leptin receptor


Gene Symbol: leptin receptor
Description: leptin receptor
Alias: CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor, OB receptor, huB219
Species: human
Products:     leptin receptor

Top Publications

  1. Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, et al. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab. 2002;87:4587-94 pubmed
    ..is bound in human blood by a high affinity binding protein, which appears to be identical with the soluble leptin receptor (sOB-R)...
  2. Duarte S, Francischetti E, Genelhu Abreu V, Barroso S, Braga J, Cabello P, et al. p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. Am J Hum Biol. 2006;18:448-53 pubmed
    ..92 and a 95% confidence interval of 1.15-3.22 (P = 0.013). There is a strong association of the LEPR p.Q223R gene polymorphism with obesity in Brazil. ..
  3. Han C, Shi J, Du L, Jing J, Zhao X, Tian B, et al. [Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer]. Zhonghua Liu Xing Bing Xue Za Zhi. 2007;28:136-40 pubmed
    To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer...
  4. Han C, Du L, Jing J, Zhao X, Tian F, Tian B, et al. [Relationship between the mutation of leptin receptor gene and tumorigenesis of breast cancer]. Zhonghua Zhong Liu Za Zhi. 2011;33:207-11 pubmed
    The aim of this study was to investigate the relationship of the mutations of leptin receptor gene exon 4, exon 6, exon9, and exon20 with the tumorigenesis of breast cancer...
  5. Masuo K, Straznicky N, Lambert G, Katsuya T, Sugimoto K, Rakugi H, et al. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res. 2008;31:1093-100 pubmed publisher
    ..We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity. ..
  6. Guízar Mendoza J, Amador Licona N, Flores Martinez S, López Cardona M, Ahuatzin Trémary R, Sanchez Corona J. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. J Hum Hypertens. 2005;19:341-6 pubmed
    Polymorphisms of leptin receptor (LEPR) may contribute to a common form of obesity and, as a consequence, obesity-related diseases...
  7. Mattevi V, Zembrzuski V, Hutz M. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-85 pubmed
    ..001). Our findings suggest that genetic variability in the leptin receptor and neuropeptide Y genes is implicated in body weight regulation, the LEPR Gln223Arg variant being associated ..
  8. Brandl E, Frydrychowicz C, Tiwari A, Lett T, Kitzrow W, Buttner S, et al. Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38:134-41 pubmed publisher
    ..Previous studies have indicated an impact of genetic variation in the genes encoding leptin, LEP, and leptin receptor, LEPR, on AIWG, but results have not been conclusive...
  9. Lu J, Zou D, Zheng L, Chen G, Lu J, Feng Z. Synergistic effect of LEP and LEPR gene polymorphism on body mass index in a Chinese population. Obes Res Clin Pract. 2013;7:e445-9 pubmed publisher
    Both leptin (LEP) and leptin receptor (LEPR) are important in the regulation of body weight...

More Information

Publications110 found, 100 shown here

  1. Kim K, Shin A, Lee Y, Kim S, Kim Y, Lee E. Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women. Hum Reprod. 2012;27:2193-200 pubmed publisher
    ..Ten single nucleotide polymorphisms (SNPs) in the leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma (PPAR?) genes were investigated to evaluate their ..
  2. Riolfi M, Ferla R, Del Valle L, Pina Oviedo S, Scolaro L, Micciolo R, et al. Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol. 2010;20:481-9 pubmed publisher
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  3. Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18:1354-62 pubmed
    Soluble leptin receptor (SLR) represents the major leptin binding activity in plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding of membrane-spanning receptors...
  4. Slattery M, Wolff R, Herrick J, Caan B, Potter J. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. Int J Cancer. 2008;122:1611-7 pubmed
    ..We evaluated the LEP rs2167270 (19 G > A) and rs7799039 (-2548 G > A) polymorphisms and the leptin receptor, LEPR rs6588147 (located in intron 2), polymorphism with risk of developing colon cancer in a study of 1,567 ..
  5. Gu P, Jiang W, Chen M, Lu B, Shao J, Du H, et al. Association of leptin receptor gene polymorphisms and essential hypertension in a Chinese population. J Endocrinol Invest. 2012;35:859-65 pubmed publisher
    The leptin receptor (LEPR) is an important regulator of leptin activity and resistance...
  6. Kagawa Y, Dever G, Otto C, Charupoonphol P, Supannatas S, Yanagisawa Y, et al. Single nucleotide polymorphism and lifestyle-related diseases in the Asia-Pacific region: comparative study in Okinawa, Palau and Thailand. Asia Pac J Public Health. 2003;15 Suppl:S10-4 pubmed
    ..four populations, in both men and women: uncoupling protein 2 (UCP2), uncoupling protein 3 promoter (UCP3p), leptin receptor (LEPR) exon 6, and angiotensinogen (AGTa-20c)...
  7. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, et al. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Hum Genet. 2010;127:287-94 pubmed publisher
    ..of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (..
  8. Wang B, Fu E, Cao Y, Zhong Y, Fu G, Tian X, et al. Effect of leptin receptor mutation on the development of chronic bronchitis. Asia Pac J Public Health. 2013;25:80S-7S pubmed publisher
    To investigate the effect of serum leptin level and leptin receptor (Lepr) genetic mutation on chronic bronchitis, we measured the serum leptin levels of 236 patients with chronic bronchitis and 107 healthy controls by ELISA, the ..
  9. Stefan N, Vozarova B, Del Parigi A, Ossowski V, Thompson D, Hanson R, et al. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int J Obes Relat Metab Disord. 2002;26:1629-32 pubmed
    ..Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR...
  10. Oh H, Choi Y, Yang Y, Kim J, Leung P, Choi J. Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. Mol Hum Reprod. 2013;19:160-8 pubmed publisher
    ..This study investigated the expression of the leptin receptor (ObR) in endometrioma tissues and immortalized endometriotic cells, and the effect of leptin on cell growth...
  11. van Rossum C, Hoebee B, van Baak M, Mars M, Saris W, Seidell J. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res. 2003;11:377-86 pubmed
    To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain...
  12. de Luis Roman D, de la Fuente R, Sagrado M, Izaola O, Vicente R. Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients. Arch Med Res. 2006;37:854-9 pubmed
    ..The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on leptin response and weight loss secondary to a lifestyle modification (Mediterranean hypocaloric diet ..
  13. Kote Jarai Z, Singh R, Durocher F, Easton D, Edwards S, Ardern Jones A, et al. Association between leptin receptor gene polymorphisms and early-onset prostate cancer. BJU Int. 2003;92:109-12 pubmed
    To report a case-control study examining the relationship between polymorphisms in the leptin receptor (OBR) gene and the development of young-onset prostate cancer, because epidemiological studies report that prostate cancer risk is ..
  14. Chiu K, Chu A, Chuang L, Saad M. Association of leptin receptor polymorphism with insulin resistance. Eur J Endocrinol. 2004;150:725-9 pubmed
    Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown...
  15. Willett E, Skibola C, Adamson P, Skibola D, Morgan G, Smith M, et al. Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer. 2005;93:811-6 pubmed
    ..9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL risk, as well as a polymorphism in the energy ..
  16. Giandomenico G, Dellas C, Czekay R, Koschnick S, Loskutoff D. The leptin receptor system of human platelets. J Thromb Haemost. 2005;3:1042-9 pubmed
    ..study examines the effect of leptin on human platelets, and provides initial insights into the nature of the leptin receptor on these platelets...
  17. Zhang Y, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, et al. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis. 2007;191:121-7 pubmed
    ..To investigate this hypothesis, we examined the effect of genetic variability at the leptin receptor (LEPR) locus on the plasma levels of fibrinogen and CRP--two markers of inflammation and susceptibility to ..
  18. Doecke J, Zhao Z, Stark M, Green A, Hayward N, Montgomery G, et al. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol Biomarkers Prev. 2008;17:1007-12 pubmed publisher
    ..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis. ..
  19. Labayen I, Ruiz J, Moreno L, Ortega F, Beghin L, Dehenauw S, et al. The effect of ponderal index at birth on the relationships between common LEP and LEPR polymorphisms and adiposity in adolescents. Obesity (Silver Spring). 2011;19:2038-45 pubmed publisher
    ..ponderal index (PI) at birth on the relationships between eight common polymorphisms of the leptin (LEP) and leptin receptor (LEPR) genes and adiposity in adolescents. A total of 823 European adolescents (45.4% girls) aged 14.8 ± 1...
  20. Gan R, Yang S. The 223A>G polymorphism of the leptin receptor gene is associated with macroangiopathy in type 2 diabetes mellitus. Mol Biol Rep. 2012;39:4759-64 pubmed publisher
    To determine whether leptin receptor (LEPR) 223A>G polymorphism has an effect on the plasma leptin levels and the macroangiopathic complications in type 2 diabetes mellitus (T2DM)...
  21. Pechlivanis S, Bermejo J, Pardini B, Naccarati A, Vodickova L, Novotny J, et al. Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol. 2009;160:933-40 pubmed publisher
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
  22. Okada T, Ohzeki T, Nakagawa Y, Sugihara S, Arisaka O. Impact of leptin and leptin-receptor gene polymorphisms on serum lipids in Japanese obese children. Acta Paediatr. 2010;99:1213-7 pubmed publisher
    ..We investigated the association between serum lipids and leptin/leptin receptor (LEPR) gene polymorphisms in obese Japanese children...
  23. Ingelsson E, Larson M, Yin X, Wang T, Meigs J, Lipinska I, et al. Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. J Clin Endocrinol Metab. 2008;93:3149-57 pubmed publisher
    The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown...
  24. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga Koda L, Golaszewska J, et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res. 2006;12:1447-53 pubmed
    ..system could become a target in breast cancer therapy, we examined the expression of leptin and its receptor (ObR) in primary and metastatic breast cancer and noncancer mammary epithelium...
  25. Sun Q, van Dam R, Meigs J, Franco O, Mantzoros C, Hu F. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. Diabetes. 2010;59:611-8 pubmed publisher
    We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two ..
  26. Takahashi Yasuno A, Masuzaki H, Miyawaki T, Ogawa Y, Matsuoka N, Hayashi T, et al. Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res Clin Pract. 2003;62:169-75 pubmed
    To investigate whether leptin receptor (Ob-R) Arg223Gln polymorphism influences serum lipid levels and whether this polymorphism affects the efficiency of the cholesterol lowering HMG-CoA reductase inhibitor, simvastatin [Clin. Cardiol...
  27. Stratigopoulos G, LeDuc C, Matsuoka N, Gutman R, Rausch R, Robertson S, et al. Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring). 2009;17:126-35 pubmed publisher
    ..We conclude that Q223R is unlikely to play a significant role in regulation of human adiposity. This approach to vetting of human allelic variation might be more widely used. ..
  28. Dehghan A, Dupuis J, Barbalic M, Bis J, Eiriksdottir G, Lu C, et al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011;123:731-8 pubmed publisher
    ..We identified 18 loci that were associated with CRP levels. Our study highlights immune response and metabolic regulatory pathways involved in the regulation of chronic inflammation. ..
  29. Mergen H, Karaaslan C, Mergen M, Deniz Ozsoy E, Ozata M. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Endocr J. 2007;54:89-94 pubmed
    ..in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair ..
  30. Abete I, Goyenechea E, Crujeiras A, Martinez J. Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers. Arch Med Res. 2009;40:306-10 pubmed publisher
    Carrying variants on the leptin receptor gene (LEPR) may have an impact on inflammatory and stress markers...
  31. Park K, Shin H, Park B, Cheong H, Cho Y, Lee H, et al. Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM. J Hum Genet. 2006;51:85-91 pubmed
    ..Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorphisms of the leptin receptor gene (LEPR) ..
  32. Woo H, Park H, Ki C, Park Y, Bae W. Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea. Cancer Lett. 2006;237:137-42 pubmed
    Leptin plays an important role in the regulation of body fat homeostasis, and potential associations of leptin receptor gene (LEPR) polymorphisms with obesity have been suggested. Obesity is considered to relate to breast cancer...
  33. Portoles O, Sorlí J, Frances F, Coltell O, Gonzalez J, Saiz C, et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol. 2006;21:605-12 pubmed
    ..In animal models, the leptin (LEP) and the leptin receptor (LEPR) genes have been shown to be very important in obesity because leptin functions as a negative feedback ..
  34. Zabeau L, Defeau D, Iserentant H, Vandekerckhove J, Peelman F, Tavernier J. Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains. J Biol Chem. 2005;280:22632-40 pubmed
    The leptin receptor (LR) complex is composed of a single subunit belonging to the class I cytokine receptor family and exists as a preformed complex...
  35. Qu Y, Yang Z, Jin F, Sun L, Feng J, Tang L, et al. The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese. Diabetes Res Clin Pract. 2008;81:33-7 pubmed publisher
    b>Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM)...
  36. Jope T, Lammert A, Kratzsch J, Paasch U, Glander H. Leptin and leptin receptor in human seminal plasma and in human spermatozoa. Int J Androl. 2003;26:335-41 pubmed
    ..01) and supports this finding. Furthermore, a soluble leptin receptor (145 kDa) was found in human seminal plasma in the same specimen...
  37. Snoussi K, Strosberg A, Bouaouina N, Ben Ahmed S, Helal A, Chouchane L. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer. 2006;6:38 pubmed
    ..Our results indicated that the polymorphisms in LEP and LEPR genes are associated with increased breast cancer risk as well as disease progress, supporting our hypothesis for leptin involvement in cancer pathogenesis. ..
  38. Wasik M, Gorska E, Popko K, Pawelec K, Matysiak M, Demkow U. The Gln223Arg polymorphism of the leptin receptor gene and peripheral blood/bone marrow leptin level in leukemic children. J Physiol Pharmacol. 2006;57 Suppl 4:375-83 pubmed
    ..Leptin also plays a role in hematopoiesis, cell cycle regulation, and in oncogenesis. The leptin receptor is a single transmembrane protein belonging to the superfamily of cytokine receptors, structurally related to ..
  39. Salopuro T, Pulkkinen L, Lindstrom J, Eriksson J, Valle T, Hamalainen H, et al. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study. Int J Obes (Lond). 2005;29:1245-51 pubmed
    Genetic variation in leptin receptor (LEPR) gene has been reported to associate with insulin and glucose metabolism and adiposity in different study settings and various populations...
  40. Belouzard S, Rouille Y. Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis. EMBO J. 2006;25:932-42 pubmed
    ..We propose that mono-ubiquitin conjugates act as internalization motifs for clathrin-dependent endocytosis of leptin receptor OB-Ra.
  41. de Krom M, van der Schouw Y, Hendriks J, Ophoff R, van Gils C, Stolk R, et al. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes. 2007;56:276-80 pubmed
    ..Obese carriers of common allelic variations in leptin or the leptin receptor gene had an increased risk to display extreme snacking behavior...
  42. Wauman J, de Smet A, Catteeuw D, Belsham D, Tavernier J. Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways. Mol Endocrinol. 2008;22:965-77 pubmed publisher
    Leptin is an adipokine that regulates food intake and energy expenditure by activating its hypothalamic leptin receptor (LR)...
  43. Cleveland R, Gammon M, Long C, Gaudet M, Eng S, Teitelbaum S, et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat. 2010;120:745-52 pubmed publisher
    ..Leptin exerts its effects through interaction with the leptin receptor (LEPR)...
  44. Riestra P, Garcia Anguita A, Schoppen S, Lopez Simon L, De Oya M, Garces C. Sex-specific association between leptin receptor polymorphisms and leptin levels and BMI in healthy adolescents. Acta Paediatr. 2010;99:1527-30 pubmed publisher
    To examine the relationship of three common polymorphisms in the leptin receptor (LEPR) gene, implicated in the regulation of body weight, with leptin levels and obesity-related phenotypes in a population-based sample of healthy pubertal ..
  45. He B, Pan Y, Zhang Y, Xu Y, Wang S. Effect of LEPR Gln223Arg polymorphism on breast cancer risk in different ethnic populations: a meta-analysis. Mol Biol Rep. 2012;39:3117-22 pubmed publisher
    Leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression...
  46. Gavrila A, Peng C, Chan J, Mietus J, Goldberger A, Mantzoros C. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab. 2003;88:2838-43 pubmed
    ..These data suggest that adiponectin and sOB-R levels might be influenced by common regulatory factors and challenge the notion that cortisol may have a direct inhibitory effect on adiponectin in humans. ..
  47. Belouzard S, Delcroix D, Rouille Y. Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. J Biol Chem. 2004;279:28499-508 pubmed
    The leptin receptor is mainly localized in intracellular compartments in target tissues...
  48. Ogawa T, Hirose H, Yamamoto Y, Nishikai K, Miyashita K, Nakamura H, et al. Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism. 2004;53:879-85 pubmed
    ..One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin...
  49. Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. Am J Epidemiol. 2005;162:101-14 pubmed
    ..Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG ..
  50. Wang T, Huang M, Chang W, Ko A, Tsai E, Liu C, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14:183-7 pubmed
    ..G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity...
  51. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia. 2007;39:22-7 pubmed
    The aim of our study was to investigate the relationships between the expression of leptin, leptin receptor in the testis and spermatogenesis, and testosterone (T) concentration in infertile men...
  52. Gallicchio L, McSorley M, Newschaffer C, Huang H, Thuita L, Hoffman S, et al. Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Cancer Detect Prev. 2007;31:95-101 pubmed
    ..The findings suggest that specific polymorphisms in the PON1 and LEPR genes may play a role in progression of BBD to breast cancer among post-menopausal Caucasian women. ..
  53. Chia V, Newcomb P, Lampe J, White E, Mandelson M, McTiernan A, et al. Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2007;16:2697-703 pubmed
    ..leptin concentrations and colorectal adenoma risk; in addition, we evaluated the relationship between leptin receptor polymorphisms and adenoma risk...
  54. Hancock A, Witonsky D, Gordon A, Eshel G, Pritchard J, Coop G, et al. Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet. 2008;4:e32 pubmed publisher
    ..Nevertheless, our results are consistent with the idea that climate has been an important selective pressure acting on candidate genes for common metabolic disorders. ..
  55. Iciek R, Wender Ozegowska E, Seremak Mrozikiewicz A, Drews K, Sodowski K, Pietryga M, et al. Leptin gene, leptin gene polymorphisms and body weight in pregnant women with diabetes mellitus type I. J Physiol Pharmacol. 2008;59 Suppl 4:19-31 pubmed
    ..There were no specific differences found in selected first trimester metabolic parameters in relation to patients' genotypes. ..
  56. Okobia M, Bunker C, Garte S, Zmuda J, Ezeome E, Anyanwu S, et al. Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control study. BMC Cancer. 2008;8:338 pubmed publisher
    ..a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family...
  57. Moore S, Leitzmann M, Albanes D, Weinstein S, Snyder K, Virtamo J, et al. Adipokine genes and prostate cancer risk. Int J Cancer. 2009;124:869-76 pubmed publisher
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis. ..
  58. Ben Ali S, Kallel A, Sediri Y, Ftouhi B, Feki M, Slimene H, et al. LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients. Arch Med Res. 2009;40:186-90 pubmed publisher
    The leptin receptor (LEPR) plays a crucial role in the regulation of body weight. Several common polymorphisms have been described in the human LEPR gene including the p.Q223R polymorphism (rs1137101)...
  59. Bender N, Allemann N, Marek D, Vollenweider P, Waeber G, Mooser V, et al. Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study. PLoS ONE. 2011;6:e26157 pubmed publisher
    Three non-synonymous single nucleotide polymorphisms (Q223R, K109R and K656N) of the leptin receptor gene (LEPR) have been tested for association with obesity-related outcomes in multiple studies, showing inconclusive results...
  60. Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. PLoS ONE. 2012;7:e34787 pubmed publisher
    The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans...
  61. Misra M, Miller K, Almazan C, Ramaswamy K, Aggarwal A, Herzog D, et al. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab. 2004;89:3486-95 pubmed
    ..The soluble leptin receptor (sOB-R) is the main leptin binding protein, and the ratio of serum leptin to sOB-R provides a measure of the ..
  62. Stein K, Vasquez Garibay E, Kratzsch J, Romero Velarde E, Jahreis G. Influence of nutritional recovery on the leptin axis in severely malnourished children. J Clin Endocrinol Metab. 2006;91:1021-6 pubmed
    Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood...
  63. Rigo J, Szendei G, Rosta K, Fekete A, Bögi K, Molvarec A, et al. Leptin receptor gene polymorphisms in severely pre-eclamptic women. Gynecol Endocrinol. 2006;22:521-5 pubmed
    Variants of the leptin receptor gene (LEPR) may modulate the effect of elevated serum leptin levels in pre-eclampsia...
  64. Fairbrother U, Tanko L, Walley A, Christiansen C, Froguel P, Blakemore A. Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Miner Res. 2007;22:544-50 pubmed
    ..We carried out a population-based study of 1430 women. Three well-known nonsynonymous leptin receptor (LEPR) SNPs (Lys109Arg, Gln223Arg, and Lys656Asn) were genotyped for qualitative and quantitative association ..
  65. Liu C, Chang Y, Cheng S, Chern S, Yang T, Lee J, et al. The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. Oncology. 2007;72:75-81 pubmed
    We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer...
  66. Duarte S, Francischetti E, Genelhu V, Cabello P, Pimentel M. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects. Genet Mol Res. 2007;6:1035-43 pubmed
    ..The adrenergic receptor beta3 (beta3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and ..
  67. Han C, Du L, Jing J, Zhao X, Tian F, Shi J, et al. Associations among lipids, leptin, and leptin receptor gene Gin223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res. 2008;126:38-48 pubmed publisher
    We evaluated the relationship among the leptin receptor (LEPR) gene Gln223Arg polymorphism, body mass index (BMI), waist and hip circumference ratio (WHR), dietary structure, lifestyle, and other biomarkers with breast cancer and ..
  68. Zhao C, Liu D, Li H, Jiang L, Dai L. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Spine (Phila Pa 1976). 2008;33:E858-64 pubmed publisher
    ..There is evidence showing that chondrocytes express leptin and functional leptin receptor, and leptin stimulates chondrocyte proliferation in vitro and may play a role in the pathogenesis of ..
  69. Gottlieb M, Bodanese L, Leite L, Schwanke C, Piccoli J, da Rocha M, et al. Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. Metab Syndr Relat Disord. 2009;7:341-8 pubmed publisher
    ..886, P = 0.019) and MS (chi(2) = 14.941, P = 0.001) when compared to the HG group. This study provides evidence for a role of the LEPR gene Gln223Arg polymorphism in predisposition to metabolic syndrome in the elderly. ..
  70. Elliott P, Chambers J, Zhang W, Clarke R, Hopewell J, Peden J, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009;302:37-48 pubmed publisher
    ..The lack of concordance between the effect on coronary heart disease risk of CRP genotypes and CRP levels argues against a causal association of CRP with coronary heart disease. ..
  71. Pyrzak B, Wisniewska A, Kucharska A, Wasik M, Demkow U. No association of LEPR Gln223Arg polymorphism with leptin, obesity or metabolic disturbances in children. Eur J Med Res. 2009;14 Suppl 4:201-4 pubmed
    The aim of the study was to investigate whether the Gln223Arg in the leptin receptor may influence body weight, leptin concentration, and metabolic parameters in children...
  72. Shapiro N, Khankin E, van Meurs M, Shih S, Lu S, Yano M, et al. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010;185:517-24 pubmed publisher
    ..endotoxemia and cecal ligation puncture models of sepsis, we observed elevated levels of leptin and soluble leptin receptor (sLR)...
  73. Riestra P, Garcia Anguita A, Torres Cantero A, Bayonas M, De Oya M, Garces C. Association of the Q223R polymorphism with age at menarche in the leptin receptor gene in humans. Biol Reprod. 2011;84:752-5 pubmed publisher
    ..Our aim was to analyze the relationship of the Q223R polymorphism in the leptin receptor gene (LEPR(Q223R)) with AAM in a population-based sample of healthy pubertal girls...
  74. Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ouedrani A, Ben Rejeb N, et al. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genet Test Mol Biomarkers. 2012;16:726-33 pubmed publisher
    ..studies tried to establish the relationship between obesity and the common polymorphisms of leptin (LEP) and leptin receptor (LEPR) genes, but results were controversial...
  75. Lakka T, Rankinen T, Weisnagel S, Chagnon Y, Lakka H, Ukkola O, et al. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes. 2004;53:1603-8 pubmed
    ..We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic whites (n =..
  76. Ross J, Oeffinger K, Davies S, Mertens A, Langer E, Kiffmeyer W, et al. Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2004;22:3558-62 pubmed
    ..Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might ..
  77. Muy Rivera M, Ning Y, Frederic I, Vadachkoria S, Luthy D, Williams M. Leptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk. Physiol Res. 2005;54:167-74 pubmed
    Few investigators have simultaneously evaluated leptin, soluble leptin receptor (SLR) and leptin gene polymorphisms in preeclampsia cases and controls. We examined these three biomolecular markers in 40 preeclampsia cases and 39 controls...
  78. Loos R, Rankinen T, Chagnon Y, Tremblay A, Perusse L, Bouchard C. Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study. Int J Obes (Lond). 2006;30:183-90 pubmed
    ..We examined the associations between polymorphisms in the LEP and leptin receptor (LEPR) genes and resting metabolic rate (RMR) and respiratory quotient (RQ) in the Quebec Family Study...
  79. Farooqi I, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh J, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med. 2007;356:237-47 pubmed
    ..Congenital leptin-receptor deficiency should be considered in the differential diagnosis in any child with hyperphagia and severe obesity in the absence of developmental delay or dysmorphism. ..
  80. Kamikubo Y, Dellas C, Loskutoff D, Quigley J, Ruggeri Z. Contribution of leptin receptor N-linked glycans to leptin binding. Biochem J. 2008;410:595-604 pubmed
    The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated...
  81. Kim S, Kim S, Lee J, Jee B, Ku S, Suh C, et al. Association of leptin receptor polymorphisms Lys109Arg and Gln223Arg with serum leptin profile and bone mineral density in Korean women. Am J Obstet Gynecol. 2008;198:421.e1-8 pubmed publisher
    ..The BMDs and serum levels of leptin, the soluble leptin receptor (sLR), and estradiol were measured, and the LEPR gene was genotyped...
  82. Ridker P, Pare G, Parker A, Zee R, Danik J, Buring J, et al. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet. 2008;82:1185-92 pubmed publisher
    ..2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself...
  83. Mizuta E, Kokubo Y, Yamanaka I, Miyamoto Y, Okayama A, Yoshimasa Y, et al. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens Res. 2008;31:1069-77 pubmed publisher
    ..investigated the associations among sweet preference, obesity, and polymorphisms of the leptin gene (LEP) or leptin receptor gene (LEPR)...
  84. Yapijakis C, Kechagiadakis M, Nkenke E, Serefoglou Z, Avgoustidis D, Vylliotis A, et al. Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. J Cancer Res Clin Oncol. 2009;135:603-12 pubmed publisher
    We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for ..
  85. Constantin A, Costache G, Sima A, Glavce C, Vladica M, Popov D. Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. Biochem Biophys Res Commun. 2010;391:282-6 pubmed publisher
    We aimed to investigate whether polymorphisms LEP G-2548A and LEPR Q223R in the human leptin (LEP), and leptin receptor (LEPR) genes are associated with obesity and metabolic traits in a sample of Romanian population...
  86. Wiedemann A, Vocke F, Fitzgerald J, Markert U, Jeschke U, Lohse P, et al. Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associated with hypertensive disorders in pregnancy. Am J Reprod Immunol. 2010;63:310-7 pubmed publisher
    ..Therefore, we investigated polymorphisms in the genes encoding leptin, the leptin receptor, and PPARgamma2 in patients with PIH...
  87. Ge H, Huang L, Pourbahrami T, Li C. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem. 2002;277:45898-903 pubmed
    ..Genetically obese rodents with mutations of leptin or leptin receptor develop morbid obesity and diabetes...
  88. Skibola C, Holly E, Forrest M, Hubbard A, Bracci P, Skibola D, et al. Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2004;13:779-86 pubmed
  89. Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res. 2004;10:4325-31 pubmed
    To evaluate leptin and leptin receptor (OB-R) expression in human breast cancer and determine whether it could be effective for the prevention and treatment of breast cancer...
  90. Séron K, Corset L, Vasseur F, Boutin P, Gomez Ambrosi J, Salvador J, et al. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochem Biophys Res Commun. 2006;348:1232-8 pubmed
    Animal studies have illustrated the importance of the expression in adipose tissue of the leptin receptor (OB-R), and of SOCS3 an inhibitor of the leptin signaling pathway, in body weight regulation...
  91. Koda M, Sulkowska M, Wincewicz A, Kanczuga Koda L, Musiatowicz B, Szymanska M, et al. Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. Ann N Y Acad Sci. 2007;1095:90-8 pubmed
    Recent studies suggested that Ob (Ob) and its receptor (ObR) could be involved in the pathogenesis of various human malignancies, among others in endometrial cancer...