Gene Symbol: LDB3
Description: LIM domain binding 3
Alias: CMD1C, CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP, LIM domain-binding protein 3, PDZ and LIM domain 6, Z-band alternatively spliced PDZ-motif protein, cardiomyopathy, dilated 1C (autosomal dominant), protein cypher
Species: human
Products:     LDB3

Top Publications

  1. Haddad N, Mahmud Batainh A, Suleiman Migdadi O, Saini D, Krishnamurthy V, Parameswaran S, et al. Next generation sequencing of Apis mellifera syriaca identifies genes for Varroa resistance and beneficial bee keeping traits. Insect Sci. 2016;23:579-90 pubmed publisher
    ..have identified immune related embryonic development (Cactus, Relish, dorsal, Ank2, baz), Varroa hygiene (NorpA2, Zasp, LanA, gasp, impl3) and Varroa resistance (Pug, pcmt, elk, elf3-s10, Dscam2, Dhc64C, gro, futsch) functional ..
  2. van Huis A. Cultural significance of termites in sub-Saharan Africa. J Ethnobiol Ethnomed. 2017;13:8 pubmed publisher
    ..Termites also play a role as oracle, in superstitious beliefs, in art and literature...
  3. Lopez Ayala J, Pastor Quirante F, González Carrillo J, Lopez Cuenca D, Sanchez Munoz J, Oliva Sandoval M, et al. Genetics of myocarditis in arrhythmogenic right ventricular dysplasia. Heart Rhythm. 2015;12:766-73 pubmed publisher
    ..Myocarditis clustered in families bearing DSP Q447* and LDB3 c.1051A>G...
  4. Dixon D, Choi J, El Ghazali A, Park S, Roos K, Jordan M, et al. Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015;5:9042 pubmed publisher
    ..and function, Trim55, Mapt, Pdlim3, Pdlim5, Sorbs1, Sorbs2, Fhod1, Spag9 and structural components of the sarcomere, Myom1, Tnnt2, Zasp. Thus this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.
  5. Weeland C, van den Hoogenhof M, Beqqali A, Creemers E. Insights into alternative splicing of sarcomeric genes in the heart. J Mol Cell Cardiol. 2015;81:107-13 pubmed publisher
    ..Through various examples (titin, myomesin, troponin T, tropomyosin and LDB3) we illustrate how alternative splicing regulates the functional properties of the sarcomere...
  6. Jensen L, Thayssen P, Christiansen E, Maeng M, Ravkilde J, Hansen K, et al. Safety and Efficacy of Everolimus- Versus Sirolimus-Eluting Stents: 5-Year Results From SORT OUT IV. J Am Coll Cardiol. 2016;67:751-62 pubmed publisher
    ..Randomized Clinical Comparison of the Xience V and the Cypher Coronary Stents in Non-selected Patients With Coronary Heart Disease [SORT OUT IV]; NCT00552877).
  7. Gerard D, Ferrão L, Garcia A, Stephens M. Genotyping Polyploids from Messy Sequencing Data. Genetics. 2018;210:789-807 pubmed publisher
    ..iv) We derive oracle genotyping error rates that may be used for read depth suggestions...
  8. Ding J, Peng Z, Wu D, Miao J, Liu B, Wang L. A transcriptomics study of differentiated C2C12 myoblasts identified novel functional responses to 17β-estradiol. Cell Biol Int. 2018;42:965-974 pubmed publisher
    ..by E2 were identified, and RT-qPCR validation results showed seven cytoskeletal genes (Myh8, Cenpe, Jak3, Obscn, Ldb3, Mybpc2, Col4a3bp), three genes related to ion channels (Kcnq1, Lrrc26, P2rx3) and Fhl1 transcript 2 were ..
  9. Courtwright A, Gabriel P. Clinical Databases for Chest Physicians. Chest. 2018;153:1016-1022 pubmed publisher
    ..technical platforms, including Microsoft Excel and Access, relational database management systems such as Oracle and PostgreSQL, and Research Electronic Data Capture...

More Information

Publications109 found, 100 shown here

  1. Ni A, Cai J. A regularized variable selection procedure in additive hazards model with stratified case-cohort design. Lifetime Data Anal. 2018;24:443-463 pubmed publisher
    ..We establish the consistency and asymptotic normality of the penalized estimator and prove its oracle property...
  2. Farash M, Nawaz O, Mahmood K, Chaudhry S, Khan M. A Provably Secure RFID Authentication Protocol Based on Elliptic Curve for Healthcare Environments. J Med Syst. 2016;40:165 pubmed publisher
    ..To augment the security, we propose an efficient RFID authentication scheme using elliptic curves for healthcare environments. The proposed RFID scheme is secure under common random oracle model.
    ..These results show that the final estimator attains an oracle statistical property due to the usage of nonconvex penalty.
  4. Stylianou A, Gkretsi V, Patrickios C, Stylianopoulos T. Exploring the Nano-Surface of Collagenous and Other Fibrotic Tissues with AFM. Methods Mol Biol. 2017;1627:453-489 pubmed publisher
    ..calibration, data acquisition, analysis, and visualization, using two commercial AFM systems (PicoPlus and Cypher ES) and software that accompanied the AFM systems and/or are freeware available (WSxM, AtomicJ)...
  5. Fabri Ruiz S, Saucède T, Danis B, David B. Southern Ocean Echinoids database - An updated version of Antarctic, Sub-Antarctic and cold temperate echinoid database. Zookeys. 2017;:1-20 pubmed publisher
    ..1° per pixel. We also provide future projections for environmental descriptors established based on the Bio-Oracle database (Tyberghein et al. 2012).
  6. Dragisic Z, Ivanova V, Li H, Lambrix P. Experiences from the anatomy track in the ontology alignment evaluation initiative. J Biomed Semantics. 2017;8:56 pubmed publisher
    ..Further, interacting with an oracle is beneficial.
  7. Cheaito R, Tritar A, Scemama A, Ferrag W, Goy P, Haziza F, et al. [Very late drug-eluting stent thrombosis by stent fracture]. Ann Cardiol Angeiol (Paris). 2015;64:487-91 pubmed publisher
    ..We present the case of a patient admitted for myocardial infarction after a very late thrombosis of Cypher drug-eluting stent four years after its implantation and related to stent fracture.
  8. Dunn W, Burgun A, Krebs M, Rance B. Exploring and visualizing multidimensional data in translational research platforms. Brief Bioinform. 2017;18:1044-1056 pubmed publisher
    ..tranSMART, an unnamed data-cube-based model supporting heterogeneous data, Papilio, Caleydo Domino, Qlucore Omics, Oracle Health Sciences Translational Research Center and OmicsOffice® powered by TIBCO Spotfire...
  9. Li C, Wu T, Chen C, Lee C, Chen C. An Efficient User Authentication and User Anonymity Scheme with Provably Security for IoT-Based Medical Care System. Sensors (Basel). 2017;17: pubmed publisher
    ..Finally, the proposed scheme is provably secure in the random oracle model under ECDHP.
  10. Campbell J, Campbell W, Hickman H, Pedersen J, McClay J. Employing complex polyhierarchical ontologies and promoting interoperability of i2b2 data systems. AMIA Annu Symp Proc. 2015;2015:359-65 pubmed
    ..b>Oracle query plan resource estimates differed by one to three orders of magnitude for these queries...
  11. Omala A, Robert N, Li F. A Provably-Secure Transmission Scheme for Wireless Body Area Networks. J Med Syst. 2016;40:247 pubmed
    ..against adaptive chosen ciphertext attack and unforgeability against adaptive chosen message attack in random oracle model...
  12. He Q, Zhang H, Avery C, Lin D. Sparse meta-analysis with high-dimensional data. Biostatistics. 2016;17:205-20 pubmed publisher
    ..We show that the SMA enjoys the oracle property if the estimated covariance matrix of the parameter estimators from each study is available...
  13. Liu L, Wu F, Zhang W. Properties of sparse penalties on inferring gene regulatory networks from time-course gene expression data. IET Syst Biol. 2015;9:16-24 pubmed publisher
    ..are proposed to infer GRNs from time-course gene expression data based on an auto-regressive model and their Oracle properties are proved under mild conditions...
  14. Huling J, Yu M, Liang M, Smith M. Risk prediction for heterogeneous populations with application to hospital admission prediction. Biometrics. 2017;: pubmed publisher
    ..We prove an oracle property for our estimation method and show that even when the structural assumptions are misspecified, our method ..
  15. Wu L, Zhang Y, Li L, Shen J. Efficient and Anonymous Authentication Scheme for Wireless Body Area Networks. J Med Syst. 2016;40:134 pubmed publisher
    ..Then we present a novel anonymous authentication scheme for WBANs and prove that it's secure under a random oracle model...
  16. Zhu H, Tan Y, Zhu L, Wang X, Zhang Q, Li Y. An Identity-Based Anti-Quantum Privacy-Preserving Blind Authentication in Wireless Sensor Networks. Sensors (Basel). 2018;18: pubmed publisher
    ..Furthermore, we prove our scheme is secure in the random oracle, and satisfies confidentiality, integrity, and non-repudiation...
  17. Liu J, Zhang L, Sun R. 1-RAAP: An Efficient 1-Round Anonymous Authentication Protocol for Wireless Body Area Networks. Sensors (Basel). 2016;16: pubmed publisher
    ..1-RAAP is provably secure thanks to its design basis, which is resistant to the anonymous in the random oracle model...
  18. Chakraborty B, Ghosh P, Moodie E, Rush A. Estimating optimal shared-parameter dynamic regimens with application to a multistage depression clinical trial. Biometrics. 2016;72:865-76 pubmed publisher
    ..proposed method over simple competitors, in terms of the treatment allocation matching of the procedure with the "oracle" procedure, defined as the one that makes treatment recommendations based on the true parameter values as opposed ..
  19. Zhang Z, Xie X. Towards testing big data analytics software: the essential role of metamorphic testing. Biophys Rev. 2019;11:123-125 pubmed publisher
    ..Metamorphic testing, which was proposed to alleviate the oracle problem in the software engineering community, has become an effective approach for software verification and ..
  20. Das A. A secure user anonymity-preserving three-factor remote user authentication scheme for the telecare medicine information systems. J Med Syst. 2015;39:30 pubmed publisher
    ..Through the rigorous informal and formal security analysis using random oracle models and the widely-accepted AVISPA (Automated Validation of Internet Security Protocols and Applications) tool, ..
  21. Lee H, Lee D, Moon J, Jung J, Kang D, Kim H, et al. An improved anonymous authentication scheme for roaming in ubiquitous networks. PLoS ONE. 2018;13:e0193366 pubmed publisher
    ..We prove the security of the proposed scheme with the random oracle model and formally verify its security properties using a tool named ProVerif, and analyze it in terms of the ..
  22. Xu D, Chen J, Zhang S, Liu Q. Privacy-Preserving and Efficient Truly Three-Factor Authentication Scheme for Telecare Medical Information Systems. J Med Syst. 2018;42:219 pubmed publisher
    ..A formal proof analysis demonstrates that our proposed protocol is provably secure in the random oracle model. The performance evaluation shows that the proposed protocol is very efficient and suitable for TMISs.
  23. Hu J, Wang P, Qu A. Estimating and Identifying Unspecified Correlation Structure for Longitudinal Data. J Comput Graph Stat. 2015;24:455-476 pubmed
    ..We show that the proposed method possesses the oracle property and selects the true correlation structure consistently...
  24. Islam S, Khan M. Cryptanalysis and improvement of authentication and key agreement protocols for telecare medicine information systems. J Med Syst. 2014;38:135 pubmed publisher
    ..Our protocol is analyzed with the random oracle model and demonstrated to be formally secured against the hardness assumption of computational Diffie-Hellman ..
  25. Mir O, van der Weide T, Lee C. A Secure User Anonymity and Authentication Scheme Using AVISPA for Telecare Medical Information Systems. J Med Syst. 2015;39:89 pubmed publisher
    ..We prove the proposed scheme with random oracle and also use the BAN logic to prove the correctness of the proposed scheme...
  26. Lee T. Verifier-based three-party authentication schemes using extended chaotic maps for data exchange in telecare medicine information systems. Comput Methods Programs Biomed. 2014;117:464-72 pubmed publisher
    ..Additionally, the proposed scheme is proven secure in the random oracle model, and realizes the lower bounds of messages and rounds in communications...
  27. Kumar V, Jangirala S, Ahmad M. An Efficient Mutual Authentication Framework for Healthcare System in Cloud Computing. J Med Syst. 2018;42:142 pubmed publisher
    ..protects resilience of all possible security attributes, and we also explored formal security evaluation based on random oracle model. The performance of the proposed protocol is much better in comparison to the existing protocol.
  28. Danek B, Karatasakis A, Alame A, Nguyen Trong P, Karacsonyi J, Rangan B, et al. Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry. Catheter Cardiovasc Interv. 2017;89:E172-E180 pubmed publisher
    ..We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs)...
  29. Moon J, Lee D, Lee Y, Won D. Improving Biometric-Based Authentication Schemes with Smart Card Revocation/Reissue for Wireless Sensor Networks. Sensors (Basel). 2017;17: pubmed publisher
    ..analysis between previous schemes and the proposed scheme, and provide formal analysis based on the random oracle model...
  30. Omala A, Mbandu A, Mutiria K, Jin C, Li F. Provably Secure Heterogeneous Access Control Scheme for Wireless Body Area Network. J Med Syst. 2018;42:108 pubmed publisher
    ..against adaptive chosen ciphertext attack and unforgeability against adaptive chosen message attack in random oracle model is presented...
  31. Su X, Wijayasinghe C, Fan J, Zhang Y. Sparse estimation of Cox proportional hazards models via approximated information criteria. Biometrics. 2016;72:751-9 pubmed publisher
    ..The oracle property of the proposed method is established...
  32. Li S, Cui J, Zhong H, Liu L. Public Auditing with Privacy Protection in a Multi-User Model of Cloud-Assisted Body Sensor Networks. Sensors (Basel). 2017;17: pubmed publisher
    ..Experimental evaluations demonstrate the security effectiveness of our proposed scheme under the Random Oracle Model (ROM) by outperforming existing cloud-assisted WBSN models.
  33. Liu X, Ma W. CDAKA: A Provably-Secure Heterogeneous Cross-Domain Authenticated Key Agreement Protocol with Symptoms-Matching in TMIS. J Med Syst. 2018;42:135 pubmed publisher
    ..known possible attacks under the Elliptic Curve Computable Diffie-Hellman problem (ECDHP) assumption in the random oracle model...
  34. Zhou Y, Zhao X, Jiang Y, Shang F, Deng S, Wang X. An Enhanced Privacy-Preserving Authentication Scheme for Vehicle Sensor Networks. Sensors (Basel). 2017;17: pubmed publisher
    ..The security of our proposed scheme is proven under the random oracle model based on the assumption of the computational Diffie-Hellman problem.
  35. Wang S, Zhang X, Zhang Y. Efficiently Multi-User Searchable Encryption Scheme with Attribute Revocation and Grant for Cloud Storage. PLoS ONE. 2016;11:e0167157 pubmed publisher
    ..And our scheme is also of semantic security under indistinguishability against chosen keyword attack (IND-CKA) in the random oracle model.
  36. Sadi M, Kuo F, Ho J, Charleston M, Chen T. Verification of phylogenetic inference programs using metamorphic testing. J Bioinform Comput Biol. 2011;9:729-47 pubmed
    ..This difficulty is known as the oracle problem of software testing: there is no oracle that we can use to verify the correctness of the returned tree...
  37. Matteau A, Yeh R, Camenzind E, Steg P, Wijns W, Mills J, et al. Balancing Long-Term Risks of Ischemic and Bleeding Complications After Percutaneous Coronary Intervention With Drug-Eluting Stents. Am J Cardiol. 2015;116:686-93 pubmed publisher
    ..Patient-level data from Patient Related Outcomes With Endeavor vs Cypher Stenting Trial (PROTECT), a broadly inclusive trial enrolling 8,709 subjects treated with drug-eluting stents (..
  38. Estévez Loureiro R, Pérez de Prado A, Pérez Martínez C, Cuellas Ramón C, Regueiro Purriños M, Gonzalo Orden J, et al. Safety and Efficacy of New Sirolimus-eluting Stent Models in a Preclinical Study. Rev Esp Cardiol (Engl Ed). 2015;68:1118-24 pubmed publisher
    ..Sixty stents (conventional stent, new sirolimus-eluting stents: drug-eluting stents 1, 2 and 3; Cypher(®) and Xience(®)) were randomly placed in the coronary arteries of 20 Large White domestic pigs...
  39. Zhong W, Zhu L, Li R, Cui H. Regularized Quantile Regression and Robust Feature Screening for Single Index Models. Stat Sin. 2016;26:69-95 pubmed
    ..We establish an oracle property for the penalized quantile regression estimator when the covariate dimension increases at an exponential ..
  40. Artzi N, Tzafriri A, Faucher K, Moodie G, Albergo T, Conroy S, et al. Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating. Ann Biomed Eng. 2016;44:276-86 pubmed publisher
    ..sustained drug levels in porcine coronary arteries similarly to those achieved by slow-eluting durable coated Cypher Select Plus Stents and with significantly lower levels of granuloma formation and luminal stenosis...
  41. Xiang K, Li Y, FORD W, Land W, Schaffer J, Congdon R, et al. Automated analysis of food-borne pathogens using a novel microbial cell culture, sensing and classification system. Analyst. 2016;141:1472-82 pubmed publisher
    ..of Probabilistic Neural Network (PNN), Support Vector Machines (SVM) and General Regression Neural Network (GRNN) oracle-based system. Differential Pulse Voltammetry (DPV) is performed on standard samples or unknown samples...
  42. Hyogo M, Sawada T, Shiraishi J, Kohno Y. Nine-year follow-up of progressive peri-stent contrast staining after Cypher sirolimus-eluting stent implantation: a case report. Cardiovasc Interv Ther. 2017;32:279-286 pubmed publisher
    A 62-year-old male underwent three percutaneous coronary interventions involving four bare metal stents and six Cypher sirolimus-eluting stents within 1 month...
  43. Rot I, Baguma Nibasheka M, Costain W, Hong P, Tafra R, Mardesic Brakus S, et al. Role of skeletal muscle in ear development. Histol Histopathol. 2017;32:987-1000 pubmed publisher
    ..identify 6 candidate genes with a possible role in the development of the inner ear sensory organs: Actc1, Pgam2, Ldb3, Eno3, Hspb7 and Smpx...
  44. Marini M, Guglielmi V, Faulkner G, Piffer S, Tomelleri G, Vattemi G. Immunoblot as a potential diagnostic tool for myofibrillar myopathies. Electrophoresis. 2015;36:3097-100 pubmed publisher
    ..We investigated the pattern and level expression of desmin, αB-crystallin, myotilin, and ZASP (Z-band alternatively spliced PDZ motif-containing protein) in muscle of seven patients with MFMs by immunoblotting ..
  45. Møller P, Seppälä T, Bernstein I, Holinski Feder E, Sala P, Evans D, et al. Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database. Gut. 2017;66:464-472 pubmed publisher
    ..Standardised information on surveillance, cancers and outcomes were collated in an Oracle relational database and analysed by age, sex and mutated gene...
  46. Trippe Z, Brendani B, Meier C, Lewis D. Identification of Substandard Medicines via Disproportionality Analysis of Individual Case Safety Reports. Drug Saf. 2017;40:293-303 pubmed publisher
    ..three different stratification analyses using the Multi-item Gamma Poisson Shrinker (MGPS) algorithm through the Oracle Empirica data-mining software...
  47. Béhin A, Salort Campana E, Wahbi K, Richard P, Carlier R, Carlier P, et al. Myofibrillar myopathies: State of the art, present and future challenges. Rev Neurol (Paris). 2015;171:715-29 pubmed publisher
    ..The boundaries of this concept are still uncertain, and whereas six genes (DES, CRYAB, LDB3/ZASP, MYOT, FLNC and BAG3) are now classically considered as responsible for MFM, other entities such as FHL1 ..
  48. Levitas A, Konstantino Y, Muhammad E, Afawi Z, Marc Weinstein J, Amit G, et al. D117N in Cypher/ZASP may not be a causative mutation for dilated cardiomyopathy and ventricular arrhythmias. Eur J Hum Genet. 2016;24:666-71 pubmed publisher
    ..b>Cypher/ZASP is a cytoskeletal protein localized in the sarcomeric Z-line that has a pivotal role in maintaining adult ..
  49. Honeybul S, Ho K, Blacker D. ORACLE Stroke Study: Opinion Regarding Acceptable Outcome Following Decompressive Hemicraniectomy for Ischemic Stroke. Neurosurgery. 2016;79:231-6 pubmed publisher
    ..DESTINY, Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral ArterymRS, modified Rankin Scale. ..
  50. Deng Q, Fu F, Li R, Jing X, Lei T, Yang X, et al. [Application of chromosomal microarray analysis for fetuses with ventricular septal defects]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:699-704 pubmed publisher
    ..Candidate genes for VSD included WHSC1, LBX1, LDB3 and BBS10...
  51. Liu Y, Zhang J, Qiu X. Super-delta: a new differential gene expression analysis procedure with robust data normalization. BMC Bioinformatics. 2017;18:582 pubmed publisher
    ..In many cases, the performance of super-delta is close to that of an oracle test in which datasets without technical noise were used...
  52. Yano M, Natsuaki M, Morimoto T, Nakagawa Y, Kawai K, Miyazaki S, et al. Antiplatelet therapy discontinuation and stent thrombosis after sirolimus-eluting stent implantation: five-year outcome of the j-Cypher Registry. Int J Cardiol. 2015;199:296-301 pubmed publisher
    ..was evaluated in 12,812 consecutive patients undergoing sirolimus-eluting stents (SES) implantation in the j-Cypher registry. Data on status of antiplatelet therapy during follow-up were collected prospectively...
  53. Silva M, Alarcão A, Ferreira T, d Aguiar M, Ladeirinha A, Balseiro S, et al. Evaluation of HER2 by automated FISH and IHC in gastric carcinoma biopsies. Int J Biol Markers. 2016;31:e38-43 pubmed publisher
    ..The study used an Oracle HER2 IHC System and an LSI HER2/CEP17 Dual Probe on an automated Bond system (Leica Microsystems)...
  54. Sigler M, Klötzer J, Quentin T, Paul T, Möller O. Stent implantation into the tracheo-bronchial system in rabbits: histopathologic sequelae in bare metal vs. drug-eluting stents. Mol Cell Pediatr. 2015;2:10 pubmed publisher
    ..Bare metal and sirolimus-coated stents (Bx Sonic and Cypher Select, Johnson & Johnson, Cordis) were implanted into non-stenotic lower airways of New Zealand white rabbits ..
  55. Campbell W, Pedersen J, McClay J, Rao P, Bastola D, Campbell J. An alternative database approach for management of SNOMED CT and improved patient data queries. J Biomed Inform. 2015;57:350-7 pubmed publisher
    ..Queries, including concept negation and disjunction, were then run against the graph database and an enterprise Oracle relational database (RDBMS) of the same patient data sets...
  56. Kronenberg F, Schwaiger J. Risk scores-the modern Oracle of Delphi?. Kidney Int. 2017;91:536-538 pubmed publisher
    ..Nevertheless, the investigation of left ventricular mass and function has its own place for other reasons. ..
  57. Das A, Odelu V, Goswami A. A Secure and Robust User Authenticated Key Agreement Scheme for Hierarchical Multi-medical Server Environment in TMIS. J Med Syst. 2015;39:92 pubmed publisher
    ..using the widely-accepted Burrows-Abadi-Needham (BAN) logic, the formal security analysis under the random oracle model and the informal security analysis, we show that our scheme is secure against possible known attacks...
  58. Waseda K, Ako J, Kume T, Fitzgerald P, Honda Y. Characteristics of Late-Acquired Incomplete Stent Apposition: A Comparison With First-Generation and Second-Generation Drug-Eluting Stents. J Invasive Cardiol. 2016;28:323-9 pubmed
    ..was to investigate the morphometric parameters of late-acquired incomplete stent apposition (ISA) following use of Cypher sirolimus-eluting stent (SES; Cordis), Taxus paclitaxel-eluting stent (PES; Boston Scientific), and Resolute ..
  59. Lee J, Hahn J, Kang J, Park K, Chun W, Rha S, et al. Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions: Patient-Level Analysis of the Korean Bifurcation Pooled Cohorts. JACC Cardiovasc Interv. 2015;8:1318-31 pubmed publisher
    ..COBIS [Coronary Bifurcation Stenting] II, EXCELLENT [Registry to Evaluate Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting], and RESOLUTE-Korea [Registry to Evaluate the Efficacy of Zotarolimus-..
  60. Kang J, Park K, Han J, Yang H, Kang H, Koo B, et al. Usefulness of the Baseline Syntax Score to Predict 3-Year Outcome After Complete Revascularization by Percutaneous Coronary Intervention. Am J Cardiol. 2016;118:641-6 pubmed publisher
    ..From the Efficacy of Xience/Promus Versus Cypher in Reducing Late Loss After Stenting registry, the 3-year patient-oriented composite end point (POCE; all cause ..
  61. Wyles S, Li X, Hrstka S, Reyes S, Oommen S, Beraldi R, et al. Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells. Hum Mol Genet. 2016;25:254-65 pubmed publisher
    ..Furthermore, gene expression analysis for RBM20-dependent splice variants affected sarcomeric (TTN and LDB3) and calcium (Ca(2+)) handling (CAMK2D and CACNA1C) genes...
  62. Vincent A, Grady J, Rocha M, Alston C, Rygiel K, Barresi R, et al. Mitochondrial dysfunction in myofibrillar myopathy. Neuromuscul Disord. 2016;26:691-701 pubmed publisher
    ..They are caused by mutations in the DES, MYOT, CRYAB, FLNC, BAG3, DNAJB6 and ZASP genes as well as other as yet unidentified genes...
  63. Vihola A, Bachinski L, Sirito M, Olufemi S, Hajibashi S, Baggerly K, et al. Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2. Acta Neuropathol. 2010;119:465-79 pubmed publisher
    ..A subset of the abnormally regulated genes was further analyzed at the protein level. TNNT3 and LDB3 showed abnormal splicing with significant differences in proportions between DM2 and DM1...
  64. Lechuga S, Alarcón L, Solano J, Huerta M, Lopez Bayghen E, Gonzalez Mariscal L. Identification of ZASP, a novel protein associated to Zona occludens-2. Exp Cell Res. 2010;316:3124-39 pubmed publisher
    ..Through this assay we identified a 24-kDa novel protein herein named ZASP for ZO-2 associated speckle protein...
  65. Lin X, Ruiz J, Bajraktari I, Ohman R, Banerjee S, Gribble K, et al. Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) mutations in the actin-binding domain cause disruption of skeletal muscle actin filaments in myofibrillar myopathy. J Biol Chem. 2014;289:13615-26 pubmed publisher
    ..Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP)/Cypher interacts with ?-actinin, myotilin, and other Z-disc proteins via the PDZ domain...
  66. Danek B, Karatasakis A, Karacsonyi J, Alame A, Resendes E, Kalsaria P, et al. Long-term follow-up after near-infrared spectroscopy coronary imaging: Insights from the lipid cORe plaque association with CLinical events (ORACLE-NIRS) registry. Cardiovasc Revasc Med. 2017;18:177-181 pubmed publisher
    ..0% vs. 13.1% in the below-threshold group. During long-term follow-up of patients who underwent NIRS imaging, high LCBI in a non-PCI target vessel was associated with increased incidence of MACE. ..
  67. Vatta M, Mohapatra B, Jimenez S, Sanchez X, Faulkner G, Perles Z, et al. Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. J Am Coll Cardiol. 2003;42:2014-27 pubmed
    We evaluated the role of Cypher/ZASP in the pathogenesis of dilated cardiomyopathy (DCM) with or without isolated non-compaction of the left ventricular myocardium (INLVM)...
  68. Holmes W, Moncman C. Nebulette interacts with filamin C. Cell Motil Cytoskeleton. 2008;65:130-42 pubmed
    ..We have identified filamin-C, ZASP-1, and tropomyosin-1 as binding partners...
  69. Bos J, Theis J, Tajik A, Gersh B, Ommen S, Ackerman M. Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Am Heart J. 2008;155:1128-34 pubmed publisher
    ..Whereas mutations within the sarcomere appear to dominate the disease process, in their absence, sex has a significant modifying effect, specifically noted in cases of sigmoidal HCM. ..
  70. Xi Y, Ai T, de Lange E, Li Z, Wu G, Brunelli L, et al. Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol. 2012;5:1017-26 pubmed publisher
    ..D117N mutation in the LIM domain-binding protein 3-encoding Z-band alternatively spliced PDZ motif gene (ZASP) in a patient with left ventricular noncompaction and conduction disturbances...
  71. Faulkner G, Pallavicini A, Formentin E, Comelli A, Ievolella C, Trevisan S, et al. ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999;146:465-75 pubmed
    ..The transcript coding for this Z-band alternatively spliced PDZ motif (ZASP) protein maps on chromosome 10q22.3-10q23.2, near the locus for infantile-onset spinocerebellar ataxia.
  72. Arimura T, Hayashi T, Terada H, Lee S, Zhou Q, Takahashi M, et al. A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. J Biol Chem. 2004;279:6746-52 pubmed
    ..b>Cypher/ZASP appears to be an ideal candidate for the cardiomyopathy causative gene, because Cypher/ZASP encodes a Z-disc ..
  73. Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, et al. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 2009;83:80-8 pubmed publisher
    Z-band alternatively spliced PDZ-motif protein (ZASP)/Cypher is a Z-disc component of which several dilated cardiomyopathy (DCM)-associated mutations have been reported...
  74. Rampersaud E, Kinnamon D, Hamilton K, Khuri S, Hershberger R, Martin E. Common susceptibility variants examined for association with dilated cardiomyopathy. Ann Hum Genet. 2010;74:110-6 pubmed publisher
    ..analyses on all DNA polymorphic variation identified in a resequencing study of six candidate DCM genes (CSRP3, LDB3, MYH7, SCN5A, TCAP, and TNNT2) conducted in 289 unrelated white probands with DCM of unknown cause and 188 ..
  75. Yamashita Y, Matsuura T, Kurosaki T, Amakusa Y, Kinoshita M, Ibi T, et al. LDB3 splicing abnormalities are specific to skeletal muscles of patients with myotonic dystrophy type 1 and alter its PKC binding affinity. Neurobiol Dis. 2014;69:200-5 pubmed publisher
    ..Here, we demonstrate the occurrence of aberrant splicing of LIM domain binding 3 (LDB3) exon 11 in DM1 skeletal muscle...
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    ..High-throughput sequencing examinations showed a novel mutation in the LDB3 gene (c.C793>T; p.Arg265Cys)...
  77. Freedman M, Leist T, Comi G, Cree B, Coyle P, Hartung H, et al. The efficacy of cladribine tablets in CIS patients retrospectively assigned the diagnosis of MS using modern criteria: Results from the ORACLE-MS study. Mult Scler J Exp Transl Clin. 2017;3:2055217317732802 pubmed publisher
    Multiple sclerosis (MS) diagnostic criteria have changed since the ORACLE-MS study was conducted; 223 of 616 patients (36.2%) would have met the diagnosis of MS vs clinically isolated syndrome (CIS) using the newer criteria.
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    ..non-compaction transmitted as an autosomal dominant condition has also been associated with LIM domain-binding 3 (LDB3) gene defects. We describe a family in which the 12-year-old proband had left ventricular non-compaction and DCM...
  79. Cai H, Yabe I, Sato K, Kano T, Nakamura M, Hozen H, et al. Clinical, pathological, and genetic mutation analysis of sporadic inclusion body myositis in Japanese people. J Neurol. 2012;259:1913-22 pubmed publisher
    ..a clinicopathological analysis of 21 sIBM patients and screened for mutations in the Desmin, GNE, MYHC2A, VCP, and ZASP genes. All coding exons of the five genes were sequenced directly...
  80. Zhou Q, Ruiz Lozano P, Martone M, Chen J. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem. 1999;274:19807-13 pubmed
    We have cloned and characterized a novel striated muscle-restricted protein (Cypher) that has two mRNA splice variants, designated Cypher1 and Cypher2. Both proteins contain an amino-terminal PDZ domain...
  81. Leung M, Hitchen P, Ward D, Messer A, Marston S. Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked ?-N-acetylglucosamine-substituted protein in human heart myofibrils. J Biol Chem. 2013;288:4891-8 pubmed publisher
    ..MALDI-MS/MS identified the 90-kDa band as the protein ZASP (Z-band alternatively spliced PDZ motif protein), a minor component of the Z-disc (about 1 per 400 ?-actinin) ..
  82. Auld A, Folker E. Nucleus-dependent sarcomere assembly is mediated by the LINC complex. Mol Biol Cell. 2016;27:2351-9 pubmed publisher
    ..We show that nuclear positioning precedes sarcomere formation. Furthermore, ZASP-GFP, a Z-line protein, colocalizes with F-actin in puncta at the cytoplasmic face of nuclei before sarcomere ..
  83. Xia Y, Li L. Hypothesis testing of matrix graph model with application to brain connectivity analysis. Biometrics. 2017;73:780-791 pubmed publisher
    ..Based on the separable spatial-temporal dependence structure, we develop oracle and data-driven procedures to test both the global hypothesis that all spatial locations are conditionally ..
  84. van der Laan M. A Generally Efficient Targeted Minimum Loss Based Estimator based on the Highly Adaptive Lasso. Int J Biostat. 2017;13: pubmed publisher
    ..rate of convergence of the HAL, but, by previous results, it will actually be asymptotically equivalent with the oracle (i.e., in some sense best) estimator in the library...
  85. Passier R, Richardson J, Olson E. Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle. Mech Dev. 2000;92:277-84 pubmed
    ..We identified two alternative splicing variants of a novel PDZ-LIM domain protein, which we named Oracle. Both variants contain a PDZ domain at the amino-terminus and three LIM domains at the carboxy-terminus...
  86. Klaavuniemi T, Ylanne J. Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin--analysis of patient mutations. Exp Cell Res. 2006;312:1299-311 pubmed
    Z-band alternatively spliced PDZ-containing protein (ZASP/Cypher) has an important role in maintaining Z-disc stability in striated and cardiac muscle...
  87. Hunt W, Kaufmann M, Moore J, Slobodova A. Industrial hardware and software verification with ACL2. Philos Trans A Math Phys Eng Sci. 2017;375: pubmed publisher
    ..that have used ACL2 regularly include AMD, Centaur Technology, IBM, Intel, Kestrel Institute, Motorola/Freescale, Oracle and Rockwell Collins. This paper introduces ACL2 and focuses on how and why ACL2 is used in industry...
  88. Yoon J, Gurusamy D, Palli S. Accumulation of dsRNA in endosomes contributes to inefficient RNA interference in the fall armyworm, Spodoptera frugiperda. Insect Biochem Mol Biol. 2017;90:53-60 pubmed publisher
    ..b>CypHer-5E-labeled dsRNA also accumulated in the midgut and fat body dissected from Spodoptera frugiperda larvae with ..
  89. Wei L, Gregorich Z, Lin Z, Cai W, Jin Y, McKiernan S, et al. Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics. Mol Cell Proteomics. 2018;17:134-145 pubmed publisher
    ..Surprisingly, age-related alterations in the phosphorylation of Cypher isoforms, proteins that localize to the Z-discs in striated muscles, were also noted in the fast-twitch skeletal ..
  90. Liu H, Yao T, Li R, Ye Y. Folded concave penalized sparse linear regression: sparsity, statistical performance, and algorithmic theory for local solutions. Math Program. 2017;166:207-240 pubmed publisher
    ..In addition, if the minimal signal strength is sufficient, the S3ONC solution likely recovers the oracle solution...
  91. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, et al. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013;288:29403-13 pubmed publisher
    ..b>Cypher/ZASP, a member of PDZ-LIM domain protein family, is a cytoskeletal protein that forms multiprotein complexes at ..
  92. Watts N, Zhuang X, Kaufman J, Palmer I, Dearborn A, Coscia S, et al. Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin. Biochemistry. 2017;56:2061-2070 pubmed publisher
    Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) is a principal component of the sarcomere. The three prevalent isoforms of ZASP in skeletal muscle are generated by alternative splicing of exons 9 and 10...