LCN2

Summary

Gene Symbol: LCN2
Description: lipocalin 2
Alias: 24p3, MSFI, NGAL, p25, neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, migration-stimulating factor inhibitor, oncogene 24p3, siderocalin LCN2
Species: human
Products:     LCN2

Top Publications

  1. Zerega B, Cermelli S, Michelis B, Cancedda R, Cancedda F. Expression of NRL/NGAL (neu-related lipocalin/neutrophil gelatinase-associated lipocalin) during mammalian embryonic development and in inflammation. Eur J Cell Biol. 2000;79:165-72 pubmed
    ..is SIP24, an acute phase protein induced in the animal by turpentine injection; the human homologous protein is NGAL expressed in granulocytes and epithelial cells in pathological conditions, such as inflammation and malignancy...
  2. Wallenius V, Elias E, Bergstrom G, Zetterberg H, Behre C. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old. Exp Clin Endocrinol Diabetes. 2011;119:75-80 pubmed publisher
    ..Rather the expression levels of lipocalin-2 and L-PGDS, but not RBP-4, seemed to reflect inflammatory activity and were inversely correlated with alcohol intake and serum HDL levels. ..
  3. Sun Y, Yokoi K, Li H, Gao J, Hu L, Liu B, et al. NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models. Clin Cancer Res. 2011;17:4331-40 pubmed publisher
    There is growing evidence implicating that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in the development and progression of cancers...
  4. Devarajan P. Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant. 2008;23:3737-43 pubmed publisher
  5. Nielsen S, Hansen H, Jensen B, Parving H, Rossing P. Urinary neutrophil gelatinase-associated lipocalin and progression of diabetic nephropathy in type 1 diabetic patients in a four-year follow-up study. Nephron Clin Pract. 2011;118:c130-5 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL), a marker of renal tubular damage, predicts progression in non-diabetic chronic kidney...
  6. Fung K, Priebe I, Purins L, Tabor B, Brierley G, Lockett T, et al. Performance of serum lipocalin 2 as a diagnostic marker for colorectal cancer. Cancer Biomark. 2013;13:75-9 pubmed publisher
    ..641 (95% confidence interval 0.576-0.706). Furthermore, the sensitivity of lipocalin 2 was found to be 24% at 90% specificity. Our study indicates that lipocalin 2 is not a suitable serum biomarker for the diagnosis of CRC. ..
  7. Barresi V, Leni A, Tuccari G, Barresi G. Neutrophil gelatinase-associated lipocalin (NGAL) immunohistochemical expression in follicular cell-derived thyroid tumors: a novel diagnostic tool?. Histol Histopathol. 2012;27:329-36 pubmed publisher
    ..In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort of tumors including 8 ..
  8. Singer E, Elger A, Elitok S, Kettritz R, Nickolas T, Barasch J, et al. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int. 2011;80:405-14 pubmed publisher
    ..In this study, we tested whether urinary neutrophil gelatinase-associated lipocalin (NGAL) distinguishes between intrinsic and prerenal AKI, and tested its performance in predicting a composite outcome ..
  9. Bolignano D, Coppolino G, Donato V, Lacquaniti A, Bono C, Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL): a new piece of the anemia puzzle?. Med Sci Monit. 2010;16:RA131-5 pubmed
    Neutrophil Gelatinase-Associated Lipocalin (NGAL), a small 25-kD peptide, originally discovered as an antibacterial factor of natural immunity and an acute-phase protein, represents a key factor in the regulation of erythrocyte growth due ..

More Information

Publications95

  1. Haase M, Devarajan P, Haase Fielitz A, Bellomo R, Cruz D, Wagener G, et al. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011;57:1752-61 pubmed publisher
    ..that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis...
  2. Bahmani P, Halabian R, Rouhbakhsh M, Roushandeh A, Masroori N, Ebrahimi M, et al. Neutrophil gelatinase-associated lipocalin induces the expression of heme oxygenase-1 and superoxide dismutase 1, 2. Cell Stress Chaperones. 2010;15:395-403 pubmed publisher
    Lipocalin-2 (Lcn2, NGAL) is a member of the lipocalin super family with diverse function such as the induction of apoptosis, the suppression of bacterial growth, and modulation of inflammatory response...
  3. Bolignano D, Donato V, Lacquaniti A, Fazio M, Bono C, Coppolino G, et al. Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 2010;288:10-6 pubmed publisher
    The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved ..
  4. Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T. Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma. Exp Mol Pathol. 2011;91:563-8 pubmed publisher
    We previously reported the overexpression of lipocalin2 (LCN2), a 25kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis...
  5. Mannelqvist M, Stefansson I, Wik E, Kusonmano K, Raeder M, Øyan A, et al. Lipocalin 2 expression is associated with aggressive features of endometrial cancer. BMC Cancer. 2012;12:169 pubmed publisher
    Increased expression of lipocalin 2 (LCN2) has been observed in several cancers...
  6. Aydogdu M, Gursel G, Sancak B, Yeni S, Sarı G, Tasyurek S, et al. The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C in early diagnosis of septic acute kidney injury in critically ill patients. Dis Markers. 2013;34:237-46 pubmed publisher
    To assess and compare the roles of plasma and urine concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis of septic acute kidney injury (AKI) in adult critically ill patients...
  7. Lebkowska U, Malyszko J, Lebkowska A, Koc Zorawska E, Lebkowski W, Malyszko J, et al. Neutrophil gelatinase-associated lipocalin and cystatin C could predict renal outcome in patients undergoing kidney allograft transplantation: a prospective study. Transplant Proc. 2009;41:154-7 pubmed publisher
    Urinary neutrophil gelatinase-associated lipocalin (NGAL) may represent an early, predictive biomarker of delayed graft function due to ischemia-reperfusion injury...
  8. Huynh T, Bateman D, Parravicini E, Lorenz J, Nemerofsky S, Sise M, et al. Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr Res. 2009;66:528-32 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is an early and sensitive indicator of renal impairment in experimental animals, children, and adults...
  9. Bolignano D, Coppolino G, Lacquaniti A, Nicocia G, Buemi M. Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function. Kidney Blood Press Res. 2008;31:274-9 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is a stress protein released by tubular cells which urinary excretion (uNGAL) increases in response to various ..
  10. Zhang Y, Fan Y, Mei Z. NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification. Cancer Epidemiol. 2012;36:e294-9 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) and its cell surface receptor, NGALR, have been implicated in tumorigenesis and tumor progression of various human malignant neoplasms...
  11. Portal A, McPhail M, Bruce M, Coltart I, Slack A, Sherwood R, et al. Neutrophil gelatinase--associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation. Liver Transpl. 2010;16:1257-66 pubmed publisher
    ..Novel methods of assessing AKI including cystatin C (CyC) and neutrophil gelatinase-associated lipocalin (NGAL) have been identified as potential markers of AKI...
  12. Malyszko J, Malyszko J, Koc Zorawska E, Kozminski P, Mysliwiec M. Neutrophil gelatinase-associated lipocalin in dialyzed patients is related to residual renal function, type of renal replacement therapy and inflammation. Kidney Blood Press Res. 2009;32:464-9 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) has recently been proved useful in the quantitation of chronic kidney disease...
  13. Parikh C, Devarajan P, Zappitelli M, Sint K, Thiessen Philbrook H, Li S, et al. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol. 2011;22:1737-47 pubmed publisher
    ..to evaluate whether early postoperative measures of urine IL-18, urine neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would develop AKI and other adverse outcomes...
  14. Mussap M, Noto A, Fravega M, Fanos V. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and netrin-1: are they effectively improving the clinical management of sepsis-induced acute kidney injury (AKI)?. J Matern Fetal Neonatal Med. 2011;24 Suppl 2:15-7 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) and Netrin-1 have been proposed over the past years as emergent biomarkers for the early and accurate diagnosis and monitoring of acute kidney injury (AKI)...
  15. Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Early Hum Dev. 2013;89:425-9 pubmed publisher
    ..novel predictive marker of BPD development, we studied serum levels of neutrophil gelatinase-associated lipocalin (NGAL), an innate immune mediator, in preterm infants...
  16. Poniatowski B, Malyszko J, Bachorzewska Gajewska H, Malyszko J, Dobrzycki S. Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in patients with chronic heart failure and coronary artery disease. Kidney Blood Press Res. 2009;32:77-80 pubmed publisher
    ..The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of kidney function in adult patients with chronic heart failure and ..
  17. Miethke M, Skerra A. Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition. Antimicrob Agents Chemother. 2010;54:1580-9 pubmed publisher
    ..NE resemble those of bacterial siderophores that are scavenged by human neutrophil gelatinase-associated lipocalin (NGAL) as part of the innate immune defense...
  18. Malyszko J, Malyszko J, Mysliwiec M. Serum neutrophil gelatinase-associated lipocalin correlates with kidney function in renal allograft recipients. Clin Transplant. 2009;23:681-6 pubmed publisher
    The value of neutrophil gelatinase-associated lipocalin (NGAL) as a novel marker for early detection of acute renal failure has been highlighted recently...
  19. Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, Asami F, et al. Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis. Circ J. 2010;74:523-30 pubmed
    Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation...
  20. Nickolas T, Forster C, Sise M, Barasch N, Solá Del Valle D, Viltard M, et al. NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int. 2012;82:718-22 pubmed publisher
    ..We used immunoblots and ARCHITECT-NGAL assays to define the immunoreactivity of urinary neutrophil gelatinase-associated lipocalin (NGAL) in CKD, and we ..
  21. Viau A, El Karoui K, Laouari D, Burtin M, Nguyen C, Mori K, et al. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest. 2010;120:4065-76 pubmed publisher
    ..Our results showed that lipocalin 2 (Lcn2, also known as neutrophil gelatinase-associated lipocalin [NGAL]), the most highly upregulated gene in the FVB/N strain, was not simply a marker of renal lesions, but an active ..
  22. Latouche C, El Moghrabi S, Messaoudi S, Nguyen Dinh Cat A, Hernández Díaz I, Alvarez de la Rosa D, et al. Neutrophil gelatinase-associated lipocalin is a novel mineralocorticoid target in the cardiovascular system. Hypertension. 2012;59:966-72 pubmed publisher
    ..Using a pan-genomic transcriptomic analysis, we identified neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2) as a strongly induced gene in the heart of mice with conditional and targeted MR overexpression in ..
  23. Fougere M, Gaudineau B, Barbier J, Guaddachi F, Feugeas J, Auboeuf D, et al. NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene. Oncogene. 2010;29:2292-301 pubmed publisher
    ..NFAT3 signaling reduces migration through inhibition of Lipocalin 2 (LCN2) gene expression...
  24. Candido S, Maestro R, Polesel J, Catania A, Maira F, Signorelli S, et al. Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer. Oncotarget. 2014;5:1576-94 pubmed
    ..Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as a key player in different cancer types...
  25. Tung M, Hsieh S, Yang S, Cheng C, Tsai R, Wang S, et al. Knockdown of lipocalin-2 suppresses the growth and invasion of prostate cancer cells. Prostate. 2013;73:1281-90 pubmed publisher
    Lipocalin-2 (LCN2) is a member of the lipocalin superfamily, and it has an important role in the regulation of cellular oncogenesis and apoptosis. However, the role for LCN2 in prostate cancer remains unclear...
  26. Haase Fielitz A, Haase M, Devarajan P. Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem. 2014;51:335-51 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising non-invasive biomarker of kidney injury...
  27. Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, et al. Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int. 2009;75:285-94 pubmed publisher
    Urinary neutrophil gelatinase-associated lipocalin (Ngal or lipocalin 2) is a very early and sensitive biomarker of kidney injury...
  28. Eirin A, Gloviczki M, Tang H, Rule A, Woollard J, Lerman A, et al. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Nephrol Dial Transplant. 2012;27:4153-61 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein induced in inflammatory conditions and ischemia, is a novel biomarker for acute kidney ..
  29. Tsai H, Su P, Lee T, Tee Y, Lin L, Yang S, et al. Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease. Clin Chim Acta. 2011;412:1252-6 pubmed publisher
    To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID)...
  30. Leung J, Lam M, Tang S, Chan L, Tam K, Yip T, et al. Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis. J Clin Immunol. 2009;29:365-78 pubmed publisher
    We measured the neutrophil gelatinase-associated lipocalin (NGAL) concentration in peritoneal dialysate effluent (PDE) collected following an acute episode of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis...
  31. Huang Y, Yang Z, Ye Z, Li Q, Wen J, Tao X, et al. Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people. Cardiovasc Diabetol. 2012;11:11 pubmed publisher
    ..31 (95% CI 1.21-1.69, p < 0.001). Our findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes. ..
  32. Jeong T, Kim S, Lee W, Song G, Kim Y, Chun S, et al. Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in liver transplantation. Clin Transplant. 2012;26:775-81 pubmed publisher
    ..We evaluated the utility of urine and plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations as biomarkers of AKI during and after liver transplantation...
  33. Liao C, Huang Y, Au H, Wang L, Chu S. The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia. Mol Biol Rep. 2012;39:1029-36 pubmed publisher
    ..The Lcn-2 gene encodes neutrophil gelatinase-associated lipocalin (NGAL), which promotes cell proliferation and serves as a cancer marker in some cancers...
  34. Yang W, Lin P, Yang M, Liu Y, Chang C, Chou W, et al. Higher lipocalin 2 expression may represent an independent favorable prognostic factor in cytogenetically normal acute myeloid leukemia. Leuk Lymphoma. 2013;54:1614-25 pubmed publisher
    ..Lipocalin 2 (LCN2) is related to cancer development and is believed to be associated with the outcome of cytogenetically normal (CN)-..
  35. Romaní J, Caixàs A, Ceperuelo Mallafré V, Carrascosa J, Ribera M, Rigla M, et al. Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI. Arch Dermatol Res. 2013;305:105-12 pubmed publisher
    ..This component was absent in the patients. Our results point to lipocalin-2 and RBP-4 as relevant mediators of the trend towards MS in psoriatic patients. ..
  36. Sabo E, Meitner P, Tavares R, Corless C, Lauwers G, Moss S, et al. Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue. Clin Cancer Res. 2008;14:6440-8 pubmed publisher
    ..The genes identified include several previously implicated in the pathogenesis of BE-associated dysplasia and new candidates for further investigation. ..
  37. Fan H, Zhao Y, Zhu J, Song F. Urine neutrophil gelatinase-associated lipocalin in septic patients with and without acute kidney injury. Ren Fail. 2014;36:1399-403 pubmed publisher
    ..12; 95% CI: 6.21-90.37; p?<?0.0001). uNGAL is independently associated with subsequent AKI among patients with sepsis. ..
  38. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54:1012-24 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker for the early diagnosis of acute kidney injury (AKI); however, a wide range in its predictive value has been reported...
  39. Catalan V, Gomez Ambrosi J, Rodríguez A, Ramirez B, Silva C, Rotellar F, et al. Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J Nutr Biochem. 2011;22:634-41 pubmed publisher
    ..This observation together with the up-regulation of angiogenic factors suggests that adipokines secreted by VAT may be involved in the development of colon cancer. ..
  40. Peralta C, Katz R, Bonventre J, Sabbisetti V, Siscovick D, Sarnak M, et al. Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis. 2012;60:904-11 pubmed publisher
    ..elevations in levels of urinary biomarkers of tubular injury (urine neutrophil gelatinase-associated lipocalin [NGAL] and kidney injury molecule 1 [KIM-1]) are associated with future risk of kidney disease has not been investigated...
  41. Martí J, Fuster J, Solà A, Hotter G, Molina R, Pelegrina A, et al. Prognostic value of serum neutrophil gelatinase-associated lipocalin in metastatic and nonmetastatic colorectal cancer. World J Surg. 2013;37:1103-9 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) expression is increased in epithelial cancer patients, but studies showing its relation to prognosis are scarce...
  42. Bolignano D, Lacquaniti A, Coppolino G, Donato V, Fazio M, Nicocia G, et al. Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients. Kidney Blood Press Res. 2009;32:91-8 pubmed publisher
    ..With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort of 56 patients with type 2 diabetes ..
  43. Bolignano D, Lacquaniti A, Coppolino G, Donato V, Campo S, Fazio M, et al. Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. Clin J Am Soc Nephrol. 2009;4:337-44 pubmed publisher
    ..The authors aimed to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), a novel specific biomarker of acute kidney injury, could predict the progression of CKD...
  44. McIlroy D, Wagener G, Lee H. Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. Clin J Am Soc Nephrol. 2010;5:211-9 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) is rapidly released by renal tubules after injury, potentially allowing early identification of acute kidney injury (AKI) after cardiac surgery...
  45. Wenners A, Mehta K, Loibl S, Park H, Mueller B, Arnold N, et al. Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer. PLoS ONE. 2012;7:e45826 pubmed publisher
    In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis...
  46. Yang J, Bielenberg D, Rodig S, Doiron R, Clifton M, Kung A, et al. Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci U S A. 2009;106:3913-8 pubmed publisher
    Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, and we identify the mechanisms underlying this function...
  47. Chakraborty S, Kaur S, Muddana V, Sharma N, Wittel U, Papachristou G, et al. Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of severity and outcome in acute pancreatitis. Am J Gastroenterol. 2010;105:2050-9 pubmed publisher
    ..In this study, we investigated the potential of serum neutrophil gelatinase-associated lipocalin (NGAL) as an early marker to distinguish severe (SAP) from MAP and examine its ability to predict the prognosis of ..
  48. Zhu W, Liu M, Wang G, Che J, Xu Y, Peng B, et al. Urinary neutrophil gelatinase-associated lipocalin, a biomarker for systemic inflammatory response syndrome in patients with nephrolithiasis. J Surg Res. 2014;187:237-43 pubmed publisher
    The objective of this study was to determine the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL), C-reactive protein (CRP), and procalcitonin (PCT) in the prognosis of patients presenting with the systemic ..
  49. Iannetti A, Pacifico F, Acquaviva R, Lavorgna A, Crescenzi E, Vascotto C, et al. The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci U S A. 2008;105:14058-63 pubmed publisher
    ..Proteomic analysis revealed that the neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in inflammatory and immune responses, is secreted by FRO cells whereas its expression is ..
  50. Chappell W, Abrams S, Montalto G, Cervello M, Martelli A, Candido S, et al. Effects of ectopic expression of NGAL on doxorubicin sensitivity. Oncotarget. 2012;3:1236-45 pubmed
    Neutrophil gelatinase-associated lipocalin (NGAL, a.k...
  51. Aghel A, Shrestha K, Mullens W, Borowski A, Tang W. Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail. 2010;16:49-54 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is produced by the nephron in response to tubular epithelial damage and serves as an early marker for acute renal ..
  52. Lee E, Kim M, Park Y, Kim H. Serum neutrophil gelatinase-associated lipocalin and interleukin-18 as predictive biomarkers for delayed graft function after kidney transplantation. J Clin Lab Anal. 2012;26:295-301 pubmed publisher
    ..We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation...
  53. Li S, Hawthorne V, Neal C, Sanghera S, Xu J, Yang J, et al. Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer Res. 2009;69:9163-8 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted glycoprotein expressed in a variety of cancers, including breast carcinomas...
  54. Cakal E, Ozkaya M, Engin Ustun Y, Ustun Y. Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome. J Endocrinol Invest. 2011;34:97-100 pubmed publisher
    ..In our study, lipocalin-2 levels were found to be significantly higher in women with PCOS compared to body mass index-matched controls. Serum lipocalin-2 may prove to be a useful marker for insulin resistance in patients with PCOS. ..
  55. El Hadidi H, Samir N, Shaker O, Otb S. Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome. Arch Dermatol Res. 2014;306:239-45 pubmed publisher
    ..Lipocalin-2 has no role in determining severity of the disease. Neither tissue nor serum lipocalin-2 conveys cardiovascular risk in psoriasis patients. ..
  56. Syrjanen S, Naud P, Sarian L, Derchain S, Roteli Martins C, Tatti S, et al. Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia. Am J Clin Pathol. 2010;134:50-9 pubmed publisher
    Our objective was to assess whether neutrophil gelatinase-associated lipocalin (NGAL)/lipocalin 2 (LCN2) expression in cervical human papillomavirus (HPV) lesions has implications on the outcome of HPV infections or disease progression...
  57. Hu L, Hittelman W, Lu T, Ji P, Arlinghaus R, Shmulevich I, et al. NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells. Lab Invest. 2009;89:531-48 pubmed publisher
    Expression of neutrophil gelatinase-associated lipocalin (NGAL)/lipocalin2, a recently recognized iron regulatory protein that binds to matrix metalloproteinase-9 (MMP9), is increased in a spectrum of cancers, including those of the ..
  58. Barresi V, Di Gregorio C, Reggiani Bonetti L, Ieni A, Ponz de Leon M, Barresi G. Neutrophil gelatinase-associated lipocalin: a new prognostic marker in stage I colorectal carcinoma?. Hum Pathol. 2011;42:1720-6 pubmed publisher
  59. Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, et al. Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance. Hum Pathol. 2011;42:1265-74 pubmed publisher
    ..We focused on lipocalin2 (LCN2), which showed the largest magnitude of up-regulation...
  60. McLean M, Thomson A, Murray G, Fyfe N, Hold G, El Omar E. Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?. Br J Cancer. 2013;108:2537-41 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) has a diverse functional repertoire, involved in the innate immune response as well as cell growth and differentiation...
  61. Lin H, Liao C, Lee Y, Hu K, Meng H, Chu S. Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration. Int J Biol Sci. 2011;7:74-86 pubmed
    ..We hypothesize that Lcn-2 increased cytokine secretion by RL95-2 cells, which in turn activated a cellular defense system. This study suggests that Lcn-2 may play a role in the human female reproductive system or in endometrial cancer. ..
  62. Niemann C, Walia A, Waldman J, Davio M, Roberts J, Hirose R, et al. Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin. Liver Transpl. 2009;15:1852-60 pubmed publisher
    ..enrolled liver transplant patients at our institutions to evaluate neutrophil gelatinase-associated lipocalin (NGAL), a marker of early renal injury, as a surrogate for AKI in patients undergoing liver transplantation...
  63. Yilmaz A, Sevketoglu E, Gedikbasi A, Karyagar S, Kiyak A, Mulazimoglu M, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24:2387-92 pubmed publisher
    b>Neutrophil gelatinase associated lipocalin (NGAL) is a protein identified in human neutrophil granules...
  64. Pickering J, Endre Z. The clinical utility of plasma neutrophil gelatinase-associated lipocalin in acute kidney injury. Blood Purif. 2013;35:295-302 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) is derived from the distal tubule and is both reabsorbed and filtered and also shed into the urine after tubular injury...
  65. Perry T, Muehlschlegel J, Liu K, Fox A, Collard C, Shernan S, et al. Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg. 2010;110:1541-7 pubmed publisher
    ..We hypothesized that increased plasma neutrophil gelatinase-associated lipocalin (NGAL) measured immediately after separating from cardiopulmonary bypass (CPB) would predict AKI after CABG surgery...
  66. Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, et al. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009;69:8579-84 pubmed publisher
    Lipocalin 2 (LCN2; also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear...
  67. Barresi V, Vitarelli E, Reggiani Bonetti L, Tuccari G, Barresi G. Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) immunoexpression in follicular-patterned lesions of the thyroid gland. Virchows Arch. 2012;460:319-25 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) is a protein which participates in iron trafficking and which is involved in cancerogenesis and cancer progression...
  68. Parravicini E, Nemerofsky S, Michelson K, Huynh T, Sise M, Bateman D, et al. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. Pediatr Res. 2010;67:636-40 pubmed publisher
    ..05 to <0.005). uNGAL shows promise as an early marker for culture-positive sepsis in VLBW infants. ..
  69. Barresi V, Ieni A, Bolignano D, Magno C, Buemi M, Barresi G. Neutrophil gelatinase-associated lipocalin immunoexpression in renal tumors: correlation with histotype and histological grade. Oncol Rep. 2010;24:305-10 pubmed
    Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias...
  70. Wagener G, Gubitosa G, Wang S, Borregaard N, Kim M, Lee H. A comparison of urinary neutrophil gelatinase-associated lipocalin in patients undergoing on- versus off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2009;23:195-9 pubmed publisher
    The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery. A matched cohort study. A tertiary university hospital...
  71. Wagener G, Minhaz M, Mattis F, Kim M, Emond J, Lee H. Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation. Nephrol Dial Transplant. 2011;26:1717-23 pubmed publisher
    Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a novel, sensitive and specific biomarker that is rapidly released after kidney injury. It predicts acute kidney injury (AKI) in multiple clinical scenarios...
  72. Alvelos M, Pimentel R, Pinho E, Gomes A, Lourenço P, Teles M, et al. Neutrophil gelatinase-associated lipocalin in the diagnosis of type 1 cardio-renal syndrome in the general ward. Clin J Am Soc Nephrol. 2011;6:476-81 pubmed publisher
    ..This study aimed to assess the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in the early detection of type 1 cardio-renal syndrome in patients with acute HF...
  73. Malyszko J, Malyszko J, Bachorzewska Gajewska H, Poniatowski B, Dobrzycki S, Mysliwiec M. Neutrophil gelatinase-associated lipocalin is a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients. Transplant Proc. 2009;41:158-61 pubmed publisher
    Few biomarkers exist to monitor chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL), a member of lipocalin family, has recently been proven useful to quantitate CKD...
  74. Woo H, Min J, Bai C, Song S, Kang H, Lee H, et al. Expression of neutrophil gelatinase-associated lipocalin in nasal polyps. Arch Otolaryngol Head Neck Surg. 2008;134:1182-6 pubmed publisher
    To investigate the expression and localization of neutrophil gelatinase-associated lipocalin (NGAL), an antimicrobial peptide, in the normal nasal mucosa and human nasal polyps...
  75. Jung M, Weigert A, Tausendschön M, Mora J, Oren B, Sola A, et al. Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth. Mol Cell Biol. 2012;32:3938-48 pubmed publisher
    ..Here we explored molecular mechanisms allowing IL-10 to upregulate the protumorigenic protein NGAL in primary human macrophages...
  76. Bojan M, Vicca S, Lopez Lopez V, Mogenet A, Pouard P, Falissard B, et al. Predictive performance of urine neutrophil gelatinase-associated lipocalin for dialysis requirement and death following cardiac surgery in neonates and infants. Clin J Am Soc Nephrol. 2014;9:285-94 pubmed publisher
    ..Urine samples were collected before surgery and at median of five time points within 48 hours of bypass. Urine NGAL was quantified as absolute concentration, creatinine-normalized concentration, and absolute excretion rate, and a ..
  77. Tosse V, Pillekamp F, Verde P, Hadzik B, Sabir H, Mayatepek E, et al. Urinary NT-proBNP, NGAL, and H-FABP may predict hemodynamic relevance of patent ductus arteriosus in very low birth weight infants. Neonatology. 2012;101:260-6 pubmed publisher
    ..Urinary protein levels of NT-proBNP, NGAL, and H-FABP were measured and correlated with the necessity of therapy for PDA...
  78. Virzì G, Clementi A, De Cal M, Cruz D, Ronco C. Genomics and biological activity of neutrophil gelatinase-associated lipocalin in several clinical settings. Blood Purif. 2013;35:139-43 pubmed publisher
    Recent literature has shown that neutrophil gelatinase-associated lipocalin (NGAL) is one of the most interesting and promising biomarkers in case of acute kidney injury...
  79. Ong K, Tso A, Cherny S, Sham P, Lam T, Lam K, et al. Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure. Clin Exp Hypertens. 2011;33:484-91 pubmed publisher
    ..investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding lipocalin-2 (LCN2) with elevated blood pressure (BP) in Hong Kong Chinese...
  80. Nauta F, Boertien W, Bakker S, van Goor H, van Oeveren W, de Jong P, et al. Glomerular and tubular damage markers are elevated in patients with diabetes. Diabetes Care. 2011;34:975-81 pubmed publisher
    ..kidney injury molecule [KIM]-1, N-acetyl-?-d-glucosaminidase [NAG], neutrophil gelatinase-associated lipocalin [NGAL], and cystatin C), and distal tubular (heart fatty acid-binding protein [H-FABP]) damage markers with kidney ..
  81. Roudkenar M, Halabian R, Roushandeh A, Nourani M, Masroori N, Ebrahimi M, et al. Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses. Exp Cell Res. 2009;315:3140-51 pubmed publisher
    ..Lipocalin 2 (Lcn2/NGAL) is expressed in various normal and pathologic conditions...
  82. Provatopoulou X, Gounaris A, Kalogera E, Zagouri F, Flessas I, Goussetis E, et al. Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease. BMC Cancer. 2009;9:390 pubmed publisher
    Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9) is correlated with cancer disease ..
  83. Makris K, Markou N, Evodia E, Dimopoulou E, Drakopoulos I, Ntetsika K, et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. Clin Chem Lab Med. 2009;47:79-82 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL), an iron-transporting protein rapidly accumulating in the kidney tubules and urine after nephrotoxic and ischemic insults, has been put forward as an early, sensitive, non-invasive ..
  84. Martí J, Fuster J, Hotter G, Solà A, Deulofeu R, Modolo M, et al. Serum neutrophil gelatinase-associated lipocalin in patients with colorectal liver metastases: preliminary results of an exploratory prospective study. Int J Biol Markers. 2010;25:21-6 pubmed
    To quantify preoperative serum neutrophil gelatinase-associated lipocalin (NGAL) levels in patients undergoing curative resection of colorectal liver metastases and to assess the relationship between NGAL levels and prognostic features in ..
  85. Barresi V, Reggiani Bonetti L, Di Gregorio C, Vitarelli E, Ponz de Leon M, Barresi G. Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma. Pathol Res Pract. 2011;207:479-86 pubmed publisher
    The expression of neutrophil gelatinase-associated lipocalin (NGAL) has been suggested to behave like a negative prognostic marker in stage I colorectal carcinoma...
  86. Liu M, Jin T, SHEN J, Shen Z, Zheng Z, Zhang Z, et al. NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis. J Neurooncol. 2011;104:119-27 pubmed publisher
    Recently, neutrophil gelatinase-associated lipocalin (NGAL) and its cell surface receptor, NGALR, have been shown to have critical roles in the biology of various tumors...