leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human
Products:     leptin

Top Publications

  1. Tobi E, Lumey L, Talens R, Kremer D, Putter H, Stein A, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009;18:4046-53 pubmed publisher
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  2. Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, et al. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis. 2013;34:974-83 pubmed publisher
    b>Leptin overexpression is closely correlated with gastric cancer (GC) invasion, but its exact effect and the underlying mechanism in tumorigenesis remain poorly understood...
  3. Schinzari F, Tesauro M, Rovella V, Di Daniele N, Mores N, Veneziani A, et al. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. J Clin Endocrinol Metab. 2013;98:1235-41 pubmed publisher
    b>Leptin has nitric oxide (NO)-dependent vasodilator actions, but hyperleptinemia is an independent risk factor for cardiovascular disease...
  4. Allison M, Ix J, Morgan C, McClelland R, Rifkin D, Shimbo D, et al. Higher leptin is associated with hypertension: the Multi-Ethnic Study of Atherosclerosis. J Hum Hypertens. 2013;27:617-22 pubmed publisher
    ..enrolled in the Multi-Ethnic Study of Atherosclerosis, we examined associations between blood pressure and leptin, tumor necrosis factor-? (TNF?), resistin and total adiponectin. The mean age and body mass index (BMI) was 64...
  5. Gonzalez M, Lind L, Soderberg S. Leptin and endothelial function in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis. 2013;228:485-90 pubmed publisher
    b>Leptin levels are elevated in obese humans...
  6. Savino F, Liguori S, Benetti S, Sorrenti M, Fissore M, Cordero Di Montezemolo L. High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants. Acta Paediatr. 2013;102:e455-9 pubmed publisher
    To investigate serum leptin levels in breast-fed and formula-fed infants in infancy and their possible relationship to body mass index (BMI) in childhood...
  7. Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
    b>Leptin signaling has received considerable attention in the Alzheimer disease (AD) field...
  8. Zhou X, Chai Y, Chen K, Yang Y, Liu Z. A meta-analysis of reference values of leptin concentration in healthy postmenopausal women. PLoS ONE. 2013;8:e72734 pubmed publisher
    There are numerous reports about the leptin concentration (LC) in postmenopausal women (PW). Changes in LC can elicit different clinical outcomes. We systematically analyzed the LC in PW...
  9. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...

More Information

Publications190 found, 100 shown here

  1. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat ..
  2. Chen X, Shi J, Yang P, Wu Z. Preoperative plasma leptin levels predict delirium in elderly patients after hip fracture surgery. Peptides. 2014;57:31-5 pubmed publisher
    b>Leptin is considered to be a modulator of the immune response. Hypoleptinemia increases the risk for Alzheimer's disease and vascular dementia...
  3. Park H, Kwon H, Lim H, Hong B, Lee J, Park B, et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med. 2001;33:95-102 pubmed
    b>Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass...
  4. Yannakoulia M, Yiannakouris N, Bluher S, Matalas A, Klimis Zacas D, Mantzoros C. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab. 2003;88:1730-6 pubmed
    The adipocyte-derived hormones leptin [which circulates in a free form and bound to a soluble leptin receptor (sOB-R)], adiponectin, and resistin play a key role in regulating energy homeostasis and metabolism...
  5. Ishikawa M, Kitayama J, Nagawa H. Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer. World J Gastroenterol. 2006;12:5517-22 pubmed
    To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia...
  6. Moore S, Leitzmann M, Albanes D, Weinstein S, Snyder K, Virtamo J, et al. Adipokine genes and prostate cancer risk. Int J Cancer. 2009;124:869-76 pubmed publisher
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis.
  7. Mutabaruka M, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res Ther. 2010;12:R20 pubmed publisher
    b>Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation...
  8. Ferla R, Bonomi M, Otvos L, Surmacz E. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer. 2011;11:303 pubmed publisher
    b>Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies, including brain tumors...
  9. Bideci A, Cinaz P, Hasanoglu A, Tumer L. Leptin, insulin-like growth factor (IGF)-I and IGF binding protein-3 levels in children with constitutional delay of growth. J Pediatr Endocrinol Metab. 2002;15:41-6 pubmed
    ..in order to investigate the role of insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3) and leptin, the product of the ob gene synthesized by fat tissue cells, in constitutional delay of growth and puberty (CDGP) ..
  10. Sundell J, Huupponen R, Raitakari O, Nuutila P, Knuuti J. High serum leptin is associated with attenuated coronary vasoreactivity. Obes Res. 2003;11:776-82 pubmed
    Hyperleptinemia, a hallmark of obesity, appears to be a risk factor for coronary artery disease. However, although leptin is a vasoactive hormone, no studies addressing leptin's effect on coronary perfusion have been performed...
  11. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga Koda L, Golaszewska J, et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res. 2006;12:1447-53 pubmed
    Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival...
  12. Kim K, Shin A, Lee Y, Kim S, Kim Y, Lee E. Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women. Hum Reprod. 2012;27:2193-200 pubmed publisher
    ..Ten single nucleotide polymorphisms (SNPs) in the leptin (LEP), leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma (PPAR?) genes were investigated ..
  13. Kloiber S, Ripke S, Kohli M, Reppermund S, Salyakina D, Uher R, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. Eur Neuropsychopharmacol. 2013;23:653-62 pubmed publisher
    b>Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and ..
  14. Mann D, Johnson A, Gimpel T, Castracane V. Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J Clin Endocrinol Metab. 2003;88:3339-45 pubmed
    We determined developmental changes in circulating levels of the soluble leptin receptor (sOB-R), leptin, and gonadal hormones in human subjects...
  15. Gruber H, Ingram J, Hoelscher G, Hanley E. Leptin expression by annulus cells in the human intervertebral disc. Spine J. 2007;7:437-43 pubmed
    It is now known that leptin acts not only as a metabolic signal related to energy homeostasis but also as an endocrine hormone regulating traditional endocrine systems and neuroendocrine function in various cells...
  16. Hogg K, Blair J, von Dadelszen P, Robinson W. Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia. Mol Cell Endocrinol. 2013;367:64-73 pubmed publisher
    In pre-eclampsia, placental leptin is up-regulated and leptin is elevated in maternal plasma...
  17. Ben Ali S, Kallel A, Ftouhi B, Sediri Y, Feki M, Slimane H, et al. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin Biochem. 2009;42:584-8 pubmed publisher
    The aim of this study was to examine the association of the G-2548A polymorphism of the human leptin gene (LEP) with body mass index (BMI), plasma leptin, insulin, and lipid parameters in a sample of Tunisian population...
  18. Gong D, Bi S, Pratley R, Weintraub B. Genomic structure and promoter analysis of the human obese gene. J Biol Chem. 1996;271:3971-4 pubmed
    ..A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report. ..
  19. Porreca E, Di Febbo C, Pintor S, Baccante G, Gatta V, Moretta V, et al. Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. Int J Obes (Lond). 2006;30:209-13 pubmed
    ..Moreover, no differences were observed in the plasma leptin concentrations between cases and control subjects (22 +/- 19 vs 22 +/- 14 ng/ml, P = 0...
  20. Kim J, Park H, Yoon J, Kim S, Kim E, Song S, et al. Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin. Oncol Rep. 2010;23:1369-74 pubmed
    b>Leptin acts as a growth factor in normal cells as well as in various types of cancer cells. We investigated the effects of leptin on human acute myelogenous leukemia (AML) cells...
  21. Wang M, Helzlsouer K, Smith M, Hoffman Bolton J, Clipp S, Grinberg V, et al. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate. 2009;69:874-85 pubmed publisher
    ..Although none of the SNPs in the obesity genes tested was associated, this does not rule out a complex role of obesity and its metabolic consequences in prostate cancer etiology. ..
  22. Dalamaga M, Srinivas S, Elovitz M, Chamberland J, Mantzoros C. Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study. Metabolism. 2011;60:1539-44 pubmed publisher
    ..tissue-secreted hormones adiponectin, which has immune-modulating, metabolic, and angiogenic properties, and leptin, which reflects overall fat mass, are associated with PE risk...
  23. Asferg C, Møgelvang R, Flyvbjerg A, Frystyk J, Jensen J, Marott J, et al. Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens. 2010;23:327-33 pubmed publisher
    b>Leptin and adiponectin are hormones secreted by adipose tissue, and both hormones are candidate intermediaries between adipose tissue and overweight-related diseases...
  24. Brandl E, Frydrychowicz C, Tiwari A, Lett T, Kitzrow W, Buttner S, et al. Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38:134-41 pubmed publisher
    ..Previous studies have indicated an impact of genetic variation in the genes encoding leptin, LEP, and leptin receptor, LEPR, on AIWG, but results have not been conclusive...
  25. Kyriakakou M, Malamitsi Puchner A, Militsi H, Boutsikou T, Margeli A, Hassiakos D, et al. Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers. Eur J Endocrinol. 2008;158:343-8 pubmed publisher
    b>Leptin and adiponectin are two adipocytokines that play a critical role in the control of energy balance and metabolism as well as in conditions, such as insulin resistance, inflammation, and the development of the metabolic syndrome in ..
  26. Delporte M, El Mkadem S, Quisquater M, Brichard S. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. Am J Physiol Endocrinol Metab. 2004;287:E446-53 pubmed
    Adiponectin (ApN) and leptin are two adipocytokines that control fuel homeostasis, body weight, and insulin sensitivity. Their interplay is still poorly studied...
  27. Saxena N, Vertino P, Anania F, Sharma D. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem. 2007;282:13316-25 pubmed
    ..b>Leptin, the key player in the regulation of energy balance and body weight control also acts as a growth factor on ..
  28. Doecke J, Zhao Z, Stark M, Green A, Hayward N, Montgomery G, et al. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol Biomarkers Prev. 2008;17:1007-12 pubmed publisher
    ..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis. ..
  29. Riestra P, Garcia Anguita A, Viturro E, Schoppen S, de Oya M, Garces C. Influence of the leptin G-2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents. Ann Hum Genet. 2010;74:335-9 pubmed publisher
    Polymorphisms in the leptin gene (LEP) have been associated with leptin levels and obesity in some studies in adults though this link has scarcely been investigated in children...
  30. Al Shoumer K, Al Asousi A, Doi S, Vasanthy B. Serum leptin and its relationship with metabolic variables in Arabs with type 2 diabetes mellitus. Ann Saudi Med. 2008;28:367-70 pubmed
    Most studies on serum leptin in type 2 diabetes mellitus have focused on white populations...
  31. Uddin S, Bavi P, Siraj A, Ahmed M, Al Rasheed M, Hussain A, et al. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. Endocr Relat Cancer. 2010;17:191-202 pubmed publisher
    The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary human malignancies has been reported; however, their role in papillary thyroid cancer (PTC) has not yet been evaluated...
  32. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398-401 pubmed
    The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure...
  33. Dieudonne M, Machinal Quelin F, Serazin Leroy V, Leneveu M, Pecquery R, Giudicelli Y. Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem Biophys Res Commun. 2002;293:622-8 pubmed
    Obesity is a risk factor of breast cancers. As leptin, a hormone mainly secreted by white adipocytes, elicits proliferative effects in some cell types, we tested the hypothesis that leptin could influence human breast cancer MCF-7 cell ..
  34. van Rossum C, Hoebee B, van Baak M, Mars M, Saris W, Seidell J. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res. 2003;11:377-86 pubmed
    To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain...
  35. Gavrila A, Peng C, Chan J, Mietus J, Goldberger A, Mantzoros C. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab. 2003;88:2838-43 pubmed
    ..rhythms in healthy normal-weight men and to compare the 24-h profile of adiponectin fluctuations with those of leptin, leptin-binding protein (sOB-R), and cortisol...
  36. Portoles O, Sorlí J, Frances F, Coltell O, Gonzalez J, Saiz C, et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol. 2006;21:605-12 pubmed
    ..In animal models, the leptin (LEP) and the leptin receptor (LEPR) genes have been shown to be very important in obesity because leptin ..
  37. Bruun J, Pedersen S, Kristensen K, Richelsen B. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol. 2002;190:91-9 pubmed
    b>Leptin is synthesized in adipocytes and acts primarily through central pathways suppressing appetite and increasing the metabolic rate in rodents as well as in humans...
  38. Shimamura M, Matsuda M, Ando Y, Koishi R, Yasumo H, Furukawa H, et al. Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. Biochem Biophys Res Commun. 2004;322:1080-5 pubmed
    ..The current study examined the regulation of Angptl3 by leptin and insulin, both of which are key players in the metabolic syndrome...
  39. Pai R, Lin C, Tran T, Tarnawski A. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. Biochem Biophys Res Commun. 2005;331:984-92 pubmed
    Although leptin is known to induce proliferative response in gastric cancer cells, the mechanism(s) underlying this action remains poorly understood...
  40. Abdullah S, Khera A, Leonard D, Das S, Canham R, Kamath S, et al. Sex differences in the association between leptin and CRP: results from the Dallas Heart Study. Atherosclerosis. 2007;195:404-10 pubmed
    ..We evaluated how the adipokine leptin influenced these relationships...
  41. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, et al. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes. 1995;44:855-8 pubmed
    ..This study is the first report of the elucidation of ob gene expression in human tissues, thereby leading to better understanding of the physiological and clinical implications of the ob gene. ..
  42. Skibola C, Holly E, Forrest M, Hubbard A, Bracci P, Skibola D, et al. Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2004;13:779-86 pubmed
    ..Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and ..
  43. Ben Ali S, Kallel A, Ftouhi B, Sediri Y, Feki M, Slimane H, et al. The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients. Blood Press. 2008;17:278-83 pubmed publisher
    To examine the association of a common -2548G/A (rs7799039) promoter variant of the human leptin gene (LEP) with obesity or body mass index (BMI) and its associated phenotypes such as blood pressure variability and the prevalence of ..
  44. Kumor A, Daniel P, Pietruczuk M, Małecka Panas E. Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis. 2009;24:275-81 pubmed publisher
    b>Leptin, adiponectin, and resistin are the proteins secreted by adipocytes, which affects the metabolism. While the role of leptin in colon carcinogenesis is documented, the effect of adiponectin and resistin remains unclear...
  45. Hoffstedt J, Eriksson P, Mottagui Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res. 2002;34:355-9 pubmed
    There is a large inter-individual variation in circulating leptin concentrations at each level of body fat content. The reason for this is unknown...
  46. Seven A, Guzel S, Aslan M, Hamuryudan V. Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis. Rheumatol Int. 2009;29:743-7 pubmed publisher
    This study was designed to investigate the serum and synovial fluid leptin levels, and inflammatory markers in rheumatoid arthritis (RA) patients. Serum and synovial fluid leptin levels were significantly higher (P > 0...
  47. Laimer M, Ebenbichler C, Kaser S, Sandhofer A, Weiss H, Nehoda H, et al. Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. Obes Res. 2002;10:597-601 pubmed
    Soluble leptin receptor (sOB-R) represents the main binding site for leptin in human blood...
  48. Otero M, Lago R, Lago F, Reino J, Gualillo O. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther. 2005;7:R581-91 pubmed
    The objective of the present study was to investigate the effect of leptin, alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse chondrogenic ATDC5 cell ..
  49. Hinuy H, Hirata M, Sampaio M, Armaganijan D, Salazar L, Hirata R. LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals. Mol Genet Metab. 2006;89:374-80 pubmed
    b>Leptin plays an important role in satiety signaling and is related to obesity. Variants of leptin gene (LEP) have been associated to differences in plasma leptin levels and obesity-related phenotypes...
  50. Shpilman M, Niv Spector L, Katz M, Varol C, Solomon G, Ayalon Soffer M, et al. Development and characterization of high affinity leptins and leptin antagonists. J Biol Chem. 2011;286:4429-42 pubmed publisher
    b>Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in a variety of biological processes, including energy metabolism, reproduction, and modulation of the immune response...
  51. Moreno L, Pineda I, Rodriguez G, Fleta J, Giner A, Juste M, et al. Leptin and metabolic syndrome in obese and non-obese children. Horm Metab Res. 2002;34:394-9 pubmed
    ..The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity...
  52. Le Stunff C, Le Bihan C, Schork N, Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes. 2000;49:2196-200 pubmed
    Mutations in the leptin gene lead to rare obese syndromes of Mendelian inheritance in humans and rodents. However, no relevant mutations are found in the coding region of leptin gene DNA in patients with common multifactorial obesity...
  53. Wang T, Huang M, Chang W, Ko A, Tsai E, Liu C, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14:183-7 pubmed
    We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity...
  54. Singh P, Hoffmann M, Wolk R, Shamsuzzaman A, Somers V. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:e302-7 pubmed
    There is increasing evidence of an association between leptin and increased cardiovascular risk...
  55. Lee S, Jo H, Kim M, You Y, Kim J. Association between metabolic syndrome and serum leptin levels in postmenopausal women. J Obstet Gynaecol. 2012;32:73-7 pubmed publisher
    ..b>Leptin is synthesised and secreted by adipocytes. Serum leptin levels are highly correlated with fat mass...
  56. Zhang Y, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, et al. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis. 2007;191:121-7 pubmed
    Cellular and animal studies suggest that leptin has proinflammatory and prothrombotic effects that could link increased adipose mass directly to atherogenesis...
  57. Pérez Pérez A, Gambino Y, Maymó J, Goberna R, Fabiani F, Varone C, et al. MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. Biochem Biophys Res Commun. 2010;396:956-60 pubmed publisher
    b>Leptin, the LEP gene product, is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy...
  58. Partida Pérez M, de la Luz Ayala Madrigal M, Peregrina Sandoval J, Macías Gómez N, Moreno Ortiz J, Leal Ugarte E, et al. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark. 2010;7:117-21 pubmed publisher
    b>Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it...
  59. Ambrosini G, Nath A, Sierra Honigmann M, Flores Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem. 2002;277:34601-9 pubmed
    In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic cytokine with multiple physiological effector functions...
  60. Rene Gonzalez R, Watters A, Xu Y, Singh U, Mann D, Rueda B, et al. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 2009;11:R36 pubmed publisher
    We have shown previously that treatment with pegylated leptin peptide receptor antagonist 2 (PEG-LPrA2) reduced the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor type 2 (VEGFR2) and ..
  61. Fischer Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth T, et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab. 2010;95:2836-40 pubmed publisher
    b>Leptin, a protein product of adipocytes, plays a critical role in the regulation of body weight, immune function, pubertal development, and fertility...
  62. Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS pat. J Autoimmun. 2004;23:169-77 pubmed
    b>Leptin is synthesized by adipocytes to regulate appetite. Leptin has also been implicated in the pathogenesis of multiple sclerosis (MS) leading to speculation about a beneficial effect of fasting to autoimmune patients...
  63. Park M, Lee S, Choi S, Park Y, Lee S. Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis. Scand J Rheumatol. 2007;36:101-6 pubmed
    To determine whether serum leptin levels are elevated in men with ankylosing spondylitis (AS) and whether the levels correlate with serum cytokine profiles and disease activity of AS...
  64. Melzner I, Scott V, Dorsch K, Fischer P, Wabitsch M, Brüderlein S, et al. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem. 2002;277:45420-7 pubmed
    The peptide hormone leptin plays a major role in the regulation of energy intake and expenditure and is predominantly expressed in mature adipocytes but not in preadipocytes...
  65. Aquila S, Gentile M, Middea E, Catalano S, Morelli C, Pezzi V, et al. Leptin secretion by human ejaculated spermatozoa. J Clin Endocrinol Metab. 2005;90:4753-61 pubmed
    b>Leptin action is a dynamic area of investigation that continues to broaden beyond the basic lipostatic model originally envisaged. Here, we show that leptin is expressed in and secreted from human ejaculated spermatozoa...
  66. Yeh W, Lu D, Lee M, Fu W. Leptin induces migration and invasion of glioma cells through MMP-13 production. Glia. 2009;57:454-64 pubmed publisher
    b>Leptin, the product of the obese gene, plays an important role in the regulation of body weight by coordinating metabolism, feeding behavior, energy balance, and neuroendocrine responses...
  67. Zhang F, Basinski M, Beals J, Briggs S, Churgay L, Clawson D, et al. Crystal structure of the obese protein leptin-E100. Nature. 1997;387:206-9 pubmed
    ..The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest...
  68. Holden K, Lindquist K, Tylavsky F, Rosano C, Harris T, Yaffe K. Serum leptin level and cognition in the elderly: Findings from the Health ABC Study. Neurobiol Aging. 2009;30:1483-9 pubmed publisher
    b>Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate production and clearance of amyloid beta (Abeta) in rodent models...
  69. Pechlivanis S, Bermejo J, Pardini B, Naccarati A, Vodickova L, Novotny J, et al. Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol. 2009;160:933-40 pubmed publisher
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
  70. Maymó J, Pérez Pérez A, Dueñas J, Calvo J, Sanchez Margalet V, Varone C. Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways. Endocrinology. 2010;151:3738-51 pubmed publisher
    b>Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor...
  71. Liao Y, Liang K, Lee W, Lee W, Lee I, Wang J, et al. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. Biomarkers. 2013;18:44-50 pubmed publisher
    ..Adipokines were measured by ELISA tests. The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0...
  72. Chehab F, Lim M, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996;12:318-20 pubmed
    ..We show here that repeated administration of only the recombinant human ob protein, leptin, into homozygous female ob/ob mice can correct their sterility, thus resulting in ovulation, pregnancy and ..
  73. Chen H, Charlat O, Tartaglia L, Woolf E, Weng X, Ellis S, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84:491-5 pubmed
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  74. Bullo M, García Lorda P, Megias I, Salas Salvado J. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res. 2003;11:525-31 pubmed
    To explore the links between tumor necrosis factor alpha (TNFalpha) and leptin adipose tissue expression and low-grade systemic inflammation and to determine the relationship between inflammation and the degree of adiposity, the presence ..
  75. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, et al. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Hum Genet. 2010;127:287-94 pubmed publisher
    ..This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor ..
  76. Hinuy H, Hirata M, Sampaio M, Armaganijan D, Arazi S, Salazar L, et al. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arq Bras Endocrinol Metabol. 2010;54:282-8 pubmed
    The relationship between variants of the leptin gene (LEP) and obesity and metabolic biomarkers was investigated in Brazilian individuals...
  77. Chen K, Li F, Li J, Cai H, Strom S, Bisello A, et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med. 2006;12:425-32 pubmed
    The mechanisms underlying leptin resistance are still being defined...
  78. Schroeter M, Leifheit M, Sudholt P, Heida N, Dellas C, Rohm I, et al. Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. Circ Res. 2008;103:536-44 pubmed publisher
    The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo...
  79. Geber S, Brandão A, Sampaio M. Effects of estradiol and FSH on leptin levels in women with suppressed pituitary. Reprod Biol Endocrinol. 2012;10:45 pubmed publisher
    ..b>Leptin regulates body weight and energy homeostasis...
  80. Welsh P, Murray H, Buckley B, de Craen A, Ford I, Jukema J, et al. Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. Diabetes Care. 2009;32:308-10 pubmed publisher
    To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women...
  81. Uddin S, Bavi P, Hussain A, Alsbeih G, Al Sanea N, AbdulJabbar A, et al. Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication. Carcinogenesis. 2009;30:1832-40 pubmed publisher
    We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol 3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in vitro studies using a panel of CRC cell lines...
  82. McGaffin K, Moravec C, McTiernan C. Leptin signaling in the failing and mechanically unloaded human heart. Circ Heart Fail. 2009;2:676-83 pubmed publisher
    Increased circulating leptin is present in human heart failure, and leptin deficiency is linked to worse outcomes in chronic ischemic injury...
  83. Chen X, Zha X, Chen W, Zhu T, Qiu J, Røe O, et al. Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer. Biomed Pharmacother. 2013;67:22-30 pubmed publisher
    b>Leptin is a circulating peptide hormone, encoded by the obesity (ob) gene, acting as a regulator of food intake via hypothalamic-mediated effects...
  84. Barba G, Russo O, Siani A, Iacone R, Farinaro E, Gerardi M, et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obes Res. 2003;11:160-6 pubmed
    The role of leptin in the association between body mass, central adiposity, and blood pressure (BP) is controversial...
  85. Chan J, Bullen J, Lee J, Yiannakouris N, Mantzoros C. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. J Clin Endocrinol Metab. 2004;89:335-43 pubmed
    Ghrelin, a stomach-derived orexigenic peptide, and leptin, a fat-derived anorexigenic hormone, act primarily in the hypothalamus to regulate energy homeostasis and have been reported to be regulated in opposite directions by acute and ..
  86. Maccio A, Madeddu C, Gramignano G, Mulas C, Floris C, Massa D, et al. Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications. J Mol Med (Berl). 2010;88:677-86 pubmed publisher
    ..Adipokines, in particular leptin, are at the center of the etiopathogenetic mechanisms by which obesity and related metabolic disorders influence ..
  87. Barrenetxe J, Villaro A, Guembe L, Pascual I, Munoz Navas M, Barber A, et al. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. Gut. 2002;50:797-802 pubmed
    b>Leptin, a hormone mainly produced by fat cells, acts primarily on the hypothalamus regulating energy expenditure and food intake...
  88. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia. 2007;39:22-7 pubmed
    The aim of our study was to investigate the relationships between the expression of leptin, leptin receptor in the testis and spermatogenesis, and testosterone (T) concentration in infertile men...
  89. Silha J, Krsek M, Skrha J, Sucharda P, Nyomba B, Murphy L. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003;149:331-5 pubmed
    Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin...
  90. Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18:1354-62 pubmed
    Soluble leptin receptor (SLR) represents the major leptin binding activity in plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding of membrane-spanning receptors...
  91. Giordano C, Vizza D, Panza S, Barone I, Bonofiglio D, Lanzino M, et al. Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells. Mol Oncol. 2013;7:379-91 pubmed publisher
    ..confers risks to breast cancer development and progression, and several reports indicate that the adipokine leptin, whose synthesis and plasma levels increase with obesity, might play an important role in modulating breast cancer ..