leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human

Top Publications

  1. ncbi A general kinetic approach to investigation of active-site availability in macromolecular catalysts
    M Resmini
    Laboratory of Structural and Mechanistic Enzymology, Department of Molecular and Cellular Biology, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS
    Biochem J 346:117-25. 2000
  2. ncbi Oleoyl-estrone lowers the body weight of both ob/ob and db/db mice
    M M Grasa
    , Universitat de Barcelona, Spain
    Horm Metab Res 32:246-50. 2000
  3. ncbi Anomalous temperature-dependence of the specific interaction of concanavalin A with a multivalent ligand-dextran
    A Waseem
    Protein Research Laboratory, Department of Biochemistry, Faculty of Medicine, A M University, Aligarh 202001, India
    Biochim Biophys Acta 746:65-71. 1983
  4. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
  5. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
  6. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
  7. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  8. ncbi Crystal structure of the obese protein leptin-E100
    F Zhang
    Research Technologies and Proteins, Endocrine Research Divisions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 387:206-9. 1997
  9. ncbi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
  10. ncbi G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
    Tsu Nai Wang
    Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Obesity (Silver Spring) 14:183-7. 2006

Research Grants

  1. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2004
  2. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen M Gravallese; Fiscal Year: 2010
  3. Mechanobiology of 3D Trabecular Bone Explants
    X Guo; Fiscal Year: 2009
  4. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2010
  5. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
  6. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2010
  7. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
  8. C-reactive protein promotes myeloma cell-mediated bone destruction
    Qing Yi; Fiscal Year: 2010
  9. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2009
  10. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2007

Detail Information

Publications232 found, 100 shown here

  1. ncbi A general kinetic approach to investigation of active-site availability in macromolecular catalysts
    M Resmini
    Laboratory of Structural and Mechanistic Enzymology, Department of Molecular and Cellular Biology, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS
    Biochem J 346:117-25. 2000
    ..under catalytic conditions where substrate concentrations greatly exceed catalyst concentration with those (klim/obs, the limiting value of the first-order rate constant, k(obs), at saturating concentrations of catalyst; and Kapp/m) ..
  2. ncbi Oleoyl-estrone lowers the body weight of both ob/ob and db/db mice
    M M Grasa
    , Universitat de Barcelona, Spain
    Horm Metab Res 32:246-50. 2000
    ..The results suggest that oleoyl-estrone effects on body fat reserves and insulin resistance are not mediated by leptin, since ob/ob mice lack this hormone and in the db/db it is present but cannot induce effects because of defective ..
  3. ncbi Anomalous temperature-dependence of the specific interaction of concanavalin A with a multivalent ligand-dextran
    A Waseem
    Protein Research Laboratory, Department of Biochemistry, Faculty of Medicine, A M University, Aligarh 202001, India
    Biochim Biophys Acta 746:65-71. 1983
    ..0. Analysis of the turbidity data according to the first-order kinetic law yielded the rate constant, k(obs). At pH 7.4 the curve between In k(obs) and 1/T was biphasic in the temperature range 8...
  4. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
    ..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot...
  5. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
    The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure...
  6. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system...
  7. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  8. ncbi Crystal structure of the obese protein leptin-E100
    F Zhang
    Research Technologies and Proteins, Endocrine Research Divisions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 387:206-9. 1997
    ..The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest...
  9. ncbi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
    ..a genetic association study was performed on 126 patients with adolescent idiopathic scoliosis and 197 healthy controls from independent Hungarian pedigrees...
  10. ncbi G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
    Tsu Nai Wang
    Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Obesity (Silver Spring) 14:183-7. 2006
    We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity...
  11. ncbi The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    Jean L Chan
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1409-21. 2003
    To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state and three 72-hour fasting studies ..
  12. ncbi Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion
    Marco R Schroeter
    Department of Cardiology and Pulmonary Medicine, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Circ Res 103:536-44. 2008
    The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo...
  13. ncbi Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
    The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in ..
  14. ncbi Leptin regulates striatal regions and human eating behavior
    I Sadaf Farooqi
    University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Science 317:1355. 2007
    Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation...
  15. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  16. ncbi Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness
    B Gwen Windham
    Department of Internal Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 23:501-7. 2010
    ..adipocytes account for most adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness.
  17. ncbi Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    Grazia Ambrosini
    Department of Molecular Biology, Institute for Diabetes Discovery, 25 Business Park Drive, Branford, CT 06405, USA
    J Biol Chem 277:34601-9. 2002
    In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic cytokine with multiple physiological effector functions...
  18. ncbi Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy
    Kylie A McLachlan
    Department of Endocrinology, St Vincents Hospital, Victoria, Australia
    Diabetes Metab Res Rev 22:131-8. 2006
    The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear...
  19. ncbi Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
    ..b>Leptin, IL6 and adiponectin can be considered as adiposity signals...
  20. ncbi Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans
    Mary Yannakoulia
    Department of Nutrition Dietetics, Harokopio University, 17671 Athens, Greece
    J Clin Endocrinol Metab 88:1730-6. 2003
    The adipocyte-derived hormones leptin [which circulates in a free form and bound to a soluble leptin receptor (sOB-R)], adiponectin, and resistin play a key role in regulating energy homeostasis and metabolism...
  21. ncbi Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
    b>Leptin plays an important role in the regulation of body weight and is known to circulate in both free and bound forms. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin...
  22. ncbi Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain
    Olga Portoles
    Genetic and Molecular Epidemiology Unit Department of Preventive Medicine and Public Health School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Eur J Epidemiol 21:605-12. 2006
    ..In animal models, the leptin (LEP) and the leptin receptor (LEPR) genes have been shown to be very important in obesity because leptin ..
  23. ncbi The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients
    S Ben Ali
    Research Laboratory LAB SM 01, Biochemistry Department, Rabta Hospital, Tunis, Tunisia
    Blood Press 17:278-83. 2008
    To examine the association of a common -2548G/A (rs7799039) promoter variant of the human leptin gene (LEP) with obesity or body mass index (BMI) and its associated phenotypes such as blood pressure variability and the prevalence of ..
  24. ncbi Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents
    Jakub Cieslak
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60 637 Poznan, Poland
    Mol Biol Rep 38:1793-8. 2011
    ..In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) and a control group ..
  25. ncbi Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    Jean L Chan
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 51:2105-12. 2002
    b>Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological processes...
  26. ncbi Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
    Alexandra Grosfeld
    INSERM U 465, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:42953-7. 2002
    Increased placental leptin has been demonstrated in preeclampsia, a pregnancy disorder associated with placental hypoxia. This suggests that leptin gene expression is enhanced in response to oxygen deficiency in this organ...
  27. ncbi Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers
    Marialena Kyriakakou
    Neonatal and Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, 10682 Athens, Greece
    Eur J Endocrinol 158:343-8. 2008
    b>Leptin and adiponectin are two adipocytokines that play a critical role in the control of energy balance and metabolism as well as in conditions, such as insulin resistance, inflammation, and the development of the metabolic syndrome in ..
  28. ncbi Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways
    Bartolome Burguera
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Med Sci Monit 12:BR341-9. 2006
    Serum leptin levels are strongly and directly related to fat body mass (FBM). Bone mineral density (BMD) increases with FBM, and obesity has a protective effect against osteoporosis...
  29. ncbi Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line
    Stefania Catalano
    Centro Sanitario and the Department of PharmacoBiology, Faculty of Pharmacy, University of Calabria, 87030 Arcavacata di Rende, Italy
    J Biol Chem 278:28668-76. 2003
    b>Leptin, a product of adipocytes, is involved in the regulation of body weight and results strongly correlated to body fat content...
  30. ncbi Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy
    Mirko Riolfi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Brain Pathol 20:481-9. 2010
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  31. ncbi Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    Vanity McMurtry
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
    Clin Exp Metastasis 26:197-204. 2009
    In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion...
  32. ncbi Leptin induces endothelin-1 in endothelial cells in vitro
    Peter Quehenberger
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Circ Res 90:711-8. 2002
    b>Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure...
  33. ncbi Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome
    Mei Gen Li
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 31006, China
    J Clin Endocrinol Metab 92:4771-6. 2007
    ..was to evaluate whether polycystic ovarian syndrome (PCOS)-associated infertility is related to alterations of leptin, leptin receptor (Ob-R), and the phosphorylated signal transducer and activator of transcription 3 (p-STAT3)/..
  34. ncbi Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    Robert Wolk
    Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
    Atherosclerosis 183:131-9. 2005
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  35. ncbi Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002
    b>Leptin is synthesized in adipocytes and acts primarily through central pathways suppressing appetite and increasing the metabolic rate in rodents as well as in humans...
  36. ncbi Relation between first trimester maternal serum leptin levels and body mass index in normotensive and pre-eclamptic pregnancies--role of leptin as a marker of pre-eclampsia: a prospective case-control study
    Sofoklis Samolis
    Department of Obstetrics and Gynaecology Tzaneio General Hospital, Pireaus, Greece
    Gynecol Endocrinol 26:338-43. 2010
    We measured first trimester plasma leptin concentrations in 37 women who subsequently developed pre-eclampsia and 53 normotensive controls to determine the interrelation between leptin and body mass index (BMI) in both groups...
  37. ncbi Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor
    Mitsuru Shimamura
    Biomedical Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Biochem Biophys Res Commun 322:1080-5. 2004
    ..The current study examined the regulation of Angptl3 by leptin and insulin, both of which are key players in the metabolic syndrome...
  38. ncbi Leptin: a potential marker of placental insufficiency
    Jacques Lepercq
    Service de Gynecologie Obstetrique, Hopital Cochin Saint Vincent de Paul, Paris, France
    Gynecol Obstet Invest 55:151-5. 2003
    To investigate placental leptin production in placental insufficiency, placental leptin production was measured in women with severe preeclampsia (group 1) and in normotensive pregnancies associated with intrauterine growth restriction (..
  39. ncbi Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    Alexandra Nieters
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nutr 41:210-21. 2002
    ....
  40. ncbi Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults...
  41. ncbi G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass
    Edward Franek
    Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital, Ministry for Internal Affairs, Warsaw, Poland
    Pol Arch Med Wewn 120:175-80. 2010
    ..Clinical studies have shown either positive or in some other cases negative correlations between leptinemia and bone mineral density (BMD) or bone mineral content (BMC)...
  42. ncbi Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study
    M L Hart Sailors
    Department of Pediatrics, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Diabetes Obes Metab 9:548-57. 2007
    To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in ..
  43. ncbi Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin
    Ju Young Kim
    Laboratory of Hematopoiesis and Hematologic Malignancy, Cancer Research Institute, Seoul National University, College of Medicine, Seoul, Korea
    Oncol Rep 23:1369-74. 2010
    b>Leptin acts as a growth factor in normal cells as well as in various types of cancer cells. We investigated the effects of leptin on human acute myelogenous leukemia (AML) cells...
  44. ncbi DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  45. ncbi Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina
    Laxman Dubey
    Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology HUST, Wuhan 430030, Hubei, PR China
    Int J Cardiol 126:183-9. 2008
    ..By activating different immune/inflammatory cells or directly acting on the vessel wall leptin has been shown to play a potential role in the development of acute coronary syndrome...
  46. ncbi Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample
    Erik Ingelsson
    The Framingham Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    J Clin Endocrinol Metab 93:3149-57. 2008
    The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown.
  47. ncbi The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    E D Green
    Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 5:5-12. 1995
    ....
  48. ncbi A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure...
  49. ncbi Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis
    Yong Qiu
    Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Spine (Phila Pa 1976) 32:2703-10. 2007
    A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS).
  50. ncbi Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter
    Ingo Melzner
    Department of Pathology, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Biol Chem 277:45420-7. 2002
    The peptide hormone leptin plays a major role in the regulation of energy intake and expenditure and is predominantly expressed in mature adipocytes but not in preadipocytes...
  51. ncbi Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults
    Caroline T M van Rossum
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Obes Res 11:377-86. 2003
    To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain.
  52. ncbi Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates
    Shekman L Wong
    Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, California 91320, USA
    J Clin Endocrinol Metab 89:2672-7. 2004
    b>Leptin is an adipocyte-secreted hormone that regulates energy homeostasis and neuroendocrine function...
  53. ncbi Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 13:779-86. 2004
    ..Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and ..
  54. ncbi Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study
    S Soderberg
    International Diabetes Institute, Melbourne, Australia
    Int J Obes (Lond) 31:1126-33. 2007
    To determine if levels of the adipocyte-derived hormone, leptin, predict the development of type 2 diabetes.
  55. ncbi Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
    Stefania Catalano
    Centro Sanitario, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
    J Biol Chem 279:19908-15. 2004
    b>Leptin is a hormone with multiple biological actions, produced predominantly by adipose tissue. In humans, plasma levels correlate with total body fat, and high concentrations occur in obese women...
  56. ncbi Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation
    Chang Qing Zhao
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Spine (Phila Pa 1976) 33:E858-64. 2008
    ..Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Human Ethics Review Committee and Animal Care and Use Committee...
  57. ncbi Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis
    M C Park
    Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea
    Scand J Rheumatol 36:101-6. 2007
    To determine whether serum leptin levels are elevated in men with ankylosing spondylitis (AS) and whether the levels correlate with serum cytokine profiles and disease activity of AS.
  58. ncbi Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism
    T Simopoulou
    Department of Biology, University of Thessalia, Medical School, Larissa, Greece
    Osteoarthritis Cartilage 15:872-83. 2007
    To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA).
  59. ncbi Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    Makoto Ishikawa
    Department of Surgery, Division of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:4325-31. 2004
    To evaluate leptin and leptin receptor (OB-R) expression in human breast cancer and determine whether it could be effective for the prevention and treatment of breast cancer.
  60. ncbi Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1 alpha in human colorectal cancer
    M Koda
    Department of Pathomorphology, Medical University of Bialystok, Bialystok, Poland
    Ann Oncol 18:vi116-9. 2007
    The obesity hormone, leptin, has been found to play a role in development and proliferation of normal and malignant tissues...
  61. ncbi Contribution of leptin receptor N-linked glycans to leptin binding
    Yuichi Kamikubo
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 410:595-604. 2008
    The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated...
  62. ncbi Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease
    E Porreca
    Department of Medicine and Aging, and Aging Research Center, CeSI, GD Annunzio University Foundation, Chieti Pescara, Italy
    Int J Obes (Lond) 30:209-13. 2006
    ..No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease...
  63. ncbi Influence of nutritional recovery on the leptin axis in severely malnourished children
    Katja Stein
    Institute of Nutrition, Friedrich Schiller University, Dornburger Strasse 24, D 07743 Jena, Germany
    J Clin Endocrinol Metab 91:1021-6. 2006
    b>Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood.
  64. ncbi Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1
    Robert Ducroc
    Institut National de la Santé et de la Recherche Médicale Unité 410, IFR02 Claude Bernard, Faculte de Medecine Xavier Bichat, Paris, France
    Diabetes 54:348-54. 2005
    The effect of leptin on glucose transport was studied in rat jejunal mucosa in Ussing chambers. Leptin was added in the luminal or the serosal compartment before the tissues were challenged with 1, 10, or 50 mmol/l glucose...
  65. ncbi LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals
    Hamilton M Hinuy
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Sao Paulo University, Sao Paulo, SP, Brazil
    Mol Genet Metab 89:374-80. 2006
    b>Leptin plays an important role in satiety signaling and is related to obesity. Variants of leptin gene (LEP) have been associated to differences in plasma leptin levels and obesity-related phenotypes...
  66. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..SCD1 is suppressed by leptin but induced by insulin. We have used animal models to dissect the effects of these hormones on SCD1...
  67. ncbi Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome
    Erdinc Erturk
    Department of Endocrinology, Uludag University Hospital, Bursa, Turkey
    Fertil Steril 82:1364-8. 2004
    To examine serum leptin concentrations in obese and lean patients with polycystic ovary syndrome (PCOS) to assess whether the changes in leptin levels are due to obesity or hormonal alterations.
  68. ncbi Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha
    S Cascio
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Oncogene 27:540-7. 2008
    We reported previously that the obesity hormone leptin is overexpressed in breast cancer biopsies...
  69. ncbi Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    b>Leptin signaling may promote atherothrombosis and lead to cardiovascular disease. However, whether leptin is associated with human atherosclerosis, distinct from thrombosis, is unknown...
  70. ncbi Leptin and coronary heart disease risk: prospective case control study of British women
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Obesity (Silver Spring) 15:1694-701. 2007
    Prospective studies have shown a positive association between leptin concentrations and coronary heart disease (CHD) in men, but its effect in women is unclear...
  71. ncbi Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients
    Anna Kumor
    Department of Laboratory Diagnostics, Medical University, Lodz, Poland
    Int J Colorectal Dis 24:275-81. 2009
    b>Leptin, adiponectin, and resistin are the proteins secreted by adipocytes, which affects the metabolism. While the role of leptin in colon carcinogenesis is documented, the effect of adiponectin and resistin remains unclear...
  72. ncbi Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients
    Samir Ben Ali
    Biochemistry Department, Research Laboratory LR99ES11, Rabta Hospital, Tunis, Tunisia
    Clin Biochem 42:584-8. 2009
    The aim of this study was to examine the association of the G-2548A polymorphism of the human leptin gene (LEP) with body mass index (BMI), plasma leptin, insulin, and lipid parameters in a sample of Tunisian population.
  73. ncbi Human leptin locus (LEP) alleles and BMI in Samoans
    S T McGarvey
    International Health Institute, Brown Medical School, Providence, Rhode Island, USA
    Int J Obes Relat Metab Disord 26:783-8. 2002
    ....
  74. ncbi IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
    Diabetes 56:2705-9. 2007
    ..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures.
  75. ncbi Leptin regulation of the interleukin-1 system in human endometrial cells
    Ruben Rene Gonzalez
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Mol Hum Reprod 9:151-8. 2003
    We have previously shown that (i). leptin and leptin receptor (Ob-R) are expressed in the human endometrium, and (ii). leptin secretion is regulated in blastocyst and endometrial epithelial cell (EEC) co-cultures...
  76. ncbi A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls
    C Le Stunff
    Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, Rene Descartes University, Paris, France
    Diabetes 49:2196-200. 2000
    Mutations in the leptin gene lead to rare obese syndromes of Mendelian inheritance in humans and rodents. However, no relevant mutations are found in the coding region of leptin gene DNA in patients with common multifactorial obesity...
  77. ncbi A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin
    J Hoffstedt
    Department of Medicine at Huddinge University Hospital, Stockholm, Sweden
    Horm Metab Res 34:355-9. 2002
    There is a large inter-individual variation in circulating leptin concentrations at each level of body fat content. The reason for this is unknown...
  78. ncbi Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin
    Markus Laimer
    Department of Medicine, University of Innsbruck, Austria
    Obes Res 10:597-601. 2002
    Soluble leptin receptor (sOB-R) represents the main binding site for leptin in human blood...
  79. ncbi Genetic diversity and evolution of the human leptin locus tetranucleotide repeat
    Susan Moffett
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 110:412-7. 2002
    ..understand the evolutionary history of the gene region containing the multifunctional adipose tissue hormone leptin, we genotyped 1,957 individuals from 12 world populations for a highly variable tetranucleotide repeat ..
  80. ncbi Leptin, insulin-like growth factor (IGF)-I and IGF binding protein-3 levels in children with constitutional delay of growth
    A Bideci
    Department of Pediatric Endocrinology, Gazi University Faculty of Medicine, Ankara, Turkey
    J Pediatr Endocrinol Metab 15:41-6. 2002
    ..in order to investigate the role of insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3) and leptin, the product of the ob gene synthesized by fat tissue cells, in constitutional delay of growth and puberty (CDGP) ..
  81. ncbi Leptin mediates a proliferative response in human MCF7 breast cancer cells
    Marie Noelle Dieudonne
    Service de Biochimie et Biologie Moléculaire, Faculté de médecine Paris Ouest, Centre Hospitalier de Poissy, Université Descartes Paris V, 78303 Poissy Cedex, France
    Biochem Biophys Res Commun 293:622-8. 2002
    Obesity is a risk factor of breast cancers. As leptin, a hormone mainly secreted by white adipocytes, elicits proliferative effects in some cell types, we tested the hypothesis that leptin could influence human breast cancer MCF-7 cell ..
  82. ncbi Leptin gene polymorphism is associated with hypertension independent of obesity
    Maki Shintani
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 87:2909-12. 2002
    b>Leptin is an adipocyte-derived hormone that regulates food intake and energy expenditure. Recent functional studies have suggested a direct effect of leptin on blood pressure...
  83. ncbi Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression
    Monica Bullo
    Unitat de Nutricio Humana, Facultat de Medicina i Ciencies de la Salut de Reus, Universitat Rovira i Virgili, Reus, Spain
    Obes Res 11:525-31. 2003
    To explore the links between tumor necrosis factor alpha (TNFalpha) and leptin adipose tissue expression and low-grade systemic inflammation and to determine the relationship between inflammation and the degree of adiposity, the presence ..
  84. ncbi Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells
    Marianna Terrasi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 125:1038-44. 2009
    b>Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity-related stimuli...
  85. ncbi Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue
    H Masuzaki
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Diabetes 44:855-8. 1995
    ..This study is the first report of the elucidation of ob gene expression in human tissues, thereby leading to better understanding of the physiological and clinical implications of the ob gene...
  86. ncbi The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes
    Diamantis Konstantinidis
    Laboratory of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Cell Stress Chaperones 14:591-601. 2009
    b>Leptin, a 16-kDa cytokine produced mainly by the adipose tissue, is known to increase energy expenditure while at the same time lowering food intake by acting directly on the hypothalamus...
  87. ncbi Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:2838-43. 2003
    ..rhythms in healthy normal-weight men and to compare the 24-h profile of adiponectin fluctuations with those of leptin, leptin-binding protein (sOB-R), and cortisol...
  88. ncbi [Leptin to adiponectin ratio, as an index of insulin resistance and atherosclerosis development]
    Małgorzata Kieć-Klimczak
    Zakład Biochemii Kliniicznej, Collegium Medicum UJ Kraków
    Przegl Lek 65:844-9. 2008
    ..The adipose tissue is a place where many adipokines, mainly leptin and adiponectin, are produced and released...
  89. ncbi Genetic relationships of body composition, serum leptin, and age at puberty in gilts
    L A Kuehn
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 87:477-83. 2009
    b>Leptin produced by adipocytes acts through leptin receptors in the hypothalamus to control appetite and food intake and thus communicates information about degree of fatness...
  90. ncbi [Leptin promotes neointimal formation by stimulating vascular smooth muscle cell proliferation through leptin receptor]
    Yue chun Shen
    Department of Cardiology, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:634-8. 2009
    To evaluate the role of leptin in neointimal formation and related mechanisms.
  91. ncbi Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice
    Q Huang
    Centre de recherche sur le métabolisme énergétique CREME et Département d anatomie et de physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Neuroendocrinology 69:145-53. 1999
    The effect of leptin on the expression of melanin-concentrating hormone (MCH) was investigated in lean and genetically obese Lepob/Lepob mice. Murine leptin was subcutaneously infused using osmotic minipumps...
  92. ncbi [Plasma leptin levels in relation to body composition and body fat distribution in patients with Cushing's syndrome]
    Maciej Robaczyk
    Klinika Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii Pomorskiej AM w Szczecinie
    Pol Arch Med Wewn 110:1299-308. 2003
    It is known that body composition, especially body fat content, determines plasma leptin (LEP) levels...
  93. ncbi Plasma leptin, ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbreds
    Mary E Gordon
    Rutgers, The State University of New Jersey, Equine Science Center, Department of Animal Sciences, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Vet J 173:91-100. 2007
    ..plasma concentrations of glucose (GLU), insulin (INS), cortisol (CORT), ghrelin (GHRL), adiponectin (ADIP) and leptin (LEP) would be correlated with body composition and differ in fit (F) versus unfit (UF) horses...
  94. ncbi Acute nonspecific abdominal pain: A randomized, controlled trial comparing early laparoscopy versus clinical observation
    Mario Morino
    Chirurgia Generale II e Centro di Chirurgia Mini Invasiva Department of Surgery, University of Turin, Turin, Italy
    Ann Surg 244:881-6; discussion 886-8. 2006
    ..To evaluate, in a prospective, randomized, single-institution trial, the role of early laparoscopy in the management of nonspecific abdominal pain (NSAP) in young women...
  95. ncbi [Serum levels of leptin and several growth-related hormones in premature infants]
    Xiao yi Fang
    Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
    Zhonghua Er Ke Za Zhi 47:134-9. 2009
    b>Leptin (LEP) is mainly produced by white adipose tissue and participates in the energy metabolism and regulation of growth...
  96. ncbi Interactions of avian myeloblastosis virus nucleocapsid protein with nucleic acids
    C A Gelfand
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935
    J Biol Chem 268:18450-6. 1993
    ..Using salt back-titrations, the intrinsic equilibrium association constant per nucleic acid site, K(obs), was determined for NC binding to single- and double-stranded RNAs and DNAs. In 0.125 M NaCl, 40 mM HEPES at pH 7...
  97. ncbi Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice
    L Wang
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, 413 Zhaozhou Road, Shanghai, 200011, China
    Osteoporos Int 20:79-92. 2009
    ....
  98. ncbi Reaction of the Co(II)-substrate radical pair catalytic intermediate in coenzyme B12-dependent ethanolamine ammonia-lyase in frozen aqueous solution from 190 to 217 K
    Chen Zhu
    Department of Physics, Emory University, Atlanta, Georgia 30322, USA
    Biophys J 95:5890-900. 2008
    ..The observed first-order rate constants for the monoexponential (k(obs,m)) and the fast phase of the biexponential decay (k(obs,f)) adhere to the same linear relation on an lnk versus T(-..
  99. ncbi Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Epidemiol Biomarkers Prev 11:836-43. 2002
    ..Future studies should address the application of this intervention to additional transgenic mice as well as other MT models...
  100. ncbi Congenital esophageal stenosis associated with esophageal atresia: new concepts
    Ashraf H M Ibrahim
    Armed Forces Hospital, Southern Region, King Faisal Military City, P O Box 5062, Khamis Mushait, Kingdom of Saudi Arabia
    Pediatr Surg Int 23:533-7. 2007
    ..CES should be considered in the etiology of anastomotic stricture. Taking a surgical specimen routinely from the tip of the LEP during primary esophageal repair for histologic studies is highly recommended...
  101. ncbi Contributions of the histidine side chain and the N-terminal alpha-amino group to the binding thermodynamics of oligopeptides to nucleic acids as a function of pH
    Jeff D Ballin
    Department of Biochemistry and Molecular Biology and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biochemistry 49:2018-30. 2010
    ..For both HWKK and KWKK, equilibrium binding constants, K(obs), and magnitudes of log-log salt derivatives, SK(obs) identical with (partial differential logK(obs)/partial ..

Research Grants63

  1. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2004
    ..These experiments will validate IKKbeta as a major mediator of insulin resistance and as a useful target for the discovery of new drugs to treat type 2 diabetes and insulin resistance. ..
  2. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen M Gravallese; Fiscal Year: 2010
    ..However, data from our laboratory demonstrate a defect in the maturation of bone-forming osteoblasts (OBs) at sites of articular bone loss (erosions), with an accompanying inhibition in the formation of mineralized bone ..
  3. Mechanobiology of 3D Trabecular Bone Explants
    X Guo; Fiscal Year: 2009
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  4. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2010
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  5. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  6. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2010
    ..to support OC formation, increase SC production of osteoclastogenic cytokines, and promote SC differentiation into OBs through stimulation of CD40 signaling in SCs by T cell expressed CD40L...
  7. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  8. C-reactive protein promotes myeloma cell-mediated bone destruction
    Qing Yi; Fiscal Year: 2010
    ..project, we will focus on the ability of CRP to promote the generation of OCs and inhibit the generation of OBs in vitro;our studies will uncover a new mechanism by which bone destruction is caused by myeloma cells, and provide ..
  9. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2009
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  10. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2007
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  11. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  12. Mechanisms of Innate and Acquired Host Defense and Tissue Injury in Skin
    Delphine J Lee; Fiscal Year: 2010
    ..The investigation of these aspects of host defense mechanisms will yield new insights into the human immune system as well as provide novel targets for therapeutic intervention against a variety of infectious and skin diseases. ..
  13. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2010
    Maintenance of bone mass requires the integrated activity of osteoclasts (OCs) and osteoblasts (OBs)...
  14. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2006
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  15. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven Teitelbaum; Fiscal Year: 2009
    Maintenance of bone mass requires the integrated activity of osteoclasts (OCs) and osteoblasts (OBs)...
  16. GENETIC ANALYSIS OF MONOCYTE KILLING BY BACTERIA
    Howard Shuman; Fiscal Year: 2007
    ..v) Determine if the coiled:coil regions of the Lep proteins are required for translocation by the Icm/Dot system and/or for their function in host cells. ..
  17. Role of aTGF-beta Regulated Gene in human and mouse osteoblasts and skeleton
    Thomas Spelsberg; Fiscal Year: 2007
    ..During this laboratory's investigations of estrogen (E2) and TGFb actions on OBs, we discovered and characterized the novel TGFb Iducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  18. Role of a TGF-B Regulated Gene in Human and Mouse Osteoblasts and Skeleton
    Thomas C Spelsberg; Fiscal Year: 2010
    ..During this laboratory's investigations of E2 and TGFb actions in OBs, we discovered and characterized the novel TGFb Inducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  19. Computer Support for Pharmacy-Based Smoking Cessation
    FREDERICK BOCK; Fiscal Year: 2007
    ..from smokers to assess the extent of pharmacist counseling for smoking with no intervention (observation only: OBS). Pharmacists will then be trained in providing smoking cessation counseling...
  20. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2005
    ..system and tracer methods; (2) To collect real-time measurements of breath-by-breath alveolar concentrations (-700 obs.) and optimize a physiologically-based pharmacokinetic (PBPK) model for estimating of metabolism rates; (3) To ..
  21. Older Latina Women, Martial Status, and Cancer Screening
    Melanie Wasserman; Fiscal Year: 2007
    ..The focus for this study is on Latina women, because their use of preventive health services is particularly low. ..