LIFR

Summary

Gene Symbol: LIFR
Description: LIF receptor alpha
Alias: CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor, CD118 antigen, LIF receptor, leukemia inhibitory factor receptor alpha
Species: human
Products:     LIFR

Top Publications

  1. Gearing D, Bruce A. Oncostatin M binds the high-affinity leukemia inhibitory factor receptor. New Biol. 1992;4:61-5 pubmed
    ..leukemic cells, endothelial cells, macrophages, and cells transfected with the recently cloned low-affinity LIF receptor, and to a soluble form of the LIF receptor...
  2. Gearing D, Comeau M, Friend D, Gimpel S, Thut C, McGourty J, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992;255:1434-7 pubmed
    ..structurally and functionally related to another cytokine, Oncostatin M (OSM), that binds to the high-affinity LIF receptor but not to the low-affinity LIF receptor...
  3. Gearing D, Thut C, VandeBos T, Gimpel S, Delaney P, King J, et al. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991;10:2839-48 pubmed
    ..A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library...
  4. Tomida M, Gotoh O. Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor. J Biochem. 1996;120:201-5 pubmed
    ..The gene spans more than 70 kilobases and contains 20 exons. The D-factor/LIF receptor can be subdivided into several regions; cytokine receptor homologous domain 1, an Ig-like domain, cytokine ..
  5. Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park L, et al. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem. 1996;271:32635-43 pubmed
    ..A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor (LIFR) and gp130. This LIFR.gp130 complex is also a functional receptor for LIF...
  6. Blanchard F, Duplomb L, Wang Y, Robledo O, Kinzie E, Pitard V, et al. Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase. J Biol Chem. 2000;275:28793-801 pubmed
    Leukemia inhibitory factor (LIF) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit (LIFRalpha) and the common signal transducing subunit for interleukin-6 cytokine receptors, gp130...
  7. Dagoneau N, Scheffer D, Huber C, Al Gazali L, Di Rocco M, Godard A, et al. Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome. Am J Hum Genet. 2004;74:298-305 pubmed
    ..1 at locus D5S418 (Zmax=10.66 at theta =0) and have identified null mutations in the leukemia inhibitory factor receptor (LIFR or gp190 chain) gene. A total of 14 distinct mutations were identified in the 19 families...
  8. Dagoneau N, Bellais S, Blanchet P, Sarda P, al Gazali L, Di Rocco M, et al. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. Am J Hum Genet. 2007;80:966-70 pubmed
    ..We report here the exclusion of the leukemia inhibitory factor receptor gene in Crisponi syndrome and the identification of homozygote or compound heterozygote cytokine ..
  9. Zou X, Huang W, Lu F, Fang K, Wang D, Zhao S, et al. The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation. BMC Complement Altern Med. 2017;17:165 pubmed publisher
    ..result showed that the administration of JTW significantly increased total sleep time and total slow wave sleep (SWS) time in OR rats with PSD...

More Information

Publications131 found, 100 shown here

  1. Pan W, Yu C, Hsuchou H, Kastin A. The role of cerebral vascular NFkappaB in LPS-induced inflammation: differential regulation of efflux transporter and transporting cytokine receptors. Cell Physiol Biochem. 2010;25:623-30 pubmed publisher
    ..enriched cerebral microvessels, and determined target mRNA by qPCR for MDR1a/b, IL15Ralpha, IL2 Ralpha, IL2Rgamma, LIFR, gp130, and TNFR1/2, and protein expression by western blotting for P-gp, IL15Ralpha, IL2Rgamma, LIFR, and gp130...
  2. Ma Y, Chen H, Tzeng C. Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro. J Ovarian Res. 2017;10:47 pubmed publisher
    ..peroxiredoxin 5, PRDX5) were assessed using quantitative RT-PCR and implantation-related protein (Leukemia Inhibitory Factor Receptor, LIFR) was validated by immunofluorescence...
  3. Hu Q, Huang C, Wang Y, Wu R. Expression of leukemia inhibitory factor in the rat retina following acute ocular hypertension. Mol Med Rep. 2015;12:6577-83 pubmed publisher
    ..The expression levels of LIF, LIF receptor (LIFR), signal transducers and activators of transcription 3 (STAT3), phosphorylated STAT3 (P‑STAT3), ..
  4. Zhao P, Wang Y, Liu X, Zhu Y, Zhao H, Zhang Q, et al. Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis. J Ethnopharmacol. 2018;217:36-48 pubmed publisher
    ..The protein expressions of semaphorins (Sema) 3A, Neuropilin (NRP) -?1, leukemia inhibitory factor (LIF), LIF receptor (LIFR) and Nkx6.2 were further investigated by western blot...
  5. Frey H, Stout M, Pearson L, Tuuli M, Cahill A, Strauss J, et al. Genetic variation associated with preterm birth in African-American women. Am J Obstet Gynecol. 2016;215:235.e1-8 pubmed publisher
    ..Genetic variants related to MMP2, matrix metalloproteinase-1 (MMP1), and leukemia inhibitory factor receptor antisense RNA 1 (LIFR-AS1) genes were associated with higher rates of preterm birth <34 weeks...
  6. Tan A, Chong W. A child with Apert syndrome and Sturge-Weber syndrome: could fibronectin or the RAS/MAPK signaling pathway be the connection?. Childs Nerv Syst. 2018;34:1247-1250 pubmed publisher
    ..Sturge-Weber syndrome (SWS) on the other hand is a congenital neurocutaneous disorder characterized by facial port-wine stains (PWSs) and ..
  7. Zhang J, Chen L, Zheng C, Wang J, Xie D, Zhou Y. Effect of Shoutai Pills on Th1/Th2 Cytokines in Serum and Endometrium of Rats with Stimulated Ovulation. Curr Med Sci. 2019;39:285-290 pubmed publisher
    ..The expression of leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) was detected by Western blotting and real-time PCR...
  8. Sokolov D, Furaeva K, Stepanova O, Ovchinnikova O, Viazmina L, Kozonov G, et al. Changes in Functional Activity of JEG-3 Trophoblast Cell Line in the Presence of Factors Secreted by Placenta. Arch Med Res. 2015;46:245-56 pubmed publisher
    ..Expression of CD116, CD118, CD119, IFNγ-R2, CD120b, CD183, CD192, CD295, EGFR, and TGFβ-R2 on JEG-3 was higher when the cells were ..
  9. Larsen J, Kristensen A, Pallesen L, Bauer J, Vægter C, Nielsen M, et al. Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover. Mol Cell Biol. 2016;36:1272-86 pubmed publisher
    ..neurotrophic factor receptor α (CNTFRα) and is a prerequisite for signaling through the gp130/leukemia inhibitory factor receptor β (LIFRβ) heterodimer, whereas CLF-1 serves to promote the cellular release of CLC...
  10. Murillo Rodriguez E, Palomero Rivero M, Millán Aldaco D, Arias Carrión O, Drucker Colín R. Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats. PLoS ONE. 2011;6:e20766 pubmed publisher
    ..Sleep stages were scored to determine W, slow wave sleep (SWS) and rapid eye movement sleep (REMS)...
  11. Uchino H, Kong V, Bruce J, Oosthuizen G, Bekker W, Laing G, et al. Preparing Japanese surgeons for potential mass casualty situations will require innovative and systematic programs. Eur J Trauma Emerg Surg. 2019;45:139-144 pubmed publisher
    ..The mechanisms of injury for penetrating trauma were as follows: stab wounds (SWs); 955 (77%), gunshot wounds (GSWs); 252 (20%), and other injuries; 37 (3%) and for blunt trauma were as follows: ..
  12. Jacobson L, Chen S, Mir S, Hoyer D. Orexin OX2 Receptor Antagonists as Sleep Aids. Curr Top Behav Neurosci. 2017;33:105-136 pubmed publisher
    ..DORAs promote sleep primarily by increasing rapid eye movement (REM) and are almost devoid of effects on slow-wave (SWS) sleep...
  13. Gelber R, Redline S, Ross G, Petrovitch H, Sonnen J, Zarow C, et al. Associations of brain lesions at autopsy with polysomnography features before death. Neurology. 2015;84:296-303 pubmed publisher
    ..of apnea or hypopnea, duration of hypoxemia, minimum oxygen saturation (SpOâ‚‚), duration of slow-wave sleep (SWS, non-REM stage N3), and arousals...
  14. Plante D. Nocturnal sleep architecture in idiopathic hypersomnia: a systematic review and meta-analysis. Sleep Med. 2018;45:17-24 pubmed publisher
    ..sleep onset latency (SOL), sleep efficiency (SE), rapid eye movement (REM) sleep percentage, slow wave sleep (SWS) percentage, and REM latency (REML)...
  15. Subramani E, Madogwe E, Ray C, Dutta S, Chakravarty B, Bordignon V, et al. Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis?. Fertil Steril. 2016;105:1076-1084.e5 pubmed publisher
    ..endometrial receptivity markers including αvβ3 integrin, E-cadherin, MECA-79, mucin-1, and pinopodes and LIF/LIFR-STAT3 signaling molecules expressed in the endometrium of women with dormant genital tuberculosis (GTB) during ..
  16. Jalvy S, Veschambre P, Fedou S, Rezvani H, Theze N, Thiebaud P. Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor. Dev Biol. 2019;447:200-213 pubmed publisher
    ..It signals through a heterodimer receptor complex that consists of the LIF receptor (or LIFR formerly known as gp190) and the Interleukin 6 signal transducer (or IL6ST formerly known as gp130)...
  17. Blanco W, Pereira C, Cota V, Souza A, Rennó Costa C, Santos S, et al. Synaptic Homeostasis and Restructuring across the Sleep-Wake Cycle. PLoS Comput Biol. 2015;11:e1004241 pubmed publisher
    ..the sleep-wake cycle, but animals exposed to novel objects showed a decrease during subsequent slow-wave sleep (SWS) followed by a rebound during rapid-eye-movement sleep (REM)...
  18. Zhang F, Li K, Pan M, Li W, Wu J, Li M, et al. miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop. J Exp Clin Cancer Res. 2018;37:152 pubmed publisher
    ..as wound healing, transwell assays and in vivo assays, were used to detect the biological effect of miR-589 and LIFR. We determined the role of miR-589 in gastric cancer tumorigenesis in vivo using xenograft nude models...
  19. Oyanedel C, Kelemen E, Scheller J, Born J, Rose John S. Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture. Brain Behav Immun. 2015;50:178-185 pubmed publisher
    ..less sleep, particularly during the late light phase, and this was accompanied by decreases in slow wave sleep (SWS) and rapid eye movement (REM) sleep...
  20. Schmidt E, Linz B, Diekelmann S, Besedovsky L, Lange T, Born J. Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes. Brain Behav Immun. 2015;47:178-85 pubmed publisher
    ..Various animal studies report a sleep-promoting effect of IL-1 leading to enhanced slow wave sleep (SWS). Moreover, this cytokine was shown to affect hippocampus-dependent memory...
  21. Kubicka TrzÄ…ska A, Karska Basta I, Oleksy P, Romanowska Dixon B. Management of diffuse choroidal hemangioma in Sturge-Weber syndrome with Ruthenium-106 plaque radiotherapy. Graefes Arch Clin Exp Ophthalmol. 2015;253:2015-9 pubmed publisher
    ..A retrospective analysis was performed in five patients treated for DCH associated with Sturge-Weber syndrome (SWS). In all cases, Ruthenium-106 plaque therapy with a target apex dose of 30.98-47.36 Gy (mean:38.9 Gy) was performed...
  22. Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and antidepressant treatment. Curr Pharm Des. 2012;18:5802-17 pubmed
    ..with abnormalities in the sleep pattern that include disturbances of sleep continuity, diminished slow-wave sleep (SWS) and altered rapid eye movement (REM) sleep parameters...
  23. Esquirol Y, Bongard V, Ferrieres J, Verdier H, Perret B. Shiftwork and higher pancreatic secretion: early detection of an intermediate state of insulin resistance?. Chronobiol Int. 2012;29:1258-66 pubmed publisher
    ..A cross-sectional study has recruited 97 shiftworkers (SWs) (three shifts, 8 h) and 95 strictly day workers (DWs) from the same plant for 2001-2002...
  24. Büttner M, Jezova D, Greene B, Konrad C, Kircher T, Murck H. Target-based biomarker selection - Mineralocorticoid receptor-related biomarkers and treatment outcome in major depression. J Psychiatr Res. 2015;66-67:24-37 pubmed publisher
    ..Easy to use e-devices were used to measure markers of central MR function, i.e. slow wave sleep (SWS) and heart-rate variability (HRV). Salt-taste intensity (STI) and salt pleasantness (SP) of a 0...
  25. Macdonald Wallis C, Silverwood R, de Stavola B, Inskip H, Cooper C, Godfrey K, et al. Antenatal blood pressure for prediction of pre-eclampsia, preterm birth, and small for gestational age babies: development and validation in two general population cohorts. BMJ. 2015;351:h5948 pubmed publisher
    ..ALSPAC) to develop prediction models and validated these in 3005 women from the Southampton Women's Survey (SWS)...
  26. Wells A, Ridener E, Bourbonais C, Kim W, Pantazopoulos H, Carroll F, et al. Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism. J Neurosci. 2017;37:7656-7668 pubmed publisher
    ..CSDS affected numerous endpoints, including paradoxical sleep (PS) and slow-wave sleep (SWS), as well as the circadian rhythmicity of body temperature and locomotor activity...
  27. Salm F, Dimitrova V, von Bueren A, Ćwiek P, Rehrauer H, Djonov V, et al. The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. PLoS ONE. 2015;10:e0123958 pubmed publisher
    ..Among these genes, the leukemia inhibitory factor receptor α (LIFR α) was validated as a novel p110α target in medulloblastoma...
  28. Ben David G, Miller E, Steinhauer J. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Spermatogenesis. 2015;5:e1006089 pubmed
    ..In contrast, modulating phospholipid levels by mutation of the phosphatidylcholine lipase Swiss cheese (Sws) or the ethanolamine kinase Easily shocked (Eas) does not perturb individualization, nor does Sws overexpression...
  29. Touzet C. Morvan's syndrome and the sustained absence of all sleep rhythms for months or years: An hypothesis. Med Hypotheses. 2016;94:51-4 pubmed publisher
    ..active together - which is exactly what happens with the travelling depolarization waves of the slow-wave sleep (SWS). The best documented cases of months-long insomnia are reports of patients with Morvan's syndrome...
  30. Ghosh A, Ghosh A, Datta S, Dasgupta D, Das S, Ray S, et al. Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma. Int J Cancer. 2016;138:2732-44 pubmed publisher
    ..two miRNAs in hepato-carcinogenesis, target genes related to cancer pathways (APAF1, APC2, CDKN2A, IRS1, CRKL, LIFR, EGR2) were verified...
  31. Parmentier R, Zhao Y, Perier M, Akaoka H, Lintunen M, Hou Y, et al. Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model. Neuropharmacology. 2016;106:20-34 pubmed publisher
    ..1) a decrease in W after lights-off despite its normal baseline daily amount; 2) a decreased EEG slow wave sleep (SWS)/W power ratio; 3) inability to maintain W in response to behavioral challenges demonstrated by a decreased sleep ..
  32. Maciejczyk M, Szulimowska J, Skutnik A, Taranta Janusz K, Wasilewska A, Wiśniewska N, et al. Salivary Biomarkers of Oxidative Stress in Children with Chronic Kidney Disease. J Clin Med. 2018;7: pubmed publisher
    ..the aim of the study was to evaluate oxidative stress indicators in the non-stimulated (NWS) and stimulated saliva (SWS) of CKD children (n = 25) and healthy controls (n = 25)...
  33. Voz M, Aström A, Kas K, Mark J, Stenman G, Van de Ven W. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Oncogene. 1998;16:1409-16 pubmed
    ..of a chimeric transcript consisting of sequences from the ubiquitously expressed gene for the leukemia inhibitory factor receptor (LIFR) and PLAG1...
  34. Dymerska M, Kirkorian A, Offermann E, Lin D, Comi A, Cohen B. Size of Facial Port-Wine Birthmark May Predict Neurologic Outcome in Sturge-Weber Syndrome. J Pediatr. 2017;188:205-209.e1 pubmed publisher
    To determine whether the size of the birthmark in patients with Sturge-Weber syndrome (SWS) who have brain involvement can help predict neurologic disability...
  35. Touzet C. Sleep: The hebbian reinforcement of the local inhibitory synapses. Med Hypotheses. 2015;85:359-64 pubmed publisher
    ..The period of time during which such slow waves are experienced has been named the "slow-wave sleep" (SWS)...
  36. Bourdiec A, Ahmad S, Lachhab A, Akoum A. Regulation of inflammatory and angiogenesis mediators in a functional model of decidualized endometrial stromal cells. Reprod Biomed Online. 2016;32:85-95 pubmed publisher
    ..Additionally, endometrial cells showed increased expression of homeobox HOXA10 and HOXA11 and LIFR, which are known to be involved in endometrial embryo receptivity...
  37. Wang L, Li J, Zhao H, Hu J, Ping Y, Li F, et al. Identifying the crosstalk of dysfunctional pathways mediated by lncRNAs in breast cancer subtypes. Mol Biosyst. 2016;12:711-20 pubmed publisher
    ..As an example, the low expression of LIFR-AS1 was associated with poor survival in LumB subtype, and its cooperated genes IL1R and TGFBR located at the most ..
  38. Shao Y, Li Y, Jiang L, Pan J, He Y, Dou X. Identification of pesticide varieties by detecting characteristics of Chlorella pyrenoidosa using Visible/Near infrared hyperspectral imaging and Raman microspectroscopy technology. Water Res. 2016;104:432-440 pubmed publisher
    ..The sensitive wavelengths (SWs) which are related to algae's pigment were chosen, and a model of LDA was established with the correct ..
  39. Tamminen J, Lambon Ralph M, Lewis P. Targeted memory reactivation of newly learned words during sleep triggers REM-mediated integration of new memories and existing knowledge. Neurobiol Learn Mem. 2017;137:77-82 pubmed publisher
    ..We used targeted memory reactivation (TMR) during slow-wave sleep (SWS) to selectively cue reactivation of newly learned spoken words...
  40. Yordanova J, Kolev V, Wagner U, Verleger R. Covert reorganization of implicit task representations by slow wave sleep. PLoS ONE. 2009;4:e5675 pubmed publisher
    There is evidence that slow wave sleep (SWS) promotes the consolidation of memories that are subserved by mediotemporal- and hippocampo-cortical neural networks...
  41. Leger D, Debellemaniere E, Rabat A, Bayon V, Benchenane K, Chennaoui M. Slow-wave sleep: From the cell to the clinic. Sleep Med Rev. 2018;41:113-132 pubmed publisher
    In recent decades, increasing evidence has positioned slow-wave sleep (SWS) as a major actor in neurophysiological phenomena such as glucose metabolism, hormone release, immunity and memory...
  42. Luo Q, Wang C, Jin G, Gu D, Wang N, Song J, et al. LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway. Carcinogenesis. 2015;36:1201-12 pubmed publisher
    ..In the present study, decreased expression of leukemia inhibitory factor receptor (LIFR) was demonstrated in HCC, and its expression levels were even lower in HCC with metastasis...
  43. Morton S, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, et al. Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. Oncotarget. 2015;6:26052-64 pubmed publisher
    ..To investigate the role of LIF in cholangiocarcinoma, we evaluated the expression of LIF and its receptor (LIFR) in human samples...
  44. Snyder E, Ma J, Svetnik V, Connor K, Lines C, Michelson D, et al. Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data. Sleep Med. 2016;19:93-100 pubmed publisher
    ..Effects on non-REM sleep stages 1 (N1), 2 (N2), 3 (N3)/slow wave sleep (SWS), and REM sleep were evaluated. A power spectral analysis of non-REM sleep was also performed...
  45. Finan P, Quartana P, Remeniuk B, Garland E, Rhudy J, Hand M, et al. Partial Sleep Deprivation Attenuates the Positive Affective System: Effects Across Multiple Measurement Modalities. Sleep. 2017;40: pubmed publisher
    ..state and that those effects may be mediated by changes in electroencepholographically measured slow wave sleep (SWS). In the present study, we extend those preliminary findings using multiple measures of affective functioning...
  46. Cho Y, Chang X, Park I, Yamashita K, Shao C, Ha P, et al. Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol. 2011;39:337-44 pubmed publisher
    ..An IL-6-type cytokine receptor, leukemia inhibitory factor receptor (LIFR), is a component of cell-surface receptor complexes for multifunctional cytokines such as LIF...
  47. Lyamin O, Pavlova I, Kosenko P, Mukhametov L, Siegel J. Regional differences in cortical electroencephalogram (EEG) slow wave activity and interhemispheric EEG asymmetry in the fur seal. J Sleep Res. 2012;21:603-11 pubmed publisher
    Slow wave sleep (SWS) in the northern fur seal (Callorhinus ursinus) is characterized by a highly expressed interhemispheric electroencephalogram (EEG) asymmetry, called 'unihemispheric' or 'asymmetrical' SWS...
  48. Santostasi G, Malkani R, Riedner B, Bellesi M, Tononi G, Paller K, et al. Phase-locked loop for precisely timed acoustic stimulation during sleep. J Neurosci Methods. 2016;259:101-114 pubmed publisher
    ..We describe a strategy for enhancing slow-wave sleep (SWS) by stimulating the sleeping brain with periodic acoustic stimuli that produce resonance in the form of enhanced ..
  49. Chang A, Bjonnes A, Aeschbach D, Buxton O, Gooley J, Anderson C, et al. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016;33:561-73 pubmed publisher
    ..97 years) of European ancestry. A common variant in Period2 (PER2) was associated with 20 min less slow-wave sleep (SWS) in carriers of the minor allele than in noncarriers, representing a 22% reduction in SWS duration...
  50. Zhou H, Yang X, Cui H, Tang T, Zhong J, Luo J, et al. Leukemia Inhibitory Factor Contributes to Reactive Astrogliosis via Activation of Signal Transducer and Activator of Transcription 3 Signaling after Intracerebral Hemorrhage in Rats. J Neurotrauma. 2017;34:1658-1665 pubmed publisher
    ..The expression of GFAP, LIF, LIF receptor (LIFR), glycoprotein 130 (gp130), and phospho-STAT3 (p-STAT3) was evaluated by immunohistochemistry and Western ..
  51. Sopp M, Michael T, Weeß H, Mecklinger A. Remembering specific features of emotional events across time: The role of REM sleep and prefrontal theta oscillations. Cogn Affect Behav Neurosci. 2017;17:1186-1209 pubmed publisher
    ..current study tested the effects of putative consolidation processes emerging during REM sleep and slow wave sleep (SWS) on item and source memory of negative and neutral images, respectively...
  52. Pothier K, Gagnon C, Fraser S, Lussier M, Desjardins Crépeau L, Berryman N, et al. A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. Aging Clin Exp Res. 2018;30:921-925 pubmed publisher
    Spontaneous walking speed (SWS) is one of the most important indicators of health in older adults...
  53. He W, Gong K, Zhu G, Smith D, Ip N. Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro. FEBS Lett. 2002;514:214-8 pubmed
    ..functional receptor complex of CNTF is composed of the CNTF receptor alpha (CNTFR), gp130 and the leukemia inhibitory factor receptor (LIFR). Three regions on CNTF have been identified as binding sites for its receptors...
  54. Iorns E, Ward T, Dean S, Jegg A, Thomas D, Murugaesu N, et al. Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor. Breast Cancer Res Treat. 2012;135:79-91 pubmed publisher
    ..genes including TP53 and MNT, as well as several novel candidate tumor suppressor genes including leukemia inhibitory factor receptor (LIFR)...
  55. Shi Y, Han Y, Su Y, Yang J, Yu Y. Silencing of Cholinergic Basal Forebrain Neurons Using Archaerhodopsin Prolongs Slow-Wave Sleep in Mice. PLoS ONE. 2015;10:e0130130 pubmed publisher
    ..previous study showed that activation of cholinergic BF neurons alone is sufficient to suppress slow-wave sleep (SWS) and promote wakefulness and rapid-eye-movement (REM) sleep...
  56. Westermann J, Lange T, Textor J, Born J. System consolidation during sleep - a common principle underlying psychological and immunological memory formation. Trends Neurosci. 2015;38:585-97 pubmed publisher
    ..In the psychological domain, neuronal reactivation of declarative memory during slow-wave sleep (SWS) promotes the redistribution of representations initially stored in hippocampal circuitry to extra-hippocampal ..
  57. Perkinson Gloor N, Hagmann von Arx P, Brand S, Holsboer Trachsler E, Grob A, Weber P, et al. Intraindividual long-term stability of sleep electroencephalography in school-aged children. Sleep Med. 2015;16:1348-1351 pubmed publisher
    ..001) for total sleep time (TST; intraclass correlation coefficient [ICC] = 0.65), slow wave sleep (SWS; min, %: ICC = 0.49), and stage 2 sleep (min; ICC = 0...
  58. Brito R, Pinheiro H, Ferreira F, Matos J, Pinheiro A, Lourenço N. Calibration Transfer Between a Bench Scanning and a Submersible Diode Array Spectrophotometer for In Situ Wastewater Quality Monitoring in Sewer Systems. Appl Spectrosc. 2016;70:443-54 pubmed publisher
    ..in situ, was assessed using three procedures: slope and bias correction (SBC); single wavelength standardization (SWS) on mean spectra; and local centering (LC)...
  59. Cobine C, Hannah E, Zhu M, Lyle H, Rock J, Sanders K, et al. ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter. J Physiol. 2017;595:2021-2041 pubmed publisher
    ..We examined the hypothesis that tone depends upon electrical slow waves (SWs) initiated in intramuscular interstitial cells of Cajal (ICC-IM) by activation of Ca2+ -activated Cl..
  60. Lodwick D, Dienhart M, Cooper J, Fung B, Lopez J, Smith S, et al. A pilot study of ultrasound elastography as a non-invasive method to monitor liver disease in children with short bowel syndrome. J Pediatr Surg. 2017;52:962-965 pubmed publisher
    ..study included pediatric patients with SBS who underwent ultrasound with ARFI measurements of shear wave speed (SWS) and liver biopsy within 30days of each other between 12/2014-9/2015...
  61. Sood D, Rathore A, Sood I, Kumar D, Sood N. Long-term intraocular pressure after combined trabeculotomy-trabeculectomy in glaucoma associated with Sturge-Weber syndrome. Eur J Ophthalmol. 2017;: pubmed publisher
    Vision loss in Sturge-Weber syndrome (SWS), a rare congenital disorder, is primarily due to glaucoma.
  62. Poliak N, Rainey A. Concurrent Sturge-Weber syndrome, facial infantile hemangioma, and cutis marmorata telangiectatica congenita. Cutis. 2017;100:252-254 pubmed
    We present a unique case of 3 vascular malformations-Sturge-Weber syndrome (SWS), facial infantile hemangioma (IH), and cutis marmorata telangiectatica congenita (CMTC)-with dermatologic manifestations presenting in the same patient...
  63. Harrington M, Johnson J, Croom H, Pennington K, Durrant S. The influence of REM sleep and SWS on emotional memory consolidation in participants reporting depressive symptoms. Cortex. 2018;99:281-295 pubmed publisher
    ..Slow-Wave Sleep (SWS) is typically associated with the consolidation of non-emotional memories...
  64. Gerashchenko D, Schmidt M, Zielinski M, Moore M, Wisor J. Sleep State Dependence of Optogenetically evoked Responses in Neuronal Nitric Oxide Synthase-positive Cells of the Cerebral Cortex. Neuroscience. 2018;379:189-201 pubmed publisher
    Slow-wave activity (SWA) in the electroencephalogram during slow-wave sleep (SWS) varies as a function of sleep-wake history...
  65. Varin C, Rancillac A, Geoffroy H, Arthaud S, Fort P, Gallopin T. Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism. J Neurosci. 2015;35:9900-11 pubmed publisher
    ..the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS)...
  66. Kang D, Ding M, Topchiy I, Shifflett L, Kocsis B. Theta-rhythmic drive between medial septum and hippocampus in slow-wave sleep and microarousal: a Granger causality analysis. J Neurophysiol. 2015;114:2797-803 pubmed publisher
    ..study used Granger causality (GC) to examine the interaction patterns between MS and HIPP in slow-wave sleep (SWS, a nontheta state) and during its short interruptions called microarousals (a transient theta state)...
  67. Abdolrahimzadeh S, Scavella V, Battaglia D, Recupero S. Spectral Domain Optical Coherence Tomography of Choroidal and Outer Retinal Layer Thickness in the Sturge Weber Syndrome. Curr Eye Res. 2016;41:1614-1617 pubmed
    To evaluate choroidal thickness and its effect on the outer retinal layers in patients with Sturge Weber syndrome (SWS)...
  68. Lord N, Plimpton R, Sharkey C, Suvorov A, Lelito J, Willardson B, et al. A cure for the blues: opsin duplication and subfunctionalization for short-wavelength sensitivity in jewel beetles (Coleoptera: Buprestidae). BMC Evol Biol. 2016;16:107 pubmed publisher
    ..Previous work has demonstrated that beetles appear to lack the short-wavelength-sensitive (SWS) opsin class that typically confers sensitivity to the "blue" region of the light spectrum...
  69. Uchino H, Kong V, Oosthuizen G, Bruce J, Bekker W, Laing G, et al. Can We Train Military Surgeons in a Civilian Trauma Center?. World J Surg. 2018;42:26-31 pubmed publisher
    ..There were 4974 cases of penetrating trauma, of which 3820 (77%) were stab wounds (SWs), 1006 (20%) gunshot wounds (GSWs) and the remaining 148 (3%) were animal injuries...
  70. Celebi S, Alagoz G, Aykan U. Ocular findings in Sturge-Weber syndrome. Eur J Ophthalmol. 2000;10:239-43 pubmed
    We reviewed the rare ocular findings of Sturge-Weber syndrome (SWS) and the results of implantation of the Ahmed valve in cases associated with glaucoma.
  71. Okamura Y, Nomoto S, Kanda M, Li Q, Nishikawa Y, Sugimoto H, et al. Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array. Cancer Lett. 2010;289:170-7 pubmed publisher
    ..b>Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47...
  72. Wei M, Yang Q, Xu Q, Zhang X, Li Y, Gu J, et al. Multi-wavelength lenses for terahertz surface wave. Opt Express. 2017;25:24872-24879 pubmed publisher
    ..The structure proposed here cannot only couple the terahertz wave from free space to SWs, but also control its propagation...
  73. Gearing D, Druck T, Huebner K, Overhauser J, Gilbert D, Copeland N, et al. The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13. Genomics. 1993;18:148-50 pubmed
    The leukemia inhibitory factor receptor (LIFR) gene was localized to human chromosome 5p12-p13 by somatic cell hybrid analysis...
  74. Edeline J, Manunta Y, Hennevin E. Auditory thalamus neurons during sleep: changes in frequency selectivity, threshold, and receptive field size. J Neurophysiol. 2000;84:934-52 pubmed
    ..the state of vigilance of an unanesthetized animal naturally fluctuates among wakefulness (W), slow-wave sleep (SWS), and paradoxical sleep (PS)...
  75. Timmermann A, Küster A, Kurth I, Heinrich P, Muller Newen G. A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor. Eur J Biochem. 2002;269:2716-26 pubmed
    ..in response to IL-6 and IL-11 or forms heterodimers with the leukemia inhibitory factor (LIF) receptor (LIFR) in response to LIF, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) or ..
  76. Plun Favreau H, Perret D, Diveu C, Froger J, Chevalier S, Lelievre E, et al. Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. J Biol Chem. 2003;278:27169-79 pubmed
    ..M (OSM) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp130 and LIF receptor (LIFR)...
  77. Buckley T, Schatzberg A. Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation. Am J Geriatr Psychiatry. 2005;13:344-52 pubmed
    ..procedural memory dysfunction, may be partially reversible by instituting methods to augment slow-wave sleep (SWS)...
  78. Mizukami M, Yoshikawa K, Kawamoto H, Sano A, Koseki K, Asakwa Y, et al. Gait training of subacute stroke patients using a hybrid assistive limb: a pilot study. Disabil Rehabil Assist Technol. 2017;12:197-204 pubmed
    ..The 10-m maximum walking speed (MWS), self-selected walking speed (SWS) and 2-min-walk test (2MT) without HAL were used as primary outcome measures to determine the effects of training...
  79. Sukeena J, Galicia C, Wilson J, McGinn T, Boughman J, Robison B, et al. Characterization and Evolution of the Spotted Gar Retina. J Exp Zool B Mol Dev Evol. 2016;326:403-421 pubmed publisher
    ..We report that the gar has a preponderance of predicted short-wavelength shifted (SWS) opsin genes, including a duplicated set of SWS1 (ultraviolet) sensitive opsin encoding genes, a SWS2 (blue) opsin ..
  80. Huang L, Couto J, Pinto A, Alexandrescu S, Madsen J, Greene A, et al. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017;67:59-63 pubmed publisher
    Sturge-Weber syndrome (SWS) is a rare congenital neurocutaneous disorder characterized by facial and extracraniofacial capillary malformations and capillary-venule malformations in the leptomeninges. A somatic mosaic mutation in GNAQ (c...
  81. Zhou B, Wang D, Ren W, Li X, He Y, Liu B, et al. Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis. Sci Rep. 2017;7:7036 pubmed publisher
    ..0%, and a negative predictive value (NPV) of 97.5%. Compared with using the standard deviation of shear wave speed (SWSSD) alone, SWSSD combined with QSWP increased the sensitivity from 75.8% to 93...
  82. Wu Y, Yu R, Lin X, Guo W. [Sturge-Weber syndrome in port-wine stain patients: a retrospective study on the clinical features and screening strategy]. Zhonghua Yan Ke Za Zhi. 2017;53:753-757 pubmed publisher
    b>Objective: To investigate the clinical characteristics of Sturge-Weber syndrome (SWS) in the patients with Port-wine stain (PWS)...
  83. Takayama O, Bogdanov A, Lavrinenko A. Photonic surface waves on metamaterial interfaces. J Phys Condens Matter. 2017;29:463001 pubmed publisher
    ..This article reviews the recent progress and development in the physics of SWs localized at metamaterial interfaces, as well as bulk media in order to provide broader perspectives on optical ..
  84. Halovic S, Kroos C. Walking my way? Walker gender and display format Confounds the perception of specific emotions. Hum Mov Sci. 2018;57:461-477 pubmed publisher
    ..in PL (Female: [Happy?=?Sad?=?Fear?=?Anger]?>?Neutral; Male: Fear?=?Sad?=?[Happy?>?Anger]?>?Neutral) and SWs (Female: Happy?=?Sad?=?Anger?=?Fear?=?Neutral; Male: [Happy?=?Sad?=?Anger]?>?[Fear?=?Neutral]; Ambiguous: [[..
  85. Lewin M, Ilina M, Betz J, Masiello K, Hui M, Wilson D, et al. Developmental Ethanol-Induced Sleep Fragmentation, Behavioral Hyperactivity, Cognitive Impairment and Parvalbumin Cell Loss are Prevented by Lithium Co-treatment. Neuroscience. 2018;369:269-277 pubmed publisher
    ..impairment in adult mice exposed at postnatal day 7 (P7) to ethanol (EtOH) correlate with slow-wave sleep (SWS) fragmentation (Wilson et al., 2016)...
  86. Schiemann W, Graves L, Baumann H, Morella K, Gearing D, Nielsen M, et al. Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. Proc Natl Acad Sci U S A. 1995;92:5361-5 pubmed
    ..Indeed, phosphorylation of the cytoplasmic domain of the low-affinity LIF receptor alpha-subunit (LIFR) in Mono Q-fractionated, LIF-stimulated 3T3-L1 extracts occurred only in those fractions ..
  87. Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole D, et al. High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Bone. 2010;47:975-81 pubmed publisher
    ..The results reported in this study suggest a role for CSF3R in the determination of bone density in women. ..
  88. Conrady C, Zheng M, Van Rooijen N, Drevets D, Royer D, Alleman A, et al. Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013;190:2807-17 pubmed publisher
    ..Our results implicate lateral ventricle enlargement as a major cause of mortality in mice and speculate such an event transpires in a subpopulation of human HSV encephalitic patients. ..
  89. Li X, Xu H, Bo X, Liu B, Huang X, Li D, et al. Value of Virtual Touch Tissue Imaging Quantification for Evaluation of Ultrasound Breast Imaging-Reporting and Data System Category 4 Lesions. Ultrasound Med Biol. 2016;42:2050-7 pubmed publisher
    ..differences were found between benign and malignant lesions in EI score, VTI score and shear wave speed (SWS) on VTIQ (both p < 0.05). The cut-off values were EI score ?4, VTI score ?4 and SWS ?3.49 m/s, respectively...
  90. Sasso M, Liu Y, Aron Wisnewsky J, Bouillot J, Abdennour M, Clet M, et al. AdipoScan: A Novel Transient Elastography-Based Tool Used to Non-Invasively Assess Subcutaneous Adipose Tissue Shear Wave Speed in Obesity. Ultrasound Med Biol. 2016;42:2401-13 pubmed publisher
    ..a novel device called the AdipoScan that was adapted from the FibroScan to specifically assess shear wave speed (SWS) in human abdominal subcutaneous adipose tissue (scAT)...
  91. Tzschätzsch H, Sack I, Marticorena Garcia S, Ipek Ugay S, Braun J, Hamm B, et al. Time-Harmonic Elastography of the Liver is Sensitive to Intrahepatic Pressure Gradient and Liver Decompression after Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation. Ultrasound Med Biol. 2017;43:595-600 pubmed publisher
    We investigated the correlation between hepatic venous pressure gradient (HVPG) and liver shear wave speed (SWS) measured by multi-frequency time-harmonic ultrasound elastography (THE) before and after transjugular intrahepatic ..
  92. Anaclet C, Griffith K, Fuller P. Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine. Neuropsychopharmacology. 2018;43:415-425 pubmed publisher
    ..activation of GABA-releasing parafacial zone (PZVgat) neurons in behaving mice produces slow-wave-sleep (SWS), even in the absence of sleep deficit, suggesting that these neurons may represent, at least in part, a key ..