LAMTOR5

Summary

Gene Symbol: LAMTOR5
Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Alias: HBXIP, XIP, ragulator complex protein LAMTOR5, HBV X-interacting protein, HBx-interacting protein, hepatitis B virus x interacting protein, hepatitis B virus x-interacting protein (9.6kD), late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
Species: human
Products:     LAMTOR5

Top Publications

  1. Melegari M, Scaglioni P, Wands J. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol. 1998;72:1737-43 pubmed
    ..protein that specifically complexes with the carboxy terminus of wild-type HBx was identified and designated XIP. This 9...
  2. Wang F, Sha L, Ye L, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacol Sin. 2008;29:83-9 pubmed
    We previously found that the hepatitis B X-interacting protein (HBXIP) was able to promote the proliferation of cells...
  3. Liu Q, Bai X, Li H, Zhang Y, Zhao Y, Zhang X, et al. The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells. Int J Cancer. 2013;133:1310-22 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein and plays a key role in the development of breast cancer. However, its mechanisms of action are poorly understood...
  4. Minczuk M, Mroczek S, Pawlak S, Stepien P. Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. FEBS J. 2005;272:5008-19 pubmed
    ..In this report we demonstrate that the hSuv3 protein interacts with HBXIP, previously identified as a cofactor of survivin in suppression of apoptosis and as a protein that binds the HBx ..
  5. Wang F, Sha L, Zhang W, Wu L, Qiao L, Li N, et al. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacol Sin. 2007;28:431-8 pubmed
    To investigate the effect of Hepatitis B X-interacting protein (HBXIP) on cell proliferation. A rabbit antibody against HBXIP was generated. The RNA interference (RNAi) fragment of the HBXIP gene was constructed in the pSilencer-3...
  6. Wen Y, Golubkov V, Strongin A, Jiang W, Reed J. Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation. J Biol Chem. 2008;283:2793-803 pubmed publisher
    ..of hepatitis B virus-encoded oncoprotein HBx, we explored the function of HBx interaction with its cellular target HBXIP. Previously, we demonstrated that viral HBx and cellular HBXIP control mitotic spindle formation, regulating ..
  7. Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, et al. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286:13714-22 pubmed publisher
    ..that miR-520b directly targets the 3'-untranslated region (3'UTR) of either hepatitis B X-interacting protein (HBXIP) or interleukin-8 (IL-8), which has been reported to contribute to cell migration...
  8. Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, et al. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-?B signaling to protect breast cancer cells from complement attack. FEBS Lett. 2012;586:766-71 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is able to enhance migration of breast cancer cells. However, the role of HBXIP in regulation of complement-dependent cytotoxicity (CDC) in breast cancer is not understood...
  9. Liu S, Li L, Zhang Y, Zhang Y, Zhao Y, You X, et al. The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells. J Biol Chem. 2012;287:30228-39 pubmed publisher
    We have reported that hepatitis B X-interacting protein (HBXIP) promotes the proliferation and migration of breast cancer cells. However, the underlying mechanism is poorly understood...

More Information

Publications105 found, 100 shown here

  1. Bar Peled L, Schweitzer L, Zoncu R, Sabatini D. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012;150:1196-208 pubmed publisher
    ..Here, we identify HBXIP and C7orf59 as two additional Ragulator components that are required for mTORC1 activation by amino acids...
  2. Yue L, Li L, Liu F, Hu N, Zhang W, Bai X, et al. The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis. 2013;34:927-35 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is an important oncoprotein that plays critical role in the development of cancer...
  3. Zhang Y, Zhao Y, Li H, Li Y, Cai X, Shen Y, et al. The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells. J Biol Chem. 2013;288:18961-74 pubmed publisher
    ..We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) acts as a novel transcriptional coactivator to promote proliferation and migration of breast cancer cells...
  4. Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 2003;22:2729-40 pubmed
    ..We show that survivin forms complexes with a cellular protein, hepatitis B X-interacting protein (HBXIP), which was originally recognized for its association with the X protein of hepatitis B virus (HBX)...
  5. Liu M, Wu X, Huo W, Li J, Weng X, Liu J, et al. Differential inhibition of GH family 11 endo-xylanase by rice xylanase inhibitor and verification by a modified yeast two-hybrid system. Int J Biol Macromol. 2019;132:514-523 pubmed publisher
    Rice xylanase inhibitor (RIXI) is a XIP-type xylanase inhibitor protein that protects rice cells from pathogenic organisms. RIXI inhibits most microbial xylanases and thus decreases their practical application...
  6. Zhou X, Wang X, Duan J, Sun W, Chen Z, Li Q, et al. HBXIP protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas. Pathol Res Pract. 2019;215:343-346 pubmed publisher
    Hepatitis B virus X-interacting protein (HBXIP) is associated with a variety of tumors...
  7. Zhou X, Zhu C, Wu Z, Guo X, Zou W. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. Oncogene. 2019;: pubmed publisher
    ..Mammalian hepatitis B X-interacting protein (HBXIP) has critical roles in modulating cancer malignance and tumor progression...
  8. Gladitz J, Klink B, Seifert M. Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion. Acta Neuropathol Commun. 2018;6:49 pubmed publisher
    ..g. ELTD1, SDHB, SEPW1, SLC17A7, SZRD1, THAP3, ZBTB17) are likely to push, whereas others (e.g. CAP1, HBXIP, KLK6, PARK7, PTAFR) might counteract oligodendroglioma development...
  9. Kwon H, Koo J, Zufall F, Leinders Zufall T, Margolis F. Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009;4:e4260 pubmed publisher
    ..We demonstrate the direct interaction of the XIP regulatory-peptide of NCX with calmodulin (CaM)...
  10. Underhill S, Shields R, Kaspar J, Haider M, Burne R, Hagen S. Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence. mSphere. 2018;3: pubmed publisher
    ..ComS is the precursor of XIP, a seven-residue peptide that is imported into the cell and interacts with the cytosolic receptor ComR to form a ..
  11. Deng L, Gan X, Ito M, Chen M, Aly H, Matsui C, et al. Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA. J Virol. 2019;93: pubmed publisher
    ..These results suggest that Prdx1 negatively regulates HBV propagation. Our findings may shed new light on the roles of Prdx1 and Exosc5 in host defense mechanisms in HBV infection. ..
  12. Junges R, Khan R, Tovpeko Y, Ã…mdal H, Petersen F, Morrison D. Markerless Genome Editing in Competent Streptococci. Methods Mol Biol. 2017;1537:233-247 pubmed
    ..mutans with sigX-inducing peptide pheromone (XIP) in a chemically defined medium (CDM) or of S...
  13. Liu B, Wang T, Li L, Zhang L, Liu Y, Feng J, et al. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer. Acta Pharmacol Sin. 2019;40:530-538 pubmed publisher
    We have reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can act as an oncogenic transcriptional co-activator to modulate gene expression, promoting breast cancer development...
  14. Mashburn Warren L, Goodman S, Federle M, Prehna G. The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus. Sci Rep. 2018;8:16535 pubmed publisher
    ..The ComR-XIP (mature ComS peptide) complex induces expression of the alternative sigma factor SigX, which targets RNA polymerase ..
  15. Son M, Shields R, Ahn S, Burne R, Hagen S. Bidirectional signaling in the competence regulatory pathway of Streptococcus mutans. FEMS Microbiol Lett. 2015;362: pubmed publisher
    ..encodes a sigma factor that is required for development of genetic competence, in response to the peptide signals XIP and CSP and environmental factors...
  16. Chang H, Yendrek C, Caetano Anolles G, Hartman G. Genomic characterization of plant cell wall degrading enzymes and in silico analysis of xylanses and polygalacturonases of Fusarium virguliforme. BMC Microbiol. 2016;16:147 pubmed publisher
    ..virguliforme, FvXyn11A and FvXyn11B, have conserved residues that allow xylanase inhibitor protein I (XIP-I) binding...
  17. Venkatesh J, Yu J, Gaston D, Park S. Molecular evolution and functional divergence of X-intrinsic protein genes in plants. Mol Genet Genomics. 2015;290:443-60 pubmed publisher
    X-intrinsic proteins (XIPs) are a novel class of major intrinsic proteins found in diverse organisms. Recently, XIP genes have been reported to be involved in the transport of a wide range of hydrophobic solutes; however, the ..
  18. Radic C, Rossetti L, Abelleyro M, Tetzlaff T, Candela M, Neme D, et al. Phenotype-genotype correlations in hemophilia A carriers are consistent with the binary role of the phase between F8 and X-chromosome inactivation. J Thromb Haemost. 2015;13:530-9 pubmed publisher
    ..gene [AR] system) in blood leukocyte DNA was performed in carriers, by comparison of a model correlating C and XIP with arbitrary models devoid of biological significance, and with C levels in non-carriers (mean model) as a proxy ..
  19. Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, et al. Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells. J Biol Chem. 2018;293:2053-2065 pubmed publisher
    ..We recently reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can modulate glucose metabolism reprogramming in cancer cells...
  20. Li H, Wang Z, Jiang M, Fang R, Shi H, Shen Y, et al. The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways. Acta Pharmacol Sin. 2018;39:1787-1796 pubmed publisher
    Mammalian hepatitis B X-interacting protein (HBXIP) is an 18-kDa protein that regulates a large number of transcription factors such as TF-IID, E2F1, SP1, STAT3, c-Myc, and LXR by serving as an oncogenic transcription coactivator and ..
  21. Chu S, Zhang Z, Zhang W, Zhang M, Gao Y, Han N, et al. Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion. Mol Neurobiol. 2017;54:524-540 pubmed publisher
    ..Additionally, IMM-H004 also enhanced the expression of hepatitis B X-interacting protein (HBXIP), which formed a complex with survivin to prevent the activation of caspase death cascade, thereby halting ..
  22. Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, et al. The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Lett. 2014;355:288-96 pubmed publisher
    We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) plays a crucial role in the promotion of migration of breast cancer cells...
  23. Li D, Ding J, Chen Z, Chen Y, Lin N, Chen F, et al. Accurately mapping the location of the binding site for the interaction between hepatitis B virus X protein and cytochrome c oxidase III. Int J Mol Med. 2015;35:319-24 pubmed publisher
    ..To the best of our knowledge, this is the first study showing to demonstrate that aa72-117 in HBx is the key region for binding with COXIII. ..
  24. Son M, Ghoreishi D, Ahn S, Burne R, Hagen S. Sharply Tuned pH Response of Genetic Competence Regulation in Streptococcus mutans: a Microfluidic Study of the Environmental Sensitivity of comX. Appl Environ Microbiol. 2015;81:5622-31 pubmed publisher
    ..pH and the concentrations of two secreted peptides, designated CSP (competence-stimulating peptide) and XIP (comX-inducing peptide)...
  25. Han Y, Ryu S, Park S, Lee K, Lee S, Ho W. Ca(2+) clearance by plasmalemmal NCLX, Li(+)-permeable Na(+)/Ca(2+) exchanger, is required for the sustained exocytosis in rat insulinoma INS-1 cells. Pflugers Arch. 2015;467:2461-72 pubmed publisher
    ..b>XIP (NCX inhibitory peptide) or Na(+) replacement for inhibiting Na(+)-dependent Ca(2+) clearance also selectively ..
  26. Hayashi M, Deng L, Chen M, Gan X, Shinozaki K, Shoji I, et al. Interaction of the hepatitis B virus X protein with the lysine methyltransferase SET and MYND domain-containing 3 induces activator protein 1 activation. Microbiol Immunol. 2016;60:17-25 pubmed publisher
    ..In conclusion, a novel HBx-interacting protein, SMYD3, was identified, leading to proposal of a novel mechanism of AP-1 activation in HBV-infected cells. ..
  27. Talagas A, Fontaine L, Ledesma García L, Mignolet J, Li de la Sierra Gallay I, Lazar N, et al. Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS. PLoS Pathog. 2016;12:e1005980 pubmed publisher
    ..ComR is directly activated by the binding of its associated pheromone XIP, the mature form of the comX/sigX-inducing-peptide ComS...
  28. Lopez D, Amira M, Brown D, Muries B, Brunel Michac N, Bourgerie S, et al. The Hevea brasiliensis XIP aquaporin subfamily: genomic, structural and functional characterizations with relevance to intensive latex harvesting. Plant Mol Biol. 2016;91:375-96 pubmed publisher
    X-Intrinsic Proteins (XIP) were recently identified in a narrow range of plants as a full clade within the aquaporins. These channels reportedly facilitate the transport of a wide range of hydrophobic solutes...
  29. Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, et al. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016;382:147-156 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) as an oncoprotein plays crucial roles in the development of cancer, involving glucose metabolism reprogramming...
  30. Tundo S, Moscetti I, Faoro F, Lafond M, Giardina T, Favaron F, et al. Fusarium graminearum produces different xylanases causing host cell death that is prevented by the xylanase inhibitors XIP-I and TAXI-III in wheat. Plant Sci. 2015;240:161-9 pubmed publisher
    ..Subsequently, we demonstrated that TAXI-III and XIP-I prevented both the enzyme and host cell death activities of F. graminearum xylanases...
  31. Zhan Y, Sun X, Rong G, Hou C, Huang Y, Jiang D, et al. Identification of two transcription factors activating the expression of OsXIP in rice defence response. BMC Biotechnol. 2017;17:26 pubmed publisher
    Xylanase inhibitors have been confirmed to be involved in plant defence. OsXIP is a XIP-type rice xylanase inhibitor, yet its transcriptional regulation remains unknown...
  32. Kong W, Bendahmane M, Fu X. Genome-Wide Identification and Characterization of Aquaporins and Their Role in the Flower Opening Processes in Carnation (Dianthus caryophyllus). Molecules. 2018;23: pubmed publisher
    ..Thirty DcaAQPs were identified and grouped to five subfamilies: nine PIPs, 11 TIPs, six NIPs, three SIPs, and one XIP. Subsequently, gene structure, protein motifs, and co-expression network of DcaAQPs were analyzed and substrate ..
  33. Li Y, Wang Z, Shi H, Li H, Li L, Fang R, et al. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc. Cancer Res. 2016;76:293-304 pubmed publisher
    ..genes in human MCF-7 breast cancer cells, we found that their promoters could be occupied by the oncoprotein HBXIP. We confirmed that the HBXIP expression correlated with expression of the c-Myc target genes cyclin A, eIF4E, and ..
  34. Huang X, Palmer S, Ahn S, Richards V, Williams M, Nascimento M, et al. A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans. Appl Environ Microbiol. 2016;82:2187-201 pubmed publisher
    ..mutans. A12, but not S. gordonii, could also block the XIP (comX-inducing peptide) signaling pathway, which is the proximal regulator of genetic competence in S...
  35. Ishibashi K, Morishita Y, Tanaka Y. The Evolutionary Aspects of Aquaporin Family. Adv Exp Med Biol. 2017;969:35-50 pubmed publisher
    ..the plant lineage has lost AQGP after algal ancestors with extensive diversifications of CAQPs into PIP, TIP, SIP, XIP, HIP and LIP with a possible horizontal transfer of NIP from bacteria...
  36. Shanker E, Morrison D, Talagas A, Nessler S, Federle M, Prehna G. Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species. PLoS Pathog. 2016;12:e1005979 pubmed publisher
    ..One such system, ComRS, consists of a peptide (ComS) that is processed (XIP), secreted, and later imported into the cytoplasm, where it binds and activates the transcription factor ComR...
  37. Salvadori G, Junges R, Khan R, Ã…mdal H, Morrison D, Petersen F. Natural Transformation of Oral Streptococci by Use of Synthetic Pheromones. Methods Mol Biol. 2017;1537:219-232 pubmed
    ..found in Streptococcus mutans (also named CSP, although different from the former) and the SigX-inducing peptides (XIP), in the mutans, salivarius, bovis, and pyogenes groups of streptococci...
  38. Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, et al. The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. Cancer Lett. 2014;352:169-78 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is an important oncoprotein in hepatocarcinogenesis...
  39. Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, et al. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene. 2016;35:4048-57 pubmed publisher
    ..In this study, we explored the hypothesis that the oncoprotein hepatitis B X-interacting protein (HBXIP) is involved in the reduction of MST1 in breast cancer...
  40. Szafranski S, Deng Z, Tomasch J, Jarek M, Bhuju S, Rohde M, et al. Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome. BMC Genomics. 2017;18:238 pubmed publisher
    ..The gene for the synthesis of the QS signal XIP is essential for this interaction. Transcriptome sequencing of biofilms revealed that S...
  41. Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, et al. Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. J Hematol Oncol. 2018;11:26 pubmed publisher
    ..Here, we were interested in the potential effect of HBXIP, an oncoprotein involved in the acceleration of cancer progression, on the modulation of HOXB13 in TAM resistance ..
  42. Zhang Y, Zhao Y, Li L, Shen Y, Cai X, Zhang X, et al. The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast cancer cells. Biochem Biophys Res Commun. 2013;434:305-10 pubmed publisher
    We have reported that the oncoprotein hepatitis B virus X-interacting protein (HBXIP) acts as a novel transcriptional coactivator to promote proliferation and migration of breast cancer cells...
  43. Moye Z, Son M, Rosa Alberty A, Zeng L, Ahn S, Hagen S, et al. Effects of Carbohydrate Source on Genetic Competence in Streptococcus mutans. Appl Environ Microbiol. 2016;82:4821-4834 pubmed publisher
    ..of the population activating expression of comX and comS, encoding the precursor of comX-inducing peptide (XIP), after addition of CSP, than growth in glucose...
  44. Kong H, Park M, Hong S, Yu H, Lee Y, Choi Y, et al. Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. Hepatology. 2003;38:1258-66 pubmed
    ..In conclusion, these results show that HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. ..
  45. Reck M, Tomasch J, Wagner Dobler I. The Alternative Sigma Factor SigX Controls Bacteriocin Synthesis and Competence, the Two Quorum Sensing Regulated Traits in Streptococcus mutans. PLoS Genet. 2015;11:e1005353 pubmed publisher
    Two small quorum sensing (QS) peptides regulate competence in S. mutans in a cell density dependent manner: XIP (sigX inducing peptide) and CSP (competence stimulating peptide). Depending on the environmental conditions isogenic S...
  46. Makowski M, Willems E, Jansen P, Vermeulen M. Cross-linking immunoprecipitation-MS (xIP-MS): Topological Analysis of Chromatin-associated Protein Complexes Using Single Affinity Purification. Mol Cell Proteomics. 2016;15:854-65 pubmed publisher
    ..Here, we present cross-linking immunoprecipitation-MS (xIP-MS), a simple, rapid, and efficient method for structurally probing chromatin-associated protein complexes using ..
  47. Zaccaria E, Wells J, van Baarlen P. Metabolic Context of the Competence-Induced Checkpoint for Cell Replication in Streptococcus suis. PLoS ONE. 2016;11:e0153571 pubmed publisher
    ..We investigated the global response of Streptococcus suis to exposure to the SigX competence-inducing peptide (XIP), and thus to the activation of the competence machinery, using time series analysis together with PCA analysis, ..
  48. Arzumanyan A, Friedman T, Kotei E, Ng I, Lian Z, Feitelson M. Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer. Oncogene. 2012;31:563-72 pubmed publisher
    ..Thus, histone deacetylation of CDH1 and downregulation of miR-373, together with the previously demonstrated hypermethylation of CDH1 by HBx, may be important for the understanding of HBV-related carcinogenesis...
  49. Fan W, Cheng J, Zhang S, Liu X. Cloning and functions of the HBxAg-binding protein XBP1. Mol Med Rep. 2013;7:618-22 pubmed publisher
  50. Lee A, Ren J, Wong E, Ban K, Lee L, Lee C. The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage. J Biol Chem. 2005;280:33525-35 pubmed
    ..In hepatitis B virus-infected hepatocytes, a chronic infection may present the opportunity for such a DNA-damaging event to occur, and accumulated errors caused by the inhibition of DNA repair by HBx may result in oncogenesis. ..
  51. Krepela E, Dankova P, Moravcikova E, Krepelova A, Prochazka J, Cermak J, et al. Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma. Int J Oncol. 2009;35:1449-62 pubmed
    ..study, we investigated the expression status of survivin and its interactants hepatitis B X-interacting protein (HBXIP) and XIAP in non-small cell lung carcinoma (NSCLC) cell lines and NSCLC tumours and matched lungs from surgically ..
  52. Kaspar J, Underhill S, Shields R, Reyes A, Rosenzweig S, Hagen S, et al. Intercellular Communication via the comX-Inducing Peptide (XIP) of Streptococcus mutans. J Bacteriol. 2017;199: pubmed publisher
    ..of natural genetic competence by ComR and the com X -inducing peptide (XIP) in Streptococcus mutans Although the competence pathway can be activated by the addition of synthetic XIP ..
  53. Zhang T, Wang R, Wang Z, Wang X, Wang F, Ding J. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun. 2017;8:1394 pubmed publisher
    ..mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive...
  54. Zhou X, Guo X, Song Y, Zhu C, Zou W. The LPI/GPR55 axis enhances human breast cancer cell migration via HBXIP and p-MLC signaling. Acta Pharmacol Sin. 2018;39:459-471 pubmed publisher
    ..Furthermore, dual-luciferase report gene assays showed that GPR55 upregulated HBXIP at the promoter; GPR55 expression levels were positively correlated with HBXIP expression levels in breast cancer ..
  55. Germain M, Chatel Chaix L, Gagné B, Bonneil E, Thibault P, Pradezynski F, et al. Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Mol Cell Proteomics. 2014;13:184-203 pubmed publisher
    ..The study revealed highly stringent association between HCV interactors and their functional contribution to the viral replication cycle and pathogenesis. ..
  56. Shamay M, Barak O, Doitsh G, Ben Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem. 2002;277:9982-8 pubmed
    ..Collectively our data suggest that pX recruits and potentiates a novel putative transcription coactivator to regulate NF-kappaB. The implication of pX-HBXAP interaction in the development of hepatocellular carcinoma is discussed. ..
  57. Wang F, Fei H, Qi B, Yao S, Chang Z. Overexpression of hepatitis B x-interacting protein in HepG2 cells enhances tumor-induced angiogenesis. Mol Cell Biochem. 2012;364:165-71 pubmed publisher
    ..Hepatitis B x-interacting protein (HBXIP), a cofactor of survivin, was originally identified by binding with the C-terminus of the HBx and negatively ..
  58. Wang S, Tsun Z, Wolfson R, Shen K, Wyant G, Plovanich M, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015;347:188-94 pubmed publisher
    ..Thus, SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway. ..
  59. Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, et al. The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. J Biol Chem. 2015;290:22649-61 pubmed publisher
    ..We had reported previously that the oncoprotein hepatitis B X-interacting protein (HBXIP) is a key oncoprotein in the development of cancer. Thus, we supposed that HBXIP might be involved in the event...
  60. Peng L, Zhang R, Zhao J, Min J, Pu C, Zhou H, et al. [The different structure forms of HBx protein influence their intracellular distribution in hepatocellular carcinoma HepG2 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:611-4 pubmed
    ..We have provided significant experimental evidences for research of the role of HBX protein in the development of hepatocellular carcinoma, and especially the references for explanation of the outcomes in vitro transfection experiments. ..
  61. Xu F, You X, Liu F, Shen X, Yao Y, Ye L, et al. The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer Lett. 2013;333:124-32 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein...
  62. Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, et al. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis. 2014;35:1144-53 pubmed publisher
    ..Previously, we reported that hepatitis B X-interacting protein (HBXIP) functioned as an oncoprotein in breast cancer...
  63. Rebsamen M, Pochini L, Stasyk T, de Araújo M, Galluccio M, Kandasamy R, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015;519:477-81 pubmed publisher
    ..Thus SLC38A9 is a physical and functional component of the amino acid sensing machinery that controls the activation of mTOR. ..
  64. Li L, Liu B, Zhang X, Ye L. The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation. Biochem Biophys Res Commun. 2015;458:720-725 pubmed publisher
    We have documented that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells...
  65. Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, et al. The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Biochem Biophys Res Commun. 2016;471:89-94 pubmed publisher
    We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells...
  66. van de Klundert M, van den Biggelaar M, Kootstra N, Zaaijer H. Hepatitis B Virus Protein X Induces Degradation of Talin-1. Viruses. 2016;8: pubmed
    ..To identify such host proteins, we systematically analyzed the HBx interactome. One HBx interacting protein, talin-1 (TLN1), was proteasomally degraded upon HBx expression...
  67. Chang J, Federle M. PptAB Exports Rgg Quorum-Sensing Peptides in Streptococcus. PLoS ONE. 2016;11:e0168461 pubmed publisher
    ..mutans endogenous pheromone XIP (sigX inducing peptide) was only partially disrupted, indicating that a secondary secretion pathway for XIP exists.
  68. Bhattacharjee B, Pathaw N, Chrungoo N, Bhattacharjee A. Molecular modelling, dynamics simulation and characterization of antifungal chitinase from Sechium edule. Gene. 2017;606:39-46 pubmed publisher
    ..Likewise, a part of the conserved domain area fits in with xylanase inhibitor Xip-1 and the class ??? plant chitinases, for example, concanavalin B, hevamine, which have a GH18 area...
  69. Khan R, Junges R, Åmdal H, Chen T, Morrison D, Petersen F. A positive feedback loop mediated by Sigma X enhances expression of the streptococcal regulator ComR. Sci Rep. 2017;7:5984 pubmed publisher
    ..mutans, Streptococcus suis, and species of the bovis, salivarius and pyogenic groups of streptococci, the pheromone XIP is sensed by the intra-cellular regulator ComR, that in turn activates the transcription of comS, encoding the XIP ..
  70. Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, et al. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett. 2018;415:11-19 pubmed publisher
    ..Aberrant expression of Mammalian hepatitis B X-interacting protein (HBXIP) drives the aggressiveness of breast cancer...
  71. Cheng S, Ren J, Cai X, Jiang H, Chen J. HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. Biochem Biophys Res Commun. 2018;496:904-910 pubmed publisher
    ..First, SIRT2 could promote HBV replication. And then HBx-elevated SIRT2 could enhance the transformation of HBV-mediated HCC. Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC by interaction with HBx. ..
  72. Hove Madsen L, Llach A, Tort L. Na(+)/Ca(2+)-exchange activity regulates contraction and SR Ca(2+) content in rainbow trout atrial myocytes. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1856-64 pubmed
    ..5 +/- 0.2 to 1.0 +/- 0.2 and 0.5 +/- 0.06 amol/pF. With 20 microM exchanger inhibitory peptide (XIP) in the patch pipette Ca(2+) extrusion 20 min after patch break was 39 +/- 8% of its initial value...
  73. Lee S, Park S, Lim S, Jung G. The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes. Biochim Biophys Acta. 2005;1741:75-84 pubmed
    ..We conclude that HBx up-regulates LTalpha expression at the transcriptional level through an NF-kappaB-dependent mechanism and, therefore, the up-regulated LTalpha may be secreted and involved in the HBx-induced NF-kappaB activation. ..
  74. Xu F, Zhu X, Han T, You X, Liu F, Ye L, et al. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1. Int J Oncol. 2014;45:255-63 pubmed publisher
    Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. We have previously reported that HBXIP promotes the proliferation and migration of breast cancer cells...
  75. Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, et al. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Lett. 2017;385:234-242 pubmed publisher
    ..Here, we supposed that the oncoprotein hepatitis B X-interacting protein (HBXIP) might be involved in the modulation of YAP in liver cancer...
  76. Li X, Liu S. Suppression of HBXIP Reduces Cell Proliferation, Migration and Invasion In Vitro, and Tumorigenesis In Vivo in Human Urothelial Carcinoma of the Bladder. Cancer Biother Radiopharm. 2016;31:311-316 pubmed
    Hepatitis B X-interacting protein (HBXIP) has been found overexpressed in several types of human cancer, however, the status of HBXIP expression in urothelial carcinoma of the bladder (UCB) has not been explored...
  77. Zou W, Ma X, Yang H, Hua W, Chen B, Cai G. Hepatitis B X-interacting protein promotes cisplatin resistance and regulates CD147 via Sp1 in ovarian cancer. Exp Biol Med (Maywood). 2017;242:497-504 pubmed publisher
    ..Impact statement We found that hepatitis B X-interacting protein (HBXIP) was able to activate the CD147 promoter through Sp1...
  78. Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, et al. Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J Hepatol. 2006;45:805-12 pubmed
    ..001, odds ratio: 4.89). The codon-38 change in genotype C is an independent risk factor for the development of HCC and may serve as a useful molecular marker for predicting the clinical outcomes in patients infected with HBV. ..
  79. Jin J, Tang S, Xia L, Du R, Xie H, Song J, et al. MicroRNA-501 promotes HBV replication by targeting HBXIP. Biochem Biophys Res Commun. 2013;430:1228-33 pubmed publisher
    ..2.15 cells. Luciferase reporter and western blot assays revealed that HBXIP, an inhibitor of HBV replication, was a potential target of miR-501...
  80. Cheng D, Liang B, Li Y. HBXIP expression predicts patient prognosis in breast cancer. Med Oncol. 2014;31:210 pubmed publisher
    Emerging evidence demonstrated that hepatitis B virus X-interacting protein (HBXIP) has broad roles in cancers...
  81. Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, et al. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2017;484:565-571 pubmed publisher
    The oncoprotein hepatitis B X-interacting protein (HBXIP) results in the dysregulation of lipid metabolism to enhance the development of breast cancer...
  82. Wang Y, Li N, Che S, Jin T, Piao J, Liu S, et al. HBXIP suppression reduces cell proliferation and migration and its overexpression predicts poor prognosis in non-small-cell lung cancer. Tumour Biol. 2017;39:1010428317709675 pubmed publisher
    Emerging evidence has demonstrated that the high expression of HBXIP has been correlated with many cancers...
  83. Li Y, Lu Y. Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells. World J Gastroenterol. 2002;8:213-6 pubmed
    ..nexin 1 (GDN/PN1) gene expression level and 4-fold increase of hepatitis B virus x-interacting protein (XIP) mRNA level in BGC823 cells after Allitridi treatment for 72h...
  84. Chen J, Siddiqui A. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007;81:6757-60 pubmed
    ..These studies provide an insight into the mechanisms by which HBV induces intracellular events relevant to liver disease pathogenesis, including HCC. ..
  85. Oyagbemi A, Azeez O, Saba A. Hepatocellular carcinoma and the underlying mechanisms. Afr Health Sci. 2010;10:93-8 pubmed
    ..Mutant HBx proteins still retain their ability to bind to p53 thereby attenuating DNA repair and p53-mediated apoptosis. ..
  86. Zhang W, Lu Z, Kong G, Gao Y, Wang T, Wang Q, et al. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Mol Cancer. 2014;13:128 pubmed publisher
    ..The oncopreotein hepatitis B X-interacting protein (HBXIP), a target of miR-520b, is involved in the development of cancer...
  87. Rivière L, Gerossier L, Ducroux A, Dion S, Deng Q, Michel M, et al. HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase. J Hepatol. 2015;63:1093-102 pubmed publisher
    ..HBx is able to relieve this repression and allow the establishment of active chromatin. ..
  88. Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, et al. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade. Cancer Res. 2016;76:4696-707 pubmed publisher
    ..Here, we report that the oncoprotein, hepatitis B X-interacting protein (HBXIP, LAMTOR5) contributes to abnormal lipid metabolism...
  89. Li N, Wang Y, Che S, Yang Y, Piao J, Liu S, et al. HBXIP over expression as an independent biomarker for cervical cancer. Exp Mol Pathol. 2017;102:133-137 pubmed publisher
    Emerging evidence demonstrated that hepatitis B virus X-interacting protein (HBXIP) has broad roles in cancers...
  90. Bertocci B, Lecoeuche D, Sterlin D, Kühn J, Gaillard B, De Smet A, et al. Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation. J Immunol. 2017;199:2408-2420 pubmed publisher
    ..show, in the BL2 Burkitt's lymphoma cell line, that KLHL6 interacts with Cullin3, but also that it binds to HBXIP/Lamtor5, a protein involved in cell-cycle regulation and cytokinesis...
  91. Fei H, Li Z, Ying Zhang -, Yue Liu -, Wang F. HBXIP regulates etoposide-induced cell cycle checkpoints and apoptosis in MCF-7 human breast carcinoma cells. Gene. 2018;647:39-47 pubmed publisher
    ..In this study, we investigate the effects of HBXIP gene silencing on etoposide chemosensitivity in MCF-7 human breast cancer cells...
  92. Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, et al. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015;6:27199-213 pubmed publisher
    The glucose metabolism reprogramming is a hallmark of cancer. The oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development of breast cancer...