LATS1

Summary

Gene Symbol: LATS1
Description: large tumor suppressor kinase 1
Alias: WARTS, wts, serine/threonine-protein kinase LATS1, LATS (large tumor suppressor, Drosophila) homolog 1, LATS, large tumor suppressor, homolog 1, WARTS protein kinase, h-warts, large tumor suppressor homolog 1
Species: human
Products:     LATS1

Top Publications

  1. St John M, Tao W, Fei X, Fukumoto R, Carcangiu M, Brownstein D, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999;21:182-6 pubmed
    ..Mosaic flies carrying somatic cells that are mutant for lats develop large tumours in many organs. The human LATS1 homologue rescues embryonic lethality and inhibits tumour growth in lats mutant flies, demonstrating the ..
  2. Hisaoka M, Tanaka A, Hashimoto H. Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. Lab Invest. 2002;82:1427-35 pubmed
    h-warts/LATS1 is a human homolog of the Drosophila warts tumor suppressor gene, which functions as a component of the mitotic apparatus...
  3. Oka T, Mazack V, Sudol M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem. 2008;283:27534-46 pubmed publisher
    ..Overexpression of YAP2 in HEK293 cells promoted apoptosis, whereas the Mst2/Lats1-induced phosphorylation of YAP partially rescued the cells from apoptotic death...
  4. Nishiyama Y, Hirota T, Morisaki T, Hara T, Marumoto T, Iida S, et al. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 1999;459:159-65 pubmed
    We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1...
  5. Zhang J, Smolen G, Haber D. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 2008;68:2789-94 pubmed publisher
    ..mammalian orthologs of Warts) interact directly with YAP in mammalian cells and that ectopic expression of LATS1, but not LATS2, effectively suppresses the YAP phenotypes...
  6. Hamilton G, Yee K, Scrace S, O Neill E. ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol. 2009;19:2020-5 pubmed publisher
    ..Ras association domain-containing family 1A (RASSF1A) promotes apoptosis by signaling through the MST2 and LATS1 kinases, leading to stabilization of the YAP1/p73 transcriptional complex...
  7. Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, et al. Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res. 2006;56:450-8 pubmed
    b>LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but their methylation statuses are still unknown in human astrocytoma...
  8. Chan E, Nousiainen M, Chalamalasetty R, Schäfer A, Nigg E, Sillje H. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene. 2005;24:2076-86 pubmed
    Originally identified in Drosophila melanogaster, the Warts(Wts)/Lats protein kinase has been proposed to function with two other Drosophila proteins, Hippo (Hpo) and Salvador (Sav), in the regulation of cell cycle exit and apoptosis...
  9. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..

More Information

Publications100

  1. Bothos J, Tuttle R, Ottey M, Luca F, Halazonetis T. Human LATS1 is a mitotic exit network kinase. Cancer Res. 2005;65:6568-75 pubmed
    The kinase LATS/WARTS is a tumor suppressor protein conserved in evolution, but its function at the molecular level is not well understood...
  2. Ho K, Zhou Z, She Y, Chun A, Cyr T, Yang X. Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]. Proc Natl Acad Sci U S A. 2011;108:4870-5 pubmed publisher
    The large tumor suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers...
  3. Xu T, Wang W, Zhang S, Stewart R, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 1995;121:1053-63 pubmed
    ..Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants. ..
  4. Yu F, Zhao B, Panupinthu N, Jewell J, Lian I, Wang L, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150:780-91 pubmed publisher
    ..and sphingosine 1-phosphophate (S1P) act through G12/13-coupled receptors to inhibit the Hippo pathway kinases Lats1/2, thereby activating YAP and TAZ transcription coactivators, which are oncoproteins repressed by Lats1/2...
  5. Takahashi Y, Miyoshi Y, Takahata C, Irahara N, Taguchi T, Tamaki Y, et al. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res. 2005;11:1380-5 pubmed
    b>LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the promoter regions of these genes as well as its correlation with their mRNA levels were studied in human breast cancers...
  6. Yang X, Yu K, Hao Y, Li D, Stewart R, Insogna K, et al. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol. 2004;6:609-17 pubmed
    ..Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during ..
  7. Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, et al. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene. 2004;23:5266-74 pubmed
    ..A human homologue of the Drosophila warts tumor suppressor, WARTS, is an evolutionarily conserved serine-threonine kinase and implicated in development of ..
  8. Tao W, Zhang S, Turenchalk G, Stewart R, St John M, Chen W, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet. 1999;21:177-81 pubmed
    ..Here, we have isolated mammalian homologues of Drosophila lats. Human LATS1 suppresses tumour growth and rescues all developmental defects, including embryonic lethality in flies...
  9. Yabuta N, Mukai S, Okada N, Aylon Y, Nojima H. The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011;10:2724-36 pubmed
    ..The tumor suppressors Lats1 and Lats2 are serine/threonine kinases that localize to the centrosome and regulate cell cycle progression and ..
  10. Hao Y, Chun A, Cheung K, Rashidi B, Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem. 2008;283:5496-509 pubmed
    ..In this study, we have provided convincing evidence that the LATS1 tumor suppressor can bind to and phosphorylate transcription regulator and oncogene YAP in vitro and in vivo...
  11. Kuninaka S, Nomura M, Hirota T, Iida S, Hara T, Honda S, et al. The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. Oncogene. 2005;24:5287-98 pubmed
    Drosophila tumor suppressor WARTS (Wts) is an evolutionally conserved serine / threonine kinase and participates in a signaling complex that regulates both proliferation and apoptosis to ensure the proper size and shape of the fly...
  12. Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, et al. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol. 2000;149:1073-86 pubmed
    ..A human homologue of the Drosophila warts tumor suppressor, h-warts/LATS1, is an evolutionarily conserved serine/threonine kinase and a dynamic component of the mitotic apparatus...
  13. Xiao L, Chen Y, Ji M, Dong J. KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases. J Biol Chem. 2011;286:7788-96 pubmed publisher
    ..Thus, our study revealed a new connection between KIBRA and mammalian Hippo signaling. ..
  14. Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, et al. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol. 2012;197:625-41 pubmed publisher
    ..In contrast, no phosphatase substrates of LATS1/WARTS kinase, the mammalian equivalent of Dbf2, has been reported...
  15. Yu T, Bachman J, Lai Z. Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer. Genetics. 2013;195:1193-6 pubmed publisher
    The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity...
  16. Visser S, Yang X. Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray. Gene. 2010;449:22-9 pubmed publisher
    Human LATS1 and LATS2) (LATS1/2) are tumor suppressors that have been shown to be mutated or downregulated in several human cancers including leukemia, lung, prostate and breast cancers...
  17. Wennmann D, Schmitz J, Wehr M, Krahn M, Koschmal N, Gromnitza S, et al. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Mol Biol Evol. 2014;31:1710-23 pubmed publisher
    ..Furthermore, all WWC proteins negatively regulate cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP, the major effector of the Hippo pathway...
  18. Habbig S, Bartram M, Müller R, Schwarz R, Andriopoulos N, Chen S, et al. NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol. 2011;193:633-42 pubmed publisher
    ..NPHP4 directly interacted with the kinase Lats1 and inhibited Lats1-mediated phosphorylation of the Yes-associated protein (YAP) and TAZ (transcriptional ..
  19. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154:1342-55 pubmed publisher
    ..Instead, Merlin directly binds and recruits the effector kinase Wts/Lats to the plasma membrane...
  20. Balic A, Bukvić Mokos Z, Marinovic B, Ledić Drvar D. Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete?. Acta Dermatovenerol Croat. 2018;26:68-70 pubmed
    ..Physicians commonly misdiagnose it as tinea pedis or plantar warts. Treatment is quite simple and straightforward, with an excellent expected outcome if treated properly...
  21. Oantă A, Irimie M. Tinea on a Tattoo. Acta Dermatovenerol Croat. 2016;24:223-4 pubmed
    ..leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19)...
  22. Kasuya A, Ohta I, Tokura Y. Structural and immunological effects of skin cryoablation in a mouse model. PLoS ONE. 2015;10:e0123906 pubmed publisher
    ..in several organs, and skin diseases are typical targets as this cryotherapy has been widely used for viral warts, benign tumors, and actinic keratosis...
  23. Badavanis G, Pasmatzi E, Monastirli A, Georgiou S, Tsambaos D. Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children. Acta Dermatovenerol Croat. 2017;25:164-166 pubmed
    ..Originally approved for the treatment of external genital and perianal warts in adults, imiquimod was later approved for the therapy of basal cell carcinomas and actinic keratoses and has ..
  24. Csak T, Bala S, Lippai D, Kodys K, Catalano D, Iracheta Vellve A, et al. MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS ONE. 2015;10:e0129251 pubmed publisher
    ..caspase-3) and reduction in collagen and α smooth muscle actin (αSMA) levels in miR-155 KO mice compared to WTs on MCD diet...
  25. Mullegger R, Häring N, Glatz M. Skin infections in pregnancy. Clin Dermatol. 2016;34:368-77 pubmed publisher
    ..and varicella-zoster virus immunoglobulin for varicella-zoster virus infections, surgical modalities for genital warts, topical clotrimazole and oral fluconazole for Candida vulvovaginitis, amoxicillin and cefuroxime for Lyme ..
  26. Franco Salla G, Prates J, Cardin L, Dos Santos A, Silva W, da Cunha B, et al. Euphorbia tirucalli modulates gene expression in larynx squamous cell carcinoma. BMC Complement Altern Med. 2016;16:136 pubmed publisher
    ..tirucalli), used in the treatment of asthma, ulcers, warts has active components with activities scientifically proven as antimutagenic, anti-inflammatory and anticancer...
  27. Tucktuck M, Ghandour R, Abu Rmeileh N. Waterpipe and cigarette tobacco smoking among Palestinian university students: a cross-sectional study. BMC Public Health. 2017;18:1 pubmed publisher
    During the last two decades, waterpipe tobacco smoking (WTS), also known as hookah, witnessed a global increase in use, especially among youth. Little information is known about the burden of WTS among Palestinian youth...
  28. Marcellusi A. Impact of HPV vaccination: health gains in the Italian female population. Popul Health Metr. 2017;15:36 pubmed publisher
    ..The Markov process considered nine health states (health, anogenital warts, grade 1 and grade 2/3 cervical intraepithelial neoplasia, cervical cancer, anal cancer, death due to cervical ..
  29. AktaÅŸ H, Ergin C, Demir B, Ekiz Ã. Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts. J Cutan Med Surg. 2016;20:118-22 pubmed publisher
    Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy...
  30. Alzoubi K, Egler J, Briglia M, Fazio A, Faggio C, Lang F. Induction of Suicidal Erythrocyte Death by Cantharidin. Toxins (Basel). 2015;7:2822-34 pubmed publisher
    The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy...
  31. Wojtera M, Paradis J, Husein M, Nichols A, Barrett J, Salvadori M, et al. The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature. J Otolaryngol Head Neck Surg. 2018;47:8 pubmed publisher
    ..Inclusion criteria included articles which evaluated the prevalence of HPV in a pediatric cohort without known warts or recurrent respiratory papillomatosis, those which used tonsil biopsy specimens for analysis, and those with six ..
  32. Zhang W, Ji X, Liu Y, Li W, Yang G. Gelidocalamus xunwuensis (Poaceae, Bambusoideae), a new species from southeastern Jiangxi, China. PhytoKeys. 2017;:59-67 pubmed publisher
    ..stellatus in the habit, but differs by internodes sparsely hairy with granuliferous warts, culm sheath stiffly hairy, culm sheath blade broadly lanceolate to narrowly triangular, each node with a ring of ..
  33. Chen K, He J, Wang D, Cao J, Li M, Zhao X, et al. Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma. Int J Oncol. 2014;45:2511-21 pubmed publisher
    Large tumor suppressor 1 (LATS1) gene is one of the key factors in Hippo signaling pathway...
  34. Saito A, Nagase T. Hippo and TGF-β interplay in the lung field. Am J Physiol Lung Cell Mol Physiol. 2015;309:L756-67 pubmed publisher
    ..cascade that involves mammalian Ste20-like serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads to inactivation of transcriptional coactivator with PDZ-binding motif (TAZ) and yes-associated ..
  35. Yuan Z, Wu Y, Zhou J, Che J. A new species of the genus <i>Paramesotriton</i> (Caudata: Salamandridae) from Fujian, southeastern China. Zootaxa. 2016;4205:zootaxa.4205.6.3 pubmed publisher
    ..readily differentiated from its congeners by having: a very rough skin; a continuous, orange, vertebral ridge; few warts on each side of the vertebral ridge; numerous small irregular orange-red or yellow spots on the chin, venter, ..
  36. Hergovich A. Hippo Signaling in Mitosis: An Updated View in Light of the MEN Pathway. Methods Mol Biol. 2017;1505:265-277 pubmed
    ..pathway are conserved from yeast to man, with the yeast analogs of mammalian MST1/2 (fly Hippo), MOB1 (fly Mats), LATS1/2 (fly Warts), and NDR1/2 (fly Tricornered) functioning as essential components of the mitotic exit network (MEN)...
  37. Chen G, Luo H, Yang H, Zhang T, Li S. Water effects on the deformation and fracture behaviors of the multi-scaled cellular fibrous bamboo. Acta Biomater. 2017;: pubmed publisher
    ..mechanisms within the multi-scaled structures were microfiber bridging, multi-walled fiber pull-out, micro warts buckling and crack deflection...
  38. Matsusue E, Fujihara Y, Matsuda E, Tokuyasu Y, Nakamoto S, Nakamura K, et al. Differentiating parotid tumors by quantitative signal intensity evaluation on MR imaging. Clin Imaging. 2017;46:37-43 pubmed publisher
    ..the signal intensity of the enhancing components of tumors, including pleomorphic adenomas (PAs), Warthin tumors (WTs) and malignant tumors (MTs), on various MR sequences and to assess the usefulness of quantitative evaluations for ..
  39. Pantaleo M, Urbini M, Indio V, Ravegnini G, Nannini M, De Luca M, et al. Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST. Mol Cancer Res. 2017;15:553-562 pubmed publisher
    ..NF1 alterations were identified directly by WES. Gene expression from whole transcriptome sequencing (WTS) and miRNA profiling were performed using fresh-frozen, quadruple WT GIST tissue specimens and compared with SDH ..
  40. He X, Xu P, He X, Bian F, Ding P, Yang L, et al. Efficacy of topical administration of Radix Euphorbiae Ebracteolatae on multiple plantar warts: A parallel randomized trial. Chin J Integr Med. 2017;: pubmed publisher
    To investigate the clinical efficacy of Radix Euphorbiae Ebracteolatae in treating multiple plantar warts. Twenty-eight patients with multiple plantar warts on both left and right feet were recruited...
  41. Hamadeh R, Ansari A, Jahrami H, Offi A. Cigarette and waterpipe smoking among adult patients with severe and persistent mental illness in Bahrain: a comparison with the National Non-communicable Diseases Risk Factors Survey. BMC Res Notes. 2016;9:77 pubmed publisher
    ..The study objective was to ascertain whether waterpipe tobacco smoking (WTS), cigarette smoking and all types of tobacco smoking are more common among Bahraini patients with severe and ..
  42. Yee C, Massaad M, Bainter W, Ohsumi T, Föger N, Chan A, et al. Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. J Allergy Clin Immunol. 2016;137:879-88.e2 pubmed publisher
    ..of the primary immunodeficiency in 2 young adult siblings with a history of disseminated varicella, cutaneous warts, and CD4(+) T-cell lymphopenia...
  43. Chagtai T, Zill C, Dainese L, Wegert J, Savola S, Popov S, et al. Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study. J Clin Oncol. 2016;34:3195-203 pubmed publisher
    ..One hundred sixty-seven (28%) of 586 WTs had 1q gain. Five-year event-free survival (EFS) was 75.0% in patients with 1q gain (95% CI, 68.5% to 82.0%) and 88...
  44. Righolt C, Pabla G, Mahmud S. The Direct Medical Costs of Diseases Associated with Human Papillomavirus Infection in Manitoba, Canada. Appl Health Econ Health Policy. 2018;16:195-205 pubmed publisher
    ..We found that the median cost of treating a case of anogenital warts was $130...
  45. Jalali L, Nezhad Ahmadi M, Gohari M, Bigelow P, McColl S. The impact of psychological factors on self-reported sleep disturbance among people living in the vicinity of wind turbines. Environ Res. 2016;148:401-410 pubmed publisher
    ..development has made Canada the fifth-largest market in the world for the installation of new wind turbines (WTs)...
  46. Rybarczyk A, Klacz J, Wronska A, Matuszewski M, Kmiec Z, Wierzbicki P. Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome. Oncol Rep. 2017;38:427-439 pubmed publisher
    ..Hippo signaling, with its key kinases, MST2 and large tumor suppressor kinase 1 (LATS1), plays a significant role in the negative regulation of the amount and activity of YAP1 protein...
  47. Brotherton J, Giuliano A, Markowitz L, Dunne E, Ogilvie G. Monitoring the impact of HPV vaccine in males-Considerations and challenges. Papillomavirus Res. 2016;2:106-111 pubmed publisher
    ..population level HPV infection control and to directly prevent HPV-related disease in males such as anogenital warts and anal cancers. Coverage and adverse events surveillance are essential components of post-vaccination monitoring...
  48. Kim Y, Ohta T, Oh J, Le Calvez Kelm F, McKay J, Voegele C, et al. TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors. Am J Pathol. 2014;184:2374-81 pubmed publisher
    ..peripheral schwannomas also carried the MSH4 germline mutation, and in addition, a germline mutation of the LATS1 gene (c.286C>T; p.R96W)...
  49. Zhou Y, Tao F, Cheng Y, Xu F, Yao F, Feng D, et al. Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma. Clin Invest Med. 2014;37:E384-94 pubmed
    ..We explored the abnormal expression of ITCH (AIP4) and its degrading substrate Large Tumor Suppressor 1 (LATS1) in CINs and cervical cancers, which might disrupt the normal differentiation of the cervical epithelia and ..
  50. Chung H, Augustine G, Choi K. Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling. Dev Cell. 2016;36:511-24 pubmed publisher
    ..In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki)...
  51. Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher
    ..that, in three different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits tumor growth...
  52. Brager A, Heemstra L, Bhambra R, Ehlen J, Esser K, Paul K, et al. Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock. Biochimie. 2017;132:161-165 pubmed publisher
    ..RER was lower for muscle overexpressed females compared to female WTs. There were no genotype-dependent differences in metabolic phenotypes for males...
  53. Peng C, Zhu Y, Zhang W, Liao Q, Chen Y, Zhao X, et al. Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation. Mol Cell. 2017;68:591-604.e5 pubmed publisher
    ..YAP O-GlcNAcylation disrupts its interaction with upstream kinase LATS1, prevents its phosphorylation, and activates its transcriptional activity...
  54. Zimmermann M, Kohut T, Fisher W. HPV Unvaccinated Status and HPV Sexual Risk Behaviour are Common among Canadian Young Adult Women and Men. J Obstet Gynaecol Can. 2018;40:410-417 pubmed publisher
    ..determined that in the female unvaccinated population, the proportion at significantly increased risk for genital warts, cervical, anal, and oropharyngeal cancer was 11.0%, 30.0%, 6.5%, and 49.2% respectively...
  55. Sekido Y. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Cancers (Basel). 2018;10: pubmed publisher
    ..MMs also exhibit inactivation of Hippo pathway components including LATS1/2, strongly suggesting that merlin-Hippo pathway dysregulation plays a key role in the development and progression ..
  56. Shapiro G, Perez S, Naz A, Tatar O, Guichon J, Amsel R, et al. Investigating Canadian parents' HPV vaccine knowledge, attitudes and behaviour: a study protocol for a longitudinal national online survey. BMJ Open. 2017;7:e017814 pubmed publisher
    Human papillomavirus (HPV), a sexually transmitted infection, can cause anogenital warts and a number of cancers...
  57. Wieland U, Kreuter A. [Genital warts in HIV-infected individuals]. Hautarzt. 2017;68:192-198 pubmed publisher
    Anogenital warts (condylomata acuminata) are much more frequent in human immunodeficiency (HIV)-positive patients compared to HIV-negative individuals...
  58. Baroni A, De Filippis A, Oliviero G, Fusco A, Perfetto B, Buommino E, et al. Effect of 1064-nm Q-switched Nd:YAG laser on invasiveness and innate immune response in keratinocytes infected with Candida albicans. Lasers Med Sci. 2018;33:941-948 pubmed publisher
    ..It is used to treat onychomycoses, warts, and wounds and in some other treatments...
  59. Tian C, Hromatka B, Kiefer A, Eriksson N, Noble S, Tung J, et al. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun. 2017;8:599 pubmed publisher
    ..procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast ..
  60. Zhang Y, Wang D, Zhang M, Wei H, Lu Y, Sun Y, et al. Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells. Exp Cell Res. 2018;362:43-50 pubmed publisher
    ..Furthermore, our studies show that PRMT1 silencing promotes the phosphorylation of LATS1, and then induces YAP phosphorylation, while overexpression of PRMT1 down-regulates the phosphorylation of LATS1 ..
  61. Clavero O, McCloskey J, Molina V, Quirós B, Bravo I, de Sanjosé S, et al. Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping. Papillomavirus Res. 2017;3:11-17 pubmed publisher
    ..We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients...
  62. Si Y, Ji X, Cao X, Dai X, Xu L, Zhao H, et al. Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1. Cancer Res. 2017;77:4868-4880 pubmed publisher
    ..Here, we report tyrosine phosphorylation of the Hippo pathway tumor suppressor LATS1 as a mechanism underlying its regulation by cell adhesion...
  63. Alam M, Bouillez A, Tagde A, Ahmad R, Rajabi H, Maeda T, et al. MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway. Mol Cancer Res. 2016;14:1266-1276 pubmed
    ..Notably, CRB3 activates the core kinase cassette of the Hippo pathway, which includes LATS1 and LATS2...
  64. Plouffe S, Meng Z, Lin K, Lin B, Hong A, Chun J, et al. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016;64:993-1008 pubmed publisher
    ..By this approach, we provide an overview of the functional importance of many Hippo pathway components and demonstrate NF2 and RHOA as important regulators of YAP/TAZ and TAOK1/3 as direct kinases for LATS1/2.
  65. Thompson E, Best A, Vamos C, Daley E. "My mom said it wasn't important": A case for catch-up human papillomavirus vaccination among young adult women in the United States. Prev Med. 2017;105:1-4 pubmed publisher
    The human papillomavirus (HPV) vaccine prevents HPV-related diseases, including anogenital cancers and genital warts. In the United States, while it is recommended to adolescents ages 11 to 12, catch-up vaccination is available for those ..
  66. Gomes C, Ruiz J. Carrion's Disease: the Sound of Silence. Clin Microbiol Rev. 2018;31: pubmed publisher
    ..Following infection there is the chronic phase, Peruvian warts, involving abnormal proliferation of the endothelial cells...
  67. Thöne K, Horn J, Mikolajczyk R. Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine-an interrupted time series analysis from 2005 to 2010 using health insurance data. BMC Infect Dis. 2017;17:564 pubmed publisher
    ..of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital warts (AGWs) were observed, but it was not clear at what level the incidence would stabilize and to what extent herd ..
  68. Maver P, Poljak M. Progress in prophylactic human papillomavirus (HPV) vaccination in 2016: A literature review. Vaccine. 2018;36:5416-5423 pubmed publisher
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    ..achieved 20% coverage per year, without a boys program, will prevent 49,283 (31,253-71,500) cases of anogenital warts, 191 (88-319) person-years living with anal cancer through 2017-2036 but will only stablise anal cancer incidence...
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    Cutaneous human papillomavirus (HPV) types 1, 2, 4, 7 and 57 are reportedly found in cutaneous warts. However, there are few reports that have investigated the prevalence of mucosal HPV types in cutaneous warts...
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    ..Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1//2 as negative growth regulators and ..
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    ..These include Akt phosphorylation of MST2 and a feedback phosphorylation of Raf-1 Ser 259 by LATS1, which enables Raf-1 to suppress both MST2 and MEK signalling...
  90. Zhang Y, Wang T, Wang S, Xiong Y, Zhang R, Zhang X, et al. Nkx2-2as Suppression Contributes to the Pathogenesis of Sonic Hedgehog Medulloblastoma. Cancer Res. 2018;78:962-973 pubmed publisher
    ..against miR-103 and miR-107, sequestering them and thereby derepressing their tumor suppressive targets BTG2 and LATS1 and impeding cell division and migration...
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    To investigate large tumor suppressor 1 (LATS1) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC)...