LAT2

Summary

Gene Symbol: LAT2
Description: linker for activation of T cells family, member 2
Alias: LAB, NTAL, WBSCR15, WBSCR5, WSCR5, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, linker for activation of B-cells, linker for activation of T cells, transmembrane adaptor 2, linker for activation of T-cells family member 2, membrane-associated adapter molecule, non-T-cell activation linker
Species: human

Top Publications

  1. ncbi Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23
    D W Martindale
    Department of Biology, Centre for Environmental Health, P O Box 3020, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
    Mamm Genome 11:890-8. 2000
  2. ncbi Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
    L R Osborne
    Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 36:328-36. 1996
  3. ncbi Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid
    T Jindo
    Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 29:607-16. 2001
  4. ncbi Effects of corn oil, time-related changes, and inter-laboratory variability on tumor occurrence in control Fischer 344 (F344/N) rats
    J K Haseman
    Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicol Pathol 20:52-60. 1992
  5. ncbi [Rapid detection of Escherichia coli 0157:H7 in feces by latex agglutination and immunochromatographic assay]
    M Komatsu
    Department of Clinical Pathology, Tenri Hospital
    Kansenshogaku Zasshi 71:1124-30. 1997
  6. ncbi Sleep in the laboratory and sleep at home II: comparisons of middle-aged insomnia sufferers and normal sleepers
    J D Edinger
    VA and Duke University Medical Centers, Durham, NC 27705, USA
    Sleep 24:761-70. 2001
  7. ncbi Intra-articular fractures of the distal end of the radius treated with an adjustable fixator system
    R M Zanotti
    Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor 48109 0328, USA
    J Hand Surg Am 22:428-40. 1997
  8. ncbi Evaluation of EEG cyclic alternating pattern during sleep in insomniacs and controls under placebo and acute treatment with zolpidem
    M G Terzano
    Department of Neurology, University of Parma, Italy
    Sleep 15:64-70. 1992
  9. ncbi Nightcap: a home-based sleep monitoring system
    A Mamelak
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 12:157-66. 1989
  10. ncbi Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 278:43838-45. 2003

Research Grants

  1. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
  2. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2003
  3. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2007
  4. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2006
  5. Acetylcysteine: An Antidote for Methylmercury Poisoning
    TRACEY SIMMONS WILLIS; Fiscal Year: 2003
  6. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar Bulun; Fiscal Year: 2007
  7. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
  8. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2007
  9. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
  10. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. ncbi Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23
    D W Martindale
    Department of Biology, Centre for Environmental Health, P O Box 3020, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
    Mamm Genome 11:890-8. 2000
    ..Evidence was also found for WBSCR5 in this region, but not the previously proposed genes WSCR2 and WSCR6...
  2. ncbi Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
    L R Osborne
    Department of Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 36:328-36. 1996
    ..LIMK1 and WSCR1 may be particularly relevant when explaining cognitive defects observed in WS patients...
  3. ncbi Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid
    T Jindo
    Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 29:607-16. 2001
    ..Preliminary data from this lab suggested the involvement of protein kinase activity in the development of this lesion, a hypothesis explored in ..
  4. ncbi Effects of corn oil, time-related changes, and inter-laboratory variability on tumor occurrence in control Fischer 344 (F344/N) rats
    J K Haseman
    Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicol Pathol 20:52-60. 1992
    ..control data are to be utilized in the interpretation of experimental results, primary emphasis should be given to lab and route of administration-specific tumor rates for studies that are contemporary to the study under evaluation...
  5. ncbi [Rapid detection of Escherichia coli 0157:H7 in feces by latex agglutination and immunochromatographic assay]
    M Komatsu
    Department of Clinical Pathology, Tenri Hospital
    Kansenshogaku Zasshi 71:1124-30. 1997
    The rapid detection method of Escherichia coli O157 in feces by using the latex agglutination test kit (Prolex; Pro Lab Diagnostics) and the immunochromatic assay kit (NOW EH. E. coli; Binax) was studied...
  6. ncbi Sleep in the laboratory and sleep at home II: comparisons of middle-aged insomnia sufferers and normal sleepers
    J D Edinger
    VA and Duke University Medical Centers, Durham, NC 27705, USA
    Sleep 24:761-70. 2001
    ..compared adaptation responses and sleep pattern differences shown by normal sleepers and insomnia sufferers during lab (LPSG) and home (HPSG) polysomnography. DESIGN: A counter-balanced, matched-group design was used...
  7. ncbi Intra-articular fractures of the distal end of the radius treated with an adjustable fixator system
    R M Zanotti
    Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor 48109 0328, USA
    J Hand Surg Am 22:428-40. 1997
    ..in 16 adults (mean age, 34 years) were treated with the Wrist Jack external fixator system (Hand Biomechanics Lab, Sacramento, CA) and evaluated at a mean follow-up period of 25 months...
  8. ncbi Evaluation of EEG cyclic alternating pattern during sleep in insomniacs and controls under placebo and acute treatment with zolpidem
    M G Terzano
    Department of Neurology, University of Parma, Italy
    Sleep 15:64-70. 1992
    ..After adaptation to the sleep lab, 18 subjects (12 with persistent psychophysiological insomnia and 6 without sleep complaints), all aged 40-60 years,..
  9. ncbi Nightcap: a home-based sleep monitoring system
    A Mamelak
    Laboratory of Neurophysiology, Harvard Medical School, Boston, Massachusetts 02115
    Sleep 12:157-66. 1989
    ..Four subjects were monitored in the sleep lab with both our headgear and standard polysomnography...
  10. ncbi Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 278:43838-45. 2003
    ..Distinct from already known system L transporters LAT1 and LAT2, which form heterodimeric complex with 4F2 heavy chain, LAT3 was functional by itself in Xenopus oocytes...
  11. ncbi [Little known activity of the Czestochowa typhus Institute in 1943 and 1944]
    P Aramowicz
    Katedra Historii Medycyny i Farmacji, Wierzbowa
    Arch Hist Filoz Med 59:85-90. 1996
    ..plant employed there being no data left but according to employees still alive there must have been about a hundred lab. staff and two hundred feeders. The plant was divided into "breeding", "preparatory" and "liofilisation" sections...
  12. ncbi Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids
    Y Fukasawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:9690-8. 2000
    ..homology (66% identity at the amino acid level) to the Na(+)-independent broad scope neutral amino acid transporter LAT2 (Segawa, H., Fukasawa, Y., Miyamoto, K., Takeda, E., Endou, H., and Kanai, Y. (1999) J. Biol. Chem...
  13. ncbi The rape exam: beyond the hospital emergency room
    P Y Martin
    Florida State University School of Social Work, Tallahassee 32306
    Women Health 12:5-28. 1987
    ..2), a nonhospital-based SATC, a proprietary OB/GYN clinic, a medical examiner's office, and a law enforcement crime lab. Open-ended interviews indicate that major problems with hospitals as exam sites stem from physicians' dislike of ..
  14. ncbi Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells
    Shiho Kaneko
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan
    Invest Ophthalmol Vis Sci 48:464-71. 2007
    ..This study was intended to clarify the mechanism of ornithine cytotoxicity and to determine the responsible amino acid transporters...
  15. ncbi Sleep in the laboratory and sleep at home: comparisons of older insomniacs and normal sleepers
    J D Edinger
    Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Sleep 20:1119-26. 1997
    ..e. lab and home)...
  16. ncbi Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells
    Do Kyung Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Mitaka, Japan
    Biochim Biophys Acta 1565:112-21. 2002
    ..membrane together with its associating protein 4F2hc, whereas T24 cells do not express the other system L isoform LAT2. The uptake of [14C]L-leucine by T24 cells is Na(+)-independent and almost completely inhibited by system L ..
  17. ncbi Full polysomnography in the home
    J M Fry
    Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pa. 19129, USA
    Sleep 21:635-42. 1998
    ..However, patients reported more sleep time and a better overall test experience in the lab. Assessments of sleep quality and morning alertness compared to usual were rated higher in the lab...
  18. ncbi Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells
    Sheng Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Cell Physiol 292:C1263-71. 2007
    ..that uptake increased only when both 4F2 heavy chain (4F2HC) and either L-type amino acid transporter 1 (LAT1) or LAT2 light chain were coexpressed...
  19. ncbi [Diagnostic focus on the child with epilepsy and neuropsychological deterioration]
    A C Rodríguez-Barrionuevo
    Hospital Materno Infantil, Unidad de Neuropediatria, Carlos Haya, Malaga, Espana
    Rev Neurol 26:322-30. 1998
    ..the diagnosis of the hereditary metabolic and heredodegeneratives diseases can be made by the characteristics of the seizures but in most cases the diagnosis will be established by the symptoms of the basic disease and the lab data.
  20. ncbi Assessment of accuracy and analysis time of a novel device to monitor sleep and breathing in the home
    D P White
    National Jewish Center, Denver V.A. Medical Center, CO 80220, USA
    Sleep 18:115-26. 1995
    ..Two separate studies were completed. NW was compared to a simultaneously obtained PSG in 30 patients (IN-LAB study)...
  21. doi Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells)
    Atsushi Yamamoto
    Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Sci 99:2475-82. 2010
    System L, which is encoded by LAT1 and LAT2, is an amino acid transport system that transports neutral amino acids, including several essential amino acids in an Na+-independent manner...
  22. ncbi Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols
    Sheng Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:20102-10. 2005
    ..To show that system L family members mediate uptake, we expressed two members, LAT1 and LAT2, in Xenopus oocytes...
  23. ncbi A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2
    D B Shennan
    Hannah Research Institute, Ayr Scotland, UK
    Biochim Biophys Acta 1564:133-9. 2002
    ..Lactating rat mammary tissue was found to express both LAT1 and LAT2 mRNA...
  24. ncbi Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway
    Tamara Ramadan
    Institute of Physiology and Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse, Zurich, Switzerland
    J Cell Physiol 206:771-9. 2006
    ..The best characterized basolateral amino acid transporters are y+LAT1-4F2hc and LAT2-4F2hc that function as obligatory exchangers and thus, do not contribute to net amino acid (re)absorption...
  25. ncbi High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells
    Patricio Soares-da-Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
    Am J Physiol Renal Physiol 287:F252-61. 2004
    ..05) by L-cysteine, L-leucine, BCH, and L-DOPA but not by L-arginine. RT-PCR detected LAT1 and LAT2 transcripts in LLC-PK1 cells...
  26. ncbi Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells
    Patricio Soares-da-Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal
    FASEB J 18:1489-98. 2004
    Organ-specific overexpression of type 2 L-amino acid transporter (LAT2) in the kidney of the spontaneous hypertensive rat (SHR), accompanied by an enhanced ability to take up L-DOPA, may constitute the basis for the enhanced renal ..
  27. ncbi System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
    Do Kyung Kim
    Department of Oral Physiology, Chosun University College of Dentistry, 375 Seosuk dong, Dong Gu, Gwangju, 501 759, South Korea
    Neurosci Res 50:437-46. 2004
    ..The rat astrocyte cultures expressed the l-type amino acid transporter 2 (LAT2) with its subunit 4F2hc, whereas the l-type amino acid transporter 1 (LAT1) was not expressed in these cells...
  28. ncbi [Randomized, comparative study on the treatment of moderate arterial hypertension during pregnancy: methyldopa, acebutolol, labetalol]
    H Lardoux
    Service de cardiologie, , Corbeil-Essonnes
    Arch Mal Coeur Vaiss 81:137-40. 1988
    ..antihypertensive sequence was to compare a betablocker with sympathomimetic activity (ACE) and an alphabetablocker (LAB) to the gold standard treatment (MD) in moderate HDP (BP greater than 90 mmHg)...
  29. doi Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+ LAT2 in rat cerebral cortex: implications for the nitric oxide/cGMP pathway
    Magdalena Zielinska
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5 Str, 02 106 Warsaw, Poland
    Neurochem Int 58:190-5. 2011
    ..study we demonstrate that a 3-day HA in the ammonium acetate model increases the expression in the brain of y(+)LAT2, the heteromeric transporter which preferentially stimulates Arg efflux from the cells in exchange for Gln...
  30. ncbi Alanine metabolism, transport, and cycling in the brain
    Stefan Broer
    School of Biochemistry and Molecular Biology, Australian National University, Acton, Canberra ACT, Australia
    J Neurochem 102:1758-70. 2007
    ..Alanine uptake into astrocytes was largely mediated by system L isoform LAT2, whereas alanine uptake into neurons was mediated by Na(+)-dependent transporters with properties similar to system ..
  31. ncbi L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter
    D B Shennan
    Hannah Research Institute, Ayr, Scotland, KA6 5HL, UK
    Biochim Biophys Acta 1664:206-16. 2004
    ..Quantitative real-time PCR revealed that LAT1 mRNA was approximately 200 times more abundant than LAT2 mRNA in MCF-7 cells and confirmed that MDA-MB-231 cells express LAT1 but not LAT2 mRNA...
  32. ncbi Nocturnal cluster headache associated with sleep apnea. A case report
    P Buckle
    Section of Respiratory Diseases, University of Manitoba, Winnipeg, Canada
    Sleep 16:487-9. 1993
    ..Following investigation in the sleep lab he was found to have obstructive sleep apnea (OSA) with associated oxygen desaturations during rapid eye movement (..
  33. doi Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis
    Wojciech Hilgier
    Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurobiol Dis 35:75-81. 2009
    ..The L-arginine co-substrates of y(+)LAT2 transport system, L-leucine and cyclo-leucine, mimicked the effect of exogenous Gln, suggesting that Gln limits Arg ..
  34. ncbi The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex
    HENRY QUINONES
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 287:F74-80. 2004
    ..yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2)...
  35. ncbi Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger
    Tamara Ramadan
    Zurich Centre for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Pflugers Arch 454:507-16. 2007
    ..Because LAT2-4F2hc (Slc7a8-Slc3a2), the best known basolateral neutral amino acid transporter of these epithelial cells, ..
  36. ncbi Dietary protein quality and feed restriction influence abundance of nutrient transporter mRNA in the small intestine of broiler chicks
    Elizabeth R Gilbert
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 138:262-71. 2008
    ..amino acid transporter 3 (EAAT3), Na+-independent cationic and Na+-dependent neutral amino acid transporter (y+ LAT2), and Na+-independent cationic amino acid transporter 2 (CAT2)], glucose transporter [Na+-dependent glucose and ..
  37. ncbi Functional and molecular characteristics of system L in human breast cancer cells
    D B Shennan
    Hannah Research Institute, Ayr, Scotland KA6 5HL, UK
    Biochim Biophys Acta 1611:81-90. 2003
    ..MDA-MB-231 and MCF-7 cells expressed LAT1 and CD98 mRNA. MCF-7 cells also expressed LAT2 mRNA...
  38. doi Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1β: implications for hypoxic neuronal injury
    Nicole A Jackman
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    Glia 58:1806-15. 2010
    ..IL-1β does not regulate the light chain of the amino acid transporter, LAT2, or the expression and function of astrocytic excitatory amino acid transporters (EAATs), demonstrating some target ..
  39. ncbi Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
    Sun Young Park
    Department of Pediatrics, Kwangju Christian Hospital, Gwangju 503 715, Korea
    Arch Pharm Res 28:421-32. 2005
    ..Therefore, LAT2 and TAT1 play essential roles in the reabsorption of neutral amino acids from the epithelial cells to the blood ..
  40. ncbi [Actigraphy: methodological limits for evaluation of sleep stages and sleep structure of healthy probands]
    R Conradt
    Schlafmedizinisches Labor der Medizinischen Poliklinik,
    Pneumologie 51:721-4. 1997
    ..6 +/- 3.3 kg/m2 participated in the study. All subjects were recorded in the sleep lab via cardiorespiratory polysomnography and wrist actigraphy (Ambulatory Monitoring, Ardsley, USA) worn on the non-..
  41. doi Vacuolin-1-modulated exocytosis and cell resealing in mast cells
    Gouse M Shaik
    Laboratory of Signal Transduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cell Signal 21:1337-45. 2009
    ..Furthermore, our results support the concept that lysosomal exocytosis is involved in the repair of injured plasma membranes...
  42. pmc Expression of heteromeric amino acid transporters along the murine intestine
    Mital H Dave
    Institute of Physiology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    J Physiol 558:597-610. 2004
    ..Immunohistochemistry demonstrated basolateral coexpression of 4F2hc, LAT2 and y(+)-LAT1 in stomach and small intestine, whereas rBAT and b degrees (,+)AT were found colocalizing on the ..
  43. ncbi Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters
    Emiko Morimoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
    J Pharmacol Sci 108:505-16. 2008
    ..Previously, we identified two isoforms of transporters: L-type amino acid transporter 1 (LAT1) and 2 (LAT2) and revealed their distinct substrate selectivity and transport properties...
  44. ncbi CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
    ..L. (2001) J. Biol. Chem. 276, 39282-39289). In the present study we examined the interaction of CD98/LAT2 with intracellular adhesion molecule I (ICAM-1) and the potential of such interaction on the activation of ..
  45. doi Properties of L-type amino acid transporter 1 in epidermal ovarian cancer
    Masahiko Kaji
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Int J Gynecol Cancer 20:329-36. 2010
    ....
  46. ncbi Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins
    Iain C Macaulay
    Department of Haematology, University of Cambridge, Cambridge, UK
    Blood 109:3260-9. 2007
    ..Many of these transcripts, including G6b, G6f, LRRC32, LAT2, and the G protein-coupled receptor SUCNR1, encode proteins with structural features or functions that suggest they ..
  47. ncbi Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: a study involving the in vivo retinal uptake and vitreal pharmacokinetics of L-phenyl alanine
    Harisha Atluri
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110 2499, USA
    Int J Pharm 347:23-30. 2008
    ..The purpose of this study is to elucidate the functional activity of large neutral amino acid transporter (LAT) in rabbit retina and to delineate its role in the retinal uptake and intravitreal pharmacokinetics of L-phenylalanine (L-Phe)...
  48. pmc Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains
    A Bröer
    Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
    Biochem J 355:725-31. 2001
    ..light chains, C-terminally truncated mutants of 4F2hc were constructed and co-expressed with the light chains LAT1, LAT2 and y(+)LAT2...
  49. ncbi An introduction to computerised speech lab
    K Van Lierde
    Department of Otorhinolaryngology, University Hospital, Ghent, Belgium
    Acta Otorhinolaryngol Belg 50:309-14. 1996
    ..This can be provided by a computerised technique, the computerised speech lab (CLS), which performs an acoustic analysis of the voice samples and gives objective figures of multiple parameters.
  50. ncbi Multiple pathways for cationic amino acid transport in rat thyroid epithelial cell line PC Cl3
    Tiziano Verri
    Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, Italy
    Am J Physiol Cell Physiol 288:C290-303. 2005
    ..Uptake data correlate to expression of the genes encoding for CAT-1, CAT-2B, 4F2hc, y(+)LAT1, y(+)LAT2, rBAT, and b(0,+)AT, an expression profile that is also shown by the rat thyroid gland...
  51. pmc Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties
    Bruno Reynolds
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, U K
    Biochem J 420:363-72. 2009
    ..The heterodimeric complexes of CD98hc and the light chains LAT1 (L-type amino acid transporter 1) or LAT2 specifically promote sodium-independent System L exchange of neutral amino acids, including leucine...
  52. ncbi Fc gamma RII activation induces cell surface ceramide production which participates in the assembly of the receptor signaling complex
    Marek Korzeniowski
    The Nencki Institute of Experimental Biology, Department of Cell Biology, Warsaw, Poland
    Cell Physiol Biochem 20:347-56. 2007
    ..The effects of the drugs on the phosphorylation of Fc gamma RII and NTAL were prominent and correlated with a reduction of the cell surface ceramide production by imipramine and an ..
  53. ncbi [Amino acid transporter molecule as a drug target]
    H Endou
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Yakurigaku Zasshi 114:11P-16P. 1999
    ..As a homolog of LAT1, we also cloned LAT2 which is expressed in various normal tissues...
  54. ncbi Relationship of slow and rapid EEG components of CAP to ASDA arousals in normal sleep
    L Parrino
    , Parma, Italia
    Sleep 24:881-5. 2001
    ..SETTING: 40 sleep-lab accomplished recordings. PARTICIPANTS: Healthy subjects belonging to a wide age range (38 +/- 20 yrs.)...
  55. doi LAT1 regulates growth of uterine leiomyoma smooth muscle cells
    - Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Reprod Sci 17:791-7. 2010
    L-type amino acid transporter 1 (LAT1) and LAT2 were shown to encode system L, which mediates the Na(+)-independent transport of branched-chain and aromatic amino acids...
  56. ncbi [Is SnorEx also ApneaEx? A study with a new intra-oral prosthesis as a form of therapy of obstructive sleep apnea syndrome]
    B Schonhofer
    Krankenhaus Kloster Grafschaft, Zentrum fur Pneumologie und Allergologie, Schmallenberg Grafschaft
    Pneumologie 51:804-8. 1997
    ..We performed the study to test the effectiveness of the device in reducing the number of obstructive events...
  57. doi Renal amino acid transport systems and essential hypertension
    Vanda Pinto
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    FASEB J 27:2927-38. 2013
    ..include the sodium-dependent systems B(0), B(0,+), and y(+)L, and the sodium-independent systems L (LAT1 and LAT2) and b(0,+)...
  58. doi Production of free glutamate in milk requires the leucine transporter LAT1
    Takuya Matsumoto
    Frontier Research Laboratories, Institute for Innovation, Ajinomoto Corporation, Kawasaki ku, Kawasaki shi, Japan and
    Am J Physiol Cell Physiol 305:C623-31. 2013
    ..Gene expression analysis indicated that mammary cells express two Leu transporters, LAT1 and LAT2, with LAT1 being more abundant than LAT2...
  59. doi Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
    Börge Arndt
    Institutes of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Leukoc Biol 93:353-62. 2013
    ..However, more recent in vivo studies have demonstrated that with the exception of LAT, TRAPs, such as SIT, NTAL, and LAX, only minimally affect immune cell functions...
  60. doi Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells
    Mitesh Patel
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA
    Int J Pharm 443:245-53. 2013
    ..RT-PCR analysis provided a product band at 658 and 840 bp, specific to LAT1 and LAT2, respectively...
  61. pmc Maternal transfer of the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) via milk to suckling offspring
    Marie Andersson
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e78133. 2013
    ..with other amino acids and a low sodium dependency of the influx suggests that the amino acid transporters LAT1 and LAT2 are involved in the transport of L-BMAA into milk...
  62. ncbi The involvement of L-type amino acid transporters in theanine transport
    Sachiko Yamamoto
    Department of Chemistry, Kyorin University School of Medicine, Tokyo, Japan
    Biosci Biotechnol Biochem 76:2230-5. 2012
    ..Additionally, in experiments using cells stably expressing two system L isoforms, LAT1 and LAT2, we found that the two isoforms mediated L-theanine transport to similar extents...
  63. ncbi An amino acid transporter involved in gastric acid secretion
    Philipp Kirchhoff
    Institute of Physiology and Center for Integrative Human Physiology CIHP, University of Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    Pflugers Arch 451:738-48. 2006
    ..in mouse stomach parietal cells the expression of the system L heteromeric amino acid transporter comprised of the LAT2-4F2hc dimer...
  64. doi Effect of amino acids supply in reduced crude protein diets on performance, efficiency of mammary uptake, and transporter gene expression in lactating sows
    R Manjarin
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 90:3088-100. 2012
    ..Transcript abundance of AA transporters b(0,+)AT (SLC7A9), y(+)LAT2 (SLC7A6), ATB(0,+) (SLC6A14), CAT-1 (SLC7A1), and CAT-2b (SLC7A2) and milk protein β-casein (CSN2) and LALBA (α-..
  65. pmc Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity
    Carolina H Thomé
    Instituto Nacional de Ciência e Tecnologia em Células Tronco e Terapia Celular, Fundação Hemocentro de Ribeirão Preto, 14051 140, Ribeirao Preto, SP, Brazil
    Mol Cell Proteomics 11:1898-912. 2012
    ..One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B ..
  66. pmc Limnanthes douglasii lysophosphatidic acid acyltransferases: immunological quantification, acyl selectivity and functional replacement of the Escherichia coli plsC gene
    Adrian P Brown
    Department of Biological Sciences, University of Durham, South Road, Durham DH1 3LE, UK
    Biochem J 364:795-805. 2002
    ..lysophosphatidic acid acyltransferase (LPAAT) enzymes from Limnanthes douglasii (meadowfoam), LAT1 and LAT2, using the predicted soluble portion of each protein as recombinant protein antigens...
  67. ncbi Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells
    Christian Bauch
    Institute of Physiology and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Switzerland
    J Biol Chem 278:1316-22. 2003
    The heteromeric amino acid transporters b(0,+)AT-rBAT (apical), y(+)LAT1-4F2hc, and possibly LAT2-4F2hc (basolateral) participate to the (re)absorption of cationic and neutral amino acids in the small intestine and kidney proximal tubule...
  68. ncbi Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells
    Takanori Nemoto
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 263 8522, Chiba, Japan
    Eur J Pharmacol 458:17-24. 2003
    ..System L is composed of the 4F2 light chains (LAT1 or LAT2) and the heavy chain, and the transcripts of these components were detected in RNA from PC12 cells...
  69. ncbi Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry
    Zsolt Boldogkoi
    Laboratory of Neuromorphology, Department of Anatomy, Semmelweis University, Budapest, Hungary
    Brain Res Mol Brain Res 109:105-18. 2002
    ..fluorescent protein) genes into the genomic loci containing the putative latency-associated transcript promoter (P(LAT2)), resulting in the disruption of the promoter function...
  70. ncbi Glutamine efflux from astrocytes is mediated by multiple pathways
    Joachim W Deitmer
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
    J Neurochem 87:127-35. 2003
    ..the expression of glutamine transporter mRNAs in cultured astrocytes it appeared likely that glutamine efflux was mediated by SN1, LAT2, ASCT2 and an additional, yet unidentified, transporter that mediates about 40% of the basal efflux.
  71. ncbi Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells
    J F Dye
    Leukocyte Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ
    FASEB J 18:125-7. 2004
    ..RT-PCR amplification products for eNOS, CAT1, CAT2A, CAT2B, CAT4, 4F2hc (CD98), rBAT and the light chains y+LAT1, y+LAT2, and b0+T1 were detected in HPMEC, but not B0+...
  72. ncbi [Sleep and respiration at an altitude of 6,400 m (Aconcagua, Argentina]
    N Netzer
    Abteilung Pneumologie,
    Pneumologie 51:729-35. 1997
    ..Modifying a portable sleep lab (Vitalog HMS 5000), we were able to conduct 7 channel polygraphy on our ascent to the Aconcagua up to an altitude ..
  73. doi Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
    Cornelia Rieke
    Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Cell Signal 22:395-403. 2010
    ..DRM-associated molecules we identified the transmembrane adapter proteins (TRAPs), non-T cell activation linker (NTAL) and lymphocyte-specific protein tyrosine kinase (Lck)-interacting membrane protein (LIME) to be regulated by H...
  74. doi Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
    Eva K Wirth
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci 29:9439-49. 2009
    ..We then demonstrated Lat2 expression in cultured neurons and throughout murine brain development...
  75. ncbi Enhancement of host resistance against Salmonella typhimurium infection by a diet supplemented with yogurt
    C De Simone
    Clinica Malattie Infettive, , Roma, Italy
    Immunopharmacol Immunotoxicol 10:399-415. 1988
    The effect of a diet supplemented with yogurt containing live lactobacilli (LAB) - Lactobacillus bulgaricus and Streptococcus thermophilus - on the response of inbred mice to infection with Salmonella typhimurium was elaborated...
  76. doi Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles
    Bianca Maria Rotoli
    Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Via Volturno, 39 43125, Parma, Italy
    Pflugers Arch 458:1163-73. 2009
    ..no information exists on the role of the heterodimeric transporters of system y(+)L (4F2hc/y(+)LAT1 and 4F2hc/y(+)LAT2) which operates transmembrane arginine fluxes cis-inhibited by neutral amino acids in the presence of sodium...
  77. pmc Investigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia
    Yumi Imai
    University of California at San Francisco, 94143 0412, USA
    J Virol 83:7873-82. 2009
    ..Studies with the chimeric virus HSV-1 17syn+/LAT2, an HSV-1 virus engineered to express HSV-2 LAT, demonstrated that this virus exhibited an HSV-2 latency phenotype, ..
  78. doi Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo
    Ruth Lyck
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Cereb Blood Flow Metab 29:1491-502. 2009
    ..In contrast, five AA transporter mRNAs with low expression in ppMBMECs, including y(+)Lat2, xCT, and Snat1, were upregulated by culture...
  79. ncbi Training subjective insomniacs to accurately perceive sleep onset
    R Downey
    Jerry L. Pettis Memorial Veterans Hospital, Loma Linda, California
    Sleep 15:58-63. 1992
    ..Each week consisted of a baseline lab night, a training lab night (treatment or control), a home (unmonitored night) and a recovery lab night...
  80. pmc The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine
    A Bröer
    Universitat Tubingen, Physiologisches Institut, Gmelinstr 5, 72076 Tubingen, Germany
    Biochem J 349:787-95. 2000
    ..Arginine release in mammalian cells can be mediated by two different transporters, y(+)LAT1 and y(+)LAT2. For insertion into the plasma membrane, these transporters have to be associated with the type-II membrane ..
  81. ncbi The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
    T Kageyama
    Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, 606 8507, Kyoto, Japan
    Brain Res 879:115-21. 2000
    ..Recently, it has been demonstrated that system L consists of two subunits, 4F2hc and either LAT1 or LAT2. 4F2hc/LAT1 and 4F2hc/LAT2 show different transport characteristics, while their distribution in the brain has not ..
  82. ncbi Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome
    J L Doyle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cytogenet Cell Genet 90:285-90. 2000
    ..of gene-prediction programs and cDNA isolation to identify the human and mouse orthologs of a novel gene (WBSCR15 and Wbscr15, respectively) residing within the genomic segment commonly deleted in WS...
  83. doi Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat
    Satoshi Uno
    Department of Pharmacy, School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashi Osaka, Osaka 577 8502, Japan
    Biopharm Drug Dispos 30:49-54. 2009
    ..In contrast, the mRNA levels of several ABC and SLC transporters, especially Mrp2, Bcrp, LAT2 and Oatp1a5, were significantly lower in the small intestines of AA rats compared with the controls on D7, though ..
  84. doi The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells
    Luciane P Capelo
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Thyroid 19:171-80. 2009
    ..the sodium taurocholate co-transporting polypeptide (NTCP), the L-type amino acid transporter 1 (LAT1) and 2 (LAT2), and the monocarboxylate transporter 8 (MCT8)...
  85. ncbi [Physical training of patients with sleep apnea]
    N Netzer
    Abteilung Sportmedizin,
    Pneumologie 51:779-82. 1997
    PURPOSE: It is a common question of sleep apnoea patients in the sleep lab whether they stand a chance to decrease the symptoms and severity of their disease by physical exercise...
  86. ncbi Characterization of amino acid transport system L in HTB-41 human salivary gland epidermoid carcinoma cells
    No Seung Park
    Oral Biology Research Institute and The Second Stage of BK21, Chosun University College of Dentistry, Gwangju 501 759, Korea
    Anticancer Res 28:2649-55. 2008
    ..The current study attempted to investigate the expression and functional characterization of amino acid transport system L in HTB-41 human submaxillary salivary gland epidermoid carcinoma cells...
  87. ncbi Cloning and functional characterization of a Na(+)-independent, broad-specific neutral amino acid transporter from mammalian intestine
    D P Rajan
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912 2100, USA
    Biochim Biophys Acta 1463:6-14. 2000
    ..This protein, called LAT2, consists of 535 amino acids and is distinct from LAT1 which also interacts with 4F2hc to induce system L-like ..
  88. doi Uptake of 3-[125I]iodo-alpha-methyl-L-tyrosine into colon cancer DLD-1 cells: characterization and inhibitory effect of natural amino acids and amino acid-like drugs
    Naoto Shikano
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ami Machi, Inashiki Gun, Ibaraki 300 0394, Japan
    Nucl Med Biol 37:197-204. 2010
    ..We examined 3-[(123)I]iodo-alpha-methyl-L-tyrosine ([(123)I]IMT) uptake and inhibition by amino acids and amino acid-like drugs in the human DLD-1 colon cancer cell line, to discuss correlation between the inhibition effect and structure...
  89. doi Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction
    L S Loubière
    School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Placenta 31:295-304. 2010
    ..We describe the ontogeny of the TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 in a large series (n = 110) of normal human placentae across gestation and describe their ..
  90. ncbi Evaluation of the Healthdyne NightWatch system to titrate CPAP in the home
    D P White
    National Jewish Center, Denver, Colorado, USA
    Sleep 21:198-204. 1998
    ..This group was compared with 30 patients who were diagnosed with sleep apnea using standard in-lab polysomnography and had CPAP titrated on a full night in the laboratory...
  91. doi Models of practice organisation using dental therapists: English case studies
    N Sun
    Institute of Psychology, Health and Society, University of Liverpool
    Br Dent J 211:E6. 2011
    ..A variety of models incorporating DTs in general practice teams exist, some of which may overcome the apparent delegation constraints embedded within this system of remuneration...
  92. pmc Primary and secondary thyroid hormone transporters
    Anita Kinne
    Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Roessle Str, 10, 13125 Berlin, Germany
    Thyroid Res 4:S7. 2011
    ..g. OATP1C1, OATP1A2, OPTP1A4) and the large neutral amino acid transporters (LAT1 and LAT2)...
  93. doi Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats
    Vanda Pinto
    Institute of Pharmacology and Therapeutics, Faulty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Mech Ageing Dev 132:298-304. 2011
    ..The urinary dopamine/renal delivery of l-DOPA ratio was increased in both rat strains with aging. LAT2 abundance was increased in aged WKY and SHR...
  94. pmc Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism
    M M Hamdi
    Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    J Physiol 589:3623-40. 2011
    ..Additionally, DHT treatment increased the expression of LAT2 and the phosphorylation of the EGFR in the fast-twitch fibre bundles and that of ERK1/2, RSK1/2 and ATF2 in both ..
  95. doi Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium
    Rebecca G Hu
    Department of Optometry and Vision Science, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
    Invest Ophthalmol Vis Sci 52:3345-53. 2011
    ....
  96. ncbi Isolation of monoclonal antibodies from cell containing hybridoma broth using a protein A coated adsorbent in expanded beds
    J Thommes
    Institut für Enzymtechnologie, Heinrich Heine Universitat Dusseldorf, Jüllich, Germany
    J Chromatogr A 752:111-22. 1996
    ..A scale up of the MAb purification is demonstrated from lab scale (250 mg MAb per purification cycle) to a small pilot scale (2 g MAb per cycle)...
  97. doi The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO
    J Duque-Afonso
    Department of Medicine, Division of Hematology Oncology, University of Freiburg, University Medical Center Freiburg, Freiburg, Germany
    Oncogene 30:3062-72. 2011
    ..Previously, we have identified a novel in vivo AML1/ETO target gene, LAT2 (NTAL/LAB/WBSCR5), which is involved in FcɛR I, c-Kit, B-cell and T-cell receptor signalling...
  98. ncbi A comparison of mental activity during sleep onset and morning awakening
    P C Cicogna
    Department of Psychology, University of Bologna, Italy
    Sleep 21:462-70. 1998
    ..One hundred forty-four dream reports and their association reports were collected from 36 subjects in a lab experimental design...
  99. ncbi Cloning and expression of a b(0,+)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria
    D P Rajan
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 274:29005-10. 1999
    ..to the other five known members of the 4F2 light chain family, namely LAT1 (4F2-lc1), y(+)LAT1 (4F2-lc2), y(+)LAT2 (4F2-lc3), xCT (4F2-lc4), and LAT2 (4F2-lc5)...
  100. doi Dietary protein composition influences abundance of peptide and amino acid transporter messenger ribonucleic acid in the small intestine of 2 lines of broiler chicks
    E R Gilbert
    Virginia Polytechnic Institute and State University, Department of Animal and Poultry Sciences, Blacksburg, 24061, USA
    Poult Sci 89:1663-76. 2010
    ..excitatory AA transporter 3 (EAAT3), Na(+)-independent cationic and Na(+)-dependent neutral AA transporter 2 (y(+)LAT2), L-type AA transporter 1 (LAT1), and cationic AA transporter 1 (CAT1)], and a digestive enzyme (aminopeptidase N) ..
  101. ncbi LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine
    G Rossier
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges s Lausanne, Switzerland
    J Biol Chem 274:34948-54. 1999
    ..In this study, we characterized a novel gpaAT, LAT2, for which mouse and human cDNAs were identified by expressed sequence tag data base searches...

Research Grants30

  1. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..the mechanism by which the MeHg-L-cysteine complex is transported on the L-type amino acid transporters LAT1 and LAT2. II...
  2. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2003
    ..We named this gene, LAB (Linker for activation of B cells). Our preliminary data showed that LAB shares many characteristics with LAT...
  3. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2007
    ..We named this gene, LAB (Linker for activation of B cells). Our preliminary data showed that LAB shares many characteristics with LAT...
  4. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2006
    ..We named this gene, LAB (Linker for activation of B cells). Our preliminary data showed that LAB shares many characteristics with LAT...
  5. Acetylcysteine: An Antidote for Methylmercury Poisoning
    TRACEY SIMMONS WILLIS; Fiscal Year: 2003
    ..Our recent work has shown that MeHg-L-cysteine is a substrate for the human amino acid transporters, LAT1 and LAT2, facilitating MeHg's rapid distribution in the body (Simmons-Willis et al. Biochem. Journal, in press)...
  6. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar Bulun; Fiscal Year: 2007
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  7. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  8. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2007
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  9. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  10. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2006
    ....
  11. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..The role of aromatase inhibitors in the treatment of endometriosis (in comparison with conventional treatments) will also be characterized in this model. ..