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Genomes and Genes
| LARS2SummaryGene Symbol: LARS2 Description: leucyl-tRNA synthetase 2, mitochondrial Alias: LEURS, leucine tRNA ligase 2, mitochondrial, leucine tRNA ligase 2, mitocondrial, leucine translase Species: human Top Publications
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Publications
Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetesRonghua Li
Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Mol Cell Biol 30:2147-54. 2010..mechanism of the A3243G mutation and whether the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid (cybrid) cells carrying the A3243G mutation corrects the mitochondrial dysfunctions...- Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) geneHyejeong Park
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
RNA 14:2407-16. 2008..This suppression of a tRNA gene mutation by increasing the steady-state levels of its cognate aminoacyl-tRNA synthetase is a model for potential therapies for human pathogenic tRNA mutations... 
A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3H Kiss
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Hum Genet 105:552-9. 1999..The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression...- Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cMA Szeles
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Genes Chromosomes Cancer 20:329-36. 1997..We have defined a common eliminated region of approximately 1.6 cM (designated as CER1) inside the 7 cM CER described earlier. CER1 is flanked distally by D3S1029 and proximally by D3S643... - Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility geneLeen M 't Hart
Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
Diabetes 54:1892-5. 2005..In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes... - How does poverty beget poverty?Linda S Pagani
Ecole de Psychoéducation, Centre de Recherche de l Hôpital Sainte Justine, Universite de Montreal, Montreal, Quebec
Paediatr Child Health 12:693-7. 2007..Puisque leur rendement n'équivaut pas à celui de leurs camarades des classes moyennes, ces enfants sont plus vulnérables à l'échec scolaire et aux troubles de .. - Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientationRyuya Fukunaga
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
J Mol Biol 346:57-71. 2005The editing domains of the closely homologous leucyl, isoleucyl, and valyl-tRNA synthetases (LeuRS, IleRS, and ValRS, respectively) contribute to accurate aminoacylation, by hydrolyzing misformed non-cognate aminoacyl-tRNAs... - Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activityAswini K Betha
Department of Biology and Biochemistry, 369 Science and Research Building II, University of Houston, Houston, Texas 77204 5001, USA
Biochemistry 46:6258-67. 2007Protein synthesis and its fidelity rely upon the aminoacyl-tRNA synthetases. Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthetase (ValRS) have evolved a discrete editing domain called CP1 that .. - A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetasesJennifer L Hsu
Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 S Mathews Ave, Urbana, IL 61801 3732, USA
J Mol Biol 376:482-91. 2008A unique C-terminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation. In one exception, the enzymatic activity of yeast mitochondrial LeuRS is actually impeded by its own C-terminal domain... - A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylationStanley W Lue
Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Biochemistry 46:4466-72. 2007Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high aminoacylation fidelity without a functional editing active site, representing a rare example of a class I aminoacyl-tRNA synthetase (aaRS) that does not proofread .. - Cross-species aminoacylation of tRNA with a long variable arm between Escherichia coli and Saccharomyces cerevisiaeA Soma
Department of Biology, Faculty of Science, Hirosaki University, Hirosaki 036 8561, Japan Biochemistry and Biotechnology, Faculty of
Nucleic Acids Res 26:4374-81. 1998..Both SerRS and LeuRS from E... - Functional association between three archaeal aminoacyl-tRNA synthetasesMette Praetorius-Ibba
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
J Biol Chem 282:3680-7. 2007..aaRSs have also been reported in archaea, including a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter thermautotrophicus that enhances tRNA(Pro) aminoacylation... - Mutational analysis of the antagonist-binding site of the histamine H(1) receptorK Wieland
Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Division of Medicinal Chemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
J Biol Chem 274:29994-30000. 1999..M., Timmerman, H., Leurs, H., Nederkoorn, P. H. J., Smit, M. J., and Donne-Op den Kelder, G. M. (1995) J. Comp. Aid. Mol. Design... - An aminoacyl-tRNA synthetase:elongation factor complex for substrate channeling in archaeal translationCorinne D Hausmann
Department of Microbiology, Ohio State Biochemistry Program, and Ohio State RNA Group, The Ohio State University, Columbus, Ohio 43210 1292, USA
Nucleic Acids Res 35:6094-102. 2007..EF-1alpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM)... - Dynamical networks in tRNA:protein complexesAnurag Sethi
Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 106:6620-5. 2009..pathways in a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex... - Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylationMette Praetorius-Ibba
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
J Biol Chem 280:26099-104. 2005..proteins identified included components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS)... 
Roughness analysis of the skin as a secondary evaluation criterion in addition to visual scoring is sufficient to evaluate ethnic differences in wrinklesT Fujimura
Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Int J Cosmet Sci 31:361-7. 2009..We conclude that roughness analysis of the skin is an important secondary evaluation criterion to visual scoring necessary to evaluate ethnic differences of wrinkles...- An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicingSeung Bae Rho
Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
EMBO J 21:6874-81. 2002Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron and collaborates with the bI4 maturase to aid excision of the group I intron... - A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetaseXiao Long Zhou
State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, People s Republic of China
Biochemistry 48:1340-7. 2009Leucyl-tRNA synthetase (LeuRS) catalyzes the esterification of the tRNA(Leu) isoacceptor with leucine. It contains a large insertion domain, connective peptide 1 (CP1), for amino acid editing... - Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strainPeng Yao
State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
J Biol Chem 283:22591-600. 2008Leucyl-tRNA synthetase (LeuRS) contains an editing domain that discriminates leucine from noncognate amino acids to ensure translational fidelity... - The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editingXiao Long Zhou
State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
J Biol Chem 283:36608-16. 2008Leucyl-tRNA synthetase (LeuRS) has an insertion domain, called connective peptide 2 (CP2), either directly preceding or following the editing domain (CP1 domain), depending on the species... - Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing stepsPeng Yao
State Key Laboratory of Molecular Biology Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, People s Republic of China
Nucleic Acids Res 36:2728-38. 2008..tRNA(Leu) recognition sets and their evolution, the recognition of tRNA(Leu) by the leucyl-tRNA synthetase (LeuRS) from the primitive hyperthermophilic bacterium Aquifex aeolicus was studied by RNA probing and mutagenesis... - [Neuroplasticity: from physiological adaptation to the concept of therapeutic plasticity]Brigitte Onteniente
INSERM, UMR 894, Centre de Recherches en Psychiatrie et Neurosciences, 2ter rue d Alesia, 75014 Paris, France
J Soc Biol 203:107-11. 2009.... - Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetaseXin Chen
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
Nucleic Acids Res 39:235-47. 2011..Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein amino acids and then mischarge tRNA(Leu)... - Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetasesXiao Long Zhou
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, People s Republic of China
Biochem J 429:505-13. 2010b>LeuRS (leucyl-tRNA synthetase) catalyses the esterification of tRNAsLeu with leucine... - Molecular cloning and nucleotide sequence of the gene for Escherichia coli leucyl-tRNA synthetaseM Hartlein
European Molecular Biology Laboratory, Grenoble, France
Nucleic Acids Res 15:10199-210. 1987..coli gene bank DNA. The resulting clones overexpress leucyl-tRNA synthetase (LeuRS) by a factor greater than 50. The DNA sequence of the complete coding regions was determined... - Structural and functional mapping of the archaeal multi-aminoacyl-tRNA synthetase complexCorinne D Hausmann
Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
FEBS Lett 582:2178-82. 2008Methanothermobacter thermautotrophicus contains a multi-aminoacyl-tRNA synthetase complex (MSC) of LysRS, LeuRS and ProRS. Elongation factor (EF) 1A also associates to the MSC, with LeuRS possibly acting as a core protein... - [In Process Citation]Mathieu Molimard
, CHU de Bordeaux, Bordeaux, France
Therapie 64:203-7. 2009..b>Leurs données sont utilisées notamment lors d'une réévaluation anticipée ou lors du renouvellement d'.. - tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetaseMin Tan
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 285:3235-44. 2010..In this work we studied the different editing pathways of class Ia leucyl-tRNA synthetase (LeuRS)... - [Primitive peritonitis: real entity but difficult to diagnose]Rajae Yamou
Service des urgences chirurgicales viscérales, Hopital Ibn Sina, Rabat, Maroc
Pan Afr Med J 12:83. 2012..Elles simulent les péritonites secondaires. C'est pourquoi leur diagnostic ne peut être que peropératoire. Nous rapportons deux cas de péritonites primitives dans le but de discuter leurs aspects diagnostique et thérapeutiques. - Mechanism of the activation step of the aminoacylation reaction: a significant difference between class I and class II synthetasesSindrila Dutta Banik
Department of Chemistry, University of Kalyani, Kalyani, Nadia, West Bengal, 741235, India
J Biomol Struct Dyn 30:701-15. 2012..The class I aaRSs investigated are GluRS, GlnRS, TyrRS, TrpRS, LeuRS, ValRS, IleRS, CysRS, and MetRS and class II aaRSs investigated are HisRS, LysRS, ProRS, AspRS, AsnRS, AlaRS, .. - [[Study of factors related to adherence to antiretroviral therapy among patients followed at HIV/AIDS Unit in the District Hospital of Dschang, Cameroon]]Francois Xavier Mbopi-Keou
Laboratoire National de Santé Hygiène Mobile, Ministere de la Sante Publique, Yaounde, Cameroun et Faculté de Médecine et des Sciences Biomédicales, Universite de Yaounde I, Yaounde, Cameroun
Pan Afr Med J 12:55. 2012..a été évaluée sur la base des déclarations des patients et sur la régularité du renouvellement de leurs ordonnances (observance calculée)... - 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effectsYan Hong Zhang
Shanghai Key Laboratory of Functional Materials Chemistry, and Research Center of Analysis and Test, East China University of Science and Technology, Shanghai 200237, PR China
Fitoterapia 83:1281-5. 2012An aqueous ethanol extract of Artemisia argyi inhibited the aminoacylation activity of LeuRS from Giardia lamblia (GlLeuRS)... - [[Screening for cardiovascular disease among students at the University of Douala and influence of sport and physical activity]]Marielle Epacka Ewane
hôpital général de Douala, Cameroun
Pan Afr Med J 11:77. 2012..CONCLUSION: La présence des MCV et leurs facteurs de risque mis en évidence dans cette étude réalisée en milieu estudiantin camerounais interpelle à .. - Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIleArianna Montanari
Department of Biology and Biotechnology, Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy
RNA 17:1983-96. 2011..On the contrary, both the cognate IleRS and the noncognate LeuRS and ValRS are endowed with suppressing activities toward both mutations... - Leucyl-tRNA synthetase controls TORC1 via the EGO complexGrégory Bonfils
Department of Biology, Division of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
Mol Cell 46:105-10. 2012..We find that the leucyl-tRNA synthetase (LeuRS) Cdc60 interacts with the Rag GTPase Gtr1 of the EGOC in a leucine-dependent manner... - A comparison of fathers' and mothers' contributions in the prediction of academic performance of school-age children in Hong KongVicky C W Tam
Department of Education Studies, Hong Kong Baptist University, Hong Kong
Int J Psychol 44:147-56. 2009..Investigations should also explore other cognitive and noncognitive domains of child outcome, different child age groups, as well as Chinese populations in various geographical regions... - Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutationDaniel Weiss
Department of Otorhinolaryngology, Head and Neck Surgery, University of Muenster, Germany
Mol Carcinog 50:680-8. 2011..genes (TIMP3, CDH1, CDKN2A, DAPK1, transcription factor 21 (TCF21), CD44, MLH1, MGMT, RASSF1, cyclin A1 (CCNA1), LARS2, and CEBPA) was evaluated by methylation-specific polymerase chain reaction in 55 primary HNSCC and 31 controls... - [Optimizing the relational aspects of orthodontics: the foundations of successful cooperation]Edmond Binhas
Institut Binhas, BP 20057, 5 rue de Copenhague, 13742 Vitrolles Cedex, France
Orthod Fr 80:279-90. 2009..As a consequence, there can be repercussions affecting the proper economic growth of the practice. In order to find the most appropriate solutions to this problem, orthodontists must first have a solid understanding of just what it is... - Relationship between tap water hardness, magnesium, and calcium concentration and mortality due to ischemic heart disease or stroke in The NetherlandsLina J Leurs
Maastricht University, GROW School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht, The Netherlands
Environ Health Perspect 118:414-20. 2010..Conflicting results on the relationship between the hardness of drinking water and mortality related to ischemic heart disease (IHD) or stroke have been reported... - A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetaseYan Ling Joy Pang
Department of Biochemistry, University of Illinois, 419 Roger Adams Laboratory, Box B 4, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
Biochemistry 48:8958-64. 2009Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site... - Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalystYohsuke Hagiwara
Center for Computational Sciences, University of Tsukuba, Tennodai 1 1 1, Tsukuba Science City, Ibaraki 305 8577, Japan
J Am Chem Soc 132:2751-8. 2010..We investigated theoretically the mechanism of the editing reaction for a class I enzyme, leucyl-tRNA synthetase (LeuRS), complexed with a misaminoacylated tRNA(Leu), employing ab initio hybrid quantum mechanical/molecular mechanical .. - [Misuse of psychotropic medications in a population of subjects held for custody in the city of Paris]Isabelle Sec
Urgences Médico Judiciaires, Hotel Dieu, faculté Paris Descartes, Universite Paris V, Paris, France
Therapie 64:129-34. 2009..Identify which psychotropic medications are misused and peddled in a population of subjects held for custody in the city of Paris... - La création d'une Section étudiante dans le CIMSagar Dugani
Clin Invest Med 33:E3. 2010..de communication et c'est donc par le biais de la Section étudiante du CIM que les étudiants MD+, leurs superviseurs ainsi que les responsables de programmes MD+ seront en mesure de mettre en valeur des sujets touchant .. - Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editingXiao Long Zhou
State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai 200031, People s Republic of China
Biochem Biophys Res Commun 386:510-5. 2009Leucyl-tRNA synthetase (LeuRS) is responsible for the Leu-tRNA(Leu) synthesis... - Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690Xiao Long Zhou
State Key Laboratory of Molecular Biology and Graduate School of the Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, People s Republic of China
Biochem J 430:325-33. 2010..The CP1 (connective peptide 1) domain of LeuRS (leucyl-tRNA synthetase) contains the editing active site, which is the proven target for the broad-spectrum drug .. - Protein signatures (molecular synapomorphies) that are distinctive characteristics of the major cyanobacterial cladesRadhey S Gupta
Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Int J Syst Evol Microbiol 59:2510-26. 2009..and 1 aa deletion in the RpoC protein); a clade of the low-B/A ecotype Prochlorococcus strains (5 aa deletion in LeuRS and 1 aa insert in the Ffh protein); a clade consisting of the Nostocales species/strains (subclass .. - [[Quality of certificates of assault and battery on adults in Dakar and Diourbel, Senegal]]Mohamed Maniboliot Soumah
Service de médecine légale, Faculte de Medecine, Pharmacie et Odontostomatologie, Université Cheikh Anta Diop UCAD, Dakar, Senegal
Pan Afr Med J 10:59. 2011..de Dakar et de Diourbel, d'apprécier l'évaluation de l'Incapacité Totale de Travail fixée par les médecins et leurs implications judiciaires... - Effects of country size and language similarity on international attitudes: a six-nation studyJan Pieter van Oudenhoven
University of Groningen, The Netherlands
Int J Psychol 45:48-55. 2010..Les nations voisines linguistiquement similaires qui diffèrent en taille sont souvent asymétriques dans leurs relations attitudinales l'une envers l'autre: les citoyens des nations plus petites tendent à voir les nations .. - Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifsG Eriani
Laboratoires de Biochimie, IBMC du CNRS, Strasbourg, France
Nature 347:203-6. 1990..of the 18 known aaRS, only 9 referred to as class I synthetases (GlnRS, TyrRS, MetRS, GluRS, ArgRS, ValRS, IleRS, LeuRS, TrpRS), display two short common consensus sequences ('HIGH' and 'KMSKS') which indicate, as observed in three .. - Human and peoples' rights: social representations among Cameroonian studentsAnna Maija Pirttilä-Backman
University of Helsinki, Helsinki, Finland
Int J Psychol 44:459-67. 2009..Men may feel frustrated in the context of political liberalization because the freedoms are more theoretical than fulfilled; the economic crises and cultural changes have hindered their economic domination and their prerogatives... - Acculturation and its determinants among adult immigrants in FranceHisham Motkal Abu-Rayya
School of Psychology, University of Sydney, Sydney, Australia
Int J Psychol 44:195-203. 2009..Findings revealed also that those identifying with their home country/ethnic group recorded relatively higher degrees of maladjustment than those asserting a French identification... - The willingness to relocate to another country: the impact of cultural similarity, destination safety, and financial incentiveMichael R Wagner
Department of Organization and Leadership, Teachers College, Columbia University, New York, NY 10027, USA
Int J Psychol 44:257-65. 2009..Against expectations, there was no interaction between financial incentives and safety. Destination safety perceptions were relatively strong determinants of willingness to relocate... - Long-term immigrant adaptation: eight-year follow-up study among immigrants from Russia and Estonia living in FinlandInga Jasinskaja-Lahti
Department of Social Psychology, University of Helsinki, Helsinki, Finland
Int J Psychol 43:6-18. 2008..En huit ans, les répondants avaient amélioré leurs habiletés en finlandais sur le marché de travail... - [[Assessment of patients' satisfaction in obstetrics and gynecology ward in Sousse, Tunisia]]Iheb Bougmiza
Département de Médecine Communautaire Faculté de Médecine Ibn El Jazzar, Université de Sousse, Tunisie
Pan Afr Med J 8:44. 2011..de qualité moindre ou de qualité similaire, et celles qui avaient l'intention de recommander l'hôpital à leurs proches... - A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activityMin Tan
State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
Biochem J 443:477-84. 2012..For LeuRS (leucyl-tRNA synthetase), the CP1 (connective peptide 1) domain is the editing domain responsible for hydrolysing .. - Parent-child conflict and psychological maladjustment: a mediational analysis with reciprocal filial belief and perceived threatKuang Hui Yeh
Academia Sinica, Taipei, Taiwan
Int J Psychol 45:131-9. 2010..le conflit parent-enfant nuit aux peceptions des adolescents de leur relation avec les parents ainsi que de leurs auto-perceptions dans le cadre de leur évaluation cognitive... - Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editingVrajesh A Karkhanis
Department of Biochemistry, University of Illinois at Urbana Champaign, 600 S Mathews Ave, 419 Roger Adams Laboratory, Box B 4, Urbana, Illinois 61801 3732, USA
J Bacteriol 189:8765-8. 2007Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation... - The importance of values in predicting Turkish youth's opinions about the European Union in light of the Copenhagen Political CriteriaM Ersin Kuşdil
Uludag University, Bursa, Turkey
Int J Psychol 43:988-96. 2008..As for nationalism, the results showed that this variable was related negatively to reduction of the military influence, improvement of human rights and liberties, improvement of minority rights; and positively to scepticism... - Sex differences in psychological effects of exerciseF Hülya Aşçı
Baskent University, Sport Sciences Department, Ankara, Turkiye
Int J Psychol 44:313-20. 2009..Exerciser males improved their personal self and physical self scores more than female exercisers and male and female nonexercisers throughout the 10-week period (p<.05)... - Self- and other-estimates of multiple abilities in Britain and Turkey: a cross-cultural comparison of subjective ratings of intelligenceAdrian Furnham
Department of Psychology, University College London, London, UK
Int J Psychol 44:434-42. 2009..Results are discussed in terms of the growing literature in the field... - The adaptation of Chinese adolescents in two societies: a comparison of Chinese adolescents in Hong Kong and AustraliaCynthia Leung
Department of Educational Psychology, Counselling and Learning Needs, The Hong Kong Institute of Education, Hong Kong
Int J Psychol 44:170-8. 2009..Migrant adolescents reported better psychological and sociocultural adaptation than their nonmigrant counterparts. The results were discussed in relation to the social and educational systems of the two societies... - Amino-acid-dependent shift in tRNA synthetase editing mechanismsJaya Sarkar
Department of Biochemistry, University of Illinois at Urbana Champaign, 419 Roger Adams Laboratory, Box B 4, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
J Am Chem Soc 133:18510-3. 2011..In leucyl-tRNA synthetase (LeuRS), editing activities that precede or are subsequent to tRNA charging have been identified... - Individual differences in coping with criticism of one's physical appearance among Taiwanese studentsLuo Lu
Department of Business Administration, National Taiwan University, Taipei, Taiwan, Republic of China
Int J Psychol 44:274-81. 2009..Possible influences of the Chinese collectivist culture on people's responses to criticism were also delineated, such as valuing interpersonal harmony and face-work in social situations... - The relationship between three types of aggression and peer relations in elementary school childrenKatsuyuki Yamasaki
Department of Human Development, Naruto University of Education, Tokushima, Japan
Int J Psychol 44:179-86. 2009..The implications of these findings with respect to internalizing and externalizing problem behaviours for aggressive children are discussed... - Effects of positive and negative delusional ideation on memoryEriko Sugimori
University of Tokyo, Japan
Int J Psychol 45:90-101. 2010..qui suggère que les participants avec idéation illusoire étaient de plus en plus susceptibles de dépendre de leurs conditions internes lors du rappel à mesure que le temps passait... - Effects of received and mobilized support on recipients' and providers' self-efficacy beliefs: a 1-year follow-up study with patients receiving radical prostatectomy and their spousesNina Knoll
Charite Universitatsmedizin Berlin, Germany
Int J Psychol 44:129-37. 2009.... - [In Process Citation]S Ettalbi
Service de chirurgie plastique et brûlés, Centre Hospitalier Universitaire Mohamed VI, Marrakech, Maroc
Ann Burns Fire Disasters 22:64-7. 2009..observations de deux enfants présentant des séquelles de brûlures graves, ayant retenti péjorativement sur leurs scolarités, on a essayé de mettre en évidence quelques facteurs incriminés dans cette tragédie (feu, petites .. - Personal investment, culture and learning: insights into school achievement across Anglo, Aboriginal, Asian and Lebanese students in AustraliaDennis M McInerney
Centre for Research in Pedagogy and Practice, National Institute of Education, Nanyang Technological University, Singapore
Int J Psychol 43:870-9. 2008..Across cultural groups, students' mastery goal and sense of purpose were consistently found to be significant predictors of their intention for further education, positive affect for schooling, and valuing of schooling... - Acculturation and adaptation of immigrant adolescents in Greek urban schoolsFrosso Motti-Stefanidi
Department of Psychology, School of Philosophy, University of Athens, Greece
Int J Psychol 43:45-58. 2008..Findings suggest that the acculturation expectations of host country members may be related to immigrants' acculturation orientations... - LeuRS synthetase: a first-principles investigation of the water-mediated editing reactionMauro Boero
Institut de Physique et Chimie des Materiaux de Strasbourg, UMR 7504 CNRS UDS, 23 rue du Loess, BP 43, F 67034 Strasbourg, France
J Phys Chem B 115:12276-86. 2011Starting from the crystallographic structure of the Thermus thermophilus leucyl-tRNA (LeuRS) synthethase system and recent theoretical findings, our combined hybrid QM/MM and free energy metadynamics sampling approach shows that in the .. - Developmental assessment, cultural context, gender, and schooling in ZambiaRobert Serpell
Department of Psychology, University of Zambia, Lusaka, Zambia
Int J Psychol 43:88-96. 2008.... - Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetaseRu Juan Liu
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
Biochem J 440:217-27. 2011..b>LeuRS (leucyl-tRNA synthetase) from Aquifex aeolicus and Giardia lamblia possess unique 20 and 59 amino acid insertions .. - The role of in-group identification in infra-humanizationStephanie Demoulin
Universite Catholique de Louvain, Louvain la Neuve, Belgium
Int J Psychol 44:4-11. 2009..The discussion focuses on conditions for reducing infra-humanization and on the relationship between in-group favouritism and out-group derogation... - Confidence judgments in real classroom settings: monitoring performance in different types of testsMoisés Kirk de Carvalho Filho
Graduate School of Education, Kyoto University, Kyoto, Japan
Int J Psychol 44:93-108. 2009..In addition, based on the results obtained, specific suggestions on how to increase the metacognitive awareness of university students through instruction and on how to improve their academic assessment are provided... - [Physical self-concept and teenagers with intellectual disability: age, sex, and weight category effects]Jérôme Bégarie
EA 4206 Conduites addictives, de performance et santé, Universite Montpellier I, Montpellier, France
Can J Psychiatry 56:179-86. 2011..To study the effects of age, sex, weight, and their interactions on global self-esteem (GSE) and physical self-concept in teenagers with intellectual disability (ID)... - Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agentsDazhong Ding
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
J Med Chem 54:1276-87. 2011..brucei parasite growth inhibition activity. This is the first time that TbLeuRS inhibitors are reported, and this study suggests that leucyl-tRNA synthetase (LeuRS) could be a potential target for antiparasitic drug development. - Contextualized self: when the self runs into social dilemmasChang Jiang Liu
Chinese Academy of Sciences, Beijing, China, and Shenyang Normal University, Shenyang, China
Int J Psychol 44:451-8. 2009..The results demonstrate that the self can be contextualized and embedded in the social contexts and symbolic systems within which people live... - Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locusR Benarous
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Genetics 119:805-14. 1988..gt11 Neurospora crassa cDNA library and screened the library for the cytoplasmic leucyl-tRNA synthetase (cyto LeuRS) clones using cyto LeuRS specific antibody... - Molecular dissection of a critical specificity determinant within the amino acid editing domain of leucyl-tRNA synthetaseRichard S Mursinna
Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
Biochemistry 43:155-65. 2004..Removal of the terminal methyl group of the threonine side chain by replacement with serine yielded a mutant LeuRS that hydrolyzes Leu-tRNA(Leu)... - Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: two amino acid binding sites in the editing domainKeun Woo Lee
Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
Proteins 54:693-704. 2004..conserved threonine (T252) with an alanine within the editing domain of Escherichia coli leucyl-tRNA synthetase (LeuRS) caused LeuRS to cleave its cognate aminoacylated leucine from tRNA(Leu) (Mursinna et al... - Groups on the side chain of T252 in Escherichia coli leucyl-tRNA synthetase are important for discrimination of amino acids and cell viabilityMin Gang Xu
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
Biochem Biophys Res Commun 318:11-6. 2004Leucyl-tRNA synthetase (LeuRS) catalyzes the leucylation of tRNA(Leu). To maintain the fidelity of protein biosynthesis, LeuRS also catalyzes the editing reaction... - Crystallization and preliminary X-ray crystallographic study of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshiiRyuya Fukunaga
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
Acta Crystallogr D Biol Crystallogr 60:1916-8. 2004The leucyl-tRNA synthetase (LeuRS) from the archaeon Pyrococcus horikoshii was overexpressed in a C-terminally truncated form in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method using ammonium .. - An aminoacyl-tRNA synthetase with a defunct editing siteStanley W Lue
Eugene F Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Biochemistry 44:3010-6. 2005..of these two sites lead to rigorous accuracy in tRNA aminoacylation, and both activities are essential to LeuRS and other aaRSs... - Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophreniaKae Munakata
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Biol Psychiatry 57:525-32. 2005..Analyses of mitochondria-related genes using DNA microarray showed significantly increased LARS2 (mitochondrial leucyl-tRNA synthetase) in the postmortem prefrontal cortices of patients with bipolar disorder .. - The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformationMichael Tukalo
European Molecular Biology Laboratory, Grenoble Outstation, c o Institut Laue Langevin, 156X, F 38042 Grenoble Cedex 9, France
Nat Struct Mol Biol 12:923-30. 2005Leucyl-tRNA synthetase (LeuRS) has a specific post-transfer editing activity directed against mischarged isoleucine and similar noncognate amino acids... - Expression, purification, and characterization of a new heterotetramer structure of leucyl-tRNA synthetase from Aquifex aeolicus in Escherichia coliNatacha Olieric
, UMR7104, , , 1 rue Laurent Fries 67404 Illkirch, France
Protein Expr Purif 47:1-9. 2006..Aquifex aeolicus leucyl-tRNA synthetase (LeuRS) is composed of a separated catalytic site and tRNA anticodon-binding site, which would represent one of the .. - Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coliYong Neng Yao
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
Protein Expr Purif 30:112-6. 2003..The kinetic constants for three substrates: leucine, ATP, and E. coli tRNA1Leu (CAG) in the leucylation reaction are also reported herein... - Enzymes assembled from Aquifex aeolicus and Escherichia coli leucyl-tRNA synthetasesMing Wei Zhao
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Biochemistry 42:7694-700. 2003Aquifex aeolicus alphabeta-LeuRS is the only known heterodimeric LeuRS, while Escherichia coli LeuRS is a canonical monomeric enzyme. By using the genes encoding A. aeolicus and E... - Tertiary structure base pairs between D- and TpsiC-loops of Escherichia coli tRNA(Leu) play important roles in both aminoacylation and editingXing Du
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Nucleic Acids Res 31:2865-72. 2003..of tRNA(Leu) tertiary structure in the aminoacylation and editing reactions catalyzed by leucyl-tRNA synthetase (LeuRS)... - A structure-based multiple sequence alignment of all class I aminoacyl-tRNA synthetasesC Landes
Centre de Genetique Moleculaire, Universite P and M Curie, Gif sur Yvette, France
Biochimie 77:194-203. 1995..The alignments also indicate that the class I synthetases may be partitioned into two subgroups: a) MetRS, IleRS, LeuRS, ValRS, CysRS and ArgRS; b) GlnRS, GluRS, TyrRS and TrpRS. - Expression and characterization of the human mitochondrial leucyl-tRNA synthetaseJ M Bullard
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599 3290, USA
Biochim Biophys Acta 1490:245-58. 2000..motifs of class I aminoacyl-tRNA synthetases and regions of high homology to other mitochondrial and bacterial LeuRS proteins. The mature form of this protein has been cloned and expressed in Escherichia coli... - CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing functionJ F Chen
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Academia Sinica, 320 Yue Yang Road, Shanghai 200031, China
Biochemistry 39:6726-31. 2000..In this study, we created LeuRS-B, a mutant leucyl-tRNA synthetase from Escherichia coli with a duplication of the peptide fragment from Met328 to .. - Regulation of the nuclear genes encoding the cytoplasmic and mitochondrial leucyl-tRNA synthetases of Neurospora crassaC M Chow
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Mol Cell Biol 9:4645-52. 1989We show that the nuclear genes for the cytoplasmic and mitochondrial leucyl-tRNA synthetase (LeuRS) of Neurospora crassa are distinct in their encoded proteins, codon usage, mRNA levels, and regulation. The 4... - Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivoYi Tang
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Biochemistry 41:10635-45. 2002..Leucyl-tRNA synthetase (LeuRS) relies on its editing function to correct misaminoacylation of tRNA(Leu) by isoleucine and methionine... - Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3Hajnalka Kiss
Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Nobelsvag 16, S 171 77 Stockholm, Sweden
Mamm Genome 13:646-55. 2002..We also recognized a large number of conserved elements that were neither exons, CpG islands, nor repeats. We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3s1, Fyco1, Tmem7, and Lrrc2)... - The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylationHyejeong Park
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 South 10th Street, BLSB 308, Philadelphia, Pennsylvania 19107, USA
Biochemistry 42:958-64. 2003..These results also suggest that the A3243G and T3271C mutations may have distinct mechanisms of pathogenesis... - E292 is important for the aminoacylation activity of Escherichia coli leucyl-tRNA synthetaseXing Du
State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Protein Chem 22:71-6. 2003Escherichia coli leucyl-tRNA synthetase (LeuRS) has a large connecting polypeptide (CP1) inserted into its active site. It was demonstrated that the peptide bond between E292-A293 was crucial for the aminoacylation activity of E... - Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discriminationYunqing Liu
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Biochem J 394:399-407. 2006..b>LeuRS (leucyl-tRNA synthetase) can link not only the cognate leucine but also the nearly cognate residues Ile and Met to .. - Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetaseVincent Cura
Département de Biologie et Génomique Structurales, UMR 7104, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:899-901. 2005The editing or hydrolytic CP1 domain of leucyl-tRNA synthetase (LeuRS) hydrolyses several misactivated amino acids... - Identification of the nucleophilic factors and the productive complex for the editing reaction by leucyl-tRNA synthetaseYohsuke Hagiwara
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
FEBS Lett 583:1901-8. 2009..In this report, based on our previously-modelled structure of leucyl-tRNA synthetase (LeuRS) complexed with valyl-tRNA(Leu), further structural modelling has been performed along with molecular dynamics ..
Research Grants
- tRNA Synthesis Fidelity MechanismsSusan A Martinis; Fiscal Year: 2010..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
- tRNA Synthesis Fidelity MechanismsSusan A Martinis; Fiscal Year: 2010..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
- tRNA Synthesis Fidelity MechanismsSUSAN MARTINIS; Fiscal Year: 2007..E. coli leucyl-tRNA synthetase (LeuRS) is unique because it edits exclusively by a post-transfer mechanism...
- Biochemistry of lysyl-tRNA synthetasesMichael Ibba; Fiscal Year: 2010..The study will also provide further insights into the degree of functional diversity within the aaRS family in general, an emerging group of anti-microbial drug targets. ..
- Biochemistry of Class I lysyl-tRNA synthetasesMichael Ibba; Fiscal Year: 2007..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
- Biochemistry of Class I lysyl-tRNA synthetasesMichael Ibba; Fiscal Year: 2006..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..
- Biochemistry of Class I lysyl-tRNA synthetasesMichael Ibba; Fiscal Year: 2003..This, in turn, will provide a framework for developing therapeutics specifically targeted against the class I lysyl-tRNA synthetase. ..