LGI1

Summary

Gene Symbol: LGI1
Description: leucine rich glioma inactivated 1
Alias: ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine-rich glioma-inactivated protein 1, epitempin-1
Species: human
Products:     LGI1

Top Publications

  1. Chernova O, Somerville R, Cowell J. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene. 1998;17:2873-81 pubmed
    ..We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene-Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced ..
  2. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker Cummings C, Martinelli Boneschi F, et al. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet. 2002;30:335-41 pubmed
    ..we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with ..
  3. Chabrol E, Popescu C, Gourfinkel An I, Trouillard O, Depienne C, Senechal K, et al. Two novel epilepsy-linked mutations leading to a loss of function of LGI1. Arch Neurol. 2007;64:217-22 pubmed
    Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy...
  4. Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002;11:1757-62 pubmed
    ..epilepsy, and the LGI1 gene, which is mutated in autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  5. Kunapuli P, Kasyapa C, Hawthorn L, Cowell J. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. J Biol Chem. 2004;279:23151-7 pubmed
    ..Progressive loss of LGI1 expression has been associated with the development of high grade gliomas...
  6. Fukata Y, Adesnik H, Iwanaga T, Bredt D, Nicoll R, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science. 2006;313:1792-5 pubmed
    ..However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1...
  7. Staub E, Perez Tur J, Siebert R, Nobile C, Moschonas N, Deloukas P, et al. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci. 2002;27:441-4 pubmed
    Recent studies suggest that mutations in the LGI1/Epitempin gene cause autosomal dominant lateral temporal epilepsy. This gene encodes a protein of unknown function, which we postulate is secreted...
  8. Sirerol Piquer M, Ayerdi Izquierdo A, Morante Redolat J, Herranz Pérez V, Favell K, Barker P, et al. The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet. 2006;15:3436-45 pubmed
    ..b>ADLTE-related mutants of the long form are defective for secretion and are retained in the endoplasmic reticulum and ..
  9. Owuor K, Harel N, Englot D, Hisama F, Blumenfeld H, Strittmatter S. LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci. 2009;42:448-57 pubmed publisher
    ..ADAM11, nor some forms of ADAM22, contain PDZ-interacting sequences, suggesting PSD-95-independent mechanisms in ADPEAF. Because ADAMs modulate integrins, we examined LGI1 effect on neurite outgrowth...

More Information

Publications108 found, 100 shown here

  1. Ottman R, Risch N, Hauser W, Pedley T, Lee J, Barker Cummings C, et al. Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet. 1995;10:56-60 pubmed
    ..83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval. ..
  2. Morante Redolat J, Gorostidi Pagola A, Piquer Sirerol S, Saenz A, Poza J, Galán J, et al. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet. 2002;11:1119-28 pubmed
    ..Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder...
  3. Nobile C, Michelucci R, Andreazza S, Pasini E, Tosatto S, Striano P. LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy. Hum Mutat. 2009;30:530-6 pubmed publisher
    Autosomal dominant lateral temporal epilepsy (ADLTE) or autosomal dominant partial epilepsy with auditory features (ADPEAF) is an inherited epileptic syndrome with onset in childhood/adolescence and benign evolution...
  4. Kunapuli P, Chitta K, Cowell J. Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene. Oncogene. 2003;22:3985-91 pubmed
    The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line...
  5. Berkovic S, Izzillo P, McMahon J, Harkin L, McIntosh A, Phillips H, et al. LGI1 mutations in temporal lobe epilepsies. Neurology. 2004;62:1115-9 pubmed
    ..have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  6. Gu W, Brodtkorb E, Steinlein O. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. Ann Neurol. 2002;52:364-7 pubmed
    ..lateral temporal lobe epilepsy previously has been linked to chromosome 10q22-q24, and recently mutations in the LGI1 gene (Leucine-rich gene, Glioma Inactivated) have been found in some autosomal dominant lateral temporal lobe ..
  7. Ottman R, Winawer M, Kalachikov S, Barker Cummings C, Gilliam T, Pedley T, et al. LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology. 2004;62:1120-6 pubmed
    S: Mutations in LGI1 cause autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of familial temporal lobe epilepsy with auditory ictal manifestations...
  8. Striano P, de Falco A, Diani E, Bovo G, Furlan S, Vitiello L, et al. A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy. Arch Neurol. 2008;65:939-42 pubmed publisher
    ..for autosomal dominant lateral temporal epilepsy have been found in the leucine-rich, glioma-inactivated 1 (LGI1) gene...
  9. Tumani H, Brettschneider J. Biochemical markers of autoimmune diseases of the nervous system. Curr Pharm Des. 2012;18:4556-63 pubmed
    ..nervous system such as contactin-2 associated protein (Caspr2) or the protein leucine-rich, glioma-inactivated 1 (LGI1)...
  10. Jarius S, Metz I, König F, Ruprecht K, Reindl M, Paul F, et al. Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case. Mult Scler. 2016;22:1541-1549 pubmed
    ..AMPAR), anti-gamma-aminobutyric acid receptors (GABABR), anti-leucine-rich, glioma-activated protein 1 (LGI1), anti-contactin-associated protein 2 (CASPR2), anti-dipeptidyl-peptidase-like protein-6 (DPPX), anti-Tr/Delta/..
  11. Serafini A, Lukas R, VanHaerents S, Warnke P, Tao J, Rose S, et al. Paraneoplastic epilepsy. Epilepsy Behav. 2016;61:51-58 pubmed publisher
    ..potassium channel (VGKC)), and channel-complex proteins (leucine rich, glioma inactivated-1 glycoprotein (LGI1) and contactin-associated protein-2 (CASPR2)) and 2) antibodies against intracellular neuronal antigens (Hu/..
  12. Italiano D, Striano P, Russo E, Leo A, Spina E, Zara F, et al. Genetics of reflex seizures and epilepsies in humans and animals. Epilepsy Res. 2016;121:47-54 pubmed publisher
    ..A single LGI1 mutation has been described in a girl with seizures evoked by auditory stimuli...
  13. Silber M. Autoimmune sleep disorders. Handb Clin Neurol. 2016;133:317-26 pubmed publisher
    ..encephalitis, associated with voltage-gated potassium channel-complex antibodies, principally against CASPR2 and LGI1, can result in profound insomnia and rapid eye movement sleep behavior disorder (RBD)...
  14. Horibata Y, Elpeleg O, Eran A, Hirabayashi Y, Savitzki D, Tal G, et al. EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans. J Lipid Res. 2018;59:1015-1026 pubmed publisher
    Ethanolamine phosphotransferase (EPT)1, also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids, such ..
  15. McKeon A, Vincent A. Autoimmune movement disorders. Handb Clin Neurol. 2016;133:301-15 pubmed publisher
    ..autoantibody targets are diverse and include neuronal surface proteins such as leucine-rich, glioma-inactivated 1 (LGI1) and glycine receptors, as well as antibodies (such as intracellular antigens) that are markers of a central ..
  16. Kaneko J, Kanazawa N, Tominaga N, Kaneko A, Suga H, Usui R, et al. Practical issues in measuring autoantibodies to neuronal cell-surface antigens in autoimmune neurological disorders: 190 cases. J Neurol Sci. 2018;390:26-32 pubmed publisher
    ..had NSA-antibodies: NMDA receptor (NMDAR) (n?=?39), AMPA receptor (n?=?3), leucine-rich glioma inactivated 1 (LGI1) (n?=?3), glycine receptor (GlyR) (n?=?3), GABA(A) receptor (n?=?2), GABA(B) receptor (n?=?1), metabotrophic ..
  17. Palacios S, Currie H, Mikkola T, Dragon E. Perspective on prescribing conjugated estrogens/bazedoxifene for estrogen-deficiency symptoms of menopause: a practical guide. Maturitas. 2015;80:435-40 pubmed publisher
    ..Unlike estrogen-progestin therapy (EPT), CE 0.45 mg/BZA 20 mg did not increase breast density compared with placebo...
  18. Karaaslan Z, Ekizoğlu E, Tektürk P, Erdağ E, Tüzün E, Bebek N, et al. Investigation of neuronal auto-antibodies in systemic lupus erythematosus patients with epilepsy. Epilepsy Res. 2017;129:132-137 pubmed publisher
    ..channel (VGKC)-complex antigens, contactin-associated protein-like 2 (CASPR-2), leucine-rich, glioma inactivated 1 (LGI1), glutamic acid decarboxylase (GAD), N-methyl-d-aspartate receptor (NMDA-R), alpha-amino-3-hydroxy-5-methyl-4-..
  19. Valdovinos M, Zavala Solares M, Coss Adame E. Esophageal hypomotility and spastic motor disorders: current diagnosis and treatment. Curr Gastroenterol Rep. 2014;16:421 pubmed publisher
    ..The introduction of high-resolution manometry (HRM) and esophageal pressure topography (EPT) has significantly enhanced the ability to diagnose EH and SMD...
  20. Greene B, Vansuch G, Chica B, Adams M, Dyer R. Applications of Photogating and Time Resolved Spectroscopy to Mechanistic Studies of Hydrogenases. Acc Chem Res. 2017;50:2718-2726 pubmed publisher
    ..the pre-steady-state kinetics revealed a distinct role of proton tunneling in concerted electron-proton transfer (EPT) modulated by a conserved glutamic acid residue...
  21. Messelmani M, Fekih Mrissa N, Zaouali J, Mrissa R. Limbic encephalitis associated with leucine-rich glioma-inactivated 1 antibodies. Ann Saudi Med. 2015;35:76-9 pubmed publisher
    ..the case of a patient with confirmed limbic encephalitis associated with leucine-rich glioma-inactivated 1 (LGI1) antibodies...
  22. Escudero D, Guasp M, Ariño H, Gaig C, Martínez Hernández E, Dalmau J, et al. Antibody-associated CNS syndromes without signs of inflammation in the elderly. Neurology. 2017;89:1471-1475 pubmed publisher
    ..Clinical manifestations included faciobrachial dystonic seizures (FBDS) in 11 of 35 (31.4%) patients, all with LGI1 antibodies; a combination of gait instability, brainstem dysfunction, and sleep disorder associated with IgLON5 ..
  23. Saari G, Wang Z, Brooks B. Revisiting inland hypoxia: diverse exceedances of dissolved oxygen thresholds for freshwater aquatic life. Environ Sci Pollut Res Int. 2018;25:3139-3150 pubmed publisher
    ..hazard assessments predicted acute invertebrate DO thresholds for Ephemeroptera, Plecoptera, or Trichoptera (EPT) taxa and species inhabiting lotic systems to be more sensitive than fish...
  24. Takahashi D, Gu F, Parada I, Vyas S, Prince D. Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma. Neurobiol Dis. 2016;91:166-81 pubmed publisher
    ..The findings are relevant for understanding the pathophysiology of neocortical post-traumatic epileptogenesis and are important in terms of the timing of potential prophylactic treatments. ..
  25. Phero J, Warren V, Fisher A, Rivera E, Saha P, Reside G, et al. Buffered 1% Lidocaine With Epinephrine Can Be as Effective as Nonbuffered 2% Lidocaine With Epinephrine for Maxillary Field Block. J Oral Maxillofac Surg. 2017;75:2071-2075 pubmed publisher
    ..The outcome variables were subjects' responses to cold and electric pulp testing (EPT) stimulation of the maxillary first molar and canine, pain levels during the injection, and time to midface ..
  26. Qin J, Diniz C, Coleman J. Pharmacy-level barriers to implementing expedited partner therapy in Baltimore, Maryland. Am J Obstet Gynecol. 2018;218:504.e1-504.e6 pubmed publisher
    ..In areas with limited geographic access to pharmacies, expedited partner therapy strategies that do not depend on partners physically accessing a pharmacy merit consideration. ..
  27. Wang Q, Roß Nickoll M, Wu D, Deng W, Wang Z, Yuan X, et al. Impervious area percentage predicated influence of rapid urbanization on macroinvertebrate communities in a southwest China river system. Sci Total Environ. 2018;627:104-117 pubmed publisher
    ..The results indicate a significant reduction in sensitive EPT (Ephemeroptera, Plecoptera and Trichoptera) species, dominance by a few tolerant taxa (Oligochaeta and Chironomidae)..
  28. Lal D, Pernhorst K, Klein K, Reif P, Tozzi R, Toliat M, et al. Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy. Epilepsia. 2015;56:e129-33 pubmed publisher
    ..Our study extends the phenotypic spectrum of RBFOX1 deletions as a risk factor for focal epilepsy and suggests that exonic RBFOX1 deletions are involved in the broad spectrum of focal and generalized epilepsies. ..
  29. Mitsugi R, Itoh T, Fujiwara R. MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury. Toxicol Lett. 2016;263:34-43 pubmed publisher
    ..Especially, SLCO4C1, PEPCK, MT1M, HIST1H2BM, LGI1, and PLA2G2A were markedly increased or decreased in the miR-877-5p overexpressing cells...
  30. Watson A, Merovich G, Petty J, Gutta J. Evaluating expected outcomes of acid remediation in an intensively mined Appalachian watershed. Environ Monit Assess. 2017;189:339 pubmed publisher
    ..Likewise, sites impaired by AMD improved in bio-condition scores with AMD treatment. EPT genera increased significantly but were lower compared to unimpaired streams...
  31. Çinar Medeni Ã, Colakoglu F, Yüce K, IpekoÄŸlu G, Baltaci G. The relation between knee muscle strength and performance tests in orienteering athletes. J Sports Med Phys Fitness. 2016;56:1261-1268 pubmed
    ..VO2max levels showed moderate correlations with DL's "flexor peak torque" (FPT) and NDL's "extensor peak torque" (EPT) and FPT values respectively (r=0.49, r=0.38, r=0.58). FPT of NDL was a predictor of VO2max level (R2=0.33)...
  32. Koninti R, Palvai S, Satpathi S, Basu S, Hazra P. Loading of an anti-cancer drug into mesoporous silica nano-channels and its subsequent release to DNA. Nanoscale. 2016;8:18436-18445 pubmed
    ..nano-channel (MCM-41) based molecular switching of a biologically important anticancer drug, namely, ellipticine (EPT) has been utilized to probe its efficient loading onto MCM-41, and its subsequent release to intra-cellular ..
  33. Ye Y, Liao S, Luo B, Ni L. Botulinum toxin treatment for essential palatal tremors presenting with nasal clicks instead of pulsatile tinnitus: a case report. Head Face Med. 2016;12:33 pubmed
    In this study, we report a rare case of an adult patient with essential palatal tremors (EPT) presenting as nasal clicks, instead of otic clicks or objective pulsatile tinnitus in common EPT...
  34. Michelucci R, Pulitano P, Di Bonaventura C, Binelli S, Luisi C, Pasini E, et al. The clinical phenotype of autosomal dominant lateral temporal lobe epilepsy related to reelin mutations. Epilepsy Behav. 2017;68:103-107 pubmed publisher
    To describe the clinical phenotype of 7 families with Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLTE) related to Reelin (RELN) mutations comparing the data with those observed in 12 LGI1-mutated pedigrees belonging to our ..
  35. Maruyama H, Oikawa R, Hayakawa M, Takamori S, Kimura Y, Abe N, et al. Chemical ligation of oligonucleotides using an electrophilic phosphorothioester. Nucleic Acids Res. 2017;45:7042-7048 pubmed publisher
    We developed a new approach for chemical ligation of oligonucleotides using the electrophilic phosphorothioester (EPT) group...
  36. Shajari M, Khalil S, Mayer W, Al Khateeb G, Böhm M, Petermann K, et al. Comparison of 2 laser fragmentation patterns used in femtosecond laser-assisted cataract surgery. J Cataract Refract Surg. 2017;43:1571-1574 pubmed publisher
    ..the effect of fragmentation patterns (pie pattern versus grid pattern) on effective phacoemulsification time (EPT). Department of Ophthalmology, Goethe University, Frankfurt am Main, Germany. Retrospective case series...
  37. Sheng Y, Hua Y, Wang X, Zhao X, Chen L, Zhou H, et al. Application of High-Density Electropulsing to Improve the Performance of Metallic Materials: Mechanisms, Microstructure and Properties. Materials (Basel). 2018;11: pubmed publisher
    ..However, the microstructure changes in electropulsing treatment (EPT) metals and alloys have not been fully explored, and the effects vary significantly on different material...
  38. Mittal M, Rabinstein A, Hocker S, Pittock S, Wijdicks E, McKeon A. Autoimmune Encephalitis in the ICU: Analysis of Phenotypes, Serologic Findings, and Outcomes. Neurocrit Care. 2016;24:240-50 pubmed publisher
    ..Thirteen Group 1 patients were seropositive for ≥1 of VGKC-complex-IgG (6; including Lgi1-IgG in 2), NMDA-R-IgG (4), AMPA-R-IgG (1), ANNA-1 (1), Ma1/Ma2 antibody (1), and PCA-1 (1)...
  39. Westin V, Klevebro S, Domellöf M, Vanpée M, Hallberg B, Stoltz Sjöström E. Improved nutrition for extremely preterm infants - A population based observational study. Clin Nutr ESPEN. 2018;23:245-251 pubmed publisher
    Extremely preterm (EPT) infants are at high risk for malnutrition due to immaturity and medical complications and they often accumulate nutritional deficits and experience growth faltering during treatment at neonatal intensive care ..
  40. Cowell J, Head K, Kunapuli P, Vaughan M, Karasik E, Foster B. Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer. Exp Mol Pathol. 2010;88:77-81 pubmed publisher
    The LGI1 gene has been implicated in tumor cell invasion through regulation of the ERK pathway...
  41. Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R. Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. Epilepsia. 2010;51:690-3 pubmed publisher
    Autosomal dominant lateral temporal lobe epilepsy (ADLTE) caused by LGI1 (leucine-rich gene, glioma-inactivated-1) mutations is a rare familial epileptic syndrome characterized by the auditory ictal manifestation and rare nocturnal ..
  42. Hatch K, Schultz T, Talamo J, Dick H. Femtosecond laser-assisted compared with standard cataract surgery for removal of advanced cataracts. J Cataract Refract Surg. 2015;41:1833-8 pubmed publisher
    To compare effective phacoemulsification time (EPT) for the removal of brunescent cataracts treated with femtosecond laser-assisted cataract surgery with standard cataract phacoemulsification techniques...
  43. Neuvonen M, Kyrklund K, Taskinen S, Koivusalo A, Rintala R, Pakarinen M. Lower urinary tract symptoms and sexual functions after endorectal pull-through for Hirschsprung disease: controlled long-term outcomes. J Pediatr Surg. 2017;52:1296-1301 pubmed publisher
    ..prevalence of lower urinary tract symptoms (LUTS) and outcomes for sexual function after endorectal pull-through (EPT) for Hirschsprung disease (HD) compared to controls. To date, similar controlled studies are lacking...
  44. Faria Correia F, Lopes B, Monteiro T, Franqueira N, Ambrosio R. Correlation between different Scheimpflug-based lens densitometry analysis and effective phacoemulsification time in mild nuclear cataracts. Int Ophthalmol. 2018;38:1103-1110 pubmed publisher
    ..the correlations between preoperative Scheimpflug-based lens densitometry and effective phacoemulsification time (EPT) in age-related nuclear cataracts. Retrospective consecutive study...
  45. Seagar M, Russier M, Caillard O, MAULET Y, Fronzaroli Molinieres L, de San Feliciano M, et al. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proc Natl Acad Sci U S A. 2017;114:7719-7724 pubmed publisher
    Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons...
  46. Cardoza R, McCormick S, Malmierca M, Olivera E, Alexander N, Monte E, et al. Effects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum. Appl Environ Microbiol. 2015;81:6355-66 pubmed publisher
    ..In the present work, the HA intermediate 12,13-epoxytrichothec-9-ene (EPT) was produced by expression of the T. arundinaceum tri4 gene in a transgenic T...
  47. Lotan I, Djaldetti R, Hellman M, Benninger F. Atypical case of Morvan's syndrome. J Clin Neurosci. 2016;25:132-4 pubmed publisher
    ..neurological symptoms, as well as disappearance of the characteristic anti-leucine-rich, glioma inactivated 1 (anti-LGI1) antibodies, the patient presented with episodes of fever of unknown origin, during which the antibodies became ..
  48. Silva D, Ligeiro R, Hughes R, Callisto M. The role of physical habitat and sampling effort on estimates of benthic macroinvertebrate taxonomic richness at basin and site scales. Environ Monit Assess. 2016;188:340 pubmed publisher
    ..effect of sampling effort on estimates of macroinvertebrate family and Ephemeroptera, Plecoptera, and Trichoptera (EPT) genera richness at two scales: basin and stream site...
  49. Savolainen Peltonen H, Tuomikoski P, Korhonen P, Hoti F, Vattulainen P, Gissler M, et al. Cardiac Death Risk in Relation to the Age at Initiation or the Progestin Component of Hormone Therapies. J Clin Endocrinol Metab. 2016;101:2794-801 pubmed publisher
    ..opportunity hypothesis" with natural estradiol alone (ET) or with various progestins in combination with estradiol (EPT)...
  50. Giannopoulos G, Kossyvakis C, Panagopoulou V, Tsiachris D, Doudoumis K, Mavri M, et al. Permanent pacemaker implantation in octogenarians with unexplained syncope and positive electrophysiologic testing. Heart Rhythm. 2017;14:694-699 pubmed publisher
    ..in patients aged 80 years or older with unexplained syncope and "positive" invasive electrophysiologic testing (EPT). This was an observational study...
  51. Tröscher A, Klang A, French M, Quemada Garrido L, Kneissl S, Bien C, et al. Selective Limbic Blood-Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies. Front Immunol. 2017;8:1364 pubmed publisher
    Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC) ..
  52. Thomas R, Favell K, Morante Redolat J, Pool M, Kent C, Wright M, et al. LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci. 2010;30:6607-12 pubmed publisher
    Mutations in leucine-rich glioma inactivated (LGI1) are a genetic cause of autosomal dominant temporal lobe epilepsy with auditory features...
  53. Dazzo E, Santulli L, Posar A, Fattouch J, Conti S, Lodén van Straaten M, et al. Autosomal dominant lateral temporal epilepsy (ADLTE): novel structural and single-nucleotide LGI1 mutations in families with predominant visual auras. Epilepsy Res. 2015;110:132-8 pubmed publisher
    Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by prominent auditory or aphasic symptoms. Mutations in LGI1 account for less than 50% of ADLTE families...
  54. Eisen R, Dennis D, Gage K. The Role of Early-Phase Transmission in the Spread of Yersinia pestis. J Med Entomol. 2015;52:1183-92 pubmed publisher
    Early-phase transmission (EPT) of Yersinia pestis by unblocked fleas is a well-documented, replicable phenomenon with poorly defined mechanisms...
  55. Lallement M, Macchi P, Vigliano P, Juarez S, Rechencq M, Baker M, et al. Rising from the ashes: Changes in salmonid fish assemblages after 30 months of the Puyehue-Cordon Caulle volcanic eruption. Sci Total Environ. 2016;541:1041-1051 pubmed publisher
    ..In west sites, increased Chironomid densities were recorded 8 months after the initial eruption as well as low EPT index values. These relationships were reversed in the less affected streams farther away from the volcano...
  56. Smith S, Xu L, Kasten M, Anderson M. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J Neurochem. 2012;120:611-21 pubmed publisher
    ..Importantly, leucine-rich glioma-inactivated-1 (LGI1), a secreted synaptic protein mutated to cause human partial epilepsy, regulated this seizure-induced circuit ..
  57. Okah E, Arya V, Rogers M, Kim M, Schillinger J. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. Sex Transm Dis. 2017;44:104-108 pubmed publisher
    Expedited partner therapy (EPT) for Chlamydia trachomatis (Ct) is the practice of providing Ct-infected patients with medication, or prescription (prescription-EPT) to deliver to their sex partners without first examining those partners...
  58. Gass M, Larson J, Cochrane B, Manson J, Lane D, Barnabei V, et al. Sexual activity and vaginal symptoms in the postintervention phase of the Women's Health Initiative Hormone Therapy Trials. Menopause. 2017;: pubmed publisher
    ..of discontinuing oral hormone therapy (HT) on sexual activity, vaginal symptoms, and sexual activity components among participants in the estrogen-progestin therapy (EPT) and estrogen therapy (ET) trial of the Women's Health Initiative.
  59. Tan G, Kondo T, Murakami N, Imamura K, Enami T, Tsukita K, et al. Induced pluripotent stem cells derived from an autosomal dominant lateral temporal epilepsy (ADLTE) patient carrying S473L mutation in leucine-rich glioma inactivated 1 (LGI1). Stem Cell Res. 2017;24:12-15 pubmed publisher
    Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited epileptic syndrome, and it is associated with mutations of leucine-rich glioma inactivated 1 (LGI1) gene...
  60. Luo K, Hu X, He Q, Wu Z, Cheng H, Hu Z, et al. Impacts of rapid urbanization on the water quality and macroinvertebrate communities of streams: A case study in Liangjiang New Area, China. Sci Total Environ. 2018;621:1601-1614 pubmed publisher
    ..The sensitive species (e.g., EPT taxa) were mainly centralized at LUL sites, whereas tolerant species, such as Tubificidae (17.3%), Chironomidae (12...
  61. Yuzaki M. Two Classes of Secreted Synaptic Organizers in the Central Nervous System. Annu Rev Physiol. 2018;80:243-262 pubmed publisher
    ..These include Lgi1, Cbln1, neuronal pentraxins, Hevin, thrombospondins, and glypicans...
  62. Pizzuti A, Flex E, Di Bonaventura C, Dottorini T, Egeo G, Manfredi M, et al. Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism. Ann Neurol. 2003;53:396-9 pubmed
    Autosomal dominant partial epilepsy with auditory features (ADPEAF) is a genetically heterogeneous disorder. Some patients exhibit mutations in the leucine-rich glioma inactivated (LGI1) gene...
  63. Di Bonaventura C, Operto F, Busolin G, Egeo G, D Aniello A, Vitello L, et al. Low penetrance and effect on protein secretion of LGI1 mutations causing autosomal dominant lateral temporal epilepsy. Epilepsia. 2011;52:1258-64 pubmed publisher
    ..DNAs from family members were screened for LGI1 mutations. The effects of mutations on Lgi1 protein secretion were determined in transfected culture cells...
  64. Manna I, Mumoli L, Labate A, Citrigno L, Ferlazzo E, Aguglia U, et al. Autosomal dominant lateral temporal epilepsy (ADLTE): absence of chromosomal rearrangements in LGI1 gene. Epilepsy Res. 2014;108:597-9 pubmed publisher
    ..1 (LGI1) gene are found in about half of the families with autosomal dominant lateral temporal epilepsy (ADLTE)...
  65. Heiman G, Kamberakis K, Gill R, Kalachikov S, Pedley T, Hauser W, et al. Evaluation of depression risk in LGI1 mutation carriers. Epilepsia. 2010;51:1685-90 pubmed publisher
    ..partial epilepsy with auditory features caused by mutations in the leucine-rich, glioma inactivated 1 gene (LGI1)...
  66. Schimmel M, Frühwald M, Bien C. Limbic encephalitis with LGI1 antibodies in a 14-year-old boy. Eur J Paediatr Neurol. 2018;22:190-193 pubmed publisher
    Limbic encephalitis (LE) with antibodies against leucine-rich glioma inactivated protein 1 (LGI1) is an auto-antibody mediated disorder with characteristic symptoms as dysfunction of memory, faciobrachial dystonic seizures and ..
  67. Leonardi E, Dazzo E, Aspromonte M, Tabaro F, Pascarelli S, Tosatto S, et al. CNTNAP2 mutations and autosomal dominant epilepsy with auditory features. Epilepsy Res. 2018;139:51-53 pubmed publisher
    ..Mutations in LGI1 and RELN genes account for the disorder in about 50% of ADEAF families...
  68. Zhu Y, Liu H, Zhang L, Zeng T, Song Y, Qin Y, et al. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma. Carcinogenesis. 2014;35:1154-61 pubmed publisher
    Here, we report the characterization of a candidate tumor suppressor gene leucine-rich glioma inactivated 1 (LGI1) in human esophageal squamous cell carcinoma (ESCC)...
  69. Wang K, Li F, Chen L, Lai Y, Zhang X, Li H. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget. 2017;8:81109-81124 pubmed publisher
    ..02 (95% CI = 1.02-1.02). Moreover, RR for current estrogen plus progestin therapy (EPT) users was 1.76, (95% CI = 1.56-1.96), and for per year increases was 1.08 (95% CI = 1.08-1.08)...
  70. Hedera P, Abou Khalil B, Crunk A, Taylor K, Haines J, Sutcliffe J. Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 gene. Epilepsia. 2004;45:218-22 pubmed
    ..LGI1) were recently described in a small number of families with autosomal dominant lateral temporal epilepsy (ADLTE)...
  71. Bisulli F, Tinuper P, Scudellaro E, Naldi I, Bagattin A, Avoni P, et al. A de novo LGI1 mutation in sporadic partial epilepsy with auditory features. Ann Neurol. 2004;56:455-6 pubmed
  72. Klein K, Pendziwiat M, Cohen R, Appenzeller S, de Kovel C, Rosenow F, et al. Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. J Neurol. 2016;263:11-6 pubmed publisher
    ..We performed linkage analysis and exome sequencing. LGI1, KANK1 and RELN were Sanger sequenced. Seizure semiology of 11 individuals was consistent with ADEAF...
  73. van Sonderen A, Roelen D, Stoop J, Verdijk R, Haasnoot G, Thijs R, et al. Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4. Ann Neurol. 2017;81:193-198 pubmed publisher
    Leucine-rich glioma-inactivated1 (LGI1) encephalitis is an antibody-associated inflammation of the limbic area. An autoimmune etiology is suspected but not yet proven...
  74. de Bellescize J, Boutry N, Chabrol E, André Obadia N, Arzimanoglou A, LeGuern E, et al. A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes. Epilepsy Res. 2009;85:118-22 pubmed publisher
    Mutations in LGI1 have been reported in several families with autosomal dominant lateral temporal epilepsy. In a family in which three patients also experienced migraine-like episodes we found a novel three base-pair deletion (c...
  75. CRANE S, Backus L, Stockman B, Carpenter J, Lin L, Haase J. Understanding Treatment Burden and Quality of Life Impact of Participating in an Early-Phase Pediatric Oncology Clinical Trial: A Pilot Study. J Pediatr Oncol Nurs. 2018;35:25-35 pubmed publisher
    ..Despite the extensive use of EPTs in pediatric oncology, little is known about parent and child experiences during EPT participation...
  76. Balint B, Vincent A, Meinck H, Irani S, Bhatia K. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2017;: pubmed publisher
    ..spectrum disorders with GAD, glycine receptor, amphiphysin or DPPX antibodies, specific paroxysmal dystonias with LGI1 antibodies, and cerebellar ataxia with various anti-neuronal antibodies...
  77. Fertig E, Lincoln A, Martinuzzi A, Mattson R, Hisama F. Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features. Neurology. 2003;60:1687-90 pubmed
    Autosomal dominant partial epilepsy with auditory features (ADPEAF) is a rare idiopathic epilepsy syndrome caused by mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene...
  78. Di Bonaventura C, Carni M, Diani E, Fattouch J, Vaudano E, Egeo G, et al. Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1mutation: electroclinical, genetic, and EEG/fMRI findings. Epilepsia. 2009;50:2481-6 pubmed publisher
    We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic ..
  79. Wan Z, Lu S, Zhao D, Ding Y, Chen P. Arginine-rich ionic complementary peptides as potential drug carriers: Impact of peptide sequence on size, shape and cell specificity. Nanomedicine. 2016;12:1479-88 pubmed publisher
    ..peptide length has a pronounced impact on the morphology of peptide complex with the anticancer drug ellipticine (EPT), and the amino acid arrangement affects the complex size...
  80. Kim T, Lee S, Moon J, Sunwoo J, Byun J, Lim J, et al. Anti-LGI1 encephalitis is associated with unique HLA subtypes. Ann Neurol. 2017;81:183-192 pubmed publisher
    Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal ..
  81. Wennberg R, Steriade C, Chen R, Andrade D. Frontal infraslow activity marks the motor spasms of anti-LGI1 encephalitis. Clin Neurophysiol. 2018;129:59-68 pubmed publisher
    The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies...
  82. Ho Y, Ionita Laza I, Ottman R. Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF. Neurology. 2012;78:563-8 pubmed publisher
    ..mapped to one of the gene's 2 major functional domains, N-terminal leucine-rich repeats (LRRs) and C-terminal epitempin (EPTP) repeats, and classified according to predicted effect on the encoded protein (truncation vs missense)...
  83. Reid A, Rogers M, Arya V, Edelstein Z, Schillinger J. Pharmacists' Knowledge and Practices Surrounding Expedited Partner Therapy for Chlamydia trachomatis, New York City, 2012 and 2014. Sex Transm Dis. 2016;43:679-684 pubmed
    ..for a patient's partner without the partner having a medical evaluation ("prescription-expedited partner therapy" [EPT]), and use of prescription-EPT is common...
  84. Mooney R, Abdul Majid A, Batalla J, Annala A, Aboody K. Cell-mediated enzyme prodrug cancer therapies. Adv Drug Deliv Rev. 2017;118:35-51 pubmed publisher
    ..Here we discuss the current pre-clinical and clinical use of cell-mediated enzyme prodrug therapy (EPT) directed against solid tumors and avenues for further development...
  85. Ahn S, Kim D, Park S. Efficacy of Ultrasound Doppler Flowmetry in Assessing Pulp Vitality of Traumatized Teeth: A Propensity Score Matching Analysis. J Endod. 2018;44:379-383 pubmed publisher
    ..to evaluate and compare the efficacy of ultrasound Doppler flowmetry (UDF) with that of electric pulp testing (EPT) in assessing pulp vitality in traumatized teeth...
  86. Leonardi E, Andreazza S, Vanin S, Busolin G, Nobile C, Tosatto S. A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS ONE. 2011;6:e18142 pubmed publisher
    Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome...
  87. Tofaris G, Irani S, Cheeran B, Baker I, Cader Z, Vincent A. Immunotherapy-responsive chorea as the presenting feature of LGI1-antibody encephalitis. Neurology. 2012;79:195-6 pubmed publisher
  88. Naddeo C, Vertuccio L, Barra G, Guadagno L. Nano-Charged Polypropylene Application: Realistic Perspectives for Enhancing Durability. Materials (Basel). 2017;10: pubmed publisher
    ..The extent of the IP is strictly correlated to the amount of MWCNTs. The low electrical percolation threshold (EPT) and the electrical conductivity of the nanocomposites, together with their excellent thermal and photooxidative ..
  89. Gambacciani M, Biglia N, Cagnacci A, Caruso S, Cicinelli E, De Leo V, et al. Menopause and hormone replacement therapy: the 2017 Recommendations of the Italian Menopause Society. Minerva Ginecol. 2018;70:27-34 pubmed publisher
    ..The term HRT typically includes estrogen replacement therapy (ERT) and estrogen-progestogen therapy (EPT)...
  90. Bastiaansen A, van Sonderen A, Titulaer M. Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies). Curr Opin Neurol. 2017;30:302-309 pubmed publisher
    ..are not directed at the VGKC itself but to two closely associated proteins, anti-leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2)...
  91. Mikhail M, Flanders M. Clinical profiles and surgical outcomes of adult esotropia. Can J Ophthalmol. 2017;52:403-408 pubmed publisher
    ..into group 1 (35 with childhood-onset esotropia [CET]) and group 2 (38 with adult-onset esophoria-tropia [EPT])...