LIF

Summary

Gene Symbol: LIF
Description: LIF, interleukin 6 family cytokine
Alias: CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, D factor, cholinergic differentiation factor, differentiation inhibitory activity, differentiation-inducing factor, differentiation-stimulating factor, hepatocyte-stimulating factor III, human interleukin in DA cells, melanoma-derived LPL inhibitor
Species: human
Products:     LIF

Top Publications

  1. Williams R, Hilton D, Pease S, Willson T, Stewart C, Gearing D, et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature. 1988;336:684-7 pubmed
    ..phenotype in vitro requires the presence of a feeder layer of fibroblasts or of a soluble factor, differentiation inhibitory activity (DIA) produced by a number of sources; in the absence of DIA the ES cells differentiate into a wide ..
  2. Hatzi E, Murphy C, Zoephel A, Ahorn H, Tontsch U, Bamberger A, et al. N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma. Eur J Biochem. 2002;269:3732-41 pubmed
    ..Here, we report that experimental N-Myc overexpression results in down-regulation of leukemia inhibitory factor (LIF), a modulator of endothelial cell proliferation...
  3. Steck T, Giess R, Suetterlin M, Bolland M, Wiest S, Poehls U, et al. Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2004;112:69-73 pubmed
    Leukaemia inhibitory factor (LIF) plays a central role in the control of implantation...
  4. Fan Z, Bau B, Yang H, Aigner T. IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine. 2004;28:17-24 pubmed
    ..a catabolic response in articular chondrocytes it also strongly induces synergistic mediators such as leukemia inhibitory factor (LIF) and interleukin-6 (IL-6). The molecular basis of this is so far hardly understood...
  5. Poehlmann T, Fitzgerald J, Meissner A, Wengenmayer T, Schleussner E, Friedrich K, et al. Trophoblast invasion: tuning through LIF, signalling via Stat3. Placenta. 2005;26 Suppl A:S37-41 pubmed
    ..Stat3 activation is necessary in the invasive phenotype of trophoblast cells and can be controlled via Leukemia Inhibitory Factor (LIF)...
  6. Mikolajczyk M, Wirstlein P, Skrzypczak J. Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis. Hum Reprod. 2006;21:3054-8 pubmed
    ..Interleukin 11 (IL-11) and leukaemia-inhibitory factor (LIF) are factors associated with implantation window in human eutopic endometrium...
  7. Guney M, Erdemoglu E, Oral B, Karahan N, Mungan T. Leukemia inhibitory factor (LIF) is immunohistochemically localized in tubal ectopic pregnancy. Acta Histochem. 2008;110:319-23 pubmed publisher
    b>Leukemia inhibitory factor (LIF) is essential for implantation of the embryo in the endometrium. It is not clear whether the blastocyst requires expression of LIF for implantation into tissues other than endometrium...
  8. Marwood M, Visser K, Salamonsen L, Dimitriadis E. Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation. Endocrinology. 2009;150:2915-23 pubmed publisher
    ..IL-11 and leukemia inhibitory factor (LIF), two IL-6 family cytokines, are produced by the endometrium and are absolutely required for ..
  9. Trouillas M, Saucourt C, Guillotin B, Gauthereau X, Taupin J, Moreau J, et al. The LIF cytokine: towards adulthood. Eur Cytokine Netw. 2009;20:51-62 pubmed publisher
    The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data...

More Information

Publications130 found, 100 shown here

  1. Arthan D, Hong S, Park J. Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. Cancer Lett. 2010;297:31-41 pubmed publisher
    ..Activation of the Ras/Raf/MEK/ERK pathway can lead to growth arrest by secreting leukemia inhibitory factor (LIF) in MTC cells harboring a RET receptor domain mutation...
  2. Shuya L, Menkhorst E, Yap J, Li P, Lane N, Dimitriadis E. Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice. PLoS ONE. 2011;6:e25288 pubmed publisher
    ..Here, we investigated the role of leukemia inhibitory factor (LIF) in human and murine decidualization...
  3. Nakajima S, Tanaka T, Umesaki N, Ishiko O. Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells. Int J Mol Med. 2003;11:353-6 pubmed
    b>Leukemia inhibitory factor (LIF) is produced locally in decidual tissues, but its direct effects on endometrial stromal cells have not been well characterized...
  4. Chen H, Chao K, Shew J, Yang Y, Ho H. Expression of leukemia inhibitory factor and its receptor is not altered in the decidua and chorionic villi of human anembryonic pregnancy. Hum Reprod. 2004;19:1647-54 pubmed
    Uterine expression of leukemia inhibitory factor (LIF) is absolutely essential for mouse, and critical for human, embryo implantation. However LIF is not required for post-implantation development of mouse embryo...
  5. Kralickova M, Sima R, Vanecek T, Sima P, Rokyta Z, Ulcova Gallova Z, et al. Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients. Eur J Obstet Gynecol Reprod Biol. 2006;127:231-5 pubmed
    b>Leukemia inhibitory factor (LIF) is one of the key cytokines in the embryo implantation regulation...
  6. Tapia A, Salamonsen L, Manuelpillai U, Dimitriadis E. Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2. Hum Reprod. 2008;23:1724-32 pubmed publisher
    b>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that is essential for blastocyst implantation in mice. It has been suggested that LIF may play a role in human first trimester extravillous trophoblast (EVT) invasion...
  7. Paiva P, Menkhorst E, Salamonsen L, Dimitriadis E. Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. Cytokine Growth Factor Rev. 2009;20:319-28 pubmed publisher
    ..b>Leukemia inhibitory factor (LIF) and interleukin-11 (IL11) have key roles during implantation...
  8. Hyc A, Moskalewski S, Osiecka Iwan A. Influence of cartilage interstitial fluid on the mRNA levels of matrix proteins, cytokines, metalloproteases and their inhibitors in synovial membrane. Int J Mol Med. 2016;38:937-42 pubmed publisher
    ..protein 7 (BMP7), macrophage (M)-colony-stimulating factor (CSF), granulocyte (G)-CSF and leukemia inhibitory factor (LIF)...
  9. Satar B, Hidir Y, Serdar M, Kucuktag Z, Ural A, Avcu F, et al. Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells. Cytotherapy. 2012;14:522-8 pubmed publisher
    ..neurotrophic factor (CNTF), neurotrophin (NT)-3, NT-4, glial cell-derived neurotropic factor (GDNF), leukemia inhibitory factor (LIF), basic fibroblast growth factor (FGF)-2, insulin-like growth factor (IGF)-1, platelet-derived ..
  10. Marecek Z, Bruha R. [Wilsons disease]. Vnitr Lek. 2013;59:578-83 pubmed
    ..The dia-gnosis is based on clinical and laboratory assessments (neurological signs, liver lesions, low ceruloplasmin, ..
  11. Tang H, Ho H, Wu P, Chen S, Kuypers F, Cheng M, et al. Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance. Antioxid Redox Signal. 2015;22:744-59 pubmed publisher
    ..We used diamide (DIA) to mimic drug-induced oxidative stress and studied how these drugs affect cellular metabolism using a metabolomic ..
  12. Cain J, Dale A, Niewold P, Klare W, Man L, White M, et al. Proteomics Reveals Multiple Phenotypes Associated with N-linked Glycosylation in Campylobacter jejuni. Mol Cell Proteomics. 2019;18:715-734 pubmed publisher
    ..liquid chromatography/tandem mass spectrometry (LC-MS/MS) and validation using data independent acquisition (DIA-SWATH-MS). We quantified 1359 proteins corresponding to ∼84% of the C...
  13. Martin J, Giedroc D. Functional Determinants of Metal Ion Transport and Selectivity in Paralogous Cation Diffusion Facilitator Transporters CzcD and MntE in Streptococcus pneumoniae. J Bacteriol. 2016;198:1066-76 pubmed publisher
    ..Streptococcus pneumoniae expresses two homologous CDF efflux transporters, MntE and CzcD...
  14. Lainez N, Coss D. Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. Neuroendocrinology. 2019;: pubmed publisher
    ..b>Leukemia inhibitory factor (LIF) in particular represses GnRH expression in GT1-7 cells, while other cytokines do not...
  15. Sims N. Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption. Int J Biochem Cell Biol. 2016;79:14-23 pubmed publisher
    ..CT-1, OSM and LIF suppress marrow adipogenesis by shifting commitment of pluripotent precursors towards osteoblast differentiation...
  16. Liu P, Liu C. Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling. J Biomed Sci. 2016;23:90 pubmed
    ..no preferential distribution in any particular type of neural cells, but observed scattered EDNs of 60-150 nm (dia) in lysosomes. In the acute paradigm, mice pretreated with miD2861 (1.2 mmol/kg, i.p...
  17. Zhao J, Zhang Q, Wang Y, Li Y. Uterine infusion with bone marrow mesenchymal stem cells improves endometrium thickness in a rat model of thin endometrium. Reprod Sci. 2015;22:181-8 pubmed publisher
    ..lining and exhibited higher expression of cytokeratin, vimentin, integrin αγβ3, and leukaemia inhibitor factor (LIF) than that of the control group (P < .05)...
  18. Wu Q, Xu H, Yang J, Li Z, Fu T, Du H, et al. [Effect of GnRHa controlled ovarian hyperstimulation on mouse embryo implantation and its mechanism]. Sheng Li Xue Bao. 2018;70:489-496 pubmed
    ..The protein expression levels of endometrial leukemia inhibitory factor (LIF), phosphorylated signal transducer and activator of transcription 3 (p-STAT3), heparin-binding ..
  19. Barcza Stockler Pinto M, Carrero J, De Carvalho Cardoso Weide L, Franciscato Cozzolino S, Mafra D. EFFECT OF SELENIUM SUPPLEMENTATION VIA BRAZIL NUT (BERTHOLLETIA EXCELSA, HBK) ON THYROID HORMONES LEVELS IN HEMODIALYSIS PATIENTS: A PILOT STUDY. Nutr Hosp. 2015;32:1808-12 pubmed publisher
    ..anos, dialisis vendimia 62,0 (8,0 - 207,0 meses)), que recibieron una nuez (≈ 5, promedio 58,1 mg Se/g) por dia durante tres meses...
  20. Wang H, Bao Q, Yi H, Xia Q. The evaluation of embryotoxicity of Ligusticum chuanxiong on mice and embryonic stem cells. J Ethnopharmacol. 2019;:111895 pubmed publisher
    ..After removal of inhibiting factor (LIF), mouse embryonic stem cells spontaneously differentiated into cardiomyocytes, the expression of specific myosin ..
  21. Blitek A, Szymanska M. Regulation of expression and role of peroxisome proliferator-activated receptors (PPARs) in luminal epithelial and stromal cells of the porcine endometrium. Theriogenology. 2019;127:88-101 pubmed publisher
    ..down-regulated the expression of genes encoding amino acid transporter 1 (SLC38A1), leukemia inhibitory factor (LIF) and enzymes involved in PG synthesis (P < 0.05)...
  22. Fortuoso B, Gebert R, Griss L, Glombovisky P, Cazarotto C, Rampazzo L, et al. Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic product in newborn lambs. Microb Pathog. 2019;127:347-351 pubmed publisher
    ..Therefore, the objective of the present study was to verify the administration of the homeopathic product (Dia 100®) in newborn and bottle-fed lambs, in order to prevent or minimize the occurrence of diarrhea...
  23. Sharova V, Izvolskaia M, Zakharova L. Lipopolysaccharide-induced maternal inflammation affects the gonadotropin-releasing hormone neuron development in fetal mice. Neuroimmunomodulation. 2015;22:222-32 pubmed publisher
    ..cytokines interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, tumor necrosis factor (TNF)-α and leukemia inhibitory factor (LIF) were measured with the cytometric bead and ELISA array method in the maternal and fetal blood, ..
  24. Turner A, Ong C, Gillen C, Davies M, West N, McEwan A, et al. Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. MBio. 2015;6: pubmed publisher
    ..A Streptococcus, mutation of the mntE locus, which encodes a transport protein of the cation diffusion facilitator (CDF) family, results in accumulation of manganese and sensitivity to this transition metal ion...
  25. Dohare P, Zia M, Ahmed E, Ahmed A, Yadala V, Schober A, et al. AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage. J Neurosci. 2016;36:3363-77 pubmed publisher
    ..NBQX administration also reduced the population of apoptotic OPCs, levels of several cytokines (TNF?, IL-?, IL-6, LIF), and the density of Iba1(+) microglia in pups with IVH...
  26. Steelman A, Zhou Y, Koito H, Kim S, Payne H, Lu Q, et al. Activation of oligodendroglial Stat3 is required for efficient remyelination. Neurobiol Dis. 2016;91:336-46 pubmed publisher
    ..Ciliary neurotrophic factor (CNTF) family cytokines such as leukemia inhibitory factor (LIF) and interleukin 11 (IL-11) are known to promote oligodendrocyte maturation and remyelination in ..
  27. Li J, Levitan B, Gomez Jimenez S, Kültz D. Development of a Gill Assay Library for Ecological Proteomics of Threespine Sticklebacks (Gasterosteus aculeatus). Mol Cell Proteomics. 2018;17:2146-2163 pubmed publisher
    A data-independent acquisition (DIA) assay library for quantitative analyses of proteome dynamics has been developed for gills of threespine sticklebacks (Gasterosteus aculeatus)...
  28. Kumar B, Chandran B. KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses. 2016;8: pubmed
    ..of host signal pathways which results in the simultaneous induction of FAK, Src, PI3-K, Rho-GTPase, ROS, Dia-2, PKC ?, c-Cbl, CIB1, Crk, p130Cas and GEF-C3G signal and adaptor molecules that play critical roles in the ..
  29. Milesi M, Varayoud J, Ramos J, Luque E. Uterine ERα epigenetic modifications are induced by the endocrine disruptor endosulfan in female rats with impaired fertility. Mol Cell Endocrinol. 2017;454:1-11 pubmed publisher
    ..e. mucin-1 (MUC-1), insulin-like growth factor-1 (IGF-1), and leukemia inhibitory factor (LIF), was assessed by real time RT-PCR...
  30. Yeruva L, Spencer N, Saraf M, Hennings L, Bowlin A, Cleves M, et al. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016;16:40 pubmed publisher
    ..In ileum, formula diet induced significant up-regulation of AMCFII, IL-8, IL-15, VEGFA, LIF, FASL, CXCL11, CCL4, CCL25 and down-regulation of IL-6, IL-9, IL-10, IL-27, IFNA4, CSF3, LOC100152038, and ..
  31. Gross J, Schwinn A, Schmitz Hsu F, Menzi F, Drogemuller C, Albrecht C, et al. Rapid Communication: Cholesterol deficiency-associated APOB mutation impacts lipid metabolism in Holstein calves and breeding bulls. J Anim Sci. 2016;94:1761-6 pubmed publisher
    ..mutant genotype was absent, 36 bulls were heterozygous carriers (CDC), and 218 bulls were homozygous wild-type (CDF)...
  32. Doherty L, Taylor H. Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity. Fertil Steril. 2015;103:845-52 pubmed publisher
    ..Expression of BMP receptor types 1A, 1B, 2, as well as endometrial receptivity mediators HOXA10 and leukemia inhibitory factor (LIF). Enzyme-linked immunosorbent assay showed elevated TGF-β levels in LCM...
  33. Marechal A, Jarrosson F, Randon J, Dugas V, Demesmay C. In-line coupling of an aptamer based miniaturized monolithic affinity preconcentration unit with capillary electrophoresis and Laser Induced Fluorescence detection. J Chromatogr A. 2015;1406:109-17 pubmed publisher
    ..coupled to the end of the capillary used for capillary electrophoresis (CE) with laser induced fluorescence (LIF) detection...
  34. Goetz S, Rejzek M, Nepogodiev S, Field R. The impact of aminopyrene trisulfonate (APTS) label in acceptor glycan substrates for profiling plant pectin ?-galactosyltransferase activities. Carbohydr Res. 2016;433:97-105 pubmed publisher
    ..These studies demonstrate the potential of even very short glycan-APTS probes for assessing plant galactosyltransferase activities and the suitability CE-LIF for CAZyme profiling.
  35. Reyes Haro D, Labrada Moncada F, Varman D, Krüger J, Morales T, Miledi R, et al. Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus. Neural Plast. 2016;2016:2426413 pubmed publisher
    ..Dehydration-induced anorexia (DIA) is a murine model that mimics core features of this disorder, including severe weight loss due to voluntary ..
  36. Ting Y, Egertson J, Bollinger J, Searle B, Payne S, Noble W, et al. PECAN: library-free peptide detection for data-independent acquisition tandem mass spectrometry data. Nat Methods. 2017;14:903-908 pubmed publisher
    Data-independent acquisition (DIA) is an emerging mass spectrometry (MS)-based technique for unbiased and reproducible measurement of protein mixtures...
  37. Donnikov A, Shkurnikov M, Akimov E, Grebenyuk E, Khaustova S, Shahmatova E, et al. Effect of a six-hour marathon ultra-race on the levels of IL-6, LIF, and SCF. Bull Exp Biol Med. 2009;148:819-21 pubmed
    ..ultra-race (long aerobic work below the lactate threshold level) on the levels of IL-6, leukemia inhibiting factor (LIF), and stem cell growth factor (SCF) were studied...
  38. Kuphal S, Wallner S, Bosserhoff A. Impact of LIF (leukemia inhibitory factor) expression in malignant melanoma. Exp Mol Pathol. 2013;95:156-65 pubmed publisher
    b>Leukemia inhibitory factor (LIF) signaling regulates cellular processes to maintain the self-renewal and pluripotency of embryonic stem (ES) cells...
  39. Kaltwasser S, Schmitz L, Michel Schmidt R, Anspach L, Kirkpatrick C, Wessler I. Murine embryonic stem cell line CGR8 expresses all subtypes of muscarinic receptors and multiple nicotinic receptor subunits: Down-regulation of α4- and β4-subunits during early differentiation. Int Immunopharmacol. 2015;29:110-4 pubmed publisher
    ..subunits and muscarinic receptors was performed, when the stem cells were grown in the presence or absence of LIF, as the latter condition induces early differentiation...
  40. Patil R, Gaikwad S, More Y, Kulkarni M, Bhatt B, Moharil S. A new highly sensitive low-Z LiF-based OSL phosphor for radiation dosimetry. Radiat Prot Dosimetry. 2016;168:465-70 pubmed publisher
    ..The fast decay, good sensitivity, good linearity and its near tissue equivalence (Zeff ∼8.14) will make this phosphor suitable for radiation dosimetry particularly in personnel as well as in medical dosimetry. ..
  41. Cerón Ramírez P, Díaz Góngora J, Paredes Gutiérrez L, Rivera Montalvo T, Vega Carrillo H. Neutron H*(10) estimation and measurements around 18MV linac. Appl Radiat Isot. 2016;117:2-7 pubmed publisher
    ..out through neutron ambient dose monitors which include pairs of thermoluminescent dosimeters TLD 600 (6LiF: Mg, Ti) and TLD 700 (7LiF: Mg, Ti), which were placed inside a paraffin spheres...
  42. Lonski P, Keehan S, Siva S, Pham D, Franich R, Taylor M, et al. Out-of-field in vivo dosimetry using TLD in SABR for primary kidney cancer involving mixed photon fields. Phys Med. 2017;37:9-15 pubmed publisher
    To assess out-of-field dose using three different variants of LiF thermoluminescence dosimeters (TLD) for ten patients who underwent stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) and compare with ..
  43. Raicevic G, Najar M, Busser H, Crompot E, Bron D, Toungouz M, et al. Comparison and immunobiological characterization of retinoic acid inducible gene-I-like receptor expression in mesenchymal stromal cells. Sci Rep. 2017;7:2896 pubmed publisher
    ..Finally, the expression of IDO1 and LIF upon RLR activation indicate the increase of MSC immunomodulatory potential, especially in AT-MSCs...
  44. Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, et al. Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling. Proc Natl Acad Sci U S A. 2017;114:10113-10118 pubmed publisher
    ..embryonic stem cell pluripotency in a manner independent of the TGF-? receptors, yet dependent on the leukemia inhibitory factor (LIF) coreceptor glycoprotein 130 (gp130)...
  45. Zhang N, Tian M, Liu X, Yang L. Enzyme assay for d-amino acid oxidase using optically gated capillary electrophoresis-laser induced fluorescence detection. J Chromatogr A. 2018;1548:83-91 pubmed publisher
    ..In this study we presented the first application of optically gated capillary electrophoresis with LIF detection (OGCE-LIF) for efficient assay of DAAO activity...
  46. Schmelzer C, Harris R, Butler D, Yedinak C, Wagner K, Burton L. Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor. Arch Biochem Biophys. 1993;302:484-9 pubmed
    ..Additional peptides, generated by tryptic digestion of peptic fragments, allowed the assignments of three intrachain disulfide bonds (Cys-18 to Cys-131, Cys-12 to Cys-134, and Cys-60 to Cys-163). ..
  47. Dozio E, Ruscica M, Galliera E, Corsi M, Magni P. Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function. Curr Protein Pept Sci. 2009;10:577-84 pubmed
    ..focus the attention on four of these molecules, specifically leptin, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6)...
  48. Ellis L, Grant M, Hawksworth G, Weaver R. Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR(-)) rats. Toxicol In Vitro. 2014;28:1165-75 pubmed publisher
    ..Bi-phasic kinetics of transport of 5(6)-carboxydichlorofluorescein (CDF) at the canalicular membrane was demonstrated in Sprague Dawley (SD) and Wistar (W) rat hepatocytes...
  49. Oostra A, Smits E, de Leeuw D, Blom P, Michels J. On the short circuit resilience of organic solar cells: prediction and validation. Phys Chem Chem Phys. 2015;17:21501-6 pubmed publisher
    ..By studying charge transport across PSS-lithium fluoride/aluminum (LiF/Al) shunting junctions we show that this prerequisite is already met by applying a sufficiently thick (>1...
  50. Hu H, Asweto C, Wu J, Shi Y, Feng L, Yang X, et al. Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5. Chemosphere. 2017;183:589-598 pubmed publisher
    ..5-induced toxicity in HUVECs. Moreover, gene expression confirmation of LIF, BCL2L1, CSF3, HMOX1, RPS6, PFKFB, CAPN1, HSPBP1, MOGS, PREB, TUBB2A, GABARAP by qRT-PCR indicated that endocytosis ..
  51. Shimamura S, Kawai K, Odontuya D, Ichihashi T. A Comparison of Characteristic Properties and Qualitative Difference between Three Kinds of Triamcinolone Acetonide. Tokai J Exp Clin Med. 2017;42:67-70 pubmed
    ..It had a small mean particle dia (almost the same size as the newer form of MaQaid® and Kenacort-A)...
  52. Behrendt S, Buhringer G, Hofler M, Lieb R, Beesdo Baum K. Prediction of incidence and stability of alcohol use disorders by latent internalizing psychopathology risk profiles in adolescence and young adulthood. Drug Alcohol Depend. 2017;179:32-41 pubmed publisher
    ..DSM-IV mental disorders were assessed with the DIA-X/M-CIDI...
  53. Danish A, Lee S, Muller C. Quantification of green fluorescent protein-(GFP-) tagged membrane proteins by capillary gel electrophoresis. Analyst. 2017;142:3648-3655 pubmed publisher
    ..was developed employing capillary gel electrophoresis coupled to laser-induced fluorescence detection (CGE-LIF)...
  54. Tan F, Xu W, Hu X, Yu P, Zhang W. Highly Efficient Inverted Perovskite Solar Cells with CdSe QDs/LiF Electron Transporting Layer. Nanoscale Res Lett. 2017;12:614 pubmed publisher
    ..when using cadmium selenide (CdSe) quantum dots (QDs) as electron transporting layer (ETL) and lithium fluoride (LiF) as the buffer, with respect to the traditionally applied and high-cost [6,6]-phenyl-C61-butyric acid methyl ester (..
  55. Serafini P, Silva I, Smith G, Motta E, Rocha A, Baracat E. Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome. Reprod Biol Endocrinol. 2009;7:30 pubmed publisher
    ..Recently, we examined immunolabeling of leukemia inhibitory factor (LIF) in the endometrial tissue of 52 IVF patients, and found that LIF staining intensity was strongly ..
  56. Cao L, Liang S, Tan X, Meng J. [Capillary electrophoresis analysis for glyphosate, glufosinate and aminomethylphosphonic acid with laser-induced fluorescence detection]. Se Pu. 2012;30:1295-300 pubmed
    ..and aminomethylphosphonic acid by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). 5-(4,6-Dichlorotriazinyl) amino fluorescein (DTAF) was successfully applied to label the herbicides...
  57. Lombardi G, Sanchis Gomar F, Perego S, Sansoni V, Banfi G. Implications of exercise-induced adipo-myokines in bone metabolism. Endocrine. 2016;54:284-305 pubmed
    ..e., irisin, IL-6, LIF, IGF-I) which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, ..
  58. Imaizumi A, Onishi H, Yamasaki A, Kawamoto M, Umebayashi M, Morisaki T, et al. Hypoxic Conditions Promote Gemcitabine Sensitivity in a Pancreatic Cancer Stem Cell Line. Anticancer Res. 2016;36:653-7 pubmed
    ..We established a pancreatic cancer stem cell-rich cell line using TIG-1 feeder cells and leukemia inhibitory factor (LIF)-rich SNL76/7 conditioned medium...
  59. Bai S, Chang S, Duh J, Sung F, Su J, Chang M. Characterization of PCDD/Fs and dioxin-like PCBs emitted from two woodchip boilers in Taiwan. Chemosphere. 2017;189:284-290 pubmed publisher
    ..plants during normal operation are O8CDD, 1,2,3,4,6,7,8-H7CDD and 1,2,3,4,6,7,8-H7CDF, while major dl-PCBs are TeCB-77, PeCB-118 and PeCB-126...
  60. Yadav A, Gupta A, Steiner A, Boomishankar R. Mapping the Assembly of Metal-organic Cages into Complex Coordination Networks. Chemistry. 2017;: pubmed publisher
    ..Post-assembly reactions of the cubic cage with Fe(II) and Zn(II) ions produced cage-connected networks of dia and qtz topologies, respectively...
  61. Zhang X, Meng J, Zhao K, Chen X, Yang Z. Annotation and characterization of Cd-responsive metal transporter genes in rapeseed (Brassica napus). Biometals. 2018;31:107-121 pubmed publisher
    ..Based on the sequence identity, nine superfamilies including YSL, OPT, NRAMP, COPT, ZIP, CDF/MTP, HMA, MRP and PDR have been classified. RNA-sequencing profiled 202 non-redundant MTGs from B...
  62. Perrier d Hauterive S, Charlet Renard C, Dubois M, Berndt S, Goffin F, Foidart J, et al. Human endometrial leukemia inhibitory factor and interleukin-6: control of secretion by transforming growth factor-beta-related members. Neuroimmunomodulation. 2005;12:157-63 pubmed
    ..could intervene in the first steps of embryo implantation by modulating the secretion of proimplantatory leukemia inhibitory factor (LIF) and in the tolerance of the fetal graft by regulating proinflammatory interleukin (IL)-6 secretion ..
  63. Whitney M, Lee A, Ylostalo J, Zeitouni S, Tucker A, Gregory C. Leukemia inhibitory factor secretion is a predictor and indicator of early progenitor status in adult bone marrow stromal cells. Tissue Eng Part A. 2009;15:33-44 pubmed publisher
    ..Messenger RNA encoding the cytokine leukemia inhibitory factor (LIF) was identified as differentially expressed...
  64. Morse R, Allingham D, Stocks N. A phenomenological model of myelinated nerve with a dynamic threshold. J Theor Biol. 2015;382:386-96 pubmed publisher
    ..Phenomenological nerve models, such as leaky integrate-and-fire (LIF) models, have fewer parameters but have not been validated with a wide range of stimuli...
  65. Hand F, Harmon C, Elliott L, Caiazza F, Lavelle A, Maguire D, et al. Depleted polymorphonuclear leukocytes in human metastatic liver reflect an altered immune microenvironment associated with recurrent metastasis. Cancer Immunol Immunother. 2018;67:1041-1052 pubmed publisher
    ..001). IL-6, CXCL1, CXCL5, G-CSF, GM-CSF, VEGF, LIF, and CCL3 were higher in liver-bearing CRLM compared to donor tissue...
  66. Bamberger A, Jenatschke S, Schulte H, Ellebrecht I, Beil F, Bamberger C. Regulation of the human leukemia inhibitory factor gene by ETS transcription factors. Neuroimmunomodulation. 2004;11:10-9 pubmed
    b>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine mainly produced by activated T lymphocytes. We previously demonstrated that human Jurkat T lymphoma cells represent a valid model of LIF gene expression...
  67. Gu W, Prasadam I, Yu M, Zhang F, Ling P, Xiao Y, et al. Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. BMC Cancer. 2015;15:609 pubmed publisher
    ..In contrast, expression of self-renewal genes TGF-beta and LIF, as well as ESR signal pathways were not affected by the treatment...
  68. Shi Z, Pan Z, Zhang C, Zheng H. Syntheses, structures, and properties of six cobalt(II) complexes based on a tripodal tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine ligand. Dalton Trans. 2015;44:16854-64 pubmed publisher
    ..Complex 2 has a 2-fold interpenetrating 3D dia framework...
  69. Rousso T, Schejter E, Shilo B. Orchestrated content release from Drosophila glue-protein vesicles by a contractile actomyosin network. Nat Cell Biol. 2016;18:181-90 pubmed publisher
    ..We identify the Formin family protein Diaphanous (Dia) as the main actin nucleator involved in generating this structure, and uncover Rho as an integrator of actin ..
  70. Cabrita M, Gameiro C, Utkin A, Duarte B, Caçador I, Cartaxana P. Photosynthetic pigment laser-induced fluorescence indicators for the detection of changes associated with trace element stress in the diatom model species Phaeodactylum tricornutum. Environ Monit Assess. 2016;188:285 pubmed publisher
    ..rate, trace element content, chlorophyll a (Chl a) and carotenoid concentrations, and laser-induced fluorescence (LIF) spectra of Phaeodactylum tricornutum exposed to Co, Ni, Cu, Zn, Cd, Hg, Pb, and a mixture of all elements combined ..
  71. Pereira J, Pereira M, Rangel S, Saraiva M, Santos L, Cardoso J, et al. FADING EFFECT OF LiF:Mg,Ti AND LiF:Mg,Cu,P Ext-Rad AND WHOLE-BODY DETECTORS. Radiat Prot Dosimetry. 2016;170:177-80 pubmed publisher
    ..aim of this work was to compare the thermal stability of dosemeters of the Ext-Rad and whole-body card types with LiF:Mg,Ti and LiF:Mg,Cu,P detectors stored at different temperatures and periods...
  72. Chen Y, Kao S, Tai E, Wee H, Khoo E, Ning Y, et al. Utilizing distributional analytics and electronic records to assess timeliness of inpatient blood glucose monitoring in non-critical care wards. BMC Med Res Methodol. 2016;16:40 pubmed publisher
    ..The 1S-KS test was coupled with visualization via the cumulative distribution function (cdf) plot and a two-sample Kolmogorov-Smirnov (2S-KS) test, enabling comparison of the BG timing distributions between ..
  73. Sultana M, Bagul P, Katare P, Anwar Mohammed S, Padiya R, Banerjee S. Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes. Life Sci. 2016;164:42-51 pubmed publisher
    ..Rats with developed hyperglycemia after STZ injection were divided into two groups; diabetic (Dia) and diabetic+garlic (Dia+Garl). Garlic was administered at a dose of 250mg/kg/day, orally for four weeks...
  74. Luo Y, Mok T, Lin X, Zhang W, Cui Y, Guo J, et al. SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma. Sci Rep. 2017;7:41191 pubmed publisher
    ..The data-independent mode (DIA) based sequential window acquisition of all theoretical fragment-ion spectra (SWATH) mass spectrometry (MS) has ..
  75. Schultz R, Krug M, Precht M, Wohl S, Witte O, Schmeer C. Frataxin overexpression in Müller cells protects retinal ganglion cells in a mouse model of ischemia/reperfusion injury in vivo. Sci Rep. 2018;8:4846 pubmed publisher
    ..with increased expression of the antioxidant enzymes Gpx1 and Sod1 as well as the growth factors Cntf and Lif. Additionally, microglial activation was decreased in these mice...
  76. Aghajanova L, Skottman H, Strömberg A, Inzunza J, Lahesmaa R, Hovatta O. Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells. Fertil Steril. 2006;86:1193-209 pubmed
    ..the early spontaneous differentiation of human embryonic stem cells (hESCs), with particular emphasis on leukemia inhibitory factor (LIF)-induced pathways and the ultrastructural surface morphology of the undifferentiated and ..
  77. Mo W, Zhu S, Li Y, Kilper D. Dual-wavelength source based optical circuit switching and wavelength reconfiguration in multi-hop ROADM systems. Opt Express. 2017;25:27736-27749 pubmed publisher
    ..2 dB using dual-wavelength sources. A cumulative distribution function (CDF) of channel power excursions is generated from measurements of over 100 random channel loadings for four different ..
  78. Lowe D, Nunes W, Bombara M, McCabe S, Ranges G, Henzel W, et al. Genomic cloning and heterologous expression of human differentiation-stimulating factor. DNA. 1989;8:351-9 pubmed
    ..purified from mouse Ehrlich ascites cells was sequenced partially and found to be almost identical to leukemia inhibitory factor (LIF) from mouse Krebs II ascites cells...
  79. Evans J, Catalano R, Brown P, Sherwin R, Critchley H, Fazleabas A, et al. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB J. 2009;23:2165-75 pubmed publisher
    ..PROK1 induces expression of leukemia inhibitory factor (LIF) in endometrial epithelial cells and first trimester decidua via a Gq-Ca(2+)-cSrc-mitogen-activated ..
  80. Novotny Z, Krizan J, Sima R, Sima P, Uher P, Zech N, et al. Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. Folia Biol (Praha). 2009;55:92-7 pubmed
    The frequency of functionally relevant mutations of the leukaemia inhibitory factor (LIF) gene in infertile women is significantly enhanced in comparison with fertile controls...
  81. Barnes J, Lim J, Godard A, Blanchard F, Wells L, Steet R. Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms. J Biol Chem. 2011;286:24855-64 pubmed publisher
    ..In this study, we investigated the mannose phosphorylation status of leukemia inhibitory factor (LIF), a previously identified high affinity ligand for the cation-independent mannose 6-phosphate ..
  82. Kosfeld A, Brand F, Weiss A, Kreuzer M, Goerk M, Martens H, et al. Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations. Hum Mol Genet. 2017;26:1716-1731 pubmed publisher
    ..and trio-based de novo analysis, we identified a novel heterozygous de novo frameshift variant in the leukemia inhibitory factor receptor (LIFR) gene causing instability of the mRNA in a patient presenting with bilateral CAKUT and ..
  83. Margioula Siarkou C, Prapas Y, Petousis S, Milias S, Ravanos K, Dagklis T, et al. LIF endometrial expression is impaired in women with unexplained infertility while LIF-R expression in all infertility sub-groups. Cytokine. 2017;96:166-172 pubmed publisher
    ..Endometrial biopsy was performed on 7th-8th postovulatory menstrual day. Leukemia Inhibitory Factor (LIF) and LIF-Receptor (LIF-R) expression in epithelial and stromal cells were assessed with ..
  84. Cheng X, Liu J, Shan H, Sun L, Huang C, Yan Q, et al. Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro. Reprod Biol Endocrinol. 2017;15:42 pubmed publisher
    ..qRT-PCR and western blotting were performed to inspect LIF (leukemia inhibitory factor) expression after enhancement or inhibition of ATF3, and a luciferase reporter assay and ChIP-PCR were ..
  85. Vidybida A, Shchur O. Information reduction in a reverberatory neuronal network through convergence to complex oscillatory firing patterns. Biosystems. 2017;161:24-30 pubmed publisher
    ..The net, which is composed of 9 leaky integrate-and-fire (LIF) neurons arranged in a square lattice, is fully connected with interneuronal communication delay proportional to ..
  86. Hao S, Hou S, Hao Z, Cui G. A new three-dimensional bis(benzimidazole)-based cadmium(II) coordination polymer. Spectrochim Acta A Mol Biomol Spectrosc. 2018;189:613-620 pubmed publisher
    ..Single-crystal X-ray diffraction reveals CP 1 is a 3D 3-fold interpenetrated dia network with large well-defined pores...
  87. Bilski P, Marczewska B, Gieszczyk W, Klosowski M, Nowak T, Naruszewicz M. LITHIUM FLUORIDE CRYSTALS AS FLUORESCENT NUCLEAR TRACK DETECTORS. Radiat Prot Dosimetry. 2017;:1-4 pubmed publisher
    Radiophotoluminescence signal of LiF crystals was found to be sufficiently strong to visualize tracks of a single charged particle...
  88. Han H, Cui R, Lu G, Wu Z, Zheng Y, Zhou L, et al. Efficient orange-red electroluminescence of iridium complexes with 1-(2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline and 4-(2,6-bis(trifluoromethyl)pyridin-4-yl)quinazoline ligands. Dalton Trans. 2017;46:14916-14925 pubmed publisher
    ..2,6-bis(3-(carbazol-9-yl)phenyl)pyridine, 10 nm)/TmPyPB (1,3,5-tri(m-pyrid-3-yl-phenyl)benzene, 50 nm)/LiF (1 nm)/Al (100 nm) displays good electroluminescence performances with a maximum luminance of 96 609 cd m<..
  89. Edwards D, Moroz K, Zhang H, Mulholland D, Abdel Mageed A, Mondal D. PRL?3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients. Int J Oncol. 2017;: pubmed publisher
    ..Digital image analysis (DIA) revealed that PRL?3 expression was significantly higher in the malignant cores, as compared to the non?malignant ..
  90. Neuhuber W, Kressel M, Stark A, Berthoud H. Vagal efferent and afferent innervation of the rat esophagus as demonstrated by anterograde DiI and DiA tracing: focus on myenteric ganglia. J Auton Nerv Syst. 1998;70:92-102 pubmed
    Anterograde tracing with the carbocyanine tracer DiI and the aminostyrol derivative DiA was used to selectively label fibers from the nucleus ambiguus, dorsal motor nucleus and nodose ganglion, respectively, terminating in the rat ..
  91. Tanaka M, Hara T, Copeland N, Gilbert D, Jenkins N, Miyajima A. Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 1999;93:804-15 pubmed
    ..Of these family members, leukemia inhibitory factor (LIF) is most closely related to OSM, and various overlapping biologic activities have been described ..
  92. Boulanger M, Bankovich A, Kortemme T, Baker D, Garcia K. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell. 2003;12:577-89 pubmed
    ..We have determined the crystal structure of human leukemia inhibitory factor (LIF) bound to the cytokine binding region (CHR) of gp130 at 2.5 A resolution...