Lasp 1

Summary

Gene Symbol: Lasp 1
Description: LIM and SH3 protein 1
Alias: Lasp-1, MLN50, LIM and SH3 domain protein 1, metastatic lymph node gene 50 protein
Species: human
Products:     Lasp 1

Top Publications

  1. Tomasetto C, Regnier C, Moog Lutz C, Mattei M, Chenard M, Lidereau R, et al. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics. 1995;28:367-76 pubmed
    ..These findings further support the concept that human chromosome 17 specifically carries genes possibly involved in breast cancer progression. ..
  2. Wang B, Feng P, Xiao Z, Ren E. LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma. J Hepatol. 2009;50:528-37 pubmed publisher
    ..p53 transcriptionally represses Lasp1, which is a partner protein in affecting HCC cell motility. This suggests that p53 may play a role in influencing tumor metastasis through Lasp1. ..
  3. Mihlan S, Reis C, Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, et al. Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions. Oncogene. 2013;32:2107-13 pubmed publisher
    ..Finally, dephosphorylation of LASP-1 by phosphatase PP2B is suggested to relocalize the protein back to focal contacts. In summary, we define a new pathway for LASP-1 in tumor progression. ..
  4. Wang H, Li W, Jin X, Cui S, Zhao L. LIM and SH3 protein 1, a promoter of cell proliferation and migration, is a novel independent prognostic indicator in hepatocellular carcinoma. Eur J Cancer. 2013;49:974-83 pubmed publisher
    ..LASP-1 is a valuable marker of HCC progression. High cytosolic LASP-1 expression is associated with poor overall survival in HCC patients. ..
  5. Chiyomaru T, Enokida H, Kawakami K, Tatarano S, Uchida Y, Kawahara K, et al. Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer. Urol Oncol. 2012;30:434-43 pubmed publisher
    ..001). Our data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC. ..
  6. Zhao L, Wang H, Liu C, Liu Y, Wang X, Wang S, et al. Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1. Gut. 2010;59:1226-35 pubmed publisher
    ..In a previous study, comparative proteomic analysis was performed and LASP-1 was identified as a CRC-associated protein in those patients with CRC...
  7. Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004;279:20401-10 pubmed
    ..LIM-nebulette reveals a subcellular distribution at focal adhesions similar to Lasp-1. Thus, LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions. ..
  8. Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer H, Butt E. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun. 2004;324:308-16 pubmed
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1. ..
  9. Grunewald T, Kammerer U, Schulze E, Schindler D, Honig A, Zimmer M, et al. Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. Exp Cell Res. 2006;312:974-82 pubmed
    ..The data provide evidence for an essential role of LASP-1 in tumor cell growth and migration, possibly by influencing the localization of zyxin. ..

More Information

Publications89

  1. Raman D, Sai J, Neel N, Chew C, Richmond A. LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. PLoS ONE. 2010;5:e10050 pubmed publisher
    ..Thus the association between the chemokine receptors and LASP-1 suggests to the presence of a CXC chemokine receptor-LASP-1 pro-migratory module in cells governing the cell migration. ..
  2. Traenka J, Hauck C, Lewandrowski U, Sickmann A, Gambaryan S, Thalheimer P, et al. Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. Thromb Haemost. 2009;102:520-8 pubmed publisher
    ..Concomitant with adhesion, LASP-1 translocated from the cytosol along the arms of the pseudopodia into the leading lamellae of the spreading platelets, indicating a crucial role of the protein in platelet cytoskeleton rearrangement. ..
  3. Grunewald T, Kammerer U, Kapp M, Eck M, Dietl J, Butt E, et al. Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma. BMC Cancer. 2007;7:198 pubmed
    ..Increased expression of LASP-1 in vivo is present in breast carcinomas with higher tumor stage and therefore may be related with worse prognosis concerning patients' overall survival. ..
  4. Traenka C, Remke M, Korshunov A, Bender S, Hielscher T, Northcott P, et al. Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma. Cancer Res. 2010;70:8003-14 pubmed publisher
  5. Frietsch J, Grunewald T, Jasper S, Kammerer U, Herterich S, Kapp M, et al. Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. Br J Cancer. 2010;102:1645-53 pubmed publisher
    ..Our results provide evidence that nuclear LASP-1-positivity may serve as a negative prognostic indicator for long-term survival of breast cancer patients. ..
  6. Grunewald T, Kammerer U, Winkler C, Schindler D, Sickmann A, Honig A, et al. Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. Br J Cancer. 2007;96:296-305 pubmed
    ..The data provide evidence for an essential role of LASP-1 in tumour cell growth and migration, possibly through influencing zyxin localization. ..
  7. Chew C, Chen X, Parente J, Tarrer S, Okamoto C, Qin H. Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. J Cell Sci. 2002;115:4787-99 pubmed
  8. Schreiber V, Moog Lutz C, Regnier C, Chenard M, Boeuf H, Vonesch J, et al. Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. Mol Med. 1998;4:675-87 pubmed
    ..Altogether, our results show that Lasp-1 defines a new type of actin-binding protein and suggest that the protein may play a role in a signaling pathway involved in the organization of the cytoskeleton. ..
  9. Chew C, Parente J, Zhou C, Baranco E, Chen X. Lasp-1 is a regulated phosphoprotein within the cAMP signaling pathway in the gastric parietal cell. Am J Physiol. 1998;275:C56-67 pubmed
  10. Salvi A, Bongarzone I, Miccichè F, Arici B, Barlati S, De Petro G. Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells. Neoplasia. 2009;11:207-19 pubmed
    ..In summary, the proteomic identification of a set of uPA downstream proteins provides new insight into the function of uPA in HCC cells. ..
  11. Butt E, Gambaryan S, Göttfert N, Galler A, Marcus K, Meyer H. Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146. J Biol Chem. 2003;278:15601-7 pubmed
    ..Taken together, these data suggest that phosphorylation of LASP by cGK and cAK may be involved in cytoskeletal organization and cell motility. ..
  12. Tomasetto C, Moog Lutz C, Regnier C, Schreiber V, Basset P, Rio M. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. FEBS Lett. 1995;373:245-9 pubmed
    ..Thus, Lasp-1 defines a new LIM protein subfamily. ..
  13. Liu Y, Gao Y, Li D, He L, Iw L, Hao B, et al. LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p. Biomed Pharmacother. 2018;108:845-851 pubmed publisher
    ..Taken together, our results suggest that LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression. These data provide a new possible therapeutic target in glioma. ..
  14. Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, et al. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. J Exp Clin Cancer Res. 2018;37:253 pubmed publisher
    ..The observations in this study identify an important role for AFAP1-AS1 as a competing endogenous RNA (ceRNA) in NPC pathogenesis and indicate that it may serve as a potential target for cancer diagnosis and treatment. ..
  15. Zhang H, Chen F, Fan X, Lin C, Hao Y, Wei H, et al. Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery. Sci Rep. 2017;7:44910 pubmed publisher
    ..Thus, the proteomic analysis could accelerate our understanding of the mechanisms of HSC reversion on cessation of fibrogenic stimuli and provide new targets for antifibrotic liver therapy. ..
  16. Li W, Li H, Zhang L, Hu M, Li F, Deng J, et al. Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity. J Biol Chem. 2017;292:5801-5813 pubmed publisher
    ..These findings indicate that LINC00672 can influence LASP1 expression as a locus-restricted cofactor for p53-mediated gene suppression, thus impacting EC malignancies and chemosensitivity to paclitaxel. ..
  17. Niu Y, Shao Z, Wang H, Yang J, Zhang F, Luo Y, et al. LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling. Sci Rep. 2016;6:26112 pubmed publisher
    ..These findings indicate S100A11, combined with LASP1, plays a critical role in promoting CRC metastasis via its subcellular effectors, FLOT1 and histone H1. ..
  18. Šatrauskienė A, Navickas R, Laucevičius A, Huber H. Identifying differential miR and gene consensus patterns in peripheral blood of patients with cardiovascular diseases from literature data. BMC Cardiovasc Disord. 2017;17:173 pubmed publisher
    ..The analysis is easy to use and extendable upon further emergent literature as we provide an Excel sheet for this analysis to the community. ..
  19. Kong F, Zhu T, Li N, Cai Y, Zhou K, Wei X, et al. Bioinformatics analysis of the proteins interacting with LASP-1 and their association with HBV-related hepatocellular carcinoma. Sci Rep. 2017;7:44017 pubmed publisher
    ..Taken together, these results could help enrich our understanding of LASP-1 interactors and their relationships with HBV-related HCC. ..
  20. Li H, Xiang Z, Liu Y, Xu B, Tang J. MicroRNA-133b Inhibits Proliferation, Cellular Migration, and Invasion via Targeting LASP1 in Hepatocarcinoma Cells. Oncol Res. 2017;25:1269-1282 pubmed publisher
    ..In addition, overexpression of miR-133b inhibits tumor growth of HepG2 and Hep3B cells in vivo. Therefore, the miR-133b/LASP1 axis may become a potential target for the treatment of HCC. ..
  21. Benaich N, Woodhouse S, Goldie S, Mishra A, Quist S, Watt F. Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. Cell Rep. 2014;9:104-117 pubmed publisher
    ..Expression of miR-203 and its downstream effectors correlates with HNSCC overall survival outcomes, indicating the therapeutic potential of targeting this signaling axis. ..
  22. Butt E, Ebbing J, Bubendorf L, Ardelt P. Influence of hematuria and infection on diagnostic accuracy of urinary LASP1: a new biomarker for bladder carcinoma. Biomark Med. 2017;11:347-357 pubmed publisher
    ..59, 0.80, 0.80 and 0.59, respectively. Hematuria up to 200 erythrocytes/µl but not presence of leukocytes may be tolerated for this promising marker. ..
  23. Kang G, Yun H, Sun C, Park I, Lee S, Kwon J, et al. Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors. Oncotarget. 2016;7:6538-51 pubmed publisher
    ..These observations will allow us to determine the genetic basis of GISTs and will facilitate further investigation to develop new therapeutic options. ..
  24. Coumans J, Gau D, Poljak A, Wasinger V, Roy P, Moens P. Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses. OMICS. 2014;18:778-91 pubmed publisher
    ..Our data reported here might also offer innovative strategies for identification and validation of novel therapeutic targets and companion diagnostics for persons with, or susceptibility to, breast cancer. ..
  25. Zhong C, Chen Y, Tao B, Peng L, Peng T, Yang X, et al. LIM and SH3 protein 1 regulates cell growth and chemosensitivity of human glioblastoma via the PI3K/AKT pathway. BMC Cancer. 2018;18:722 pubmed publisher
    ..LASP1 may function as an oncogene in GBM and regulate cell proliferation and chemosensitivity in a PI3K/AKT-dependent mechanism. Thus, the LASP1/PI3K/AKT axis is a promising target and therapeutic strategy for GBM treatment. ..
  26. Dyshlovoy S, Otte K, Venz S, Hauschild J, Junker H, Makarieva T, et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin. Proteomics. 2017;17: pubmed publisher
    ..This work provides further insights into the molecular mechanisms underlying Rhiz bioactivity. Furthermore, our research is exemplary for the ability of proteomics to predict drug targets and mode of action of natural anticancer agents. ..
  27. Takeshita N, Mori M, Kano M, Hoshino I, Akutsu Y, Hanari N, et al. miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. Int J Oncol. 2012;41:1653-61 pubmed publisher
    ..The identification of a cancer network regulated by miR-203 could provide new insights into the potential mechanisms of the progression of ESCC. ..
  28. Jin B, Gao L, Li W, Chen J, Wen R, Wang J. [Expression of LIM and SH3 protein 1 in renal clear cell carcinoma and its effects on invasion and migration of renal clear cell carcinoma 786-O cells]. Zhonghua Zhong Liu Za Zhi. 2017;39:166-171 pubmed publisher
    ..05)?siRNA???????????????786?O??????????Vimentin???????????0.477±0.029?0.598±0.069?0.633±0.045?siRNA???Vimentin?????????(P<0.05)? ??? LASP1????????????????????????????????????EMT??????????????????????????. ..
  29. Gao Q, Tang L, Wu L, Li K, Wang H, Li W, et al. LASP1 promotes nasopharyngeal carcinoma progression through negatively regulation of the tumor suppressor PTEN. Cell Death Dis. 2018;9:393 pubmed publisher
    ..Our findings suggest that LASP1 has a crucial role in NPC progression via LASP1/PTEN/AKT axis, highlighting LASP1 as a therapeutic target for NPC. ..
  30. Wang B, Zhang L, Zhao L, Zhou R, Ding Y, Li G, et al. LASP2 suppresses colorectal cancer progression through JNK/p38 MAPK pathway meditated epithelial-mesenchymal transition. Cell Commun Signal. 2017;15:21 pubmed publisher
    ..All the findings indicated that LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy. ..
  31. Moazzeni H, Najafi A, Khani M. Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231. Mol Cell Probes. 2017;34:45-52 pubmed publisher
    ..Moreover, miR-96 may play an oncogenic role in breast cancer by suppressing the apoptosis through the regulation of ABCA1. ..
  32. Zhao L, Ding Y. [Impact of LASP-1 expression on proliferation and tumorigenesis of human colorectal cancer cell line SW480]. Zhonghua Bing Li Xue Za Zhi. 2010;39:830-4 pubmed
    ..LASP-1 gene expression enhances proliferation of colorectal cancer cells and may serve as a useful marker for colorectal cancer progression. ..
  33. Andrews M, Cursons J, Hurley D, Anaka M, Cebon J, Behren A, et al. Systems analysis identifies miR-29b regulation of invasiveness in melanoma. Mol Cancer. 2016;15:72 pubmed
    ..Computational scripts are available: http://github.com/uomsystemsbiology/LMMEL-miR-miner. ..
  34. Dejima T, Imada K, Takeuchi A, Shiota M, Leong J, Tombe T, et al. Suppression of LIM and SH3 Domain Protein 1 (LASP1) Negatively Regulated by Androgen Receptor Delays Castration Resistant Prostate Cancer Progression. Prostate. 2017;77:309-320 pubmed publisher
    b>LIM and SH3 domain protein 1 (LASP1) has been implicated in several human malignancies and has been shown to predict PSA recurrence in prostate cancer...
  35. Ruggieri V, Agriesti F, Tataranni T, Perris R, Mangieri D. Paving the path for invasion: The polyedric role of LASP1 in cancer. Tumour Biol. 2017;39:1010428317705757 pubmed publisher
    ..This may be decisive not only to optimize existing pharmacological regimes but also to delineate novel, more efficacious therapeutic and/or preventive approaches. ..
  36. Salvi A, Bongarzone I, Ferrari L, Abeni E, Arici B, De Bortoli M, et al. Molecular characterization of LASP-1 expression reveals vimentin as its new partner in human hepatocellular carcinoma cells. Int J Oncol. 2015;46:1901-12 pubmed publisher
    ..Our results suggest that LASP-1 mRNA overexpression may be mainly implicated in female HCCs and cirrhotic HCCs; and that LASP1 may play its role with vimentin in HCC cells. ..
  37. Zheng J, Yu S, Qiao Y, Zhang H, Liang S, Wang H, et al. LASP-1 promotes tumor proliferation and metastasis and is an independent unfavorable prognostic factor in gastric cancer. J Cancer Res Clin Oncol. 2014;140:1891-9 pubmed publisher
    ..Our study showed that LASP-1, overexpressed in gastric cancer and associated with poor prognosis, plays an important role in the growth and metastasis of gastric cancer. ..
  38. Zhang X, Liu Y, Fan C, Wang L, Li A, Zhou H, et al. Lasp1 promotes malignant phenotype of non-small-cell lung cancer via inducing phosphorylation of FAK-AKT pathway. Oncotarget. 2017;8:75102-75113 pubmed publisher
    Lasp1 (LIM and SH3 domain protein 1) promotes tumor proliferation and invasion in multiple cancer entities including non-small cell lung cancer (NSCLC). However, the molecular mechanism is uncertain to date...
  39. Bang M, Chen J. Roles of Nebulin Family Members in the Heart. Circ J. 2015;79:2081-7 pubmed publisher
    ..Additional in vivo models are required to provide further insights into the functions of nebulin family members in the heart. ..
  40. Wang H, An H, Wang B, Liao Q, Li W, Jin X, et al. miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway. Eur J Cancer. 2013;49:3924-35 pubmed publisher
    ..miR-133a may play a key role in CRC genesis and metastasis, which suggests its potential role in the molecular therapy of cancer. ..
  41. Shao Z, Cai Y, Xu L, Yao X, Shi J, Zhang F, et al. Loss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway. Sci Rep. 2016;6:25631 pubmed publisher
    ..Our research paves the path to future investigation of the LASP1-14-3-3σ axis as a target for novel anticancer therapies of advanced CRC. ..
  42. Zheng J, Wang F, Lu S, Wang X. LASP-1, regulated by miR-203, promotes tumor proliferation and aggressiveness in human non-small cell lung cancer. Exp Mol Pathol. 2016;100:116-24 pubmed publisher
    ..Moreover, LASP-1 was proved to be a direct target gene for miR-203. Our results suggest that LASP-1, mediated by miR-203, has crucial functions in the proliferation, migration and invasion of NSCLC. ..
  43. Stölting M, Wiesner C, van Vliet V, Butt E, Pavenstadt H, Linder S, et al. Lasp-1 regulates podosome function. PLoS ONE. 2012;7:e35340 pubmed publisher
    ..In summary, our data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function. ..
  44. Endres M, Kneitz S, Orth M, Perera R, Zernecke A, Butt E. Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1). Oncotarget. 2016;7:64244-64259 pubmed publisher
    ..The newly identified role of LASP1 in regulating matrix degradation by affecting MMP transcription and secretion elucidated the migratory potential of LASP1 overexpressing aggressive tumor cells in earlier studies. ..
  45. Wang W, Ji G, Xiao X, Chen X, Qin W, Yang F, et al. Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1. Oncotarget. 2016;7:68674-68687 pubmed publisher
    ..Our study provides an insight into the regulatory network in CRC cells, thus offering new targets for treating CRC patients. ..
  46. Wang L, Wang L, Wang X, Shang D, Yin S, Sun L, et al. MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1. Tumour Biol. 2016;37:15241-15252 pubmed
    ..on the proliferation, migration, invasion, and apoptosis of gastric cancer (GC) cells by targeting LIM and SH3 domain protein 1 (LASP1)...
  47. Sato M, Yoneyama M, Hatakeyama S, Funyu T, Suzuki T, Ohyama C, et al. The role of LIM and SH3 protein-1 in bladder cancer metastasis. Oncol Lett. 2017;14:4829-4834 pubmed publisher
    ..These results suggest that LASP-1 is important in invadopodia formation and cell proliferation of bladder cancer cells, promoting the malignant properties and resulting in poor-prognosis...
  48. Sui Y, Zhang X, Yang H, Wei W, Wang M. MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1. Oncol Rep. 2018;39:473-482 pubmed publisher
  49. Zhou R, Shao Z, Liu J, Zhan W, Gao Q, Pan Z, et al. COPS5 and LASP1 synergistically interact to downregulate 14-3-3σ expression and promote colorectal cancer progression via activating PI3K/AKT pathway. Int J Cancer. 2018;142:1853-1864 pubmed publisher
  50. Ardelt P, Grünemay N, Strehl A, Jilg C, Miernik A, Kneitz B, et al. LASP-1, a novel urinary marker for detection of bladder cancer. Urol Oncol. 2013;31:1591-8 pubmed publisher
    ..In the absence of urinary infection or gross hematuria, urinary LASP-1 level is a promising marker for transitional cell carcinoma. ..
  51. Tang R, Kong F, Hu L, You H, Zhang P, Du W, et al. Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1) expression to mediate proliferation and migration of hepatoma cells. Virol J. 2012;9:163 pubmed
    ..These results demonstrated that HBx could upregulate LASP-1 through PI3-K pathway to promote the proliferation and migration of hepatoma cells. ..
  52. Joo J, Lee S, Nah S, Kim Y, Kim D, Shim S, et al. Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility. J Psychiatr Res. 2013;47:105-12 pubmed publisher
    ..Our results suggest that LASP1 might be associated with NMDA receptor antagonism and schizophrenia susceptibility and, thus, might be involved in the pathophysiology of schizophrenia. ..
  53. Frietsch J, Kastner C, Grunewald T, Schweigel H, Nollau P, Ziermann J, et al. LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia. Oncotarget. 2014;5:5257-71 pubmed
    ..Recently, the LIM and SH3 domain protein 1 (LASP1) was identified as a component of a six gene signature that is strongly predictive for disease ..
  54. Segerer S, Bartmann C, Kaspar S, Müller N, Kapp M, Butt E, et al. The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells. Arch Gynecol Obstet. 2016;293:407-14 pubmed publisher
    ..This is the first study describing LASP-1 expression in CC cells. Detecting an affection of migratory processes after LASP-1 silencing, we propose that LASP-1 could impact on metastasis of CC cells. ..
  55. Vaman V S A, Poppe H, Houben R, Grunewald T, Goebeler M, Butt E. LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression. PLoS ONE. 2015;10:e0129219 pubmed publisher
    ..Collectively, we identified LASP1 as a hitherto unknown protein in melanocytes and as novel partner of dynamin in the physiological process of membrane constriction and melanosome vesicle release. ..
  56. Duvall Noelle N, Karwandyar A, Richmond A, Raman D. LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene. 2016;35:1122-33 pubmed publisher
    ..LASP-1 also directly bound to Snail1 which may stabilize Snail1. Thus, nuclear LASP-1 appears to functionally serve as a hub for the epigenetic machinery. ..
  57. Orth M, Cazes A, Butt E, Grunewald T. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. Oncotarget. 2015;6:26-42 pubmed
    ..In addition, we provide a comprehensive transcriptome analysis of published microarrays (n=2,780) that illustrates the expression profile of LASP1 in normal tissues and its overexpression in a broad range of human cancer entities. ..
  58. Shimizu F, Shiiba M, Ogawara K, Kimura R, Minakawa Y, Baba T, et al. Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer. PLoS ONE. 2013;8:e83187 pubmed publisher
    ..Our results suggested that overexpression of LASP-1 is linked closely to oral tumourigenicity and further provide novel evidence that LASP-1 plays an essential role in tumor cellular growth by mediating G2/M transition. ..
  59. Wang C, Zheng X, Shen C, Shi Y. MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells. J Exp Clin Cancer Res. 2012;31:58 pubmed publisher
    ..Meanwhile, the mRNA and protein levels of baculoviral IAP repeat-containing protein 5 (BIRC5) and Lim and SH3 domain protein 1 (LASP1) were measured...
  60. Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, et al. Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer. Cancer Sci. 2014;105:802-11 pubmed publisher
    ..Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis. ..
  61. Pan X, Wang Z, Wan B, Zheng Z. MicroRNA-206 inhibits the viability and migration of medulloblastoma cells by targeting LIM and SH3 protein 1. Exp Ther Med. 2017;14:3894-3900 pubmed publisher
    ..Our study highlights the importance of the miR-206/LASP1 in medulloblastoma...
  62. Giusti L, Mantua V, Da Valle Y, Ciregia F, Ventroni T, Orsolini G, et al. Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach. Mol Biosyst. 2014;10:1246-54 pubmed publisher
  63. Shi J, Guo J, Li X. Role of LASP-1, a novel SOX9 transcriptional target, in the progression of lung cancer. Int J Oncol. 2018;52:179-188 pubmed publisher
    ..Together, these findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion. ..
  64. He B, Yin B, Wang B, Chen C, Xia Z, Tang J, et al. Overexpression of LASP1 is associated with proliferation, migration and invasion in esophageal squamous cell carcinoma. Oncol Rep. 2013;29:1115-23 pubmed publisher
    ..LASP1 may play an important role in the pathogenesis of ESCC and shows promise as a treatment target in ESCC. ..
  65. Li H, Liu G, Pan K, Miao X, Xie Y. Methylation-induced downregulation and tumor suppressive role of microRNA-29b in gastric cancer through targeting LASP1. Oncotarget. 2017;8:95880-95895 pubmed publisher
    ..According to these data, miR-29b may be used as a potential therapeutic candidate for gastric cancer...
  66. Li Z, Chen Y, Wang X, Zhang H, Zhang Y, Gao Y, et al. LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway. Cancer Lett. 2016;372:239-50 pubmed publisher
    ..In conclusion, LASP-1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in GBC. LASP-1 could serve as a genetic treatment target in GBC patients. ..
  67. Jiang N, Jiang X, Chen Z, Song X, Wu L, Zong D, et al. MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2017;36:138 pubmed publisher
    ..The newly identified miR-203a-3p/LASP1 pathway provides further insights into the initiation and progression of NPC, which may represent a novel therapeutic target for NPC. ..
  68. Zhang H, Li Z, Chu B, Zhang F, Zhang Y, Ke F, et al. Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma. Tumour Biol. 2016;37:8305-15 pubmed publisher
  69. Hu S, Ran Y, Chen W, Zhang Y, Xu Y. MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1. Oncol Rep. 2017;38:1569-1578 pubmed publisher
    ..These results revealed that miR-326 suppressed the progression of HCC by directly targeting LASP1. Therefore, miR-326 may be used as a potential therapeutic target for the treatment of patients with HCC. ..
  70. Zhang X, Cai L, Zhou H, Liu Y, Fan C, Wang L, et al. Lasp2 enhances tumor invasion via facilitating phosphorylation of FAK and predicts poor overall survival of non-small cell lung cancer patients. Mol Carcinog. 2017;56:2558-2565 pubmed publisher
    ..Taken together, Lasp2 may facilitate tumor migration and invasion of NSCLCs through FAK-Snail/Zo-1 signaling pathway. Lasp2 may be a potential prognostic predictor of NSCLC patients. ..
  71. Wang H, Shi J, Luo Y, Liao Q, Niu Y, Zhang F, et al. LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression. Clin Cancer Res. 2014;20:5835-47 pubmed publisher
    ..These findings elucidate the central role of LASP1 in the TGFβ-mediated EMT process and suggest a potential target for the clinical intervention in patients with advanced colorectal cancer. ..
  72. Fang M, Du H, Han B, Xia G, Shi X, Zhang F, et al. Hypoxia-inducible microRNA-218 inhibits trophoblast invasion by targeting LASP1: Implications for preeclampsia development. Int J Biochem Cell Biol. 2017;87:95-103 pubmed publisher
    ..Furthermore, expression of LASP1 rescued the inhibitory effect of miR-218 on HTR-8/SVneo cell invasion. Together, these results indicated that miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion. ..
  73. Du Y, Zhao L, Chen L, Sang M, Li J, Ma M, et al. The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma. J Gastroenterol Hepatol. 2016;31:384-93 pubmed publisher
    ..miR-1 suppresses cell proliferation, invasiveness, metastasis, and progression of ESCC by binding its targeted genes LASP1 and TAGLN2. ..
  74. Gao W, Han J. Silencing of LIM and SH3 Protein 1 (LASP-1) Inhibits Thyroid Cancer Cell Proliferation and Invasion. Oncol Res. 2017;25:879-886 pubmed publisher
    ..We also demonstrated that LASP-1 silencing decreased the protein expression of p-PI3K and p-Akt. In conclusion, these findings suggest LASP-1 to be an oncogene and a potential therapeutic target in thyroid cancer. ..
  75. Sun W, Guo L, Shao G, Liu X, Guan Y, Su L, et al. Suppression of LASP-1 attenuates the carcinogenesis of prostatic cancer cell lines: Key role of the NF-?B pathway. Oncol Rep. 2017;37:341-347 pubmed publisher
  76. Zhao L, Wang H, Sun X, Ding Y. Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma. FEBS J. 2010;277:4195-204 pubmed publisher
    ..The pattern changes identified have the potential to be used for the design of marker panels for assistance in diagnostic and therapeutic strategies in CRC. ..
  77. Stone J, Merriman B, Cantor R, Geschwind D, Nelson S. High density SNP association study of a major autism linkage region on chromosome 17. Hum Mol Genet. 2007;16:704-15 pubmed
    ..34-2.29. ..
  78. Yang F, Zhou X, Du S, Zhao Y, Ren W, Deng Q, et al. LIM and SH3 domain protein 1 (LASP-1) overexpression was associated with aggressive phenotype and poor prognosis in clear cell renal cell cancer. PLoS ONE. 2014;9:e100557 pubmed publisher
    ..The results of the present study indicate that LASP-1 may serve as a prognostic biomarker for ccRCC patients and may be a promising target for the treatment of ccRCC. ..
  79. Zhao T, Ren H, Li J, Chen J, Zhang H, Xin W, et al. LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. Cancer Res. 2015;75:111-9 pubmed publisher
    ..Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC. ..
  80. Li P, Hu J, Ma C, Ma H, Yao J, Chen L, et al. Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1. Oncotarget. 2017;8:34164-34176 pubmed publisher
    ..Our results suggest that PVT1 promote ESCC progression via functioning as a molecular sponge for miR-203 and LASP1 and provide the first evidence of dysregulated PVT1/miR-203/LASP1 axis in ESCC. ..