Genomes and Genes
Gene Symbol: LARP4
Description: La ribonucleoprotein domain family member 4
Alias: PP13296, la-related protein 4, c-Mpl binding protein
- Houlston R, Cheadle J, Dobbins S, Tenesa A, Jones A, Howarth K, et al. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat Genet. 2010;42:973-7 pubmed publisher..02 × 10??) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10?¹?). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. ..
- Mattijssen S, Maraia R. LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner. Mol Cell Biol. 2016;36:574-84 pubmed publisherb>LARP4 is a protein with unknown function that independently binds to poly(A) RNA, RACK1, and the poly(A)-binding protein (PABPC1). Here, we report on its regulation...
- Seetharaman S, Flemyng E, Shen J, Conte M, Ridley A. The RNA-binding protein LARP4 regulates cancer cell migration and invasion. Cytoskeleton (Hoboken). 2016;73:680-690 pubmed publisherb>LARP4 is a La-related RNA-binding protein implicated in regulating mRNA translation, which interacts with poly(A)-binding protein (PABP)...
- Maraia R, Mattijssen S, Cruz Gallardo I, Conte M. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA. 2017;8: pubmed publisher..One such link may be tRNA surveillance and codon usage by LARP-associated mRNAs. WIREs RNA 2017, 8:e1430. doi: 10.1002/wrna.1430 For further resources related to this article, please visit the WIREs website. ..