LGN

Summary

Gene Symbol: LGN
Description: G protein signaling modulator 2
Alias: CMCS, DFNB82, LGN, PINS, G-protein-signaling modulator 2, G-protein signalling modulator 2 (AGS3-like, C. elegans), mosaic protein LGN
Species: human
Products:     LGN

Top Publications

  1. Du Q, Taylor L, Compton D, Macara I. LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation. Curr Biol. 2002;12:1928-33 pubmed
    LGN is closely related to a Drosophila protein, Partner of inscuteable (Pins), which is required for polarity establishment and asymmetric cell divisions during embryonic development...
  2. Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, et al. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G?i/LGN/NuMA pathways. Mol Cell. 2011;43:418-31 pubmed publisher
    ..Evidence from invertebrates demonstrates that the Par3/Par6/aPKC and NuMA/LGN/G?i complexes, which are thought to be physically linked by the adaptor protein mInscuteable (mInsc), play ..
  3. Hao Y, Du Q, Chen X, Zheng Z, Balsbaugh J, Maitra S, et al. Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol. 2010;20:1809-18 pubmed publisher
    ..Confinement of the mammalian Pins protein to the lateral cortex is essential for this process...
  4. Woodard G, Huang N, Cho H, Miki T, Tall G, Kehrl J. Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol. 2010;30:3519-30 pubmed publisher
    ..Each treatment impaired the localization of LGN (GSPM2), NuMA (microtubule binding nuclear mitotic apparatus protein), and dynein at the metaphase cell cortex and ..
  5. Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, et al. Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem. 2005;280:6761-5 pubmed
    ..Par-6 complex. We showed here that Lgl2, a mammalian homolog of l(2)gl, directly bound to LGN, a mammalian homolog of Partner of inscuteable in HEK293 cells...
  6. Kiyomitsu T, Cheeseman I. Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat Cell Biol. 2012;14:311-7 pubmed publisher
    ..by controlling the interaction between dynein-dynactin and its upstream cortical targeting factors NuMA and LGN. Second, a chromosome-derived RanGTP gradient restricts the localization of NuMA-LGN to the lateral cell cortex to ..
  7. Zheng Z, Wan Q, Liu J, Zhu H, Chu X, Du Q. Evidence for dynein and astral microtubule-mediated cortical release and transport of G?i/LGN/NuMA complex in mitotic cells. Mol Biol Cell. 2013;24:901-13 pubmed publisher
    ..Here we show that mammalian homologue of Drosophila Pins (Partner of Inscuteable) (LGN), a G?i-binding protein that is critical for spindle positioning in different systems,..
  8. Du Q, Stukenberg P, Macara I. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol. 2001;3:1069-75 pubmed
    ..neuroblasts, this involves the interaction of the proteins Inscuteable (Insc) and Partner of inscuteable (Pins)...
  9. Du Q, Macara I. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell. 2004;119:503-16 pubmed
    ..In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit...

More Information

Publications126 found, 100 shown here

  1. Mapelli M, Gonzalez C. On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. Open Biol. 2012;2:120102 pubmed publisher
    ..polarity includes the molecular machinery pulling on astral microtubules, which is assembled on conserved NuMA:LGN:G?i complexes, the polarity proteins Par3:Par6:aPKC and an adaptor molecule known as Inscuteable (Insc)...
  2. Kaushik R, Yu F, Chia W, Yang X, Bahri S. Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression. Mol Biol Cell. 2003;14:3144-55 pubmed
    Mammalian LGN/AGS3 proteins and their Drosophila Pins orthologue are cytoplasmic regulators of G-protein signaling...
  3. Kotak S, Busso C, G nczy P. Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol. 2012;199:97-110 pubmed publisher
    ..Dynein and an evolutionarily conserved ternary complex (nuclear mitotic apparatus protein [NuMA]-LGN-G? in human cells and LIN-5-GPR-1/2-G? in Caenorhabditis elegans) are required for correct spindle positioning, but ..
  4. Long H, Yin H, Wang L, Gershwin M, Lu Q. The critical role of epigenetics in systemic lupus erythematosus and autoimmunity. J Autoimmun. 2016;74:118-138 pubmed publisher
    ..Importantly we emphasize that the stochastic processes that lead to DNA modification may be the lynch pins that drive the initial break in tolerance.
  5. Saare M, Lulla S, Tõnissoo T, Meier R, Kask K, Ruisu K, et al. Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS ONE. 2015;10:e0129131 pubmed publisher
    ..In addition, we demonstrate that RIC8 co-localizes with its interaction partners Gαi1/2:GDP and LGN in meiotic/mitotic spindle, cell cortex and polar bodies of maturing oocytes and zygotes...
  6. Wang Y, Fang X, Wang C, Ding C, Lin H, Liu A, et al. Exogenous PTHrP Repairs the Damaged Fracture Healing of PTHrP+/- Mice and Accelerates Fracture Healing of Wild Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..in bone fracture healing, closed mid-diaphyseal femur fractures were created and stabilized with intramedullary pins in eight-week-old wild-type (WT) PTHrP+/+ and PTHrP+/- mice...
  7. Fokou M, Moifo B, Fongang E, Teyang A, Muna W. Characteristics of patients and patterns of chronic venous disease of the lower limbs in a referral hospital in Cameroon. J Vasc Surg Venous Lymphat Disord. 2018;6:90-95 pubmed publisher
    ..48%); sensation of swelling, 236 (64.48%); pain, 194 (53%); sensation of "pins and needles," 87 (23.77%); night cramps, 89 (24.39%); and itching, 66 (18.03%). Men had more symptoms (P = .027)...
  8. Green M, Hou B. Cellular Changes of Stem Cells in 3-Dimensional Culture. J Oral Maxillofac Surg. 2017;75:2477.e1-2477.e9 pubmed publisher
    ..The variables tested were a no-force model (control) and a force model. The force model required two 0.1-mm suture pins put through one 0.25-cm length of cell-gel matrix...
  9. Myrissa A, Braeuer S, Martinelli E, Willumeit Römer R, Goessler W, Weinberg A. Gadolinium accumulation in organs of Sprague-Dawley® rats after implantation of a biodegradable magnesium-gadolinium alloy. Acta Biomater. 2017;48:521-529 pubmed publisher
    ..In this study Mg10Gd pins were implanted into Sprague-Dawley® rats...
  10. Belzile E, Hébert M, Janelle N, Lechasseur B, Dessery Y, Ayeni O, et al. Capsular plication in the non-deformity hip: impact on post-operative joint stability. J Exp Orthop. 2019;6:3 pubmed publisher
    ..They were fixed to the operating room table using a custom-made apparatus. Three Steinman pins were inserted, the first into ASIS, a parallel pin into the distal femur proximal to inter-epicondylar axis and the ..
  11. Mattei T, Rehman A, Issawi A, Fassett D. Surgical challenges in the management of cervical kyphotic deformity in patients with severe osteoporosis: an illustrative case of a patient with Hajdu-Cheney syndrome. Eur Spine J. 2015;24:2746-53 pubmed publisher
    ..recommendations for cervical deformity surgery in patients with severe osteoporosis, such as avoidance of Caspar pins for interbody distraction, use of intra-operative fluoroscopy for achievement of bicortical purchase of anterior ..
  12. Gelse K, Biggemann J, Stumpf M, Halmheu M, Grüneboom A, Scholtysek C, et al. Modular lattice constructs for biological joint resurfacing. Tissue Eng Part A. 2019;: pubmed publisher
    ..tricalcium phosphate, biphasic calcium phosphate, alumina and bioactive glass) including anchoring pins were fabricated by transfer injection molding technique...
  13. Yeung D, Jia X, Miller C, Barker S. Interventions for treating ankle fractures in children. Cochrane Database Syst Rev. 2016;4:CD010836 pubmed publisher
    ..Treatment generally involves splints and casts for minor fractures and surgical fixation with screws, plates and pins followed by immobilisation for more serious fractures...
  14. Bosveld F, Markova O, Guirao B, Martin C, Wang Z, Pierre A, et al. Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis. Nature. 2016;530:495-8 pubmed publisher
    ..microtubules and orienting cell division via the Dynein-associated protein Mud independently of the classical Pins/Gαi pathway...
  15. Song X, Teng J, Wang A, Li X, Wang J, Liu Y. Positive correlation between serum IGF-1 and HDL-C in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2016;118:44-9 pubmed publisher
    ..05). Moreover, HDL-C, postprandial blood glucose, FINS, postprandial plasma insulin (PINS), hip circumference ratio, glycated hemoglobin A1c were significantly lower in G3 than in G2 (P<0.05)...
  16. Baykal D, Siskey R, Underwood R, Briscoe A, Kurtz S. The Biotribology of PEEK-on-HXLPE Bearings Is Comparable to Traditional Bearings on a Multidirectional Pin-on-disk Tester. Clin Orthop Relat Res. 2016;474:2384-2393 pubmed
    ..3 ± 0.1 mm3/MC for PEEK pins [95% CI, 0.2-0.3 mm3/MC] [representing full cross-shear condition] and 0.0 ± 1...
  17. Forouharmajd F, Yadegari M, Ahmadvand M, Forouharmajd F, Pourabdian S. Hand-arm Vibration Effects on Performance, Tactile Acuity, and Temperature of Hand. J Med Signals Sens. 2017;7:252-260 pubmed
    ..The common signs and symptoms of hand-arm vibration (HAV) in the fingers and hands may appear as pins and needles feeling, tingling, numbness, and also the loss of finger sensation and dexterity...
  18. Hioki A, Miyamoto K, Inoue T, Hosoe H, Shinoda J, Iwama T, et al. Successful antibiotic treatment for subdural empyema and seizure due to methicillin-resistant Staphylococcus aureus as a complication of halo orthosis usage: a case report. Eur J Orthop Surg Traumatol. 2012;22 Suppl 1:25-8 pubmed publisher
    ..empyema due to methicillin-resistant Staphylococcus aureus (MRSA) caused by intracranial penetration of halo pins. A 38-year-old woman with a 4-year history of rheumatoid arthritis experienced severe myelopathy due to atlanto-..
  19. Cook N, Hess J, Foy M, Bennett T, Brotzman R. Management characteristics, lameness, and body injuries of dairy cattle housed in high-performance dairy herds in Wisconsin. J Dairy Sci. 2016;99:5879-5891 pubmed publisher
    ..0±4.1%. Back injuries (proportion of cows with missing or abraded spinous processes, hooks, or pins) followed a similar trend with a low mean prevalence of 3.6±3.4%...
  20. Guan W, Yang G. Significance of change of retinol binding protein 4 level of plasma of patients with coronary heart disease complicated with hyperlipidemia. Eur Rev Med Pharmacol Sci. 2016;20:4136-4140 pubmed
    ..05). The level of LDL-C in CHD group was higher than that in control group (p<0.05); FIns, 2h PIns, HOMA-IR and RBP4 of CHD-H group were significantly higher than those of the control group and CHD group (p<0...
  21. Pugliese R, Slagle E, Oettinger G, Neuburger K, Ambrose T. Subacute combined degeneration of the spinal cord in a patient abusing nitrous oxide and self-medicating with cyanocobalamin. Am J Health Syst Pharm. 2015;72:952-7 pubmed publisher
    ..The patient also complained of worsening lower-extremity weakness for 10 days and a "pins and needles" sensation in the lower extremities for approximately 1 year...
  22. Tanaka R, Nagahara H, Maeda K, Ohtani H, Shibutani M, Tamura T, et al. A case of bowel perforation due to traumatic hernia at a pelvic fracture site: a case report and review of the literature. BMC Surg. 2017;17:81 pubmed publisher
    ..performed segmental jejunum resection and constructed jejunostomy, and the iliac bone fracture was fixed with four pins. In the postoperative course, she received antibiotics and vasopressors for septic shock...
  23. Kelechi T, Dooley M, Mueller M, Madisetti M, Prentice M. Symptoms Associated With Chronic Venous Disease in Response to a Cooling Treatment Compared to Placebo: A Randomized Clinical Trial. J Wound Ostomy Continence Nurs. 2018;45:301-309 pubmed publisher
    ..legs, swelling, night cramps, heating or burning sensation, restless legs, throbbing, itching, tingling sensation (pins and needles), pain, and irritability...
  24. Greyvensteyn G, Madaree A. A low-cost method of craniofacial distraction osteogenesis. J Plast Reconstr Aesthet Surg. 2016;69:409-16 pubmed publisher
    ..The apparatus used included Steinmann pins, stainless steel wires, attachment bolts, orthopaedic pulleys, string and intravenous bags for weights...
  25. Inzana J, Schwarz E, Kates S, Awad H. A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone. 2015;72:128-36 pubmed publisher
    ..in current mouse models of implant-associated bone infection have been limited to intramedullary or trans-cortical pins, which are not amenable to treatments involving extensive debridement of a full-thickness bone loss and placement ..
  26. Zhang Y, Qu H, Zhou Y, Wang Y, Zhang D, Yang X, et al. The involvement of norepinephrine in pain modulation in the nucleus accumbens of morphine-dependent rats. Neurosci Lett. 2015;585:6-11 pubmed publisher
    ..we examined the role of NE on the evoked discharges of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the nucleus accumbens (NAc) of rats, following the development of morphine dependence...
  27. Rahim M, Weizbauer A, Evertz F, Hoffmann A, Rohde M, Glasmacher B, et al. Differential magnesium implant corrosion coat formation and contribution to bone bonding. J Biomed Mater Res A. 2017;105:697-709 pubmed publisher
    ..When magnesium pins were inserted into avital bones, corrosion lead to increases in the pull out force, suggesting that the expanding ..
  28. Shahin H, Walsh T, Rayyan A, Lee M, Higgins J, DICKEL D, et al. Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. Eur J Hum Genet. 2010;18:407-13 pubmed publisher
    ..3 (DFNB82), 9p23-p21.2/p13.3-q21.13 (DFNB83), 12q14.3-q21.2 (DFNB84; two families), 14q23.1-q31.1, and 17p12-q11.2 (DFNB85).
  29. Rezende M, Cunha P, Damante C, Santana A, Greghi S, Zangrando M. Cyanoacrylate Adhesive as an Alternative Tool for Membrane Fixation in Guided Tissue Regeneration. J Contemp Dent Pract. 2015;16:512-8 pubmed
    ..However, some membranes are very difficult to be kept in position by sutures and its fixation by mini screws or pins may be time consuming and expensive...
  30. Okabayashi H, Kanbe H, O Connor C. The role of an L-leucine residue on the conformations of glycyl-L-leucine oligomers and its N- or C-terminal dependence: infrared absorption and Raman scattering studies. Eur Biophys J. 2016;45:23-34 pubmed publisher
    ..However, for L-leucyl-glycine oligomers (LGn; n = 3, 4, 5) in the solid state, LG3 and LG4 have already been confirmed to take a reverse-turn structure (LG3-..
  31. Tamada M, Zallen J. Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling. Dev Cell. 2015;35:151-61 pubmed publisher
    ..Spitz orients cell divisions through a Pins/LGN-dependent spindle-positioning mechanism and controls cell shape and alignment through a transcriptional pathway ..
  32. Bae D, Ko Y, Kim S, Baek J, Song S. Computer-assisted navigation decreases the change in the tibial posterior slope angle after closed-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2016;24:3433-3440 pubmed
    ..2° ± 5.3° in the conventional group. Computer-assisted CWHTO using four guide pins could avoid inadvertent change in the PSA...
  33. Sun G, Yin C, Liu Z, Wang L, Mu W. Three-dimensionally-navigated cross-cannulated screw fixation for traumatic pubic symphysis diastasis: an anatomical study. Acta Orthop Traumatol Turc. 2016;50:214-21 pubmed publisher
    ..According to the above data, cross-cannulated screws 6.5 mm in diameter were implanted by the guide pins. Based on detailed local dissection, the entry-exit points of double screws were exposed in the pelvis...
  34. Wölwer C, Godde N, Pase L, Elsum I, Lim K, Sacirbegovic F, et al. The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation. PLoS ONE. 2017;12:e0170295 pubmed publisher
    ..Here we investigated gene expression of members of the Par, Scribble and Pins/Gpsm2 asymmetric cell division complexes in erythroid cells, and functionally tested their role in erythroid ..
  35. Kremers J, Silveira L, Kilavik B. Influence of contrast on the responses of marmoset lateral geniculate cells to drifting gratings. J Neurophysiol. 2001;85:235-46 pubmed
    The responses of lateral geniculate nucleus (LGN) cells in the common marmoset (Callithrix jacchus) to drifting luminance or cone isolating gratings of different spatial frequencies and contrasts were measured...
  36. Corrigan A, Shrestha R, Zulkipli I, Hiroi N, Liu Y, Tamura N, et al. Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle. 2013;12:2643-55 pubmed publisher
    ..By quantifying spindle movements in cells depleted of LGN, we show that the first regime of rotational movements requires LGN that recruits cortical dynein...
  37. Pozsgay J, Szarka E, Huber K, Babos F, Magyar A, Hudecz F, et al. Synthetic Peptide-Based ELISA and ELISpot Assay for Identifying Autoantibody Epitopes. Methods Mol Biol. 2016;1352:223-33 pubmed publisher
    ..A large set of peptides synthesized on the crown of pins can be tested by Multipin ELISA for fast screening...
  38. Bumči I, Vlahović T, Jurić F, Žganjer M, Miličić G, Wolf H, et al. Evaluation of stability of osteosynthesis with K-wires on an artificial model of tibial malleolus fracture. Injury. 2015;46 Suppl 6:S5-13 pubmed publisher
    ..Considering the rules of mechanics, it is assumed that the two temporary pins with the additional third pin placed parallel to the physis create a strong triangle and thus provide strong ..
  39. Xi W, Gong X, Yang Q, Yu H, Liou Y. Pin1At regulates PIN1 polar localization and root gravitropism. Nat Commun. 2016;7:10430 pubmed publisher
    ..PINOID (PID) and PROTEIN PHOSPHATASE 2A (PP2A) act antagonistically on reversible phosphorylation of PINs. This regulates polar PIN distribution and auxin transport...
  40. Dong H, Mukinay T, Li M, Hood R, Soo S, Cockshott S, et al. Improving tribological and anti-bacterial properties of titanium external fixation pins through surface ceramic conversion. J Mater Sci Mater Med. 2017;28:5 pubmed
    ..surface engineering technology has been applied for the first time to self-drilling Ti6Al4V external fixation pins to improve their performance in terms of biomechanical, bio-tribological and antibacterial properties...
  41. Stigliani A, Jeska B, Grill Spector K. Encoding model of temporal processing in human visual cortex. Proc Natl Acad Sci U S A. 2017;114:E11047-E11056 pubmed publisher
    ..is relayed to V1 through segregated transient and sustained channels in the retina and lateral geniculate nucleus (LGN)...
  42. Maier D, Izadpanah K, Ogon P, Mützel M, Bayer J, Südkamp N, et al. Open fixation of acute anterior glenoid rim fractures with bioresorbable pins: analysis of clinical and radiological outcome. Arch Orthop Trauma Surg. 2015;135:953-61 pubmed publisher
    ..results following open fixation of acute-traumatic, displaced anterior glenoid rim fractures with bioresorbable pins. This retrospective study included 17 patients with glenoid defect sizes ≥20 %, as directly measured in ..
  43. Adrian M, Wachtlin D, Kronfeld K, Sommerfeldt D, Wessel L. A comparison of intervention and conservative treatment for angulated fractures of the distal forearm in children (AFIC): study protocol for a randomized controlled trial. Trials. 2015;16:437 pubmed publisher
    ..Should remodeling appear to be a safe alternative, manipulation under general anesthesia, K-wire pinning and removal of pins could be avoided, thus sparing significant costs. DRKS00004874 , 30 October 2013.
  44. Lopes O, de Freitas Spinelli L, Leite L, Buzzeto B, Saggin P, Kuhn A. Femoral tunnel enlargement after anterior cruciate ligament reconstruction using RigidFix compared with extracortical fixation. Knee Surg Sports Traumatol Arthrosc. 2017;25:1591-1597 pubmed publisher
    ..ligament (ACL) reconstruction surgery using hamstring autograft tendons fixed by bioabsorbable femoral trans-tunnel pins with that in patients in which the graft was fixed with extracortical fixation...
  45. Di Dona F, Della Valle G, Lamagna B, Balestriere C, Murino C, Santangelo B, et al. Percutaneous transilial pinning for treatment of seventh lumbar vertebral body fracture. A retrospective analysis of 17 cases. Vet Comp Orthop Traumatol. 2016;29:164-9 pubmed publisher
    ..The use of two percutaneous transilial pins can be considered as treatment for the management of seventh lumbar fracture-luxation in dogs...
  46. Klein C, Evrard H, Shapcott K, Haverkamp S, Logothetis N, Schmid M. Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex. Neuron. 2016;90:143-51 pubmed publisher
    ..microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1)...
  47. Phanindranath R, Sudhakar D, Sharma A, Thangaraj K, Sharma Y. Optimization of purification method and characterization of recombinant human Centrin-1. Protein Expr Purif. 2016;124:48-54 pubmed publisher
    ..of centrins for biophysical studies involves either multiple steps or yields protein with an affinity tag, which pins additional tag-cleavage step...
  48. Constantino J, Delgado Rastrollo M, Pacha Olivenza M, Pérez Giraldo C, Quiles M, González Martín M, et al. In vivo bactericidal efficacy of farnesol on Ti6Al4V implants. Rev Esp Cir Ortop Traumatol. 2016;60:260-6 pubmed publisher
    ..001) on applying the Student t test for related samples. The median reduction obtained in farnesol pins relative to the control was 74%...
  49. Ercin E, Bilgili M, Baca E, Basaran S, Bayrak A, Kural C, et al. Medial mini-open versus percutaneous pin fixation for type III supracondylar fractures in children. Ulus Travma Acil Cerrahi Derg. 2016;22:350-4 pubmed publisher
    ..In Group A (41 patients), medial pin was inserted with mini-open incision with 2 lateral pins inserted percutaneously. In Group B (63 patients), all pins were inserted percutaneously...
  50. Strbac G, Schnappauf A, Giannis K, Moritz A, Ulm C. Guided Modern Endodontic Surgery: A Novel Approach for Guided Osteotomy and Root Resection. J Endod. 2017;43:496-501 pubmed publisher
    ..With the aid of virtually positioned surgical pins and piezoelectric instruments, the osteotomy size, the apical resection level, and the bevel angle were defined ..
  51. Lai A, Christou C, BAILEY C, Tan C, Culvenor J, Wang T, et al. Biomechanical comparison of pin and nitinol bone staple fixation to pin and tension band wire fixation for the stabilization of canine olecranon osteotomies. Vet Comp Orthop Traumatol. 2017;30:324-330 pubmed publisher
    To compare the initial biomechanical properties of olecranon osteotomies stabilized with intramedullary pins and a Nitinol bone staple to osteotomies stabilized with pin and tension band wire fixation...
  52. Xie J, Zhou Z, Ma J, Xiang C, Nie Q, Zhang W. Graphics processing unit-based alignment of protein interaction networks. IET Syst Biol. 2015;9:120-7 pubmed publisher
    ..subgraph isomorphism problem complicates and increases the time required to align protein interaction networks (PINs)...
  53. Kammen A, Law M, Tjan B, Toga A, Shi Y. Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis. Neuroimage. 2016;125:767-779 pubmed publisher
    ..projection, which consists of the optic nerves, optic chiasm, optic tracts, the lateral geniculate nuclei (LGN) and the optic radiations...
  54. Carminati M, Gallini S, Pirovano L, Alfieri A, Bisi S, Mapelli M. Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation. Nat Struct Mol Biol. 2016;23:155-63 pubmed publisher
    ..cues trigger the recruitment of NuMA-dynein-based motors, which pull on astral microtubules via the protein LGN. We demonstrate that the junctional protein Afadin is required for spindle orientation and correct epithelial ..
  55. Ronk M, Lee H, Fujimori K, Yeh P, Nashed Samuel Y. Characterization of Protein Aggregating Tungstates: Electrospray Mass Spectrometry Analysis of Extracts from Prefilled Syringes and from Tungsten Pins Used in the Manufacture of Syringes. PDA J Pharm Sci Technol. 2016;70:51-61 pubmed publisher
    ..leaching from a PFS is known to induce protein particle formation, and the source was traced to the tungsten pins used in the manufacturing process of the syringe barrels...
  56. Tripathi S, Moutari S, Dehmer M, Emmert Streib F. Comparison of module detection algorithms in protein networks and investigation of the biological meaning of predicted modules. BMC Bioinformatics. 2016;17:129 pubmed publisher
    ..module prediction methods for simulated benchmark networks as well as 10 biological protein interaction networks (PINs)...
  57. Chruscinski A, Huang F, Ulndreaj A, Chua C, Fehlings M, Rao V, et al. Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies. J Vis Exp. 2016;: pubmed publisher
    ..Here we describe methods to generate custom antigen microarrays. Our current arrays are printed with 9 solid pins and can include up to 162 antigens spotted in duplicate...
  58. Saadaoui M, Konno D, Loulier K, Goïame R, Jadhav V, Mapelli M, et al. Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3. EMBO Rep. 2017;18:1509-1520 pubmed publisher
    In many cell types, mitotic spindle orientation relies on the canonical "LGN complex" composed of Pins/LGN, Mud/NuMA, and Gαi subunits...
  59. Funabashi M, Nougarou F, Descarreaux M, Prasad N, Kawchuk G. Influence of Spinal Manipulative Therapy Force Magnitude and Application Site on Spinal Tissue Loading: A Biomechanical Robotic Serial Dissection Study in Porcine Motion Segments. J Manipulative Physiol Ther. 2017;40:387-396 pubmed publisher
    ..Vertebral kinematics were tracked optically using indwelling bone pins, the motion segment removed and mounted in a parallel robot equipped with a 6-axis load cell...
  60. Pishas K, Adwal A, Neuhaus S, Clayer M, Farshid G, Staudacher A, et al. XI-006 induces potent p53-independent apoptosis in Ewing sarcoma. Sci Rep. 2015;5:11465 pubmed publisher
    ..Finally, potent synergy between XI-006 and olaparib (PARP inhibitor) were observed due to the down-regulation of Mre11. Our findings suggest that XI-006 represents a novel therapeutic intervention for the treatment of Ewing sarcoma. ..
  61. Nomura T, Ohtaka Maruyama C, Yamashita W, Wakamatsu Y, Murakami Y, Calegari F, et al. The evolution of basal progenitors in the developing non-mammalian brain. Development. 2016;143:66-74 pubmed publisher
    ..Manipulation of LGN (Leu-Gly-Asn repeat-enriched protein) and Cdk4/cyclin D1, both essential regulators of neural progenitor dynamics, ..
  62. Kurashige T, Suzuki S. An Isolated Chronic Osteochondral Fracture of the Third Metatarsal Head Treated With Bioabsorbable Pins: A Case Report. Foot Ankle Spec. 2016;: pubmed
    ..We achieved a good result 12 months postoperatively by using open reduction and internal fixation with 2 bioabsorbable thread pins. Therapeutic, Level IV: Case study.
  63. Mitra A, Bajpai M. Impacted Sharp Oesophageal Foreign Bodies--A Novel Technique of Removal with the Paediatric Bronchoscope. J Trop Pediatr. 2016;62:161-4 pubmed publisher
    ..Safety pins, razor blades and needles are a few of the commonly ingested sharp objects in developing countries...
  64. Davis A, Manaqibwala M, Brown C, Steiner M. Height and Depth Guidelines for Anatomic Femoral Tunnels in Anterior Cruciate Ligament Reconstruction: A Cadaveric Study. Arthroscopy. 2016;32:1098-105 pubmed publisher
    ..of the guidelines arthroscopically with or without the assistance of a 7-mm offset aimer placed all guide pins for tunnels within the femoral ACL footprint, with 90% within 4 mm of the ACL center...
  65. Poltoratski S, Ling S, McCormack D, Tong F. Characterizing the effects of feature salience and top-down attention in the early visual system. J Neurophysiol. 2017;118:564-573 pubmed publisher
    ..multiple sites along the early visual pathway, including visual areas V1-V4 and the lateral geniculate nucleus (LGN)...
  66. Hasse J, Briggs F. Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret. Proc Natl Acad Sci U S A. 2017;114:E6222-E6230 pubmed publisher
    The corticogeniculate (CG) pathway connects the visual cortex with the visual thalamus (LGN) in the feedback direction and enables the cortex to directly influence its own input...
  67. Gainotti G. Implications of recent findings for current cognitive models of familiar people recognition. Neuropsychologia. 2015;77:279-87 pubmed publisher
    ..data have shown that familiarity judgements are not generated at the level of the Person Identity Nodes (PINs), as suggested by influential cognitive models, but at the level of the modality-specific recognition units, with a ..
  68. Dewey E, Sanchez D, Johnston C. Warts phosphorylates mud to promote pins-mediated mitotic spindle orientation in Drosophila, independent of Yorkie. Curr Biol. 2015;25:2751-2762 pubmed publisher
    ..Here, we describe a role for the Hippo (Hpo) kinase complex in promoting Partner of Inscuteable (Pins)-mediated spindle orientation...
  69. Blakeslee J, Bandyopadhyay A, Lee O, Mravec J, Titapiwatanakun B, Sauer M, et al. Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis. Plant Cell. 2007;19:131-47 pubmed
    ..These results suggest that PINs and PGPs characterize coordinated, independent auxin transport mechanisms but also function interactively in a ..
  70. Yariz K, Walsh T, Akay H, Duman D, Akkaynak A, King M, et al. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Clin Genet. 2012;81:289-93 pubmed publisher
    ..family, GPSM2 was recently discovered to be the cause of autosomal recessive non-syndromic hearing loss DFNB82. Here, we report a second truncating mutation, GPSM2 p...
  71. Bhonker Y, Abu Rayyan A, Ushakov K, Amir Zilberstein L, Shivatzki S, Yizhar Barnea O, et al. The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome. 2016;27:29-46 pubmed publisher
    ..GPSM2/LGN, a mitotic spindle-orienting protein associated with deafness in humans, is a PCP effector involved in kinocilium ..
  72. Naramoto S. Polar transport in plants mediated by membrane transporters: focus on mechanisms of polar auxin transport. Curr Opin Plant Biol. 2017;40:8-14 pubmed publisher
    ..In this review, the regulatory mechanisms underlying polar localization of PINs, control of auxin efflux activity, and PIN abundance at PMs are considered...
  73. Moran C, Harper T, Joslyn S, Whittington J, Hague D, Mitchell M, et al. Computed tomographic study of safe implantation corridors in rabbit lumbar vertebrae. Vet Comp Orthop Traumatol. 2017;30:357-363 pubmed publisher
    ..03 mm (range: 1.60- 2.07). Post-placement imaging revealed that 35% of the pins demonstrated errors of placement, most commonly canal impingement...
  74. Dwivedi Y, Laurent M, Sarvepalli S, Schmid T, Wimmer M. Albumin Protein Cleavage Affects the Wear and Friction of Ultra-High Molecular Weight Polyethylene. Lubricants. 2017;5: pubmed publisher
    ..In pin-on-flat (POF) wear tests of polyethylene pins made of Ticona GUR® 1020/1050 against CoCrMo alloy discs, the cleaved albumin led to the lowest ..
  75. Mazade R, Alonso J. Thalamocortical processing in vision. Vis Neurosci. 2017;34:E007 pubmed publisher
    ..reaches the cerebral cortex through a major thalamocortical pathway that connects the lateral geniculate nucleus (LGN) of the thalamus with the primary visual area of the cortex (area V1). In humans, ?3...
  76. Eiber C, Pietersen A, Zeater N, Solomon S, Martin P. Chromatic summation and receptive field properties of blue-on and blue-off cells in marmoset lateral geniculate nucleus. Vision Res. 2018;151:41-52 pubmed publisher
    The "blue-on" and "blue-off" receptive fields in retina and dorsal lateral geniculate nucleus (LGN) of diurnal primates combine signals from short-wavelength sensitive (S) cone photoreceptors with signals from medium/long wavelength ..
  77. Troyer T, Krukowski A, Miller K. LGN input to simple cells and contrast-invariant orientation tuning: an analysis. J Neurophysiol. 2002;87:2741-52 pubmed
    We develop a new analysis of the lateral geniculate nucleus (LGN) input to a cortical simple cell, demonstrating that this input is the sum of two terms, a linear term and a nonlinear term...
  78. Lázaro Diéguez F, Cohen D, Fernandez D, Hodgson L, Van IJzendoorn S, Müsch A. Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes. J Cell Biol. 2013;203:251-64 pubmed publisher
    ..kinase Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes...
  79. Parumasivam T, Leung S, Tang P, Mauro C, Britton W, Chan H. The Delivery of High-Dose Dry Powder Antibiotics by a Low-Cost Generic Inhaler. AAPS J. 2017;19:191-202 pubmed publisher
    ..In some prototypes, four piercing pins of 0.6 mm each were replaced with a single centrally located 1...
  80. He X, Zhang Y, Yu J, Gan Y, Han N, Zhang M, et al. High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway. Tumour Biol. 2017;39:1010428317695971 pubmed publisher
  81. Wertheimer C, Eibl Lindner K, Compera D, Kueres A, Wolf A, Docheva D, et al. A cell culture technique for human epiretinal membranes to describe cell behavior and membrane contraction in vitro. Graefes Arch Clin Exp Ophthalmol. 2017;255:2147-2155 pubmed publisher
    ..Specimens were fixed on cell culture plastic using small entomological pins to apply horizontal stress to the tissue, and then transferred to standard cell culture conditions...
  82. Nguyen T, Tagett R, Diaz D, Draghici S. A novel approach for data integration and disease subtyping. Genome Res. 2017;: pubmed publisher
    ..a novel approach, called perturbation clustering for data integration and disease subtyping (PINS), which is able to address both challenges...
  83. Holler M, Raabe J, Wepf R, Shahmoradian S, Diaz A, Sarafimov B, et al. OMNY PIN-A versatile sample holder for tomographic measurements at room and cryogenic temperatures. Rev Sci Instrum. 2017;88:113701 pubmed publisher
    ..of high-pressure frozen biological samples, in the present case Chlamydomonas cells, the related sample pins and preparation steps...
  84. Cipriano A, Lin J, Lin A, Sallee A, Le B, Cortez Alcaraz M, et al. Degradation of Bioresorbable Mg-4Zn-1Sr Intramedullary Pins and Associated Biological Responses in Vitro and in Vivo. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..properties of as-drawn Mg-4Zn-1Sr (designated as ZSr41) and pure Mg (P-Mg) wires as bioresorbable intramedullary pins for bone repair...
  85. Mochizuki N, Cho G, Wen B, Insel P. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. Gene. 1996;181:39-43 pubmed
    ..The deduced protein contains 10 Leu-Gly-Asn repeats, and thus we named it LGN. Computer analysis indicates that LGN is a mosaic protein with seven repeated sequences of about 40 aa in length at ..
  86. Irvin M, Shrestha S, Chen Y, Wiener H, Haritunians T, Vaughan L, et al. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. Pharmacogenet Genomics. 2011;21:798-807 pubmed publisher
  87. Takayanagi H, Yuzawa S, Sumimoto H. Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN. Acta Crystallogr F Struct Biol Commun. 2015;71:175-83 pubmed publisher
    The adaptor protein LGN interacts via the N-terminal domain comprising eight tetratricopeptide-repeat (TPR) motifs with its partner proteins mInsc, NuMA, Frmpd1 and Frmpd4 in a mutually exclusive manner...
  88. Ehatisham Ul Haq M, Azam M, Loo J, Shuang K, Islam S, Naeem U, et al. Authentication of Smartphone Users Based on Activity Recognition and Mobile Sensing. Sensors (Basel). 2017;17: pubmed publisher
    ..approach for protecting this type of data on mobile devices is to authenticate users with mechanisms such as PINs, passwords, and fingerprint recognition...
  89. Durnev V, Soljakova M, Filipce V, Mijovska M, Stevanovska M. Hemodynamic and Bispectral Changes During Pin Insertion in Craniotomy - Effect of Locally Infiltrated Bupivacaine. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017;38:115-121 pubmed publisher
    Introduction Cranial pins insertion is a method for head stabilization and together with the scalp incision is one of the biggest noxious stimulus associated with arousal and rapid increase of the blood pressure leading to pathological ..
  90. Annunziata M, Nastri L, Cecoro G, Guida L. The Use of Poly-d,l-lactic Acid (PDLLA) Devices for Bone Augmentation Techniques: A Systematic Review. Molecules. 2017;22: pubmed publisher
    ..acid (PDLLA) has been proposed in dentistry for regenerative procedures in the form of membranes, screws, and pins. The aim of this review was to evaluate the efficacy of bone augmentation techniques using PDLLA devices...
  91. Olland A, Reeb J, Guinard S, Seitlinger J, Santelmo N, Kessler R, et al. Clamshell Closure With Absorbable Sternal Pins in Lung Transplant Recipients. Ann Thorac Surg. 2017;104:e207-e209 pubmed publisher
    ..We describe the use of new absorbable sternal pins to stabilize the sternal closure and to help avoid additional sternal complications.
  92. Ackland D, Griggs I, Hislop P, Wu W, Patel M, Richardson M. An intramedullary Echidna pin for fixation of comminuted clavicle fractures: a biomechanical study. J Orthop Surg Res. 2017;12:122 pubmed publisher
    ..mid-shaft clavicle fractures has traditionally been employed with satisfactory clinical outcomes; however, pins with smooth surfaces may protrude from the bone and are prone to migration, while some threaded pins are ..