development. Sci China Life Sci. 2015;58:1216-25 pubmed publisher
    Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 ..
  45. Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, et al. Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2. J Virol. 2010;84:10784-91 pubmed publisher
    ..receptor B2 (LILRB2; ILT4), while binding of soluble HLA-G to its alternative high-affinity receptor, LILRB1 (ILT2), appeared to be less relevant for its immunomodulatory functions on dendritic cells...
  46. Li C, Gong D, Chen L, Zhang M, Xia X, Cheng H, et al. Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. Eur J Pharmacol. 2017;811:74-86 pubmed publisher
    ..Our study demonstrates that puerarin promotes ABCA1-mediated cholesterol efflux and decreases intracellular cholesterol levels through the pathway involving miR-7, STK11, and the AMPK-PPAR?-LXR-?-ABCA1 cascade. ..
  47. Gu D, Jiang M, Mei Z, Dai J, Dai C, Fang C, et al. microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. Cancer Lett. 2017;400:69-78 pubmed publisher
    ..Hence, miR-7 might be a potential therapeutic target in pancreatic cancer. ..
  48. Rouas Freiss N, Lemaoult J, Verine J, Tronik Le Roux D, Culine S, Hennequin C, et al. Intratumor heterogeneity of immune checkpoints in primary renal cell cancer: Focus on HLA-G/ILT2/ILT4. Oncoimmunology. 2017;6:e1342023 pubmed publisher
    ..We focused on well-known checkpoints such as PD1/PDL1 and on a new checkpoint involving HLA-G and its receptors ILT2/ILT4...
  49. Je G, Kim Y. Mitochondrial ROS-mediated post-transcriptional regulation of ?-synuclein through miR-7 and miR-153. Neurosci Lett. 2017;661:132-136 pubmed publisher
    ..Together, our results suggest that MPP+-mediated increased ?-SYN levels are contributed by mitochondrial ROS-mediated de novo protein synthesis which is regulated by miRNA-7 and miR-153. ..
  50. Hromadnikova I, Pirkova P, Sedlackova L. Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp-70-derived 14-mer peptide (TKD) on the expression of NK cell activatory and inhibitory receptors. Mediators Inflamm. 2013;2013:405295 pubmed publisher
    ..NKG2D, NKG2C, NKp46, NKp44, NKp30, KIR2DL4, DNAM-1, and LAMP1) and NK inhibitory receptors (NKG2A, KIR2DL2/L3, LIR1/ILT-2, and NKR-P1A) in healthy individuals was studied...
  51. Pan H, Li T, Jiang Y, Pan C, Ding Y, Huang Z, et al. Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway. J Cell Biochem. 2018;119:440-446 pubmed publisher
    ..ciRS-7 may act as a prospective prognostic biological marker and a promising therapeutic target for GC. J. Cell. Biochem. 119: 440-446, 2018. © 2017 Wiley Periodicals, Inc. ..
  52. Makwana N, Foley B, Lee S, Fernandez S, Irish A, Price P. Asymptomatic CMV infections in long-term renal transplant recipients are associated with the loss of FcR? from LIR-1+ NK cells. Eur J Immunol. 2016;46:2597-2608 pubmed publisher
    ..Continuous exposure to CMV may maintain and expand NK cells that lack FcR? but express LIR-1. ..
  53. Li N, Fu L, Uchtenhagen H, Achour A, Burshtyn D. Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. Eur J Immunol. 2013;43:1042-52 pubmed publisher
    Leukocyte Ig-like receptor (LIR) 1 (CD85j/ILT2/LILRB1) is an inhibitory receptor with broad specificity for MHC class I (MHC-I) and the human CMV MHC-I homologue UL18...
  54. Sayos J, Martinez Barriocanal A, Kitzig F, Bellón T, Lopez Botet M. Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j. Biochem Biophys Res Commun. 2004;324:640-7 pubmed
    The CD85j inhibitory receptor (also termed ILT2 or LIR-1) is a type-I transmembrane protein that belongs to the Ig superfamily and is expressed by different leukocyte lineages...
  55. Zhong M, Weng X, Liang Z, Lu S, Li J, Chen X, et al. Dimerization of soluble HLA-G by IgG-Fc fragment augments ILT2-mediated inhibition of T-cell alloresponse. Transplantation. 2009;87:8-15 pubmed publisher
    ..Our results also indicate that sHLA-G dimer up-regulates inhibitory receptor ILT2 on alloreactive CD8+ T cells, which contributes to the significant inhibition on T-cell alloresponse...
  56. Cao Q, Mao Z, Shi Y, Chen Y, Sun Y, Zhang Q, et al. MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway. Oncotarget. 2016;7:77468-77481 pubmed publisher
    ..The miR-7 and its target gene FAK may be novel targets for the diagnosis and treatment of NSCLC. ..
  57. Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, et al. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding. Protein Cell. 2013;4:761-70 pubmed publisher
    ..Here, we report the crystal structures of the D3D4 domains of both LILRB1 and LILRB2...
  58. Lichterfeld M, Yu X. The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection. J Leukoc Biol. 2012;91:27-33 pubmed publisher
    ..Obtaining a more complete understanding of LILR-mediated immune regulation during HIV-1 infection may ultimately allow for improved strategies to treat or prevent HIV-1-associated disease manifestations. ..
  59. Ma X, Hua J, Zheng G, Li F, Rao C, Li H, et al. Regulation of cell proliferation in the retinal pigment epithelium: differential regulation of the death associated protein like-1 DAPL1 by alternative MITF splice forms. Pigment Cell Melanoma Res. 2017;: pubmed publisher
    ..This article is protected by copyright. All rights reserved...
  60. Brown R, Richardson K, Kalinowski F, Epis M, Horsham J, Kabir T, et al. Evaluation of MicroRNA Delivery In Vivo. Methods Mol Biol. 2018;1699:155-178 pubmed publisher
    ..Together, these methods will provide a foundation for those planning on assessing the efficacy of delivery of a miRNA in vivo. ..
  61. Wu D, Wang Y, Fan L, Luo H, Han B, Sun L, et al. MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. Chin Med J (Engl). 2011;124:2616-21 pubmed
    ..To our knowledge, these data indicate for the first time that miR-7 directly regulates cell invasion by targeting FAK in glioblastoma and that miR-7 could be a potential therapeutic target for glioblastoma intervention. ..
  62. Kabir T, Ganda C, Brown R, Beveridge D, Richardson K, Chaturvedi V, et al. A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma. Hepatology. 2017;: pubmed publisher
    ..Furthermore, miR-7 effectively silenced TYRO3 expression in both sorafenib-sensitive and sorafenib-resistant Huh-7 cells, inhibiting TYRO3/growth arrest specific 6-mediated cancer cell migration and invasion...
  63. Yang X, Xiong Q, Wu Y, Li S, Ge F. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells. J Proteome Res. 2017;16:3891-3902 pubmed publisher
    ..This study serves as the first proteome-wide analysis of a circRNA-regulated protein in cells and provides a reliable and highly efficient method for globally identifying circRNA-regulated proteins. ..
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