LARS

Summary

Gene Symbol: LARS
Description: leucyl-tRNA synthetase
Alias: HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, leucine--tRNA ligase, cytoplasmic, cytoplasmic leucyl-tRNA synthetase, cytosolic leucyl-tRNA synthetase, leucine tRNA ligase 1, cytoplasmic, leucine translase, proliferation-inducing gene 44
Species: human
Products:     LARS

Top Publications

  1. Rho S, Kim M, Lee J, Seol W, Motegi H, Kim S, et al. Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. Proc Natl Acad Sci U S A. 1999;96:4488-93 pubmed
    ..Thus, small peptide appendices seem to link together different synthetases into a complex. In addition, five interacting pairs that had not been detected previously were suggested from the observed peptide-dependent complexes. ..
  2. Shin S, Kim H, Jung S, Xu H, Jeong Y, Chung Y. Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. Exp Mol Med. 2008;40:229-36 pubmed
    ..Of the DEGs, over-expression of leucyl-tRNA synthetase 1 (LARS1) was prominent and this up-regulation was confirmed by immunoblotting and real-time quantitative RT-PCR analysis...
  3. Seiradake E, Mao W, Hernandez V, Baker S, Plattner J, Alley M, et al. Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles. J Mol Biol. 2009;390:196-207 pubmed publisher
    Leucyl-tRNA synthetase (LeuRS) specifically links leucine to the 3' end of tRNA(leu) isoacceptors...
  4. Ling C, Yao Y, Zheng Y, Wei H, Wang L, Wu X, et al. The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. J Biol Chem. 2005;280:34755-63 pubmed
    ..Our results also indicate that the two molecules interact with each other only through their appended domains. ..
  5. Ma Y, Batistel F, Xu T, Han L, Bucktrout R, Liang Y, et al. Phosphorylation of AKT serine/threonine kinase and abundance of milk protein synthesis gene networks in mammary tissue in response to supply of methionine in periparturient Holstein cows. J Dairy Sci. 2019;102:4264-4274 pubmed publisher
    ..abundance of high-affinity cationic (SLC7A1) and sodium-coupled AA transporters (SLC38A1, SLC38A2); leucyl-tRNA (LARS), valyl-tRNA (VARS), and isoleucyl-tRNA synthetases (IARS); glucose transport solute carrier family 2 member 3 (..
  6. Peroutka C, Salas J, Britton J, Bishop J, Kratz L, Gilmore M, et al. Severe Neonatal Manifestations of Infantile Liver Failure Syndrome Type 1 Caused by Cytosolic Leucine-tRNA Synthetase Deficiency. JIMD Rep. 2019;45:71-76 pubmed publisher
    Deleterious mutations in cytosolic leucine-tRNA synthetase (LARS) cause infantile liver failure syndrome, type 1 (ILFS1), a recently recognized, rare autosomal recessive disorder (OMIM151350)...
  7. Matsuo M, Hiramatsu M, Singh M, Sasaki T, Hishinuma T, Yamamoto N, et al. Genetic and Transcriptomic Analyses of Ciprofloxacin-Tolerant Staphylococcus aureus Isolated by the Replica Plating Tolerance Isolation System (REPTIS). Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..in the stress-mediating gene, relA Additionally, two strains carried the same point mutation in the leuS gene, encoding leucyl-tRNA synthetase...
  8. Kumagai Y, Gilmour S, Ota E, Momose Y, Onishi T, Bilano V, et al. Estimating the burden of foodborne diseases in Japan. Bull World Health Organ. 2015;93:540-549C pubmed publisher
    ..La charge des maladies d'origine alimentaire au Japon est principalement liée à leurs complications secondaires...
  9. Rainville J, Bono J, Laxer E, Kim D, Lavelle J, Indahl A, et al. Comparison of the history and physical examination for hip osteoarthritis and lumbar spinal stenosis. Spine J. 2019;: pubmed publisher
    ..Positive LRs were compared with surveyed physicians' values for each test...

More Information

Publications139 found, 100 shown here

  1. Prabhu N, Yun H. Comparative analysis of polyspecificity of the endogenous tRNA synthetase of different expression host towards photocrosslinking amino acids using an in silico approach. J Mol Graph Model. 2017;75:375-382 pubmed publisher
    ..With this in mind, we studied in silico analysis of polyspecificity of four endogenous tRNA synthetases (LeuRS, IleRS, MetRS, and LysRS) from six different species such as Escherichia coli, Pseudomonas fluorescens, ..
  2. Baron A, Kako S, Feser W, Malinowski H, Merrick D, Garg K, et al. Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer. J Thorac Oncol. 2017;12:1512-1523 pubmed publisher
    ..Sensitivity, specificity, and positive and negative likelihood ratios (LRs) (with 95% confidence intervals [CIs]) were estimated for each cohort...
  3. Harland E, Griffith J, Lu H, Erickson T, Magsino K. Health behaviours associated with indoor tanning based on the 2012/13 Manitoba Youth Health Survey. Health Promot Chronic Dis Prev Can. 2016;36:149-62 pubmed
    ..tests pour déterminer toute colinéarité potentielle et elles ont été regroupées en fonction de la force de leurs associations...
  4. Zeng N, Prodhan U, D Souza R, Ramzan F, Mitchell S, Sharma P, et al. Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men. J Nutr Health Aging. 2019;23:354-363 pubmed publisher
    ..downregulation of LAT1 did not affect the expression of AA sensors and mediators, including leucyl tRNA synthetase (LRS), cytosolic arginine sensor for mTORC1 (CASTOR1), Sestrin2 and Rag proteins...
  5. Manhas R, Tandon S, Sen S, Tiwari N, Munde M, Madhubala R. Leishmania donovani Parasites Are Inhibited by the Benzoxaborole AN2690 Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..the present study was to obtain essentiality data for Leishmania donovani leucyl-tRNA synthetase (LdLRS) by gene replacement...
  6. Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, et al. Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase. J Mol Biol. 2018;430:1-16 pubmed publisher
    ..To assess the origin of specificity of Escherichia coli leucyl-tRNA synthetase (LeuRS) against the cognate aminoacylation product in editing, we followed binding and catalysis independently using ..
  7. Fuchs S, Schene I, Kok G, Jansen J, Nikkels P, van Gassen K, et al. Aminoacyl-tRNA synthetase deficiencies in search of common themes. Genet Med. 2018;: pubmed publisher
    ..In literature, we identified 107 patients with AARS, DARS, GARS, HARS, IARS, KARS, LARS, MARS, RARS, SARS, VARS, YARS, and QARS deficiencies...
  8. Akolekar R, Ciobanu A, Zingler E, Syngelaki A, Nicolaides K. Routine assessment of cerebroplacental ratio at 35-37 weeks' gestation in the prediction of adverse perinatal outcome. Am J Obstet Gynecol. 2019;: pubmed publisher
  9. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, et al. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016;60:4886-95 pubmed publisher
    ..falciparum leucyl-tRNA synthetase (LeuRS; PF3D7_0622800) and in another gene (PF3D7_1218100), which encodes a protein of unknown function...
  10. Lin W, Zheng Q, Guo L, Cheng Y, Song Y. [Clinical feature and molecular diagnostic analysis of the first non-caucasian child with infantile liver failure syndrome type 1]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:913-920 pubmed
    Infantile liver failure syndrome type 1 (ILFS1) is a Mendelian disease due to biallelic mutations in the cytoplasmic leucyl-tRNA synthetase gene (LARS)...
  11. McGovern G, Martin S, Jeffrey M, Bellworthy S, Spiropoulos J, Green R, et al. Influence of breed and genotype on the onset and distribution of infectivity and disease-associated prion protein in sheep following oral infection with the bovine spongiform encephalopathy agent. J Comp Pathol. 2015;152:28-40 pubmed publisher
    ..In MARQ/MARQ sheep of both breeds, initial PrP(d) accumulation was identified in lymphoreticular system (LRS) tissues followed by the central nervous system (CNS) and enteric nervous system (ENS) and finally by the autonomic ..
  12. Dang Y, Liu T, Mei X, Meng X, Gou X, Deng B, et al. Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury. J Surg Res. 2017;220:363-371 pubmed publisher
    ..and the others were subjected to severe hemorrhagic shock and then treated with lactated Ringer's solution (LRS), hydrogen-rich solution, hyperoxygenated solution, or HHOS...
  13. Yang S, Yang Y, Yu P, Yang J, Jiang X, Villar V, et al. Dopamine D1 and D5 receptors differentially regulate oxidative stress through paraoxonase 2 in kidney cells. Free Radic Res. 2015;49:397-410 pubmed publisher
    ..Fenoldopam increased PON2 protein in both lipid rafts (LRs) and non-LRs in HEK-hD1R cells, but only in non-LRs in HEK-hD5R and hRPT cells...
  14. Ye Q, Ji Q, Yan W, Yang F, Wang E. Acetylation of lysine ?-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. J Biol Chem. 2017;292:10709-10722 pubmed publisher
    ..In this present study, leucyl-tRNA synthetase and arginyl-tRNA synthetase from Escherichia coli (EcLeuRS and EcArgRS) were overexpressed and purified and found to be acetylated on Lys residues by MS...
  15. Lee K, Wang L, Chiang T, Wang Y. Effects of Electrodes on the Switching Behavior of Strontium Titanate Nickelate Resistive Random Access Memory. Materials (Basel). 2015;8:7191-7198 pubmed publisher
    ..a high resistance ratio of >10? between the high-resistance state (HRS) and the low-resistance state (LRS), as well as a retention ability of >10? s...
  16. Ji Q, Fang Z, Ye Q, Chi C, Wang E. Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. Nucleic Acids Res. 2017;45:7367-7381 pubmed publisher
    ..Nva could be misincorporated into the proteome of the LeuRS editing-deficient yeast strain (D419A/Sc?leuS), potentially resulting in dysfunctional protein folding and growth ..
  17. Lowe A, Broadley K, Nials A, Ford W, Kidd E. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. J Pharmacol Toxicol Methods. 2015;72:85-93 pubmed publisher
    Inhalation of antigen in atopic asthma induces early (EAR) and late asthmatic responses (LARs), inflammatory cell infiltration and airways hyperresponsiveness (AHR)...
  18. Colin I, Colin H, Dufour I, Gielen C, Many M, Saey J, et al. Extrapancreatic effects of incretin hormones: evidence for weight-independent changes in morphological aspects and oxidative status in insulin-sensitive organs of the obese nondiabetic Zucker rat (ZFR). Physiol Rep. 2016;4: pubmed publisher
    ..Ex-4-treated ZFRs were compared to vehicle (saline)-treated ZFRs and vehicle- and Ex-4-treated lean rats (LRs). Blood glucose levels were measured at days 0, 9, and 10. Ingested food and animal weight were recorded daily...
  19. Taylor J, Rodenburg M, Snider T. Comparison of a commercially available oral nutritional supplement and intravenous fluid therapy for dehydration in dairy calves. J Dairy Sci. 2017;100:4839-4846 pubmed publisher
    ..St. Joseph, MO) and i.v. lactated Ringer's solution (LRS) in rehydrating, preventing acidemia, and correcting electrolyte imbalances in an experimental model for calf ..
  20. Shah S, Bachur R, Simel D, Neuman M. Does This Child Have Pneumonia?: The Rational Clinical Examination Systematic Review. JAMA. 2017;318:462-471 pubmed publisher
    ..A third author resolved disputes. Likelihood ratios (LRs), sensitivity, and specificity were calculated for individual symptoms and physical examination findings for the ..
  21. Palencia A, Li X, Bu W, Choi W, Ding C, Easom E, et al. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016;60:6271-80 pubmed publisher
    ..tRNA-trapping (OBORT) mechanism, which was first developed to target fungal cytoplasmic leucyl-tRNA synthetase (LeuRS), to M. tuberculosis LeuRS...
  22. Kim C, Hur J, Eo S, Park S, Lee J. Generation of Salmonella ghost cells expressing fimbrial antigens of enterotoxigenic Escherichia coli and evaluation of their antigenicity in a murine model. Can J Vet Res. 2016;80:40-8 pubmed
    ..les fimbriae K88ab, K88ac, K99, et FasA d’Escherichia coli entérotoxigénique (ETEC) dans leurs enveloppes ont été construits...
  23. Ardanaz N, Vazquez F, Romero A, Remacha A, Barrachina L, Sanz A, et al. Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints. BMC Vet Res. 2016;12:65 pubmed publisher
    ..All contralateral joints were injected with Lactated Ringer's Solution (LRS) as the control vehicle...
  24. Bandyopadhyay C, Veettil M, Dutta S, Chandran B. p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cells. J Virol. 2014;88:13858-78 pubmed publisher
    ..p130Cas and Crk were associated with KSHV, LRs, EphA2, and CIB1 early during infection...
  25. Lei H, Zhou X, Ruan Z, Sun W, Eriani G, Wang E. Calpain Cleaves Most Components in the Multiple Aminoacyl-tRNA Synthetase Complex and Affects Their Functions. J Biol Chem. 2015;290:26314-27 pubmed publisher
    ..A yeast two-hybrid screen for proteins interacting with LeuRS, a representative MSC member, identified calpain 2, a calcium-activated neutral cysteine protease...
  26. De Chatterjee A, Mendez T, Roychowdhury S, Das S. The assembly of GM1 glycolipid- and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation. Infect Immun. 2015;83:2030-42 pubmed publisher
    ..Since the GM1 ganglioside is a major constituent of mammalian lipid rafts (LRs) and known to react with cholera toxin B (CTXB), we used Alexa Fluor-conjugated CTXB and GM1 antibodies to detect ..
  27. Chen X, Zhang M, Wang M, Tan G, Zhang M, Hou Y, et al. The effects of mepiquat chloride on the lateral root initiation of cotton seedlings are associated with auxin and auxin-conjugate homeostasis. BMC Plant Biol. 2018;18:361 pubmed publisher
    ..To increase root growth, cotton seeds were treated with MC to increase the number of lateral root (LRs) and improve drought resistance...
  28. Kobayashi N, Oshiki M, Ito T, Segawa T, Hatamoto M, Kato T, et al. Removal of human pathogenic viruses in a down-flow hanging sponge (DHS) reactor treating municipal wastewater and health risks associated with utilization of the effluent for agricultural irrigation. Water Res. 2017;110:389-398 pubmed publisher
    ..norovirus GII that would be required for the use of DHS effluent for agricultural irrigation, and it was found that LRs of 2.6 and 3...
  29. Knirel Y, Guo X, Senchenkova S, Perepelov A, Liu B, Shashkov A. Structures and gene clusters of the O-specific polysaccharides of the lipopolysaccharides of Escherichia coli O69 and O146 containing glycolactilic acids: ether conjugates of D-GlcNAc and D-Glc with (R)- and (S)-lactic acid. Glycoconj J. 2017;34:71-84 pubmed publisher
    ..predicted enolpyruvate reductases of the biosynthesis pathway of glycolactilic acids, LarR and LarS, which catalyze formation of conjugates with (R)- or (S)-lactic acid, respectively, are distinguished by sequence ..
  30. Brünisholz H, Schwarzwald C, Bettschart Wolfensberger R, Ringer S. Effects of 10% hydroxyethyl starch (HES 200/0.5) solution in intraoperative fluid therapy management of horses undergoing elective surgical procedures. Vet J. 2015;206:398-403 pubmed publisher
    ..Horses of the NH group received an equal amount of lactated Ringer's solution (LRS)...
  31. Gao S, Wolanyk N, Chen Y, Jia S, Hessner M, Wang X. Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes. BMC Med Genomics. 2017;10:7 pubmed publisher
    ..onset T1D patients (RO-T1D), and healthy siblings of probands that possess high (HRS, High Risk Sibling) or low (LRS, Low Risk Sibling) risk HLA haplotypes...
  32. Freitag M, Radtke J, Afshar Oromieh A, Roethke M, Hadaschik B, Gleave M, et al. Local recurrence of prostate cancer after radical prostatectomy is at risk to be missed in 68Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI integrated in simultaneous PET/MRI. Eur J Nucl Med Mol Imaging. 2017;44:776-787 pubmed publisher
    ..The size of LRs did not affect PET-detectability (p?=?0.84), mean size was 1.7?±?0.69 cm long axis, 1.2?±?0.46 cm short-axis...
  33. Schreurs L, Janssens A, Groen H, Fockens P, van Dullemen H, van Berge Henegouwen M, et al. Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer?. Ann Surg Oncol. 2016;23:1021-1028 pubmed
    ..Initial EUS results were not significantly related to the LRs of initial CT and FDG-PET results...
  34. Friedman S, Farfel M, Maslow C, Cone J, Brackbill R, Stellman S. Comorbid persistent lower respiratory symptoms and posttraumatic stress disorder 5-6 years post-9/11 in responders enrolled in the World Trade Center Health Registry. Am J Ind Med. 2013;56:1251-61 pubmed publisher
    Co-occurrence of lower respiratory symptoms (LRS) and posttraumatic stress disorder (PTSD) has been increasingly recognized among responders and survivors of the World Trade Center (WTC) disaster...
  35. Aydin C, Oztan O, Isgor C. Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype. Pharmacol Biochem Behav. 2014;125:48-54 pubmed publisher
    ..Previous reports from our laboratory show that HRs, but not LRs, develop locomotor sensitization to a low dose nicotine challenge and exhibit increased social anxiety-like ..
  36. Yeo H, Abelson J, Mao J, Cheerharan M, Milsom J, Sedrakyan A. Minimally invasive surgery and sphincter preservation in rectal cancer. J Surg Res. 2016;202:299-307 pubmed publisher
    ..0%) patients underwent LAR, and 15,288 (38.0%) underwent APR from 2009 to 2011. A total of 22,310 (89.2%) LARs were open and 2689 (10.8%) MIS. A total of 11,600 (75.9%) APRs were open and 3688 (24.1%) MIS...
  37. Schoenthaler M, Hein S, Seitz C, Turk C, Danuser H, Vach W, et al. The stone surgeon in the mirror: how are German-speaking urologists treating large renal stones today?. World J Urol. 2018;36:467-473 pubmed publisher
    To elucidate the current treatment strategies of LRS in German-speaking Europe. Little is known about the treatment of large renal stones (LRS > 3 cm) in daily urological practice...
  38. Hindle Fisher I, Pall H, Mitchell R, Kausar J, Cavanna A. Apathy in patients with Parkinson's disease following deep brain stimulation of the subthalamic nucleus. CNS Spectr. 2016;21:258-64 pubmed publisher
    ..All patients were assessed with the Lille Apathy Rating Scale (LARS), the Apathy Scale (AS), and the Parkinson's Disease Questionnaire and were compared to a control group of 38 ..
  39. Mauritz F, Stellato R, van Heurn L, Siersema P, Sloots C, Houwen R, et al. Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. Surg Endosc. 2017;31:3122-3129 pubmed publisher
    ..Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients...
  40. Fang Q, Jiang T, Xu L, Liu H, Mao H, Wang X, et al. A salt-stress-regulator from the Poplar R2R3 MYB family integrates the regulation of lateral root emergence and ABA signaling to mediate salt stress tolerance in Arabidopsis. Plant Physiol Biochem. 2017;114:100-110 pubmed publisher
    ..Wt) under normal conditions; while upon NaCl treatment, the transformants showed improved tolerance, and the LRs emerged faster from salt-induced inhibition...
  41. Jiménez Gómez L, Espin Basany E, Trenti L, Martí Gallostra M, Sanchez Garcia J, Vallribera Valls F, et al. Factors associated with low anterior resection syndrome after surgical treatment of rectal cancer. Colorectal Dis. 2017;: pubmed publisher
    To assess factors independently associated with low anterior resection syndrome (LARS) following resection or rectal cancer.
  42. Shilkofski N, Hunt E. Identification of Barriers to Pediatric Care in Limited-Resource Settings: A Simulation Study. Pediatrics. 2015;136:e1569-75 pubmed publisher
    ..were: (1) to use simulation to identify factors posing barriers to patient care in limited resource settings (LRS); and (2) to understand how simulations in LRS can affect communication and decision-making processes...
  43. Scott H, Dairo A. Maternal Death Surveillance and Response in East and Southern Africa. J Obstet Gynaecol Can. 2015;37:915-21 pubmed
    ..et d’autres partenaires, au moins 15 pays de la région ont intégré le système MDSR dans leurs programmes de soins maternels et néonataux...
  44. Grover M, Mookadam M, Chang Y, Parish J. Validating the Diagnostic Accuracy of the Sleep Apnea Clinical Score for Use in Primary Care Populations. Mayo Clin Proc. 2016;91:469-76 pubmed publisher
    ..Those interpreting tests were blind to the participant's SACS. We determined likelihood ratios (LRs) for OSA diagnosis and posttest probabilities (PTPs)...
  45. de Oliveira C, Oda J, Ariza C, Guembarovski R, Hirata B, de Almeida F, et al. Genetic Polymorphism in the Promoter Region of Serotonin Transporter: Implications for Ethanol Abuse in Children and Adolescents. J Can Acad Child Adolesc Psychiatry. 2016;25:43-9 pubmed
    ..Les variantes additionnelles ont été décrites, bien que leurs influences sur l’utilisation d’éthanol dans l’enfance et l’adolescence ne soient pas définies...
  46. Quesada Martínez M, Fernandez Breis J, Karlsson D. Suggesting Missing Relations in Biomedical Ontologies Based on Lexical Regularities. Stud Health Technol Inform. 2016;228:384-8 pubmed
    ..The analysis of the labels of the classes permits to identify lexical regularities (LRs), which are sets of words that are shared by labels of different classes...
  47. Mauritz F, Rinsma N, van Heurn E, Sloots C, Siersema P, Houwen R, et al. Esophageal mucosal integrity improves after laparoscopic antireflux surgery in children with gastroesophageal reflux disease. Surg Endosc. 2017;31:2910-2917 pubmed publisher
    ..Laparoscopic antireflux surgery (LARS) is a well-established treatment option for children with proton pump inhibitory (PPI) therapy resistant GERD...
  48. Roh E, Song E, Yoon J, Oh S, Chang J, Park H, et al.  Effects of interleukin-4 and interleukin-12B gene polymorphisms on hepatitis B virus vaccination. Ann Hepatol. 2017;16:63-70 pubmed publisher
    ..The percentages of NRs (< 10 mIU/mL), low-titer responders (LRs, 10-100 mIU/mL), and high-titer responders (HRs, ? 100 mIU/mL) were 20.3%, 37.7% and 42.0%, respectively...
  49. Alzahrani S, Al Salamah M, Al Madani W, Elbarbary M. Systematic review and meta-analysis for the use of ultrasound versus radiology in diagnosing of pneumonia. Crit Ultrasound J. 2017;9:6 pubmed publisher
    ..85 (0.84-0.87) and 0.93 (0.92-0.95), respectively. Overall pooled positive and negative LRs were 11.05 (3.76-32.50) and 0.08 (0.04-0.15), pooled diagnostic Odds ratio was 173.64 (38.79-777...
  50. Casey J, McGettigan P, Lynam Lennon N, McDermott M, Regan R, Conroy J, et al. Identification of a mutation in LARS as a novel cause of infantile hepatopathy. Mol Genet Metab. 2012;106:351-8 pubmed publisher
    ..3-q33.1 candidate region that segregated with the hepatopathy. The candidate mutation is located in the LARS gene which encodes a cytoplasmic leucyl-tRNA synthetase enzyme responsible for exclusively attaching leucine to its ..
  51. Engen S, Saether B. r- and K-selection in fluctuating populations is determined by the evolutionary trade-off between two fitness measures: Growth rate and lifetime reproductive success. Evolution. 2017;71:167-173 pubmed publisher
    ..maximizes a function of the deterministic growth rate r0 and the lifetime reproductive success (LRS) R0 , both defined at small densities, as well as the environmental variance...
  52. Boix F, Bolarín J, Eguia J, González Martínez G, De La Pena J, Galián J, et al. Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients. Transplant Proc. 2016;48:2987-2989 pubmed publisher
    ..Pretransplant CD4+CD28+ peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry...
  53. Spiegelman Z, Omer S, Mansfeld B, Wolf S. Function of Cyclophilin1 as a long-distance signal molecule in the phloem of tomato plants. J Exp Bot. 2017;68:953-964 pubmed publisher
    ..exhibiting a pleiotropic phenotype including lack of geotropism, abnormal xylem structure, lack of lateral roots (LRs), and elevated shoot-to-root ratio...
  54. Prasad K, Sehgal I, Agarwal R, Nath Aggarwal A, Behera D, Dhooria S. Assessing the likelihood of obstructive sleep apnea: a comparison of nine screening questionnaires. Sleep Breath. 2017;21:909-917 pubmed publisher
    ..The likelihood ratios (LRs) and other performance characteristics were calculated for the following nine questionnaires: Berlin, modified ..
  55. Szczepanik A, Hulbert A, Lee H, Benedetti C, Snyder L, Byrns J. Effect of HMG CoA reductase inhibitors on the development of chronic lung allograft dysfunction. Clin Transplant. 2017;: pubmed publisher
    ..3% in non-statin group (p=0.012). Statins did not significantly delay the time to development of CLAD in LR but did demonstrate a benefit in patient survival. This article is protected by copyright. All rights reserved...
  56. Chen X, Ma J, Tan M, Yao P, Hu Q, Eriani G, et al. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res. 2011;39:235-47 pubmed publisher
    ..Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein amino acids and then mischarge tRNA(Leu)...
  57. Rutten L, Frei H. Frequently occurring polar symptoms assessed by successful cases. Homeopathy. 2012;101:103-11 pubmed publisher
    ..Some questions were less useful than expected. With an average of 4.8 useful answers per patient and moderate LRs this questionnaire provided substantial information...
  58. Weigl B, Neogi T, McGuire H. Point-of-Care Diagnostics in Low-Resource Settings and Their Impact on Care in the Age of the Noncommunicable and Chronic Disease Epidemic. J Lab Autom. 2014;19:248-57 pubmed publisher
    ..POC diagnostics to strengthen primary care and chronic disease diagnosis and management in a low-resource setting (LRS) to deliver appropriate, consistent, and integrated care...
  59. Schuckit M, Smith T, Gonçalves P, Anthenelli R. Alcohol-related blackouts across 55 weeks of college: Effects of European-American ethnicity, female sex, and low level of response to alcohol. Drug Alcohol Depend. 2016;169:163-170 pubmed publisher
    ..sex and a low LR to alcohol, with the ethnic differences in ARBs most robust in females and drinkers with high LRs. Participation in education programs aimed at heavy drinking was associated with decreases in ARBs...
  60. Hu Y, Ren T, Li Z, Tang Y, Ren Z, Yan B. Molecular mapping and genetic analysis of a QTL controlling spike formation rate and tiller number in wheat. Gene. 2017;634:15-21 pubmed publisher
    ..In the present study, a set of 371 recombinant inbreed line (RIL) population, which were derived from 1BL/LRS wheat-rye translocation lines CN18 and T1208, was analysed by simple sequence repeat (SSR) markers...
  61. Guo T, Chen W, Chen Y, Wu J, Wang Y, Yang J. Diagnostic performance of magnifying endoscopy with narrow-band imaging in differentiating neoplastic colorectal polyps from non-neoplastic colorectal polyps: a meta-analysis. J Gastroenterol. 2018;53:701-711 pubmed publisher
    ..Sensitivity (Sen), specificity (Spe), positive likelihood ratios (+ LRs), negative likelihood ratios (- LRs) and diagnostic odds ratios (DORs) were calculated...
  62. Ye W, Zhang R, Xu X, Liu Y, Ying K. Diagnostic Efficacy and Safety of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Intrathoracic Tuberculosis: A Meta-analysis. J Ultrasound Med. 2015;34:1645-50 pubmed publisher
    ..The pooled sensitivity, specificity, likelihood ratios (LRs), and diagnostic odds ratio were calculated...
  63. Nakamura S, Karalay Ã, Jäger P, Horikawa M, Klein C, Nakamura K, et al. Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat Commun. 2016;7:10944 pubmed publisher
    ..a convergent regulator of autophagy, lysosome biogenesis and longevity, by downregulating TOR signalling via LARS-1/leucyl-transfer RNA synthase. HLH-30 also upregulates MML-1 upon germline removal...
  64. Farge D, Arruda L, Brigant F, Clave E, Douay C, Marjanovic Z, et al. Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients. J Hematol Oncol. 2017;10:21 pubmed publisher
    ..B cells had a positive linear regression slope in group A (LRS = 11.1) and negative in group B (LRS = -11.6)...
  65. Gissi D, Tarsitano A, Leonardi E, Gabusi A, Neri F, Marchetti C, et al. Clonal analysis as a prognostic factor in multiple oral squamous cell carcinoma. Oral Oncol. 2017;67:131-137 pubmed publisher
    ..The purpose was to differentiate secondary tumours into LRs, SPTs and SFTs and evaluate the prognostic impact in terms of survival rate...
  66. Kupsch J, Jackisch T, Matzel K, Zimmer J, Schreiber A, Sims A, et al. Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score. Int J Colorectal Dis. 2018;33:787-798 pubmed publisher
    ..to quantify anorectal dysfunction after treatment for rectal cancer using the low anterior resection syndrome (LARS) score...
  67. Talarico S, Meski A, Buratini L, Manela Azulay M, Simpson H, Sidou F, et al. High Patient Satisfaction of a Hyaluronic Acid Filler Producing Enduring Full-Facial Volume Restoration: An 18-Month Open Multicenter Study. Dermatol Surg. 2015;41:1361-9 pubmed publisher
    ..Performance was assessed by VLS, Lemperle rating scale (LRS), investigator Global Aesthetic Improvement Scale (GAIS), and 3-dimensional (3D) imaging. Most subjects (71...
  68. Brogden G, Shammas H, Maalouf K, Naim S, Wetzel G, Amiri M, et al. Case study on the pathophysiology of Fabry disease: abnormalities of cellular membranes can be reversed by substrate reduction in vitro. Biosci Rep. 2017;37: pubmed publisher
    ..Abnormalities in lipid rafts (LRs) were observed in fibroblasts isolated from a male patient with FD bearing the mutation N215S...
  69. Krupa S, Królikowska A, Reichert P. Postoperative Knee Joint Stability Following Anterior Cruciate Ligament Reconstruction Using the Ligament Advanced Reinforcement System. Polim Med. 2016;46:155-161 pubmed publisher
    ..ligament device made of terephthalic polyethylene polyester fibers, the Ligament Advanced Reinforcement System (LARS)...
  70. Kim C, Jung J, Tung T, Park S. ?-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase. Chem Sci. 2016;7:2753-2761 pubmed publisher
    ..Each library member was subjected to ELISA-based modulator screening for the LRS-RagD interaction, which plays a pivotal role in the nutrient-dependent mTORC1 signalling pathway...
  71. Milotic M, Milotic D, Koprivnikar J. Exposure to a cyanobacterial toxin increases larval amphibian susceptibility to parasitism. Parasitol Res. 2018;117:513-520 pubmed publisher
    ..Here, we examined how exposure to environmentally relevant concentrations of MC-LRs affected the resistance of larval amphibians (northern leopard frog, Rana pipiens) to infection by a helminth ..
  72. Zeng S, Wu X, Lin S, Zeng H, Lu X, Zhang Y, et al. Structural characteristics and physicochemical properties of lotus seed resistant starch prepared by different methods. Food Chem. 2015;186:213-22 pubmed publisher
    Lotus seed resistant starch (LRS) is commonly known as resistant starch type 3 (LRS3)...
  73. Tanaka M, Yase J, Aoki S, Sakurai T, Kanto T, Osakabe M. Physical Control of Spider Mites Using Ultraviolet-B With Light Reflection Sheets in Greenhouse Strawberries. J Econ Entomol. 2016;109:1758-65 pubmed publisher
    ..on how to use UVB irradiation for spider mite control, we tested whether UVB lamp-light reflection sheet (LRS) combinations suppressed the population size of Tetranychus urticae Koch on strawberry in a greenhouse from ..
  74. Cohen J, Ata A, Jackson N, Rahn E, Ramaker R, Cooper S, et al. Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats. Behav Brain Res. 2017;319:110-123 pubmed publisher
    ..defensive burying test elicited greater activation of HR rats' caudal dorsal raphe serotonergic cells compared to LRs, but lead to more pronounced activation throughout LRs' amygdala (lateral, basolateral, central, and basomedial ..
  75. Borstlap W, Musters G, Stassen L, van Westreenen H, Hess D, van Dieren S, et al. Vacuum-assisted early transanal closure of leaking low colorectal anastomoses: the CLEAN study. Surg Endosc. 2018;32:315-327 pubmed publisher
    ..Major LARS was reported in 12/15 (80%) patients. The direct medical costs were €8933 (95% CI 7268-10,707) per patient...
  76. Shadid H, Hossain S. Smoking behaviour, knowledge and perceived susceptibility to lung cancer among secondary-school students in Amman, Jordan. East Mediterr Health J. 2015;21:185-93 pubmed
    ..familial étaient des facteurs importants qui influaient sur le comportement des lycéens en matière de tabagisme et sur leurs perceptions du risque. Ces résultats ont des implications politiques importantes.
  77. Schmidt B, Hupfer M, Saltybaeva N, Kolditz D, Kalender W. Dose Optimization for Computed Tomography Localizer Radiographs for Low-Dose Lung Computed Tomography Examinations. Invest Radiol. 2017;52:81-86 pubmed publisher
    ..Hence, CT localizer radiographs (LRs) might now be considered a significant contributor to the total dose of the CT examination...
  78. Seo J, Choi J, Kim H, Kim J, Yang J, Cuhadar C, et al. Wafer-scale reliable switching memory based on 2-dimensional layered organic-inorganic halide perovskite. Nanoscale. 2017;9:15278-15285 pubmed publisher
    ..Transition from a high resistance state (HRS) to a low resistance state (LRS) occurs at 0...
  79. Le Hir R, Castelain M, Chakraborti D, Moritz T, Dinant S, Bellini C. AtbHLH68 transcription factor contributes to the regulation of ABA homeostasis and drought stress tolerance in Arabidopsis thaliana. Physiol Plant. 2017;160:312-327 pubmed publisher
    ..ACID 8'HYDROXYLASE 3)], in ABA-related response to drought-stress (AtMYC2, AtbHLH122 and AtRD29A) or during LRs development (AtMYC2 and AtABI3) was de-regulated in the overexpressing lines...
  80. Nielson J, Fredrickson E, Waller T, Rendon O, Schubert H, Lin Z, et al. Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. Mol Cell. 2017;68:673-685.e6 pubmed publisher
    ..MTD), which, in unstressed conditions, is inhibited by intramolecular binding to the Vms1 leucine-rich sequence (LRS). Here, we report a 2...
  81. Shiba K, Suzuki N, Shigesada K, Namba Y, Schimmel P, Noda T. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. Proc Natl Acad Sci U S A. 1994;91:7435-9 pubmed
    ..This result may have implications for the historical development of an operational RNA code for amino acids. ..
  82. Buzatti K, Petroianu A. Pathophysiological aspects of the low anterior resection syndrome for treatment of rectal cancer. Rev Col Bras Cir. 2017;44:397-402 pubmed publisher
    ..urgency, multiple evacuations and flatus or stool incontinence characterizing the low anterior resection syndrome - LARS. The purpose of this article is to present a review of the literature on current concepts and pathophysiological ..
  83. Pekkala N, Kotiaho J, Puurtinen M. Laboratory relationships between adult lifetime reproductive success and fitness surrogates in a Drosophila littoralis population. PLoS ONE. 2011;6:e24560 pubmed publisher
    ..Adult lifetime reproductive success (adult LRS) is closely related to the total fitness of individuals, but it is difficult to measure and rarely included in ..
  84. Orman Ligeza B, Parizot B, De Rycke R, Fernandez A, Himschoot E, Van Breusegem F, et al. RBOH-mediated ROS production facilitates lateral root emergence in Arabidopsis. Development. 2016;143:3328-39 pubmed publisher
    ..of RBOH in LRP and/or overlying root tissues decelerates (or accelerates) the development and emergence of LRs. We conclude that RBOH-mediated ROS production facilitates LR outgrowth by promoting cell wall remodeling of ..
  85. Nishiguchi S, Yorozu A, Adachi D, Takahashi M, Aoyama T. Association between mild cognitive impairment and trajectory-based spatial parameters during timed up and go test using a laser range sensor. J Neuroeng Rehabil. 2017;14:78 pubmed publisher
    ..test to investigate the associations between trajectory-based spatial parameters measured by laser range sensor (LRS) and cognitive impairment in community-dwelling older adults...
  86. Rchachi M, El Ouahabi H, Boujraf S, Ajdi F. Primary hyperparathyroidism in pregnancy. Ann Afr Med. 2017;16:145-147 pubmed publisher
    ..Malgré les limites diagnostiques dues à l'interdiction de la scintigraphie au cours de la grossesse, la gestion avait été faite de façon très conservative de sorte à avoir le meilleur pronostic pour les patientes leurs fétus.
  87. Rayevsky A, Sharifi M, Tukalo M. Molecular modeling and molecular dynamics simulation study of archaeal leucyl-tRNA synthetase in complex with different mischarged tRNA in editing conformation. J Mol Graph Model. 2017;76:289-295 pubmed publisher
    ..Some aaRSs accomplish this via editing mechanisms, among which leucyl-tRNA synthetase (LeuRS) edits non-cognate amino acid norvaline mainly by post-transfer editing...
  88. Ribeiro T, Gonçalves B, da Silva M, Novais A, Machado E, Carriço J, et al. Citrobacter portucalensis sp. nov., isolated from an aquatic sample. Int J Syst Evol Microbiol. 2017;67:3513-3517 pubmed publisher
    ..Furthermore, multilocus sequence analysis (MLSA) based on concatenated partial fusA, leuS, pyrG and rpoB sequences confirmed the classification obtained with the recN sequence...
  89. Bugelli G, Dell osso G, Ascione F, Gori E, Bottai V, Giannotti S. LARS™ in ACL reconstruction: evaluation of 60 cases with 5-year minimum follow-up. Musculoskelet Surg. 2018;102:57-62 pubmed publisher
    ..60 patients with minimum follow-up of 5 years who underwent an arthroscopic surgery for ACL reconstruction using LARS™ ligament. Patients with concomitant meniscal or chondral lesions in the same knee were excluded...
  90. Abulaiti A, Yilihamu Y, Yasheng T, Alike Y, Yusufu A. The psychological impact of external fixation using the Ilizarov or Orthofix LRS method to treat tibial osteomyelitis with a bone defect. Injury. 2017;48:2842-2846 pubmed publisher
    ..fixation for a tibial bone defect due to osteomyelitis, and to compare the Orthofix limb reconstruction system (LRS) with the Ilizarov external fixator...
  91. Dana S, Wasmuth J. Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5. Mol Cell Biol. 1982;2:1220-8 pubmed
    ..on that chromosome, were subjected to selective conditions requiring them to retain one of the four linked genes, leuS (encoding leucyl-tRNA synthetase), but lose another, either emtB (encoding ribosomal protein S14) or chr...