LEF1

Summary

Gene Symbol: LEF1
Description: lymphoid enhancer-binding factor 1
Alias: LEF-1, TCF10, TCF1ALPHA, TCF7L3, T cell-specific transcription factor 1-alpha, TCF1-alpha
Species: human

Top Publications

  1. ncbi The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing
    K Hovanes
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697 4025, USA
    Nucleic Acids Res 28:1994-2003. 2000
  2. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  3. ncbi LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
  4. ncbi Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition
    J Y Lee
    Department of Pathology, College of Medicine, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
    Oncogene 28:824-31. 2009
  5. ncbi LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
  6. ncbi ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
    L Bruhn
    Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Genes Dev 11:640-53. 1997
  7. ncbi Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
  8. ncbi Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo
    Tim Willinger
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
    J Immunol 176:1439-46. 2006
  9. ncbi Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    Kwonseop Kim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Biol Int 26:463-76. 2002
  10. ncbi Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 277:28787-94. 2002

Research Grants

  1. Msx2 function in tooth crown morphogenesis
    Marianna Bei; Fiscal Year: 2007
  2. The Genetic Basis of Human Tooth Agenesis
    Sylvia Frazier Bowers; Fiscal Year: 2006
  3. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael McDaniel; Fiscal Year: 2009
  4. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2010
  5. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2010
  6. TGF BETA SIGNALING AND MANDIBULAR MORPHOGENESIS
    Yang Chai; Fiscal Year: 2003
  7. Endogenous retinoids in mammalian skin and hair function
    HELEN EVERTS; Fiscal Year: 2007
  8. Endogenous retinoids in mammalian skin and hair function
    HELEN EVERTS; Fiscal Year: 2007
  9. Regulation of Wnt Signaling by PAP2b During Angiogenesis
    Kishore Wary; Fiscal Year: 2009
  10. Regulation of Wnt Signaling by PAP2b During Angiogenesis
    Kishore K Wary; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications172 found, 100 shown here

  1. ncbi The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing
    K Hovanes
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697 4025, USA
    Nucleic Acids Res 28:1994-2003. 2000
    ..The promoter is most active in a B lymphocyte cell line (Raji) in which the endogenous LEF-1 gene is silent, suggesting that the promoter region is actively repressed by a silencing mechanism...
  2. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
  3. ncbi LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
    ..Furthermore, we found that IL-4 stimulation possesses a negative effect on the expressions of LEF-1 and TCF-1 in primary T cells, suggesting a positive feedback effect of IL-4 on IL4 gene expression...
  4. ncbi Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition
    J Y Lee
    Department of Pathology, College of Medicine, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
    Oncogene 28:824-31. 2009
    ....
  5. ncbi LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
    ..These observations indicate that LEF-1 is an instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in individuals with CN...
  6. ncbi ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
    L Bruhn
    Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Genes Dev 11:640-53. 1997
    ..We propose that ALY mediates context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR alpha enhancer complex...
  7. ncbi Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
    ..This study therefore suggests that the MITF/TFE3 family is a new class of nuclear modulators for LEF-1, which may ensure efficient propagation of Wnt signals in many types of cells...
  8. ncbi Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo
    Tim Willinger
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
    J Immunol 176:1439-46. 2006
    The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in ..
  9. ncbi Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    Kwonseop Kim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Biol Int 26:463-76. 2002
    ..Normal adult epithelial cells appear to use APC to keep beta-catenin out of the nucleus, thereby avoiding pathologies such as metastases due to LEF/beta-catenin-induced EMT...
  10. ncbi Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 277:28787-94. 2002
    ..of the M promoter was detected with MITF-M alone or with the combination of MITF-M and dominant-negative LEF1 that lacks the beta-catenin-binding domain...
  11. ncbi PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
    S Sachdev
    Gene Center and Institute of Biochemistry, University of Munich, 81377 Munich, Germany
    Genes Dev 15:3088-103. 2001
    The Wnt-responsive transcription factor LEF1 can activate transcription in association with beta-catenin and repress transcription in association with Groucho...
  12. ncbi Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas
    Christina Spaulding
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Blood 110:2650-8. 2007
    ..Here, we report that expression of the transcription factor lymphoid enhancer factor 1 (Lef1) is Notch dependent in murine T-cell lymphomas in vitro and in vivo, and that the intracellular domain of Notch1 (..
  13. ncbi The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    Jose Sierra
    Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:586-600. 2006
    ..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells...
  14. ncbi Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity
    Kelly A Holmes
    Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
    Cancer Res 68:7380-5. 2008
    ..These data provide insight into the role of Nkx3-1 and LEF-1 as potential regulators of the hormone response in breast cancer...
  15. ncbi Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Blood 114:3044-51. 2009
    ..ELA2 gene promoter is positively regulated by the direct binding of LEF-1 or C/EBPalpha, documenting the role of LEF1 in the diminished ELA2 expression...
  16. ncbi Lef-1 isoforms regulate different target genes and reduce cellular adhesion
    Sarah Jesse
    Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
    Int J Cancer 126:1109-20. 2010
    ..Our findings indicate that expression of alternatively spliced Lef-1 isoforms is involved in the determination of proliferative or migratory characteristics of pancreatic carcinoma cells...
  17. ncbi The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription
    Diego Navarro
    Departamento de Biología del Cáncer, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, E 28029, Madrid, Spain
    Carcinogenesis 31:394-401. 2010
    ..Our results show that EWS/FLI1 inhibits both DKK-1 expression as well as beta-catenin/TCF-dependent transcription, which could contribute to progression of tumours of the Ewing family...
  18. ncbi Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression
    Diego A Rodriguez
    Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugia, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 20:2297-310. 2009
    ....
  19. ncbi LEF-1 is a decisive transcription factor in neutrophil granulopoiesis
    Julia Skokowa
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Ann N Y Acad Sci 1106:143-51. 2007
    ..In summary we demonstrated that LEF-1 is not only crucial in lymphopoiesis, but also in myelopoiesis, documenting new functions of LEF-1...
  20. ncbi LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis
    Albert Gutierrez
    Department of Immunology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Blood 116:2975-83. 2010
    ..aberrant expression of the Wnt pathway transcription factor and target gene lymphoid enhancer binding factor-1 (LEF1) in chronic lymphocytic leukemia (CLL)...
  21. ncbi Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305 5126, USA
    Nat Struct Mol Biol 12:364-71. 2005
    ....
  22. ncbi PITX2 and beta-catenin interactions regulate Lef-1 isoform expression
    Melanie Amen
    Texas A and M Health Science Center, Institute of Biosciences and Technology, 2121 W Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biol 27:7560-73. 2007
    ..These data support a role for PITX2 in cell proliferation, migration, and cell division through differential Lef-1 isoform expression and interactions with Lef-1 and beta-catenin...
  23. ncbi Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis
    Ryan R Driskell
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L752-63. 2004
    ..These findings suggest that Wnt regulation of the Lef-1 promoter at the WRE may play an important role during airway submucosal glandular bud formation...
  24. ncbi Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
    A V Tutter
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 15:3342-54. 2001
    ..We conclude that the CT-ARM region of beta-catenin functions as a chromatin-specific activation domain, and that several inhibitors of the Wnt/Wg pathway directly modulate LEF-1-beta-cat activity on chromatin...
  25. ncbi Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription
    Mohamed El-Tanani
    Department of Surgery, Cancer Research Centre, Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, N Ireland, UK
    J Biol Chem 279:20794-806. 2004
    ..These results suggest that the presence of these transcription factors in human breast cancer is responsible in part for the overexpression of OPN that, in turn, is implicated in mammary neoplastic progression and metastasis...
  26. ncbi Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:227-33. 2003
    ..Apoptosis induction by wild-type NLK was confirmed using TUNEL assays. Our results suggest that overexpression of NLK may have targets other than TCF for induction of apoptosis in human colon carcinoma cells...
  27. ncbi Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling
    S Kyun Lim
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:18580-5. 2006
    ..tumor-derived mutant Smad4 proteins that fail to mediate TGF-beta responses were still competent to cooperate with LEF1 to activate the c-myc promoter...
  28. ncbi LEF-1 activates the transcription of E2F1
    Fangfang Zhou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 365:149-53. 2008
    ....
  29. ncbi Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis
    Maralice E Conacci-Sorrell
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 16:2058-72. 2002
    ..The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility...
  30. ncbi Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter
    Mohammed Filali
    Department of Anatomy and Cell Biology and the Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 277:33398-410. 2002
    ..In summary, these results provide evidence for transcriptional regulation of the LEF-1 promoter by Wnt and enhance the mechanistic understanding of Wnt/beta-catenin signaling in the regulation of LEF-1-dependent developmental processes...
  31. ncbi A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis
    Konstantin Petropoulos
    Department of Medicine III, Klinikum Grosshadern, D 81377 Munich, Germany
    J Exp Med 205:515-22. 2008
    ..These data indicate a thus far unknown role of Lef-1 in the biology of acute leukemia, pointing to the necessity of balanced Lef-1 expression for an ordered hematopoietic development...
  32. ncbi The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins
    M G Prieve
    Department of Microbiology and Molecular Genetics, University of California, Irvine, 92717 4025, USA
    J Biol Chem 271:7654-8. 1996
    ..We find a surprising and significant difference in the expression pattern of pendulin and mSrp1 mRNA, suggesting that these two Srp1 proteins are distinguishable in function as well as sequence...
  33. ncbi Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1
    M G Prieve
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California 92697 4025, USA
    Mol Cell Biol 18:4819-32. 1998
    ..GFP-LEF-1 readily localizes to the nucleus, whereas GFP-TCF-1 remains in the cytoplasm. Thus, LEF-1 and TCF-1 differ in several aspects of nuclear localization...
  34. ncbi Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
    LAURA ARCE
    Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697 4025, USA
    BMC Cancer 9:159. 2009
    ..The molecular events involved in this competitive interaction are not defined and the actions of Groucho/TLEs within the context of Wnt-linked cancer are unknown...
  35. ncbi Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD
    Brandon Beagle
    Department of Anesthesiology and Pharmacology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 5:e11821. 2010
    ..These results suggest that LRP6-ICD can differentially modulate Wnt pathway transcriptional activity depending upon its subcellular localization and differential protein-protein interactions...
  36. ncbi Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    P Zhou
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Genes Dev 9:700-13. 1995
    ..Collectively, our findings demonstrate that ectodermal expression of LEF-1 plays a central role in gene expression, pattern formation, and other developmental processes involving epithelial-mesenchymal associations...
  37. ncbi Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
    E T Strovel
    Division of Human Genetics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 275:2399-403. 2000
    ..PP2C utilizes Axin as a substrate both in vitro and in vivo and decreases its half-life. These results indicate that PP2C is a positive regulator of Wnt signal transduction and mediates its effects through the dephosphorylation of Axin...
  38. ncbi Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    D Levanon
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:11590-5. 1998
    ..These data indicate that, in addition to their activity as transcriptional activators, AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling...
  39. ncbi Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    E Labbe
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Proc Natl Acad Sci U S A 97:8358-63. 2000
    ..by the DNA-binding HMG box transcription factors lymphoid enhancer binding factor 1/T cell-specific factor (LEF1/TCF) and their coactivator beta-catenin...
  40. ncbi LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
    A Travis
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Genes Dev 5:880-94. 1991
    ..Moreover, forced expression of recombinant LEF-1 in late stage B cells increases TCR alpha enhancer function. Taken together, these data suggest that LEF-1 is a regulatory participant in lymphocyte gene expression and differentiation...
  41. ncbi Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    Rachel A Kahler
    University of Minnesota Cancer Center, Department of Orthopaedic Surgery and Graduate Program in Microbiology, Immunology and Cancer Biology, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:11937-44. 2003
    ..A functional binding site for the high mobility group protein lymphoid enhancer-binding factor 1 (LEF1) was found adjacent to the proximal Runx2-binding site in the osteocalcin promoter...
  42. ncbi Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling
    Tohru Ishitani
    Department of Molecular Biology, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa ku, Nagoya 464 8602, Japan
    Mol Cell Biol 23:1379-89. 2003
    ..These results suggest that NLK phosphorylation on these sites contributes to the down-regulation of LEF-1/TCF transcriptional activity...
  43. ncbi Wnt activation and alternative promoter repression of LEF1 in colon cancer
    Tony W H Li
    Department of Microbiology and Molecular Genetics, Rm B240, Medical Sciences I, University of California, Irvine, Irvine, CA 92697 4025, USA
    Mol Cell Biol 26:5284-99. 2006
    Alternative promoters within the LEF1 locus produce polypeptides of opposing biological activities. Promoter 1 produces full-length LEF-1 protein, which recruits beta-catenin to Wnt target genes...
  44. ncbi Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4
    Andreas Hecht
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108 Freiburg, Germany
    J Biol Chem 278:3776-85. 2003
    ..We found that TCF4E but not LEF1 supported beta-catenin-dependent activation of the Cdx1 promoter, whereas LEF1 specifically activated the Siamois ..
  45. ncbi A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
    M Brannon
    Department of Biochemistry, University of Washington School of Medicine, Seattle 98195 7350, USA
    Genes Dev 11:2359-70. 1997
    ....
  46. ncbi Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
    C van Genderen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Genes Dev 8:2691-703. 1994
    ..Together, the pattern of these defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions...
  47. ncbi NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)
    Misato Yamada
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, JST, Chiyoda ku, Japan
    J Biol Chem 281:20749-60. 2006
    ..Collectively, our findings raise the possibility that NARF functions as a novel ubiquitin-ligase to suppress the Wnt-beta-catenin signaling...
  48. ncbi All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    H Brantjes
    Department of Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 29:1410-9. 2001
    ..Although Grg-5 contains the GP homology domain that mediates HDAC binding in long Grg proteins, Grg-5 fails to bind this co-repressor, explaining how it can de-repress transcription...
  49. ncbi A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer
    M L Waterman
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037
    Genes Dev 5:656-69. 1991
    ..TCF-1 alpha is currently unique among the newly emerging family of DNA-binding regulatory proteins that share the HMG motif in that it is a highly tissue-specific RNA polymerase II transcription factor...
  50. ncbi Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
    K Hovanes
    Microbiology and Molecular Genetics Department, University of California, Irvine, Irvine, California, USA
    Nat Genet 28:53-7. 2001
    ..allowing it to accumulate in the nucleus and form complexes with any member of the lymphoid enhancer factor (LEF1) and T-cell factor (TCF1, TCF3, TCF4) family of transcription factors (referred to collectively as LEF/TCFs) to ..
  51. ncbi The notch intracellular domain can function as a coactivator for LEF-1
    D A Ross
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6145, USA
    Mol Cell Biol 21:7537-44. 2001
    ..Our data therefore describe a new nuclear target of Notch signaling and a new coactivator for LEF-1...
  52. ncbi LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion
    Yirong Li
    Department of Pathology, New York University School of Medicine, NY 10010, USA
    Cancer Res 69:3332-8. 2009
    ..In this study, we examined LEF1 expression in androgen-independent cancer as well as its regulation of androgen receptor (AR) expression, prostate ..
  53. ncbi Alterations of lymphoid enhancer factor-1 isoform expression in solid tumors and acute leukemias
    Wenbing Wang
    Institute of Life Sciences, Jiangsu University, Zhenjiang, China
    Acta Biochim Biophys Sin (Shanghai) 37:173-80. 2005
    ..Taken together, these data suggest that LEF-1 is abundantly expressed in human tumors and the ratio of the oncogenic and the dominant negative short isoform altered not only in carcinomas but also in leukemia...
  54. ncbi Gene-expression profiles of a hepatitis B small surface antigen-secreting cell line reveal upregulation of lymphoid enhancer-binding factor 1
    Xiaochen Tian
    Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai, China
    J Gen Virol 88:2966-76. 2007
    ....
  55. ncbi Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
    M van de Wetering
    Department of Clinical Immunology, University Hospital Utrecht, The Netherlands
    EMBO J 10:123-32. 1991
    ..These results identify TCF-1 as a T cell-specific transcription factor, which might play a role in the establishment of the mature T cell phenotype...
  56. ncbi An internal ribosome entry site mediates translation of lymphoid enhancer factor-1
    Judith Jimenez
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, CA 92697 4025, USA
    RNA 11:1385-99. 2005
    The lymphoid enhancer factor-1 LEF1 locus produces multiple mRNAs via alternative promoters. Full-length LEF-1 protein is produced via translation of an mRNA with a 1...
  57. ncbi PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter
    Usha Vadlamudi
    Department of Biological Science, The University of Tulsa, 600 S College Ave, Tulsa, OK 74104 3189, USA
    J Cell Sci 118:1129-37. 2005
    ..LEF-1 and beta-catenin interactions with PITX2 provide new mechanisms for the regulation of PITX2 transcriptional activity...
  58. ncbi E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription
    Vicente A Torres
    FONDAP Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Santiago, Chile
    Mol Cell Biol 27:7703-17. 2007
    ..Thus, the absence of E-cadherin severely compromises the ability of caveolin-1 to develop activities potentially relevant to its role as a tumor suppressor...
  59. ncbi Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin
    Xiaoming Liu
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242 1109, USA
    J Invest Dermatol 123:264-74. 2004
    ..In summary, these studies have begun to dissect the transcriptional diversity of the human Lef-1 promoter during the hair/vibrissa follicle and sebaceous gland formation...
  60. ncbi Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
    A N Billin
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112 5550, USA
    Mol Cell Biol 20:6882-90. 2000
    ..We show here that repression by LEF1 requires histone deacetylase (HDAC) activity...
  61. ncbi Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
    A Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, Goldensen Bldg, Room 342, Boston, MA 02115, USA
    Arch Oral Biol 49:675-89. 2004
    ..Because TGFbeta3 and its downstream target, LEF1, play the major role in epithelial transformation, it is important to identify the signalling pathways they use for ..
  62. ncbi Msx1 controls inductive signaling in mammalian tooth morphogenesis
    Y Chen
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:3035-44. 1996
    ..Our results show that expression of Bone Morphogenetic Protein 4 (BMP4), the HMG box gene Lef1 and the heparan sulfate proteoglycan syndecan-1 is specifically reduced in Msx1 mutant dental mesenchyme, while ..
  63. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..However, the enamel knot, a putative organizer of crown formation, is present and expresses Fgf4, Wnt10b, Bmp2 and Lef1, as in the wild type...
  64. ncbi LEF1 is a critical epithelial survival factor during tooth morphogenesis
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 278:130-43. 2005
    b>LEF1 is a cell-type-specific transcription factor and mediates Wnt signaling pathway by association with its co-activator beta-catenin...
  65. ncbi Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex
    Uladzislau Ivaniutsin
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Neural Dev 4:3. 2009
    ..We examined the consequences of loss of Apc function for the early development of the cerebral cortex...
  66. ncbi Severe congenital neutropenia: inheritance and pathophysiology
    Julia Skokowa
    Department of Pediatric Hematology Oncology, Medical University Hannover, Hannover, Germany
    Curr Opin Hematol 14:22-8. 2007
    ..5 x 10/l. In this review we summarize our current knowledge on inheritance and pathophysiolgy of congenital neutropenia...
  67. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  68. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..b>Lef1/Tcf1-dependent Wnt signaling is not essential for initiation of Tbx5 or Fgf10 transcription, but is required in ..
  69. ncbi Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Biocenter 1, University of Helsinki, P O Box 56, Helsinki, FIN 00014, Finland
    Dev Genes Evol 209:495-506. 1999
    ..tooth germs we compared the expression patterns of several developmental regulatory genes (Bmp2, Bmp4, Fgf4, Fgf8, Lef1, Msx1, Msx2, p21, Pitx2, Pax9 and Shh) between molars and diastema buds of mice and voles...
  70. ncbi TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
    ..Moreover, ectodysplasin expression was downregulated in branchial arch epithelium and in tooth germs of Lef1 mutant mice, suggesting that signaling by ectodysplasin is regulated by LEF-1-mediated Wnt signals...
  71. ncbi Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria
    Lidia Hernandez
    Cancer and Developmental Biology Laboratory, NCI, Frederick, MD 21702, USA
    Dev Cell 19:413-25. 2010
    ..with inhibition of canonical Wnt signaling, due to reduced nuclear localization and transcriptional activity of Lef1, but not Tcf4, in both mouse and human progeric cells...
  72. ncbi Lymphocyte enhancer-binding factor 1: an essential factor in odontoblastic differentiation of dental pulp cells enzymatically isolated from rat incisors
    Satoshi Yokose
    Division of Operative Dentistry, Department of Conservative Dentistry, School of Dentistry, Ohu University, 31 1 Misumido, Tomitamachi, Koriyama, Fukushima, Japan
    J Bone Miner Metab 28:650-8. 2010
    Lymphocyte enhancer-binding factor 1 (Lef1), a HMG-domain protein, is thought to play important roles in inductive tissue interaction during tooth development. Lef1 knockdown in mice causes arrest at the bud stage in tooth development...
  73. ncbi The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer
    M N Laurent
    Department of Developmental and Cell Biology, and the Developmental Biology Center, University of California, Irvine 92697 2300, USA
    Development 124:4905-16. 1997
    ..First, we demonstrate that purified LEF1 protein can interact, in vitro, with consensus LEF1/TCF3-binding sites found within the Xtwn promoter...
  74. ncbi Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1
    Jun Ichi Hanai
    Divisions of Nephrology and Hematology Oncology, Department of Medicine and Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:16464-9. 2002
    ..Using a series of deletion and mutant promoter constructs, we identified the LEF1 site in the cyclin D1 promoter as essential for the inhibitory effect of endostatin...
  75. ncbi Estradiol activates beta-catenin dependent transcription in neurons
    Olga Varea
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED and Centro de Biología Molecular Severo Ochoa, CSIC UAM, Madrid, Spain
    PLoS ONE 4:e5153. 2009
    ..These findings may reveal a set of new physiological roles for estrogens, at least in the Central Nervous System (CNS)...
  76. ncbi Different roles of Runx2 during early neural crest-derived bone and tooth development
    Martyn J James
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Bone Miner Res 21:1034-44. 2006
    ..In vitro experiments determined that Runx2 is a part of the FGF and BMP signaling pathways in tooth and bone development, respectively...
  77. ncbi Expressional changes in the intracellular melanogenesis pathways and their possible role in the pathogenesis of vitiligo
    Külli Kingo
    Department of Dermatology and Venerology, Centre of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia
    J Dermatol Sci 52:39-46. 2008
    ..In our previous study we established significant increase of melanocortin receptor expression in unaffected skin of vitiligo patients compared to healthy subjects...
  78. ncbi Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment
    Gerard Sutton
    Save Sight Institute, Sydney Medical School, New South Wales, Australia
    Clin Experiment Ophthalmol 38:43-8. 2010
    ..To investigate the expression of Wnt signalling pathway genes in keratoconic (KC) epithelium...
  79. ncbi Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression
    Tinchung Leung
    Developmental Biology, Institute Biology 1, University of Freiburg, Freiburg, Germany
    Dev Dyn 228:424-32. 2003
    ..We further identify high-affinity binding sites for Tcf/Lef1 within the boz promoter region...
  80. ncbi Comparative genomics on FGF16 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:959-63. 2005
    ..Because nuclear complex consisting of TCF/LEF (TCF1, TCF3, TCF4 or LEF1), beta-catenin, PYGO (PYGO1 or PYGO2) and Legless (BCL9 or BCL9L) binds to the TCF/LEF-binding site to up-regulate ..
  81. ncbi OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling
    Michael E Feigin
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, United States
    Cell Signal 20:949-57. 2008
    ..of wild-type OSTM1 stimulated whereas mutant OSTM1 inhibited, the Wnt-dependent association of beta-catenin and Lef1. On the foundation of these experiments, we propose that the human mutations in OSTM1 such as the C-terminal ..
  82. ncbi Down-regulated genes in mouse dental papillae and pulp
    H Sasaki
    Oral Health Science Center HRC7, Tokyo Dental College, Japan
    J Dent Res 89:679-83. 2010
    ..Drastic down-regulation (fold change > 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression (..
  83. ncbi The Groucho/TLE/Grg family of transcriptional co-repressors
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, Lincoln s Inn Fields, London, WC2A 3PX, UK
    Genome Biol 9:205. 2008
    ..directly, but are recruited by a diverse profile of transcription factors, including members of the Hes, Runx, Nkx, LEF1/Tcf, Pax, Six and c-Myc families...
  84. ncbi Regulation of casein kinase I epsilon activity by Wnt signaling
    Wojciech Swiatek
    Department of Oncological Sciences and the Center for Children, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    J Biol Chem 279:13011-7. 2004
    ..biologically relevant because CKIepsilon(MM2) is more effective than CKIepsilon at activating transcription from a Lef1-dependent promoter...
  85. ncbi Nmp4/CIZ: road block at the intersection of PTH and load
    Paul Childress
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 46:259-66. 2010
    ..The p130Cas/zyxin/Nmp4/CIZ pathway resembles the beta-catenin/TCF/LEF1 mechanotransduction response limb and both share features with the HMGB1 (high mobility group box 1)/RAGE (receptor ..
  86. ncbi Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes
    Satu Kuure
    Biochemistry and Developmental Biology, Institute of Biomedicine, PO Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
    J Am Soc Nephrol 18:1130-9. 2007
    ..signaling cascades downstream of GSK3 inhibition revealed stabilization of beta-catenin and upregulation of Lef1 and Tcf1, both events that are associated with the active canonical Wnt signaling...
  87. ncbi Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor
    Yu Feng Dong
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 208:77-86. 2006
    ..Co-transfection of lymphoid enhancer factor (Lef1) and beta-catenin in chicken upper sternal chondrocytes together with deletion constructs of the Runx2 promoter ..
  88. ncbi Expression of Wnt5a in tooth germs and the related signal transduction analysis
    L Peng
    West China Hospital of Stomatology, China
    Arch Oral Biol 55:108-14. 2010
    ..This study investigates its expression mode in human tooth development and the involved cell signal transduction pathways, as they remain unclear...
  89. ncbi Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation
    Gemma Martinez
    Ocular Development Laboratory, Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 50:4794-806. 2009
    ..In this study, the consequences of constitutively activating the pathway in lens during development were investigated...
  90. ncbi Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland
    Kata Boras-Granic
    Department of Laboratory Medicine and Pathobiology, 6318 Medical Sciences Building, 1 King s College Road, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Biol 295:219-31. 2006
    ..b>Lef1-mediated canonical Wnt signaling is required for morphogenesis of these skin appendages during embryogenesis...
  91. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
    ..mice, TOPGAL expression was directly stimulated by a stabilized form of beta -catenin, but was also dependent upon LEF1/TCF3 in skin...
  92. ncbi Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Anat 205:1-13. 2004
    ..is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1, encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in ..
  93. ncbi Wnt2b controls retinal cell differentiation at the ciliary marginal zone
    Fumi Kubo
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Kyoto 606 8502, Japan
    Development 130:587-98. 2003
    ..b>LEF1, a downstream Wnt signaling component, was expressed at high levels in the ciliary marginal zone with expression ..
  94. ncbi Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis
    Muhammad Abu-Elmagd
    University of East Anglia, School of Biological Sciences, Norwich, NR4 7TJ Earlham Road, UK
    Dev Biol 337:211-9. 2010
    ..We now show that Wnt signaling via Lef1 acts to regulate the number of premyogenic cells in somites but does not regulate myogenic initiation in the limb ..
  95. ncbi E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression
    Guiomar Solanas
    Unitat de Biofísica CEB, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    J Cell Sci 121:2224-34. 2008
    ..of E-cadherin and the upregulation of expression of mesenchymal genes such as those encoding fibronectin and LEF1. We studied the molecular mechanism controlling the expression of these genes in mesenchymal cells...
  96. ncbi Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
    B J Merrill
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:1688-705. 2001
    ..In this paper, we show that Tcf3 and Lef1 control these differentiation lineages...
  97. ncbi On the regulation of hair keratin expression: lessons from studies in pilomatricomas
    Bernard Cribier
    Clinique Dermatologique, Hopital Civil, Strasbourg, France
    J Invest Dermatol 122:1078-83. 2004
    ..In contrast, the nuclear co-expression of LEF1 and beta-catenin, which in the hair follicle has been postulated to initiate cortex cell differentiation through ..
  98. ncbi Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
    Melanie Konigshoff
    Department of Medicine, University of Giessen Lung Center, University of Giessen, Giessen, Germany
    PLoS ONE 3:e2142. 2008
    ..Thus, we quantified and localized the expression and activity of the Wnt/beta-catenin pathway in IPF...
  99. ncbi Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex
    Tomomi Shimogori
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Comp Neurol 473:496-510. 2004
    ..The penultimate components of the canonical Wnt pathway are the Tcf/Lef1 transcription factors, which regulate transcription of Wnt signaling target genes...
  100. ncbi Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis
    C Niemann
    Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Proc Natl Acad Sci U S A 100:11873-80. 2003
    ..of beta-catenin leads to formation of hair follicle tumors, whereas overexpression of N-terminally truncated Lef1, which blocks beta-catenin signaling, results in spontaneous sebaceous tumors...
  101. ncbi Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
    ..The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however.

Research Grants64

  1. Msx2 function in tooth crown morphogenesis
    Marianna Bei; Fiscal Year: 2007
    ..WNTs and transforming growth factor b (TGFb) superfamilies as well as mediators of signaling such as p21, Edar, Lef1 and Msx2. Mice lacking the homeobox gene Msx2 exhibit defects in crown morphogenesis...
  2. The Genetic Basis of Human Tooth Agenesis
    Sylvia Frazier Bowers; Fiscal Year: 2006
    ..two genes are responsible for the majority of cases of molar oligodontia, or if other key candidate genes such as LEF1, or BMP4 are responsible in some cases...
  3. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael McDaniel; Fiscal Year: 2009
    ..Using isolated islets, we will utilize siRNA of GSK-3, -catenin & mTOR, study Wnt- dependent TCF/LEF1 transcription using transgenic TOPGAL mice & evaluate GF signaling and GSK-3 activity after chronic nutrient or ..
  4. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2010
    ..Using isolated islets, we will utilize siRNA of GSK-3, -catenin &mTOR, study Wnt- dependent TCF/LEF1 transcription using transgenic TOPGAL mice &evaluate GF signaling and GSK-3 activity after chronic nutrient or ..
  5. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2010
    ..Using isolated islets, we will utilize siRNA of GSK-3, -catenin &mTOR, study Wnt- dependent TCF/LEF1 transcription using transgenic TOPGAL mice &evaluate GF signaling and GSK-3 activity after chronic nutrient or ..
  6. TGF BETA SIGNALING AND MANDIBULAR MORPHOGENESIS
    Yang Chai; Fiscal Year: 2003
    ..by TGF-beta is mediated by an intracellular signaling pathway that down regulates transcription factor Lef1. Three Specific Aims are designed to test the hypotheses: (1) to determine and compare the temporal and spatial ..
  7. Endogenous retinoids in mammalian skin and hair function
    HELEN EVERTS; Fiscal Year: 2007
    ..The Lef1/Tcf transgenic mouse model (Tg(Fos-lacZ)34Efu/J; aka TOPGAL) will be treated with retinoids/inhibitors to determine ..
  8. Endogenous retinoids in mammalian skin and hair function
    HELEN EVERTS; Fiscal Year: 2007
    ..The Lef1/Tcf transgenic mouse model (Tg(Fos-lacZ)34Efu/J; aka TOPGAL) will be treated with retinoids/inhibitors to determine ..
  9. Regulation of Wnt Signaling by PAP2b During Angiogenesis
    Kishore Wary; Fiscal Year: 2009
    ..Together, these studies are expected to reveal a new target for anti-angiogenic molecular therapy. ..
  10. Regulation of Wnt Signaling by PAP2b During Angiogenesis
    Kishore K Wary; Fiscal Year: 2010
    ..Together, these studies are expected to reveal a new target for anti-angiogenic molecular therapy. ..
  11. INHIBITION OF HIV GENE TRANSCRIPTION BY SMALL MOLECULES
    JOEL GOTTESFELD; Fiscal Year: 2000
    ..region of the HIV LTR and, specifically, to the sequences flanking and including the binding sites for Ets-1, LEF1 and NF-kB transcription factors and the region immediately flanking the TATA box element upstream from the ..
  12. REGULATION OF EPIDERMAL DEVELOPMENT AND DIFFERENTIATION
    Elaine Fuchs; Fiscal Year: 2009
    ..A final Wnt signal is transmitted when stem cell progeny, called matrix (Mx; Lef 1+) cells, are instructed to make the hair shaft rather than its channel (IRS)...
  13. REGULATION OF EPIDERMAL DEVELOPMENT AND DIFFERENTIATION
    Elaine Fuchs; Fiscal Year: 2010
    ..A final Wnt signal is transmitted when stem cell progeny, called matrix (Mx;Lef 1+) cells, are instructed to make the hair shaft rather than its channel (IRS)...
  14. REGULATION OF EPIDERMAL DEVELOPMENT AND DIFFERENTIATION
    Elaine Fuchs; Fiscal Year: 2007
    ..A final Wnt signal is transmitted when stem cell progeny, called matrix (Mx; Lef 1+) cells, are instructed to make the hair shaft rather than its channel (IRS)...
  15. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004
    ..2B): Hypothesis: Misexpression of LEF1 inhibits the activation of specific genes that are necessary for subsequent normal cardiac morphogenetic processes ..
  16. Integration of Signaling Pathways Regulating Chondrocyte Differentiation
    SHERRILL ADAMS; Fiscal Year: 2009
    ..multiple transcription factors, including RA receptors, Runx2, an Ets family member and two DNA-bending factors, Lef1 and AP1...
  17. Integration of Signaling Pathways Regulating Chondrocyte Differentiation
    Sherrill L Adams; Fiscal Year: 2010
    ..multiple transcription factors, including RA receptors, Runx2, an Ets family member and two DNA-bending factors, Lef1 and AP1...
  18. TGFbeta3 SIGNALING IN DEVELOPMENT OF PALATE
    Ali Nawshad; Fiscal Year: 2010
    ..Smad dependent and Smad independent pathways to activate many transcription factors such as Snail, Slug, SIP1 and LEF1. It is unclear how these pathways and activated transcription factors promote cell cycle arrest, cell migration and ..
  19. Wnt Signaling in IBD-Related Colon Cancer
    RANDALL HOLCOMBE; Fiscal Year: 2005
    ..by nuclearization of beta-catenin and increased expression and activity of a downstream pathway component, LEF1. Finally, the role of specific Fz receptor subtypes in the initiation and propagation of Wnt pathway signals will ..
  20. The Role of Proteinases and Vascular Lesion Formation
    Michael Reidy; Fiscal Year: 2006
    ..We will also measure activation of a beta-catenin/ LEF1 reporter construct in wild type and MMP-9 -/- cells since this is known to upregulate cyclin D1 expression...
  21. ROLE OF KAISO IN METASTASIS
    Albert Reynolds; Fiscal Year: 2004
    ..suggests that this protein complex may be involved in a signal pathway analogous to that associated with b-catenin-Lef1/TCF that figures prominently in the progression of melanoma and colon carcinoma...