LBR

Summary

Gene Symbol: LBR
Description: lamin B receptor
Alias: DHCR14B, LMN2R, PHA, TDRD18, lamin-B receptor, integral nuclear envelope inner membrane protein, tudor domain containing 18
Species: human
Products:     LBR

Top Publications

  1. Worman H, Yuan J, Blobel G, Georgatos S. A lamin B receptor in the nuclear envelope. Proc Natl Acad Sci U S A. 1988;85:8531-4 pubmed
    ..We demonstrate that a 58-kDa integral membrane protein (p58) is a lamin B receptor by virtue of its abundance in the nuclear envelope and association with 125I-labeled lamin B in ligand ..
  2. Soullam B, Worman H. The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal. J Cell Biol. 1993;120:1093-100 pubmed
    The lamin B receptor (LBR) is a polytopic protein of the inner nuclear membrane...
  3. Ye Q, Worman H. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J Biol Chem. 1994;269:11306-11 pubmed
    ..Human LBR is 68% identical to the chicken lamin B receptor and has a basic nucleoplasmic amino-terminal domain of 208 amino acids followed by a hydrophobic domain with ..
  4. Pyrpasopoulou A, Meier J, Maison C, Simos G, Georgatos S. The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J. 1996;15:7108-19 pubmed
    ..we have arrived at the conclusion that the principal chromatin anchorage site at the nuclear envelope is the lamin B receptor (LBR), a ubiquitous integral protein of the inner nuclear membrane...
  5. Ye Q, Callebaut I, Pezhman A, Courvalin J, Worman H. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J Biol Chem. 1997;272:14983-9 pubmed
    HP1-type chromodomain proteins self-associate as well as interact with the inner nuclear membrane protein LBR (lamin B receptor) and transcriptional coactivators TIF1alpha and TIF1beta...
  6. Takano M, Takeuchi M, Ito H, Furukawa K, Sugimoto K, Omata S, et al. The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region. Eur J Biochem. 2002;269:943-53 pubmed
    Binding of lamin B receptor (LBR) to chromatin was studied by means of an in vitro assay system involving recombinant fragments of human LBR and Xenopus sperm chromatin...
  7. Dreger C, König A, Spring H, Lichter P, Herrmann H. Investigation of nuclear architecture with a domain-presenting expression system. J Struct Biol. 2002;140:100-15 pubmed
    ..domain of the lamin B tail, the entire lamin B tail, the amino-terminal nucleoplasmic segment of the lamin B receptor (LBR), and the LEM domain of emerin, respectively...
  8. Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, et al. Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J Biol Chem. 2004;279:13265-71 pubmed
    Participation of multiple kinases in regulation of the binding of lamin B receptor (LBR) to chromatin was suggested previously (Takano, M., Takeuchi, M., Ito, H., Furukawa, K., Sugimoto, K., Omata, S., and Horigome, T. (2002) Eur. J...
  9. Lu X, Shi Y, Lu Q, Ma Y, Luo J, Wang Q, et al. Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit. J Biol Chem. 2010;285:33281-93 pubmed publisher
    b>Lamin B receptor (LBR), a chromatin and lamin B-binding protein in the inner nuclear membrane, has been proposed to target the membrane precursor vesicles to chromatin mediated by importin ? during the nuclear envelope (NE) assembly...

More Information

Publications126 found, 100 shown here

  1. Holmer L, Pezhman A, Worman H. The human lamin B receptor/sterol reductase multigene family. Genomics. 1998;54:469-76 pubmed
    LBR (lamin B receptor) is an integral protein of the inner nuclear membrane encoded by a gene on human chromosome 1q42.1...
  2. Martins S, Eide T, Steen R, Jahnsen T, Skålhegg B S, Collas P. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. J Cell Sci. 2000;113 Pt 21:3703-13 pubmed
    ..HA95 resides in a complex together with lamin B receptor (LBR), lamina-associated polypeptide (LAP)2 and emerin, integral proteins of the inner nuclear membrane...
  3. Hoffmann K, Dreger C, Olins A, Olins D, Shultz L, Lucke B, et al. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). Nat Genet. 2002;31:410-4 pubmed
    ..We identified four splice-site, two frameshift and two nonsense mutations in LBR, encoding the lamin B receptor. The lamin B receptor (LBR), a member of the sterol reductase family, is evolutionarily conserved and ..
  4. Waterham H, Koster J, Mooyer P, Noort Gv G, Kelley R, Wilcox W, et al. Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene. Am J Hum Genet. 2003;72:1013-7 pubmed
    ..identified a homozygous 1599-1605TCTTCTA-->CTAGAAG substitution in exon 13 of the LBR gene encoding the lamin B receptor, which results in a truncated protein...
  5. Best S, Salvati F, Kallo J, Garner C, Height S, Thein S, et al. Lamin B-receptor mutations in Pelger-Huët anomaly. Br J Haematol. 2003;123:542-4 pubmed
    ..Following linkage studies in two families, the lamin B-receptor (LBR) was sequenced and mutations found: CCG-->CTG causing proline-->leucine in codon 119 of exon 3, and IVS11-9 A-..
  6. Guarda A, Bolognese F, Bonapace I, Badaracco G. Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2. Exp Cell Res. 2009;315:1895-903 pubmed publisher
    ..In this paper, we show that MeCP2 interacts in vitro and in vivo with the inner nuclear membrane protein LBR and that the unstructured aminoacidic sequence linking the MBD and TRD domains of MeCP2 is responsible for this ..
  7. Kamath M, Maheshwari A, Bhattacharya S, Lor K, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. Cochrane Database Syst Rev. 2017;11:CD008528 pubmed publisher
    ..We included randomized controlled trials (RCTs). The primary outcomes were live-birth rate (LBR) and OHSS. Three review authors independently assessed trial eligibility and risk of bias...
  8. Wang T, Johansson P, Abós B, Holt A, Tafalla C, Jiang Y, et al. First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities. Oncotarget. 2016;7:10917-46 pubmed publisher
    ..and during proliferative kidney disease (PKD) in vivo, and by formalin-killed bacteria, PAMPs, the T cell mitogen PHA, and the T-cell cytokines IL-2 and IL-21 in vitro...
  9. Suzuki O, Abe M, Hashimoto Y. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47:2091-9 pubmed publisher
    ..inhibitor, tunicamycin (TM) inhibited the surface expression of Phaseolus vulgaris leukoagglutinating (L-PHA) lectin- and Canavalia ensiformis (ConA) lectin-reactive oligosaccharides in the HBL-8 cell line...
  10. Hanukoglu I, Boggula V, Vaknine H, Sharma S, KLEYMAN T, Hanukoglu A. Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages. Histochem Cell Biol. 2017;147:733-748 pubmed publisher
    ..Mutations in ENaC subunit genes lead to a severe multi-system (systemic) form of pseudohypoaldosteronism (PHA) type I, characterized by salt loss from aldosterone target organs, including sweat glands in the skin...
  11. Das R, Melo J, Thondamal M, Morton E, Cornwell A, Crick B, et al. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. PLoS Genet. 2017;13:e1007038 pubmed publisher
    ..The autophagy-stimulating transcription factors pha-4/FoxA and mxl-2/Mlx, but not hlh-30/TFEB or the nuclear hormone receptor nhr-62, are necessary for extended ..
  12. Singh N, Johnstone D, Martin K, Tempera I, Kaplan M, Denny M. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech. 2016;9:885-97 pubmed publisher
    ..the Pelger-Huet anomaly, and had prominent mis-splicing of mRNA encoding the nuclear membrane protein lamin B receptor (LBR), consistent with their Pelger-Huet-like nuclear morphology, we used a novel mouse model system to test ..
  13. Canonica J, Sergi C, Maillard M, Klusonova P, Odermatt A, Koesters R, et al. Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype. Pflugers Arch. 2016;468:895-908 pubmed publisher
    ..mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia, ..
  14. Upala P, Apidechkul T, Suttana W, Kullawong N, Tamornpark R, Inta C. Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study. BMC Infect Dis. 2018;18:630 pubmed publisher
    ..Participants were recruited from 14 hospitals in two provinces in northern Thailand, specifically, Chiang Rai and Pha Yao Province, between January 1, 2016, and December 31, 2016...
  15. Tiwarekar V, Wohlfahrt J, Fehrholz M, Scholz C, Kneitz S, Schneider Schaulies J. APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition. J Virol. 2018;92: pubmed publisher
    ..peripheral blood lymphocytes (PBL), expression of A3G and REDD1 was found to be stimulated by phytohemagglutinin (PHA) and interleukin-2...
  16. Busnelli A, Paffoni A, Fedele L, Somigliana E. The impact of thyroid autoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis. Hum Reprod Update. 2016;22:775-790 pubmed
    ..The primary outcome was live birth rate (LBR)...
  17. Wirleitner B, Okhowat J, Vistejnova L, Kralickova M, Karlíková M, Vanderzwalmen P, et al. Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval. Ultrasound Obstet Gynecol. 2018;51:118-125 pubmed publisher
    ..Clinical outcome, in terms of implantation rate, (clinical) pregnancy rate, miscarriage and live-birth rate (LBR), was evaluated...
  18. Buxboim A, Irianto J, Swift J, Athirasala A, Shin J, Rehfeldt F, et al. Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes. Mol Biol Cell. 2017;28:3333-3348 pubmed publisher
    ..MSCs further show that lamin-A,C's increase with tissue or matrix stiffness anti-correlates with lamin-B receptor (LBR), which contributes to lipid/sterol biosynthesis...
  19. Al Attas A, El Shaer N, Mohamed G, Ibrahim S, Esmat A. Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes. J Ethnopharmacol. 2015;176:365-74 pubmed publisher
    ..Compounds 5 and 6 did not significantly decrease levels of different cytokines, PGE2, lipoxgenase-5, and COX-2 from PHA treatment at 1 µM...
  20. Mu P, Wang Y, Ao J, Ai C, Chen X. Molecular cloning and bioactivity of an IL-2 homologue in large yellow croaker (Larimichthys crocea). Fish Shellfish Immunol. 2018;81:309-317 pubmed publisher
    ..addition, the expression level of LcIL-2 in PKL was slightly induced by LPS or poly(I:C), while markedly induced by PHA or Con-A...
  21. Zasonska B, Liskova A, Kuricova M, Tulinska J, Pop Georgievski O, Ciampor F, et al. Functionalized porous silica&maghemite core-shell nanoparticles for applications in medicine: design, synthesis, and immunotoxicity. Croat Med J. 2016;57:165-78 pubmed
    ..in the cells treated with 3, 15, and 75 µg of particles/cm2 for 48 h and stimulated with pokeweed mitogen (PHA). No significant changes in TNF-α and IFN-γ production were observed...
  22. Gitoee A, Sadeghi G, Karimi A. Combination Effects of Organic and Inorganic Chromium on Production Performance, Reproductive Response, Immune Status, and Maternal Antibody Transmission in Breeder Quails Under Heat Stress. Biol Trace Elem Res. 2018;184:508-516 pubmed publisher
    ..Cell-mediated immunity was assessed by the cutaneous basophil hypersensitivity (CBH) test to phytohemagglutinin (PHA) at days 20 and 45 of age...
  23. Wei X, Zhao T, Ai K, Zhang Y, Li H, Yang J. c-Raf participates in adaptive immune response of Nile tilapia via regulating lymphocyte activation. Fish Shellfish Immunol. 2019;86:507-515 pubmed publisher
    ..On-c-Raf mRNA in leukocytes of Nile tilapias was obviously induced by in vitro stimulation of T cell mitogen PHA. More importantly, in vitro stimulation of lymphocytes agonist PMA augmented phosphorylation level of On-c-Raf in ..
  24. Smet Nocca C, Page A, Cantrelle F, Nikolakaki E, Landrieu I, Giannakouros T. The O-?-linked N-acetylglucosaminylation of the Lamin B receptor and its impact on DNA binding and phosphorylation. Biochim Biophys Acta Gen Subj. 2018;1862:825-835 pubmed publisher
    b>Lamin B Receptor (LBR) is an integral protein of the interphase inner nuclear membrane that is implicated in chromatin anchorage to the nuclear envelope...
  25. Lattes K, Checa M, Vassena R, Brassesco M, Vernaeve V. There is no evidence that the time from egg retrieval to embryo transfer affects live birth rates in a freeze-all strategy. Hum Reprod. 2017;32:368-374 pubmed publisher
    ..Differences were considered significant if P < 0.05. Live birth rate (LBR) was significantly higher in FET performed during Cycle 1 vs Cycle ≥2 (37.6% vs 27.3%, respectively; P = 0...
  26. Xu D, Hu X, Tian Y. Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis). J Exp Biol. 2017;220:2187-2195 pubmed publisher
    ..immunity, and did not affect the mass of the thymus and spleen, intermediate granulocytes, the phytohaemagglutinin (PHA) response and the levels of blood glucose and serum leptin...
  27. Huang X, Su S, Duan J, Sha X, Zhu K, Guo J, et al. Effects and mechanisms of Shaofu-Zhuyu decoction and its major bioactive component for Cold - Stagnation and Blood - Stasis primary dysmenorrhea rats. J Ethnopharmacol. 2016;186:234-243 pubmed publisher
    ..In this present study the metabolomics of CSBS primary dysmenorrhea diseased rats and the cytokine transcription in PHA stimulated-PBMC were investigated to explore the effects and mechanisms...
  28. Jambunathan P, Zhang K. Engineered biosynthesis of biodegradable polymers. J Ind Microbiol Biotechnol. 2016;43:1037-58 pubmed publisher
    ..view on the recent developments of three promising biobased plastics, polylactic acid (PLA), polyhydroxyalkanoate (PHA) and polybutylene succinate (PBS), well known for their biodegradability...
  29. Mezzina M, Pettinari M. Phasins, Multifaceted Polyhydroxyalkanoate Granule-Associated Proteins. Appl Environ Microbiol. 2016;82:5060-7 pubmed publisher
    Phasins are the major polyhydroxyalkanoate (PHA) granule-associated proteins. They promote bacterial growth and PHA synthesis and affect the number, size, and distribution of the granules...
  30. Hindatu Y, Annuar M, Subramaniam R, Gumel A. Medium-chain-length poly-3-hydroxyalkanoates-carbon nanotubes composite anode enhances the performance of microbial fuel cell. Bioprocess Biosyst Eng. 2017;40:919-928 pubmed publisher
    ..In this study, medium-chain-length poly-3-hydroxyalkanoates (PHA)/carbon nanotubes (C) composite (CPHA) was successfully applied to modify the surface of carbon cloth (CC) anode in ..
  31. Abbondanzi F, Biscaro G, Carvalho G, Favaro L, Lemos P, Paglione M, et al. Fast method for the determination of short-chain-length polyhydroxyalkanoates (scl-PHAs) in bacterial samples by In Vial-Thermolysis (IVT). N Biotechnol. 2017;39:29-35 pubmed publisher
    ..IVT), allowed for the simultaneous determination of short-chain-length polyhydroxyalkanoates (scl-PHA) content and composition...
  32. Huang H, Su W, Chiang C, Feng J, Huang H, Lin C, et al. The predictive value of the interferon-γ release assay for chemotherapy responses in patients with advanced non-small-cell lung cancer. Lung Cancer. 2018;115:64-70 pubmed publisher
    ..Our previous study had showed an association between phytohemagglutinin (PHA)-stimulated IFN-γ (PSIG) response and overall survival in patients with advanced non-small-cell lung cancer (NSCLC)..
  33. Wazir U, Ahmed M, Bridger J, Harvey A, Jiang W, Sharma A, et al. The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer. Cell Mol Biol Lett. 2013;18:595-611 pubmed publisher
    Lamin A/C (LMNA), lamin B1 (LMNB1) and lamin B receptor (LBR) have key roles in nuclear structural integrity and chromosomal stability...
  34. Roessler J, Olivera F, Wasman S, Townsend T, McVay M, Ferraro C, et al. Construction material properties of slag from the high temperature arc gasification of municipal solid waste. Waste Manag. 2016;52:169-79 pubmed publisher
    ..04kN/m(3)) greater than conventionally used aggregates and WTE BA. The LBR tests demonstrated a substantial bearing capacity (>200)...
  35. Konieczka P, Barszcz M, Chmielewska N, Cieslak M, Szlis M, Smulikowska S. Interactive effects of dietary lipids and vitamin E level on performance, blood eicosanoids, and response to mitogen stimulation in broiler chickens of different ages. Poult Sci. 2017;96:359-369 pubmed publisher
    ..DHA) and arachidonic acid (AA) into immune tissues, and changes in leukocyte population after phytohemagglutinin (PHA) challenge were investigated in broiler chickens of different ages...
  36. Cibichakravarthy B, Abinaya S, Prabagaran S. Syntrophic association of termite gut bacterial symbionts with bifunctional characteristics of cellulose degrading and polyhydroxyalkanoate producing bacteria. Int J Biol Macromol. 2017;103:613-620 pubmed publisher
    ..were made worldwide with a quest for identifying viable important biological macromolecule polyhydroxyalkanoate (PHA) accumulating bacteria...
  37. Kushnir V, Choi J, Darmon S, Albertini D, Barad D, Gleicher N. CDC-reported assisted reproductive technology live-birth rates may mislead the public. Reprod Biomed Online. 2017;35:161-164 pubmed publisher
    ..Centre for Disease Control and Prevention (CDC) publicly reports assisted reproductive technology live-birth rates (LBR) for each US fertility clinic under legal mandate. The 2014 CDC report excluded 35,406 of 184,527 (19...
  38. Yan B, Selvam A, Wong J. Influence of acidogenic headspace pressure on methane production under schematic of diversion of acidogenic off-gas to methanogenic reactor. Bioresour Technol. 2017;245:1000-1007 pubmed publisher
    ..3psi (T3) and ambient (T4) headspace pressure on the metabolic pathways in the acidogenic leach bed reactor (LBR) and overall methane recovery during two-phase anaerobic digestion of food waste...
  39. Gupta A, Unadkat J, Mao Q. Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP). J Pharm Sci. 2007;96:3226-35 pubmed
    ..on BCRP efflux activity in BCRP-overexpressing HEK cells was determined by measuring intracellular pheophorbide A (PhA) fluorescence using flow cytometry...
  40. Huong K, Kannusamy S, Lim S, Amirul A. Biosynthetic enhancement of single-stage Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production by manipulating the substrate mixtures. J Ind Microbiol Biotechnol. 2015;42:1291-7 pubmed publisher
    ..Studies on bioreactor scale show a remarkably high PHA accumulation of 73 wt%, contributing to a high PHA concentration and product yield of 8.6 g/L and 2...
  41. Chanasit W, Hodgson B, Sudesh K, Umsakul K. Efficient production of polyhydroxyalkanoates (PHAs) from Pseudomonas mendocina PSU using a biodiesel liquid waste (BLW) as the sole carbon source. Biosci Biotechnol Biochem. 2016;80:1440-50 pubmed publisher
    Conditions for the optimal production of polyhydroxyalkanoate (PHA) by Pseudomonas mendocina PSU using a biodiesel liquid waste (BLW) were determined by response surface methodology...
  42. Madapura H, Salamon D, Wiman K, Lain S, Klein E, Nagy N. cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response. Cell Cycle. 2016;15:1267-75 pubmed publisher
    ..We show here that kinetics of proliferation of PHA activated T cells follows the expression of cMyc...
  43. Rebouissou S, La Bella T, Rekik S, Imbeaud S, Calatayud A, Rohr Udilova N, et al. Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity In Vitro. Clin Cancer Res. 2017;23:4364-4375 pubmed publisher
    ..b>Experimental Design: Sensitivity to tivantinib, JNJ-38877605, PHA-665752, vinblastine, and paclitaxel was tested in a panel of 35 liver cancer cell lines analyzed with exome ..
  44. Deniz R, Tulunay Virlan A, Türe Ozdemir F, Ünal A, Ozen G, Alibaz Oner F, et al. Th17-Inducing Conditions Lead to in vitro Activation of Both Th17 and Th1 Responses in Behcet's Disease. Immunol Invest. 2017;46:518-525 pubmed publisher
    ..1 ± 9.3 years), were cultured in Th17-inducing conditions (IL-6, Phytohemagglutinin (PHA), IL-1β, and IL-23) for 6 days...
  45. Saratale G, Oh M. Characterization of poly-3-hydroxybutyrate (PHB) produced from Ralstonia eutropha using an alkali-pretreated biomass feedstock. Int J Biol Macromol. 2015;80:627-35 pubmed publisher
    ..It is noteworthy that dry cell weight, polyhydroxyalkanoate (PHA) accumulation and PHB yield with the use of laboratory-grade sugars were similar to those achieved with PS-derived ..
  46. Cruikshank M, Anoop P, Nikolajeva O, Rao A, Rao K, Gilmour K, et al. Screening assays for primary haemophagocytic lymphohistiocytosis in children presenting with suspected macrophage activation syndrome. Pediatr Rheumatol Online J. 2015;12 Suppl 1:48 pubmed publisher
    ..expression of perforin in CD56+ Natural Killer (NK) cells; CD107a Granule Release Assay (GRA) in response to PHA in NK cells, or anti-CD3 stimulation of CD8 lymphocytes; in males Signal Lymphocyte Activating Molecule Associated ..
  47. Hwang J, Lee E, Kim J, Seo Y, Lee K, Hong J, et al. Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles. Colloids Surf B Biointerfaces. 2016;142:290-296 pubmed publisher
    ..the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA)...
  48. Charntikov S, Falco A, Fink K, Dwoskin L, Bevins R. The effect of sazetidine-A and other nicotinic ligands on nicotine controlled goal-tracking in female and male rats. Neuropharmacology. 2017;113:354-366 pubmed publisher
    ..stimulus was assessed using substitution and targeted combination tests with the following ligands: sazetidine-A, PHA-543613, PNU-120596, bupropion, nornicotine, and cytisine...
  49. Roux P, Perrin J, Mancini J, Agostini A, Boubli L, Courbiere B. Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis. J Assist Reprod Genet. 2017;34:921-928 pubmed publisher
    To assess the factors associated with a poor prognosis for a cumulative IVF live birth rate (LBR) in women with stage III and IV endometriosis according to the revised classification of the American Fertility Society (rAFS)...
  50. Beliakova Bethell N, Hezareh M, Wong J, Strain M, Lewinski M, Richman D, et al. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017;508:127-133 pubmed publisher
    ..this end, we compared four commonly used T cell stimuli: 1) irradiated allogeneic cells plus phytohaemagglutinin (PHA); 2) PHA alone; 3) phorbol myristate acetate plus Ionomycin; and 4) immobilized αCD3 plus αCD28 antibodies...
  51. Shin Y, Yoon C, Lim H, Park J, Roh T, Kang C, et al. Impaired IL-2 expression in latent HIV-1 infection. Biochem Biophys Res Commun. 2015;463:1237-42 pubmed publisher
    ..for mRNA expression and enzyme-linked immunosorbent assay (ELISA) for levels of IL-2 in phytohemagglutinin M (PHA-M)...
  52. Visseaux B, Charpentier C, Collin G, Bertine M, Peytavin G, Damond F, et al. Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates. PLoS ONE. 2015;10:e0134904 pubmed publisher
    ..All isolates were obtained by co-cultivation of PHA-activated PBMC from distinct HIV-2-infected CCR5-antagonist-naïve patients included in the French HIV-2 cohort ..
  53. Kiire S. Effect of Leg-to-Body Ratio on Body Shape Attractiveness. Arch Sex Behav. 2016;45:901-10 pubmed publisher
    ..of the legs is an often-emphasized aspect of attractiveness and has been investigated using the leg-to-body ratio (LBR), which reflects nutritional status of the infant, health status, fecundity, and other factors that are predictive ..
  54. Wang Y, Sun T, Gao X, Shi M, Wu L, Chen L, et al. Biosynthesis of platform chemical 3-hydroxypropionic acid (3-HP) directly from CO2 in cyanobacterium Synechocystis sp. PCC 6803. Metab Eng. 2016;34:60-70 pubmed publisher
    ..NAD(P) transhydrogenase gene; iv) directing more carbon flux into 3-HP by inactivating the competing pathways of PHA and acetate biosynthesis. Together, the efforts led to a production of 837.18 mg L(-1) (348...
  55. Funston S, Tsaousi K, Smyth T, Twigg M, Marchant R, Banat I. Enhanced rhamnolipid production in Burkholderia thailandensis transposon knockout strains deficient in polyhydroxyalkanoate (PHA) synthesis. Appl Microbiol Biotechnol. 2017;101:8443-8454 pubmed publisher
    ..thailandensis through mutation of genes responsible for the synthesis of the storage material polyhydroxyalkanoate (PHA), thereby increasing cellular resources for the production of rhamnolipids...
  56. Huang L, Chen Z, Wen Q, Zhao L, Lee D, Yang L, et al. Insights into Feast-Famine polyhydroxyalkanoate (PHA)-producer selection: Microbial community succession, relationships with system function and underlying driving forces. Water Res. 2018;131:167-176 pubmed publisher
    The Feast-Famine (FF) process has been frequently used to select polyhydroxyalkanoate (PHA)-accumulating mixed cultures (MCs), but there has been little insight into the ecophysiology of the microbial community during the selection ..
  57. Hooks D, Rehm B. Insights into the surface topology of polyhydroxyalkanoate synthase: self-assembly of functionalized inclusions. Appl Microbiol Biotechnol. 2015;99:8045-53 pubmed publisher
    The polyhydroxyalkanoate (PHA) synthase catalyzes the synthesis of PHA and remains attached to the hydrophobic PHA inclusions it creates...
  58. Aldea M, Barallat J, Martín M, Rosas I, Pastor M, Granada M. Sodium interference in the determination of urinary aldosterone. Clin Biochem. 2016;49:295-7 pubmed publisher
    Primary hyperaldosteronism (PHA) is one of the most common endocrine forms of secondary hypertension. Among the most used confirmatory tests for PHA is urinary aldosterone determination after oral sodium loading test...
  59. Khan K, Mesaik M, Abdalla O, Rahim F, Soomro S, Halim S, et al. The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies. Bioorg Chem. 2016;64:21-8 pubmed publisher
    ..Eight compounds (2, 4, 5, 8-10, 12, and 18) showed potent inhibitory activity on PHA-activated peripheral blood mononuclear cells (PBMCs) with IC50 ranging from 3.7 to 11...
  60. Wosman A, Lu Y, Sun S, Liu X, Wan C, Zhang Y, et al. Effect of operational strategies on activated sludge's acclimation to phenol, subsequent aerobic granulation, and accumulation of polyhydoxyalkanoates. J Hazard Mater. 2016;317:221-228 pubmed publisher
    ..In addition, the content of intracellular polyhydoxyakanoates (PHA) was also monitored, and significant accumulation was observed during the pre-granulation stage, where PHA >50% ..
  61. Polasky C, Weigend S, Schrader L, Berndt A. Non-specific activation of CD8?-characterised ?? T cells in PBL cultures of different chicken lines. Vet Immunol Immunopathol. 2016;179:1-7 pubmed publisher
    ..different chicken lines (WLA, BLA, R11, L68) were treated with a range of commonly used non-specific reagents (PMA, PHA, ConA) and interleukins (IL-2, IL-12, IL-15), and the CD8?(-), CD8?(hi)?(+) and CD8??(hi+) ?? T-cell subsets ..
  62. Erdem E, Karacan M, Usta A, Arvas A, Cebi Z, Camlibel T. Outcome of ICSI with motile testicular spermatozoa obtained through microscopically assisted testicular sperm extraction in relation to the ovarian response. J Gynecol Obstet Hum Reprod. 2017;46:405-410 pubmed publisher
    ..to analyze relationship between the AFC, basal FSH, woman's age, the number of oocytes, and the live birth rate (LBR)...
  63. Tsuge T, Sato S, Hiroe A, Ishizuka K, Kanazawa H, Shiro Y, et al. Contribution of the distal pocket residue to the acyl-chain-length specificity of (R)-specific enoyl-coenzyme A hydratases from Pseudomonas spp. Appl Environ Microbiol. 2015;81:8076-83 pubmed publisher
    ..hydratases (PhaJs) are capable of supplying monomers from fatty acid β-oxidation to polyhydroxyalkanoate (PHA) biosynthesis...
  64. Bresan S, Sznajder A, Hauf W, Forchhammer K, Pfeiffer D, Jendrossek D. Polyhydroxyalkanoate (PHA) Granules Have no Phospholipids. Sci Rep. 2016;6:26612 pubmed publisher
    ..same result was obtained for Pseudomonas putida, a species that accumulates another type of polyhydroxyalkanoate (PHA) granules related to PHB...
  65. Tajima K, Han X, Hashimoto Y, Satoh Y, Satoh T, Taguchi S. In vitro synthesis of polyhydroxyalkanoates using thermostable acetyl-CoA synthetase, CoA transferase, and PHA synthase from thermotorelant bacteria. J Biosci Bioeng. 2016;122:660-665 pubmed publisher
    Thermostable enzymes are required for the rapid and sustainable production of polyhydroxyalkanoate (PHA) in vitro...
  66. Bengtsson S, Karlsson A, Alexandersson T, Quadri L, Hjort M, Johansson P, et al. A process for polyhydroxyalkanoate (PHA) production from municipal wastewater treatment with biological carbon and nitrogen removal demonstrated at pilot-scale. N Biotechnol. 2017;35:42-53 pubmed publisher
    ..83% removal) and total nitrogen (80% removal) while producing a biomass that was able to accumulate up to 49% PHA of volatile suspended solids with acetic acid or fermented organic residues as substrates...
  67. García Niño W, Estrada Muñiz E, Valverde M, Reyes Chilpa R, Vega L. Cytogenetic effects of Jacareubin from Calophyllum brasiliense on human peripheral blood mononucleated cells in vitro and on mouse polychromatic erythrocytes in vivo. Toxicol Appl Pharmacol. 2017;335:6-15 pubmed publisher
    ..Jacareubin (0.5-1000?M in DMSO) was more cytotoxic on phytohemagglutinin (PHA)-stimulated normal human peripheral blood mononuclear cells (PBMCs; IC50 at 72h by MTT: 85...
  68. Diaz Garcia C, Domingo J, Garcia Velasco J, Herraiz S, Mirabet V, Iniesta I, et al. Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study. Fertil Steril. 2018;109:478-485.e2 pubmed publisher
    ..OV using the cryotop device and OCT using a slow freezing protocol. Live-birth rate (LBR) and clinical pregnancy rate (CPR)...
  69. Zhang Q, Liu X, Wang X, Wang J, Li Q, Yang L, et al. [Amplification Ex Vivo and Cytocidal Activity of Leukemia Tumor-Associated Antigen-Specific Cytotoxic T Lymphocytes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:814-20 pubmed publisher
    ..assay was used to evaluate the cytotoxic activity of TAA-CTL against peptide-pulsed autologous target cells (PHA-Blasts). TAA-CTL expanded from volunteer showed a mean expansion of 3.81±1...
  70. Setiadi T, Aznury M, Trianto A, Pancoro A. Production of polyhydroxyalkanoate (PHA) by Ralstonia eutropha JMP 134 with volatile fatty acids from palm oil mill effluent as precursors. Water Sci Technol. 2015;72:1889-95 pubmed publisher
    ..Polyhydroxyalkanoate (PHA) production with VFAs from POME as precursors in the fed-batch mode has advantages over batch mode, both in terms ..
  71. Wu F, Lu W, Shang Y, Kong H, Li L, Sui Y, et al. Combined effects of seawater acidification and high temperature on hemocyte parameters in the thick shell mussel Mytilus coruscus. Fish Shellfish Immunol. 2016;56:554-562 pubmed publisher
    ..Generally, the total hemocyte count (THC), phagocytosis (Pha), esterase (Est), and lysosomal content (Lyso) significantly decreased at high temperature...
  72. Gaudy Marqueste C, Boyer A, Navarro C, Rouzier C, Harley J, Weiller P, et al. LMNA, ZMPSTE24, and LBR are not mutated in scleroderma. Genet Test Mol Biomarkers. 2009;13:635-9 pubmed publisher
    ..encoding A-type lamins; ZMPSTE24, encoding a protease involved in lamin A processing; and LBR, encoding the lamin B receptor. No mutation was retrieved, whereas 25 polymorphic sequence variations were identified, 7 of which were ..
  73. Tsai P, Zhao C, Turner E, Schlieker C. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. elife. 2016;5: pubmed publisher
    b>Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis...
  74. Lee J, Parlane N, Rehm B, Buddle B, Heiser A. Engineering Mycobacteria for the Production of Self-Assembling Biopolyesters Displaying Mycobacterial Antigens for Use as a Tuberculosis Vaccine. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Recently, engineered polyhydroxyalkanoate (PHA) biobeads that were produced in both Escherichia coli and Lactococcus lactis and displayed ..
  75. Matsumoto M, Wakiyama S, Shiba H, Ishida Y, Kita Y, Yanaga K. Usefulness of three-dimensional image navigation system for evaluation of hepatic artery before living donor liver transplantation: a case report. Surg Case Rep. 2017;3:87 pubmed publisher
    ..III, and IV arteries (A2, A3, and A4, respectively) that individually originated from the proper hepatic artery (PHA); this could not be detected by 3D CT angiography...
  76. Koller M, Dias M, Rodriguez Contreras A, Kunaver M, Zagar E, Krzan A, et al. Liquefied Wood as Inexpensive Precursor-Feedstock for Bio-Mediated Incorporation of (R)-3-Hydroxyvalerate into Polyhydroxyalkanoates. Materials (Basel). 2015;8:6543-6557 pubmed publisher
    ..inexpensive precursor feedstock for incorporation of (R)-3-hydroxyvalerate (3HV) into polyhydroxyalkanoate (PHA) biopolyesters in order to improve the biopolyester's material quality; Cupriavidus necator was applied as ..
  77. Zséli G, Vida B, Szilvásy Szabó A, Tóth M, Lechan R, Fekete C. Neuronal connections of the central amygdalar nucleus with refeeding-activated brain areas in rats. Brain Struct Funct. 2018;223:391-414 pubmed publisher
    ..elucidated using retrograde (cholera toxin-β subunit, CTB) and anterograde (phaseolus vulgaris leucoagglutinin, PHA-L) tracers in male rats. C-Fos-immunoreactivity was used as marker of neuronal activation...
  78. Arias A, Pérez Vélez C, Orrego J, Moncada Velez M, Rojas J, Wilches A, et al. Severe Enteropathy and Hypogammaglobulinemia Complicating Refractory Mycobacterium tuberculosis Complex Disseminated Disease in a Child with IL-12R?1 Deficiency. J Clin Immunol. 2017;37:732-738 pubmed publisher
    ..records and performed flow cytometry staining for lymphocyte populations, lymphocyte proliferation in response to PHA, and intracellular IFN-? production in T cell PHA blasts in the patient and a healthy control...
  79. Miranda De Sousa Dias M, Koller M, Puppi D, Morelli A, Chiellini F, Braunegg G. Fed-Batch Synthesis of Poly(3-Hydroxybutyrate) and Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) from Sucrose and 4-Hydroxybutyrate Precursors by Burkholderia sacchari Strain DSM 17165. Bioengineering (Basel). 2017;4: pubmed publisher
    ..metabolizing structurally related 3-hydroxyvalerate (3HV) precursors towards 3HV-containing polyhydroxyalkanoate (PHA) copolyester calls for alternatives...
  80. Malan M, Müller F, Raitt L, Cyster L, Brendonck L. Essential metal and metalloid elements in the Philippi Horticultural area, and their uptake into selected vegetable crops. Int J Phytoremediation. 2017;: pubmed publisher
    This study evaluated Co, Cr, Mn, Ni, Se, Sn and V status in the soils of the PHA, as well as the vegetables produced on these soils. We also determined the agronomic sources of these elements to the soils in the PHA...
  81. Versluys T, Skylark W. The effect of leg-to-body ratio on male attractiveness depends on the ecological validity of the figures. R Soc Open Sci. 2017;4:170399 pubmed publisher
    Leg-to-body ratio (LBR) predicts evolutionary fitness, and is therefore expected to influence bodily attractiveness...
  82. Chen G, Jiang X. Engineering microorganisms for improving polyhydroxyalkanoate biosynthesis. Curr Opin Biotechnol. 2018;53:20-25 pubmed publisher
    Biosynthesis of polyhydroxyalkanoates (PHA) has been studied since the 1920s. The biosynthesis pathways have been well understood and various attempts have been made to improve the PHA biosynthesis efficiency...
  83. Suwannapoom C, Yuan Z, Jiang K, Yan F, Gao W, Che J. A new species of rain-pool frog (Dicroglossidae: Fejervarya) from western Thailand. Zool Res. 2017;38:243-250 pubmed publisher
    ..nov., based on a series of specimens collected from Ban Tha Khanun, Thong Pha Phum District, Kanchanaburi Province, Thailand...
  84. Papoutsopoulou S, Nikolakaki E, Giannakouros T. SRPK1 and LBR protein kinases show identical substrate specificities. Biochem Biophys Res Commun. 1999;255:602-7 pubmed
    ..SR splicing factors that are essential for pre-mRNA splicing and the lamin B receptor (LBR), an integral protein of the inner nuclear membrane, are among the best characterized proteins that ..
  85. Lin V, Chen J, Liao C, Lee S, Chien E. The rapid immunosuppression in phytohemagglutinin-activated human T cells is inhibited by the proliferative Ca(2+) influx induced by progesterone and analogs. Steroids. 2016;111:71-78 pubmed publisher
    ..proliferation after crosslinking of T-cell receptor/CD3 complexes by anti-CD3 antibodies or phytohemagglutinin (PHA)...
  86. Shen N, Chen Y, Zhou Y. Multi-cycle operation of enhanced biological phosphorus removal (EBPR) with different carbon sources under high temperature. Water Res. 2017;114:308-315 pubmed publisher
    ..anaerobic and aerobic phases were higher at high temperature than low temperature (20±1 °C) except anaerobic PHA/C ratios within most of the sub-cycles...
  87. Baikar V, Rane A, Deopurkar R. Characterization of Polyhydroxyalkanoate Produced by Bacillus megaterium VB89 Isolated from Nisargruna Biogas Plant. Appl Biochem Biotechnol. 2017;183:241-253 pubmed publisher
    ..The bacterium producing highest yield of PHA (0.672 ± 0...
  88. Anis S, Mohamad Annuar M, Simarani K. In vivo and in vitro depolymerizations of intracellular medium-chain-length poly-3-hydroxyalkanoates produced by Pseudomonas putida Bet001. Prep Biochem Biotechnol. 2017;47:824-834 pubmed publisher
    In vivo and in vitro depolymerizations of intracellular medium-chain-length poly-3-hydroxyalkanoates (mcl-PHA) in Pseudomonas putida Bet001 grown on lauric acid was studied...
  89. Radecka I, Irorere V, Jiang G, Hill D, Williams C, Adamus G, et al. Oxidized Polyethylene Wax as a Potential Carbon Source for PHA Production. Materials (Basel). 2016;9: pubmed publisher
    We report on the ability of bacteria to produce biodegradable polyhydroxyalkanoates (PHA) using oxidized polyethylene wax (O-PEW) as a novel carbon source. The O-PEW was obtained in a process that used air or oxygen as an oxidizing agent...
  90. Hokamura A, Yunoue Y, Goto S, Matsusaki H. Biosynthesis of Polyhydroxyalkanoate from Steamed Soybean Wastewater by a Recombinant Strain of Pseudomonas sp. 61-3. Bioengineering (Basel). 2017;4: pubmed publisher
    ..i>Pseudomonas sp. 61-3 possesses two types of PHA synthases, PHB synthase (PhbC) and PHA synthases (PhaC1 and PhaC2), encoded by the phb and pha loci, ..
  91. Torri C, Weme T, Samorì C, Kiwan A, Brilman D. Renewable Alkenes from the Hydrothermal Treatment of Polyhydroxyalkanoates-Containing Sludge. Environ Sci Technol. 2017;51:12683-12691 pubmed publisher
    Polyhydroxyalkanoates (PHA) are a key constituent of excess sludge produced by Aerobic Sewage Sludge Treatment plants...
  92. Kumar P, Jun H, Kim B. Co-production of polyhydroxyalkanoates and carotenoids through bioconversion of glycerol by Paracoccus sp. strain LL1. Int J Biol Macromol. 2018;107:2552-2558 pubmed publisher
    Polyhydroxyalkanoates (PHA) have emerged as a potential alternative to synthetic plastics, although its large-scale production is limited by the expenditure incurred in feed materials...