Gene Symbol: LARGE2
Description: LARGE xylosyl- and glucuronyltransferase 2
Alias: GYLTL1B, PP5656, LARGE xylosyl- and glucuronyltransferase 2, glycosyltransferase-like 1B, glycosyltransferase-like protein LARGE2, like-glycosyltransferase 2, ortholog of mouse glycosyltransferase-like 1B
Inamori K, Beedle A, de BernabÃ© D, Wright M, Campbell K. LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans. Glycobiology. 2016;26:1284-1296 pubmed
Both LARGE1 (formerly LARGE) and its paralog LARGE2 are bifunctional glycosyltransferases withÂ xylosy- and glucuronyltransferase activities, and are capable of synthesizing polymers composed of a repeating disaccharide [-3XylÎ±1,..
Brockington M, Torelli S, Prandini P, Boito C, Dolatshad N, Longman C, et al
. Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy. Hum Mol Genet. 2005;14:657-65 pubmed
..We have also cloned and overexpressed a homologue of LARGE, glycosyltransferase-like 1B (GYLTL1B). Like LARGE it localized to the Golgi apparatus and stimulated alpha-dystroglycan hyperglycosylation...
Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, et al
. Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci U S A. 2009;106:12109-14 pubmed publisher
..These results identify a previously undescribed role of carbohydrate-dependent cell-BM interaction in tumor suppression and its control by beta3GnT1 and LARGE. ..
Esser A, Miller M, Huang Q, Meier M, Beltran Valero de Bernabe D, Stipp C, et al
. Loss of LARGE2 disrupts functional glycosylation of Î±-dystroglycan in prostate cancer. J Biol Chem. 2013;288:2132-42 pubmed publisher
..Additionally, we demonstrate that LARGE2 (GYLTL1B), a gene not previously implicated in cancer, regulates functional Î±DG glycosylation in prostate cancer cell ..
Inamori K, Willer T, Hara Y, Venzke D, Anderson M, Clarke N, et al
. Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of ?-dystroglycan in cells and tissues. J Biol Chem. 2014;289:28138-48 pubmed publisher
..Both LARGE and its paralog, LARGE2 (also referred to as GYLTL1B) are bifunctional glycosyltransferases with xylosyltransferase (Xyl-T) and glucuronyltransferase (GlcA-T) ..
Miller M, Ma D, Schappet J, Breheny P, Mott S, Bannick N, et al
. Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma. Mol Cancer. 2015;14:141 pubmed publisher
..Most notably, there was a frequent, significant downregulation of GYLTL1B (LARGE2) and ISPD...
Fujimura K, Sawaki H, Sakai T, Hiruma T, Nakanishi N, Sato T, et al
. LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE. Biochem Biophys Res Commun. 2005;329:1162-71 pubmed
..A novel homologous gene to LARGE was identified and named LARGE2. LARGE2 recombinant was co-expressed with alpha-dystroglycan in human embryonic kidney 293T cells to determine its ..
Grewal P, McLaughlan J, Moore C, Browning C, Hewitt J. Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. Glycobiology. 2005;15:912-23 pubmed
..Hence, they are termed dystroglycanopathies. A paralogous gene for LARGE (LARGE2 or GYLTL1B) may also have a role in DG glycosylation...
Huang Q, Miller M, Schappet J, Henry M. The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer. Cancer Biol Ther. 2015;16:125-36 pubmed publisher
..prostate cancer, one mechanism that contributes to Î±DG hypoglycosylation is transcriptional down-regulation of LARGE2 (GYLTY1B), a glycosyltransferase that produces the functional (laminin-binding) glycan on Î±DG, but the ..