leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human

Top Publications

  1. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
  2. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
  3. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
  4. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  5. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
  6. pmc Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
  7. ncbi Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    Grazia Ambrosini
    Department of Molecular Biology, Institute for Diabetes Discovery, 25 Business Park Drive, Branford, CT 06405, USA
    J Biol Chem 277:34601-9. 2002
  8. ncbi Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    Alexandra Nieters
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nutr 41:210-21. 2002
  9. ncbi C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
  10. doi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011

Detail Information

Publications269 found, 100 shown here

  1. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system...
  2. ncbi Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
    ..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot...
  3. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
    The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure...
  4. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  5. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
    b>Leptin controls food intake and energy expenditure by regulating hypothalamic neuron activities...
  6. pmc Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
    The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in ..
  7. ncbi Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
    Grazia Ambrosini
    Department of Molecular Biology, Institute for Diabetes Discovery, 25 Business Park Drive, Branford, CT 06405, USA
    J Biol Chem 277:34601-9. 2002
    In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic cytokine with multiple physiological effector functions...
  8. ncbi Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    Alexandra Nieters
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nutr 41:210-21. 2002
    ....
  9. ncbi C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
    ..Although CRP was positively correlated with body mass index (BMI), percent fat mass, and serum leptin, correlations with BMI (r = 0.15, P =.05) and percent body fat (r = 0.16, P =...
  10. doi Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis
    Mónika Mórocz
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari korut 62, H 6726, Szeged, Hungary
    Spine (Phila Pa 1976) 36:E123-30. 2011
    ..a genetic association study was performed on 126 patients with adolescent idiopathic scoliosis and 197 healthy controls from independent Hungarian pedigrees...
  11. ncbi G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
    Tsu Nai Wang
    Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Obesity (Silver Spring) 14:183-7. 2006
    We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity...
  12. ncbi Leptin indirectly activates human neutrophils via induction of TNF-alpha
    Hamid Zarkesh-Esfahani
    Division of Clinical Sciences North, University of Sheffield, Sheffield, United Kingdom
    J Immunol 172:1809-14. 2004
    b>Leptin, the satiety hormone, appears to act as a link between nutritional status and immune function...
  13. ncbi Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion
    Marco R Schroeter
    Department of Cardiology and Pulmonary Medicine, University of Goettingen, Robert Koch Strasse 40, D 37099 Goettingen, Germany
    Circ Res 103:536-44. 2008
    The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro and in vivo...
  14. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  15. doi Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity
    Alireza Esteghamati
    Endocrinology and Metabolism Research Center EMRC, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Metab Syndr Relat Disord 7:447-52. 2009
    b>Leptin is correlated with several features of metabolic syndrome; however, possible confounders (eg, obesity) of this association are not known...
  16. ncbi Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002
    b>Leptin is synthesized in adipocytes and acts primarily through central pathways suppressing appetite and increasing the metabolic rate in rodents as well as in humans...
  17. ncbi Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming
    Benedetta Mattioli
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 174:6820-8. 2005
    b>Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis. Leptin is capable of modulating several immune responses...
  18. ncbi OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily
    N Patel
    Molecular Biology Department, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 274:22729-38. 1999
    We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-..
  19. ncbi Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer
    Christos Yapijakis
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Kifissias and Perikleous Stavrou 9, 11524, Athens, Greece
    J Cancer Res Clin Oncol 135:603-12. 2009
    We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for ..
  20. doi Association of plasma leptin levels and insulin resistance in diabetic women: a cross-sectional analysis in an Iranian population with different results in men and women
    Manouchehr Nakhjavani
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, School of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Gynecol Endocrinol 27:14-9. 2011
    The objective of this study was to assess the association of serum leptin levels with insulin resistance (IR), metabolic syndrome (MetS), lipid levels, and glucose control in an Iranian type 2 diabetic population.
  21. ncbi Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways
    Julieta L Maymó
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Endocrinology 151:3738-51. 2010
    b>Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor...
  22. doi Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Endocr Relat Cancer 17:191-202. 2010
    The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary human malignancies has been reported; however, their role in papillary thyroid cancer (PTC) has not yet been evaluated...
  23. doi Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels
    Peter Koncsos
    First Department of Medicine, University of Debrecen, Debrecen, Hungary
    Pediatr Res 67:309-13. 2010
    ..Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied...
  24. ncbi The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion
    N Boute
    Department of Cell Biology, Institut Cochin, UMR CNRS 8104, INSERM U567, Universite Paris 5, 22, Rue Mechain, 75014 Paris, France
    Biochimie 86:351-6. 2004
    b>Leptin is a cytokine secreted by the adipose tissue that is involved in the control of body weight...
  25. ncbi Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
    Alexandra Grosfeld
    INSERM U 465, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:42953-7. 2002
    Increased placental leptin has been demonstrated in preeclampsia, a pregnancy disorder associated with placental hypoxia. This suggests that leptin gene expression is enhanced in response to oxygen deficiency in this organ...
  26. pmc The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    Jean L Chan
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1409-21. 2003
    To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an acute fast, six to eight healthy, lean men were studied under four separate conditions: a baseline fed state and three 72-hour fasting studies ..
  27. doi The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility
    Yu Tao
    Department of Obstetrics Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
    Am J Reprod Immunol 65:403-6. 2011
    To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-α in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility.
  28. pmc Development and characterization of high affinity leptins and leptin antagonists
    Michal Shpilman
    Robert H Smith Faculty of Agriculture, Food and Environment, Hebrew University, Rehovot 76100, Israel
    J Biol Chem 286:4429-42. 2011
    b>Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in a variety of biological processes, including energy metabolism, reproduction, and modulation of the immune response...
  29. doi Association between the chondrocyte phenotype and the expression of adipokines and their receptors: evidence for a role of leptin but not adiponectin in the expression of cartilage-specific markers
    Pierre Jean Francin
    UMR CNRS UHP 7561, Faculte de Medecine, Vandoeuvre les Nancy, France
    J Cell Physiol 226:2790-7. 2011
    ..The expression of leptin, adiponectin and their receptors, as well as cartilage-specific genes was examined in chondrocytes obtained from ..
  30. ncbi Relationship between leptin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney disease
    A Atamer
    Department of Internal Medicine, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey
    J Int Med Res 36:522-8. 2008
    This study examined the relationship between leptin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3) and insulin resistance in patients with chronic kidney disease (CKD)...
  31. ncbi Leptin and its receptors in human fetal and adult ovaries
    Ronit Abir
    Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Fertil Steril 84:1779-82. 2005
    ..study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses...
  32. ncbi Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training
    Antti Huuskonen
    Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    Cell Biochem Funct 28:306-12. 2010
    b>Leptin regulates body weight, metabolism, and tissue adaptations to environmental stressors...
  33. pmc Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome
    Sabine Zirlik
    Medical Department 1, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Med Sci Monit 17:CR159-64. 2011
    Recent studies suggest that adipose tissue hormones are involved in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). The role of leptin, obestatin and apelin still needs to be established.
  34. ncbi Leptin expression by annulus cells in the human intervertebral disc
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232, USA
    Spine J 7:437-43. 2007
    It is now known that leptin acts not only as a metabolic signal related to energy homeostasis but also as an endocrine hormone regulating traditional endocrine systems and neuroendocrine function in various cells...
  35. doi Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness
    B Gwen Windham
    Department of Internal Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 23:501-7. 2010
    ..adipocytes account for most adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness.
  36. ncbi The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients
    S Ben Ali
    Research Laboratory LAB SM 01, Biochemistry Department, Rabta Hospital, Tunis, Tunisia
    Blood Press 17:278-83. 2008
    To examine the association of a common -2548G/A (rs7799039) promoter variant of the human leptin gene (LEP) with obesity or body mass index (BMI) and its associated phenotypes such as blood pressure variability and the prevalence of ..
  37. ncbi Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain
    Olga Portoles
    Genetic and Molecular Epidemiology Unit Department of Preventive Medicine and Public Health School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Eur J Epidemiol 21:605-12. 2006
    ..In animal models, the leptin (LEP) and the leptin receptor (LEPR) genes have been shown to be very important in obesity because leptin ..
  38. doi Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents
    Jakub Cieslak
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60 637 Poznan, Poland
    Mol Biol Rep 38:1793-8. 2011
    ..In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) and a control group ..
  39. ncbi Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy
    Kylie A McLachlan
    Department of Endocrinology, St Vincents Hospital, Victoria, Australia
    Diabetes Metab Res Rev 22:131-8. 2006
    The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance of pregnancy is not clear...
  40. ncbi Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans
    Mary Yannakoulia
    Department of Nutrition Dietetics, Harokopio University, 17671 Athens, Greece
    J Clin Endocrinol Metab 88:1730-6. 2003
    The adipocyte-derived hormones leptin [which circulates in a free form and bound to a soluble leptin receptor (sOB-R)], adiponectin, and resistin play a key role in regulating energy homeostasis and metabolism...
  41. ncbi Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway
    Antonio Pérez-Pérez
    Departamento de Bioquimica Medica y Biologia Molecular, Facultad de Medicina Hospital Universitario Virgen Macarena, Universidad de Sevilla, Espana, Spain
    Arch Biochem Biophys 477:390-5. 2008
    b>Leptin (Ob), the peripheral signal produced by the adipocyte to regulate energy metabolism, can also be produced by placenta, where it may work as an autocrine hormone...
  42. ncbi Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis
    M C Park
    Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea
    Scand J Rheumatol 36:101-6. 2007
    To determine whether serum leptin levels are elevated in men with ankylosing spondylitis (AS) and whether the levels correlate with serum cytokine profiles and disease activity of AS.
  43. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..SCD1 is suppressed by leptin but induced by insulin. We have used animal models to dissect the effects of these hormones on SCD1...
  44. ncbi Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
    ..b>Leptin, IL6 and adiponectin can be considered as adiposity signals...
  45. ncbi Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    Jean L Chan
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 51:2105-12. 2002
    b>Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological processes...
  46. ncbi Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  47. doi Up-regulation of placental leptin by human chorionic gonadotropin
    Julieta L Maymó
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidas de Buenos Aires, Buenos Aires, Argentina
    Endocrinology 150:304-13. 2009
    b>Leptin, the 16,000 molecular weight protein product of the obese gene, was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism...
  48. ncbi Are the associations of plasma leptin and adiponectin with type 2 diabetes independent of obesity in older Chinese adults?
    Zhiqiang Wang
    Centre for Chronic Disease, School of Medicine, University of Queensland, Herston, QLD 4029, Australia
    Diabetes Metab Res Rev 26:109-14. 2010
    China has experienced a rapid increase in diabetes. In this study, we assessed whether the associations of two adipocyte-derived hormones, leptin and adiponectin, with type 2 diabetes are independent of obesity in older Chinese adults.
  49. ncbi Crystal structure of the obese protein leptin-E100
    F Zhang
    Research Technologies and Proteins, Endocrine Research Divisions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 387:206-9. 1997
    ..The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest...
  50. doi Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells
    Marianna Terrasi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Int J Cancer 125:1038-44. 2009
    b>Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity-related stimuli...
  51. ncbi Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients
    Takiko Yanagawa
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka Japan
    Diabetes Res Clin Pract 75:2-6. 2007
    ..glucose, and serum lipids (triglycerides, HDL cholesterol, and total cholesterol), interleukin 6 (IL-6), and leptin were measured...
  52. ncbi Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi
    Monique van Lettow
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 90:4771-6. 2005
    ..Wasting is a prominent feature of tuberculosis and may be more severe among individuals with HIV coinfection. It is likely that several biological mechanisms, including the anorexia of infection, are contributing to wasting...
  53. pmc Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults
    Wen Cheng Li
    Department of Occupation Medicine, Chang Gung Memorial Hospital, Keelung Branch, NO, 222, Maijin Rd, Keelung, Taiwan
    Cardiovasc Diabetol 10:36. 2011
    b>Leptin is associated with cardiovascular disease (CVD); however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population...
  54. ncbi Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line
    Stefania Catalano
    Centro Sanitario and the Department of PharmacoBiology, Faculty of Pharmacy, University of Calabria, 87030 Arcavacata di Rende, Italy
    J Biol Chem 278:28668-76. 2003
    b>Leptin, a product of adipocytes, is involved in the regulation of body weight and results strongly correlated to body fat content...
  55. pmc Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy
    Mirko Riolfi
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Brain Pathol 20:481-9. 2010
    Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown...
  56. ncbi Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome
    Mei Gen Li
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 31006, China
    J Clin Endocrinol Metab 92:4771-6. 2007
    ..was to evaluate whether polycystic ovarian syndrome (PCOS)-associated infertility is related to alterations of leptin, leptin receptor (Ob-R), and the phosphorylated signal transducer and activator of transcription 3 (p-STAT3)/..
  57. ncbi Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    Vanity McMurtry
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
    Clin Exp Metastasis 26:197-204. 2009
    In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion...
  58. ncbi Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    Robert Wolk
    Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
    Atherosclerosis 183:131-9. 2005
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  59. ncbi Leptin induces endothelin-1 in endothelial cells in vitro
    Peter Quehenberger
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Circ Res 90:711-8. 2002
    b>Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure...
  60. ncbi Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication
    Shahab Uddin
    Human Cancer Genomic Research, Research Centre, Saudi Arabia
    Carcinogenesis 30:1832-40. 2009
    We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol 3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in vitro studies using a panel of CRC cell lines...
  61. ncbi Circulating leptin and angiogenic factors in preeclampsia patients
    Hideki Nakatsukasa
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Endocr J 55:565-73. 2008
    b>Leptin, one of adipocytokines, plays a wide range of important roles in reproductive biology. We have previously reported that low hypo-adiponectinemia might be involved in the pathophysiology of overweight preeclampsia (PE) patients...
  62. doi Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 122:33-42. 2012
    b>Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes...
  63. pmc Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells
    Mustapha Zeddou
    Laboratory of Rheumatology, GIGA I3, GIGA Research Centre, University and CHU of Liege, Liege, Belgium
    Stem Cells Dev 21:1948-55. 2012
    b>Leptin plays a central role in maintaining energy balance, with multiple other systemic effects...
  64. pmc Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes
    Anja J Gerrits
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haematologica 97:1149-57. 2012
    ..Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin resistance...
  65. ncbi Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects
    C E Ezenwaka
    The University of the West Indies, St Augustine, Trinidad
    Arch Physiol Biochem 115:22-7. 2009
    To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.
  66. pmc Leptin regulates striatal regions and human eating behavior
    I Sadaf Farooqi
    University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Science 317:1355. 2007
    Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation...
  67. pmc Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts
    Fabian B Fahlbusch
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Reprod Biol Endocrinol 10:80. 2012
    ..Intrauterine growth restriction (IUGR) is accompanied by an increase in placental CRH, which could be of pathophysiological relevance for the dysregulation in syncytialisation seen in IUGR placentas...
  68. ncbi Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients
    Kokona Chatzantoni
    Experimental Hematology and Transfusion Medicine, Medical School and University Hospital, University of Patras, Patras, Greece
    J Autoimmun 23:169-77. 2004
    b>Leptin is synthesized by adipocytes to regulate appetite. Leptin has also been implicated in the pathogenesis of multiple sclerosis (MS) leading to speculation about a beneficial effect of fasting to autoimmune patients...
  69. ncbi Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients
    S Maestrini
    Molecular Biology Laboratory, Ospedale San Giuseppe, Istituto Auxologico Italiano, Verbania, Italy
    J Endocrinol Invest 29:776-80. 2006
    Conflicting data suggest an association between leptin gene polymorphisms and essential hypertension independently of obesity...
  70. ncbi Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study
    M L Hart Sailors
    Department of Pediatrics, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Diabetes Obes Metab 9:548-57. 2007
    To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in ..
  71. ncbi Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor
    Mitsuru Shimamura
    Biomedical Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Biochem Biophys Res Commun 322:1080-5. 2004
    ..The current study examined the regulation of Angptl3 by leptin and insulin, both of which are key players in the metabolic syndrome...
  72. ncbi Leptin: a potential marker of placental insufficiency
    Jacques Lepercq
    Service de Gynecologie Obstetrique, Hopital Cochin Saint Vincent de Paul, Paris, France
    Gynecol Obstet Invest 55:151-5. 2003
    To investigate placental leptin production in placental insufficiency, placental leptin production was measured in women with severe preeclampsia (group 1) and in normotensive pregnancies associated with intrauterine growth restriction (..
  73. ncbi G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass
    Edward Franek
    Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital, Ministry for Internal Affairs, Warsaw, Poland
    Pol Arch Med Wewn 120:175-80. 2010
    ..Clinical studies have shown either positive or in some other cases negative correlations between leptinemia and bone mineral density (BMD) or bone mineral content (BMC)...
  74. ncbi Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin
    Ju Young Kim
    Laboratory of Hematopoiesis and Hematologic Malignancy, Cancer Research Institute, Seoul National University, College of Medicine, Seoul, Korea
    Oncol Rep 23:1369-74. 2010
    b>Leptin acts as a growth factor in normal cells as well as in various types of cancer cells. We investigated the effects of leptin on human acute myelogenous leukemia (AML) cells...
  75. doi Relation between first trimester maternal serum leptin levels and body mass index in normotensive and pre-eclamptic pregnancies--role of leptin as a marker of pre-eclampsia: a prospective case-control study
    Sofoklis Samolis
    Department of Obstetrics and Gynaecology Tzaneio General Hospital, Pireaus, Greece
    Gynecol Endocrinol 26:338-43. 2010
    We measured first trimester plasma leptin concentrations in 37 women who subsequently developed pre-eclampsia and 53 normotensive controls to determine the interrelation between leptin and body mass index (BMI) in both groups...
  76. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults...
  77. ncbi Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina
    Laxman Dubey
    Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology HUST, Wuhan 430030, Hubei, PR China
    Int J Cardiol 126:183-9. 2008
    ..By activating different immune/inflammatory cells or directly acting on the vessel wall leptin has been shown to play a potential role in the development of acute coronary syndrome...
  78. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  79. pmc Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample
    Erik Ingelsson
    The Framingham Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    J Clin Endocrinol Metab 93:3149-57. 2008
    The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown.
  80. doi The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    Takuro Furusawa
    Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
    Hum Genet 127:287-94. 2010
    ..This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor ..
  81. ncbi A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin
    J Hoffstedt
    Department of Medicine at Huddinge University Hospital, Stockholm, Sweden
    Horm Metab Res 34:355-9. 2002
    There is a large inter-individual variation in circulating leptin concentrations at each level of body fat content. The reason for this is unknown...
  82. ncbi Leptin mediates a proliferative response in human MCF7 breast cancer cells
    Marie Noelle Dieudonne
    Service de Biochimie et Biologie Moléculaire, Faculté de médecine Paris Ouest, Centre Hospitalier de Poissy, Université Descartes Paris V, 78303 Poissy Cedex, France
    Biochem Biophys Res Commun 293:622-8. 2002
    Obesity is a risk factor of breast cancers. As leptin, a hormone mainly secreted by white adipocytes, elicits proliferative effects in some cell types, we tested the hypothesis that leptin could influence human breast cancer MCF-7 cell ..
  83. ncbi Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    Takeo Ogawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Metabolism 53:879-85. 2004
    b>Leptin plays an important role in the regulation of body weight and is known to circulate in both free and bound forms. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin...
  84. ncbi Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease
    Ricardo Ribeiro
    Molecular Oncology Unit, Instituto Portugues de Oncologia, Porto, Portugal
    Prostate 59:268-74. 2004
    b>Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele).
  85. ncbi Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers
    Marialena Kyriakakou
    Neonatal and Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, 10682 Athens, Greece
    Eur J Endocrinol 158:343-8. 2008
    b>Leptin and adiponectin are two adipocytokines that play a critical role in the control of energy balance and metabolism as well as in conditions, such as insulin resistance, inflammation, and the development of the metabolic syndrome in ..
  86. ncbi Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue
    H Masuzaki
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Diabetes 44:855-8. 1995
    ..This study is the first report of the elucidation of ob gene expression in human tissues, thereby leading to better understanding of the physiological and clinical implications of the ob gene...
  87. ncbi A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure...
  88. doi Leptin-mediated cytoskeletal remodeling in chondrocytes occurs via the RhoA/ROCK pathway
    Jinqian Liang
    Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
    J Orthop Res 29:369-74. 2011
    b>Leptin affects a number of cell signaling pathways, at present, the mechanism(s) by which leptin affects the cartilage cells in OA patient is not well understood...
  89. ncbi Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways
    Bartolome Burguera
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Med Sci Monit 12:BR341-9. 2006
    Serum leptin levels are strongly and directly related to fat body mass (FBM). Bone mineral density (BMD) increases with FBM, and obesity has a protective effect against osteoporosis...
  90. ncbi The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    E D Green
    Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 5:5-12. 1995
    ....
  91. ncbi Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis
    Yong Qiu
    Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Spine (Phila Pa 1976) 32:2703-10. 2007
    A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS).
  92. ncbi Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults
    Caroline T M van Rossum
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Obes Res 11:377-86. 2003
    To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain.
  93. ncbi Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter
    Ingo Melzner
    Department of Pathology, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Biol Chem 277:45420-7. 2002
    The peptide hormone leptin plays a major role in the regulation of energy intake and expenditure and is predominantly expressed in mature adipocytes but not in preadipocytes...
  94. ncbi LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals
    Hamilton M Hinuy
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Sao Paulo University, Sao Paulo, SP, Brazil
    Mol Genet Metab 89:374-80. 2006
    b>Leptin plays an important role in satiety signaling and is related to obesity. Variants of leptin gene (LEP) have been associated to differences in plasma leptin levels and obesity-related phenotypes...
  95. ncbi Influence of nutritional recovery on the leptin axis in severely malnourished children
    Katja Stein
    Institute of Nutrition, Friedrich Schiller University, Dornburger Strasse 24, D 07743 Jena, Germany
    J Clin Endocrinol Metab 91:1021-6. 2006
    b>Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood.
  96. ncbi Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease
    E Porreca
    Department of Medicine and Aging, and Aging Research Center, CeSI, GD Annunzio University Foundation, Chieti Pescara, Italy
    Int J Obes (Lond) 30:209-13. 2006
    ..No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease...
  97. pmc The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes
    Diamantis Konstantinidis
    Laboratory of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Cell Stress Chaperones 14:591-601. 2009
    b>Leptin, a 16-kDa cytokine produced mainly by the adipose tissue, is known to increase energy expenditure while at the same time lowering food intake by acting directly on the hypothalamus...
  98. ncbi Leptin and coronary heart disease risk: prospective case control study of British women
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Obesity (Silver Spring) 15:1694-701. 2007
    Prospective studies have shown a positive association between leptin concentrations and coronary heart disease (CHD) in men, but its effect in women is unclear...
  99. ncbi IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
    Diabetes 56:2705-9. 2007
    ..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures.
  100. ncbi Contribution of leptin receptor N-linked glycans to leptin binding
    Yuichi Kamikubo
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 410:595-604. 2008
    The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated...
  101. doi Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation
    Chang Qing Zhao
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Spine (Phila Pa 1976) 33:E858-64. 2008
    ..Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Human Ethics Review Committee and Animal Care and Use Committee...

Research Grants84

  1. Determination of the Mechanisms by which IGFBP-2 Stimulates Bone Remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..Taken together, we hypothesize that IGFBP-2, which is induced by IGF-I, stimulates MSCs and OBs through HBD1...
  2. Using Real-time Speech Translation for Medication Therapy Management of Spanish S
    FARZAD EHSANI; Fiscal Year: 2013
    ....
  3. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2004
    ..These experiments will validate IKKbeta as a major mediator of insulin resistance and as a useful target for the discovery of new drugs to treat type 2 diabetes and insulin resistance. ..
  4. Insulin Resistance in Tissue Specific IKKB Transgenics
    Jongsoon Lee; Fiscal Year: 2003
    ..These experiments will validate IKKbeta as a major mediator of insulin resistance and as a useful target for the discovery of new drugs to treat type 2 diabetes and insulin resistance. ..
  5. Regulation of Osteoblast Function by Megakaryocytes: Key Signaling Proteins
    Melissa A Kacena; Fiscal Year: 2012
    ..However, our histological evaluation of GATA-1 and NF-E2 deficient mice reveals higher numbers of osteoblasts (OBs) on trabecular surfaces...
  6. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..disrupted bone given the circumstances that mesenchymal stem cells (MSCs) can differentiate into osteoblasts (OBs) and that new blood supply can be re-established...
  7. A megakaryocyte/PGE2/osteoblast triad in the normal and aged niche
    Louis M Pelus; Fiscal Year: 2013
    ..role of megakaryocytes (MKs) produced by the hematopoietic system in stimulating bone formation by osteoblasts (OBs);findings in the Pelus laboratory that define important roles for the major eicosanoid prostaglandin E2 (PGE2) in ..
  8. SYNTHESIS OF OSTEOCALCIN IN BONE
    Jane B Lian; Fiscal Year: 2013
    ..epigenetic marking of the OC gene for tissue specific activation, and regulation of target gene expression in OBs. Its deletion from OB in vitro and in vivo is postulated to alter OB maturation and contribute to a mild bone ..
  9. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2013
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  10. Depression Screening in Primary Care: Using HIT for Patients with Limited English
    Dara H Sorkin; Fiscal Year: 2013
    ....
  11. Advancing Patient Call Light Systems to Achieve Better Outcomes
    Amy Wilson-Stronks; Fiscal Year: 2013
    ....
  12. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board
    MARY E HAPP; Fiscal Year: 2013
    ..The commercial opportunity lies in becoming the standard of care by facilitating effective communication to improve the care and comfort of patients in critical care units. ..
  13. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board
    MARY E HAPP; Fiscal Year: 2013
    ..The commercial opportunity lies in becoming the standard of care by facilitating effective communication to improve the care and comfort of patients in critical care units. ..
  14. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    DEAN YAMAGUCHI; Fiscal Year: 2009
    ..full repair of bone given the circumstances that mesenchymal stem cells (MSCs) can differentiate into osteoblasts (OBs) and that new blood supply can be re-established...
  15. Hospital Quality Reports for Expectant Mothers: Considering Race and Language
    Tetine Sentell; Fiscal Year: 2013
    ..We will use this information to design and test a personalized, consumer-focused website with the goal of improving the use of public hospital quality reports for pregnant women across diverse racial/ethnic and linguistic groups. ..
  16. Nrf1 Molecular Pathway, Vitamin C Deficiency, and Spontaneous Fractures
    Subburaman Mohan; Fiscal Year: 2013
    ..expression of osterix (Osx), a master osteogenic transcription factor, during differentiation of osteoblasts (OBs)...
  17. Impact of Physician non-English Language Proficiency Level on Cancer Screening
    Lisa C Diamond; Fiscal Year: 2013
    ..Level one will assess the probability of completing cancer screening at the patient level, including the covariates listed above. Level 2 will account for clinician factors listed above and level 3 will include clinician work sites. ..
  18. Disparities in Chronic Illness Care for Patients with Language Barriers
    LEO SERGIO MORALES; Fiscal Year: 2013
    ..abstract_text> ..
  19. Advancing Patient Call Light Systems to Achieve Better Outcomes
    Amy Wilson-Stronks; Fiscal Year: 2012
    ..All of these failures sustain a health care environment with unnecessary risk factors that contribute to inefficiencies in nursing care processes, poor quality of care and patient safety failures. ..
  20. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen Gravallese; Fiscal Year: 2009
    ..However, data from our laboratory demonstrate a defect in the maturation of bone-forming osteoblasts (OBs) at sites of articular bone loss (erosions), with an accompanying inhibition in the formation of mineralized bone ..
  21. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen M Gravallese; Fiscal Year: 2010
    ..However, data from our laboratory demonstrate a defect in the maturation of bone-forming osteoblasts (OBs) at sites of articular bone loss (erosions), with an accompanying inhibition in the formation of mineralized bone ..
  22. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2003
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  23. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2001
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  24. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2004
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  25. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  26. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2002
    ..of this proposal is (1) to examine whether viral vector mediated delivery of weight-reducing signals, such as leptin, is a viable therapy (gene therapy), alternative to the pharmacologic approach, to control body weight (BW) gain ..
  27. Mechanobiology of 3D Trabecular Bone Explants
    X Guo; Fiscal Year: 2009
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  28. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2010
    ..a central scientific hypothesis that that dynamic deformational loading induces OCYs to send anabolic signals to OBs to promote bone formation through intraceluar calcium [Ca2+]i oscillations in osteocytic network, followed by ..
  29. Medication Summary Guides for Vulnerable Populations with Rheumatoid Arthritis
    Edward H Yelin; Fiscal Year: 2010
    ....
  30. Regulation of apoptosis in osteoblasts by Runx2 and NFkB
    Roman Eliseev; Fiscal Year: 2013
    ..growth and remodeling of bone tissue, bone cells differentiate from mesenchymal stem cells to early proliferating OBs to mature post-mitotic OBs of which 30 percent become either osteocytes or lining cells while 70 percent are ..
  31. ETHANOL, ESOPHAGEAL DYSMOTILITY, AND CA2+ REGULATION
    Ali Keshavarzian; Fiscal Year: 1992
    ..These experiments should not only reveal the mechanism for EIED but also, confirm that functional changes in excitable tissue correlate with altered C12+ regulation...
  32. ETHANOL, ESOPHAGEAL DYSMOTILITY, AND CA2+ REGULATION
    Ali Keshavarzian; Fiscal Year: 1993
    ..These experiments should not only reveal the mechanism for EIED but also, confirm that functional changes in excitable tissue correlate with altered C12+ regulation...
  33. Modulation of Human Immunity by Mycobacterium leprae
    CLAUDIA M A MANCA; Fiscal Year: 2013
    ..The results of our proposed studies will facilitate the development of improved pharmacologic and/or vaccine strategies that can contribute to leprosy control. ..
  34. BEHAVIORAL INTERVENTION FOR CHILDREN WITH CANCER
    Lonnie Zeltzer; Fiscal Year: 1990
    ..Pain and anxiety will be assessed in children (5-10 years) using patient (pt.) and observer (obs.) ratings and a behavioral checklist during 2 bone marrow aspirations and/or 2 lumbar punctures prior to ..
  35. TDARS: Translated Document Assembly and Retrieval System (Phase II)
    CYNTHIA ROAT; Fiscal Year: 2010
    ..Both the Agency for Healthcare Research and Quality (AHRQ) and the Office of Minority Health (OMH) have indicated that creating such a repository is a national priority. ..
  36. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2010
    ..to support OC formation, increase SC production of osteoclastogenic cytokines, and promote SC differentiation into OBs through stimulation of CD40 signaling in SCs by T cell expressed CD40L...
  37. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2005
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  38. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2009
    ..to support OC formation, increase SC production of osteoclastogenic cytokines, and promote SC differentiation into OBs through stimulation of CD40 signaling in SCs by T cell expressed CD40L...
  39. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  40. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2003
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  41. BIOCHEMICAL CHARACTERIZATION OF GBS HYALURONATE LYASE
    David Pritchard; Fiscal Year: 1999
    B streptococci (OBS) are presently the most frequent cause of serious, often fatal, bacterial infections of neonates in the United States and are also a common cause of peripartum maternal sepsis...
  42. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2004
    ..Obstructed (OBS) rats exhibit urinary frequency and detrusor overactivity temporally correlated to the development of afferent ..
  43. Hospital Quality Reports for Expectant Mothers: Considering Race and Language
    Tetine Sentell; Fiscal Year: 2012
    ..We will use this information to design and test a personalized, consumer-focused website with the goal of improving the use of public hospital quality reports for pregnant women across diverse racial/ethnic and linguistic groups. ..
  44. EXPERIMENTAL LEPROSY/VACCINE STUDIES IN MANGABEYS
    Bobby Gormus; Fiscal Year: 1992
    ..Pure lymphokines will be added back to cell fractions from mangabeys with LL in attempts to reconstitute normal responses to mitogens and to D-lep...
  45. EXPERIMENTAL LEPROSY/VACCINE STUDIES IN MANGABEYS
    Bobby Gormus; Fiscal Year: 1991
    ..Pure lymphokines will be added back to cell fractions from mangabeys with LL in attempts to reconstitute normal responses to mitogens and to D-lep...
  46. C-reactive protein promotes myeloma cell-mediated bone destruction
    Qing Yi; Fiscal Year: 2010
    ..project, we will focus on the ability of CRP to promote the generation of OCs and inhibit the generation of OBs in vitro;our studies will uncover a new mechanism by which bone destruction is caused by myeloma cells, and provide ..
  47. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2006
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  48. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2007
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  49. Protective Effects of Stearic Acid on Gestational and Acquired Diabetes Mellitus
    Eric Smart; Fiscal Year: 2009
    ..This aim is critical because each double crossed mouse line will provide the definitive mechanistic data regarding the role of each protein in mediating the beneficial effects of stearic acid. ..
  50. Role of Ephrins in Osteoblast Differentiation
    M Douglas Benson; Fiscal Year: 2010
    ..Specifically:1) Ephs and ephrins are expressed in discrete layers of osteogenesis in vivo, and 2) treatment of OBs with soluble recombinant ephrin increases OB-specific gene expression and bone synthesis...
  51. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2009
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  52. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2005
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  53. Mechanisms of Innate and Acquired Host Defense and Tissue Injury in Skin
    Delphine J Lee; Fiscal Year: 2010
    ..The investigation of these aspects of host defense mechanisms will yield new insights into the human immune system as well as provide novel targets for therapeutic intervention against a variety of infectious and skin diseases. ..
  54. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2007
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  55. Predictors of Adult Leukemia
    Julie Ross; Fiscal Year: 2006
    ..to metabolize NSAIDs, detoxify environmental toxins (including pesiticides, cigarette smoke) and metabolize leptin contributes to risk...
  56. Improving Problem-Solving Performance of Students with Mathematics Difficulties
    ASHA JITENDRA; Fiscal Year: 2009
    ....
  57. Improving Problem-Solving Performance of Students with Mathematics Difficulties
    ASHA KIRON JITENDRA; Fiscal Year: 2010
    ....
  58. Regulation of Bone Formation by Ephrin B1 Signaling Pathways
    Weirong Xing; Fiscal Year: 2010
    ..on our preliminary data the following 2 hypotheses in this study: 1) disruption of ephrin B1 reverse signaling in OBs will impair OB differentiation and bone formation;2) activation of ephrin B1 mediated reverse signaling induces the ..
  59. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board
    MARY E HAPP; Fiscal Year: 2012
    ....
  60. The contribution of T cells to the anabolic activity of PTH in bone
    Jau Yi Li; Fiscal Year: 2013
    ..PTH binds to the PTH/PTH-related protein (PTHrP) receptor (PPR or PTH-1R), which is expressed on osteoblasts (OBs), osteocytes and bone marrow (BM) stromal cells (SCs)...
  61. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2003
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  62. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2010
    Maintenance of bone mass requires the integrated activity of osteoclasts (OCs) and osteoblasts (OBs)...
  63. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven Teitelbaum; Fiscal Year: 2009
    Maintenance of bone mass requires the integrated activity of osteoclasts (OCs) and osteoblasts (OBs)...
  64. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2004
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  65. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2005
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  66. Cloning of a type 2 diabetes modifier in obese mice
    Rudolph Leibel; Fiscal Year: 2006
    ..Such a gene could be used for anticipatory diagnosis and prevention, and the design of therapeutic agents. ..
  67. GENETIC ANALYSIS OF MONOCYTE KILLING BY BACTERIA
    Howard Shuman; Fiscal Year: 2005
    ..v) Determine if the coiled:coil regions of the Lep proteins are required for translocation by the Icm/Dot system and/or for their function in host cells. ..
  68. GENETIC ANALYSIS OF MONOCYTE KILLING BY BACTERIA
    Howard Shuman; Fiscal Year: 2004
    ..v) Determine if the coiled:coil regions of the Lep proteins are required for translocation by the Icm/Dot system and/or for their function in host cells. ..
  69. GENETIC ANALYSIS OF MONOCYTE KILLING BY BACTERIA
    Howard Shuman; Fiscal Year: 2006
    ..v) Determine if the coiled:coil regions of the Lep proteins are required for translocation by the Icm/Dot system and/or for their function in host cells. ..
  70. GENETIC ANALYSIS OF MONOCYTE KILLING BY BACTERIA
    Howard Shuman; Fiscal Year: 2007
    ..v) Determine if the coiled:coil regions of the Lep proteins are required for translocation by the Icm/Dot system and/or for their function in host cells. ..
  71. Computer-based Patient Provider Communication about CAM Use
    WILLIAM Z TAN; Fiscal Year: 2010
    ....
  72. SimulTel: Enabling Remote Simultaneous Medical Interpreting
    Jyotsna Changrani; Fiscal Year: 2010
    ..abstract_text> ..
  73. Computer-based Patient Provider Communication about CAM Use
    William Tan; Fiscal Year: 2009
    ....
  74. Extending Emergency Response Skills to Limited English Proficiency Communities
    Hendrika Meischke; Fiscal Year: 2010
    ....
  75. SimulTel: Enabling Remote Simultaneous Medical Interpreting
    Jyotsna Changrani; Fiscal Year: 2009
    ..abstract_text> ..
  76. Extending Emergency Response Skills to Limited English Proficiency Communities
    Hendrika Meischke; Fiscal Year: 2009
    ....
  77. Role of a TGF-B Regulated Gene in Human and Mouse Osteoblasts and Skeleton
    Thomas C Spelsberg; Fiscal Year: 2010
    ..During this laboratory's investigations of E2 and TGFb actions in OBs, we discovered and characterized the novel TGFb Inducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  78. Role of a TGF-B Regulated Gene in Human and Mouse Osteoblasts and Skeleton
    Thomas Spelsberg; Fiscal Year: 2009
    ..During this laboratory's investigations of E2 and TGFb actions in OBs, we discovered and characterized the novel TGFb Inducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  79. Role of aTGF-beta Regulated Gene in human and mouse osteoblasts and skeleton
    Thomas Spelsberg; Fiscal Year: 2007
    ..During this laboratory's investigations of estrogen (E2) and TGFb actions on OBs, we discovered and characterized the novel TGFb Iducible Early Gene-1 (TIEG) as a member of the Kruppel family of ..
  80. Computer Support for Pharmacy-Based Smoking Cessation
    FREDERICK BOCK; Fiscal Year: 2007
    ..from smokers to assess the extent of pharmacist counseling for smoking with no intervention (observation only: OBS). Pharmacists will then be trained in providing smoking cessation counseling...
  81. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2003
    ..system and tracer methods; (2) To collect real-time measurements of breath-by-breath alveolar concentrations (-700 obs.) and optimize a physiologically-based pharmacokinetic (PBPK) model for estimating of metabolism rates; (3) To ..
  82. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2005
    ..system and tracer methods; (2) To collect real-time measurements of breath-by-breath alveolar concentrations (-700 obs.) and optimize a physiologically-based pharmacokinetic (PBPK) model for estimating of metabolism rates; (3) To ..
  83. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2004
    ..system and tracer methods; (2) To collect real-time measurements of breath-by-breath alveolar concentrations (-700 obs.) and optimize a physiologically-based pharmacokinetic (PBPK) model for estimating of metabolism rates; (3) To ..
  84. Older Latina Women, Martial Status, and Cancer Screening
    Melanie Wasserman; Fiscal Year: 2007
    ..The focus for this study is on Latina women, because their use of preventive health services is particularly low. ..