LARS2

Summary

Gene Symbol: LARS2
Description: leucyl-tRNA synthetase 2, mitochondrial
Alias: LEURS, PRLTS4, leucine tRNA ligase 2, mitochondrial, leucine tRNA ligase 2, mitocondrial, leucine translase
Species: human

Top Publications

  1. ncbi Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
    Leen M 't Hart
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
    Diabetes 54:1892-5. 2005
  2. pmc Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Hyejeong Park
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    RNA 14:2407-16. 2008
  3. ncbi Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
    A Szeles
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 20:329-36. 1997
  4. ncbi A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3
    H Kiss
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Hum Genet 105:552-9. 1999
  5. pmc Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
    Ronghua Li
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 30:2147-54. 2010
  6. pmc How does poverty beget poverty?
    Linda S Pagani
    Ecole de Psychoéducation, Centre de Recherche de l Hôpital Sainte Justine, Universite de Montreal, Montreal, Quebec
    Paediatr Child Health 12:693-7. 2007
  7. ncbi Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 346:57-71. 2005
  8. pmc Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity
    Aswini K Betha
    Department of Biology and Biochemistry, 369 Science and Research Building II, University of Houston, Houston, Texas 77204 5001, USA
    Biochemistry 46:6258-67. 2007
  9. pmc A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
    Stanley W Lue
    Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 46:4466-72. 2007
  10. pmc A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases
    Jennifer L Hsu
    Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 S Mathews Ave, Urbana, IL 61801 3732, USA
    J Mol Biol 376:482-91. 2008

Research Grants

  1. tRNA Synthesis Fidelity Mechanisms
    Susan A Martinis; Fiscal Year: 2010
  2. tRNA Synthesis Fidelity Mechanisms
    Susan A Martinis; Fiscal Year: 2010
  3. tRNA Synthesis Fidelity Mechanisms
    SUSAN MARTINIS; Fiscal Year: 2007
  4. Biochemistry of lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2010
  5. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2007
  6. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2006
  7. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications137 found, 100 shown here

  1. ncbi Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
    Leen M 't Hart
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
    Diabetes 54:1892-5. 2005
    ..In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes...
  2. pmc Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Hyejeong Park
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    RNA 14:2407-16. 2008
    ..This suppression of a tRNA gene mutation by increasing the steady-state levels of its cognate aminoacyl-tRNA synthetase is a model for potential therapies for human pathogenic tRNA mutations...
  3. ncbi Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
    A Szeles
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 20:329-36. 1997
    ..We have defined a common eliminated region of approximately 1.6 cM (designated as CER1) inside the 7 cM CER described earlier. CER1 is flanked distally by D3S1029 and proximally by D3S643...
  4. ncbi A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3
    H Kiss
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Hum Genet 105:552-9. 1999
    ..The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression...
  5. pmc Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
    Ronghua Li
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 30:2147-54. 2010
    ..mechanism of the A3243G mutation and whether the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid (cybrid) cells carrying the A3243G mutation corrects the mitochondrial dysfunctions...
  6. pmc How does poverty beget poverty?
    Linda S Pagani
    Ecole de Psychoéducation, Centre de Recherche de l Hôpital Sainte Justine, Universite de Montreal, Montreal, Quebec
    Paediatr Child Health 12:693-7. 2007
    ..Puisque leur rendement n'équivaut pas à celui de leurs camarades des classes moyennes, ces enfants sont plus vulnérables à l'échec scolaire et aux troubles de ..
  7. ncbi Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 346:57-71. 2005
    The editing domains of the closely homologous leucyl, isoleucyl, and valyl-tRNA synthetases (LeuRS, IleRS, and ValRS, respectively) contribute to accurate aminoacylation, by hydrolyzing misformed non-cognate aminoacyl-tRNAs...
  8. pmc Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity
    Aswini K Betha
    Department of Biology and Biochemistry, 369 Science and Research Building II, University of Houston, Houston, Texas 77204 5001, USA
    Biochemistry 46:6258-67. 2007
    Protein synthesis and its fidelity rely upon the aminoacyl-tRNA synthetases. Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) have evolved a discrete editing domain called CP1 that ..
  9. pmc A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
    Stanley W Lue
    Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 46:4466-72. 2007
    Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high aminoacylation fidelity without a functional editing active site, representing a rare example of a class I aminoacyl-tRNA synthetase (aaRS) that does not proofread ..
  10. pmc A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases
    Jennifer L Hsu
    Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 S Mathews Ave, Urbana, IL 61801 3732, USA
    J Mol Biol 376:482-91. 2008
    A unique C-terminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation. In one exception, the enzymatic activity of yeast mitochondrial LeuRS is actually impeded by its own C-terminal domain...
  11. pmc Cross-species aminoacylation of tRNA with a long variable arm between Escherichia coli and Saccharomyces cerevisiae
    A Soma
    Department of Biology, Faculty of Science, Hirosaki University, Hirosaki 036 8561, Japan Biochemistry and Biotechnology, Faculty of
    Nucleic Acids Res 26:4374-81. 1998
    ..Both SerRS and LeuRS from E...
  12. ncbi Functional association between three archaeal aminoacyl-tRNA synthetases
    Mette Praetorius-Ibba
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 282:3680-7. 2007
    ..aaRSs have also been reported in archaea, including a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter thermautotrophicus that enhances tRNA(Pro) aminoacylation...
  13. ncbi Mutational analysis of the antagonist-binding site of the histamine H(1) receptor
    K Wieland
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Division of Medicinal Chemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 274:29994-30000. 1999
    ..M., Timmerman, H., Leurs, H., Nederkoorn, P. H. J., Smit, M. J., and Donne-Op den Kelder, G. M. (1995) J. Comp. Aid. Mol. Design...
  14. pmc An aminoacyl-tRNA synthetase:elongation factor complex for substrate channeling in archaeal translation
    Corinne D Hausmann
    Department of Microbiology, Ohio State Biochemistry Program, and Ohio State RNA Group, The Ohio State University, Columbus, Ohio 43210 1292, USA
    Nucleic Acids Res 35:6094-102. 2007
    ..EF-1alpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM)...
  15. doi Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain
    Peng Yao
    State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 283:22591-600. 2008
    Leucyl-tRNA synthetase (LeuRS) contains an editing domain that discriminates leucine from noncognate amino acids to ensure translational fidelity...
  16. pmc The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 283:36608-16. 2008
    Leucyl-tRNA synthetase (LeuRS) has an insertion domain, called connective peptide 2 (CP2), either directly preceding or following the editing domain (CP1 domain), depending on the species...
  17. pmc An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing
    Seung Bae Rho
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    EMBO J 21:6874-81. 2002
    Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron and collaborates with the bI4 maturase to aid excision of the group I intron...
  18. doi A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, People s Republic of China
    Biochemistry 48:1340-7. 2009
    Leucyl-tRNA synthetase (LeuRS) catalyzes the esterification of the tRNA(Leu) isoacceptor with leucine. It contains a large insertion domain, connective peptide 1 (CP1), for amino acid editing...
  19. pmc Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylation
    Mette Praetorius-Ibba
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 280:26099-104. 2005
    ..proteins identified included components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS)...
  20. doi Roughness analysis of the skin as a secondary evaluation criterion in addition to visual scoring is sufficient to evaluate ethnic differences in wrinkles
    T Fujimura
    Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
    Int J Cosmet Sci 31:361-7. 2009
    ..We conclude that roughness analysis of the skin is an important secondary evaluation criterion to visual scoring necessary to evaluate ethnic differences of wrinkles...
  21. pmc Dynamical networks in tRNA:protein complexes
    Anurag Sethi
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:6620-5. 2009
    ..pathways in a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex...
  22. pmc Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps
    Peng Yao
    State Key Laboratory of Molecular Biology Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, People s Republic of China
    Nucleic Acids Res 36:2728-38. 2008
    ..tRNA(Leu) recognition sets and their evolution, the recognition of tRNA(Leu) by the leucyl-tRNA synthetase (LeuRS) from the primitive hyperthermophilic bacterium Aquifex aeolicus was studied by RNA probing and mutagenesis...
  23. doi [Neuroplasticity: from physiological adaptation to the concept of therapeutic plasticity]
    Brigitte Onteniente
    INSERM, UMR 894, Centre de Recherches en Psychiatrie et Neurosciences, 2ter rue d Alesia, 75014 Paris, France
    J Soc Biol 203:107-11. 2009
    ....
  24. pmc Molecular cloning and nucleotide sequence of the gene for Escherichia coli leucyl-tRNA synthetase
    M Hartlein
    European Molecular Biology Laboratory, Grenoble, France
    Nucleic Acids Res 15:10199-210. 1987
    ..coli gene bank DNA. The resulting clones overexpress leucyl-tRNA synthetase (LeuRS) by a factor greater than 50. The DNA sequence of the complete coding regions was determined...
  25. doi Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases
    Xiao Long Zhou
    Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochem J 429:505-13. 2010
    b>LeuRS (leucyl-tRNA synthetase) catalyses the esterification of tRNAsLeu with leucine...
  26. ncbi [In Process Citation]
    Mathieu Molimard
    , CHU de Bordeaux, Bordeaux, France
    Therapie 64:203-7. 2009
    ..b>Leurs données sont utilisées notamment lors d'une réévaluation anticipée ou lors du renouvellement d'..
  27. pmc Structural and functional mapping of the archaeal multi-aminoacyl-tRNA synthetase complex
    Corinne D Hausmann
    Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    FEBS Lett 582:2178-82. 2008
    Methanothermobacter thermautotrophicus contains a multi-aminoacyl-tRNA synthetase complex (MSC) of LysRS, LeuRS and ProRS. Elongation factor (EF) 1A also associates to the MSC, with LeuRS possibly acting as a core protein...
  28. pmc Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
    Xin Chen
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 39:235-47. 2011
    ..Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein amino acids and then mischarge tRNA(Leu)...
  29. pmc tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase
    Min Tan
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 285:3235-44. 2010
    ..In this work we studied the different editing pathways of class Ia leucyl-tRNA synthetase (LeuRS)...
  30. pmc RNA and protein requirements for incorporation of the Pol protein into foamy virus particles
    Katrin Peters
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Versbacher Str 7, 97078 Wurzburg, Germany
    J Virol 79:7005-13. 2005
    ..We previously showed that the packaging of (pre)genomic RNA is essential for Pol encapsidation (M. Heinkelein, C. Leurs, M. Rammling, K. Peters, H. Hanenberg, and A. Rethwilm, J. Virol. 76:10069-10073, 2002)...
  31. ncbi Leucyl-tRNA synthetase consisting of two subunits from hyperthermophilic bacteria Aquifex aeolicus
    Min Gang Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    J Biol Chem 277:41590-6. 2002
    In a hyperthermophilic bacterium, Aquifex aeolicus, leucyl-tRNA synthetase (LeuRS) consists of two non-identical polypeptide subunits (alpha and beta), different from the canonical LeuRS, which has a single polypeptide chain...
  32. pmc Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution
    Ming Wei Zhao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, PR China
    EMBO J 24:1430-9. 2005
    ..the isolated editing domain of leucyl-tRNA synthetase from the deep-rooted bacterium Aquifex aeolicus (alphabeta-LeuRS) catalyzes the hydrolytic editing of both mischarged tRNA(Leu) and minihelix(Leu)...
  33. ncbi Major biocontrol of plant tumors targets tRNA synthetase
    John S Reader
    Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 309:1533. 2005
    ..We demonstrate that this biocontrol agent targets A. tumefaciens leucyl-tRNA synthetase (LeuRS), an essential enzyme for cell viability, while the agent itself survives by having a second, self-protective copy ..
  34. pmc Two distinct domains of the beta subunit of Aquifex aeolicus leucyl-tRNA synthetase are involved in tRNA binding as revealed by a three-hybrid selection
    Yong Gang Zheng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Nucleic Acids Res 32:3294-303. 2004
    The Aquifex aeolicus alphabeta-LeuRS is the only known heterodimeric class Ia aminoacyl-tRNA synthetase. In this study, we investigated the function of the beta subunit which is believed to bind tRNA(Leu)...
  35. ncbi Leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus recognizes minihelices
    Min Gang Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 279:32151-8. 2004
    ..Although Escherichia coli or Homo sapiens cytoplasmic leucyl-tRNA synthetase (LeuRS) is unable to charge the cognate minihelix or microhelix, we show here that minihelix(Leu) is efficiently charged ..
  36. ncbi Leucyl-tRNA synthetase from the extreme thermophile Aquifex aeolicus has a heterodimeric quaternary structure
    Masaki Gouda
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, 501 1193, Gifu, Japan
    FEBS Lett 518:139-43. 2002
    ..genome sequence of a hyper thermophile Aquifex aeolicus suggests that the gene for leucyl-tRNA synthetases (LeuRS) is probably split into two pieces (leuS and leuS')...
  37. ncbi Towards a phosphoproteome map of Corynebacterium glutamicum
    Anne K Bendt
    Institut fur Biochemie, Universitat zu Koln, Zulpicher Strasse 47, D 50674 Köln, Germany
    Proteomics 3:1637-46. 2003
    ..Both detection techniques were used to create a phosphoproteome map. Additionally, the influence of nitrogen deprivation on the phosphoproteome of C. glutamicum was investigated...
  38. ncbi [In Process Citation]
    Geneviève Dulude
    Universite de Montreal
    Can J Diet Pract Res 74:119-23. 2013
    ..The goal of this study is to examine the relationships between mothers' food practices and the diets of their preschool children...
  39. pmc Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria
    Vincent Hernandez
    Anacor Pharmaceuticals Inc, Palo Alto, CA, USA
    Antimicrob Agents Chemother 57:1394-403. 2013
    ..We have previously identified a new a way to inhibit an aminoacyl-tRNA synthetase, leucyl-tRNA synthetase (LeuRS), in fungi via the oxaborole tRNA trapping (OBORT) mechanism...
  40. pmc Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase
    Wei Yan
    State Key Laboratory of Molecular Biology, Center for RNA Research, Institute of Biochemistry and Cell Biology, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
    Nucleic Acids Res 41:4988-98. 2013
    ..However, the LeuRS from Mycoplasma mobile (MmLeuRS) has a tetrapeptide GKDG instead of the LSD...
  41. pmc Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
    Qing Hua Hu
    1 State Key Laboratory of Molecular Biology, Center for RNA Research, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China 2
    Sci Rep 3:2475. 2013
    ..The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation and is an attractive drug target for antimicrobial development...
  42. pmc Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
    Li Li
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 110:3817-22. 2013
    ..A high-resolution X-ray crystal structure shows that M. mobile LeuRS structurally overlaps with other LeuRS cores...
  43. ncbi Mechanism of the activation step of the aminoacylation reaction: a significant difference between class I and class II synthetases
    Sindrila Dutta Banik
    Department of Chemistry, University of Kalyani, Kalyani, Nadia, West Bengal, 741235, India
    J Biomol Struct Dyn 30:701-15. 2012
    ..The class I aaRSs investigated are GluRS, GlnRS, TyrRS, TrpRS, LeuRS, ValRS, IleRS, CysRS, and MetRS and class II aaRSs investigated are HisRS, LysRS, ProRS, AspRS, AsnRS, AlaRS, ..
  44. pmc [Primitive peritonitis: real entity but difficult to diagnose]
    Rajae Yamou
    Service des urgences chirurgicales viscérales, Hopital Ibn Sina, Rabat, Maroc
    Pan Afr Med J 12:83. 2012
    ..Elles simulent les péritonites secondaires. C'est pourquoi leur diagnostic ne peut être que peropératoire. Nous rapportons deux cas de péritonites primitives dans le but de discuter leurs aspects diagnostique et thérapeutiques.
  45. pmc [[Study of factors related to adherence to antiretroviral therapy among patients followed at HIV/AIDS Unit in the District Hospital of Dschang, Cameroon]]
    Francois Xavier Mbopi-Keou
    Laboratoire National de Santé Hygiène Mobile, Ministere de la Sante Publique, Yaounde, Cameroun et Faculté de Médecine et des Sciences Biomédicales, Universite de Yaounde I, Yaounde, Cameroun
    Pan Afr Med J 12:55. 2012
    ..a été évaluée sur la base des déclarations des patients et sur la régularité du renouvellement de leurs ordonnances (observance calculée)...
  46. doi 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects
    Yan Hong Zhang
    Shanghai Key Laboratory of Functional Materials Chemistry, and Research Center of Analysis and Test, East China University of Science and Technology, Shanghai 200237, PR China
    Fitoterapia 83:1281-5. 2012
    An aqueous ethanol extract of Artemisia argyi inhibited the aminoacylation activity of LeuRS from Giardia lamblia (GlLeuRS)...
  47. pmc Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle
    Arianna Montanari
    Department of Biology and Biotechnology, Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy
    RNA 17:1983-96. 2011
    ..On the contrary, both the cognate IleRS and the noncognate LeuRS and ValRS are endowed with suppressing activities toward both mutations...
  48. ncbi Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
    G Eriani
    Laboratoires de Biochimie, IBMC du CNRS, Strasbourg, France
    Nature 347:203-6. 1990
    ..of the 18 known aaRS, only 9 referred to as class I synthetases (GlnRS, TyrRS, MetRS, GluRS, ArgRS, ValRS, IleRS, LeuRS, TrpRS), display two short common consensus sequences ('HIGH' and 'KMSKS') which indicate, as observed in three ..
  49. doi Human and peoples' rights: social representations among Cameroonian students
    Anna Maija Pirttilä-Backman
    University of Helsinki, Helsinki, Finland
    Int J Psychol 44:459-67. 2009
    ..Men may feel frustrated in the context of political liberalization because the freedoms are more theoretical than fulfilled; the economic crises and cultural changes have hindered their economic domination and their prerogatives...
  50. doi The importance of values in predicting Turkish youth's opinions about the European Union in light of the Copenhagen Political Criteria
    M Ersin Kuşdil
    Uludag University, Bursa, Turkey
    Int J Psychol 43:988-96. 2008
    ..As for nationalism, the results showed that this variable was related negatively to reduction of the military influence, improvement of human rights and liberties, improvement of minority rights; and positively to scepticism...
  51. doi Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editing
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai 200031, People s Republic of China
    Biochem Biophys Res Commun 386:510-5. 2009
    Leucyl-tRNA synthetase (LeuRS) is responsible for the Leu-tRNA(Leu) synthesis...
  52. doi Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation
    Daniel Weiss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Muenster, Germany
    Mol Carcinog 50:680-8. 2011
    ..genes (TIMP3, CDH1, CDKN2A, DAPK1, transcription factor 21 (TCF21), CD44, MLH1, MGMT, RASSF1, cyclin A1 (CCNA1), LARS2, and CEBPA) was evaluated by methylation-specific polymerase chain reaction in 55 primary HNSCC and 31 controls...
  53. ncbi La création d'une Section étudiante dans le CIM
    Sagar Dugani
    Clin Invest Med 33:E3. 2010
    ..de communication et c'est donc par le biais de la Section étudiante du CIM que les étudiants MD+, leurs superviseurs ainsi que les responsables de programmes MD+ seront en mesure de mettre en valeur des sujets touchant ..
  54. doi Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalyst
    Yohsuke Hagiwara
    Center for Computational Sciences, University of Tsukuba, Tennodai 1 1 1, Tsukuba Science City, Ibaraki 305 8577, Japan
    J Am Chem Soc 132:2751-8. 2010
    ..We investigated theoretically the mechanism of the editing reaction for a class I enzyme, leucyl-tRNA synthetase (LeuRS), complexed with a misaminoacylated tRNA(Leu), employing ab initio hybrid quantum mechanical/molecular mechanical ..
  55. pmc Relationship between tap water hardness, magnesium, and calcium concentration and mortality due to ischemic heart disease or stroke in The Netherlands
    Lina J Leurs
    Maastricht University, GROW School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht, The Netherlands
    Environ Health Perspect 118:414-20. 2010
    ..Conflicting results on the relationship between the hardness of drinking water and mortality related to ischemic heart disease (IHD) or stroke have been reported...
  56. doi [Optimizing the relational aspects of orthodontics: the foundations of successful cooperation]
    Edmond Binhas
    Institut Binhas, BP 20057, 5 rue de Copenhague, 13742 Vitrolles Cedex, France
    Orthod Fr 80:279-90. 2009
    ..As a consequence, there can be repercussions affecting the proper economic growth of the practice. In order to find the most appropriate solutions to this problem, orthodontists must first have a solid understanding of just what it is...
  57. pmc A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase
    Yan Ling Joy Pang
    Department of Biochemistry, University of Illinois, 419 Roger Adams Laboratory, Box B 4, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    Biochemistry 48:8958-64. 2009
    Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site...
  58. doi Long-term immigrant adaptation: eight-year follow-up study among immigrants from Russia and Estonia living in Finland
    Inga Jasinskaja-Lahti
    Department of Social Psychology, University of Helsinki, Helsinki, Finland
    Int J Psychol 43:6-18. 2008
    ..En huit ans, les répondants avaient amélioré leurs habiletés en finlandais sur le marché de travail...
  59. doi [Misuse of psychotropic medications in a population of subjects held for custody in the city of Paris]
    Isabelle Sec
    Urgences Médico Judiciaires, Hotel Dieu, faculté Paris Descartes, Universite Paris V, Paris, France
    Therapie 64:129-34. 2009
    ..Identify which psychotropic medications are misused and peddled in a population of subjects held for custody in the city of Paris...
  60. doi Protein signatures (molecular synapomorphies) that are distinctive characteristics of the major cyanobacterial clades
    Radhey S Gupta
    Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Int J Syst Evol Microbiol 59:2510-26. 2009
    ..and 1 aa deletion in the RpoC protein); a clade of the low-B/A ecotype Prochlorococcus strains (5 aa deletion in LeuRS and 1 aa insert in the Ffh protein); a clade consisting of the Nostocales species/strains (subclass ..
  61. pmc [[Screening for cardiovascular disease among students at the University of Douala and influence of sport and physical activity]]
    Marielle Epacka Ewane
    hôpital général de Douala, Cameroun
    Pan Afr Med J 11:77. 2012
    ..CONCLUSION: La présence des MCV et leurs facteurs de risque mis en évidence dans cette étude réalisée en milieu estudiantin camerounais interpelle à ..
  62. doi Leucyl-tRNA synthetase controls TORC1 via the EGO complex
    Grégory Bonfils
    Department of Biology, Division of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
    Mol Cell 46:105-10. 2012
    ..We find that the leucyl-tRNA synthetase (LeuRS) Cdc60 interacts with the Rag GTPase Gtr1 of the EGOC in a leucine-dependent manner...
  63. pmc [[Quality of certificates of assault and battery on adults in Dakar and Diourbel, Senegal]]
    Mohamed Maniboliot Soumah
    Service de médecine légale, Faculte de Medecine, Pharmacie et Odontostomatologie, Université Cheikh Anta Diop UCAD, Dakar, Senegal
    Pan Afr Med J 10:59. 2011
    ..de Dakar et de Diourbel, d'apprécier l'évaluation de l'Incapacité Totale de Travail fixée par les médecins et leurs implications judiciaires...
  64. doi Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690
    Xiao Long Zhou
    State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, People s Republic of China
    Biochem J 430:325-33. 2010
    ..The CP1 (connective peptide 1) domain of LeuRS (leucyl-tRNA synthetase) contains the editing active site, which is the proven target for the broad-spectrum drug ..
  65. doi Acculturation and its determinants among adult immigrants in France
    Hisham Motkal Abu-Rayya
    School of Psychology, University of Sydney, Sydney, Australia
    Int J Psychol 44:195-203. 2009
    ..Findings revealed also that those identifying with their home country/ethnic group recorded relatively higher degrees of maladjustment than those asserting a French identification...
  66. doi Effects of country size and language similarity on international attitudes: a six-nation study
    Jan Pieter van Oudenhoven
    University of Groningen, The Netherlands
    Int J Psychol 45:48-55. 2010
    ..Les nations voisines linguistiquement similaires qui diffèrent en taille sont souvent asymétriques dans leurs relations attitudinales l'une envers l'autre: les citoyens des nations plus petites tendent à voir les nations ..
  67. doi The willingness to relocate to another country: the impact of cultural similarity, destination safety, and financial incentive
    Michael R Wagner
    Department of Organization and Leadership, Teachers College, Columbia University, New York, NY 10027, USA
    Int J Psychol 44:257-65. 2009
    ..Against expectations, there was no interaction between financial incentives and safety. Destination safety perceptions were relatively strong determinants of willingness to relocate...
  68. pmc Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing
    Vrajesh A Karkhanis
    Department of Biochemistry, University of Illinois at Urbana Champaign, 600 S Mathews Ave, 419 Roger Adams Laboratory, Box B 4, Urbana, Illinois 61801 3732, USA
    J Bacteriol 189:8765-8. 2007
    Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation...
  69. doi Parent-child conflict and psychological maladjustment: a mediational analysis with reciprocal filial belief and perceived threat
    Kuang Hui Yeh
    Academia Sinica, Taipei, Taiwan
    Int J Psychol 45:131-9. 2010
    ..le conflit parent-enfant nuit aux peceptions des adolescents de leur relation avec les parents ainsi que de leurs auto-perceptions dans le cadre de leur évaluation cognitive...
  70. doi A comparison of fathers' and mothers' contributions in the prediction of academic performance of school-age children in Hong Kong
    Vicky C W Tam
    Department of Education Studies, Hong Kong Baptist University, Hong Kong
    Int J Psychol 44:147-56. 2009
    ..Investigations should also explore other cognitive and noncognitive domains of child outcome, different child age groups, as well as Chinese populations in various geographical regions...
  71. pmc [[Assessment of patients' satisfaction in obstetrics and gynecology ward in Sousse, Tunisia]]
    Iheb Bougmiza
    Département de Médecine Communautaire Faculté de Médecine Ibn El Jazzar, Université de Sousse, Tunisie
    Pan Afr Med J 8:44. 2011
    ..de qualité moindre ou de qualité similaire, et celles qui avaient l'intention de recommander l'hôpital à leurs proches...
  72. doi A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activity
    Min Tan
    State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
    Biochem J 443:477-84. 2012
    ..For LeuRS (leucyl-tRNA synthetase), the CP1 (connective peptide 1) domain is the editing domain responsible for hydrolysing ..
  73. doi Sex differences in psychological effects of exercise
    F Hülya Aşçı
    Baskent University, Sport Sciences Department, Ankara, Turkiye
    Int J Psychol 44:313-20. 2009
    ..Exerciser males improved their personal self and physical self scores more than female exercisers and male and female nonexercisers throughout the 10-week period (p<.05)...
  74. doi Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents
    Dazhong Ding
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
    J Med Chem 54:1276-87. 2011
    ..brucei parasite growth inhibition activity. This is the first time that TbLeuRS inhibitors are reported, and this study suggests that leucyl-tRNA synthetase (LeuRS) could be a potential target for antiparasitic drug development.
  75. doi The adaptation of Chinese adolescents in two societies: a comparison of Chinese adolescents in Hong Kong and Australia
    Cynthia Leung
    Department of Educational Psychology, Counselling and Learning Needs, The Hong Kong Institute of Education, Hong Kong
    Int J Psychol 44:170-8. 2009
    ..Migrant adolescents reported better psychological and sociocultural adaptation than their nonmigrant counterparts. The results were discussed in relation to the social and educational systems of the two societies...
  76. doi The relationship between three types of aggression and peer relations in elementary school children
    Katsuyuki Yamasaki
    Department of Human Development, Naruto University of Education, Tokushima, Japan
    Int J Psychol 44:179-86. 2009
    ..The implications of these findings with respect to internalizing and externalizing problem behaviours for aggressive children are discussed...
  77. doi Individual differences in coping with criticism of one's physical appearance among Taiwanese students
    Luo Lu
    Department of Business Administration, National Taiwan University, Taipei, Taiwan, Republic of China
    Int J Psychol 44:274-81. 2009
    ..Possible influences of the Chinese collectivist culture on people's responses to criticism were also delineated, such as valuing interpersonal harmony and face-work in social situations...
  78. doi Personal investment, culture and learning: insights into school achievement across Anglo, Aboriginal, Asian and Lebanese students in Australia
    Dennis M McInerney
    Centre for Research in Pedagogy and Practice, National Institute of Education, Nanyang Technological University, Singapore
    Int J Psychol 43:870-9. 2008
    ..Across cultural groups, students' mastery goal and sense of purpose were consistently found to be significant predictors of their intention for further education, positive affect for schooling, and valuing of schooling...
  79. doi Self- and other-estimates of multiple abilities in Britain and Turkey: a cross-cultural comparison of subjective ratings of intelligence
    Adrian Furnham
    Department of Psychology, University College London, London, UK
    Int J Psychol 44:434-42. 2009
    ..Results are discussed in terms of the growing literature in the field...
  80. doi Contextualized self: when the self runs into social dilemmas
    Chang Jiang Liu
    Chinese Academy of Sciences, Beijing, China, and Shenyang Normal University, Shenyang, China
    Int J Psychol 44:451-8. 2009
    ..The results demonstrate that the self can be contextualized and embedded in the social contexts and symbolic systems within which people live...
  81. doi Confidence judgments in real classroom settings: monitoring performance in different types of tests
    Moisés Kirk de Carvalho Filho
    Graduate School of Education, Kyoto University, Kyoto, Japan
    Int J Psychol 44:93-108. 2009
    ..In addition, based on the results obtained, specific suggestions on how to increase the metacognitive awareness of university students through instruction and on how to improve their academic assessment are provided...
  82. doi Effects of received and mobilized support on recipients' and providers' self-efficacy beliefs: a 1-year follow-up study with patients receiving radical prostatectomy and their spouses
    Nina Knoll
    Charite Universitatsmedizin Berlin, Germany
    Int J Psychol 44:129-37. 2009
    ....
  83. pmc Amino-acid-dependent shift in tRNA synthetase editing mechanisms
    Jaya Sarkar
    Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Am Chem Soc 133:18510-3. 2011
    ..In leucyl-tRNA synthetase (LeuRS), editing activities that precede or are subsequent to tRNA charging have been identified...
  84. doi Effects of positive and negative delusional ideation on memory
    Eriko Sugimori
    University of Tokyo, Japan
    Int J Psychol 45:90-101. 2010
    ..qui suggère que les participants avec idéation illusoire étaient de plus en plus susceptibles de dépendre de leurs conditions internes lors du rappel à mesure que le temps passait...
  85. doi LeuRS synthetase: a first-principles investigation of the water-mediated editing reaction
    Mauro Boero
    Institut de Physique et Chimie des Materiaux de Strasbourg, UMR 7504 CNRS UDS, 23 rue du Loess, BP 43, F 67034 Strasbourg, France
    J Phys Chem B 115:12276-86. 2011
    Starting from the crystallographic structure of the Thermus thermophilus leucyl-tRNA (LeuRS) synthethase system and recent theoretical findings, our combined hybrid QM/MM and free energy metadynamics sampling approach shows that in the ..
  86. doi Acculturation and adaptation of immigrant adolescents in Greek urban schools
    Frosso Motti-Stefanidi
    Department of Psychology, School of Philosophy, University of Athens, Greece
    Int J Psychol 43:45-58. 2008
    ..Findings suggest that the acculturation expectations of host country members may be related to immigrants' acculturation orientations...
  87. doi Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
    Ru Juan Liu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Biochem J 440:217-27. 2011
    ..b>LeuRS (leucyl-tRNA synthetase) from Aquifex aeolicus and Giardia lamblia possess unique 20 and 59 amino acid insertions ..
  88. doi Developmental assessment, cultural context, gender, and schooling in Zambia
    Robert Serpell
    Department of Psychology, University of Zambia, Lusaka, Zambia
    Int J Psychol 43:88-96. 2008
    ....
  89. ncbi Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biol Psychiatry 57:525-32. 2005
    ..Analyses of mitochondria-related genes using DNA microarray showed significantly increased LARS2 (mitochondrial leucyl-tRNA synthetase) in the postmortem prefrontal cortices of patients with bipolar disorder ..
  90. doi The role of in-group identification in infra-humanization
    Stephanie Demoulin
    Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Int J Psychol 44:4-11. 2009
    ..The discussion focuses on conditions for reducing infra-humanization and on the relationship between in-group favouritism and out-group derogation...
  91. ncbi [Physical self-concept and teenagers with intellectual disability: age, sex, and weight category effects]
    Jérôme Bégarie
    EA 4206 Conduites addictives, de performance et santé, Universite Montpellier I, Montpellier, France
    Can J Psychiatry 56:179-86. 2011
    ..To study the effects of age, sex, weight, and their interactions on global self-esteem (GSE) and physical self-concept in teenagers with intellectual disability (ID)...
  92. pmc [In Process Citation]
    S Ettalbi
    Service de chirurgie plastique et brûlés, Centre Hospitalier Universitaire Mohamed VI, Marrakech, Maroc
    Ann Burns Fire Disasters 22:64-7. 2009
    ..observations de deux enfants présentant des séquelles de brûlures graves, ayant retenti péjorativement sur leurs scolarités, on a essayé de mettre en évidence quelques facteurs incriminés dans cette tragédie (feu, petites ..
  93. pmc Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus
    R Benarous
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Genetics 119:805-14. 1988
    ..gt11 Neurospora crassa cDNA library and screened the library for the cytoplasmic leucyl-tRNA synthetase (cyto LeuRS) clones using cyto LeuRS specific antibody...
  94. ncbi Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli
    Yong Neng Yao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
    Protein Expr Purif 30:112-6. 2003
    ..The kinetic constants for three substrates: leucine, ATP, and E. coli tRNA1Leu (CAG) in the leucylation reaction are also reported herein...
  95. ncbi Molecular dissection of a critical specificity determinant within the amino acid editing domain of leucyl-tRNA synthetase
    Richard S Mursinna
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    Biochemistry 43:155-65. 2004
    ..Removal of the terminal methyl group of the threonine side chain by replacement with serine yielded a mutant LeuRS that hydrolyzes Leu-tRNA(Leu)...
  96. ncbi Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: two amino acid binding sites in the editing domain
    Keun Woo Lee
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Proteins 54:693-704. 2004
    ..conserved threonine (T252) with an alanine within the editing domain of Escherichia coli leucyl-tRNA synthetase (LeuRS) caused LeuRS to cleave its cognate aminoacylated leucine from tRNA(Leu) (Mursinna et al...
  97. ncbi Groups on the side chain of T252 in Escherichia coli leucyl-tRNA synthetase are important for discrimination of amino acids and cell viability
    Min Gang Xu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Biochem Biophys Res Commun 318:11-6. 2004
    Leucyl-tRNA synthetase (LeuRS) catalyzes the leucylation of tRNA(Leu). To maintain the fidelity of protein biosynthesis, LeuRS also catalyzes the editing reaction...
  98. ncbi Crystallization and preliminary X-ray crystallographic study of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii
    Ryuya Fukunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Acta Crystallogr D Biol Crystallogr 60:1916-8. 2004
    The leucyl-tRNA synthetase (LeuRS) from the archaeon Pyrococcus horikoshii was overexpressed in a C-terminally truncated form in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method using ammonium ..
  99. ncbi An aminoacyl-tRNA synthetase with a defunct editing site
    Stanley W Lue
    Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 44:3010-6. 2005
    ..of these two sites lead to rigorous accuracy in tRNA aminoacylation, and both activities are essential to LeuRS and other aaRSs...
  100. ncbi The origins, early development and status of Bourdieu's concept of 'cultural capital'
    Derek Robbins
    School of Social Sciences, Media and Cultural Studies, University of East London
    Br J Sociol 56:13-30. 2005
    ..in the early 1960s and published by Bourdieu in collaboration with Jean-Claude Passeron in 'Les etudiants et leurs etudes' (1964a) and Les Heritiers (1964b)...
  101. ncbi The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation
    Michael Tukalo
    European Molecular Biology Laboratory, Grenoble Outstation, c o Institut Laue Langevin, 156X, F 38042 Grenoble Cedex 9, France
    Nat Struct Mol Biol 12:923-30. 2005
    Leucyl-tRNA synthetase (LeuRS) has a specific post-transfer editing activity directed against mischarged isoleucine and similar noncognate amino acids...

Research Grants15

  1. tRNA Synthesis Fidelity Mechanisms
    Susan A Martinis; Fiscal Year: 2010
    ..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
  2. tRNA Synthesis Fidelity Mechanisms
    Susan A Martinis; Fiscal Year: 2010
    ..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
  3. tRNA Synthesis Fidelity Mechanisms
    SUSAN MARTINIS; Fiscal Year: 2007
    ..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
  4. Biochemistry of lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2010
    ..The study will also provide further insights into the degree of functional diversity within the aaRS family in general, an emerging group of anti-microbial drug targets. ..
  5. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2007
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
  6. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2006
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
  7. Biochemistry of Class I lysyl-tRNA synthetases
    Michael Ibba; Fiscal Year: 2003
    ..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..