leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human
Products:     leptin

Top Publications

  1. Tobi E, Lumey L, Talens R, Kremer D, Putter H, Stein A, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009;18:4046-53 pubmed publisher
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  2. Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, et al. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis. 2013;34:974-83 pubmed publisher
    b>Leptin overexpression is closely correlated with gastric cancer (GC) invasion, but its exact effect and the underlying mechanism in tumorigenesis remain poorly understood...
  3. Schinzari F, Tesauro M, Rovella V, Di Daniele N, Mores N, Veneziani A, et al. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. J Clin Endocrinol Metab. 2013;98:1235-41 pubmed publisher
    b>Leptin has nitric oxide (NO)-dependent vasodilator actions, but hyperleptinemia is an independent risk factor for cardiovascular disease...
  4. Allison M, Ix J, Morgan C, McClelland R, Rifkin D, Shimbo D, et al. Higher leptin is associated with hypertension: the Multi-Ethnic Study of Atherosclerosis. J Hum Hypertens. 2013;27:617-22 pubmed publisher
    ..enrolled in the Multi-Ethnic Study of Atherosclerosis, we examined associations between blood pressure and leptin, tumor necrosis factor-? (TNF?), resistin and total adiponectin. The mean age and body mass index (BMI) was 64...
  5. Gonzalez M, Lind L, Soderberg S. Leptin and endothelial function in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis. 2013;228:485-90 pubmed publisher
    b>Leptin levels are elevated in obese humans...
  6. Savino F, Liguori S, Benetti S, Sorrenti M, Fissore M, Cordero Di Montezemolo L. High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants. Acta Paediatr. 2013;102:e455-9 pubmed publisher
    To investigate serum leptin levels in breast-fed and formula-fed infants in infancy and their possible relationship to body mass index (BMI) in childhood...
  7. Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
    b>Leptin signaling has received considerable attention in the Alzheimer disease (AD) field...
  8. Zhou X, Chai Y, Chen K, Yang Y, Liu Z. A meta-analysis of reference values of leptin concentration in healthy postmenopausal women. PLoS ONE. 2013;8:e72734 pubmed publisher
    There are numerous reports about the leptin concentration (LC) in postmenopausal women (PW). Changes in LC can elicit different clinical outcomes. We systematically analyzed the LC in PW...
  9. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...

More Information

Publications140 found, 100 shown here

  1. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat ..
  2. Chen X, Shi J, Yang P, Wu Z. Preoperative plasma leptin levels predict delirium in elderly patients after hip fracture surgery. Peptides. 2014;57:31-5 pubmed publisher
    b>Leptin is considered to be a modulator of the immune response. Hypoleptinemia increases the risk for Alzheimer's disease and vascular dementia...
  3. Wang T, Huang M, Chang W, Ko A, Tsai E, Liu C, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14:183-7 pubmed
    We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity...
  4. Singh P, Hoffmann M, Wolk R, Shamsuzzaman A, Somers V. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:e302-7 pubmed
    There is increasing evidence of an association between leptin and increased cardiovascular risk...
  5. Zhang Y, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, et al. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis. 2007;191:121-7 pubmed
    Cellular and animal studies suggest that leptin has proinflammatory and prothrombotic effects that could link increased adipose mass directly to atherogenesis...
  6. Pérez Pérez A, Gambino Y, Maymó J, Goberna R, Fabiani F, Varone C, et al. MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. Biochem Biophys Res Commun. 2010;396:956-60 pubmed publisher
    b>Leptin, the LEP gene product, is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy...
  7. Partida Pérez M, de la Luz Ayala Madrigal M, Peregrina Sandoval J, Macías Gómez N, Moreno Ortiz J, Leal Ugarte E, et al. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark. 2010;7:117-21 pubmed publisher
    b>Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it...
  8. Ambrosini G, Nath A, Sierra Honigmann M, Flores Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem. 2002;277:34601-9 pubmed
    In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic cytokine with multiple physiological effector functions...
  9. Rene Gonzalez R, Watters A, Xu Y, Singh U, Mann D, Rueda B, et al. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 2009;11:R36 pubmed publisher
    We have shown previously that treatment with pegylated leptin peptide receptor antagonist 2 (PEG-LPrA2) reduced the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor type 2 (VEGFR2) and ..
  10. Fischer Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth T, et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab. 2010;95:2836-40 pubmed publisher
    b>Leptin, a protein product of adipocytes, plays a critical role in the regulation of body weight, immune function, pubertal development, and fertility...
  11. Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS pat. J Autoimmun. 2004;23:169-77 pubmed
    b>Leptin is synthesized by adipocytes to regulate appetite. Leptin has also been implicated in the pathogenesis of multiple sclerosis (MS) leading to speculation about a beneficial effect of fasting to autoimmune patients...
  12. Yeh W, Lu D, Lee M, Fu W. Leptin induces migration and invasion of glioma cells through MMP-13 production. Glia. 2009;57:454-64 pubmed publisher
    b>Leptin, the product of the obese gene, plays an important role in the regulation of body weight by coordinating metabolism, feeding behavior, energy balance, and neuroendocrine responses...
  13. Holden K, Lindquist K, Tylavsky F, Rosano C, Harris T, Yaffe K. Serum leptin level and cognition in the elderly: Findings from the Health ABC Study. Neurobiol Aging. 2009;30:1483-9 pubmed publisher
    b>Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate production and clearance of amyloid beta (Abeta) in rodent models...
  14. Pechlivanis S, Bermejo J, Pardini B, Naccarati A, Vodickova L, Novotny J, et al. Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol. 2009;160:933-40 pubmed publisher
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
  15. Maymó J, Pérez Pérez A, Dueñas J, Calvo J, Sanchez Margalet V, Varone C. Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways. Endocrinology. 2010;151:3738-51 pubmed publisher
    b>Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor...
  16. Liao Y, Liang K, Lee W, Lee W, Lee I, Wang J, et al. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. Biomarkers. 2013;18:44-50 pubmed publisher
    ..Adipokines were measured by ELISA tests. The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0...
  17. Chehab F, Lim M, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996;12:318-20 pubmed
    ..We show here that repeated administration of only the recombinant human ob protein, leptin, into homozygous female ob/ob mice can correct their sterility, thus resulting in ovulation, pregnancy and ..
  18. Chen H, Charlat O, Tartaglia L, Woolf E, Weng X, Ellis S, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84:491-5 pubmed
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  19. Bullo M, García Lorda P, Megias I, Salas Salvado J. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res. 2003;11:525-31 pubmed
    To explore the links between tumor necrosis factor alpha (TNFalpha) and leptin adipose tissue expression and low-grade systemic inflammation and to determine the relationship between inflammation and the degree of adiposity, the presence ..
  20. Chen K, Li F, Li J, Cai H, Strom S, Bisello A, et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med. 2006;12:425-32 pubmed
    The mechanisms underlying leptin resistance are still being defined...
  21. Geber S, Brandão A, Sampaio M. Effects of estradiol and FSH on leptin levels in women with suppressed pituitary. Reprod Biol Endocrinol. 2012;10:45 pubmed publisher
    ..b>Leptin regulates body weight and energy homeostasis...
  22. Uddin S, Bavi P, Hussain A, Alsbeih G, Al Sanea N, AbdulJabbar A, et al. Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication. Carcinogenesis. 2009;30:1832-40 pubmed publisher
    We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol 3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in vitro studies using a panel of CRC cell lines...
  23. McGaffin K, Moravec C, McTiernan C. Leptin signaling in the failing and mechanically unloaded human heart. Circ Heart Fail. 2009;2:676-83 pubmed publisher
    Increased circulating leptin is present in human heart failure, and leptin deficiency is linked to worse outcomes in chronic ischemic injury...
  24. Chen X, Zha X, Chen W, Zhu T, Qiu J, Røe O, et al. Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer. Biomed Pharmacother. 2013;67:22-30 pubmed publisher
    b>Leptin is a circulating peptide hormone, encoded by the obesity (ob) gene, acting as a regulator of food intake via hypothalamic-mediated effects...
  25. Barrenetxe J, Villaro A, Guembe L, Pascual I, Munoz Navas M, Barber A, et al. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. Gut. 2002;50:797-802 pubmed
    b>Leptin, a hormone mainly produced by fat cells, acts primarily on the hypothalamus regulating energy expenditure and food intake...
  26. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia. 2007;39:22-7 pubmed
    The aim of our study was to investigate the relationships between the expression of leptin, leptin receptor in the testis and spermatogenesis, and testosterone (T) concentration in infertile men...
  27. Silha J, Krsek M, Skrha J, Sucharda P, Nyomba B, Murphy L. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003;149:331-5 pubmed
    Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin...
  28. Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18:1354-62 pubmed
    Soluble leptin receptor (SLR) represents the major leptin binding activity in plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding of membrane-spanning receptors...
  29. Giordano C, Vizza D, Panza S, Barone I, Bonofiglio D, Lanzino M, et al. Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells. Mol Oncol. 2013;7:379-91 pubmed publisher
    ..confers risks to breast cancer development and progression, and several reports indicate that the adipokine leptin, whose synthesis and plasma levels increase with obesity, might play an important role in modulating breast cancer ..
  30. Minokoshi Y, Kim Y, Peroni O, Fryer L, Müller C, Carling D, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002;415:339-43 pubmed
    b>Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function...
  31. Wong S, Depaoli A, Lee J, Mantzoros C. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. J Clin Endocrinol Metab. 2004;89:2672-7 pubmed
    b>Leptin is an adipocyte-secreted hormone that regulates energy homeostasis and neuroendocrine function...
  32. Riolfi M, Ferla R, Del Valle L, Pina Oviedo S, Scolaro L, Micciolo R, et al. Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol. 2010;20:481-9 pubmed publisher
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  33. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32 pubmed
    ..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot. ..
  34. Patel N, Brinkman Van der Linden E, Altmann S, Gish K, Balasubramanian S, Timans J, et al. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J Biol Chem. 1999;274:22729-38 pubmed
    We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-..
  35. Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, et al. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab. 2002;87:4587-94 pubmed
    b>Leptin is bound in human blood by a high affinity binding protein, which appears to be identical with the soluble leptin receptor (sOB-R)...
  36. Erturk E, Kuru N, Savci V, Tuncel E, Ersoy C, Imamoglu S. Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. Fertil Steril. 2004;82:1364-8 pubmed
    To examine serum leptin concentrations in obese and lean patients with polycystic ovary syndrome (PCOS) to assess whether the changes in leptin levels are due to obesity or hormonal alterations. Controlled clinical study...
  37. Dubey L, Zeng H, Hashmi S, Hongjie W, Tao H. Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina. Int J Cardiol. 2008;126:183-9 pubmed
    ..By activating different immune/inflammatory cells or directly acting on the vessel wall leptin has been shown to play a potential role in the development of acute coronary syndrome...
  38. Wu M, Chuang P, Chen H, Lin C, Tsai S. Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. Mol Hum Reprod. 2002;8:456-64 pubmed
    ..b>Leptin is the product of the ob gene, which is related to reproductive function and immunological alteration...
  39. McLachlan K, O Neal D, Jenkins A, Alford F. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev. 2006;22:131-8 pubmed
    The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear...
  40. McMurtry V, Simeone A, Nieves Alicea R, Tari A. Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. Clin Exp Metastasis. 2009;26:197-204 pubmed publisher
    In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion...
  41. Cleveland R, Gammon M, Long C, Gaudet M, Eng S, Teitelbaum S, et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat. 2010;120:745-52 pubmed publisher
    ..b>Leptin is an important regulator of adipose tissue mass and has been associated with tumor cell growth...
  42. Mente A, Razak F, Blankenberg S, Vuksan V, Davis A, Miller R, et al. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care. 2010;33:1629-34 pubmed publisher
    To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  43. Mahutte N, Matalliotakis I, Goumenou A, Vassiliadis S, Koumantakis G, Arici A. Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis. Hum Reprod. 2003;18:1205-9 pubmed
    The role of leptin in reproductive processes has received increasing attention...
  44. van Lettow M, Van der Meer J, West C, van Crevel R, Semba R. Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi. J Clin Endocrinol Metab. 2005;90:4771-6 pubmed
    ..The purpose of this study was to determine whether leptin concentrations, in relation to the inflammatory cytokine response and level of HIV infection, are contributing to ..
  45. Abir R, Ao A, Jin S, Barnett M, Raanani H, Ben Haroush A, et al. Leptin and its receptors in human fetal and adult ovaries. Fertil Steril. 2005;84:1779-82 pubmed
    ..study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses...
  46. Rance K, Johnstone A, Murison S, Duncan J, Wood S, Speakman J. Plasma leptin levels are related to body composition, sex, insulin levels and the A55V polymorphism of the UCP2 gene. Int J Obes (Lond). 2007;31:1311-8 pubmed
    Circulating leptin levels show a high degree of individual variability even after the main effect of body fatness is accounted for...
  47. Cieslak J, Skorczyk A, Stachowiak M, Szydlowski M, Grzes M, Paczynska P, et al. Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents. Mol Biol Rep. 2011;38:1793-8 pubmed publisher
    ..In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) and a control group ..
  48. Lucantoni R, Ponti E, Berselli M, Savia G, Minocci A, Calo G, et al. The A19G polymorphism in the 5' untranslated region of the human obese gene does not affect leptin levels in severely obese patients. J Clin Endocrinol Metab. 2000;85:3589-91 pubmed
    ..presence of different polymorphisms in the regulatory region of the ob gene has been associated with variations in leptin levels. However, the results of these studies are still contradictory...
  49. Chan J, Heist K, Depaoli A, Veldhuis J, Mantzoros C. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest. 2003;111:1409-21 pubmed
    To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state and three 72-hour fasting studies ..
  50. Boute N, Zilberfarb V, Camoin L, Bonnafous S, Le Marchand Brustel Y, Issad T. The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion. Biochimie. 2004;86:351-6 pubmed
    b>Leptin is a cytokine secreted by the adipose tissue that is involved in the control of body weight...
  51. Cascio S, Bartella V, Auriemma A, Johannes G, Russo A, Giordano A, et al. Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha. Oncogene. 2008;27:540-7 pubmed
    We reported previously that the obesity hormone leptin is overexpressed in breast cancer biopsies...
  52. Li M, Ding G, Chen X, Lu X, Dong L, Dong M, et al. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2007;92:4771-6 pubmed
    ..was to evaluate whether polycystic ovarian syndrome (PCOS)-associated infertility is related to alterations of leptin, leptin receptor (Ob-R), and the phosphorylated signal transducer and activator of transcription 3 (p-STAT3)/..
  53. Esteghamati A, Khalilzadeh O, Anvari M, Rashidi A, Mokhtari M, Nakhjavani M. Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity. Metab Syndr Relat Disord. 2009;7:447-52 pubmed publisher
    b>Leptin is correlated with several features of metabolic syndrome; however, possible confounders (eg, obesity) of this association are not known...
  54. Li W, Hsiao K, Chen I, Chang Y, Wang S, Wu K. Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults. Cardiovasc Diabetol. 2011;10:36 pubmed publisher
    b>Leptin is associated with cardiovascular disease (CVD); however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population...
  55. McGarvey S, Forrest W, Weeks D, Sun G, Smelser D, Tufa J, et al. Human leptin locus (LEP) alleles and BMI in Samoans. Int J Obes Relat Metab Disord. 2002;26:783-8 pubmed
    ..These findings indicate that the leptin 3'-tetranucleotide repeat is associated with high BMI in adult Samoans, with allele 226 having a low frequency in ..
  56. Meier C, Chicheportiche R, Dreyer M, Dayer J. IP-10, but not RANTES, is upregulated by leptin in monocytic cells. Cytokine. 2003;21:43-7 pubmed
    We and others have previously shown that leptin has direct effects on the function of monocytes and macrophages...
  57. Niv Spector L, Gonen Berger D, Gourdou I, Biener E, Gussakovsky E, Benomar Y, et al. Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists. Biochem J. 2005;391:221-30 pubmed publisher
    Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through binding sites I-III...
  58. Farooqi I, Bullmore E, Keogh J, Gillard J, O Rahilly S, Fletcher P. Leptin regulates striatal regions and human eating behavior. Science. 2007;317:1355 pubmed
    Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation...
  59. Golledge J, Clancy P, Jamrozik K, Norman P. Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. Circulation. 2007;116:2275-9 pubmed
    ..26; 95% CI, 1.07 to 1.50) but not AAA > or = 40 mm (OR, 1.03; 95% CI, 0.77 to 1.39). Serum leptin was not associated with AAA. Measures of obesity are independently associated with AAA...
  60. Strobel A, Issad T, Camoin L, Ozata M, Strosberg A. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet. 1998;18:213-5 pubmed
  61. Chan J, Bluher S, Yiannakouris N, Suchard M, Kratzsch J, Mantzoros C. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes. 2002;51:2105-12 pubmed
    b>Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological processes...
  62. Alemán M, Santolaria F, Batista N, de La Vega M, Gonzalez Reimers E, Milena A, et al. Leptin role in advanced lung cancer. A mediator of the acute phase response or a marker of the status of nutrition?. Cytokine. 2002;19:21-6 pubmed
    b>Leptin is an anorexia inductor peptide produced by adipocytes and related to fat mass. Leptin is also produced by fat under proinflammatory cytokine action...
  63. Koutkia P, Canavan B, Johnson M, Depaoli A, Grinspoon S. Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin. Am J Physiol Endocrinol Metab. 2003;285:E372-9 pubmed
    To investigate the regulation of leptin secretion and pulsatility by fat mass, we performed overnight leptin sampling every 20 min for 12 h and compared leptin dynamics with total body and regional fat measurements in 20 healthy male ..
  64. Willett E, Skibola C, Adamson P, Skibola D, Morgan G, Smith M, et al. Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer. 2005;93:811-6 pubmed
    ..9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL ..
  65. Soderberg S, Zimmet P, Tuomilehto J, Chitson P, Gareeboo H, Alberti K, et al. Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study. Int J Obes (Lond). 2007;31:1126-33 pubmed
    To determine if levels of the adipocyte-derived hormone, leptin, predict the development of type 2 diabetes. Population-based surveys were undertaken in the multiethnic nation of Mauritius in 1987, 1992 and 1998...
  66. Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002;147:173-80 pubmed
    ..To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women...
  67. Mórocz M, Czibula A, Grózer Z, Szécsényi A, Almos P, Raskó I, et al. Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2011;36:E123-30 pubmed publisher
    ..to reveal implication of promoter polymorphisms of bone morphogenetic protein 4 (BMP4), interleukin-6 (IL6), leptin, matrix metalloproteinase-3 (MMP3), melatonin 1B receptor (MTNR1B) genes in adolescent idiopathic scoliosis (AIS)...
  68. Wolk R, Deb A, Caplice N, Somers V. Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis. 2005;183:131-9 pubmed
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  69. Montague C, Farooqi I, Whitehead J, Soos M, Rau H, Wareham N, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:903-8 pubmed
    The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure...
  70. Mattevi V, Zembrzuski V, Hutz M. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-85 pubmed
    ..001). Our findings suggest that genetic variability in the leptin receptor and neuropeptide Y genes is implicated in body weight regulation, the LEPR Gln223Arg variant being ..
  71. Coskun U, Gunel N, Toruner F, Sancak B, Onuk E, Bayram O, et al. Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer. Neoplasma. 2003;50:41-6 pubmed
    ..VEGF is an important regulator of tumor angiogenesis. Both leptin and prolactin have also been suggested to have roles in the regulation of angiogenic process...
  72. Catalano S, Marsico S, Giordano C, Mauro L, Rizza P, Panno M, et al. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J Biol Chem. 2003;278:28668-76 pubmed
    b>Leptin, a product of adipocytes, is involved in the regulation of body weight and results strongly correlated to body fat content...
  73. Ducroc R, Guilmeau S, Akasbi K, Devaud H, Buyse M, Bado A. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. Diabetes. 2005;54:348-54 pubmed
    The effect of leptin on glucose transport was studied in rat jejunal mucosa in Ussing chambers. Leptin was added in the luminal or the serosal compartment before the tissues were challenged with 1, 10, or 50 mmol/l glucose...
  74. Bedaiwy M, Falcone T, Goldberg J, Sharma R, Nelson D, Agarwal A. Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients. Hum Reprod. 2006;21:788-91 pubmed
    b>Leptin influences the proinflammatory immune responses and has angiogenic activity in vitro and in vivo...
  75. Brennan A, Mantzoros C. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006;2:318-27 pubmed
    b>Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis...
  76. Hart Sailors M, Folsom A, Ballantyne C, Hoelscher D, Jackson A, Linda Kao W, et al. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab. 2007;9:548-57 pubmed
    To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in ..
  77. Teras L, Goodman M, Patel A, Bouzyk M, Tang W, Diver W, et al. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:2553-7 pubmed publisher
    There is evidence that adipokines such as leptin and adiponectin may influence breast tumor development...
  78. Franek E, Nowak J, Safranow K, Adler G, Binczak Kuleta A, Ciechanowicz A, et al. G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass. Pol Arch Med Wewn. 2010;120:175-80 pubmed
    ..of the present study was to assess whether these discrepancies might be associated with the effect of G(-2548)A leptin or A326G and A668G leptin receptor gene polymorphisms on serum leptin concentrations or BMD and BMC...
  79. Ushiroyama T, Ikeda A, Hosotani T, Higashiyama T, Ueki M. Inverse correlation between serum leptin concentration and vertebral bone density in postmenopausal women. Gynecol Endocrinol. 2003;17:31-6 pubmed
    ..The present study of 215 postmenopausal Japanese women investigated whether circulating leptin concentration was correlated with per cent fat mass or age-adjusted bone mineral density (Z-score)...